CA2629936A1 - Biocompatible surgical compositions - Google Patents

Biocompatible surgical compositions Download PDF

Info

Publication number
CA2629936A1
CA2629936A1 CA002629936A CA2629936A CA2629936A1 CA 2629936 A1 CA2629936 A1 CA 2629936A1 CA 002629936 A CA002629936 A CA 002629936A CA 2629936 A CA2629936 A CA 2629936A CA 2629936 A1 CA2629936 A1 CA 2629936A1
Authority
CA
Canada
Prior art keywords
composition
diamine
isocyanate
functional
polyalkylene oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002629936A
Other languages
English (en)
French (fr)
Inventor
Nadya Belcheva
Ahmad R. Hadba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covidien LP
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2629936A1 publication Critical patent/CA2629936A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/721—Two or more polyisocyanates not provided for in one single group C08G18/73 - C08G18/80
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/2805—Compounds having only one group containing active hydrogen
    • C08G18/2815—Monohydroxy compounds
    • C08G18/283—Compounds containing ether groups, e.g. oxyalkylated monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C08G18/3225—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/50—Polyethers having heteroatoms other than oxygen
    • C08G18/5021—Polyethers having heteroatoms other than oxygen having nitrogen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J175/00—Adhesives based on polyureas or polyurethanes; Adhesives based on derivatives of such polymers
    • C09J175/04—Polyurethanes
    • C09J175/08—Polyurethanes from polyethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2190/00—Compositions for sealing or packing joints
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials For Medical Uses (AREA)
  • Polyurethanes Or Polyureas (AREA)
CA002629936A 2005-12-08 2006-12-08 Biocompatible surgical compositions Abandoned CA2629936A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74839405P 2005-12-08 2005-12-08
US60/748,394 2005-12-08
PCT/US2006/047023 WO2007067764A2 (en) 2005-12-08 2006-12-08 Biocompatible surgical compositions

Publications (1)

Publication Number Publication Date
CA2629936A1 true CA2629936A1 (en) 2007-06-14

Family

ID=38123542

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002629936A Abandoned CA2629936A1 (en) 2005-12-08 2006-12-08 Biocompatible surgical compositions

Country Status (6)

Country Link
US (1) US20070135606A1 (https=)
EP (1) EP1960446A4 (https=)
JP (1) JP2009518138A (https=)
AU (1) AU2006321856B2 (https=)
CA (1) CA2629936A1 (https=)
WO (1) WO2007067764A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1962867B1 (en) * 2005-12-06 2013-06-19 Covidien LP Biocompatible surgical compositions
WO2007067625A2 (en) 2005-12-06 2007-06-14 Tyco Healthcare Group Lp Bioabsorbable surgical composition
WO2007067624A2 (en) * 2005-12-06 2007-06-14 Tyco Healthcare Group Lp Bioabsorbable compounds and compositions containing them
JP2009518142A (ja) * 2005-12-08 2009-05-07 タイコ ヘルスケア グループ リミテッド パートナーシップ 生体適合性外科用組成物
US7858835B2 (en) * 2007-06-27 2010-12-28 Tyco Healthcare Group Lp Foam control for synthetic adhesive/sealant
US8500947B2 (en) * 2007-11-15 2013-08-06 Covidien Lp Speeding cure rate of bioadhesives
US8263704B2 (en) * 2008-04-23 2012-09-11 Tyco Healthcare Group Lp Bioabsorbable surgical composition
US9554888B2 (en) * 2010-04-20 2017-01-31 University Of Utah Research Foundation Phase separation sprayed scaffold
US20130331537A1 (en) * 2012-06-08 2013-12-12 Poly-Med, Inc. Polyether urethane and polyether urea based copolymers and methods related thereto
US10016454B2 (en) * 2012-12-04 2018-07-10 Cohera Medical, Inc. Silane-containing moisture-curable tissue sealant

