CA2692546C - Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery - Google Patents

Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery Download PDF

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CA2692546C
CA2692546C CA2692546A CA2692546A CA2692546C CA 2692546 C CA2692546 C CA 2692546C CA 2692546 A CA2692546 A CA 2692546A CA 2692546 A CA2692546 A CA 2692546A CA 2692546 C CA2692546 C CA 2692546C
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nucleic acid
cationic liposome
ligand
acid molecules
viral proteins
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French (fr)
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CA2692546A1 (en
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Esther H. Chang
Kathleen F. Pirollo
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Georgetown University
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Georgetown University
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A—HUMAN NECESSITIES
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    • C12N2810/00—Vectors comprising a targeting moiety
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    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

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CA2692546A 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery Active CA2692546C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92968507P 2007-07-09 2007-07-09
US60/929,685 2007-07-09
PCT/US2008/008394 WO2009009054A1 (en) 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery

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CA2692546A1 CA2692546A1 (en) 2009-01-15
CA2692546C true CA2692546C (en) 2018-03-13

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CA2692546A Active CA2692546C (en) 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery

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US (1) US20090053299A1 (enExample)
EP (1) EP2175835B1 (enExample)
JP (2) JP5890095B2 (enExample)
KR (2) KR101570886B1 (enExample)
CN (2) CN106890142A (enExample)
AU (1) AU2008275713B2 (enExample)
BR (1) BRPI0814558A2 (enExample)
CA (1) CA2692546C (enExample)
EA (1) EA201070050A1 (enExample)
IL (1) IL203204B (enExample)
MX (1) MX2010000166A (enExample)
NZ (1) NZ582414A (enExample)
SG (1) SG182994A1 (enExample)
WO (1) WO2009009054A1 (enExample)
ZA (1) ZA201000038B (enExample)

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RS63890B1 (sr) * 2010-08-31 2023-02-28 Glaxosmithkline Biologicals Sa Mali lipozomi za isporuku rnk koja kodira imunogen
US8932575B2 (en) 2010-09-21 2015-01-13 University Of Miami Compositions and methods for inducing migration by dendritic cells and an immune response
WO2012040266A2 (en) * 2010-09-24 2012-03-29 University Of Miami Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
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CN103405386B (zh) * 2012-09-21 2016-05-18 上海泽润生物科技有限公司 一种脂质体的制备方法及制作脂质体佐剂的方法
WO2014159917A2 (en) 2013-03-14 2014-10-02 Georgetown University Treatment for exposure to nerve agent
CN105726485B (zh) * 2016-03-24 2019-08-06 东华大学 一种半乳糖化壳聚糖修饰的免疫醇质体的制备方法
CA3121247A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
CN111840538A (zh) * 2020-05-29 2020-10-30 中山大学 一种水痘-带状疱疹病毒亚单位纳米疫苗的制备方法和应用
WO2022051023A1 (en) * 2020-09-04 2022-03-10 Infectious Disease Research Institute Live-attenuated rna hybrid vaccine technology
CN117883382B (zh) * 2023-11-27 2025-02-14 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 高效递送疫苗的脂质体载体及脂质体疫苗的制备与用途

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KR20100044206A (ko) 2010-04-29
IL203204B (en) 2018-05-31
US20090053299A1 (en) 2009-02-26
ZA201000038B (en) 2011-03-30
EP2175835A1 (en) 2010-04-21
CA2692546A1 (en) 2009-01-15
MX2010000166A (es) 2010-04-27
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BRPI0814558A2 (pt) 2015-01-06
EA201070050A1 (ru) 2010-10-29
CN101801344A (zh) 2010-08-11
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AU2008275713B2 (en) 2014-08-07
KR20150108948A (ko) 2015-09-30
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JP5890095B2 (ja) 2016-03-22
AU2008275713A1 (en) 2009-01-15
WO2009009054A1 (en) 2009-01-15

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