CA2641916A1 - Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors - Google Patents
Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors Download PDFInfo
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- CA2641916A1 CA2641916A1 CA002641916A CA2641916A CA2641916A1 CA 2641916 A1 CA2641916 A1 CA 2641916A1 CA 002641916 A CA002641916 A CA 002641916A CA 2641916 A CA2641916 A CA 2641916A CA 2641916 A1 CA2641916 A1 CA 2641916A1
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- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 150000004291 polyenes Polymers 0.000 description 1
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- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 230000000069 prophylactic effect Effects 0.000 description 1
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- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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- 230000000697 serotonin reuptake Effects 0.000 description 1
- 230000013275 serotonin uptake Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
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- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
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- 230000009870 specific binding Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
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- PVDVCPBPBAJWRA-UHFFFAOYSA-N tert-butyl 3-(2-oxochromen-6-yl)oxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound O1C(=O)C=CC2=CC(OC3CC4CCC(C3)N4C(=O)OC(C)(C)C)=CC=C21 PVDVCPBPBAJWRA-UHFFFAOYSA-N 0.000 description 1
- NCNPYLOTHHEKHP-UHFFFAOYSA-N tert-butyl bicyclo[3.2.1]octane-8-carboxylate Chemical compound C1CCC2CCC1C2C(=O)OC(C)(C)C NCNPYLOTHHEKHP-UHFFFAOYSA-N 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- KRIIYLYFQJZIEH-UHFFFAOYSA-N trichloromethyl 3-benzoyloxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical compound ClC(Cl)(Cl)OC(=O)N1C(C2)CCC1CC2OC(=O)C1=CC=CC=C1 KRIIYLYFQJZIEH-UHFFFAOYSA-N 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
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Classifications
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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Landscapes
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- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200600233 | 2006-02-17 | ||
| DKPA200600233 | 2006-02-17 | ||
| US77466906P | 2006-02-21 | 2006-02-21 | |
| US60/774,669 | 2006-02-21 | ||
| PCT/EP2007/051401 WO2007093604A1 (en) | 2006-02-17 | 2007-02-13 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2641916A1 true CA2641916A1 (en) | 2007-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002641916A Abandoned CA2641916A1 (en) | 2006-02-17 | 2007-02-13 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8153797B2 (enExample) |
| EP (2) | EP2311835A1 (enExample) |
| JP (1) | JP2009526816A (enExample) |
| KR (1) | KR20080096833A (enExample) |
| CN (1) | CN101405287B (enExample) |
| AR (1) | AR059546A1 (enExample) |
| AU (1) | AU2007216535A1 (enExample) |
| BR (1) | BRPI0707853A2 (enExample) |
| CA (1) | CA2641916A1 (enExample) |
| IL (1) | IL192485A0 (enExample) |
| NO (1) | NO20083955L (enExample) |
| RU (1) | RU2008129865A (enExample) |
| TW (1) | TW200800980A (enExample) |
| WO (1) | WO2007093604A1 (enExample) |
| ZA (1) | ZA200805908B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20110190T1 (hr) * | 2004-09-30 | 2011-04-30 | Neurosearch A/S | Novi derivati kromen-2-ona i njihova upotreba kao inhibitora povratnog unosa monoamina neurotransmitora |
| PL2121677T3 (pl) * | 2006-12-20 | 2011-04-29 | Neurosearch As | Nowe pochodne chromen-2-onu i ich zastosowanie jako inhibitorów wychwytu zwrotnego neurotransmiteru monoaminowego |
| US20090312364A1 (en) * | 2006-12-20 | 2009-12-17 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN102428083A (zh) * | 2009-05-15 | 2012-04-25 | 神经研究公司 | 色原烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| US20130040985A1 (en) | 2010-01-29 | 2013-02-14 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2011117289A1 (en) | 2010-03-25 | 2011-09-29 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors |
| WO2012000881A1 (en) | 2010-07-02 | 2012-01-05 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8923209D0 (en) * | 1989-10-14 | 1989-11-29 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| CZ285571B6 (cs) | 1995-11-02 | 1999-09-15 | Neurosearch A/S | Kondenzované tropanové deriváty, způsob jejich výroby, farmaceutické prostředky, které je obsahují a jejich použití k léčení |
| SK281813B6 (sk) | 1996-02-22 | 2001-08-06 | Neurosearch A/S | Tropánové deriváty, spôsob ich prípravy, použitie a farmaceutická kompozícia s ich obsahom |
| US5916914A (en) * | 1997-08-08 | 1999-06-29 | Warner-Lambert Company | Compounds and method of treating psychosis and schizophrenia |
| WO2002102801A1 (en) * | 2001-05-23 | 2002-12-27 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| MXPA04012440A (es) | 2002-06-12 | 2005-04-28 | Abbott Lab | Antagonistas de receptor de hormona concentradora de melanina. |
| US7538233B2 (en) | 2003-09-05 | 2009-05-26 | Aventis Pharmaceuticals Inc. | Coumarins as iNOS inhibitors |
| JP5001156B2 (ja) * | 2004-09-30 | 2012-08-15 | ノイロサーチ アクティーゼルスカブ | 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのその使用 |
| KR20070089170A (ko) | 2004-12-17 | 2007-08-30 | 뉴로서치 에이/에스 | 3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도 |
| PL2121677T3 (pl) | 2006-12-20 | 2011-04-29 | Neurosearch As | Nowe pochodne chromen-2-onu i ich zastosowanie jako inhibitorów wychwytu zwrotnego neurotransmiteru monoaminowego |
| US20090312364A1 (en) | 2006-12-20 | 2009-12-17 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
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2007
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- 2007-02-13 KR KR1020087022717A patent/KR20080096833A/ko not_active Withdrawn
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- 2007-02-13 ZA ZA200805908A patent/ZA200805908B/xx unknown
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2008
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Also Published As
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|---|---|
| CN101405287B (zh) | 2011-05-18 |
| AU2007216535A1 (en) | 2007-08-23 |
| JP2009526816A (ja) | 2009-07-23 |
| CN101405287A (zh) | 2009-04-08 |
| RU2008129865A (ru) | 2010-03-27 |
| IL192485A0 (en) | 2009-02-11 |
| BRPI0707853A2 (pt) | 2011-05-10 |
| ZA200805908B (en) | 2009-10-28 |
| EP2311835A1 (en) | 2011-04-20 |
| US8153797B2 (en) | 2012-04-10 |
| NO20083955L (no) | 2008-09-16 |
| EP1989202A1 (en) | 2008-11-12 |
| KR20080096833A (ko) | 2008-11-03 |
| AR059546A1 (es) | 2008-04-09 |
| EP1989202B1 (en) | 2012-07-25 |
| US20100227883A1 (en) | 2010-09-09 |
| TW200800980A (en) | 2008-01-01 |
| WO2007093604A1 (en) | 2007-08-23 |
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