GEP20125574B - Fused pyrimidine derivatives as trpv3 modulators - Google Patents

Fused pyrimidine derivatives as trpv3 modulators

Info

Publication number
GEP20125574B
GEP20125574B GEAP200911911A GEAP2009011911A GEP20125574B GE P20125574 B GEP20125574 B GE P20125574B GE AP200911911 A GEAP200911911 A GE AP200911911A GE AP2009011911 A GEAP2009011911 A GE AP2009011911A GE P20125574 B GEP20125574 B GE P20125574B
Authority
GE
Georgia
Prior art keywords
pyrimidine derivatives
fused pyrimidine
trpv3
trpv3 modulators
modulators
Prior art date
Application number
GEAP200911911A
Other languages
English (en)
Inventor
V S Prasadarao Lingam
Abraham Thomas
Joshi Neelima Khairatkar
Dattaguru Anandrao More
Javed Yusuf Khatik
Vidya Ganapati Kattige
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of GEP20125574B publication Critical patent/GEP20125574B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
GEAP200911911A 2008-01-11 2009-01-07 Fused pyrimidine derivatives as trpv3 modulators GEP20125574B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN82MU2008 2008-01-11
US2877008P 2008-02-14 2008-02-14
IN548MU2008 2008-03-18
IN798MU2008 2008-04-04
US4827608P 2008-04-28 2008-04-28

Publications (1)

Publication Number Publication Date
GEP20125574B true GEP20125574B (en) 2012-07-10

Family

ID=41056428

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP200911911A GEP20125574B (en) 2008-01-11 2009-01-07 Fused pyrimidine derivatives as trpv3 modulators

Country Status (10)

Country Link
US (1) US8349846B2 (enExample)
EP (1) EP2229388A4 (enExample)
JP (1) JP5419894B2 (enExample)
AU (1) AU2009220825A1 (enExample)
CA (1) CA2724008A1 (enExample)
EA (1) EA018133B1 (enExample)
GE (1) GEP20125574B (enExample)
MX (1) MX2010005769A (enExample)
NZ (1) NZ595781A (enExample)
WO (1) WO2009109987A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119647B2 (en) * 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators
NZ595775A (en) 2008-12-26 2013-07-26 Glenmark Pharmaceuticals Sa Fused imidazole derivatives as trpv3 antagonist
RU2635359C2 (ru) * 2012-04-23 2017-11-13 Дженентек Инк. Промежуточные химические соединения и способы получения соединений
MX2022006370A (es) 2019-11-25 2022-09-07 Amgen Inc Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso.

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HU168014B (enExample) * 1973-03-30 1976-02-28
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IL59802A (en) * 1979-05-08 1983-07-31 Erba Farmitalia Substituted pyrido(1,2-a)pyrimidine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
NL8202706A (nl) 1981-07-15 1983-02-01 Erba Farmitalia Gesubstitueerde thiazolo3,2-apyrimidinen en werkwijzen ter bereiding ervan.
US4537962A (en) 1982-02-04 1985-08-27 Farmitalia Carlo Erba, S.P.A. Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions containing them
GB8300728D0 (en) 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US5204352A (en) 1987-09-29 1993-04-20 The United States Of America As Represented By The Secretary Of The Army Compounds exhibiting anti-parasitic activity and a method for their use
US5252572A (en) * 1988-02-03 1993-10-12 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
IT1263804B (it) 1993-01-22 1996-09-03 Luso Farmaco Inst Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
WO1995023148A1 (en) 1994-02-23 1995-08-31 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivative
JPH07242666A (ja) 1994-03-08 1995-09-19 Fujisawa Pharmaceut Co Ltd 複素環化合物
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
SK6652000A3 (en) 1997-11-11 2002-05-09 Pfizer Prod Inc Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
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CZ20032561A3 (cs) * 2001-03-26 2003-12-17 Novartis Ag Deriváty pyridinu, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
EP1687306A1 (en) * 2003-11-14 2006-08-09 MERCK SHARP & DOHME LTD. Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1)
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JP4448170B2 (ja) 2004-08-18 2010-04-07 ベッチャー・ローベルト エノサル歯科インプラント
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US20060128710A1 (en) * 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
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EP1931681B1 (en) 2005-10-07 2012-11-14 Glenmark Pharmaceuticals S.A. Substituted benzofused derivatives and their use as vanilloid receptor ligands
US20100152209A1 (en) 2005-11-04 2010-06-17 Hydra Biosciences Inc. Compounds for Modulating TRPV3 Function
GB0525069D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
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JP2009542608A (ja) 2006-06-29 2009-12-03 アステックス・セラピューティクス・リミテッド 医薬組合せ剤
WO2008012010A1 (en) 2006-07-27 2008-01-31 Ucb Pharma, S.A. Fused oxazoles & thiazoles as histamine h3- receptor ligands
CA2677493A1 (en) 2007-02-05 2008-08-14 Xenon Pharmaceuticals Inc. Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions

Also Published As

Publication number Publication date
MX2010005769A (es) 2010-11-12
AU2009220825A2 (en) 2012-04-19
EA201000674A1 (ru) 2011-02-28
US8349846B2 (en) 2013-01-08
NZ595781A (en) 2013-07-26
EP2229388A2 (en) 2010-09-22
JP2011509288A (ja) 2011-03-24
CA2724008A1 (en) 2009-09-11
WO2009109987A3 (en) 2009-12-17
AU2009220825A1 (en) 2012-01-19
EA018133B1 (ru) 2013-05-30
JP5419894B2 (ja) 2014-02-19
US20100292254A1 (en) 2010-11-18
EP2229388A4 (en) 2012-03-07
WO2009109987A2 (en) 2009-09-11

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