CA2628920C - Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors - Google Patents

Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors Download PDF

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Publication number
CA2628920C
CA2628920C CA2628920A CA2628920A CA2628920C CA 2628920 C CA2628920 C CA 2628920C CA 2628920 A CA2628920 A CA 2628920A CA 2628920 A CA2628920 A CA 2628920A CA 2628920 C CA2628920 C CA 2628920C
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optionally substituted
group
nitrogen
compound
aryl group
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CA2628920A
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English (en)
French (fr)
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CA2628920A1 (en
Inventor
Marc Geoffrey Hummersone
Sylvie Gomez
Keith Allan Menear
Graeme Cameron Murray Smith
Karine Malagu
Heather Mary Ellen Duggan
Xiao-Ling Fan Cockcroft
Gesine Johanna Hermann
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Kudos Pharmaceuticals Ltd
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Kudos Pharmaceuticals Ltd
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Priority claimed from GB0524047A external-priority patent/GB0524047D0/en
Application filed by Kudos Pharmaceuticals Ltd filed Critical Kudos Pharmaceuticals Ltd
Publication of CA2628920A1 publication Critical patent/CA2628920A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA2628920A 2005-11-22 2006-11-20 Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors Active CA2628920C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US73890205P 2005-11-22 2005-11-22
US60/738,902 2005-11-22
GB0524047A GB0524047D0 (en) 2005-11-25 2005-11-25 Compounds
GB0524047.8 2005-11-25
US82330806P 2006-08-23 2006-08-23
US82330906P 2006-08-23 2006-08-23
US60/823,308 2006-08-23
US60/823,309 2006-08-23
PCT/GB2006/004327 WO2007060404A1 (en) 2005-11-22 2006-11-20 PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS

Publications (2)

Publication Number Publication Date
CA2628920A1 CA2628920A1 (en) 2007-05-31
CA2628920C true CA2628920C (en) 2015-12-29

Family

ID=37533284

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2628920A Active CA2628920C (en) 2005-11-22 2006-11-20 Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors

Country Status (15)

Country Link
US (1) US20080194546A1 (https=)
EP (1) EP1954699B1 (https=)
JP (1) JP5161102B2 (https=)
KR (1) KR101464384B1 (https=)
AR (1) AR057626A1 (https=)
AU (1) AU2006318948B2 (https=)
CA (1) CA2628920C (https=)
EC (1) ECSP088536A (https=)
HR (1) HRP20120963T1 (https=)
IL (1) IL191196A (https=)
NO (1) NO341055B1 (https=)
PL (1) PL1954699T3 (https=)
TW (1) TWI452047B (https=)
UY (1) UY29938A1 (https=)
WO (1) WO2007060404A1 (https=)

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Also Published As

Publication number Publication date
HK1124039A1 (en) 2009-07-03
AU2006318948A1 (en) 2007-05-31
NO341055B1 (no) 2017-08-14
AU2006318948B2 (en) 2011-02-24
IL191196A (en) 2016-02-29
KR101464384B1 (ko) 2014-11-21
WO2007060404A1 (en) 2007-05-31
US20080194546A1 (en) 2008-08-14
KR20080070079A (ko) 2008-07-29
PL1954699T3 (pl) 2013-01-31
JP2009516727A (ja) 2009-04-23
NO20082101L (no) 2008-08-15
EP1954699A1 (en) 2008-08-13
JP5161102B2 (ja) 2013-03-13
AR057626A1 (es) 2007-12-05
EP1954699B1 (en) 2012-09-19
CA2628920A1 (en) 2007-05-31
TW200738706A (en) 2007-10-16
HRP20120963T1 (hr) 2012-12-31
ECSP088536A (es) 2008-07-30
UY29938A1 (es) 2007-06-29
TWI452047B (zh) 2014-09-11

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