CA2667153A1 - Fatty acid alcohols - Google Patents
Fatty acid alcohols Download PDFInfo
- Publication number
- CA2667153A1 CA2667153A1 CA002667153A CA2667153A CA2667153A1 CA 2667153 A1 CA2667153 A1 CA 2667153A1 CA 002667153 A CA002667153 A CA 002667153A CA 2667153 A CA2667153 A CA 2667153A CA 2667153 A1 CA2667153 A1 CA 2667153A1
- Authority
- CA
- Canada
- Prior art keywords
- pro
- omega
- composition according
- lipid composition
- eicosapentaen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000194 fatty acid Substances 0.000 title claims description 33
- -1 Fatty acid alcohols Chemical class 0.000 title claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 title description 25
- 229930195729 fatty acid Natural products 0.000 title description 25
- 239000000203 mixture Substances 0.000 claims abstract description 233
- 150000002632 lipids Chemical class 0.000 claims abstract description 188
- 239000000651 prodrug Substances 0.000 claims abstract description 157
- 229940002612 prodrug Drugs 0.000 claims abstract description 157
- 150000001298 alcohols Chemical class 0.000 claims abstract description 141
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims abstract description 119
- 238000011282 treatment Methods 0.000 claims abstract description 51
- 238000000034 method Methods 0.000 claims abstract description 42
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 206010014486 Elevated triglycerides Diseases 0.000 claims abstract description 8
- LUDPTMYCBZDPEZ-UHFFFAOYSA-N icosa-5,8,11,14,17-pentaen-1-ol Chemical compound CCC=CCC=CCC=CCC=CCC=CCCCCO LUDPTMYCBZDPEZ-UHFFFAOYSA-N 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 45
- 150000003839 salts Chemical class 0.000 claims description 36
- 150000002148 esters Chemical class 0.000 claims description 35
- 238000004519 manufacturing process Methods 0.000 claims description 28
- 230000002265 prevention Effects 0.000 claims description 26
- 235000015872 dietary supplement Nutrition 0.000 claims description 21
- 125000003342 alkenyl group Chemical group 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 16
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 8
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- 229910010084 LiAlH4 Inorganic materials 0.000 claims description 4
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 4
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- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical class B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 claims description 3
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical class C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 3
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- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- 239000004411 aluminium Substances 0.000 claims 2
- 229910052796 boron Inorganic materials 0.000 claims 2
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- 239000003921 oil Substances 0.000 abstract description 17
- 150000004665 fatty acids Chemical class 0.000 description 21
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 20
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- 125000004494 ethyl ester group Chemical group 0.000 description 16
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- 125000005547 pivalate group Chemical group 0.000 description 11
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- 101150041968 CDC13 gene Proteins 0.000 description 8
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- DTMGIJFHGGCSLO-FIAQIACWSA-N ethyl (4z,7z,10z,13z,16z,19z)-docosa-4,7,10,13,16,19-hexaenoate;ethyl (5z,8z,11z,14z,17z)-icosa-5,8,11,14,17-pentaenoate Chemical compound CCOC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC.CCOC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC DTMGIJFHGGCSLO-FIAQIACWSA-N 0.000 description 8
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- 239000004202 carbamide Substances 0.000 description 7
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
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Applications Claiming Priority (9)
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| US60/856,269 | 2006-11-03 | ||
