CA2696352C - Treating parasites with electric fields - Google Patents
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- CA2696352C CA2696352C CA2696352A CA2696352A CA2696352C CA 2696352 C CA2696352 C CA 2696352C CA 2696352 A CA2696352 A CA 2696352A CA 2696352 A CA2696352 A CA 2696352A CA 2696352 C CA2696352 C CA 2696352C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Electrotherapy Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
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| US95571907P | 2007-08-14 | 2007-08-14 | |
| US60/955,719 | 2007-08-14 | ||
| PCT/IB2008/002134 WO2009022225A1 (en) | 2007-08-14 | 2008-08-13 | Treating parasites with electric fields |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2696352A1 CA2696352A1 (en) | 2009-02-19 |
| CA2696352C true CA2696352C (en) | 2017-03-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2696352A Active CA2696352C (en) | 2007-08-14 | 2008-08-13 | Treating parasites with electric fields |
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| US (1) | US7890183B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2183024B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5485153B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101820947A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2696352C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2183024T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2739384T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2183024T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009022225A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| EP1259596A4 (en) | 2000-02-17 | 2004-12-22 | Novocure Limited | METHOD AND DEVICE FOR DESTROYING DIVIDING CELLS |
| US8175698B2 (en) * | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| DE10260149A1 (de) | 2002-12-20 | 2004-07-01 | BSH Bosch und Siemens Hausgeräte GmbH | Vorrichtung zur Bestimmung des Leitwertes von Wäsche, Wäschetrockner und Verfahren zur Verhinderung von Schichtbildung auf Elektroden |
| EP1740268A2 (en) | 2004-04-23 | 2007-01-10 | Standen Ltd. | Treating a tumor or the like with electric fields at different frequencies |
| PT1833552E (pt) * | 2004-12-07 | 2010-07-13 | Standen Ltd | ELéCTRODOS PARA APLICAR UM CAMPO ELéCTRICO IN-VIVO AO LONGO DE UM EXTENSO PERODO DE TEMPO |
| DK3804809T3 (da) * | 2005-10-03 | 2024-02-12 | Novocure Gmbh | Optimering af egenskaberne af et elektrisk felt for at øge feltets effekt på proliferende celler |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| US8892199B2 (en) * | 2006-10-18 | 2014-11-18 | Buckeye Pharmaceuticals | Chemical compound delivery device and method |
| EP3231480A1 (en) * | 2007-03-06 | 2017-10-18 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| CA2696352C (en) | 2007-08-14 | 2017-03-21 | Novocure Limited | Treating parasites with electric fields |
| US8992593B2 (en) * | 2007-12-26 | 2015-03-31 | Cook Medical Technologies Llc | Apparatus and methods for deployment of a modular stent-graft system |
| US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
| US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
| WO2013105987A2 (en) | 2011-02-15 | 2013-07-18 | Hemosonics, Llc | Characterization of blood hemostasis and oxygen transport parameters |
| EP2522389A3 (en) * | 2011-05-13 | 2014-08-27 | Sergio Lara Pereira Monteiro | Animal and plant cell electric stimulator with randomized spatial distribution of electrodes for both current injection and for electric field shaping |
| US9486625B2 (en) | 2011-08-08 | 2016-11-08 | Medamp Electronics, Llc | Method for treating benign prostate hyperplasia |
| US8706258B2 (en) | 2011-08-08 | 2014-04-22 | Medamp Electronics, Llc | Method and apparatus for treating cancer |
| DE102012015482A1 (de) * | 2012-08-07 | 2014-02-13 | Cinogy Gmbh | Elektrodenanordnung für ein behindertes Plasma |
| DE102012025052A1 (de) * | 2012-12-20 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Hämodiafiltrationsverfahren |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US20190117963A1 (en) * | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) * | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| KR102555691B1 (ko) | 2016-06-30 | 2023-07-13 | 노보큐어 리미티드 | 신체에 대한 종양 치료장의 길이 방향 전달을 위한 어레이들 |
