CA2676008A1 - Compositions and methods for diagnosing and treating cancer - Google Patents
Compositions and methods for diagnosing and treating cancer Download PDFInfo
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- CA2676008A1 CA2676008A1 CA002676008A CA2676008A CA2676008A1 CA 2676008 A1 CA2676008 A1 CA 2676008A1 CA 002676008 A CA002676008 A CA 002676008A CA 2676008 A CA2676008 A CA 2676008A CA 2676008 A1 CA2676008 A1 CA 2676008A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Oncology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
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| US88641407P | 2007-01-24 | 2007-01-24 | |
| US60/886,414 | 2007-01-24 | ||
| PCT/US2008/000884 WO2008091641A2 (en) | 2007-01-24 | 2008-01-24 | Compositions and methods for diagnosing and treating cancer |
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| CA2676008A1 true CA2676008A1 (en) | 2008-07-31 |
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| EP (1) | EP2125887A4 (enExample) |
| JP (1) | JP5618544B2 (enExample) |
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| CA (1) | CA2676008A1 (enExample) |
| WO (1) | WO2008091641A2 (enExample) |
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| US7906116B2 (en) * | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
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| CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| BRPI0914007A2 (pt) | 2008-07-08 | 2015-11-17 | Oncomed Pharm Inc | anatagonistas e agentes de ligação de notch e métodos para uso dos mesmos |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| US9475855B2 (en) * | 2008-08-22 | 2016-10-25 | The Trustees Of Columbia University In The City Of New York | Human Notch3 based fusion proteins as decoy inhibitors of Notch3 signaling |
| JP5710487B2 (ja) * | 2008-10-01 | 2015-04-30 | ジェネンテック， インコーポレイテッド | 抗ｎｏｔｃｈ２抗体および使用方法 |
| WO2010141249A2 (en) * | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-notch3 antibodies |
| AU2010300747A1 (en) * | 2009-09-30 | 2012-04-26 | Genentech, Inc. | Treating Notch1-antagonist-resistant cancer (s) using Notch3 antagonists |
| ES2561102T3 (es) | 2010-01-13 | 2016-02-24 | Oncomed Pharmaceuticals, Inc. | Agentes de unión a Notch1 y procedimientos de uso de los mismos |
| WO2012003472A1 (en) * | 2010-07-02 | 2012-01-05 | Aveo Pharmaceuticals, Inc. | Anti-notch1 antibodies |
| AR088048A1 (es) * | 2011-10-04 | 2014-05-07 | Univ Columbia | Señuelos notch1 humanos |
| US9352039B2 (en) | 2012-02-09 | 2016-05-31 | The Regents Of The University Of Michigan | Method of reducing the number of EMT and MET type breast cancer stem cells |
| JP6352264B2 (ja) * | 2012-08-13 | 2018-07-04 | ジェネンテック， インコーポレイテッド | 抗ｊａｇｇｅｄ抗体および使用方法 |
| WO2014100435A1 (en) * | 2012-12-19 | 2014-06-26 | Aveo Pharmaceuticals, Inc. | Anti-notch3 antibodies |
| US9944700B2 (en) | 2013-03-13 | 2018-04-17 | Novartis Ag | Notch2 binding molecules for treating respiratory diseases |
| JP2016514130A (ja) * | 2013-03-14 | 2016-05-19 | ノバルティス アーゲー | Ｎｏｔｃｈ３に対する抗体 |
| WO2014172653A2 (en) * | 2013-04-19 | 2014-10-23 | Aveo Pharmaceuticals, Inc. | Anti-notch1 antibodies |
| EP3166627A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Notch pathway inhibition |
| US11142573B2 (en) | 2016-04-29 | 2021-10-12 | Aveo Pharmaceuticals, Inc. | Anti-Notch3 antibody |
| CN111349166B (zh) * | 2018-12-20 | 2022-11-08 | 东莞市朋志生物科技有限公司 | 一种抗人ca72-4糖蛋白的重组抗体 |
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-
2008
- 2008-01-24 CA CA002676008A patent/CA2676008A1/en not_active Abandoned
- 2008-01-24 JP JP2009547285A patent/JP5618544B2/ja not_active Expired - Fee Related
- 2008-01-24 US US12/010,421 patent/US8088617B2/en not_active Expired - Fee Related
- 2008-01-24 AU AU2008209482A patent/AU2008209482B2/en not_active Ceased
- 2008-01-24 EP EP08724737A patent/EP2125887A4/en not_active Withdrawn
- 2008-01-24 WO PCT/US2008/000884 patent/WO2008091641A2/en not_active Ceased
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2011
- 2011-11-30 US US13/308,224 patent/US8460661B2/en not_active Expired - Fee Related
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2013
- 2013-05-09 US US13/890,805 patent/US8921106B2/en not_active Expired - Fee Related
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2014
- 2014-11-21 US US14/550,703 patent/US9617340B2/en not_active Expired - Fee Related
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| US8460661B2 (en) | 2013-06-11 |
| EP2125887A4 (en) | 2010-11-10 |
| WO2008091641A2 (en) | 2008-07-31 |
| US9617340B2 (en) | 2017-04-11 |
| US20120308558A1 (en) | 2012-12-06 |
| WO2008091641A3 (en) | 2008-12-04 |
| EP2125887A2 (en) | 2009-12-02 |
| JP5618544B2 (ja) | 2014-11-05 |
| JP2010517513A (ja) | 2010-05-27 |
| US20150183878A1 (en) | 2015-07-02 |
| US8921106B2 (en) | 2014-12-30 |
| US8088617B2 (en) | 2012-01-03 |
| AU2008209482A1 (en) | 2008-07-31 |
| US20090047285A1 (en) | 2009-02-19 |
| US20130323257A1 (en) | 2013-12-05 |
| AU2008209482B2 (en) | 2014-05-01 |
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