AU2009220825A1 - Fused pyrimidine derivatives as TRPV3 modulators - Google Patents
Fused pyrimidine derivatives as TRPV3 modulators Download PDFInfo
- Publication number
- AU2009220825A1 AU2009220825A1 AU2009220825A AU2009220825A AU2009220825A1 AU 2009220825 A1 AU2009220825 A1 AU 2009220825A1 AU 2009220825 A AU2009220825 A AU 2009220825A AU 2009220825 A AU2009220825 A AU 2009220825A AU 2009220825 A1 AU2009220825 A1 AU 2009220825A1
- Authority
- AU
- Australia
- Prior art keywords
- substituted
- unsubstituted
- compound
- pyrido
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 102000003568 TRPV3 Human genes 0.000 title claims 3
- 101150043371 Trpv3 gene Proteins 0.000 title claims 3
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 49
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Classifications
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| IN798/MUM/2008 | 2008-04-04 | ||
| US4827608P | 2008-04-28 | 2008-04-28 | |
| US61/048,276 | 2008-04-28 | ||
| PCT/IN2009/000025 WO2009109987A2 (en) | 2008-01-11 | 2009-01-07 | Fused pyrimidine derivatives as trpv3 modulators |
Publications (2)
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| AU2009220825A1 true AU2009220825A1 (en) | 2012-01-19 |
| AU2009220825A2 AU2009220825A2 (en) | 2012-04-19 |
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| US8119647B2 (en) * | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
| MX2011006821A (es) | 2008-12-26 | 2012-01-03 | Glenmark Pharmaceuticals Sa | Derivados de imidazol fusionados como antagonistas de trpv3. |
| AR090789A1 (es) * | 2012-04-23 | 2014-12-10 | Genentech Inc | Intermediarios y procesos para la preparacion de compuestos |
| MX2022006370A (es) | 2019-11-25 | 2022-09-07 | Amgen Inc | Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso. |
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| US3907798A (en) * | 1966-06-15 | 1975-09-23 | Sterling Drug Inc | Preparation of 4H-pyrido{8 1,2-a{9 pyrimidin-4-ones from cyclic alkylidene 2-pyridylaminomethylenemalonates |
| HU168014B (enExample) * | 1973-03-30 | 1976-02-28 | ||
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| US4223031A (en) | 1978-05-05 | 1980-09-16 | Mead Johnson & Company | Azolopyrimidinones |
| IL59802A (en) * | 1979-05-08 | 1983-07-31 | Erba Farmitalia | Substituted pyrido(1,2-a)pyrimidine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
| AU551718B2 (en) | 1981-07-15 | 1986-05-08 | Farmitalia Carlo Erba S.P.A. | Substituted thiazolo(3,2-alpha)pyrimidines |
| US4537962A (en) | 1982-02-04 | 1985-08-27 | Farmitalia Carlo Erba, S.P.A. | Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions containing them |
| GB8300728D0 (en) | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
| US5204352A (en) | 1987-09-29 | 1993-04-20 | The United States Of America As Represented By The Secretary Of The Army | Compounds exhibiting anti-parasitic activity and a method for their use |
| US5252572A (en) * | 1988-02-03 | 1993-10-12 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. | Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same |
| IT1263804B (it) | 1993-01-22 | 1996-09-03 | Luso Farmaco Inst | Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista |
| ATE218139T1 (de) | 1994-02-23 | 2002-06-15 | Kyowa Hakko Kogyo Kk | Xanthin-derivate |
| JPH07242666A (ja) | 1994-03-08 | 1995-09-19 | Fujisawa Pharmaceut Co Ltd | 複素環化合物 |
| US6323208B1 (en) | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| ID23978A (id) | 1997-11-11 | 2000-06-14 | Pfizer Prod Inc | Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker |
| US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| BR0208338A (pt) * | 2001-03-26 | 2004-03-09 | Novartis Ag | Derivados de piridina |
| EP1687306A1 (en) * | 2003-11-14 | 2006-08-09 | MERCK SHARP & DOHME LTD. | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| US20060040944A1 (en) | 2004-06-23 | 2006-02-23 | Gilles Gosselin | 5-Aza-7-deazapurine derivatives for treating Flaviviridae |
| SI1706057T1 (sl) | 2004-08-18 | 2007-12-31 | Boettcher Robert | Privojni enosalni zobni vsadek |
| BRPI0514857A (pt) | 2004-09-03 | 2008-05-06 | Celgene Corp | composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central |
| US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| WO2006065686A2 (en) | 2004-12-13 | 2006-06-22 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
| US20080220968A1 (en) | 2005-07-05 | 2008-09-11 | Ge Healthcare Bio-Sciences Ab | [1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg |
| JP2009511465A (ja) | 2005-10-07 | 2009-03-19 | グレンマーク・ファーマシューティカルズ・エスエー | 置換ベンゾ縮合誘導体およびバニロイド受容体リガンドとしてのその使用 |
| US20100152209A1 (en) | 2005-11-04 | 2010-06-17 | Hydra Biosciences Inc. | Compounds for Modulating TRPV3 Function |
| GB0525069D0 (en) * | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| JP5858557B2 (ja) | 2005-12-22 | 2016-02-10 | ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | 疼痛を処置するためのｔｒｐａ１阻害剤 |
| US8980954B2 (en) | 2006-04-25 | 2015-03-17 | Stc.Unm | Substituted cis- and trans-stilbenes as therapeutic agents |
| WO2008001101A2 (en) | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2049548A1 (en) | 2006-07-27 | 2009-04-22 | UCB Pharma, S.A. | Fused oxazoles & thiazoles as histamine h3- receptor ligands |
| JP2010518026A (ja) | 2007-02-05 | 2010-05-27 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ナトリウムチャネルが介在する疾患または状態の治療に有用なピリドピリミジノン化合物 |
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Also Published As
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| EA018133B1 (ru) | 2013-05-30 |
| GEP20125574B (en) | 2012-07-10 |
| EP2229388A2 (en) | 2010-09-22 |
| NZ595781A (en) | 2013-07-26 |
| US20100292254A1 (en) | 2010-11-18 |
| EP2229388A4 (en) | 2012-03-07 |
| WO2009109987A2 (en) | 2009-09-11 |
| AU2009220825A2 (en) | 2012-04-19 |
| EA201000674A1 (ru) | 2011-02-28 |
| CA2724008A1 (en) | 2009-09-11 |
| US8349846B2 (en) | 2013-01-08 |
| MX2010005769A (es) | 2010-11-12 |
| JP5419894B2 (ja) | 2014-02-19 |
| WO2009109987A3 (en) | 2009-12-17 |
| JP2011509288A (ja) | 2011-03-24 |
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