| ES2968148T3 (es) | 2016-11-24 | 2024-05-08 | Public Univ Corp Yokohama City Univ | Aparato para el tratamiento del cáncer |
| CA3049949C (en) | 2017-01-19 | 2024-04-23 | Novocure Limited | System for viewing cell cultures under a microscope whilst applying tumor treating fields |
| US11364390B2 (en) * | 2017-02-07 | 2022-06-21 | Santi Tofani | Apparatus for treating pathological cells |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| JP7139448B2 (ja) | 2018-04-09 | 2022-09-20 | ノボキュア ゲーエムベーハー | ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療 |
| US11650277B2 (en) | 2018-04-10 | 2023-05-16 | Novocure Gmbh | TTField treatment with optimization of electrode positions based on low frequency (<1MHZ) AC conductivity estimates derived from two MRI images having different repetition times |
| WO2020010188A1 (en) | 2018-07-03 | 2020-01-09 | Edwin Chang | Using alternating electric fields to increase cell membrane permeability |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| WO2020012364A1 (en) | 2018-07-10 | 2020-01-16 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
| JP7267393B2 (ja) | 2018-07-18 | 2023-05-01 | ノボキュア ゲーエムベーハー | 腫瘍治療場（ｔｔ場）の線量を定量化するための電力損失密度および関連する処置の使用 |
| IL319986A (en) * | 2018-08-23 | 2025-06-01 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| CN112770806B (zh) | 2018-09-07 | 2025-12-05 | 诺沃库勒有限责任公司 | 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖 |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| CN112930209B (zh) | 2018-10-15 | 2024-10-15 | 诺沃库勒有限责任公司 | 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields)的装置和方法 |
| US11369790B2 (en) * | 2018-10-25 | 2022-06-28 | Novocure Gmbh | Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy |
| EP3880299B1 (en) | 2018-11-13 | 2025-09-24 | The Methodist Hospital | Device for oncomagnetic treatment |
| ES2976808T3 (es) | 2018-11-19 | 2024-08-08 | Novocure Gmbh | Matrices para la administración de campos de tratamiento de tumores (TTFields) con subelementos selectivamente direccionables |
| KR102721377B1 (ko) | 2018-11-29 | 2024-10-23 | 노보큐어 게엠베하 | 종양처리장을 전달하는 향상된 유연성 트랜스듀서 어레이 |
| EP3961565A1 (en) | 2019-01-08 | 2022-03-02 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| JP2022519782A (ja) | 2019-02-07 | 2022-03-24 | ヴィヴェーク・ケー・シャルマ | 交番極性磁場によってがん細胞を治療するシステム、および方法 |
| US11344740B2 (en) | 2019-02-07 | 2022-05-31 | Asha Medical, Inc. | System and methods for treating cancer cells with alternating polarity magnetic fields |
| US11027143B2 (en) | 2020-02-06 | 2021-06-08 | Vivek K. Sharma | System and methods for treating cancer cells with alternating polarity magnetic fields |
| US11554262B2 (en) | 2019-02-26 | 2023-01-17 | Novocure Gmbh | Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells |
| EP3917423B1 (en) | 2019-02-27 | 2024-11-13 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| FR3093645B1 (fr) * | 2019-03-15 | 2021-04-02 | Univ Montpellier | Puce microfluidique pour attirer et détruire un élément biologique spécifique |
| PL3946322T3 (pl) | 2019-03-29 | 2024-02-26 | Novocure Gmbh | Sposoby przywracania wrażliwości na ttfields w komórkach nowotworowych opornych wobec ttfields, z inhibitorami ptger3 |
| PL3960232T3 (pl) | 2019-04-17 | 2023-05-15 | Novocure Gmbh | Załadowanie danych z układu izolowanego bez naruszania izolacji |
| WO2020219339A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| EP3958959B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Devices for administering electrical stimulation to treat cancer |
| WO2020219336A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation devices for cancer treatment |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| JP7476231B2 (ja) | 2019-04-23 | 2024-04-30 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 温熱療法又は熱モニタと共に行われる電気刺激 |
| JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド，インコーポレイテッド | がん治療のための電気刺激用電極 |
| US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
| JP2022545344A (ja) | 2019-08-05 | 2022-10-27 | ノボキュア ゲーエムベーハー | Ｉｌ１１活性を阻害することによって、腫瘍治療電場（ｔｔフィールド）に対するがん細胞の感受性を高める |
