CA2634915A1 - Chlorite formulations, and methods of preparation and use thereof - Google Patents
Chlorite formulations, and methods of preparation and use thereof Download PDFInfo
- Publication number
- CA2634915A1 CA2634915A1 CA002634915A CA2634915A CA2634915A1 CA 2634915 A1 CA2634915 A1 CA 2634915A1 CA 002634915 A CA002634915 A CA 002634915A CA 2634915 A CA2634915 A CA 2634915A CA 2634915 A1 CA2634915 A1 CA 2634915A1
- Authority
- CA
- Canada
- Prior art keywords
- chlorite
- formulation
- variations
- formulations
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229910001919 chlorite Inorganic materials 0.000 title claims abstract description 508
- 229910052619 chlorite group Inorganic materials 0.000 title claims abstract description 508
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 title claims abstract description 507
- 239000000203 mixture Substances 0.000 title claims abstract description 455
- 238000009472 formulation Methods 0.000 title claims abstract description 394
- 238000000034 method Methods 0.000 title claims abstract description 145
- 238000002360 preparation method Methods 0.000 title description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 83
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 claims description 115
- 239000000243 solution Substances 0.000 claims description 77
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 50
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 46
- 239000003002 pH adjusting agent Substances 0.000 claims description 46
- 201000010099 disease Diseases 0.000 claims description 42
- 239000003125 aqueous solvent Substances 0.000 claims description 40
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 39
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 35
- 231100000419 toxicity Toxicity 0.000 claims description 34
- 230000001988 toxicity Effects 0.000 claims description 34
- 238000001914 filtration Methods 0.000 claims description 33
- VOWOEBADKMXUBU-UHFFFAOYSA-J molecular oxygen;tetrachlorite;hydrate Chemical compound O.O=O.[O-]Cl=O.[O-]Cl=O.[O-]Cl=O.[O-]Cl=O VOWOEBADKMXUBU-UHFFFAOYSA-J 0.000 claims description 32
- 239000012535 impurity Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
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- 239000007787 solid Substances 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 28
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 25
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims description 19
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- 230000008025 crystallization Effects 0.000 claims description 14
- 239000001488 sodium phosphate Substances 0.000 claims description 14
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- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 13
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 13
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical group [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 12
- 239000010452 phosphate Substances 0.000 claims description 12
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- 235000019398 chlorine dioxide Nutrition 0.000 claims description 10
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
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- 206010018338 Glioma Diseases 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B11/00—Oxides or oxyacids of halogens; Salts thereof
- C01B11/08—Chlorous acid
- C01B11/10—Chlorites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2919344A CA2919344C (en) | 2005-12-22 | 2006-12-21 | Chlorite formulations, and methods of preparation and use thereof |
Applications Claiming Priority (3)
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| US75349705P | 2005-12-22 | 2005-12-22 | |
| US60/753,497 | 2005-12-22 | ||
| PCT/US2006/048941 WO2007075972A2 (en) | 2005-12-22 | 2006-12-21 | Chlorite formulations, and methods of preparation and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2919344A Division CA2919344C (en) | 2005-12-22 | 2006-12-21 | Chlorite formulations, and methods of preparation and use thereof |
