CA2724008A1 - Fused pyrimidine derivatives as trpv3 modulators - Google Patents
Fused pyrimidine derivatives as trpv3 modulators Download PDFInfo
- Publication number
- CA2724008A1 CA2724008A1 CA2724008A CA2724008A CA2724008A1 CA 2724008 A1 CA2724008 A1 CA 2724008A1 CA 2724008 A CA2724008 A CA 2724008A CA 2724008 A CA2724008 A CA 2724008A CA 2724008 A1 CA2724008 A1 CA 2724008A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- unsubstituted
- compound
- pyrido
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 230000008569 process Effects 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims description 246
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- -1 3-Methoxy-2-propoxyphenyl Chemical group 0.000 claims description 65
- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 125000003118 aryl group Chemical group 0.000 claims description 55
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 49
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 36
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| US61/048,276 | 2008-04-28 | ||
| PCT/IN2009/000025 WO2009109987A2 (en) | 2008-01-11 | 2009-01-07 | Fused pyrimidine derivatives as trpv3 modulators |
Publications (1)
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| CA2724008A1 true CA2724008A1 (en) | 2009-09-11 |
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| CA2724008A Abandoned CA2724008A1 (en) | 2008-01-11 | 2009-01-07 | Fused pyrimidine derivatives as trpv3 modulators |
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| US8119647B2 (en) * | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
| WO2010073128A2 (en) | 2008-12-26 | 2010-07-01 | Glenmark Pharmaceuticals, S.A. | Fused imidazole derivatives as trpv3 antagonist |
| MY168958A (en) * | 2012-04-23 | 2019-01-28 | Genentech Inc | Intermediates and processes for preparing compounds |
| JP7638987B2 (ja) | 2019-11-25 | 2025-03-04 | アムジエン・インコーポレーテツド | デルタ－５デサチュラーゼ阻害剤としての複素環式化合物、及び使用法 |
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| US3907798A (en) * | 1966-06-15 | 1975-09-23 | Sterling Drug Inc | Preparation of 4H-pyrido{8 1,2-a{9 pyrimidin-4-ones from cyclic alkylidene 2-pyridylaminomethylenemalonates |
| HU168014B (enExample) * | 1973-03-30 | 1976-02-28 | ||
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| US4223031A (en) * | 1978-05-05 | 1980-09-16 | Mead Johnson & Company | Azolopyrimidinones |
| IL59802A (en) * | 1979-05-08 | 1983-07-31 | Erba Farmitalia | Substituted pyrido(1,2-a)pyrimidine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
| AU551718B2 (en) * | 1981-07-15 | 1986-05-08 | Farmitalia Carlo Erba S.P.A. | Substituted thiazolo(3,2-alpha)pyrimidines |
| US4537962A (en) * | 1982-02-04 | 1985-08-27 | Farmitalia Carlo Erba, S.P.A. | Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions containing them |
| GB8300728D0 (en) * | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
| US5204352A (en) * | 1987-09-29 | 1993-04-20 | The United States Of America As Represented By The Secretary Of The Army | Compounds exhibiting anti-parasitic activity and a method for their use |
| US5252572A (en) * | 1988-02-03 | 1993-10-12 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. | Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same |
| IT1263804B (it) * | 1993-01-22 | 1996-09-03 | Luso Farmaco Inst | Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista |
| AU1823895A (en) * | 1994-02-23 | 1995-09-11 | Kyowa Hakko Kogyo Co. Ltd. | Xanthine derivative |
| JPH07242666A (ja) | 1994-03-08 | 1995-09-19 | Fujisawa Pharmaceut Co Ltd | 複素環化合物 |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| KR100446363B1 (ko) * | 1997-11-11 | 2004-09-01 | 화이자 프로덕츠 인코포레이티드 | 항암제로 유용한 티에노피리미딘 및 티에노피리딘 유도체 |
| US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| KR20030083755A (ko) * | 2001-03-26 | 2003-10-30 | 노파르티스 아게 | 동통 치료를 위한 바닐로이드 수용체 길항제로서의 용도를위한 융합 피리딘 유도체 |
| WO2005049613A1 (en) * | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| JP2008503562A (ja) * | 2004-06-23 | 2008-02-07 | イデニクス（ケイマン）リミテツド | フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体 |
| ATE369806T1 (de) * | 2004-08-18 | 2007-09-15 | Robert Boettcher | Einschraubbares enossales dentalimplantat |
| ZA200702380B (en) * | 2004-09-03 | 2008-09-25 | Celgene Corp | Substituted heterocyclic compounds and uses thereof |
| US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| MX2007007103A (es) | 2004-12-13 | 2008-03-10 | Lilly Co Eli | Derivados espiro como inhibidores de lipoxigenasa. |
| US20080220968A1 (en) * | 2005-07-05 | 2008-09-11 | Ge Healthcare Bio-Sciences Ab | [1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg |
| AP2008004432A0 (en) * | 2005-10-07 | 2008-04-30 | Glenmark Pharmaceuticals Sa | Substituted benzofused derivatives and their use as vanilloid receptor ligands |
| AU2006311883A1 (en) * | 2005-11-04 | 2007-05-18 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| GB0525069D0 (en) * | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| TW201900217A (zh) * | 2005-12-22 | 2019-01-01 | 美商海卓勒生物科學公司 | 用於調節ｔｒｐａ１功能之化合物 |
| US8980954B2 (en) * | 2006-04-25 | 2015-03-17 | Stc.Unm | Substituted cis- and trans-stilbenes as therapeutic agents |
| JP2009542608A (ja) | 2006-06-29 | 2009-12-03 | アステックス・セラピューティクス・リミテッド | 医薬組合せ剤 |
| EP2049548A1 (en) * | 2006-07-27 | 2009-04-22 | UCB Pharma, S.A. | Fused oxazoles & thiazoles as histamine h3- receptor ligands |
| EP2079737A1 (en) * | 2007-02-05 | 2009-07-22 | Xenon Pharmaceuticals Inc. | Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions |
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| US8349846B2 (en) | 2013-01-08 |
| US20100292254A1 (en) | 2010-11-18 |
| JP2011509288A (ja) | 2011-03-24 |
| EA018133B1 (ru) | 2013-05-30 |
| EA201000674A1 (ru) | 2011-02-28 |
| EP2229388A2 (en) | 2010-09-22 |
| JP5419894B2 (ja) | 2014-02-19 |
| NZ595781A (en) | 2013-07-26 |
| WO2009109987A2 (en) | 2009-09-11 |
| EP2229388A4 (en) | 2012-03-07 |
| MX2010005769A (es) | 2010-11-12 |
| GEP20125574B (en) | 2012-07-10 |
| AU2009220825A2 (en) | 2012-04-19 |
| WO2009109987A3 (en) | 2009-12-17 |
| AU2009220825A1 (en) | 2012-01-19 |
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