CA2681531C - Immunoglobulin heavy chains comprising heterologous t-cell epitopes - Google Patents
Immunoglobulin heavy chains comprising heterologous t-cell epitopes Download PDFInfo
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- CA2681531C CA2681531C CA2681531A CA2681531A CA2681531C CA 2681531 C CA2681531 C CA 2681531C CA 2681531 A CA2681531 A CA 2681531A CA 2681531 A CA2681531 A CA 2681531A CA 2681531 C CA2681531 C CA 2681531C
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- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| GBGB0706070.0A GB0706070D0 (en) | 2007-03-28 | 2007-03-28 | Nucleic acids |
| GB0706070.0 | 2007-03-28 | ||
| PCT/EP2008/053761 WO2008116937A2 (en) | 2007-03-28 | 2008-03-28 | Nucleic acids |
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| CA2681531A1 CA2681531A1 (en) | 2008-10-02 |
| CA2681531C true CA2681531C (en) | 2017-11-28 |
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| CA2681531A Active CA2681531C (en) | 2007-03-28 | 2008-03-28 | Immunoglobulin heavy chains comprising heterologous t-cell epitopes |
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| GB0706070D0 (en) | 2007-03-28 | 2007-05-09 | Scancell Ltd | Nucleic acids |
| GB201214007D0 (en) | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
| EP3253419A1 (en) | 2015-02-02 | 2017-12-13 | The University of Birmingham | Targeting moiety peptide epitope complexes having a plurality of t-cell epitopes |
| WO2017210149A1 (en) * | 2016-05-31 | 2017-12-07 | Igc Bio, Inc. | Compositions and methods for generating an antibody library |
| US11419928B2 (en) | 2017-10-25 | 2022-08-23 | The Johns Hopkins University | Methods and compositions for treating cancer |
| GB201815041D0 (en) | 2018-09-14 | 2018-10-31 | Scancell Ltd | Epitopes |
| WO2021195089A1 (en) | 2020-03-23 | 2021-09-30 | Sorrento Therapeutics, Inc. | Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof |
| CN111423504B (zh) * | 2020-04-17 | 2021-03-26 | 安徽高安生物医学科技有限公司 | 黑色素瘤特异性抗原肽、肽复合物以及人工抗原呈递细胞 |
| BR112023002195A2 (pt) | 2020-08-26 | 2023-03-14 | Scancell Ltd | Ácido nucleico que codifica um polipeptídeo, vetor, peptídeo, e composição de vacina |
| GB202314361D0 (en) * | 2023-09-19 | 2023-11-01 | Scancell Ltd | Vaccine compositions and uses thereof |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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| BR9815289A (pt) * | 1997-11-14 | 2001-12-26 | Euro Celtique Sa | Imunoglobulina modificada, molécula, ácidonucleico isolado, célula contendo o mesmo, animalnão-humano recombinante, composiçãofarmacêutica, composição de vacina, processospara identificar ou medir ou detectar um antìgenode câncer, um antìgeno de um agente de doençainfecciosa, um ligante, e um receptor em umaamostra a ser testada, kits para detecção de umantìgeno de câncer, de um antìgeno de um agentede doença infecciosa, de um receptor celular paraum agente de doença infecciosa, de um ligante, e deum antìgeno de câncer, processos de diagnósticoou de exame para a presença de ou umapredisposição para desenvolvimento de um câncertipificado pela presença aumentada de umantìgeno de câncer, e para a presença de umagente de doença infecciosa, processos detratamento ou de prevenção de um câncertipificado pela presença de um antìgeno de câncer,de uma doença infecciosa tipificada pela presençade um antìgeno de agente de doença infecciosa, ede uma doença causada por um agente de doençainfecciosa que se liga em um receptor celular,processos para modulação de atividade de umprimeiro membro de um par de ligação, processo deprodução de uma imunoglobulina modificada,processo de produção de um ácido nucleicocodificador de imunoglobulina modificada, e, ácidonucleico isolado |
| EP1181320B1 (en) * | 1999-04-27 | 2011-03-09 | Nevagen LLC | Somatic transgene immunization and related methods |
| US7067110B1 (en) * | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| GB0102145D0 (en) * | 2001-01-26 | 2001-03-14 | Scancell Ltd | Substances |
| GB0111628D0 (en) | 2001-05-11 | 2001-07-04 | Scancell Ltd | Binding member |
| AU2002331704A1 (en) * | 2001-08-22 | 2003-03-10 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health A | Peptides of melanoma antigen and their use in diagnostic, prophylactic and therapeutic methods |
| EP1556072B1 (en) * | 2002-09-17 | 2010-05-19 | Antigen Express, Inc. | Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES |
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| GB0706070D0 (en) | 2007-05-09 |
| KR20170040387A (ko) | 2017-04-12 |
| EP2134357A2 (en) | 2009-12-23 |
| JP2010522550A (ja) | 2010-07-08 |
| CA2681531A1 (en) | 2008-10-02 |
| US8742088B2 (en) | 2014-06-03 |
| DK2193803T3 (da) | 2012-02-13 |
| WO2008116937A2 (en) | 2008-10-02 |
| PL2134357T3 (pl) | 2018-03-30 |
| CN101678092B (zh) | 2014-04-02 |
| CN103667304A (zh) | 2014-03-26 |
| KR20150013357A (ko) | 2015-02-04 |
| EP2193803B1 (en) | 2011-10-19 |
| KR101729458B1 (ko) | 2017-04-21 |
| WO2008116937A3 (en) | 2009-01-22 |
| ATE529128T1 (de) | 2011-11-15 |
| PT2193803E (pt) | 2012-01-16 |
| BRPI0808599A2 (pt) | 2019-01-08 |
| EP2134357B1 (en) | 2017-05-31 |
| JP5415399B2 (ja) | 2014-02-12 |
| ZA200907242B (en) | 2010-11-24 |
| KR20100015699A (ko) | 2010-02-12 |
| PT2134357T (pt) | 2017-08-29 |
| ES2638188T3 (es) | 2017-10-19 |
| EP2193803A1 (en) | 2010-06-09 |
| DK2134357T3 (en) | 2017-09-11 |
| ES2375463T3 (es) | 2012-03-01 |
| CN103667304B (zh) | 2018-02-02 |
| US20100260806A1 (en) | 2010-10-14 |
| CN101678092A (zh) | 2010-03-24 |
| AU2008231723B2 (en) | 2013-05-16 |
| KR20160091458A (ko) | 2016-08-02 |
| AU2008231723A1 (en) | 2008-10-02 |
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