CA2668689C - Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto - Google Patents

Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto Download PDF

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Publication number
CA2668689C
CA2668689C CA2668689A CA2668689A CA2668689C CA 2668689 C CA2668689 C CA 2668689C CA 2668689 A CA2668689 A CA 2668689A CA 2668689 A CA2668689 A CA 2668689A CA 2668689 C CA2668689 C CA 2668689C
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compound
dimethoxy
hexahydro
pyrido
isoquinolin
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CA2668689A1 (en
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Kyle W. Gano
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Neurocrine Biosciences Inc
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Neurocrine Biosciences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2668689A 2006-11-08 2007-11-08 Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto Active CA2668689C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86494406P 2006-11-08 2006-11-08
US60/864,944 2006-11-08
PCT/US2007/084176 WO2008058261A1 (en) 2006-11-08 2007-11-08 Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto

Publications (2)

Publication Number Publication Date
CA2668689A1 CA2668689A1 (en) 2008-05-15
CA2668689C true CA2668689C (en) 2015-12-29

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CA2668689A Active CA2668689C (en) 2006-11-08 2007-11-08 Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto

Country Status (16)

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US (2) US8039627B2 (OSRAM)
EP (1) EP2081929B1 (OSRAM)
JP (1) JP5290185B2 (OSRAM)
KR (1) KR101500766B1 (OSRAM)
CN (1) CN101553487B (OSRAM)
AU (1) AU2007317242B2 (OSRAM)
BR (1) BRPI0718247B1 (OSRAM)
CA (1) CA2668689C (OSRAM)
DK (1) DK2081929T3 (OSRAM)
EA (1) EA018378B1 (OSRAM)
ES (1) ES2402220T3 (OSRAM)
IL (1) IL198250A0 (OSRAM)
MX (1) MX2009004910A (OSRAM)
PL (1) PL2081929T3 (OSRAM)
PT (1) PT2081929E (OSRAM)
WO (1) WO2008058261A1 (OSRAM)

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Also Published As

Publication number Publication date
JP5290185B2 (ja) 2013-09-18
US8039627B2 (en) 2011-10-18
JP2010509366A (ja) 2010-03-25
CN101553487A (zh) 2009-10-07
US8357697B2 (en) 2013-01-22
KR101500766B9 (ko) 2024-09-25
BRPI0718247B1 (pt) 2021-09-21
IL198250A0 (en) 2009-12-24
PL2081929T3 (pl) 2013-06-28
US20120077839A1 (en) 2012-03-29
EP2081929A1 (en) 2009-07-29
EA018378B1 (ru) 2013-07-30
AU2007317242B2 (en) 2013-08-01
EP2081929B1 (en) 2013-01-09
BRPI0718247A2 (pt) 2014-01-07
WO2008058261A1 (en) 2008-05-15
CN101553487B (zh) 2012-06-13
MX2009004910A (es) 2009-07-24
AU2007317242A1 (en) 2008-05-15
KR101500766B1 (ko) 2015-03-16
US20080167337A1 (en) 2008-07-10
KR20090079257A (ko) 2009-07-21
ES2402220T8 (es) 2021-12-23
ES2402220T3 (es) 2013-04-29
DK2081929T3 (da) 2013-04-15
PT2081929E (pt) 2013-04-15
CA2668689A1 (en) 2008-05-15
EA200970461A1 (ru) 2009-12-30

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