Publications (1)
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| CA2634915A1 true CA2634915A1 (en) | 2007-07-05 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012106822A1 (en) * | 2011-02-09 | 2012-08-16 | Nuvo Research Ag. | Wound dressings comprising chlorite |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110027330A1 (en) * | 2005-03-01 | 2011-02-03 | Martin Roy W | Tablet composition for the in-situ generation of chlorine dioxide for use in antimicrobial applications |
| US8067035B2 (en) | 2005-12-22 | 2011-11-29 | Neuraltus Pharmaceuticals, Inc. | Chlorite formulations, and methods of preparation and use thereof |
| CA2689075A1 (en) * | 2007-06-01 | 2008-12-04 | Dimethaid Ag | Use of wf10 for treating allergic asthma, allergic rhinitis and atopic dermatitis |
| AU2010281524A1 (en) | 2009-08-06 | 2012-02-23 | Neuraltus Pharmaceuticals, Inc. | Treatment of macrophage-related disorders |
| CN103189049A (zh) * | 2010-08-13 | 2013-07-03 | 努沃研究公司 | 稳定的亚氯酸盐的可发泡组合物 |
| FR2968559B1 (fr) * | 2010-12-14 | 2012-12-28 | Alexandra Fregonese | Nouvelles compositions a base d'argile et de beepollen, leur procede de preparation et leurs utilisations en nutrition et en therapeutique |
| DE102010055771A1 (de) * | 2010-12-23 | 2012-06-28 | KyroChem GmbH | Chlorithaltige Zusammensetzung |
| US9381214B2 (en) | 2011-03-18 | 2016-07-05 | Puricore, Inc. | Methods for treating skin irritation |
| CN104125826A (zh) | 2011-12-22 | 2014-10-29 | 努沃研究有限责任公司 | 亚氯酸盐或氯酸盐脂质体组合物 |
| EP2804612A4 (en) * | 2012-01-19 | 2015-09-02 | Ibt Pharma Inc | THERAPEUTIC USES OF TETRACHLORODECAOXYGEN (TCDO) |
| JP2015071581A (ja) * | 2013-05-20 | 2015-04-16 | 本部三慶株式会社 | 亜塩素酸水含有ウイルス殺傷剤 |
| JP6800014B2 (ja) * | 2013-10-03 | 2020-12-16 | ユミコア・アクチエンゲゼルシャフト・ウント・コムパニー・コマンディットゲゼルシャフトＵｍｉｃｏｒｅ ＡＧ ＆ Ｃｏ．ＫＧ | 排気後処理システム |
| WO2015181800A2 (en) * | 2014-05-30 | 2015-12-03 | Nuvo Research Ag | Methods for purifying chlorites and chlorates |
| WO2017079161A2 (en) | 2015-11-02 | 2017-05-11 | Neuraltus Pharmaceuticals, Inc. | Treatment of neurodegenerative disease with sodium chlorite |
| DE102016007081A1 (de) * | 2016-06-10 | 2017-12-14 | Alethia Life Sciences Ag | Chlordioxid Desinfektionstuch |
| EP4147703A4 (en) * | 2020-05-21 | 2023-11-08 | Osaka University | Epithelial cancer therapeutic agent |
| CA3233863A1 (en) * | 2021-10-04 | 2023-04-13 | Arasteh AZHIR | Treatment methods for als patients |
| JP2025518546A (ja) | 2022-05-19 | 2025-06-17 | ニューヴィヴォ， インコーポレイテッド | 神経変性疾患のバイオマーカー |
| US20240367988A1 (en) * | 2023-04-20 | 2024-11-07 | Neuvivo, Inc. | Chlorite compositions |
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| US2129464A (en) * | 1937-10-06 | 1938-09-06 | Mathieson Alkali Works Inc | Recovery of sodium chloride and sodium chlorite from aqueous solutions |
| US2169066A (en) * | 1938-07-01 | 1939-08-08 | Mathieson Alkali Works Inc | Preparation of sodium chlorate and sodium chlorite and the separation thereof |
| DE941665C (de) * | 1951-04-19 | 1956-04-19 | Val Mehler Segeltuchweberei Ag | Verfahren zum Bleichen von Textilien |
| US3082146A (en) | 1959-02-04 | 1963-03-19 | Chemical Res Lab Of America In | Process for the treatment of water |
| US4296103A (en) | 1980-08-08 | 1981-10-20 | Felipe Laso | Stabilized solution of chlorine oxides |
| DE3213389A1 (de) * | 1982-04-10 | 1983-10-20 | Friedrich-Wilhelm Dr. 7107 Neckarsulm Kühne | Stabilisierter aktivierter sauerstoff und arzneimittel, die diesen stabilisierten aktivierten sauerstoff enthalten |
| DE3515745A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Waessrige chloritmatrix-loesung |
| DE3515749A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Verwendung einer stabilisierten chloritmatrixloesung bei infektioesen zustaenden |
| DE3515748A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Verwendung einer isotonen chloritmatrix-loesung bei der behandlung von tumoren |
