CA2643507A1 - Novel dibenzo[c,h][1,5]naphthyridines and their use as dna probes - Google Patents
Novel dibenzo[c,h][1,5]naphthyridines and their use as dna probes Download PDFInfo
- Publication number
- CA2643507A1 CA2643507A1 CA002643507A CA2643507A CA2643507A1 CA 2643507 A1 CA2643507 A1 CA 2643507A1 CA 002643507 A CA002643507 A CA 002643507A CA 2643507 A CA2643507 A CA 2643507A CA 2643507 A1 CA2643507 A1 CA 2643507A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- dibenzo
- naphthyridin
- oalkyl
- diamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000523 sample Substances 0.000 title claims 8
- 150000005054 naphthyridines Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 7
- 239000003298 DNA probe Substances 0.000 claims abstract 2
- 125000006373 (C2-C10) alkyl group Chemical group 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 150000004677 hydrates Chemical class 0.000 claims 8
- 230000003287 optical effect Effects 0.000 claims 8
- 238000002372 labelling Methods 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- NEKJVVMBQDHMGD-UHFFFAOYSA-N 2-methyl-1-(methylamino)-1-(1,5-naphthyridin-2-yl)propane-1,3-diol Chemical compound N1=CC=CC2=NC(C(O)(C(C)CO)NC)=CC=C21 NEKJVVMBQDHMGD-UHFFFAOYSA-N 0.000 claims 2
- 108020003215 DNA Probes Proteins 0.000 claims 1
- NOMAHMSWPGERKB-UHFFFAOYSA-N N1=CC=CC2=NC(=CC=C12)C(CN)(N(C)C)C Chemical compound N1=CC=CC2=NC(=CC=C12)C(CN)(N(C)C)C NOMAHMSWPGERKB-UHFFFAOYSA-N 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000008366 buffered solution Substances 0.000 claims 1
- 239000013592 cell lysate Substances 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 210000001822 immobilized cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 102220067365 rs143592561 Human genes 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 210000001138 tear Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- VMLKTERJLVWEJJ-UHFFFAOYSA-N 1,5-naphthyridine Chemical compound C1=CC=NC2=CC=CN=C21 VMLKTERJLVWEJJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06290322.4 | 2006-02-27 | ||
| EP06290322A EP1826210A1 (en) | 2006-02-27 | 2006-02-27 | Novel dibenzo[c,h][1,5]naphthyridines and their use as DNA probes |
| PCT/IB2007/000360 WO2007096728A1 (en) | 2006-02-27 | 2007-02-15 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2643507A1 true CA2643507A1 (en) | 2007-08-30 |
Family
ID=36593091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002643507A Abandoned CA2643507A1 (en) | 2006-02-27 | 2007-02-15 | Novel dibenzo[c,h][1,5]naphthyridines and their use as dna probes |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7728128B2 (enExample) |
| EP (2) | EP1826210A1 (enExample) |
| JP (1) | JP5222158B2 (enExample) |
| AT (1) | ATE530548T1 (enExample) |
| CA (1) | CA2643507A1 (enExample) |
| WO (1) | WO2007096728A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0747414B2 (ja) | 1991-05-31 | 1995-05-24 | 日東精工株式会社 | 連続熱処理炉の部品投入装置 |
| JP2880972B2 (ja) | 1996-11-22 | 1999-04-12 | 四国工業株式会社 | 液体に含まれるスラッジの分離装置 |
| WO2012023487A1 (ja) * | 2010-08-18 | 2012-02-23 | 学校法人同志社 | 金属錯体、蛍光プローブ |
| KR101909680B1 (ko) * | 2015-04-10 | 2018-10-18 | 삼성에스디아이 주식회사 | 화합물, 이를 포함하는 유기 광전자 소자 및 표시장치 |
-
2006
- 2006-02-27 EP EP06290322A patent/EP1826210A1/en not_active Withdrawn
-
2007
- 2007-02-15 US US12/280,715 patent/US7728128B2/en not_active Expired - Fee Related
- 2007-02-15 CA CA002643507A patent/CA2643507A1/en not_active Abandoned
- 2007-02-15 JP JP2008555888A patent/JP5222158B2/ja not_active Expired - Fee Related
- 2007-02-15 EP EP07705594A patent/EP1991546B1/en not_active Not-in-force
- 2007-02-15 AT AT07705594T patent/ATE530548T1/de not_active IP Right Cessation
- 2007-02-15 WO PCT/IB2007/000360 patent/WO2007096728A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1991546A1 (en) | 2008-11-19 |
| EP1826210A1 (en) | 2007-08-29 |
| JP2009528287A (ja) | 2009-08-06 |
| WO2007096728A1 (en) | 2007-08-30 |
| US20090246772A1 (en) | 2009-10-01 |
| ATE530548T1 (de) | 2011-11-15 |
| EP1991546B1 (en) | 2011-10-26 |
| JP5222158B2 (ja) | 2013-06-26 |
| US7728128B2 (en) | 2010-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160115 |