PE20080710A1 - Compuestos de tiofeno de bencimidazol - Google Patents

Compuestos de tiofeno de bencimidazol

Info

Publication number
PE20080710A1
PE20080710A1 PE2007000666A PE2007000666A PE20080710A1 PE 20080710 A1 PE20080710 A1 PE 20080710A1 PE 2007000666 A PE2007000666 A PE 2007000666A PE 2007000666 A PE2007000666 A PE 2007000666A PE 20080710 A1 PE20080710 A1 PE 20080710A1
Authority
PE
Peru
Prior art keywords
alkyl
haloalkyl
halo
oxy
thiophenocarboxamide
Prior art date
Application number
PE2007000666A
Other languages
English (en)
Inventor
Kevin Kuntz
Kyle Allen Emmitte
Tara Renae Rheault
Stephon Smith
Keith Hornberger
Hamilton Dickson
Mui Cheung
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20080710A1 publication Critical patent/PE20080710A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A COMPUESTOS TIOFENO DE BENCIMIDAZOL DE FORMULA (I), EN DONDE R1 ES H, HALO, ALQUILO, ENTRE OTROS; R2 ES H, HALO, ALQUILO, ENTRE OTROS; R3 ES H, ALQUILO O HALOALQUILO; Z1, Z2 y Z3 SON INDEPENDIENTEMENTE C, CH O N, EN DONDE AL MENOS UNO ES C O CH; d ES 0,1 o 2; R4 ES HALO, ALQUILO O HALOALQUILO; Y1 ES -O- o -N(R7)-; a ES 0 o 1; R5 ES ALQUILENO(C1-C3); ANILLO A ES HETEROCICLO DE 5 A 6 MIEMBROS CON 1 O 2 HETEROATOMOS SELECCIONADOS DE N, O y S; b ES 0, 1 0 2; R6 ES HALO, ALQUILO, HALOALQUILO, ENTRE OTROS; R7 ES H, ALQUILO, HALOALQUILO, ENTRE OTROS. SON SELECCIONADOS: 5-[5,6-BIS(METILOXI)-1H-BENCIMIDAZOL-1-IL]-3-[((1R)-1-{2-CLORO-3-[(4-PIPERIDINILMETIL)AMINO]FENIL}ETIL)OXI]-2-TIOFENOCARBOXAMIDA, 5-[5,6-BIS(METILOXI)-1H-BENCIMIDAZOL-1-IL]-3-{[(1R)-1-{2-CLORO-3-{[(1-METIL-4-PIPERIDINIL)METIL]OXI}FENIL)ETIL]OXI}-2-TIOFENOCARBOXAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASAS SIMILARES A POLO (PLK1), SIENDO UTILES EN TRATAMIENTO DE CANCER DE MAMA, DE OVARIO, DE PULMON, DE PROSTATA, LEUCEMIAS AGUDAS Y ENFERMEDADES MEDIADAS POR EL PLK
PE2007000666A 2006-06-02 2007-05-29 Compuestos de tiofeno de bencimidazol PE20080710A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81052606P 2006-06-02 2006-06-02

Publications (1)

Publication Number Publication Date
PE20080710A1 true PE20080710A1 (es) 2008-08-07

Family

ID=38657232

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000666A PE20080710A1 (es) 2006-06-02 2007-05-29 Compuestos de tiofeno de bencimidazol

Country Status (9)

Country Link
US (1) US20100075960A1 (es)
EP (1) EP2032563B1 (es)
JP (1) JP2009539770A (es)
AR (1) AR060979A1 (es)
AT (1) ATE469894T1 (es)
DE (1) DE602007006950D1 (es)
PE (1) PE20080710A1 (es)
TW (1) TW200808756A (es)
WO (1) WO2007143456A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ566345A (en) * 2005-09-06 2010-04-30 Smithkline Beecham Corp Benzimidazole thiophene compounds as PLK inhibitors
MX2011007399A (es) * 2009-01-09 2011-11-18 Panacea Biotec Ltd Suspension farmaceutica de liberacion doble.
CN112020500A (zh) 2017-12-22 2020-12-01 拉文纳制药公司 作为磷脂酰肌醇磷酸激酶抑制剂的氨基吡啶衍生物
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
EP3997088A4 (en) * 2019-07-10 2022-12-28 Aucentra Therapeutics Pty Ltd DERIVATIVES OF 4-(IMIDAZO[L,2-A]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2493908A1 (en) * 2002-08-08 2004-02-19 Smithkline Beecham Corporation Thiophene compounds
JP2007509070A (ja) * 2003-10-16 2007-04-12 スミスクライン ビーチャム コーポレーション チオフェン化合物
GB0402809D0 (en) * 2004-02-09 2004-03-10 Glaxo Group Ltd Chemical compounds
NZ566345A (en) * 2005-09-06 2010-04-30 Smithkline Beecham Corp Benzimidazole thiophene compounds as PLK inhibitors
US20080214563A1 (en) * 2005-09-06 2008-09-04 Mui Cheung Benzimidazole Thiophene Compounds As Plk Modulators
CA2637335A1 (en) * 2006-01-23 2007-08-02 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
US7615643B2 (en) * 2006-06-02 2009-11-10 Smithkline Beecham Corporation Benzimidazole thiophene compounds

Also Published As

Publication number Publication date
WO2007143456A2 (en) 2007-12-13
TW200808756A (en) 2008-02-16
AR060979A1 (es) 2008-07-23
EP2032563A2 (en) 2009-03-11
ATE469894T1 (de) 2010-06-15
WO2007143456A3 (en) 2008-02-14
EP2032563B1 (en) 2010-06-02
JP2009539770A (ja) 2009-11-19
DE602007006950D1 (de) 2010-07-15
US20100075960A1 (en) 2010-03-25

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Legal Events

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