CA2626383C - Spectrometrie de masse avec guides d'ions multipolaires - Google Patents
Spectrometrie de masse avec guides d'ions multipolaires Download PDFInfo
- Publication number
- CA2626383C CA2626383C CA2626383A CA2626383A CA2626383C CA 2626383 C CA2626383 C CA 2626383C CA 2626383 A CA2626383 A CA 2626383A CA 2626383 A CA2626383 A CA 2626383A CA 2626383 C CA2626383 C CA 2626383C
- Authority
- CA
- Canada
- Prior art keywords
- quadrupole
- ion
- ions
- mass
- ion guide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005405 multipole Effects 0.000 title claims abstract description 260
- 238000004949 mass spectrometry Methods 0.000 title description 5
- 150000002500 ions Chemical class 0.000 claims abstract description 1759
- 238000013467 fragmentation Methods 0.000 claims abstract description 243
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 243
- 230000007935 neutral effect Effects 0.000 claims abstract description 67
- 238000004885 tandem mass spectrometry Methods 0.000 claims description 131
- 238000004458 analytical method Methods 0.000 claims description 128
- 238000005086 pumping Methods 0.000 claims description 109
- 230000005284 excitation Effects 0.000 claims description 77
- 238000000034 method Methods 0.000 claims description 75
- 230000002829 reductive effect Effects 0.000 claims description 24
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- 230000001133 acceleration Effects 0.000 description 87
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- 238000005040 ion trap Methods 0.000 description 53
- 238000010884 ion-beam technique Methods 0.000 description 42
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- 230000001965 increasing effect Effects 0.000 description 35
- 239000012071 phase Substances 0.000 description 34
- 230000002441 reversible effect Effects 0.000 description 28
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 25
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 238000005457 optimization Methods 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000002366 time-of-flight method Methods 0.000 description 6
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 5
- 230000032258 transport Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000005251 capillar electrophoresis Methods 0.000 description 4
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- 229910052786 argon Inorganic materials 0.000 description 3
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- 238000000132 electrospray ionisation Methods 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 238000009616 inductively coupled plasma Methods 0.000 description 3
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- 230000000979 retarding effect Effects 0.000 description 3
- 238000002098 selective ion monitoring Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 238000000451 chemical ionisation Methods 0.000 description 2
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- 230000000977 initiatory effect Effects 0.000 description 2
- 230000037427 ion transport Effects 0.000 description 2
- 238000000534 ion trap mass spectrometry Methods 0.000 description 2
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- 238000002663 nebulization Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
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- 239000012488 sample solution Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 230000000153 supplemental effect Effects 0.000 description 2
- 238000001196 time-of-flight mass spectrum Methods 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 102100022432 Sclerostin domain-containing protein 1 Human genes 0.000 description 1
- 238000012442 analytical experiment Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 230000035559 beat frequency Effects 0.000 description 1
- 238000005513 bias potential Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
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- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000755 effect on ion Effects 0.000 description 1
- 238000010292 electrical insulation Methods 0.000 description 1
- 238000001803 electron scattering Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
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- 230000001939 inductive effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004969 ion scattering spectroscopy Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- -1 mariner ions Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000005173 quadrupole mass spectroscopy Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
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- 230000003595 spectral effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8724698P | 1998-05-29 | 1998-05-29 | |
| US60/087,246 | 1998-05-29 | ||
| US23594699A | 1999-01-22 | 1999-01-22 | |
| US09/235,946 | 1999-01-22 | ||
