CA2691587C - Potentiation of cancer chemotherapy by 7-(2,5-dihydro-4-imidazo [1,2-a] pyrine-3-yl-2,5-dioxo-ih-pyrrol-3-yl)-9-fluoro-1,2,3,4, tetrahydro-2-(1-piperidinyl-carbonyd-pyrrolo[3,2,1-jk][1,4]benzodiazepin - Google Patents
Potentiation of cancer chemotherapy by 7-(2,5-dihydro-4-imidazo [1,2-a] pyrine-3-yl-2,5-dioxo-ih-pyrrol-3-yl)-9-fluoro-1,2,3,4, tetrahydro-2-(1-piperidinyl-carbonyd-pyrrolo[3,2,1-jk][1,4]benzodiazepin Download PDFInfo
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- CA2691587C CA2691587C CA2691587A CA2691587A CA2691587C CA 2691587 C CA2691587 C CA 2691587C CA 2691587 A CA2691587 A CA 2691587A CA 2691587 A CA2691587 A CA 2691587A CA 2691587 C CA2691587 C CA 2691587C
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- Prior art keywords
- compound
- fluoro
- imidazo
- dihydro
- cancer
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94751207P | 2007-07-02 | 2007-07-02 | |
| US60/947,512 | 2007-07-02 | ||
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| TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
| US8802668B2 (en) | 2009-04-14 | 2014-08-12 | Eli Lilly And Company | Hematopoietic neoplasm chemotherapy |
| JP2014531456A (ja) * | 2011-09-22 | 2014-11-27 | バインド セラピューティックス インコーポレイテッド | 治療用ナノ粒子と癌を治療する方法 |
| WO2014050779A1 (ja) * | 2012-09-25 | 2014-04-03 | 第一三共株式会社 | Ｇｓｋ３阻害剤と抗ｄｒ５抗体の組み合わせ |
| CN107613983B (zh) * | 2015-04-30 | 2021-05-04 | 大鹏药品工业株式会社 | 抗肿瘤剂的副作用减轻剂 |
| US10213511B2 (en) * | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10016507B2 (en) * | 2016-03-02 | 2018-07-10 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| CN110392686A (zh) * | 2016-12-30 | 2019-10-29 | 频率治疗公司 | 1h-吡咯-2,5-二酮化合物以及使用它们来诱导干/祖支持细胞自我更新的方法 |
| JP2022520671A (ja) | 2019-02-08 | 2022-03-31 | フリークエンシー・セラピューティクス・インコーポレイテッド | 耳障害を治療するためのバルプロ酸化合物及びｗｎｔ作動薬 |
| CA3222225A1 (en) * | 2021-06-03 | 2022-12-08 | University Of Cincinnati | Bzd-1 as a chemosensitizer of cancer |
| CN113956157B (zh) * | 2021-11-18 | 2024-05-03 | 西安都创医药科技有限公司 | 一种合成2-甲酰基-1-环丙烷甲酸乙酯的方法 |
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| GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| EP1788086A1 (en) * | 1997-03-17 | 2007-05-23 | Human Genome Sciences, Inc. | Death Domain Containing Receptor 5 |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| KR100974770B1 (ko) * | 2002-03-05 | 2010-08-06 | 일라이 릴리 앤드 캄파니 | 키나제 억제제로서의 퓨린 유도체 |
| CA2499639C (en) * | 2002-09-19 | 2011-11-08 | Schering Corporation | Imidazopyridines as cyclin dependent kinase inhibitors |
| US20110293746A1 (en) * | 2004-07-09 | 2011-12-01 | Agency For Science, Technology And Research | Modulation of Gsk-3Beta and Method of Treating Proliferative Disorders |
| GB0418328D0 (en) * | 2004-08-17 | 2004-09-22 | Imp College Innovations Ltd | Cancer methods and medicaments |
| US20060252082A1 (en) * | 2005-05-04 | 2006-11-09 | University Of South Florida | Predicting treatment response in cancer subjects |
| TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
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