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2032297A1 (de) * 1970-06-23 1971-12-30 Schering Ag Verfahren zum Verkleben von weichgemachten, chlorhaltigen Polymerisaten
US3879493A (en) * 1972-02-14 1975-04-22 Cpc International Inc Vapor permeable compositions
JPS5010826A (https=) * 1973-06-02 1975-02-04
US3903232A (en) * 1973-10-09 1975-09-02 Grace W R & Co Dental and biomedical foams and method
US3975550A (en) * 1974-08-07 1976-08-17 General Foods Corporation Plastically deformable ready-to-use batter
US4057535A (en) * 1976-04-14 1977-11-08 Tatyana Esperovna Lipatova Adhesive for gluing together soft body tissues
US4169175A (en) * 1976-06-14 1979-09-25 W. R. Grace & Co. Removal of unreacted tolylene diisocyanate from urethane prepolymers
US4132839A (en) * 1976-10-12 1979-01-02 W. R. Grace & Co. Biodegradable hydrophilic foams and method
SE417975B (sv) * 1977-09-20 1981-04-27 Gambro Dialysatoren Forfarande for katalytisk utherdning av polyuretanformmassor i vilket man sasom fysiologiskt fordragbar herdningskatalysator anvender sorbinsyra eller kanelsyra
US4323491A (en) * 1980-04-24 1982-04-06 Veselovsky Roman A Polyurethane adhesive composition
AU558611B2 (en) * 1981-02-03 1987-02-05 Bayer Aktiengesellschaft Polyurethane gel
US4425472A (en) * 1981-06-22 1984-01-10 Lord Corporation Radiation-curable compositions
US4451627A (en) * 1982-09-07 1984-05-29 The Dow Chemical Company Addition polymerizable urethane-based anaerobic adhesives made from tin (II) organoesters
US4511626A (en) * 1982-09-09 1985-04-16 Minnesota Mining And Manufacturing Company One-part moisture-curable polyurethane adhesive, coating, and sealant compositions
US4477604A (en) * 1982-09-20 1984-10-16 Oechsle Iii Sixtus J Polyurethane compositions and their use as luting agents
DE3329392A1 (de) * 1983-08-13 1985-02-28 Bayer Ag, 5090 Leverkusen Thermisch verformbares konstruktionsmaterial, verfahren zu dessen herstellung und dessen verwendung
JPS6058156A (ja) * 1983-09-08 1985-04-04 三洋化成工業株式会社 シ−ル材および人工臓器
JPS60152535A (ja) * 1984-01-20 1985-08-10 Ichiro Shibauchi 架橋剤及びその製造方法
JPS6147775A (ja) * 1984-08-14 1986-03-08 Dainippon Ink & Chem Inc 複合ラミネ−トフイルム用接着剤組成物
JPS61152765A (ja) * 1984-12-27 1986-07-11 Nippon Ekishiyou Kk シクロデキストリン類で包接された化合物を含有した合成樹脂製品及びその製造方法
US4740534A (en) * 1985-08-30 1988-04-26 Sanyo Chemical Industries, Ltd. Surgical adhesive
ES2043619T3 (es) * 1986-05-14 1994-01-01 Takiron Co Adhesivo para administracion percutanea.
JPH0739457B2 (ja) * 1986-05-14 1995-05-01 タキロン株式会社 両親媒性セグメントポリウレタン
US5082663A (en) * 1986-08-20 1992-01-21 Teikoku Seiyaky Co., Ltd. External adhesive preparation containing steroids
GB8629231D0 (en) * 1986-12-06 1987-01-14 Smith & Nephew Ass Adhesive & dressings
US4829099A (en) * 1987-07-17 1989-05-09 Bioresearch, Inc. Metabolically acceptable polyisocyanate adhesives
US4804691A (en) * 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
GB8720440D0 (en) * 1987-08-28 1987-10-07 Smith & Nephew Ass Curable compositions
JP2691722B2 (ja) * 1988-03-07 1997-12-17 旭硝子株式会社 外科用接着剤
US5065752A (en) * 1988-03-29 1991-11-19 Ferris Mfg. Co. Hydrophilic foam compositions
US4883837A (en) * 1988-06-24 1989-11-28 The Dow Chemical Company Compatible blends of polyolefins with thermoplastic polyurethanes
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
EP0390481B1 (en) * 1989-03-23 1996-02-28 Sanyo Chemical Industries Ltd. Surgical adhesive sheet
US4994208A (en) * 1989-04-18 1991-02-19 Ppg Industries, Inc. Photochromic polymeric article
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5204110A (en) * 1990-05-02 1993-04-20 Ndm Acquisition Corp. High absorbency hydrogel wound dressing
US5389718A (en) * 1990-07-30 1995-02-14 Miles Inc. Two-component aqueous polyurethane dispersions
CA2083741A1 (en) * 1992-01-24 1993-07-25 James Anthony Braatz Protein nonadsorptive membranes for wound dressings
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5346981A (en) * 1993-01-13 1994-09-13 Miles Inc. Radiopaque polyurethanes
GB9306887D0 (en) * 1993-04-01 1993-05-26 Graham Neil B Random block copolymers
JPH09511666A (ja) * 1994-04-08 1997-11-25 アトリックス・ラボラトリーズ・インコーポレイテッド 医療装置で使用する付随的ポリマー系
JP2959399B2 (ja) * 1994-06-13 1999-10-06 日本ポリウレタン工業株式会社 自己乳化型ポリイソシアネート混合物、並びにこれを用いた水性塗料組成物および水性接着剤組成物
DE69513831T2 (de) * 1994-07-04 2000-07-27 Asahi Kasei Kogyo K.K., Osaka Semicarbazid-derivate und diese enthaltende coatings
US5795633A (en) * 1994-08-22 1998-08-18 Nippon Zeon Co., Ltd. Material composition and shaped article
BR9607155A (pt) * 1995-01-13 1997-11-11 Essex Specialty Prod Composição adesiva bicomponente processo para ligar dois substratos entre si
US5618850A (en) * 1995-03-09 1997-04-08 Focal, Inc. Hydroxy-acid cosmetics
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5780573A (en) * 1995-06-13 1998-07-14 Kuraray Co., Ltd. Thermoplastic polyurethanes and molded articles comprising them
US5652300A (en) * 1995-12-11 1997-07-29 Nippon Polyurethane Industry Co., Ltd. Self-emulsifiable polyisocyanate mixture and aqueous coating or adhesive compostion comprising the mixture
US6103850A (en) * 1995-12-29 2000-08-15 Basf Corporation Sealants made using low unsaturation polyoxyalkylene polyether polyols
US5922809A (en) * 1996-01-11 1999-07-13 The Dow Chemical Company One-part moisture curable polyurethane adhesive
US5948427A (en) * 1996-04-25 1999-09-07 Point Medical Corporation Microparticulate surgical adhesive
DE19624641A1 (de) * 1996-06-20 1998-01-08 Biotec Biolog Naturverpack Biologisch abbaubarer Werkstoff, bestehend im wesentlichen aus oder auf Basis thermoplastischer Stärke
US5807944A (en) * 1996-06-27 1998-09-15 Ciba Vision Corporation Amphiphilic, segmented copolymer of controlled morphology and ophthalmic devices including contact lenses made therefrom
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US20020039594A1 (en) * 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US5900473A (en) * 1997-06-16 1999-05-04 H.B. Fuller Licensing & Financing, Inc. Radiation curable pressure sensitive adhesives
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US6043313A (en) * 1997-09-04 2000-03-28 Eastman Chemical Company Thermoplastic polyurethane additives for improved polymer matrix composites and methods of making and using therefor
US5869566A (en) * 1997-09-24 1999-02-09 Ppg Industries, Inc. Rapid drying, isocyanate cured coating composition with improved adhesion
EP1068252B1 (en) * 1998-03-31 2005-11-23 Sekisui Chemical Co., Ltd. Polyesterurethane elastomers and process for their production
JP4132244B2 (ja) * 1998-07-06 2008-08-13 株式会社クラレ 熱可塑性ポリウレタンからなるポリウレタン弾性繊維およびその製造方法
US6297349B1 (en) * 1998-08-25 2001-10-02 Union Carbide Chemicals & Plastics Technology Corporation Condensation copolymers having supressed crystallinity
JP2002531217A (ja) * 1998-12-04 2002-09-24 チャンドラシェカー ピー． パサック， 生体適合性架橋ポリマー
ATE264898T1 (de) * 1999-02-05 2004-05-15 Essex Specialty Prod Polyurethandichtungszusammensetzung
DE19924092A1 (de) * 1999-05-26 2000-11-30 Bayer Ag Adhäsionsstabiles Verbundmaterial aus Polyurethan und einem weiteren thermoplastischen Material, ein Verfahren zu dessen Herstellung sowie dessen Verwendung in Kraftfahrzeugen