| US4944920A (en) | 1986-08-01 | 1990-07-31 | University Of Southern California | Novel method to treat blood |
| US4851222A (en) | 1988-01-27 | 1989-07-25 | Oxo Chemie Gmbh | Method of promoting regeneration of bone marrow |
| US5078908A (en) * | 1989-10-02 | 1992-01-07 | Allergan, Inc. | Methods for generating chlorine dioxide and compositions for disinfecting |
| DE4208828A1 (de) * | 1992-03-19 | 1993-09-23 | Oxo Chemie Gmbh | Verwendung einer chemisch stabilisierten chloritmatrix zur herstellung von arzneimitteln zur behandlung von hiv-infektionen |
| US5622725A (en) * | 1992-03-20 | 1997-04-22 | Alcide Corporation | Wound disinfection and repair |
| GB9208731D0 (en) * | 1992-04-22 | 1992-06-10 | Squibb & Sons Inc | Hydrocolloid wound gel |
| US6099855A (en) | 1992-06-25 | 2000-08-08 | Bioxy, Inc. | Therapeutic, production and immunostimulatory uses of biocidal compositions |
| US5830511A (en) * | 1992-06-25 | 1998-11-03 | Bioxy Inc. | Therapeutic, production and immunostimulatory uses of biocidal compositions |
| CA2152077A1 (en) * | 1992-12-17 | 1994-06-23 | Anthony P. Frangione | Contact lens disinfecting solution containing sodium chlorite and polyvinyl pyrrolidone |
| JPH06230717A (ja) | 1993-02-02 | 1994-08-19 | Kanebo Ltd | 骨模型 |
| US5639295A (en) * | 1995-06-05 | 1997-06-17 | Southwest Research Institute | Method of making a composition containing a stable chlorite source |
| US5489435A (en) * | 1993-07-06 | 1996-02-06 | Ratcliff; Perry A. | Composition for treatment of abnormal conditions of the epithelium of bodily orifices |
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| US5723095A (en) * | 1995-12-28 | 1998-03-03 | Steris Corporation | Cleaner concentrate formulation for biological waste fluid handling systems |
| US5877222A (en) * | 1996-07-19 | 1999-03-02 | The Regents Of The University Of California | Method for treating aids-associated dementia |
| WO1999017787A2 (en) | 1997-10-06 | 1999-04-15 | Oxo Chemie Ag | Use of a chemically-stabilized chlorite solution for inhibiting an antigen-specific immune response |
| US6350438B1 (en) | 1998-02-27 | 2002-02-26 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| US6132702A (en) * | 1998-02-27 | 2000-10-17 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| DE69923987T2 (de) * | 1998-10-08 | 2006-11-02 | Karagoezian, Hampar L., San Juan Capistrano | Synergistische antimikrobielle, dermatologische und ophtahalmologische zubereitung, die ein chlorit und wasserstoffperoxid enthalten |
| US20040037891A1 (en) * | 1999-10-04 | 2004-02-26 | Karagoezian Hampar L. | Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide |
| US20040224306A1 (en) * | 1999-11-30 | 2004-11-11 | Frederich-Wilhelm Kuhne | Evaluating and predicting clinical outcomes by gene expression analysis |
| DE10012340A1 (de) * | 2000-03-14 | 2001-09-20 | Merck Patent Gmbh | Verfahren zur Baeyer-Villiger-Oxidation organischer Carbonylverbindungen |
| EP1370715A1 (en) * | 2001-01-16 | 2003-12-17 | KELLEY, Joseph Matthew | An electrolytic process for the generation of stable solutions of chlorine dioxide |
| AU2002311922A1 (en) * | 2001-05-15 | 2002-11-25 | The Procter And Gamble Company | Oral care compositions |
| ITMI20011702A1 (it) * | 2001-08-03 | 2003-02-03 | Acraf | Soluzione disinfettante a base di ipoclorito di sodio e procedimento per prepararla |
| AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| US8067035B2 (en) | 2005-12-22 | 2011-11-29 | Neuraltus Pharmaceuticals, Inc. | Chlorite formulations, and methods of preparation and use thereof |
| WO2016038678A1 (ja) | 2014-09-09 | 2016-03-17 | 三菱電機株式会社 | エレベータの機器取付装置 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012106822A1 (en) * | 2011-02-09 | 2012-08-16 | Nuvo Research Ag. | Wound dressings comprising chlorite |
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| EP1979269A4 (en) | 2013-01-02 |
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