CA2637335A1 - Thiophene-carboxamides useful as inhibitors of protein kinases - Google Patents
Thiophene-carboxamides useful as inhibitors of protein kinases Download PDFInfo
- Publication number
- CA2637335A1 CA2637335A1 CA002637335A CA2637335A CA2637335A1 CA 2637335 A1 CA2637335 A1 CA 2637335A1 CA 002637335 A CA002637335 A CA 002637335A CA 2637335 A CA2637335 A CA 2637335A CA 2637335 A1 CA2637335 A1 CA 2637335A1
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Virology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
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| US76109706P | 2006-01-23 | 2006-01-23 | |
| US60/761,097 | 2006-01-23 | ||
| PCT/US2007/001726 WO2007087283A2 (en) | 2006-01-23 | 2007-01-23 | Thiophene-carboxamides useful as inhibitors of protein kinases |
Publications (1)
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| CA2637335A1 true CA2637335A1 (en) | 2007-08-02 |
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| EP (2) | EP2474546A1 (cg-RX-API-DMAC10.html) |
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| CN (1) | CN101400678A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007208358A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2637335A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007087283A2 (cg-RX-API-DMAC10.html) |
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| MX2008003173A (es) | 2005-09-06 | 2008-03-18 | Smithkline Beecham Corp | Compuestos de bencimidazol-tiofeno como inhibidores de plk. |
| EP2474546A1 (en) | 2006-01-23 | 2012-07-11 | Vertex Pharmaceuticals Inc. | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2007757B1 (en) * | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| CA2652816A1 (en) * | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
| PE20080710A1 (es) * | 2006-06-02 | 2008-08-07 | Smithkline Beecham Corp | Compuestos de tiofeno de bencimidazol |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| CN101711245B (zh) | 2007-07-19 | 2015-03-25 | H.隆德贝克有限公司 | 5元杂环酰胺及相关的化合物 |
| WO2010017046A1 (en) | 2008-08-05 | 2010-02-11 | Merck & Co., Inc. | Pyrazolo[1,5-a]pyridines as mark inhibitors |
| PH12012500778A1 (en) | 2009-10-30 | 2012-11-26 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| CA2803446C (en) | 2010-07-02 | 2019-06-04 | University Health Network | Use of plk4 antagonists for treating pten mutant diseases |
| JP6115962B2 (ja) | 2011-06-27 | 2017-04-19 | ヤンセン ファーマシューティカ エヌ．ベー． | １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体 |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| AU2013289284B2 (en) | 2012-07-09 | 2017-03-30 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
| EP3310360B1 (en) * | 2015-06-19 | 2024-03-27 | Beijing Artivila BioPharma Co. Ltd. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
| WO2018081719A1 (en) * | 2016-10-31 | 2018-05-03 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of nek2 and uses thereof |
| CN116057045B (zh) | 2020-06-05 | 2026-06-09 | 金耐特生物制药公司 | 成纤维细胞生长因子受体激酶抑制剂 |
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| IT1255802B (it) | 1992-08-07 | 1995-11-16 | Luso Farmaco Inst | Derivati imidazolici ad attivita' a ii antagonista |
| AU726058B2 (en) | 1995-09-01 | 2000-10-26 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| EP0922043B1 (en) | 1997-04-24 | 2002-01-30 | Dow AgroSciences LLC | Pesticidal 3-(substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazoles |
| DE19744026A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| PT957099E (pt) | 1998-04-15 | 2003-02-28 | Pfizer Prod Inc | Carboxamidas heterociclicas |
| CN1136218C (zh) | 1998-10-23 | 2004-01-28 | 道农业科学公司 | 制备3-(取代的苯基)-5-(噻吩基或呋喃基)-1,2,4-三唑的方法以及在其中使用的新中间体 |
| AU2001245401A1 (en) | 2000-03-01 | 2001-09-12 | Sumitomo Pharmaceuticals Company, Limited | Hydrazones and analogs as cholesterol lowering agents |
| US7273868B2 (en) | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
| US7041685B2 (en) | 2001-06-08 | 2006-05-09 | Cytovia, Inc. | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| AU2002356871A1 (en) | 2001-10-30 | 2003-05-12 | Pharmacia Corporation | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
| MXPA04000908A (es) | 2002-05-30 | 2004-03-26 | King Pharmaceuticals Res & Dev | Compuestos farmaceuticamente activos que tienen estructura de anillo de pirazolotriazolopirimidina triciclica y metodos de uso. |
| MXPA05001544A (es) * | 2002-08-08 | 2005-04-19 | Smithkline Beecham Corp | Compuestos de tiofeno. |
| JP2006516250A (ja) | 2002-12-18 | 2006-06-29 | サイトビア インコーポレイティッド | カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用 |
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| US20080293716A1 (en) | 2004-01-30 | 2008-11-27 | Smithkline Beecham Corporation | Chemical Compounds |
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| EP1924572B1 (en) * | 2005-09-06 | 2009-12-30 | SmithKline Beecham Corporation | Regioselective process for preparing benzimidazole thiophenes |
| EP2474546A1 (en) | 2006-01-23 | 2012-07-11 | Vertex Pharmaceuticals Inc. | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2007757B1 (en) | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| JP2009538305A (ja) | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
| CA2652816A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
-
2007
- 2007-01-23 EP EP11181807A patent/EP2474546A1/en not_active Withdrawn
- 2007-01-23 US US11/656,876 patent/US7915305B2/en not_active Expired - Fee Related
- 2007-01-23 AU AU2007208358A patent/AU2007208358A1/en not_active Abandoned
- 2007-01-23 WO PCT/US2007/001726 patent/WO2007087283A2/en not_active Ceased
- 2007-01-23 CA CA002637335A patent/CA2637335A1/en not_active Abandoned
- 2007-01-23 JP JP2008551474A patent/JP5498703B2/ja not_active Expired - Fee Related
- 2007-01-23 EP EP07762463A patent/EP1989205B1/en not_active Not-in-force
- 2007-01-23 CN CNA2007800088133A patent/CN101400678A/zh active Pending
-
2011
- 2011-02-24 US US13/033,872 patent/US8399478B2/en not_active Expired - Fee Related
-
2012
- 2012-12-25 JP JP2012281195A patent/JP2013056942A/ja active Pending
-
2013
- 2013-02-15 US US13/768,119 patent/US8759389B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2474546A1 (en) | 2012-07-11 |
| WO2007087283A2 (en) | 2007-08-02 |
| JP2013056942A (ja) | 2013-03-28 |
| AU2007208358A1 (en) | 2007-08-02 |
| US8399478B2 (en) | 2013-03-19 |
| EP1989205B1 (en) | 2012-06-13 |
| US20110288095A1 (en) | 2011-11-24 |
| EP1989205A2 (en) | 2008-11-12 |
| CN101400678A (zh) | 2009-04-01 |
| US8759389B1 (en) | 2014-06-24 |
| JP2009523822A (ja) | 2009-06-25 |
| US20070219205A1 (en) | 2007-09-20 |
| WO2007087283A3 (en) | 2007-09-13 |
| US7915305B2 (en) | 2011-03-29 |
| JP5498703B2 (ja) | 2014-05-21 |
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