CA2656823C - Cyanocobalamin low viscosity aqueous formulations for intranasal delivery - Google Patents
Cyanocobalamin low viscosity aqueous formulations for intranasal delivery Download PDFInfo
- Publication number
- CA2656823C CA2656823C CA2656823A CA2656823A CA2656823C CA 2656823 C CA2656823 C CA 2656823C CA 2656823 A CA2656823 A CA 2656823A CA 2656823 A CA2656823 A CA 2656823A CA 2656823 C CA2656823 C CA 2656823C
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- Prior art keywords
- cyanocobalamin
- solution
- concentration
- spray
- droplets
- Prior art date
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- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims abstract 5
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- 229940033663 thimerosal Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2863377A CA2863377C (en) | 2006-06-23 | 2006-06-23 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2006/024685 WO2007149098A1 (en) | 2006-06-23 | 2006-06-23 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2863377A Division CA2863377C (en) | 2006-06-23 | 2006-06-23 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2656823A1 CA2656823A1 (en) | 2007-12-27 |
| CA2656823C true CA2656823C (en) | 2015-02-03 |
Family
ID=38833714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2656823A Expired - Fee Related CA2656823C (en) | 2006-06-23 | 2006-06-23 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2035441A4 (de) |
| JP (1) | JP5769924B2 (de) |
| KR (3) | KR20090074722A (de) |
| CN (1) | CN101600729A (de) |
| AU (1) | AU2006344733B2 (de) |
| CA (1) | CA2656823C (de) |
| IL (2) | IL196038A (de) |
| NO (1) | NO20090368L (de) |
| WO (1) | WO2007149098A1 (de) |
| ZA (1) | ZA200900191B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2686299T3 (es) * | 2010-10-29 | 2018-10-17 | Troikaa Pharmaceuticals Ltd | Composiciones nasales de vitamina B12 |
| EP3589269B1 (de) * | 2017-03-02 | 2021-04-07 | Dutch Renewable Energy B.V. | Intranasale verabreichung von physiologisch aktiven stoffen |
| US20220111162A1 (en) * | 2020-07-29 | 2022-04-14 | Lido Ventures Llc | Apparatus, system, and method for facilitating intranasal treatment of a patient |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0218679B1 (de) * | 1985-04-16 | 1991-12-11 | Nastech Pharmaceutical Company, Inc. | Aerosolmittel zur nasenverstäubung von vitamin b 12 |
| US4724231A (en) * | 1985-04-16 | 1988-02-09 | Nastech Pharmaceutical, Inc. | Nasel compositions containing vitamin B12 |
| US5112804A (en) * | 1987-04-01 | 1992-05-12 | Temple University Of The Commonwealth System Of Higher Education | Pharmaceutical composition and method of intranasal administration |
| US4959176A (en) * | 1988-04-29 | 1990-09-25 | Beckman Instruments, Inc. | High resolution non corrosive amino acid analysis buffer solutions |
| US5227311A (en) * | 1988-10-11 | 1993-07-13 | Abbott Laboratories | Intrinsic factor to determine B12 |
| BE1007839A6 (nl) * | 1993-12-20 | 1995-10-31 | Merkus Franciscus W H M Prof | Farmaceutische compositie voor de nasale toediening van hydroxocobalamine. |
| US6406730B1 (en) * | 1998-12-01 | 2002-06-18 | Carl E. Banyard | Process for producing low acid food products |
| FR2787029A1 (fr) * | 1998-12-09 | 2000-06-16 | Biovector Therapeutics | Utilisation dans une composition pharmaceutique pour l'administration par voie nasale de vitamine b12 pour la delivrance d'agents actifs au systeme nerveux central |
| US20040043043A1 (en) * | 2000-09-20 | 2004-03-04 | Schlyter Jimmy Hirschsprung | Preparation of emulsions and concentrates thereof |
| US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
| US6911434B2 (en) * | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| US20040109826A1 (en) * | 2002-12-06 | 2004-06-10 | Dey, L.P. | Stabilized albuterol compositions and method of preparation thereof |
| DE10300719A1 (de) * | 2003-01-11 | 2004-07-22 | Basf Ag | Verbessertes Verfahren zur Herstellung von Vitamin B12 |
| US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
| US20060046969A1 (en) * | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Antibacterial compositions for drug administration |
| JP2009504767A (ja) * | 2005-08-17 | 2009-02-05 | フレミング・アンド・カンパニー・ファーマシューティカルズ | ビタミンｂ１２鼻用スプレーおよび使用方法 |
-
2006
- 2006-06-23 KR KR1020097001414A patent/KR20090074722A/ko not_active Application Discontinuation
- 2006-06-23 CA CA2656823A patent/CA2656823C/en not_active Expired - Fee Related
- 2006-06-23 KR KR1020147021098A patent/KR20140101010A/ko not_active Application Discontinuation
- 2006-06-23 WO PCT/US2006/024685 patent/WO2007149098A1/en active Application Filing
- 2006-06-23 JP JP2009516468A patent/JP5769924B2/ja not_active Expired - Fee Related
- 2006-06-23 KR KR1020177023153A patent/KR20170098977A/ko not_active Application Discontinuation
- 2006-06-23 AU AU2006344733A patent/AU2006344733B2/en not_active Ceased
- 2006-06-23 CN CNA2006800556586A patent/CN101600729A/zh active Pending
- 2006-06-23 EP EP06785533A patent/EP2035441A4/de not_active Ceased
-
2008
- 2008-12-18 IL IL196038A patent/IL196038A/en active IP Right Grant
-
2009
- 2009-01-09 ZA ZA2009/00191A patent/ZA200900191B/en unknown
- 2009-01-23 NO NO20090368A patent/NO20090368L/no not_active Application Discontinuation
-
2016
- 2016-10-21 IL IL248447A patent/IL248447B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL248447A0 (en) | 2016-11-30 |
| IL248447B (en) | 2021-10-31 |
| CA2656823A1 (en) | 2007-12-27 |
| IL196038A (en) | 2016-10-31 |
| KR20090074722A (ko) | 2009-07-07 |
| JP5769924B2 (ja) | 2015-08-26 |
| NO20090368L (no) | 2009-03-23 |
| KR20170098977A (ko) | 2017-08-30 |
| JP2009541312A (ja) | 2009-11-26 |
| EP2035441A1 (de) | 2009-03-18 |
| AU2006344733B2 (en) | 2014-02-27 |
| KR20140101010A (ko) | 2014-08-18 |
| EP2035441A4 (de) | 2013-01-16 |
| IL196038A0 (en) | 2009-09-01 |
| WO2007149098A1 (en) | 2007-12-27 |
| ZA200900191B (en) | 2012-09-26 |
| CN101600729A (zh) | 2009-12-09 |
| AU2006344733A1 (en) | 2007-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20220623 |