CA2646230A1 - Chewing gum compositions providing rapid release of nicotine - Google Patents
Chewing gum compositions providing rapid release of nicotine Download PDFInfo
- Publication number
- CA2646230A1 CA2646230A1 CA002646230A CA2646230A CA2646230A1 CA 2646230 A1 CA2646230 A1 CA 2646230A1 CA 002646230 A CA002646230 A CA 002646230A CA 2646230 A CA2646230 A CA 2646230A CA 2646230 A1 CA2646230 A1 CA 2646230A1
- Authority
- CA
- Canada
- Prior art keywords
- nicotine
- use according
- chewing gum
- cellulose
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 244
- 229960002715 nicotine Drugs 0.000 title claims abstract description 224
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 223
- 239000000203 mixture Substances 0.000 title claims abstract description 196
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 120
- 229940112822 chewing gum Drugs 0.000 title claims abstract description 104
- 229920002678 cellulose Polymers 0.000 claims abstract description 63
- 239000001913 cellulose Substances 0.000 claims abstract description 57
- 238000007907 direct compression Methods 0.000 claims abstract description 32
- 230000001055 chewing effect Effects 0.000 claims abstract description 17
- 230000000694 effects Effects 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 230000000977 initiatory effect Effects 0.000 claims abstract description 4
- 239000002585 base Substances 0.000 claims description 54
- 235000010980 cellulose Nutrition 0.000 claims description 38
- 239000000843 powder Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 26
- 229940087730 nicorette Drugs 0.000 claims description 24
- 238000000338 in vitro Methods 0.000 claims description 23
- 239000000796 flavoring agent Substances 0.000 claims description 22
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 19
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 19
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 19
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 19
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- -1 glycinates Chemical class 0.000 claims description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 235000003599 food sweetener Nutrition 0.000 claims description 13
- 239000003765 sweetening agent Substances 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
- 239000006172 buffering agent Substances 0.000 claims description 11
- 235000019634 flavors Nutrition 0.000 claims description 11
- 235000013355 food flavoring agent Nutrition 0.000 claims description 11
- 239000003963 antioxidant agent Substances 0.000 claims description 10
- 235000006708 antioxidants Nutrition 0.000 claims description 10
- 239000012458 free base Substances 0.000 claims description 10
- 210000000214 mouth Anatomy 0.000 claims description 10
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 7
- 239000000905 isomalt Substances 0.000 claims description 7
- 235000010439 isomalt Nutrition 0.000 claims description 7
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 7
- 239000000314 lubricant Substances 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 7
- 239000000454 talc Substances 0.000 claims description 6
- 229910052623 talc Inorganic materials 0.000 claims description 6
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 5
- 239000008368 mint flavor Substances 0.000 claims description 5
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- 108010011485 Aspartame Proteins 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 4
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 4
- 230000000181 anti-adherent effect Effects 0.000 claims description 4
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 150000001860 citric acid derivatives Chemical class 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 235000010356 sorbitol Nutrition 0.000 claims description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims description 4
- 241000195493 Cryptophyta Species 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 239000008122 artificial sweetener Substances 0.000 claims description 3
- 235000021311 artificial sweeteners Nutrition 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000003925 fat Substances 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 239000001993 wax Substances 0.000 claims description 3
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 3
- QLDPCHZQQIASHX-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.CN1CCCC1C1=CC=CN=C1 QLDPCHZQQIASHX-UHFFFAOYSA-N 0.000 claims description 2
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims description 2
- MQWJVKLIBZWVEL-XRIOVQLTSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;dihydrochloride Chemical compound Cl.Cl.CN1CCC[C@H]1C1=CC=CN=C1 MQWJVKLIBZWVEL-XRIOVQLTSA-N 0.000 claims description 2
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 claims description 2
- YHBIGBYIUMCLJS-UHFFFAOYSA-N 5-fluoro-1,3-benzothiazol-2-amine Chemical compound FC1=CC=C2SC(N)=NC2=C1 YHBIGBYIUMCLJS-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 244000166124 Eucalyptus globulus Species 0.000 claims description 2
- 206010057852 Nicotine dependence Diseases 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 208000025569 Tobacco Use disease Diseases 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 229960005164 acesulfame Drugs 0.000 claims description 2
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims description 2
- 150000001242 acetic acid derivatives Chemical class 0.000 claims description 2
- 230000009471 action Effects 0.000 claims description 2
- 150000001642 boronic acid derivatives Chemical class 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 150000002315 glycerophosphates Chemical class 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 150000002739 metals Chemical class 0.000 claims description 2
- 229940069688 nicotine bitartrate Drugs 0.000 claims description 2
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 235000021317 phosphate Nutrition 0.000 claims description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 229940081974 saccharin Drugs 0.000 claims description 2
- 235000019204 saccharin Nutrition 0.000 claims description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 2
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 2
- 229960005055 sodium ascorbate Drugs 0.000 claims description 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000006068 taste-masking agent Substances 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- FGAFEHZTRRYNDF-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride Chemical compound [Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 FGAFEHZTRRYNDF-UHFFFAOYSA-L 0.000 claims description 2
- BRTHFWPGJMGHIV-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride;hydrate Chemical compound O.[Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 BRTHFWPGJMGHIV-UHFFFAOYSA-L 0.000 claims description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- 150000001579 beta-carotenes Chemical class 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
- 239000000473 propyl gallate Substances 0.000 claims 1
- 229940075579 propyl gallate Drugs 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000019149 tocopherols Nutrition 0.000 claims 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims 1
- 238000001727 in vivo Methods 0.000 description 13
- 239000000047 product Substances 0.000 description 11
- 241000208125 Nicotiana Species 0.000 description 9
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 238000007922 dissolution test Methods 0.000 description 8
- 239000012928 buffer substance Substances 0.000 description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 230000001186 cumulative effect Effects 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 230000000391 smoking effect Effects 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 239000004411 aluminium Substances 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000000099 in vitro assay Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011236 particulate material Substances 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920001592 potato starch Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000008299 semisolid dosage form Substances 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 239000007909 solid dosage form Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- IRJNJBIOUYJBHG-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.CN1CCCC1C1=CC=CN=C1 IRJNJBIOUYJBHG-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 241001478778 Cladophora Species 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 229920002488 Hemicellulose Polymers 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 235000010358 acesulfame potassium Nutrition 0.000 description 2
- 229960004998 acesulfame potassium Drugs 0.000 description 2
- 239000000619 acesulfame-K Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000019788 craving Nutrition 0.000 description 2
- 239000012738 dissolution medium Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000002657 fibrous material Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000004922 lacquer Substances 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical group OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 244000165918 Eucalyptus papuana Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000009506 drug dissolution testing Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229940015769 nicotine chewing gum Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
- Manufacture Of Tobacco Products (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78290306P | 2006-03-16 | 2006-03-16 | |
| DKPA200600375 | 2006-03-16 | ||
| US60/782,903 | 2006-03-16 | ||
| DKPA200600375 | 2006-03-16 | ||
| PCT/EP2007/002344 WO2007104574A2 (en) | 2006-03-16 | 2007-03-16 | Chewing gum compositions providing rapid release of nicotine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2646230A1 true CA2646230A1 (en) | 2007-09-20 |
Family
ID=38357118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002646230A Abandoned CA2646230A1 (en) | 2006-03-16 | 2007-03-16 | Chewing gum compositions providing rapid release of nicotine |
| CA002657932A Abandoned CA2657932A1 (en) | 2006-03-16 | 2007-03-16 | Stable lozenge compositions providing rapid release of nicotine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002657932A Abandoned CA2657932A1 (en) | 2006-03-16 | 2007-03-16 | Stable lozenge compositions providing rapid release of nicotine |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100061940A1 (enExample) |
| EP (2) | EP1998754A2 (enExample) |
| JP (2) | JP2009529561A (enExample) |
| AU (2) | AU2007224586A1 (enExample) |
| CA (2) | CA2646230A1 (enExample) |
| WO (2) | WO2007104575A2 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1578422B1 (en) | 2002-12-20 | 2007-04-11 | NicoNovum AB | A physically and chemically stable nicotine and micorcrystalline cellulose containing particulate material |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| EP1977746B8 (en) * | 2007-04-02 | 2014-09-24 | Parkinson's Institute | Methods and compositions for reduction of side effects of therapeutic treatments |
| GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
| CA2699806A1 (en) * | 2007-09-18 | 2009-03-26 | Niconovum Ab | Stable chewing gum compositions comprising maltitol and providing rapid release of nicotine |
| US9023322B2 (en) | 2008-03-26 | 2015-05-05 | Stichting Sanammad | Chewing gum compositions comprising cannabinoids |
| CL2009001025A1 (es) | 2008-05-01 | 2010-09-24 | Smithkline Beecham Corp | Composicion de pastilla para chupar que comprende: a) un granulo patron con al menos: un agente tampon alcalino, un modificador de la disolucion y una carga, b) un principio activo de nicotina definido extragranular y al menos un agente tampon alcalino; procedimiento de preparacion; util para eliminar o reducir el uso de tabaco. |
| EP2293786B1 (en) * | 2008-05-21 | 2014-11-26 | Novartis AG | Tablettable chewing gums comprising nicotine and a buffering agent |
| US8833378B2 (en) | 2008-09-17 | 2014-09-16 | Niconovum Ab | Process for preparing snuff composition |
| US8784781B2 (en) * | 2009-09-24 | 2014-07-22 | Mcneil-Ppc, Inc. | Manufacture of chewing gum product with radiofrequency |
| EP2536409A4 (en) * | 2010-02-18 | 2013-07-17 | Jatin Vasant Thakkar | NICOTINE-CONTAINING SOFT GELATINETABLETTEN |
| US8952038B2 (en) | 2010-03-26 | 2015-02-10 | Philip Morris Usa Inc. | Inhibition of undesired sensory effects by the compound camphor |
| US20110268809A1 (en) * | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) * | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| WO2013109961A1 (en) * | 2012-01-20 | 2013-07-25 | Altria Client Services Inc. | Oral product |
| CN103039688B (zh) | 2012-01-20 | 2016-01-06 | 奥驰亚客户服务公司 | 口腔用产品 |
| US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
| CN103040090B (zh) | 2012-01-20 | 2016-03-30 | 奥驰亚客户服务公司 | 脱除烟草的口腔用产品 |
| CN102754908B (zh) | 2012-01-20 | 2015-06-10 | 奥驰亚客户服务公司 | 口腔用烟草产品 |
| CN102754907B (zh) | 2012-01-20 | 2015-06-24 | 奥驰亚客户服务公司 | 口腔用产品 |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US12285025B2 (en) | 2012-02-10 | 2025-04-29 | R.J. Reynolds Tobacco Company | Multi-layer smokeless tobacco composition |
| SE536491C2 (sv) * | 2012-03-26 | 2013-12-27 | Bionicotine Ab | Påse innehållande nikotin och en tuggummikomposition |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| US9339058B2 (en) | 2012-04-19 | 2016-05-17 | R. J. Reynolds Tobacco Company | Method for producing microcrystalline cellulose from tobacco and related tobacco product |
| US9445971B2 (en) | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
| US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
| US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
| US20140255452A1 (en) | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
| AR096223A1 (es) | 2013-05-10 | 2015-12-16 | Glaxosmithkline Llc | Pastilla de nicotina para administración oral |
| CN111249584B (zh) | 2013-07-11 | 2022-04-26 | 艾利斯达医药品公司 | 与间水杨酸形成的烟碱盐 |
| EP3622834A1 (en) | 2013-07-19 | 2020-03-18 | Altria Client Services LLC | Methods and systems for incorporating nicotine into oral products |
| US11503853B2 (en) | 2013-09-09 | 2022-11-22 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition incorporating a botanical material |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| CN103549646B (zh) * | 2013-11-11 | 2016-03-02 | 云南烟草科学研究院 | 含烟草超微粉末的口崩片型无烟烟草制品及其制备方法 |
| RU2712267C2 (ru) | 2014-01-10 | 2020-01-28 | Джонсон энд Джонсон Консьюмер Инк. | Способ изготовления таблеток с использованием радиочастотного излучения и частиц с поглощающим покрытием |
| EP4603486A3 (en) | 2014-05-27 | 2025-10-15 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US10959456B2 (en) | 2014-09-12 | 2021-03-30 | R.J. Reynolds Tobacco Company | Nonwoven pouch comprising heat sealable binder fiber |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 薬剤送達方法及びシステム |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| US10881133B2 (en) | 2015-04-16 | 2021-01-05 | R.J. Reynolds Tobacco Company | Tobacco-derived cellulosic sugar |
| US10869497B2 (en) | 2015-09-08 | 2020-12-22 | R.J. Reynolds Tobacco Company | High-pressure cold pasteurization of tobacco material |
| US20170172995A1 (en) * | 2015-09-08 | 2017-06-22 | Venkateswara Rao Repaka | Pharmaceutical compositions of Nicotine and process for preparation thereof |
| US10485247B2 (en) | 2015-10-07 | 2019-11-26 | Fertin Pharma A/S | Chewing gum comprising nicotine |
| EP4338735B1 (en) | 2015-11-25 | 2026-02-04 | R. J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US10532046B2 (en) | 2015-12-03 | 2020-01-14 | Niconovum Usa, Inc. | Multi-phase delivery compositions and products incorporating such compositions |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| US10499684B2 (en) | 2016-01-28 | 2019-12-10 | R.J. Reynolds Tobacco Company | Tobacco-derived flavorants |
| US11154087B2 (en) | 2016-02-02 | 2021-10-26 | R.J. Reynolds Tobacco Company | Method for preparing flavorful compounds isolated from black liquor and products incorporating the flavorful compounds |
| WO2018122095A1 (en) | 2016-12-30 | 2018-07-05 | Philip Morris Products S.A. | Nicotine and cellulose containing sheet |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| US11091446B2 (en) | 2017-03-24 | 2021-08-17 | R.J. Reynolds Tobacco Company | Methods of selectively forming substituted pyrazines |
| PL3681865T3 (pl) | 2017-09-05 | 2026-02-23 | R. J. Reynolds Tobacco Company | Sole, kokryształy i kompleksy kokryształów soli nikotyny |
| US20190307082A1 (en) | 2018-04-05 | 2019-10-10 | R.J. Reynolds Tobacco Company | Oriental tobacco production methods |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| DK3807260T3 (da) | 2018-06-15 | 2024-10-14 | Reynolds Tobacco Co R | Oprensning af nikotin |
| JP2022507660A (ja) | 2018-11-16 | 2022-01-18 | モーニングサイド ベンチャー インベストメンツ リミテッド | 温度によって調節される経皮薬剤送達システム |
| US12342847B2 (en) | 2019-09-11 | 2025-07-01 | Nicoventures Trading Limited | Oral product with cellulosic flavor stabilizer |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| US12151023B2 (en) | 2019-12-09 | 2024-11-26 | Nicoventures Trading Limited | Oral composition with beet material |
| MX2022006906A (es) | 2019-12-09 | 2022-08-16 | Nicoventures Trading Ltd | Composiciones orales y metodos de fabricacion. |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US12491250B2 (en) | 2019-12-09 | 2025-12-09 | Nicoventures Trading Limited | Oral composition with nanocrystalline cellulose |
| EP4072516A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Oral product comprising a cannabinoid |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| US11883527B2 (en) | 2019-12-09 | 2024-01-30 | Nicoventures Trading Limited | Oral composition and method of manufacture |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| US11672862B2 (en) | 2019-12-09 | 2023-06-13 | Nicoventures Trading Limited | Oral products with reduced irritation |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US12137723B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Oral products with active ingredient combinations |
| US12550928B2 (en) | 2019-12-09 | 2026-02-17 | Nicoventures Trading Limited | Liquid oral composition |
| US12171872B2 (en) | 2019-12-09 | 2024-12-24 | Nicoventures Trading Limited | Oral compositions and methods of manufacture |
| US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| US12691059B2 (en) | 2019-12-09 | 2026-07-28 | Nicoventures Trading Limited | Oral composition with polymeric component |
| US11889856B2 (en) | 2019-12-09 | 2024-02-06 | Nicoventures Trading Limited | Oral foam composition |
| JP2023505351A (ja) | 2019-12-09 | 2023-02-08 | ニコベンチャーズ トレーディング リミテッド | 口腔用組成物のための薬剤 |
| US12599160B2 (en) | 2019-12-09 | 2026-04-14 | Nicoventures Trading Limited | Lipid-containing oral composition |
| US12520867B2 (en) | 2019-12-09 | 2026-01-13 | Nicoventures Trading Limited | Buffered oral compositions |
| SE544672C2 (en) | 2020-05-07 | 2022-10-11 | Liw Innovation Ab | New compositions for oral or nasal use |
| JP2023530239A (ja) | 2020-06-08 | 2023-07-14 | ニコベンチャーズ トレーディング リミテッド | 発泡性口腔組成物 |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| CA3211601A1 (en) | 2021-03-09 | 2022-09-15 | Jr. Darrell Eugene Holton | Oral products and methods of manufacture |
| US20220354785A1 (en) | 2021-04-22 | 2022-11-10 | Nicoventures Trading Limited | Oral lozenge products |
| WO2022234522A1 (en) | 2021-05-06 | 2022-11-10 | Nicoventures Trading Limited | Oral compositions and related methods for reducing throat irritation |
| US12382982B2 (en) | 2021-06-25 | 2025-08-12 | Nicoventures Trading Limited | Oral products and method of manufacture |
| CN119789793A (zh) | 2021-07-30 | 2025-04-08 | 尼科凡图尔斯贸易有限公司 | 包含微晶纤维素的气溶胶发生基材 |
| JP2024536230A (ja) | 2021-09-30 | 2024-10-04 | ニコベンチャーズ トレーディング リミテッド | 塩基性アミン及びイオン対形成剤を含む口腔用製品 |
| EP4408184A1 (en) | 2021-09-30 | 2024-08-07 | Nicoventures Trading Limited | Oral gum composition |
| MX2024005869A (es) | 2021-11-15 | 2024-07-15 | Nicoventures Trading Ltd | Productos con caracteristicas sensoriales mejoradas. |
| US12295412B2 (en) | 2022-01-28 | 2025-05-13 | Altria Client Services Llc | Oral pouch product |
| US20250241356A1 (en) | 2022-06-24 | 2025-07-31 | Michael S. Daniel | Oral composition comprising receptor modulator |
| JP2025533087A (ja) | 2022-10-07 | 2025-10-03 | ニコベンチャーズ トレーディング リミテッド | 経口製剤 |
| GB202214775D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| EP4598366A1 (en) | 2022-10-07 | 2025-08-13 | Nicoventures Trading Limited | Oral product |
| WO2024074843A1 (en) | 2022-10-07 | 2024-04-11 | Nicoventures Trading Limited | Oral product |
| GB202214803D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| GB202214771D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| WO2024095163A1 (en) | 2022-11-01 | 2024-05-10 | Nicoventures Trading Limited | Oral composition comprising encapsulated ph adjusting agent |
| JP2025535900A (ja) | 2022-11-04 | 2025-10-30 | ニコベンチャーズ トレーディング リミテッド | 経口製品 |
| GB202216465D0 (en) | 2022-11-04 | 2022-12-21 | Nicoventures Trading Ltd | Oral product |
| CN115997965A (zh) * | 2023-02-09 | 2023-04-25 | 东莞市吉纯生物技术有限公司 | 一种尼古丁缓释型口含烟及其制备方法 |
| EP4672985A1 (en) | 2023-02-28 | 2026-01-07 | Nicoventures Trading Limited | Caffeine-containing oral product |
| GB202304445D0 (en) | 2023-03-27 | 2023-05-10 | Nicoventures Trading Ltd | Oral product |
