CA2679882C - Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof - Google Patents
Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof Download PDFInfo
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- CA2679882C CA2679882C CA2679882A CA2679882A CA2679882C CA 2679882 C CA2679882 C CA 2679882C CA 2679882 A CA2679882 A CA 2679882A CA 2679882 A CA2679882 A CA 2679882A CA 2679882 C CA2679882 C CA 2679882C
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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| US90596307P | 2007-03-08 | 2007-03-08 | |
| US60/905,963 | 2007-03-08 | ||
| PCT/US2008/003092 WO2008112164A2 (en) | 2007-03-08 | 2008-03-07 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
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| CA2679882A1 CA2679882A1 (en) | 2008-09-18 |
| CA2679882C true CA2679882C (en) | 2015-12-29 |
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| AU (1) | AU2008226947B2 (OSRAM) |
| CA (1) | CA2679882C (OSRAM) |
| WO (1) | WO2008112164A2 (OSRAM) |
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| AU2008226947B2 (en) | 2007-03-08 | 2014-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| CN102209541B (zh) | 2008-09-08 | 2016-05-18 | 小利兰·斯坦福大学托管委员会 | 醛脱氢酶活性调节剂和其使用方法 |
| US8389522B2 (en) | 2008-10-28 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
| US20140088187A1 (en) * | 2010-12-14 | 2014-03-27 | Beth Israel Deaconess Medical Center | Androgen receptor inhibitors and methods of use thereof |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| WO2014031982A2 (en) * | 2012-08-24 | 2014-02-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating pain |
| WO2014160185A2 (en) | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| CN103191103A (zh) * | 2013-04-15 | 2013-07-10 | 中南大学 | 乙醛脱氢酶激活物alda-1的合成方法及其用途 |
| CN103923077B (zh) * | 2013-07-05 | 2016-03-02 | 高尔医药科技(上海)有限公司 | 两种乙醛脱氢酶激动剂、其制备方法及用途 |
| JP6261278B2 (ja) * | 2013-10-16 | 2018-01-17 | 国立大学法人広島大学 | アルデヒドデヒドロゲナーゼの活性を増強するための医薬組成物 |
| WO2015084731A1 (en) * | 2013-12-02 | 2015-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Aldehyde dehydrogenase inhibitors and methods of use thereof |
| CA2940269C (en) * | 2014-02-19 | 2022-08-16 | Aviv Therapeutics, Inc. | Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer |
| FR3054564B1 (fr) | 2016-07-28 | 2018-08-31 | Advanced Biodesign | Substrat specifique d'une isoenzyme de l'aldh |
| WO2019098288A1 (ja) * | 2017-11-15 | 2019-05-23 | 学校法人 慶應義塾 | 抗腫瘍剤及び配合剤 |
| KR20200115474A (ko) | 2018-01-31 | 2020-10-07 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Aldh2 활성화제 |
| CN108864034A (zh) * | 2018-06-04 | 2018-11-23 | 中国人民解放军第二军医大学 | 酰胺类醛脱氢酶激动剂、其合成方法及用途 |
| CN111909138A (zh) * | 2019-05-09 | 2020-11-10 | 上海仕谱生物科技有限公司 | 抑制tdg活性的化合物 |
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| MX2023002714A (es) | 2020-11-02 | 2023-03-28 | Alchemedicine Inc | Compuesto, agente de activacion de aldehido deshidrogenasa 2, composicion farmaceutica y farmaco terapeutico y/o profilactico. |
| MX2024007847A (es) | 2022-04-22 | 2024-07-09 | Alchemedicine Inc | Compuesto, activador de la aldehido deshidrogenasa 2 (aldh2), composicion farmaceutica y farmaco terapeutico y/o profilactico. |
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2011
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2014
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Also Published As
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| KR20090117950A (ko) | 2009-11-16 |
| US20150105456A1 (en) | 2015-04-16 |
| US20120010248A1 (en) | 2012-01-12 |
| US9102651B2 (en) | 2015-08-11 |
| CA2679882A1 (en) | 2008-09-18 |
| JP2010523476A (ja) | 2010-07-15 |
| US20090082431A1 (en) | 2009-03-26 |
| CN101669030A (zh) | 2010-03-10 |
| EP2126574A4 (en) | 2012-02-22 |
| AU2008226947B2 (en) | 2014-07-17 |
| EP2126574B1 (en) | 2015-12-23 |
| WO2008112164A2 (en) | 2008-09-18 |
| US9315484B2 (en) | 2016-04-19 |
| JP2015061836A (ja) | 2015-04-02 |
| AU2008226947A1 (en) | 2008-09-18 |
| CN101669030B (zh) | 2016-01-13 |
| US20110105602A2 (en) | 2011-05-05 |
| EP2126574A2 (en) | 2009-12-02 |
| WO2008112164A3 (en) | 2008-11-13 |
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