| CN114364433A (zh) | 2019-08-30 | 2022-04-15 | 诺沃库勒有限责任公司 | 向颈部输送肿瘤治疗场（TTFields） |
| US12076556B2 (en) * | 2019-12-11 | 2024-09-03 | Novocure Gmbh | Compositions and methods of altering the electric impedance to an alternating electric field |
| WO2021137094A1 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors |
| US12121739B2 (en) * | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| EP4074369A1 (en) | 2019-12-31 | 2022-10-19 | Novocure GmbH | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| US20210299440A1 (en) | 2020-03-30 | 2021-09-30 | Novocure Gmbh | Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases |
| EP4138988A1 (en) | 2020-04-24 | 2023-03-01 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| TWI889816B (zh) | 2020-05-06 | 2025-07-11 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
| EP4168108A4 (en) | 2020-06-19 | 2024-07-17 | The Methodist Hospital dba Houston Methodist Hospital | METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| KR102490645B1 (ko) * | 2020-07-16 | 2023-01-25 | 고려대학교 산학협력단 | 흡수에너지 기반 전기장 암치료 계획 시스템 및 방법 |
| EP4223363B1 (en) | 2020-09-25 | 2024-04-24 | Novocure GmbH | Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating |
| DE102021102884A1 (de) * | 2021-02-08 | 2022-08-11 | Elea Vertriebs- Und Vermarktungsgesellschaft Mbh | Verfahren zum Paralysieren von Parasiten in Nahrung, insbesondere in einem Lebens- oder Futtermittel und damit hergestelltes Lebensmittel mit paralysierten Parasiten |
| EP4240470A1 (en) | 2021-02-17 | 2023-09-13 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
| US12440680B2 (en) | 2021-03-12 | 2025-10-14 | Novocure Gmbh | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| US20220305277A1 (en) * | 2021-03-23 | 2022-09-29 | Novocure Gmbh | Methods and apparatuses for detecting and responding to changes in a subject |
| JP2024513854A (ja) | 2021-03-31 | 2024-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）システムの電極を使用したインピーダンス断層撮影法 |
| CN117858741A (zh) | 2021-06-22 | 2024-04-09 | 利弗布里奇创新公共福利公司 | 用于改善电场治疗以减少实体肿瘤的装置和方法 |
| WO2023275804A1 (en) * | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Using alternating electric fields at different frequencies to increase the permeability of the blood brain barrier and also to provide other benefits |
| CN113663215B (zh) * | 2021-10-22 | 2022-01-21 | 杭州维纳安可医疗科技有限责任公司 | 电场发生装置及其控制方法、计算机可读存储介质 |
| US20230173265A1 (en) * | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
| WO2023126855A1 (en) | 2021-12-30 | 2023-07-06 | Novocure Gmbh | Selecting values of parameters for treatment using tumor treating fields (ttfields) |
| IL314392A (en) | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| JP2025511071A (ja) | 2022-03-30 | 2025-04-15 | ノボキュア ゲーエムベーハー | インターリーブ冷却期間による腫瘍治療場のピーク強度強化 |
| US12420113B2 (en) | 2022-04-01 | 2025-09-23 | The Board Of Regents Of The University Of Texas System | Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy |
| WO2024141916A1 (en) * | 2022-12-28 | 2024-07-04 | Novocure Gmbh | Wearable garment with integrated tumor treating fields voltage generator |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN116020054B (zh) * | 2023-02-24 | 2023-12-08 | 北京微脊医疗科技有限公司 | 植入式电场治疗装置 |
| US12465759B2 (en) | 2023-03-14 | 2025-11-11 | Boris Kriman | Electrostatic therapeutic device |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR446660A (fr) | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4121592A (en) | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
| JPS5547870A (en) | 1978-02-24 | 1980-04-05 | Lawrence Joseph L | Medical treatment method |
| DE2813068A1 (de) | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| US4472506A (en) | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| US4467809A (en) | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4622952A (en) | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
| CA1244889A (en) | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| DE3323415C2 (de) | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
| SE455920B (sv) | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
| US4923814A (en) | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
