ATE469894T1 - Benzimidazol-substituierte thiophenderivate mit wirkung auf plk - Google Patents

Benzimidazol-substituierte thiophenderivate mit wirkung auf plk

Info

Publication number
ATE469894T1
ATE469894T1 AT07797838T AT07797838T ATE469894T1 AT E469894 T1 ATE469894 T1 AT E469894T1 AT 07797838 T AT07797838 T AT 07797838T AT 07797838 T AT07797838 T AT 07797838T AT E469894 T1 ATE469894 T1 AT E469894T1
Authority
AT
Austria
Prior art keywords
plk
benzimidazole
substituted thiophene
thiophene derivatives
derivatives acting
Prior art date
Application number
AT07797838T
Other languages
English (en)
Inventor
Kevin Kuntz
Kyle Allen Emmitte
Tara Renae Rheault
Stephon Smith
Keith Hornberger
Hamilton Dickson
Mui Cheung
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Application granted granted Critical
Publication of ATE469894T1 publication Critical patent/ATE469894T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT07797838T 2006-06-02 2007-05-29 Benzimidazol-substituierte thiophenderivate mit wirkung auf plk ATE469894T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81052606P 2006-06-02 2006-06-02
PCT/US2007/069879 WO2007143456A2 (en) 2006-06-02 2007-05-29 Benzimidazol substituted thiophene derivatives with activity on plk

Publications (1)

Publication Number Publication Date
ATE469894T1 true ATE469894T1 (de) 2010-06-15

Family

ID=38657232

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07797838T ATE469894T1 (de) 2006-06-02 2007-05-29 Benzimidazol-substituierte thiophenderivate mit wirkung auf plk

Country Status (9)

Country Link
US (1) US20100075960A1 (de)
EP (1) EP2032563B1 (de)
JP (1) JP2009539770A (de)
AR (1) AR060979A1 (de)
AT (1) ATE469894T1 (de)
DE (1) DE602007006950D1 (de)
PE (1) PE20080710A1 (de)
TW (1) TW200808756A (de)
WO (1) WO2007143456A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR055616A1 (es) * 2005-09-06 2007-08-29 Smithkline Beecham Corp Compuestos de tiofeno bencimidazol
US20110268808A1 (en) * 2009-01-09 2011-11-03 Panacea Biotec Ltd. Dual-release pharmaceutical suspension
RU2020124138A (ru) 2017-12-22 2022-01-24 Хиберселл, Инк. Производные аминопиридина в качестве ингибиторов фосфатидилинозитолфосфаткиназы
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
CN114269742A (zh) * 2019-07-10 2022-04-01 常州千红生化制药股份有限公司 作为治疗剂的4-(咪唑并[1,2-a]吡啶-3-基)-N-(吡啶基)嘧啶-2-胺的衍生物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2296758C2 (ru) * 2002-08-08 2007-04-10 Смитклайн Бичем Корпорейшн Производные тиофена
EP1685128A1 (de) * 2003-10-16 2006-08-02 Smithkline Beecham Corporation Verfahren zur herstellung von benzimidazolthiophenen
GB0402809D0 (en) * 2004-02-09 2004-03-10 Glaxo Group Ltd Chemical compounds
WO2007030359A1 (en) * 2005-09-06 2007-03-15 Smithkline Beecham Corporation Benzimidazole thiophene compounds as plk modulators
AR055616A1 (es) * 2005-09-06 2007-08-29 Smithkline Beecham Corp Compuestos de tiofeno bencimidazol
CA2637335A1 (en) * 2006-01-23 2007-08-02 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
US7615643B2 (en) * 2006-06-02 2009-11-10 Smithkline Beecham Corporation Benzimidazole thiophene compounds

Also Published As

Publication number Publication date
JP2009539770A (ja) 2009-11-19
PE20080710A1 (es) 2008-08-07
WO2007143456A2 (en) 2007-12-13
AR060979A1 (es) 2008-07-23
EP2032563B1 (de) 2010-06-02
DE602007006950D1 (de) 2010-07-15
EP2032563A2 (de) 2009-03-11
US20100075960A1 (en) 2010-03-25
WO2007143456A3 (en) 2008-02-14
TW200808756A (en) 2008-02-16

Similar Documents

Publication Publication Date Title
DE602008001431D1 (de) Lösliche Polythiophenderivate
DK1863787T3 (da) Hydrogeneret benzo[c]thiophenderivater som immunmodulatorer
DK2016080T3 (da) Dihydropyrazolopyrimidinon-derivater
ATE483711T1 (de) Spiroindolinonderivate
DE602007013341D1 (de) Phasenwechseltinten
DE602007010592D1 (de) Kinasehemmer auf hydantoinbasis
ATE469905T1 (de) Pyridopyrimidinonderivate
ATE512135T1 (de) Spiroindolinonderivate
DK2351747T3 (da) Fungicide N-cycloalkylbenzylamidderivater
BRPI1012770A2 (pt) derivados de tiofeno
DK2035394T3 (da) 2-pyrazincarboxamidderivater
ZA200711147B (en) Novel thiophene derivatives
IL186149A0 (en) Novel thiophene derivatives
ZA200805407B (en) Novel thiophene derivatives
BRPI0716193A2 (pt) Replicon derivado de potexvírus
BRPI0811718A2 (pt) Derivados de 3,3-espiroindolinona
DE602007014221D1 (de) Chromenverbindung
BRPI0720220A2 (pt) Derivados de quinolinas antibacterianos
DE602008005634D1 (de) 1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
BRPI0817579A2 (pt) Derivados de tiazol
ATE544764T1 (de) 5-hydroxymethyloxazolidin-2-onderivate
FR2902426B1 (fr) Derives de cinnamoyl-piperazine
DE102004061746A8 (de) Alkinyl-substituierte Thiophene
BRPI0812107A2 (pt) Formulação de duloxetina
ITPN20060088A1 (it) Cavaturaccioli a scatto

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties