NO20090368L - Cyanocobalamin lav viskositets vandige formuleringer for intranasal avlevering - Google Patents
Cyanocobalamin lav viskositets vandige formuleringer for intranasal avleveringInfo
- Publication number
- NO20090368L NO20090368L NO20090368A NO20090368A NO20090368L NO 20090368 L NO20090368 L NO 20090368L NO 20090368 A NO20090368 A NO 20090368A NO 20090368 A NO20090368 A NO 20090368A NO 20090368 L NO20090368 L NO 20090368L
- Authority
- NO
- Norway
- Prior art keywords
- cyanocobalamin
- solution
- csf
- low viscosity
- aqueous formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
En stabil farmasøytisk vannholdig løsning av cyanokobalamin omfattende cyanokobalamin og vann hvor nevnte løsning av cyanokobalamin er egnet for intranasal administrasjon, har en viskositet mindre enn omkring 1000 cPs, og gir en biotilgjengelighet av cyanokobalamin når administrert intranasalt på minst omkring 5% relativ til en intramuskulær injeksjon av cyanokobalamin. Den foreliggende oppfinnelsen er også rettet mot en fremgangsmåte for å heve vitamin B12 nivåene i den cerebrale spinalvæsken (CSF) omfattende å administrere intranasalt en tilstrekkelig mengde av en cyanokobalamin løsning for å øke det gjennomsnittlige forholdet av vitamin Bl2 i CSF i forhold til det i blodserumet (Bl2 CSF/B12 serum x 100) til minst omkring 1,1, omfattende intranasalt å administrere en vannholdig løsning av cyanokobalamin, hvor nevnte løsning av cyanokobalamin har en biotilgjengelighet på minst 5% relativ til en intramuskulær injeksjon av et cyanokobalamin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2006/024685 WO2007149098A1 (en) | 2006-06-23 | 2006-06-23 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090368L true NO20090368L (no) | 2009-03-23 |
Family
ID=38833714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090368A NO20090368L (no) | 2006-06-23 | 2009-01-23 | Cyanocobalamin lav viskositets vandige formuleringer for intranasal avlevering |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2035441A4 (no) |
JP (1) | JP5769924B2 (no) |
KR (3) | KR20140101010A (no) |
CN (1) | CN101600729A (no) |
AU (1) | AU2006344733B2 (no) |
CA (1) | CA2656823C (no) |
IL (2) | IL196038A (no) |
NO (1) | NO20090368L (no) |
WO (1) | WO2007149098A1 (no) |
ZA (1) | ZA200900191B (no) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU24142B1 (es) * | 2010-10-29 | 2015-12-23 | Troikaa Pharmaceuticals Ltd | Composiciones nasales de vitamina b12 |
IL269069B (en) * | 2017-03-02 | 2022-09-01 | Dutch Renewable Energy B V | Intranasal administration of physiologically active substances |
WO2022026762A1 (en) * | 2020-07-29 | 2022-02-03 | Lido Ventures Llc | Apparatus, system, and method for facilitating intranasal treatment of a patient |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4724231A (en) * | 1985-04-16 | 1988-02-09 | Nastech Pharmaceutical, Inc. | Nasel compositions containing vitamin B12 |
JPS62500788A (ja) * | 1985-04-16 | 1987-04-02 | ナステツク フア−マス−テイカル カンパニ− インコ−ポレイテツド | ビタミンb↓1↓2の経鼻噴霧用エアロゾ−ル組成物 |
US5112804A (en) * | 1987-04-01 | 1992-05-12 | Temple University Of The Commonwealth System Of Higher Education | Pharmaceutical composition and method of intranasal administration |
US4959176A (en) * | 1988-04-29 | 1990-09-25 | Beckman Instruments, Inc. | High resolution non corrosive amino acid analysis buffer solutions |
US5227311A (en) * | 1988-10-11 | 1993-07-13 | Abbott Laboratories | Intrinsic factor to determine B12 |
BE1007839A6 (nl) * | 1993-12-20 | 1995-10-31 | Merkus Franciscus W H M Prof | Farmaceutische compositie voor de nasale toediening van hydroxocobalamine. |
US6406730B1 (en) * | 1998-12-01 | 2002-06-18 | Carl E. Banyard | Process for producing low acid food products |
FR2787029A1 (fr) * | 1998-12-09 | 2000-06-16 | Biovector Therapeutics | Utilisation dans une composition pharmaceutique pour l'administration par voie nasale de vitamine b12 pour la delivrance d'agents actifs au systeme nerveux central |
DE60131862D1 (de) * | 2000-09-20 | 2008-01-24 | Nycomed Pharma As | Herstellung von vitaminemulsionen und konzentrate davon |
US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
US6911434B2 (en) * | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
US20040109826A1 (en) * | 2002-12-06 | 2004-06-10 | Dey, L.P. | Stabilized albuterol compositions and method of preparation thereof |
DE10300719A1 (de) * | 2003-01-11 | 2004-07-22 | Basf Ag | Verbessertes Verfahren zur Herstellung von Vitamin B12 |
US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
US20060046969A1 (en) * | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Antibacterial compositions for drug administration |
US20070111964A1 (en) * | 2005-08-17 | 2007-05-17 | Fleming And Company, Pharmaceuticals | Vitamin B12 nasal spray and method of use |
-
2006
- 2006-06-23 KR KR1020147021098A patent/KR20140101010A/ko not_active Application Discontinuation
- 2006-06-23 AU AU2006344733A patent/AU2006344733B2/en not_active Ceased
- 2006-06-23 WO PCT/US2006/024685 patent/WO2007149098A1/en active Application Filing
- 2006-06-23 CN CNA2006800556586A patent/CN101600729A/zh active Pending
- 2006-06-23 KR KR1020177023153A patent/KR20170098977A/ko not_active Application Discontinuation
- 2006-06-23 JP JP2009516468A patent/JP5769924B2/ja not_active Expired - Fee Related
- 2006-06-23 CA CA2656823A patent/CA2656823C/en not_active Expired - Fee Related
- 2006-06-23 EP EP06785533A patent/EP2035441A4/en not_active Ceased
- 2006-06-23 KR KR1020097001414A patent/KR20090074722A/ko not_active Application Discontinuation
-
2008
- 2008-12-18 IL IL196038A patent/IL196038A/en active IP Right Grant
-
2009
- 2009-01-09 ZA ZA2009/00191A patent/ZA200900191B/en unknown
- 2009-01-23 NO NO20090368A patent/NO20090368L/no not_active Application Discontinuation
-
2016
- 2016-10-21 IL IL248447A patent/IL248447B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2006344733B2 (en) | 2014-02-27 |
IL196038A (en) | 2016-10-31 |
CA2656823A1 (en) | 2007-12-27 |
ZA200900191B (en) | 2012-09-26 |
KR20140101010A (ko) | 2014-08-18 |
KR20170098977A (ko) | 2017-08-30 |
EP2035441A4 (en) | 2013-01-16 |
WO2007149098A1 (en) | 2007-12-27 |
IL196038A0 (en) | 2009-09-01 |
IL248447B (en) | 2021-10-31 |
AU2006344733A1 (en) | 2007-12-27 |
JP2009541312A (ja) | 2009-11-26 |
JP5769924B2 (ja) | 2015-08-26 |
CA2656823C (en) | 2015-02-03 |
KR20090074722A (ko) | 2009-07-07 |
IL248447A0 (en) | 2016-11-30 |
EP2035441A1 (en) | 2009-03-18 |
CN101600729A (zh) | 2009-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: ENDO PHARMACEUTICALS INC, US |
|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |