CA2644642C - A process for concentration of a polypeptide - Google Patents

A process for concentration of a polypeptide Download PDF

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Publication number
CA2644642C
CA2644642C CA2644642A CA2644642A CA2644642C CA 2644642 C CA2644642 C CA 2644642C CA 2644642 A CA2644642 A CA 2644642A CA 2644642 A CA2644642 A CA 2644642A CA 2644642 C CA2644642 C CA 2644642C
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Canada
Prior art keywords
composition
polypeptide
colour
interest
clarity
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Application number
CA2644642A
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English (en)
French (fr)
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CA2644642A1 (en
Inventor
Stefan Nilsson
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Chiesi Farmaceutici SpA
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Zymenex AS
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Priority to CA2882501A priority Critical patent/CA2882501C/en
Publication of CA2644642A1 publication Critical patent/CA2644642A1/en
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Publication of CA2644642C publication Critical patent/CA2644642C/en
Active legal-status Critical Current
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y205/00Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01061Hydroxymethylbilane synthase (2.5.1.61)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06001Arylsulfatase (3.1.6.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024Alpha-mannosidase (3.2.1.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01046Galactosylceramidase (3.2.1.46)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06008Cerebroside-sulfatase (3.1.6.8)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Water Supply & Treatment (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2644642A 2006-04-04 2007-04-04 A process for concentration of a polypeptide Active CA2644642C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2882501A CA2882501C (en) 2006-04-04 2007-04-04 Compositions comprising alpha mannosidase and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200600488 2006-04-04
DKPA200600488 2006-04-04
DKPA200600922 2006-07-05
DKPA200600922 2006-07-05
CA2632528A CA2632528C (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2632528A Division CA2632528C (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2882501A Division CA2882501C (en) 2006-04-04 2007-04-04 Compositions comprising alpha mannosidase and uses thereof

Publications (2)

Publication Number Publication Date
CA2644642A1 CA2644642A1 (en) 2007-10-11
CA2644642C true CA2644642C (en) 2016-01-26

Family

ID=38472949

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2644642A Active CA2644642C (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
CA2882501A Active CA2882501C (en) 2006-04-04 2007-04-04 Compositions comprising alpha mannosidase and uses thereof
CA2632528A Active CA2632528C (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2882501A Active CA2882501C (en) 2006-04-04 2007-04-04 Compositions comprising alpha mannosidase and uses thereof
CA2632528A Active CA2632528C (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide

Country Status (20)

Country Link
US (6) US20090246187A1 (enExample)
EP (4) EP2004672B1 (enExample)
JP (6) JP2009532394A (enExample)
KR (3) KR20150103339A (enExample)
CN (1) CN105233276A (enExample)
AU (2) AU2007234195B2 (enExample)
BR (1) BRPI0709737A2 (enExample)
CA (3) CA2644642C (enExample)
DK (1) DK2628746T3 (enExample)
ES (3) ES2713488T3 (enExample)
HU (1) HUE042402T2 (enExample)
IL (4) IL194267A (enExample)
MX (1) MX2008012748A (enExample)
NO (3) NO347673B1 (enExample)
NZ (7) NZ607595A (enExample)
PL (3) PL2631242T3 (enExample)
PT (1) PT2628746T (enExample)
SI (1) SI2628746T1 (enExample)
WO (1) WO2007112757A2 (enExample)
ZA (2) ZA200805346B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ548871A (en) 2004-01-30 2009-06-26 Shire Pharmaceuticals Ireland Use of arylsulfatase A for treating metachromatic leukodystrophy
PL2631242T3 (pl) * 2006-04-04 2023-03-20 Takeda Pharmaceutical Company Limited Sposób zatężania polipeptydu
EA022220B1 (ru) * 2010-02-24 2015-11-30 Сюменекс А/С Способ получения и очистки рекомбинантной лизосомальной альфа-маннозидазы
DK2588130T3 (en) * 2010-06-25 2016-10-24 Shire Human Genetic Therapies Cns delivery of therapeutic agents
PT3626258T (pt) 2010-06-25 2021-10-19 Shire Human Genetic Therapies Métodos e composições para fornecimento ao snc de iduronato-2-sulfatase
MX2013000320A (es) 2010-06-25 2013-06-05 Shire Human Genetic Therapies Composiciones y metodos para suministro al sistema nervioso central de heparan n-sulfatasa.
NZ605873A (en) * 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of arylsulfatase a
US10336992B2 (en) 2011-07-08 2019-07-02 Shire Human Genetic Therapies, Inc. Methods for purification of arylsulfatase A
WO2013096899A2 (en) 2011-12-23 2013-06-27 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
NZ707753A (en) * 2012-11-13 2019-07-26 Chiesi Farm Spa Purification of recombinant human galactocerebroside β-galactosidase (rhgalc)
EP2932274B1 (en) * 2012-12-11 2020-01-15 Centogene AG Method for the diagnosis of metachromatic leukodystrophy
CN119979504A (zh) 2013-01-09 2025-05-13 武田药品工业株式会社 含用于纯化芳基硫酸酯酶a的方法
EA037906B1 (ru) 2013-03-15 2021-06-04 Биовератив Терапьютикс Инк. Препараты полипептида фактора ix
SG10201913735SA (en) 2014-03-24 2020-03-30 Bioverativ Therapeutics Inc Lyophilized factor ix formulations
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein
KR102290596B1 (ko) * 2020-09-10 2021-08-19 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도

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CA2041280A1 (en) 1990-05-10 1991-11-11 Yosuke Sawada Arylsulfatase
NO960163D0 (no) 1996-01-15 1996-01-15 Thomas Berg Mutasjonsdeteksjon av bovin
EP1049487B1 (en) 1998-01-27 2002-05-22 Hemebiotech A/S Treatment of acute intermittent porphyria (aip) and other porphyric diseases
ES2421736T3 (es) * 1998-06-09 2013-09-05 Csl Behring Ag Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos
PL196770B1 (pl) * 1998-06-09 2008-01-31 Statens Seruminstitut Sposób oczyszczania immunoglobuliny, produkt immunoglobuliny i jego zastosowanie
US6537777B1 (en) 1998-07-27 2003-03-25 Hemebiotech A/S Human porphobilinogen deaminase sequences
AUPQ026799A0 (en) * 1999-05-10 1999-06-03 Csl Limited Method of increasing protein stability by removing immunoglobulin aggregates
JP2003505057A (ja) 1999-07-27 2003-02-12 ヘム−バイオテック エイ/エス rhPBGDの製造及び急性間欠性ポルフィリン症(AIP)及び他のポルフィリン症の患者を処置するための新規な治療方法
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
EP1409695A2 (en) 2000-11-15 2004-04-21 Genzyme Corporation Expression system for recombinant proteins
AU2002317701A1 (en) 2001-06-07 2002-12-16 Hemebiotech A/S Production of recombinant human lysosomal alpha-mannosidase
AU2002317700A1 (en) * 2001-06-07 2002-12-16 Hemebiotech A/S Production of recombinant human arylsulfatase a
WO2003002731A1 (en) * 2001-06-29 2003-01-09 Hemebiotech A/S A PROCESS FOR PURIFICATION OF RECOMBINANT PORPHOBILINOGEN DEAMINASE (rhPBGD)
US7232670B2 (en) * 2001-09-28 2007-06-19 St. Jude Children's Research Hospital Targeting proteins to cells expressing mannose receptors via expression in insect cells
EP1463512B1 (en) 2002-01-11 2014-05-28 biOasis Technologies Inc. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
WO2003066669A2 (en) * 2002-02-04 2003-08-14 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
CH694697A5 (de) 2004-01-29 2005-06-15 Koelbl Engineering Und Consult Gummimehl-enthaltende Elastomerlegierungen.
NZ548871A (en) 2004-01-30 2009-06-26 Shire Pharmaceuticals Ireland Use of arylsulfatase A for treating metachromatic leukodystrophy
WO2005094874A1 (en) 2004-04-01 2005-10-13 Zymenex A/S Medical use of alpha-mannosidase
US20060051347A1 (en) * 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
PL2631242T3 (pl) * 2006-04-04 2023-03-20 Takeda Pharmaceutical Company Limited Sposób zatężania polipeptydu

Also Published As

Publication number Publication date
BRPI0709737A2 (pt) 2011-07-26
JP2013236633A (ja) 2013-11-28
IL194267A (en) 2015-10-29
PL2628746T3 (pl) 2019-07-31
CA2632528C (en) 2022-07-12
WO2007112757A3 (en) 2008-02-28
NO347673B1 (no) 2024-02-19
JP2014058521A (ja) 2014-04-03
US20180289777A1 (en) 2018-10-11
CA2632528A1 (en) 2007-10-11
JP2009273469A (ja) 2009-11-26
KR20150103339A (ko) 2015-09-09
NO20211305A1 (no) 2008-10-31
NO20082510L (no) 2008-10-31
US20090246187A1 (en) 2009-10-01
CA2882501A1 (en) 2007-10-11
NZ597548A (en) 2013-08-30
JP2016104000A (ja) 2016-06-09
IL241654A0 (en) 2015-11-30
NZ582045A (en) 2011-07-29
NZ623123A (en) 2015-04-24
KR20090018894A (ko) 2009-02-24
AU2007234195B2 (en) 2013-02-07
KR101504969B1 (ko) 2015-03-24
KR20140057678A (ko) 2014-05-13
AU2007234195A1 (en) 2007-10-11
ES2713488T3 (es) 2019-05-22
NZ571610A (en) 2011-07-29
EP2631242A3 (en) 2013-10-02
EP2004672B1 (en) 2015-08-19
NO346368B1 (no) 2022-06-27
MX2008012748A (es) 2009-01-07
NZ588903A (en) 2012-08-31
US20160193304A1 (en) 2016-07-07
EP2100898A1 (en) 2009-09-16
CN105233276A (zh) 2016-01-13
US20140314735A1 (en) 2014-10-23
NZ568728A (en) 2011-09-30
ZA200805346B (en) 2018-11-28
EP2628746A3 (en) 2014-03-19
JP5384232B2 (ja) 2014-01-08
US9713634B2 (en) 2017-07-25
IL211905A0 (en) 2011-05-31
PL2631242T3 (pl) 2023-03-20
ES2744499T3 (es) 2020-02-25
CA2644642A1 (en) 2007-10-11
EP2628746A2 (en) 2013-08-21
US20170202927A1 (en) 2017-07-20
IL235982A0 (en) 2015-01-29
EP2628746B1 (en) 2019-01-09
IL241654B (en) 2019-02-28
JP2014051503A (ja) 2014-03-20
ZA200809540B (en) 2019-09-25
EP2631242B1 (en) 2022-08-03
HUE042402T2 (hu) 2019-06-28
WO2007112757A2 (en) 2007-10-11
ES2928096T3 (es) 2022-11-15
PT2628746T (pt) 2019-04-23
US8809055B2 (en) 2014-08-19
AU2008229659A1 (en) 2008-10-23
AU2008229659B2 (en) 2013-01-31
NZ607595A (en) 2014-10-31
EP2004672A2 (en) 2008-12-24
DK2628746T3 (en) 2019-04-01
PL2100898T3 (pl) 2019-11-29
JP5878152B2 (ja) 2016-03-08
US20120076767A1 (en) 2012-03-29
CA2882501C (en) 2021-09-07
SI2628746T1 (sl) 2019-04-30
JP2009532394A (ja) 2009-09-10
EP2100898B1 (en) 2019-06-19
EP2631242A2 (en) 2013-08-28
NO20084776L (no) 2008-10-31
IL194267A0 (en) 2011-08-01

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