PL2081929T3 - Podstawione związki 3-izobutylo-9,10-dimetoksy-1,3,4,6,7,11b-heksahydro-2H-pirydo[2,1-a]izochinolin-2-olowe i ich wytwarzania - Google Patents
Podstawione związki 3-izobutylo-9,10-dimetoksy-1,3,4,6,7,11b-heksahydro-2H-pirydo[2,1-a]izochinolin-2-olowe i ich wytwarzaniaInfo
- Publication number
- PL2081929T3 PL2081929T3 PL07864160T PL07864160T PL2081929T3 PL 2081929 T3 PL2081929 T3 PL 2081929T3 PL 07864160 T PL07864160 T PL 07864160T PL 07864160 T PL07864160 T PL 07864160T PL 2081929 T3 PL2081929 T3 PL 2081929T3
- Authority
- PL
- Poland
- Prior art keywords
- isoquinolin
- pyrido
- hexahydro
- dimethoxy
- isobutyl
- Prior art date
Links
- WEQLWGNDNRARGE-UHFFFAOYSA-N b-Dihydrotetrabenazine Chemical class C1CN2CC(CC(C)C)C(O)CC2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86494406P | 2006-11-08 | 2006-11-08 | |
| PCT/US2007/084176 WO2008058261A1 (en) | 2006-11-08 | 2007-11-08 | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto |
| EP07864160A EP2081929B1 (en) | 2006-11-08 | 2007-11-08 | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2081929T3 true PL2081929T3 (pl) | 2013-06-28 |
Family
ID=39110526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07864160T PL2081929T3 (pl) | 2006-11-08 | 2007-11-08 | Podstawione związki 3-izobutylo-9,10-dimetoksy-1,3,4,6,7,11b-heksahydro-2H-pirydo[2,1-a]izochinolin-2-olowe i ich wytwarzania |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8039627B2 (OSRAM) |
| EP (1) | EP2081929B1 (OSRAM) |
| JP (1) | JP5290185B2 (OSRAM) |
| KR (1) | KR101500766B1 (OSRAM) |
| CN (1) | CN101553487B (OSRAM) |
| AU (1) | AU2007317242B2 (OSRAM) |
| BR (1) | BRPI0718247B1 (OSRAM) |
| CA (1) | CA2668689C (OSRAM) |
| DK (1) | DK2081929T3 (OSRAM) |
| EA (1) | EA018378B1 (OSRAM) |
| ES (1) | ES2402220T3 (OSRAM) |
| IL (1) | IL198250A0 (OSRAM) |
| MX (1) | MX2009004910A (OSRAM) |
| PL (1) | PL2081929T3 (OSRAM) |
| PT (1) | PT2081929E (OSRAM) |
| WO (1) | WO2008058261A1 (OSRAM) |
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|---|---|---|---|---|
| CN101553487B (zh) | 2006-11-08 | 2012-06-13 | 纽罗克里生物科学有限公司 | 取代的3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-吡啶并[2,1-a]异喹啉-2-醇化合物和与其相关的方法 |
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| BR112015017878A2 (pt) | 2013-01-31 | 2017-07-11 | Auspex Pharmaceuticals Inc | composto da fórmula estrutural ii, composto da fórmula estrutural iii, composição farmacêutica e método de tratamento de um distúrbio mediado por vmat2 |
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| US9670210B2 (en) | 2014-02-13 | 2017-06-06 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
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| KR102528845B1 (ko) | 2015-03-06 | 2023-05-08 | 오스펙스 파마슈티칼스, 인코포레이티드 | 비정상적 불수의 운동 장애의 치료 방법 |
| MX373154B (es) | 2015-04-03 | 2020-04-22 | Incyte Holdings Corp | Compuestos heterocíclicos como inhibidores de demetilasa 1 específica de lisina (lsd1). |
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| JP2018530612A (ja) | 2015-10-09 | 2018-10-18 | テバ、ファーマスーティカルズ、インターナショナル、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツングＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｇｍｂｈ | パーキンソン病の治療のための重水素化レボドパとカルビドパおよびオピカポンとの組合せ |
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| JP6869988B2 (ja) * | 2015-12-23 | 2021-05-12 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法 |
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| CN109153676B (zh) * | 2016-06-29 | 2021-08-10 | 苏州科睿思制药有限公司 | Nbi-98854的晶型及其制备方法和用途 |
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| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
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| CN110621674B (zh) | 2017-12-26 | 2022-03-29 | 苏州科睿思制药有限公司 | 一种Valbenazine二对甲苯磺酸盐的晶型及其制备方法和用途 |
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| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
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| US10689380B1 (en) | 2019-07-30 | 2020-06-23 | Farmhispania S.A. | Crystalline forms of valbenazine ditosylate |
| WO2021027792A1 (zh) * | 2019-08-12 | 2021-02-18 | 山东绿叶制药有限公司 | Vmat2抑制剂及其制备方法和应用 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