| US60/856,268 | 2006-11-03 | ||
| PCT/IB2007/004590 WO2008139261A2 (en) | 2006-11-03 | 2007-11-02 | Omega-3 lipid compound |
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| WO2009134147A1 (en) * | 2008-05-02 | 2009-11-05 | Pronova Biopharma Norge As | Lipid compositions containing derivatives of epa and dha an their use thereof |
| GB201009368D0 (en) * | 2010-06-04 | 2010-07-21 | Sana Pharma As | Dietary formulations |
| CN103096904B (zh) * | 2010-09-01 | 2016-03-09 | 日本水产株式会社 | 酒精性伤害缓解剂 |
| CA2876177C (en) | 2012-06-11 | 2022-06-14 | The Cleveland Clinic Foundation | Treatment and prevention of cardiovascular disease and thrombosis |
| CN102860506A (zh) * | 2012-08-08 | 2013-01-09 | 辽宁省大连海洋渔业集团公司 | 磷虾油微囊粉及其制备方法 |
| PL2961727T3 (pl) * | 2013-02-28 | 2017-06-30 | Pronova Biopharma Norge As | Sposób wytwarzania kwasu 2-((5Z,8Z, 11Z,14Z,17Z)-ejkoza-5,8,11,14,17-pentaenyloksy)butanowego |
| EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
| CA2958439C (en) | 2014-10-02 | 2022-09-20 | Evonik Industries Ag | Feedstuff of high abrasion resistance and good stability in water, containing pufas |
| ES2873094T3 (es) | 2014-10-02 | 2021-11-03 | Evonik Operations Gmbh | Procedimiento para la producción de un pienso que contiene PUFAs mediante extrusión de una biomasa que contiene PUFAs de tipo Labyrinthulomycetes |
| FI3200604T4 (fi) | 2014-10-02 | 2025-07-29 | Evonik Operations Gmbh | Menetelmä rehun valmistamiseksi |
| ES2870093T3 (es) | 2014-10-02 | 2021-10-26 | Evonik Operations Gmbh | Biomasa que contiene PUFA con estabilidad celular elevada y su empleo para la producción de piensos |
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| JPH01207224A (ja) * | 1988-02-10 | 1989-08-21 | Nonogawa Shoji:Kk | 頭髪用化粧料及び養毛剤 |
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| DK1121928T3 (da) * | 2000-01-31 | 2008-03-17 | Haerting S A | Sammensætninger indeholdende phytosterol- og policosanolestere af fedtsyrer til reduktion af niveauet af blodcholesterol og -triglycerider |
| CN1665566A (zh) * | 2000-09-21 | 2005-09-07 | 营养21公司 | 用铬络合物、共轭脂肪酸和 /或共轭脂肪醇治疗糖尿病、减少身体脂肪、改善胰岛素敏感性、缓解高血糖症和高胆固醇血症的方法和组合物 |
| CN102319266B (zh) * | 2001-06-18 | 2014-12-17 | 海王星技术&生物资源有限公司 | 用于预防和/或治疗心血管疾病、关节炎、皮肤癌、糖尿病、经前综合症和透皮转运的磷虾和/或海产提取物 |
| ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| CN1665496B (zh) * | 2002-05-03 | 2010-05-05 | 派普生物保健品公司 | Epa和dha在制备二级预防神经性疾患的药物中的用途 |
| EP1544281B1 (en) * | 2002-08-07 | 2016-10-05 | Kao Corporation | Fat composition |
| US8017651B2 (en) * | 2002-11-22 | 2011-09-13 | Bionexus, Ltd. | Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia |
| WO2004078166A2 (en) * | 2003-03-05 | 2004-09-16 | Solvay Pharmaceuticals Gmbh | Use of omega-3-fatty acids in the treatment of diabetic patients |
| SE0303513D0 (sv) * | 2003-12-19 | 2003-12-19 | Pronova Biocare As | Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof |
-
2007
- 2007-11-02 BR BRPI0718393-3A patent/BRPI0718393A2/pt not_active IP Right Cessation
- 2007-11-02 JP JP2009535151A patent/JP2010509204A/ja active Pending
- 2007-11-02 CN CN200780040625A patent/CN101646426A/zh active Pending
- 2007-11-02 RU RU2009121007/04A patent/RU2009121007A/ru not_active Application Discontinuation
- 2007-11-02 WO PCT/IB2007/004590 patent/WO2008139261A2/en not_active Ceased
- 2007-11-02 CA CA002667153A patent/CA2667153A1/en not_active Abandoned
- 2007-11-02 KR KR1020097011471A patent/KR20090077081A/ko not_active Ceased
- 2007-11-02 MX MX2009004339A patent/MX2009004339A/es not_active Application Discontinuation
- 2007-11-02 US US12/447,971 patent/US20100266681A1/en not_active Abandoned
-
2009
- 2009-06-02 NO NO20092131A patent/NO20092131L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20092131L (no) | 2009-06-30 |
| BRPI0718393A2 (pt) | 2013-11-26 |
| RU2009121007A (ru) | 2010-12-10 |
| JP2010509204A (ja) | 2010-03-25 |
| US20100266681A1 (en) | 2010-10-21 |
| MX2009004339A (es) | 2009-05-20 |
| WO2008139261A3 (en) | 2009-08-20 |
| KR20090077081A (ko) | 2009-07-14 |
| CN101646426A (zh) | 2010-02-10 |
| WO2008139261A9 (en) | 2009-11-12 |
| WO2008139261A2 (en) | 2008-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20141104 |