| CN86103803B (zh) | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
| US4822470A (en) | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
| US4936303A (en) | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
| JPH0629196B2 (ja) | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| US5158071A (en) | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| GB8904998D0 (en) | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
| US5099756A (en) | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
| US5441746A (en) | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
| US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| CA2109084C (en) | 1991-05-03 | 2004-02-24 | John William Fisher Costerton | Biofilm reduction method |
| US5441532A (en) | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
| US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704355A (en) | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
| AU6639596A (en) | 1995-07-28 | 1997-02-26 | James R. Gray | Use of a polarizing field to modify the efficacy of a bioactive agent |
| US5606971A (en) | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
| US5718246A (en) | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6043066A (en) | 1997-09-04 | 2000-03-28 | Mangano; Joseph A. | Cell separation using electric fields |
| US6027488A (en) | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US5976092A (en) | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| AU779100B2 (en) | 1999-03-09 | 2005-01-06 | Thermage, Inc. | Apparatus and method for treatment of tissue |
| US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| EP1259596A4 (en) | 2000-02-17 | 2004-12-22 | Novocure Limited | METHOD AND DEVICE FOR DESTROYING DIVIDING CELLS |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US8986944B2 (en) * | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| EP1740268A2 (en) | 2004-04-23 | 2007-01-10 | Standen Ltd. | Treating a tumor or the like with electric fields at different frequencies |
| DE102004028156A1 (de) | 2004-06-09 | 2006-01-05 | Kalbe, Jochen, Dr. | Kombination von Radiowellen mit pharmakologisch aktiven Substanzen |
| PT1833552E (pt) | 2004-12-07 | 2010-07-13 | Standen Ltd | ELéCTRODOS PARA APLICAR UM CAMPO ELéCTRICO IN-VIVO AO LONGO DE UM EXTENSO PERODO DE TEMPO |
| JP5559460B2 (ja) * | 2004-12-27 | 2014-07-23 | スタンデン・リミテッド | 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法 |
| ES2651812T3 (es) | 2005-06-08 | 2018-01-29 | Novocure Limited | Aparato para tratar el cáncer con campos eléctricos que se guían a las localizaciones deseadas dentro de un cuerpo |
| DK3804809T3 (da) | 2005-10-03 | 2024-02-12 | Novocure Gmbh | Optimering af egenskaberne af et elektrisk felt for at øge feltets effekt på proliferende celler |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| EP3231480A1 (en) | 2007-03-06 | 2017-10-18 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| CA2696352C (en) | 2007-08-14 | 2017-03-21 | Novocure Limited | Treating parasites with electric fields |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
-
2008
- 2008-08-13 CA CA2696352A patent/CA2696352C/en active Active
- 2008-08-13 US US12/190,886 patent/US7890183B2/en not_active Expired - Lifetime
- 2008-08-13 JP JP2010520642A patent/JP5485153B2/ja active Active
- 2008-08-13 WO PCT/IB2008/002134 patent/WO2009022225A1/en not_active Ceased
- 2008-08-13 EP EP08789083.6A patent/EP2183024B1/en active Active
- 2008-08-13 CN CN200880111479A patent/CN101820947A/zh active Pending
- 2008-08-13 ES ES08789083T patent/ES2739384T3/es active Active
- 2008-08-13 DK DK08789083.6T patent/DK2183024T3/da active
- 2008-08-13 PT PT08789083T patent/PT2183024T/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009022225A1 (en) | 2009-02-19 |
| US20090043346A1 (en) | 2009-02-12 |
| PT2183024T (pt) | 2019-08-01 |
| EP2183024A1 (en) | 2010-05-12 |
| ES2739384T3 (es) | 2020-01-30 |
| CA2696352A1 (en) | 2009-02-19 |
| CN101820947A (zh) | 2010-09-01 |
| DK2183024T3 (da) | 2019-06-24 |
| JP5485153B2 (ja) | 2014-05-07 |
| EP2183024B1 (en) | 2019-05-15 |
| JP2010536406A (ja) | 2010-12-02 |
| US7890183B2 (en) | 2011-02-15 |
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