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| CN110698397A (zh) * | 2019-10-28 | 2020-01-17 | 南京红杉生物科技有限公司 | 丁苯那嗪中间体及其合成方法、应用和合成用中间产物 |
| MX2023010566A (es) | 2021-03-22 | 2023-09-21 | Neurocrine Biosciences Inc | Inhibidores de proteina transportadora vesicular monoaminotransportadora-2 (vmat2) y metodos de uso. |
| WO2022232060A1 (en) | 2021-04-26 | 2022-11-03 | Neurocrine Biosciences, Inc. | Processes for the synthesis of valbenazine |
| US20240342160A1 (en) | 2021-06-30 | 2024-10-17 | Neurocrine Biosciences, Inc. | Valbenazine for use in the treatment of dyskinesia due to cerebral palsy |
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| TW202421131A (zh) | 2022-09-21 | 2024-06-01 | 美商紐羅克里生物科學有限公司 | Vmat2抑制劑及其使用方法 |
| WO2025038959A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| WO2025038938A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Valbenazine for use in the treatment of huntington's chorea |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US2852518A (en) * | 1957-05-23 | 1958-09-16 | Parke Davis & Co | Di-substituted quinoline compounds |
| WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| US6610841B1 (en) | 1997-12-18 | 2003-08-26 | Gilead Sciences, Inc. | Nucleotide-based prodrugs |
| US7045543B2 (en) * | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
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| EP1907017A4 (en) | 2005-06-29 | 2011-05-04 | Univ Columbia | USE OF DTBZ FOR THE PRESENTATION OF ENDOCRINE PANCREAS AND BETAZELL MASS IN DIABETES TYPE 1 |
| GB0514501D0 (en) | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
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| PL1855677T3 (pl) | 2005-08-06 | 2009-07-31 | Biovail Laboratories Int Barbados Srl | 3,11B-Cis-dihydrotetrabenazyny do leczenia schizofrenii i innych psychoz |
| CN101553487B (zh) | 2006-11-08 | 2012-06-13 | 纽罗克里生物科学有限公司 | 取代的3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-吡啶并[2,1-a]异喹啉-2-醇化合物和与其相关的方法 |
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2007
- 2007-11-08 CN CN2007800395790A patent/CN101553487B/zh active Active
- 2007-11-08 KR KR1020097011731A patent/KR101500766B1/ko active Active
- 2007-11-08 EP EP07864160A patent/EP2081929B1/en active Active
- 2007-11-08 US US11/937,445 patent/US8039627B2/en active Active
- 2007-11-08 BR BRPI0718247-3A patent/BRPI0718247B1/pt active IP Right Grant
- 2007-11-08 DK DK07864160.2T patent/DK2081929T3/da active
- 2007-11-08 CA CA2668689A patent/CA2668689C/en active Active
- 2007-11-08 ES ES07864160T patent/ES2402220T3/es active Active
- 2007-11-08 PL PL07864160T patent/PL2081929T3/pl unknown
- 2007-11-08 WO PCT/US2007/084176 patent/WO2008058261A1/en not_active Ceased
- 2007-11-08 EA EA200970461A patent/EA018378B1/ru unknown
- 2007-11-08 JP JP2009536493A patent/JP5290185B2/ja active Active
- 2007-11-08 AU AU2007317242A patent/AU2007317242B2/en active Active
- 2007-11-08 PT PT78641602T patent/PT2081929E/pt unknown
- 2007-11-08 MX MX2009004910A patent/MX2009004910A/es active IP Right Grant
-
2009
- 2009-04-21 IL IL198250A patent/IL198250A0/en active IP Right Grant
-
2011
- 2011-09-20 US US13/237,709 patent/US8357697B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101553487A (zh) | 2009-10-07 |
| AU2007317242A1 (en) | 2008-05-15 |
| BRPI0718247B1 (pt) | 2021-09-21 |
| EA018378B1 (ru) | 2013-07-30 |
| EA200970461A1 (ru) | 2009-12-30 |
| US8039627B2 (en) | 2011-10-18 |
| CA2668689A1 (en) | 2008-05-15 |
| BRPI0718247A2 (pt) | 2014-01-07 |
| ES2402220T3 (es) | 2013-04-29 |
| EP2081929B1 (en) | 2013-01-09 |
| JP5290185B2 (ja) | 2013-09-18 |
| US20080167337A1 (en) | 2008-07-10 |
| CA2668689C (en) | 2015-12-29 |
| ES2402220T8 (es) | 2021-12-23 |
| DK2081929T3 (da) | 2013-04-15 |
| KR101500766B1 (ko) | 2015-03-16 |
| MX2009004910A (es) | 2009-07-24 |
| KR20090079257A (ko) | 2009-07-21 |
| US20120077839A1 (en) | 2012-03-29 |
| CN101553487B (zh) | 2012-06-13 |
| PT2081929E (pt) | 2013-04-15 |
| AU2007317242B2 (en) | 2013-08-01 |
| JP2010509366A (ja) | 2010-03-25 |
| WO2008058261A1 (en) | 2008-05-15 |
| EP2081929A1 (en) | 2009-07-29 |
| KR101500766B9 (ko) | 2024-09-25 |
| US8357697B2 (en) | 2013-01-22 |
| IL198250A0 (en) | 2009-12-24 |
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