AU5325000A (en) * 1999-06-05 2000-12-28 David Houze Solubility enhancement of drugs in transdermal drug delivery systems and methodsof use
CN1146613C (zh) * 1999-09-10 2004-04-21 三井化学株式会社 可降解的聚氨酯树脂
US6565969B1 (en) * 1999-10-21 2003-05-20 3M Innovative Properties Company Adhesive article
US20030035786A1 (en) * 1999-11-04 2003-02-20 Medtronic, Inc. Biological tissue adhesives, articles, and methods
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6395112B1 (en) * 2000-02-04 2002-05-28 The United States Of America As Represented By The Secretary Of The Navy Hydrolyzable polymers for explosive and propellant binders
JP2003530156A (ja) * 2000-04-06 2003-10-14 ユニバーシティ ライセンス ホールディングス インコーポレイテッド 創傷治癒を促進するための組成物および方法
US6576702B2 (en) * 2000-07-20 2003-06-10 Noveon Ip Holdings Corp. Plasticized waterborne polyurethane dispersions and manufacturing process
US6605666B1 (en) * 2000-07-27 2003-08-12 3M Innovative Properties Company Polyurethane film-forming dispersions in alcohol-water system
GB0100760D0 (en) * 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US20030044380A1 (en) * 2001-07-19 2003-03-06 Zhu Yong Hua Adhesive including medicament
EP2462939A3 (en) * 2001-07-31 2012-08-15 Tyco Healthcare Group LP Bioabsorbable adhesive compounds and compositions
US20040068078A1 (en) * 2001-12-12 2004-04-08 Milbocker Michael T. In situ polymerizing medical compositions
US8501165B2 (en) * 2001-12-12 2013-08-06 Promethean Surgical Devices Llc In situ bonds
US20050131192A1 (en) * 2001-12-18 2005-06-16 Takehisa Matsuda Polymer and process for producing polymer
US6824703B2 (en) * 2002-03-08 2004-11-30 Bayer Materialscience Llc Polyurethane elastomers having improved physical properties and a process for the production thereof
US6897281B2 (en) * 2002-04-05 2005-05-24 Noveon Ip Holdings Corp. Breathable polyurethanes, blends, and articles
US20030089733A1 (en) * 2002-07-09 2003-05-15 Cain Russell P Medication monitoring device
US6972315B2 (en) * 2002-07-19 2005-12-06 Gross Richard A Enzyme-catalyzed polycondensations
CN1166715C (zh) * 2002-08-23 2004-09-15 清华大学 一种可生物降解聚氨酯弹性体的合成
AU2003287204B2 (en) * 2002-10-28 2008-12-11 Covidien Lp Fast curing compositions
US20040198944A1 (en) * 2003-03-04 2004-10-07 Meltzer Donald A. Thermoplastic polyurethanes
IL155866A0 (en) * 2003-05-12 2003-12-23 Yissum Res Dev Co Responsive polymeric system
WO2005034781A1 (en) * 2003-09-29 2005-04-21 Promethean Surgical Devices Llc Devices and methods for spine repair
US7514503B2 (en) * 2003-10-08 2009-04-07 Asahi Kasei Chemicals Corporation Molded article produced from aliphatic polyester resin composition
US20050129733A1 (en) * 2003-12-09 2005-06-16 Milbocker Michael T. Surgical adhesive and uses therefore
US8309112B2 (en) * 2003-12-24 2012-11-13 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
WO2005094724A1 (en) * 2004-03-29 2005-10-13 Promethean Surgical Devices Llc Surgical adhesive formulations and methods of preparation
EP1962867B1 (en) * 2005-12-06 2013-06-19 Covidien LP Biocompatible surgical compositions

Also Published As

Publication number Publication date
EP1960446A4 (en) 2010-11-24
WO2007067764A2 (en) 2007-06-14
EP1960446A2 (en) 2008-08-27
WO2007067764A3 (en) 2008-01-24
AU2006321856A1 (en) 2007-06-14
JP2009518138A (ja) 2009-05-07
AU2006321856B2 (en) 2013-01-31
US20070135606A1 (en) 2007-06-14

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Effective date: 20141209