CN101405287B - 色烯-2-酮衍生物和它们作为单胺神经递质再摄取抑制剂的用途 - Google Patents

色烯-2-酮衍生物和它们作为单胺神经递质再摄取抑制剂的用途 Download PDF

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Publication number
CN101405287B
CN101405287B CN2007800057510A CN200780005751A CN101405287B CN 101405287 B CN101405287 B CN 101405287B CN 2007800057510 A CN2007800057510 A CN 2007800057510A CN 200780005751 A CN200780005751 A CN 200780005751A CN 101405287 B CN101405287 B CN 101405287B
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chromen
disorder
aza
bicyclo
exo
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CN101405287A (zh
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D·彼得斯
J·P·雷德罗比
E·O·尼尔森
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NTG Nordic Transport Group AS
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Neurosearch AS
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    • C07—ORGANIC CHEMISTRY
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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CN2007800057510A 2006-02-17 2007-02-13 色烯-2-酮衍生物和它们作为单胺神经递质再摄取抑制剂的用途 Expired - Fee Related CN101405287B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200600233 2006-02-17
DKPA200600233 2006-02-17
PCT/EP2007/051401 WO2007093604A1 (en) 2006-02-17 2007-02-13 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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CN101405287A CN101405287A (zh) 2009-04-08
CN101405287B true CN101405287B (zh) 2011-05-18

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CN2007800057510A Expired - Fee Related CN101405287B (zh) 2006-02-17 2007-02-13 色烯-2-酮衍生物和它们作为单胺神经递质再摄取抑制剂的用途

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US (1) US8153797B2 (enExample)
EP (2) EP1989202B1 (enExample)
JP (1) JP2009526816A (enExample)
KR (1) KR20080096833A (enExample)
CN (1) CN101405287B (enExample)
AR (1) AR059546A1 (enExample)
AU (1) AU2007216535A1 (enExample)
BR (1) BRPI0707853A2 (enExample)
CA (1) CA2641916A1 (enExample)
IL (1) IL192485A0 (enExample)
NO (1) NO20083955L (enExample)
RU (1) RU2008129865A (enExample)
TW (1) TW200800980A (enExample)
WO (1) WO2007093604A1 (enExample)
ZA (1) ZA200805908B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007002384A (es) * 2004-09-30 2007-05-11 Neurosearch As Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina.
CA2673315A1 (en) * 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2007336291A1 (en) * 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2010247514A1 (en) 2009-05-15 2011-11-17 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en) 2010-01-29 2011-08-04 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en) 2010-03-25 2011-09-29 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en) 2010-07-02 2012-01-05 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1065661A (zh) * 1989-10-14 1992-10-28 约翰韦恩兄弟有限公司 杂环化合物的制备方法
EP1130020A1 (en) * 1996-02-22 2001-09-05 Neurosearch A/S Tropane-derivatives, their preparation and use
WO2002102801A1 (en) * 2001-05-23 2002-12-27 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ285571B6 (cs) 1995-11-02 1999-09-15 Neurosearch A/S Kondenzované tropanové deriváty, způsob jejich výroby, farmaceutické prostředky, které je obsahují a jejich použití k léčení
US5916914A (en) * 1997-08-08 1999-06-29 Warner-Lambert Company Compounds and method of treating psychosis and schizophrenia
JP2005532368A (ja) 2002-06-12 2005-10-27 アボット・ラボラトリーズ メラニン濃縮ホルモン受容体の拮抗薬
US7538233B2 (en) 2003-09-05 2009-05-26 Aventis Pharmaceuticals Inc. Coumarins as iNOS inhibitors
EP1797088B1 (en) * 2004-09-30 2011-01-05 NeuroSearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7781456B2 (en) 2004-12-17 2010-08-24 Neurosearch A/S Enantiomers of 3-heteroaryl-8H-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors
CA2673315A1 (en) 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2007336291A1 (en) 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1065661A (zh) * 1989-10-14 1992-10-28 约翰韦恩兄弟有限公司 杂环化合物的制备方法
EP1130020A1 (en) * 1996-02-22 2001-09-05 Neurosearch A/S Tropane-derivatives, their preparation and use
WO2002102801A1 (en) * 2001-05-23 2002-12-27 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Also Published As

Publication number Publication date
RU2008129865A (ru) 2010-03-27
EP1989202B1 (en) 2012-07-25
TW200800980A (en) 2008-01-01
AU2007216535A1 (en) 2007-08-23
EP2311835A1 (en) 2011-04-20
KR20080096833A (ko) 2008-11-03
US8153797B2 (en) 2012-04-10
EP1989202A1 (en) 2008-11-12
CA2641916A1 (en) 2007-08-23
ZA200805908B (en) 2009-10-28
BRPI0707853A2 (pt) 2011-05-10
IL192485A0 (en) 2009-02-11
AR059546A1 (es) 2008-04-09
WO2007093604A1 (en) 2007-08-23
JP2009526816A (ja) 2009-07-23
US20100227883A1 (en) 2010-09-09
CN101405287A (zh) 2009-04-08
NO20083955L (no) 2008-09-16

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