| GB202307279D0 (en) | 2023-05-16 | 2023-06-28 | Nicoventures Trading Ltd | Oral product |
| GB202307278D0 (en) | 2023-05-16 | 2023-06-28 | Nicoventures Holdings Ltd | Oral product |
| EP4585055A1 (en) | 2024-01-12 | 2025-07-16 | Nicoventures Trading Limited | Oral product with probiotic component |
| EP4599698A1 (en) | 2024-02-07 | 2025-08-13 | Nicoventures Trading Limited | Products comprising sensory agents |
| EP4602929A1 (en) | 2024-02-19 | 2025-08-20 | Nicoventures Trading Limited | Oral product with powder coating |
| EP4623708A1 (en) | 2024-03-26 | 2025-10-01 | Nicoventures Trading Limited | Sweetener composition for pouched oral products |
| EP4623702A1 (en) | 2024-03-27 | 2025-10-01 | Nicoventures Trading Limited | Oral product |
| EP4631502A1 (en) | 2024-04-12 | 2025-10-15 | Nicoventures Trading Limited | Use of flavones such as quercetin to increase cognitive function and to reduce jitterness |
| WO2026013602A1 (en) | 2024-07-10 | 2026-01-15 | Rai Strategic Holdings, Inc. | Oral products |
| EP4714267A1 (en) | 2024-09-19 | 2026-03-25 | Bharat Mehta | A nicotine based gum formulation |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
| GB8615676D0 (en) * | 1986-06-26 | 1986-07-30 | Stoppers Co Ltd | Nicotine containing lozenge |
| US5488962A (en) * | 1990-10-10 | 1996-02-06 | Perfetti, S.P.A. | Chewing gum which is a substitute for tobacco smoke |
| US5549906A (en) * | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5362496A (en) * | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| SE0102197D0 (sv) * | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| US20040101543A1 (en) * | 2002-03-22 | 2004-05-27 | John Liu | Nicotine-containing oral dosage form |
| EP1578422B1 (en) * | 2002-12-20 | 2007-04-11 | NicoNovum AB | A physically and chemically stable nicotine and micorcrystalline cellulose containing particulate material |
| JP5283334B2 (ja) * | 2003-01-24 | 2013-09-04 | マグル ホールディング エービー | 経粘膜伝達用組成物材料 |
| DK1663168T3 (da) * | 2003-09-08 | 2009-06-08 | Mcneil Ab | Nikotinformuleringer og anvendelse deraf |
| WO2005053691A2 (en) * | 2003-12-02 | 2005-06-16 | Fertin Pharma A/S | Nicotine delivery product and method for producing it |
| DE602005015446D1 (de) * | 2004-06-29 | 2009-08-27 | Fertin Pharma As | Tabakalkaloid freisetzendes kaugummi |
-
2007
- 2007-03-16 AU AU2007224586A patent/AU2007224586A1/en not_active Abandoned
- 2007-03-16 JP JP2008558730A patent/JP2009529561A/ja not_active Withdrawn
- 2007-03-16 JP JP2008558729A patent/JP2009529343A/ja active Pending
- 2007-03-16 EP EP07711967A patent/EP1998754A2/en not_active Withdrawn
- 2007-03-16 WO PCT/EP2007/002345 patent/WO2007104575A2/en not_active Ceased
- 2007-03-16 WO PCT/EP2007/002344 patent/WO2007104574A2/en not_active Ceased
- 2007-03-16 EP EP07723324A patent/EP1998755A2/en not_active Withdrawn
- 2007-03-16 AU AU2007224585A patent/AU2007224585A1/en not_active Abandoned
- 2007-03-16 US US12/225,260 patent/US20100061940A1/en not_active Abandoned
- 2007-03-16 CA CA002646230A patent/CA2646230A1/en not_active Abandoned
- 2007-03-16 CA CA002657932A patent/CA2657932A1/en not_active Abandoned
- 2007-09-16 US US12/226,273 patent/US20100004294A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007104574A3 (en) | 2008-01-10 |
| AU2007224585A1 (en) | 2007-09-20 |
| EP1998755A2 (en) | 2008-12-10 |
| EP1998754A2 (en) | 2008-12-10 |
| WO2007104575A3 (en) | 2008-01-10 |
| CA2657932A1 (en) | 2007-09-20 |
| US20100061940A1 (en) | 2010-03-11 |
| WO2007104575A2 (en) | 2007-09-20 |
| WO2007104574A2 (en) | 2007-09-20 |
| US20100004294A1 (en) | 2010-01-07 |
| JP2009529561A (ja) | 2009-08-20 |
| JP2009529343A (ja) | 2009-08-20 |
| AU2007224586A1 (en) | 2007-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20100061940A1 (en) | Chewing Gum Compositions Providing Rapid Release of Nicotine | |
| US20100260690A1 (en) | Stable chewing gum compositions comprising maltitol and providing rapid release of nicotine | |
| US20230009314A1 (en) | Snuff composition | |
| US9763929B2 (en) | Tablettable chewing gums | |
| EP0707478B1 (en) | Improved nicotine lozenge | |
| US8833378B2 (en) | Process for preparing snuff composition | |
| ES2968706T3 (es) | Una combinación de nicotina y celulosa | |
| CN101437497A (zh) | 提供迅速释放尼古丁的口香糖组合物 | |
| JP2009529561A5 (enExample) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |