CA2703002A1 - Bowel purgative and uses thereof - Google Patents
Bowel purgative and uses thereof Download PDFInfo
- Publication number
- CA2703002A1 CA2703002A1 CA2703002A CA2703002A CA2703002A1 CA 2703002 A1 CA2703002 A1 CA 2703002A1 CA 2703002 A CA2703002 A CA 2703002A CA 2703002 A CA2703002 A CA 2703002A CA 2703002 A1 CA2703002 A1 CA 2703002A1
- Authority
- CA
- Canada
- Prior art keywords
- ascorbic acid
- cleansing
- administered
- dry composition
- liters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008141 laxative Substances 0.000 title description 6
- 230000001543 purgative effect Effects 0.000 title description 6
- 239000000203 mixture Substances 0.000 claims abstract description 50
- 238000000034 method Methods 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000124008 Mammalia Species 0.000 claims abstract description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 74
- 235000010323 ascorbic acid Nutrition 0.000 claims description 37
- 239000011668 ascorbic acid Substances 0.000 claims description 37
- 229960005070 ascorbic acid Drugs 0.000 claims description 37
- 235000002639 sodium chloride Nutrition 0.000 claims description 25
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 229940083037 simethicone Drugs 0.000 claims description 18
- 239000002202 Polyethylene glycol Substances 0.000 claims description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 10
- 238000001839 endoscopy Methods 0.000 claims description 8
- 210000000936 intestine Anatomy 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 7
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000003792 electrolyte Substances 0.000 claims description 6
- 239000001103 potassium chloride Substances 0.000 claims description 6
- 235000011164 potassium chloride Nutrition 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- 238000002052 colonoscopy Methods 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 210000001072 colon Anatomy 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 238000002059 diagnostic imaging Methods 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 206010010774 Constipation Diseases 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 8
- -1 polyethylene Polymers 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000019399 Colonic disease Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000000799 cathartic agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940079360 enema for constipation Drugs 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 235000020888 liquid diet Nutrition 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008143 stimulant laxative Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98054307P | 2007-10-17 | 2007-10-17 | |
| US60/980,543 | 2007-10-17 | ||
| PCT/US2008/080116 WO2009052256A2 (en) | 2007-10-17 | 2008-10-16 | Bowel purgative and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2703002A1 true CA2703002A1 (en) | 2009-04-23 |
Family
ID=40568066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2703002A Abandoned CA2703002A1 (en) | 2007-10-17 | 2008-10-16 | Bowel purgative and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100297264A1 (enExample) |
| EP (1) | EP2211838A2 (enExample) |
| JP (1) | JP2011500711A (enExample) |
| CN (1) | CN101938994A (enExample) |
| AU (1) | AU2008312465A1 (enExample) |
| CA (1) | CA2703002A1 (enExample) |
| WO (1) | WO2009052256A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202010010312U1 (de) * | 2009-07-17 | 2010-11-04 | Norgine B.V. | Verbesserungen bei und bezüglich Kolonreinigungs-Zusammensetzungen |
| GB0912487D0 (en) * | 2009-07-17 | 2009-08-26 | Norgine Bv | Improvements in and relating to colon cleansing compositions |
| AU2011101324B4 (en) * | 2009-07-17 | 2012-01-19 | Norgine Bv | Improvements in and relating to colon cleansing compositions |
| ES2409842T3 (es) * | 2009-11-02 | 2013-06-28 | Promefarm S.R.L. | Composiciones para la limpieza intestinal y uso de las mismas |
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| CN102133225B (zh) * | 2011-03-18 | 2012-11-21 | 海南锦瑞制药股份有限公司 | 一种复方聚乙二醇电解质散剂及其制备方法 |
| JP2013049671A (ja) * | 2011-08-04 | 2013-03-14 | Fancl Corp | アスコルビン酸製剤 |
| US9149493B2 (en) | 2011-11-28 | 2015-10-06 | Alfa Wassermann Spa | Compositions for bowel cleansing and use thereof |
| SG10201702005VA (en) | 2012-09-11 | 2017-04-27 | Norgine Bv | Compositions comprising peg and ascorbate |
| DE102012024434A1 (de) * | 2012-12-14 | 2014-06-18 | Regalismons S.A. | Verstärkung der entschäumenden Wirkung von Polysiloxanen, zugehöriger Zusammensetzungen und Lösungen |
| SI2968174T1 (sl) | 2013-03-15 | 2020-02-28 | Braintree Laboratories, Inc. | Dvojna uporaba tablet oralnega farmacevtskega sestavka sulfatnih soli in metode njihove uporabe |
| WO2015056897A1 (ko) * | 2013-10-17 | 2015-04-23 | 강윤식 | 장 세정용 조성물 |
| KR101423005B1 (ko) | 2013-10-17 | 2014-07-28 | 강윤식 | 장 세정용 조성물 |
| CN107787223A (zh) * | 2015-06-22 | 2018-03-09 | 西梯茜生命工学股份有限公司 | 肠道清洁用泻剂组合物 |
| CN105055326B (zh) * | 2015-07-17 | 2018-02-06 | 西南大学 | 西甲硅油干混悬剂及其制备方法 |
| JP2018532702A (ja) * | 2015-09-01 | 2018-11-08 | コロナリーコンセプツ エルエルシー | 下剤製剤及び製造 |
| US12453742B2 (en) * | 2018-12-20 | 2025-10-28 | Zamir Brelvi | Bowel cleansing chemical composition and associated use therefore |
| US11298373B1 (en) * | 2018-12-20 | 2022-04-12 | Endologic Llc | Bowel cleansing chemical composition and associated use therefore |
| WO2022038643A1 (en) * | 2020-08-20 | 2022-02-24 | Biofarma S.r.l. | Composition and formulation for treating constipation and abdominal bloating |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU623627B2 (en) * | 1987-12-24 | 1992-05-21 | Thomas Julius Borody | Orthostatic lavage solutions |
| JP4092748B2 (ja) * | 1997-09-05 | 2008-05-28 | ニプロ株式会社 | 腸管洗浄液 |
| US7666337B2 (en) * | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| GB0224909D0 (en) * | 2002-10-25 | 2002-12-04 | Norgine Europe Bv | Colon cleansing compositions |
| DE10323216B3 (de) * | 2003-05-22 | 2004-12-23 | Siemens Ag | Endoskopieeinrichtung |
-
2008
- 2008-10-16 WO PCT/US2008/080116 patent/WO2009052256A2/en not_active Ceased
- 2008-10-16 CA CA2703002A patent/CA2703002A1/en not_active Abandoned
- 2008-10-16 CN CN2008801122687A patent/CN101938994A/zh active Pending
- 2008-10-16 JP JP2010530103A patent/JP2011500711A/ja active Pending
- 2008-10-16 AU AU2008312465A patent/AU2008312465A1/en not_active Abandoned
- 2008-10-16 EP EP08840765A patent/EP2211838A2/en not_active Withdrawn
- 2008-10-16 US US12/682,897 patent/US20100297264A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101938994A (zh) | 2011-01-05 |
| AU2008312465A1 (en) | 2009-04-23 |
| US20100297264A1 (en) | 2010-11-25 |
| EP2211838A2 (en) | 2010-08-04 |
| JP2011500711A (ja) | 2011-01-06 |
| WO2009052256A3 (en) | 2009-09-24 |
| WO2009052256A2 (en) | 2009-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20131004 |
|
| FZDE | Discontinued |
Effective date: 20151016 |