CA2627628A1 - Novel fluorescent dyes and uses thereof - Google Patents

Novel fluorescent dyes and uses thereof Download PDF

Info

Publication number
CA2627628A1
CA2627628A1 CA 2627628 CA2627628A CA2627628A1 CA 2627628 A1 CA2627628 A1 CA 2627628A1 CA 2627628 CA2627628 CA 2627628 CA 2627628 A CA2627628 A CA 2627628A CA 2627628 A1 CA2627628 A1 CA 2627628A1
Authority
CA
Canada
Prior art keywords
dye
substituted
ring
group
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2627628
Other languages
English (en)
French (fr)
Inventor
Robert Ramage
Beatrice Maltman
Graham Cotton
Sarah Claire Monique Couturier
Robert Austin Simms Mcmordie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almac Sciences Scotland Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0522029A external-priority patent/GB0522029D0/en
Priority claimed from GB0613334A external-priority patent/GB0613334D0/en
Application filed by Individual filed Critical Individual
Publication of CA2627628A1 publication Critical patent/CA2627628A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA 2627628 2005-10-28 2006-10-27 Novel fluorescent dyes and uses thereof Abandoned CA2627628A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0522029.8 2005-10-28
GB0522029A GB0522029D0 (en) 2005-10-28 2005-10-28 Novel fluorescent dyes and uses
GB0613334A GB0613334D0 (en) 2006-07-05 2006-07-05 Novel fluorescent dyes and uses thereof (II)
GB0613334.2 2006-07-05
PCT/GB2006/004015 WO2007049057A2 (en) 2005-10-28 2006-10-27 Novel fluorescent dyes and uses thereof

Publications (1)

Publication Number Publication Date
CA2627628A1 true CA2627628A1 (en) 2007-05-03

Family

ID=37968186

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2627628 Abandoned CA2627628A1 (en) 2005-10-28 2006-10-27 Novel fluorescent dyes and uses thereof

Country Status (5)

Country Link
US (1) US9127164B2 (enExample)
EP (1) EP1940965B1 (enExample)
JP (1) JP5548363B2 (enExample)
CA (1) CA2627628A1 (enExample)
WO (1) WO2007049057A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0712109D0 (en) * 2007-06-22 2007-08-01 Edinburgh Instr Fluorescence lifetime and fluorescence assays
US20110236983A1 (en) * 2009-12-29 2011-09-29 Joseph Beechem Single molecule detection and sequencing using fluorescence lifetime imaging
WO2012110833A2 (en) 2011-02-18 2012-08-23 Almac Sciences (Scotland) Limited Fluorescence modulators
US20140080162A1 (en) 2011-03-25 2014-03-20 Almac Sciences (Scotland) Limited Fluorescence lifetime epigenetics assays
GB201122099D0 (en) 2011-12-22 2012-02-01 Almac Sciences Scotland Ltd Dyes
CN103373967A (zh) * 2013-07-08 2013-10-30 大连九信生物化工科技有限公司 一种申嗪霉素的合成方法
WO2016116111A1 (en) * 2015-01-21 2016-07-28 Københavns Universitet Substituted acridine-like and xanthenium-like fluorescent dyes
RU2622753C1 (ru) * 2016-11-17 2017-06-19 Федеральное государственное бюджетное учреждение "Национальный научно-практический центр сердечно-сосудистой хирургии имени А.Н. Бакулева" Министерства здравоохранения Российской Федерации (ФГБУ "ННПЦССХ им. А.Н. Бакулева" Минздрава России) Способ определения активности ангиотензин-превращающего фермента в тканях сердца
CN108640873A (zh) * 2018-06-25 2018-10-12 福建医科大学 一种亚胺类吖啶衍生物荧光探针及其制备方法和检测MORAb-3-1抗体应用
CN108947901A (zh) * 2018-06-25 2018-12-07 福建医科大学 一种亚胺类吖啶衍生物荧光探针制备及检测甲状腺球蛋白抗体的方法
CN109354586A (zh) * 2018-09-29 2019-02-19 福建医科大学 一种亚胺类吖啶荧光探针制备及标记口腔鳞癌细胞中bcl-2蛋白方法
CA3127235A1 (en) 2019-01-21 2020-07-30 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. Sulfonated 2(7)-aminoacridone and 1-aminopyrene dyes and their use as fluorescent tags, in particular for carbohydrate analysis
EP4069784A1 (en) 2019-12-06 2022-10-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Aminoacridine and aminopyrene dyes and their use as fluorescent tags, in particular for carbohydrate analysis
CN115109066B (zh) * 2022-06-30 2023-04-07 武汉工程大学 一种大斯托克斯位移检测弹性蛋白酶的荧光探针及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE393411C (de) * 1921-10-11 1924-04-04 Hoechst Ag Verfahren zur Darstellung von Akridinderivaten
US5296599A (en) 1991-09-19 1994-03-22 Millipore Corporation Activated carbamates compounds
IL149402A0 (en) 1999-11-29 2002-11-10 Aventis Pharma Sa Arylamine derivatives and their use as anti-telomerase agent
DE10117430A1 (de) 2001-04-06 2002-10-10 Nicole Marme Hochempfindlicher und hochspezifischer Enzymnachweis mit einer Nachweisgrenze bis in den femtomolaren Bereich
GB0113435D0 (en) 2001-06-04 2001-07-25 Amersham Pharm Biotech Uk Ltd Acridone derivatives as labels for fluorescence detection of target materials
GB0208987D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring protein kinase and phosphatase activity
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity

Also Published As

Publication number Publication date
EP1940965B1 (en) 2014-03-26
EP1940965A2 (en) 2008-07-09
US9127164B2 (en) 2015-09-08
JP5548363B2 (ja) 2014-07-16
US20090226940A1 (en) 2009-09-10
WO2007049057A2 (en) 2007-05-03
WO2007049057A3 (en) 2007-10-04
JP2009513766A (ja) 2009-04-02

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20121029