CA2628179A1 - Azaindazoles useful as inhibitors of kinases - Google Patents
Azaindazoles useful as inhibitors of kinases Download PDFInfo
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- CA2628179A1 CA2628179A1 CA002628179A CA2628179A CA2628179A1 CA 2628179 A1 CA2628179 A1 CA 2628179A1 CA 002628179 A CA002628179 A CA 002628179A CA 2628179 A CA2628179 A CA 2628179A CA 2628179 A1 CA2628179 A1 CA 2628179A1
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US73710505P | 2005-11-15 | 2005-11-15 | |
| US60/737,105 | 2005-11-15 | ||
| PCT/US2006/044361 WO2007059219A1 (en) | 2005-11-15 | 2006-11-15 | Azaindazoles useful as inhibitors of kinases |
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| WO2007089862A2 (en) * | 2006-01-31 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
| CN101790532B (zh) * | 2007-07-31 | 2013-11-20 | 沃泰克斯药物股份有限公司 | 5-氟-1H-吡唑并[3，4-b]吡啶-3-胺及其衍生物的制备方法 |
| US8466149B2 (en) | 2007-08-15 | 2013-06-18 | Merck Sharp & Dohme Corp. | 6-substituted sulfonyl azabicyclo[3.2.1]octanes useful to inhibit 11β-hydroxysteroid dehydrogenase type-I |
| JP5608097B2 (ja) | 2008-01-08 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピロロピリジン |
| US8372842B2 (en) | 2008-01-09 | 2013-02-12 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
| WO2009103010A2 (en) * | 2008-02-13 | 2009-08-20 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP3068782B1 (en) | 2013-11-13 | 2018-05-23 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| ES2741444T3 (es) | 2013-11-13 | 2020-02-11 | Vertex Pharma | Inhibidores de la replicación de virus de la gripe |
| WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| US10590077B2 (en) * | 2016-09-20 | 2020-03-17 | Glaxosmithkline Intellectual Property Development Limited | TRPV4 antagonists |
| CN116687951A (zh) * | 2023-06-06 | 2023-09-05 | 河北渤腾医药技术有限公司 | 一种plk1的干扰rna及其应用 |
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| US5654400A (en) | 1991-10-04 | 1997-08-05 | Fujisawa Pharmaceutical Co., Ltd. | Process for making peptide compounds having tachykinin antagonistic activity |
| JP3485198B2 (ja) | 1993-11-10 | 2004-01-13 | 富士写真フイルム株式会社 | ヒドラジン化合物及び該化合物を含むハロゲン化銀写真感光材料 |
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| US6537999B2 (en) | 1996-06-06 | 2003-03-25 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
| JP4028607B2 (ja) | 1996-07-24 | 2007-12-26 | 富山化学工業株式会社 | 新規なセファロスポリン誘導体またはその塩 |
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| CA2325995A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
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| US6025366A (en) | 1998-04-02 | 2000-02-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6110931A (en) | 1998-04-02 | 2000-08-29 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| BR9913654A (pt) * | 1998-08-28 | 2001-11-27 | Scios Inc | Inibidores de p-38alfa quinase |
| US6319660B1 (en) | 1998-12-28 | 2001-11-20 | Eastman Kodak Company | Color photographic element containing speed improving compound |
| CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| CO5170498A1 (es) * | 1999-05-28 | 2002-06-27 | Abbott Lab | Biaril sulfonamidas son utiles como inhibidores de proliferacion celular |
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| HUP0204560A3 (en) | 2000-02-04 | 2005-03-29 | Pfizer Prod Inc | Heterocyclic amide derivatives and pharmaceutical compositions containing them and their use |
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| GB0106661D0 (en) | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| WO2003000690A1 (en) | 2001-06-25 | 2003-01-03 | Aventis Pharmaceuticals Inc. | Synthesis of heterocyclic compounds employing microwave technology |
| GB0128287D0 (en) * | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
| TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| CA2493625A1 (en) | 2002-07-25 | 2004-02-19 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| GB0218800D0 (en) | 2002-08-13 | 2002-09-18 | Celltech R&D Ltd | Chemical compounds |
| GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
| BRPI0407811A (pt) | 2003-02-27 | 2006-02-14 | Uriach Y Compania S A J | composto derivados de pirazolopiridina, processo para a preparação dos mesmos, composição farmacêutica e respectivos uso |
| RU2357957C2 (ru) | 2003-03-03 | 2009-06-10 | Эррэй Биофарма, Инк. | Ингибиторы р38 и способы их применения |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN1809559B (zh) | 2003-04-18 | 2010-06-02 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的吡唑衍生物 |
| US7638530B2 (en) | 2003-04-24 | 2009-12-29 | Merck & Co., Inc. | Inhibitors of Akt activity |
| US7872014B2 (en) | 2003-07-23 | 2011-01-18 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| US7132435B2 (en) | 2003-07-25 | 2006-11-07 | Pfizer Inc. | Compounds |
| GB0317471D0 (en) | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Novel compounds |
| GB0317482D0 (en) | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| CA2572750A1 (en) | 2003-09-10 | 2005-03-17 | Anil Koul | Heterobicyclic compounds as pharmaceutically active agents |
| EP1678171B1 (en) | 2003-10-21 | 2016-09-14 | Cyclacel Limited | 2-amino-4-thiazolone-pyrimidine derivatives as protein kinase inhibitors |
| JP2007523938A (ja) * | 2004-02-27 | 2007-08-23 | エフ．ホフマン−ラ ロシュ アーゲー | ピラゾールの縮合誘導体 |
| EP1778687A2 (en) * | 2004-07-27 | 2007-05-02 | SGX Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
-
2006
- 2006-11-15 US US11/600,311 patent/US8017781B2/en not_active Expired - Fee Related
- 2006-11-15 WO PCT/US2006/044361 patent/WO2007059219A1/en not_active Ceased
- 2006-11-15 EP EP11191099A patent/EP2514751A1/en not_active Withdrawn
- 2006-11-15 JP JP2008541312A patent/JP2009515984A/ja active Pending
- 2006-11-15 CN CNA2006800507344A patent/CN101365700A/zh active Pending
- 2006-11-15 AU AU2006315436A patent/AU2006315436A1/en not_active Abandoned
- 2006-11-15 CA CA002628179A patent/CA2628179A1/en not_active Abandoned
- 2006-11-15 EP EP06837683A patent/EP1948657A1/en not_active Withdrawn
-
2011
- 2011-07-29 US US13/193,739 patent/US8445681B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2514751A1 (en) | 2012-10-24 |
| US8445681B2 (en) | 2013-05-21 |
| US20070179177A1 (en) | 2007-08-02 |
| CN101365700A (zh) | 2009-02-11 |
| JP2009515984A (ja) | 2009-04-16 |
| AU2006315436A1 (en) | 2007-05-24 |
| US20120165367A1 (en) | 2012-06-28 |
| US8017781B2 (en) | 2011-09-13 |
| WO2007059219A1 (en) | 2007-05-24 |
| EP1948657A1 (en) | 2008-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20131115 |