CA2652648C - Dihydrodiazepines useful as inhibitors of protein kinases - Google Patents
Dihydrodiazepines useful as inhibitors of protein kinases Download PDFInfo
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- CA2652648C CA2652648C CA2652648A CA2652648A CA2652648C CA 2652648 C CA2652648 C CA 2652648C CA 2652648 A CA2652648 A CA 2652648A CA 2652648 A CA2652648 A CA 2652648A CA 2652648 C CA2652648 C CA 2652648C
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Landscapes
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Applications Claiming Priority (9)
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| US87620606P | 2006-12-21 | 2006-12-21 | |
| US60/876,206 | 2006-12-21 | ||
| PCT/US2007/003699 WO2007095188A2 (en) | 2006-02-14 | 2007-02-13 | Dihydrodiazepines useful as inhibitors of protein kinases |
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| CA2652648A1 CA2652648A1 (en) | 2007-08-23 |
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| PT2139892E (pt) * | 2007-03-22 | 2011-11-21 | Takeda Pharmaceutical | Pirimidodiazepinas substituídas úteis como inibidores da plk1 |
| TW200914457A (en) * | 2007-05-31 | 2009-04-01 | Kyowa Hakko Kogyo Kk | Pyrimidodiazepinone derivative |
| HRP20161536T1 (hr) | 2007-06-15 | 2016-12-30 | Msd K.K. | Derivat bicikloanilina |
| EP2190849B1 (en) * | 2007-08-15 | 2013-11-20 | Vertex Pharmceuticals Incorporated | 4-(9-(3,3-difluorocyclopentyl)-5,7,7-trimethyl-6-oxo-6,7,8,9-tetrahydro-5h-pyrimido[4,5-b[1,4]diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases |
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| EP2610256B1 (en) * | 2007-09-28 | 2016-04-27 | Cyclacel Limited | Pyrimidine derivatives as protein kinase inhibitors |
| US20090291938A1 (en) * | 2007-11-19 | 2009-11-26 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| US8598172B2 (en) | 2007-12-04 | 2013-12-03 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
| EP2303889A1 (en) | 2008-06-18 | 2011-04-06 | F. Hoffmann-La Roche AG | Halo-substituted pyrimidodiazepines as plkl inhibitors |
| EP2356122B1 (en) | 2008-06-23 | 2019-03-20 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| AU2009271663B2 (en) | 2008-06-23 | 2014-04-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| EA026557B1 (ru) | 2008-12-09 | 2017-04-28 | Джилид Сайэнс, Инк. | Промежуточные соединения для получения модуляторов толл-подобных рецепторов |
| EP2379559B1 (en) | 2009-01-06 | 2017-10-25 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders |
| WO2010114902A1 (en) * | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted tetrahydropyrazolo-pyrido-azepin compounds |
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| NZ599342A (en) * | 2009-09-25 | 2014-04-30 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| AU2010299579A1 (en) | 2009-09-25 | 2012-05-03 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| WO2011123678A2 (en) | 2010-03-31 | 2011-10-06 | Arqule, Inc. | Substituted benzo-pyrido-triazolo-diazepine compounds |
| CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| WO2011143660A2 (en) | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| EP2902030B1 (en) | 2010-05-14 | 2016-09-14 | Dana-Farber Cancer Institute, Inc. | Thienotriazolodiazepine compounds for treating neoplasia |
| US8933070B2 (en) | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| WO2014159392A1 (en) | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
| JP6553589B2 (ja) | 2013-03-15 | 2019-07-31 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | ピリミド−ジアゼピノン化合物および障害の治療方法 |
| CA2918910A1 (en) | 2013-07-25 | 2015-01-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
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| JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体の使用 |
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| JPS5638032B2 (enExample) | 1972-08-31 | 1981-09-03 | ||
| US3880855A (en) * | 1973-04-16 | 1975-04-29 | Bristol Myers Co | 5,6-DIHYDRO-11-H-pyrimido{8 4,5-b{9 {8 1,4{9 benzodiazepines |
| US3872122A (en) * | 1973-04-16 | 1975-03-18 | Bristol Myers Co | 11 H-Pyrimido{8 4,5-b{9 {8 1,4{9 benzodiazepines |
| JPS51110202A (en) | 1975-03-24 | 1976-09-29 | Susumu Nojima | Denwakyono hyojisochi |
| GB8927872D0 (en) | 1989-12-08 | 1990-02-14 | Beecham Group Plc | Pharmaceuticals |
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2007
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- 2007-02-13 US US11/706,070 patent/US7622463B2/en active Active
- 2007-02-13 TW TW096105339A patent/TW200804389A/zh unknown
- 2007-02-13 AU AU2007215221A patent/AU2007215221C1/en not_active Ceased
- 2007-02-13 DE DE602007008837T patent/DE602007008837D1/de active Active
- 2007-02-13 NZ NZ570530A patent/NZ570530A/en unknown
- 2007-02-13 RU RU2008136854/04A patent/RU2475488C2/ru not_active IP Right Cessation
- 2007-02-13 CA CA2652648A patent/CA2652648C/en active Active
- 2007-02-13 JP JP2008555299A patent/JP5243970B2/ja active Active
- 2007-02-13 EP EP07750530A patent/EP1983987B1/en active Active
- 2007-02-14 AR ARP070100633A patent/AR059505A1/es unknown
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2008
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2009
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2011
- 2011-08-10 US US13/206,638 patent/US8394952B2/en active Active
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2013
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- 2013-01-23 JP JP2013009857A patent/JP2013067666A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
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| JP5243970B2 (ja) | 2013-07-24 |
| EP1983987B1 (en) | 2010-09-01 |
| US20120149898A1 (en) | 2012-06-14 |
| US7622463B2 (en) | 2009-11-24 |
| US20140038935A1 (en) | 2014-02-06 |
| RU2008136854A (ru) | 2010-03-20 |
| AU2007215221C1 (en) | 2013-05-30 |
| TW200804389A (en) | 2008-01-16 |
| US20080167289A1 (en) | 2008-07-10 |
| AU2007215221A1 (en) | 2007-08-23 |
| JP2013067666A (ja) | 2013-04-18 |
| ATE479434T1 (de) | 2010-09-15 |
| WO2007095188A2 (en) | 2007-08-23 |
| NZ570530A (en) | 2011-09-30 |
| RU2475488C2 (ru) | 2013-02-20 |
| NO20083918L (no) | 2008-11-12 |
| US8022202B2 (en) | 2011-09-20 |
| HK1129298A1 (en) | 2009-11-27 |
| DE602007008837D1 (de) | 2010-10-14 |
| JP2009526849A (ja) | 2009-07-23 |
| WO2007095188A3 (en) | 2007-10-25 |
| EP1983987A2 (en) | 2008-10-29 |
| US8394952B2 (en) | 2013-03-12 |
| US20100190765A1 (en) | 2010-07-29 |
| CA2652648A1 (en) | 2007-08-23 |
| IL193240A0 (en) | 2009-08-03 |
| AU2007215221B2 (en) | 2013-01-17 |
| AR059505A1 (es) | 2008-04-09 |
| KR20080095902A (ko) | 2008-10-29 |
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