CA2657533A1 - Drug delivery polymer with hydrochloride salt of clindamycin - Google Patents
Drug delivery polymer with hydrochloride salt of clindamycin Download PDFInfo
- Publication number
- CA2657533A1 CA2657533A1 CA002657533A CA2657533A CA2657533A1 CA 2657533 A1 CA2657533 A1 CA 2657533A1 CA 002657533 A CA002657533 A CA 002657533A CA 2657533 A CA2657533 A CA 2657533A CA 2657533 A1 CA2657533 A1 CA 2657533A1
- Authority
- CA
- Canada
- Prior art keywords
- insert
- hydrogel matrix
- contacting
- clindamycin
- clindamycin hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 title claims abstract description 97
- 229960002227 clindamycin Drugs 0.000 title claims description 31
- 229920000642 polymer Polymers 0.000 title claims description 31
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title description 3
- 238000012377 drug delivery Methods 0.000 title description 2
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- 239000011159 matrix material Substances 0.000 claims abstract description 86
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- 238000000034 method Methods 0.000 claims abstract description 37
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- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 5
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 5
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- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 description 23
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- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 3
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- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80714906P | 2006-07-12 | 2006-07-12 | |
| US60/807,149 | 2006-07-12 | ||
| PCT/GB2007/002604 WO2008007098A2 (en) | 2006-07-12 | 2007-07-12 | Drug delivery polymer with hydrochloride salt of clindamycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2657533A1 true CA2657533A1 (en) | 2008-01-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002657533A Abandoned CA2657533A1 (en) | 2006-07-12 | 2007-07-12 | Drug delivery polymer with hydrochloride salt of clindamycin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080160065A1 (enExample) |
| EP (1) | EP2037938A2 (enExample) |
| JP (1) | JP2009542788A (enExample) |
| CN (1) | CN101500583B (enExample) |
| AU (1) | AU2007274081B2 (enExample) |
| BR (1) | BRPI0713203A2 (enExample) |
| CA (1) | CA2657533A1 (enExample) |
| MX (1) | MX2009000053A (enExample) |
| RU (1) | RU2444364C2 (enExample) |
| WO (1) | WO2008007098A2 (enExample) |
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| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| EP2244782A4 (en) | 2008-01-25 | 2011-09-14 | Univ Utah Res Found | POLYMER WITH LINEAR ORDER RELEASE |
| CN102335113A (zh) * | 2010-07-20 | 2012-02-01 | 杭州赛利药物研究所有限公司 | 克林霉素磷酸酯阴道缓释凝胶及其制备方法 |
| US9198957B2 (en) * | 2011-01-31 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Treatment and prevention of bacterial vaginosis and Gardnerella vaginalis infections |
| EP3648779A4 (en) * | 2017-07-07 | 2021-03-17 | Osel, Inc. | USING VAGINAL LACTOBACILLI TO IMPROVE THE SUCCESS RATE OF IN VITRO FERTILIZATION |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565991A (en) * | 1968-04-22 | 1971-02-23 | Searle & Co | Methods for use and compositions of 17alpha-ethyl-19-nortestosterone and carriers for the sustained release of steroids |
| US3830907A (en) * | 1968-04-22 | 1974-08-20 | Searle & Co | Compositions for the sustained release of 17alpha-ethyl-19-nortestosterone |
| US3860701A (en) * | 1968-04-22 | 1975-01-14 | Searle & Co | Method for use and compositions of 11-lower alkyl steroids and drug delivery system for the controlled elution of 11-lower alkyl steroids |
| US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3896819A (en) * | 1969-04-01 | 1975-07-29 | Alejandro Zaffaroni | IUD having a replenishing drug reservoir |
| US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3734097A (en) * | 1969-04-01 | 1973-05-22 | Alza Corp | Therapeutic adhesive tape |
| US3967618A (en) * | 1969-04-01 | 1976-07-06 | Alza Corporation | Drug delivery device |
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3948262A (en) * | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3760805A (en) * | 1971-01-13 | 1973-09-25 | Alza Corp | Osmotic dispenser with collapsible supply container |
| US4034756A (en) * | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
| US3941880A (en) * | 1971-02-22 | 1976-03-02 | G. D. Searle & Co. | Method for use of 11-lower alkyl steroids |
| US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US3892842A (en) * | 1971-09-01 | 1975-07-01 | Alza Corp | Intrauterine contraceptive device for releasing steroid having double bond functionality |
