EP2035441A4 - AQUEOUS FORMULATIONS WITH LOW VISCOSITY OF CYANOCOBALAMINE FOR INTRA-NASAL ADMINISTRATION - Google Patents

AQUEOUS FORMULATIONS WITH LOW VISCOSITY OF CYANOCOBALAMINE FOR INTRA-NASAL ADMINISTRATION

Info

Publication number
EP2035441A4
EP2035441A4 EP06785533A EP06785533A EP2035441A4 EP 2035441 A4 EP2035441 A4 EP 2035441A4 EP 06785533 A EP06785533 A EP 06785533A EP 06785533 A EP06785533 A EP 06785533A EP 2035441 A4 EP2035441 A4 EP 2035441A4
Authority
EP
European Patent Office
Prior art keywords
cyanocobalamin
low viscosity
aqueous formulations
intranasal delivery
viscosity aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP06785533A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2035441A1 (en
Inventor
Steven C Quay
Zenaida O Go
Peter C Aprile
Antony P Sileno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Par Pharmaceuticals Inc
Original Assignee
Par Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Par Pharmaceuticals Inc filed Critical Par Pharmaceuticals Inc
Publication of EP2035441A1 publication Critical patent/EP2035441A1/en
Publication of EP2035441A4 publication Critical patent/EP2035441A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP06785533A 2006-06-23 2006-06-23 AQUEOUS FORMULATIONS WITH LOW VISCOSITY OF CYANOCOBALAMINE FOR INTRA-NASAL ADMINISTRATION Ceased EP2035441A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/024685 WO2007149098A1 (en) 2006-06-23 2006-06-23 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery

Publications (2)

Publication Number Publication Date
EP2035441A1 EP2035441A1 (en) 2009-03-18
EP2035441A4 true EP2035441A4 (en) 2013-01-16

Family

ID=38833714

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06785533A Ceased EP2035441A4 (en) 2006-06-23 2006-06-23 AQUEOUS FORMULATIONS WITH LOW VISCOSITY OF CYANOCOBALAMINE FOR INTRA-NASAL ADMINISTRATION

Country Status (10)

Country Link
EP (1) EP2035441A4 (no)
JP (1) JP5769924B2 (no)
KR (3) KR20090074722A (no)
CN (1) CN101600729A (no)
AU (1) AU2006344733B2 (no)
CA (1) CA2656823C (no)
IL (2) IL196038A (no)
NO (1) NO20090368L (no)
WO (1) WO2007149098A1 (no)
ZA (1) ZA200900191B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2686299T3 (es) * 2010-10-29 2018-10-17 Troikaa Pharmaceuticals Ltd Composiciones nasales de vitamina B12
EP3589269B1 (en) * 2017-03-02 2021-04-07 Dutch Renewable Energy B.V. Intranasal administration of physiologically active substances
US20220111162A1 (en) * 2020-07-29 2022-04-14 Lido Ventures Llc Apparatus, system, and method for facilitating intranasal treatment of a patient

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005987A1 (en) * 1985-04-16 1986-10-23 Nastech Pharmaceutical Company, Inc. Aerosol compositions for nasal delivery of vitamin b12
US5112804A (en) * 1987-04-01 1992-05-12 Temple University Of The Commonwealth System Of Higher Education Pharmaceutical composition and method of intranasal administration
WO1995017164A1 (en) * 1993-12-20 1995-06-29 Merkus Franciscus W H M A pharmaceutical composition for the intranasal administration of hydroxocobalamin
WO2000033810A1 (fr) * 1998-12-09 2000-06-15 Biovector Therapeutics (S.A.) Utilisation de vitamine b12 dans une composition nasale pour la delivrance d'agents actifs au systeme nerveux central
WO2007022345A2 (en) * 2005-08-17 2007-02-22 Fleming And Company, Pharmaceuticals Vitamin b12 nasal spray and method of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724231A (en) * 1985-04-16 1988-02-09 Nastech Pharmaceutical, Inc. Nasel compositions containing vitamin B12
US4959176A (en) * 1988-04-29 1990-09-25 Beckman Instruments, Inc. High resolution non corrosive amino acid analysis buffer solutions
US5227311A (en) * 1988-10-11 1993-07-13 Abbott Laboratories Intrinsic factor to determine B12
US6406730B1 (en) * 1998-12-01 2002-06-18 Carl E. Banyard Process for producing low acid food products
US20040043043A1 (en) * 2000-09-20 2004-03-04 Schlyter Jimmy Hirschsprung Preparation of emulsions and concentrates thereof
US20060074034A1 (en) * 2001-09-17 2006-04-06 Collins Douglas A Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
US6911434B2 (en) * 2002-02-04 2005-06-28 Corixa Corporation Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
DE10300719A1 (de) * 2003-01-11 2004-07-22 Basf Ag Verbessertes Verfahren zur Herstellung von Vitamin B12
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
US20060046969A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Antibacterial compositions for drug administration

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005987A1 (en) * 1985-04-16 1986-10-23 Nastech Pharmaceutical Company, Inc. Aerosol compositions for nasal delivery of vitamin b12
US5112804A (en) * 1987-04-01 1992-05-12 Temple University Of The Commonwealth System Of Higher Education Pharmaceutical composition and method of intranasal administration
WO1995017164A1 (en) * 1993-12-20 1995-06-29 Merkus Franciscus W H M A pharmaceutical composition for the intranasal administration of hydroxocobalamin
WO2000033810A1 (fr) * 1998-12-09 2000-06-15 Biovector Therapeutics (S.A.) Utilisation de vitamine b12 dans une composition nasale pour la delivrance d'agents actifs au systeme nerveux central
WO2007022345A2 (en) * 2005-08-17 2007-02-22 Fleming And Company, Pharmaceuticals Vitamin b12 nasal spray and method of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2007149098A1 *

Also Published As

Publication number Publication date
IL248447A0 (en) 2016-11-30
IL248447B (en) 2021-10-31
CA2656823A1 (en) 2007-12-27
IL196038A (en) 2016-10-31
KR20090074722A (ko) 2009-07-07
JP5769924B2 (ja) 2015-08-26
NO20090368L (no) 2009-03-23
KR20170098977A (ko) 2017-08-30
JP2009541312A (ja) 2009-11-26
CA2656823C (en) 2015-02-03
EP2035441A1 (en) 2009-03-18
AU2006344733B2 (en) 2014-02-27
KR20140101010A (ko) 2014-08-18
IL196038A0 (en) 2009-09-01
WO2007149098A1 (en) 2007-12-27
ZA200900191B (en) 2012-09-26
CN101600729A (zh) 2009-12-09
AU2006344733A1 (en) 2007-12-27

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Inventor name: SILENO, ANTONY, P.

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Inventor name: GO, ZENAIDA, O.

Inventor name: QUAY, STEVEN, C.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

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