| US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3867933A (en) * | 1973-03-06 | 1975-02-25 | Tecna Corp | Intrauterine device and process of making the same |
| US4036227A (en) * | 1973-04-25 | 1977-07-19 | Alza Corporation | Osmotic releasing device having a plurality of release rate patterns |
| FR2250520B1 (enExample) * | 1973-11-09 | 1977-04-15 | Cournut Rene | |
| US4142526A (en) * | 1974-12-23 | 1979-03-06 | Alza Corporation | Osmotic releasing system with means for changing release therefrom |
| US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4286587A (en) * | 1978-10-11 | 1981-09-01 | Alza Corporation | Vaginal drug delivery system made from polymer |
| NZ193221A (en) * | 1979-03-21 | 1984-08-24 | M P Embrey | Controlled release composition |
| US5017382A (en) * | 1979-03-21 | 1991-05-21 | National Research Development Corporation | Controlled release compositions (II) |
| US4250611A (en) * | 1979-04-19 | 1981-02-17 | Alza Corporation | Process for making drug delivery device with reservoir |
| US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
| DE3017989C2 (de) * | 1980-05-10 | 1982-05-19 | IPOS Gesellschaft für integrierte Prothesen-Entwicklung und orthopädietechnischen Service mbH & Co KG, 2120 Lüneburg | "Auffangbeutel für künstliche Darmausgänge" |
| US4694238A (en) * | 1984-01-10 | 1987-09-15 | Peter Norton | Dual voltage power supply system for vehicles |
| US4596576A (en) * | 1984-10-12 | 1986-06-24 | Akzo N.V. | Release system for two or more active substances |
| US5731303A (en) * | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| JP2538953B2 (ja) * | 1987-11-17 | 1996-10-02 | 三菱重工業株式会社 | 工業用ロボットのバランス機構 |
| US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
| US5176907A (en) * | 1991-08-13 | 1993-01-05 | The Johns Hopkins University School Of Medicine | Biocompatible and biodegradable poly (phosphoester-urethanes) |
| JP2909477B2 (ja) * | 1992-07-16 | 1999-06-23 | ビーティージー・インターナショナル・リミテッド | 回収可能なペッサリー |
| DE69332954D1 (de) * | 1992-10-21 | 2003-06-12 | Gynetech Lab Inc | Abgabesystem bestehend aus einem vaginaschwamm |
| US5514698A (en) * | 1994-03-21 | 1996-05-07 | Ortho Pharmaceutical Corporation | Antifungal vaginal cream composition |
| IL116433A (en) * | 1994-12-19 | 2002-02-10 | Galen Chemicals Ltd | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
| US6413536B1 (en) * | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| US7833543B2 (en) * | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US5968542A (en) * | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| US6201065B1 (en) * | 1995-07-28 | 2001-03-13 | Focal, Inc. | Multiblock biodegradable hydrogels for drug delivery and tissue treatment |
| PL186278B1 (pl) * | 1995-12-27 | 2003-12-31 | Janssen Pharmaceutica Nv | Bioadhezyjna kompozycja stała, postać dawkowania,sposób wytwarzania tabletek na sucho i łączne zastosowanie składników |
| US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| US6416779B1 (en) * | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
| US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| US6572874B1 (en) * | 1998-05-15 | 2003-06-03 | Umd, Inc. | Vaginal delivery of bisphosphonates |
| US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| EP1007581A1 (en) * | 1997-08-25 | 2000-06-14 | Union Carbide Chemicals & Plastics Technology Corporation | Biodegradable lactone copolymers |
| DE19737348C2 (de) * | 1997-08-27 | 2002-07-25 | Dan-Gabriel Vulpescu | Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung |
| EP1051437B1 (en) * | 1998-01-28 | 2005-08-17 | Bristol-Myers Squibb Company | Methods of preparing polyurethane adhesives and adhesives produced thereby |
| US6028057A (en) * | 1998-02-19 | 2000-02-22 | Thorn Bioscience, Llc | Regulation of estrus and ovulation in gilts |
| US6013637A (en) * | 1998-06-12 | 2000-01-11 | Dermik Laboratories Inc. | Anti-acne method and composition |
| GB9826192D0 (en) * | 1998-12-01 | 1999-01-20 | Controlled Theraputics Scotlan | Oral transmucosal delivery |
| IT1317735B1 (it) * | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
| US6740333B2 (en) * | 2000-07-07 | 2004-05-25 | Anestic Aps | Suppository and composition comprising at least one polyethylene glycol |
| US6811549B2 (en) * | 2001-02-16 | 2004-11-02 | William H. Fleming | Administration of therapeutic or diagnostic agents using interlabial pad |
| AU2003207961A1 (en) * | 2002-01-16 | 2003-07-30 | Ramot At Tel Aviv University Ltd. | Compositions and their use for enhancing and inhibiting fertilization |
| AU2003208679A1 (en) * | 2002-02-08 | 2003-09-02 | Advanced Animal Technology Limited | Control of a biological function |
| US6861503B2 (en) * | 2002-02-27 | 2005-03-01 | Poly-Med, Inc. | Interlinked solid polyethylene glycols and copolymers thereof |
| US7179481B2 (en) * | 2002-09-19 | 2007-02-20 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| GB0222522D0 (en) * | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| GB0301577D0 (en) * | 2003-01-23 | 2003-02-26 | Edko Pazarlama Tanitim Ltd Sti | Topical pharmaceutical and/or cosmetic dispense systems |
| WO2004091579A1 (en) * | 2003-04-16 | 2004-10-28 | Pharmacia Corporation | Stabilized prostaglandin formulation |
| ATE461681T1 (de) * | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| US8399013B2 (en) * | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| JP2007505927A (ja) * | 2003-09-19 | 2007-03-15 | ドラッグテック コーポレイション | 薬物送達システム |
| DE50300325D1 (de) * | 2003-11-03 | 2005-03-31 | Peter-Hansen Volkmann | Vaginalpflegezusammensetzung |
| EP1555278A1 (en) * | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Biodegradable multi-block co-polymers |
| CN100449137C (zh) * | 2004-01-28 | 2009-01-07 | 新冷凝器公司 | 从曲轴箱废气清除污染物的设备 |
| US20070166382A1 (en) * | 2004-03-26 | 2007-07-19 | Kiser Patrick F | Bioresponsive polymer system for delivery of microbicides |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| KR101229701B1 (ko) * | 2004-07-09 | 2013-02-05 | 라보라토이레 에이치알에이 파르마 | 프로게스테론 수용체 조절제를 함유하는 서방형 조성물 |
| GB0417401D0 (en) * | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| US20060078616A1 (en) * | 2004-08-30 | 2006-04-13 | Georgewill Dawaye A | Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
| US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
| WO2006084082A1 (en) * | 2005-02-03 | 2006-08-10 | Duramed Pharmaceuticals, Inc. | Compositions of unconjugated estrogens and methods for their use |
| TW200744610A (en) * | 2005-06-21 | 2007-12-16 | Organon Nv | New regimens for controlled drug delivery devices for contraception |
| TW200727920A (en) * | 2005-06-21 | 2007-08-01 | Organon Nv | New regimens for oral monophasic contraceptives |
| AU2006321915B2 (en) * | 2005-12-06 | 2012-04-26 | Covidien Lp | Bioabsorbable surgical composition |
| EP1960447A4 (en) * | 2005-12-08 | 2010-12-01 | Tyco Healthcare | BIOCOMPATIBLE SURGICAL COMPOSITIONS |
| US20070148105A1 (en) * | 2005-12-22 | 2007-06-28 | Donald Spector | Compositions and methods comprising magnetic particles for health use |
| US8047980B2 (en) * | 2006-07-10 | 2011-11-01 | Mcneil-Ppc, Inc. | Method of treating urinary incontinence |
| WO2008062009A1 (en) * | 2006-11-22 | 2008-05-29 | N.V. Organon | Delivery system for risperidone |
| SG195525A1 (en) * | 2007-06-26 | 2013-12-30 | Warner Chilcott Co Llc | Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs |
| US20110059040A1 (en) * | 2007-06-27 | 2011-03-10 | Kiser Patrick F | Compositions and methods for inhibiting viral and bacterial activity |
| US8741329B2 (en) * | 2007-09-21 | 2014-06-03 | Merck Sharp & Dohme B.V. | Drug delivery system |
| EP2244782A4 (en) * | 2008-01-25 | 2011-09-14 | Univ Utah Res Found | POLYMER WITH LINEAR ORDER RELEASE |
| FI20085277A0 (fi) * | 2008-04-02 | 2008-04-02 | Bayer Schering Pharma Oy | Kohdunsisäinen järjestelmä |
| US20110150955A1 (en) * | 2009-12-23 | 2011-06-23 | Shannon Elizabeth Klingman | Products and Methods for Reducing Malodor from the Pudendum |
-
2007
- 2007-07-12 US US11/777,175 patent/US20080160065A1/en not_active Abandoned
- 2007-07-12 MX MX2009000053A patent/MX2009000053A/es active IP Right Grant
- 2007-07-12 EP EP07789017A patent/EP2037938A2/en not_active Withdrawn
- 2007-07-12 RU RU2009104695/15A patent/RU2444364C2/ru not_active IP Right Cessation
- 2007-07-12 BR BRPI0713203-4A patent/BRPI0713203A2/pt not_active IP Right Cessation
- 2007-07-12 AU AU2007274081A patent/AU2007274081B2/en not_active Ceased
- 2007-07-12 CN CN200780029743XA patent/CN101500583B/zh not_active Expired - Fee Related
- 2007-07-12 CA CA002657533A patent/CA2657533A1/en not_active Abandoned
- 2007-07-12 WO PCT/GB2007/002604 patent/WO2008007098A2/en not_active Ceased
- 2007-07-12 JP JP2009518960A patent/JP2009542788A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1137646A1 (en) | 2010-08-06 |
| WO2008007098A3 (en) | 2008-03-27 |
| JP2009542788A (ja) | 2009-12-03 |
| CN101500583B (zh) | 2012-05-23 |
| AU2007274081B2 (en) | 2012-08-02 |
| RU2009104695A (ru) | 2010-08-20 |
| EP2037938A2 (en) | 2009-03-25 |
| RU2444364C2 (ru) | 2012-03-10 |
| CN101500583A (zh) | 2009-08-05 |
| WO2008007098A2 (en) | 2008-01-17 |
| BRPI0713203A2 (pt) | 2012-04-03 |
| US20080160065A1 (en) | 2008-07-03 |
| MX2009000053A (es) | 2009-02-23 |
| AU2007274081A1 (en) | 2008-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140527 |
|
| FZDE | Discontinued |
Effective date: 20140527 |