| CA002332534A CA2332534C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Division CA2332534C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2626383A1 CA2626383A1 (fr) | 1999-12-02 |
| CA2626383C true CA2626383C (fr) | 2011-07-19 |
Family
ID=26776766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Expired - Lifetime CA2332534C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
| CA2626383A Expired - Lifetime CA2626383C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Expired - Lifetime CA2332534C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1090412B1 (fr) |
| JP (1) | JP2002517070A (fr) |
| AU (1) | AU4326599A (fr) |
| CA (2) | CA2332534C (fr) |
| WO (1) | WO1999062101A1 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9820210D0 (en) | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
| CA2326514A1 (fr) * | 2000-01-10 | 2001-07-10 | Mds Inc. | Appareil et methode permettant la distinction des especes ionisees non desirees, en spectrometrie de masse, au moyen de dispositifs de reaction et d'impact |
| US6720554B2 (en) * | 2000-07-21 | 2004-04-13 | Mds Inc. | Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps |
| GB2370685B (en) | 2000-11-29 | 2003-01-22 | Micromass Ltd | Mass spectrometers and methods of mass spectrometry |
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
| JP3620479B2 (ja) * | 2001-07-31 | 2005-02-16 | 株式会社島津製作所 | イオン蓄積装置におけるイオン選別の方法 |
| AU2002350343A1 (en) * | 2001-12-21 | 2003-07-15 | Mds Inc., Doing Business As Mds Sciex | Use of notched broadband waveforms in a linear ion trap |
| GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
| US7095013B2 (en) | 2002-05-30 | 2006-08-22 | Micromass Uk Limited | Mass spectrometer |
| DE60308096T2 (de) * | 2002-05-30 | 2007-03-01 | Micromass UK Ltd., Simonsway | Massenspektrometer |
| US7034292B1 (en) | 2002-05-31 | 2006-04-25 | Analytica Of Branford, Inc. | Mass spectrometry with segmented RF multiple ion guides in various pressure regions |
| CA2641940C (fr) * | 2002-05-31 | 2011-11-15 | Analytica Of Branford, Inc. | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| WO2004068523A2 (fr) * | 2003-01-24 | 2004-08-12 | Thermo Finnigan Llc | Regulation de populations d'ions dans un analyseur de masse |
| DE10326156B4 (de) * | 2003-06-10 | 2011-12-01 | Micromass Uk Ltd. | Massenspektrometer mit Gaskollisionszelle und Wechselspannungs- oder HF-Ionenführung mit differentiellen Druckbereichen sowie zugehörige Verfahren zur Massenspektrometrie |
| US6977371B2 (en) | 2003-06-10 | 2005-12-20 | Micromass Uk Limited | Mass spectrometer |
| DE102004014582B4 (de) * | 2004-03-25 | 2009-08-20 | Bruker Daltonik Gmbh | Ionenoptische Phasenvolumenkomprimierung |
| JP2005276787A (ja) * | 2004-03-26 | 2005-10-06 | Tsutomu Masujima | 質量分析装置 |
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| GB0416288D0 (en) * | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| JP4848657B2 (ja) * | 2005-03-28 | 2011-12-28 | 株式会社島津製作所 | Ｍｓ／ｍｓ型質量分析装置 |
| GB0506288D0 (en) * | 2005-03-29 | 2005-05-04 | Thermo Finnigan Llc | Improvements relating to mass spectrometry |
| GB2427067B (en) * | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
| WO2007076606A1 (fr) * | 2006-01-05 | 2007-07-12 | Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division | Acquisition dépendante de l'information déclenchée par défaut de masse |
| US7378653B2 (en) * | 2006-01-10 | 2008-05-27 | Varian, Inc. | Increasing ion kinetic energy along axis of linear ion processing devices |
| GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| US8507850B2 (en) * | 2007-05-31 | 2013-08-13 | Perkinelmer Health Sciences, Inc. | Multipole ion guide interface for reduced background noise in mass spectrometry |
| JP2008108739A (ja) * | 2007-11-26 | 2008-05-08 | Hitachi High-Technologies Corp | 質量分析装置およびこれを用いる計測システム |
| CA2713832C (fr) * | 2008-01-30 | 2016-04-12 | Dh Technologies Development Pte. Ltd. | Fragmentation d'ions en spectrometrie de masse |
| GB2484136B (en) * | 2010-10-01 | 2015-09-16 | Thermo Fisher Scient Bremen | Method and apparatus for improving the throughput of a charged particle analysis system |
| US9202679B2 (en) | 2010-11-26 | 2015-12-01 | Analytik Jena Ag | Electrically connected sample interface for mass spectrometer |
| JP2011119279A (ja) * | 2011-03-11 | 2011-06-16 | Hitachi High-Technologies Corp | 質量分析装置およびこれを用いる計測システム |
| CN104160474A (zh) * | 2012-02-01 | 2014-11-19 | Dh科技发展私人贸易有限公司 | 用于提高质谱仪中的灵敏度的方法及设备 |
| WO2014197348A2 (fr) * | 2013-06-03 | 2014-12-11 | Perkinelmer Health Sciences, Inc. | Guide d'ions ou filtres présentant une conductance de gaz sélectionnée |
| GB201715777D0 (en) * | 2017-09-29 | 2017-11-15 | Shimadzu Corp | ION Trap |
| KR102305532B1 (ko) * | 2020-03-04 | 2021-09-27 | 한국원자력안전기술원 | 불활성 기체 정성 및 정량 분석 장치 및 방법 |
| CN111640646A (zh) * | 2020-06-15 | 2020-09-08 | 成都艾立本科技有限公司 | 一种高灵敏度质子转移飞行时间质谱仪及使用该质谱仪进行离子飞行时间测量的方法 |
| CN111613514B (zh) * | 2020-06-24 | 2023-11-03 | 成都艾立本科技有限公司 | 一种高灵敏度紫外光电离飞行时间质谱仪及离子飞行时间测量方法 |
| JP7509317B2 (ja) | 2021-05-11 | 2024-07-02 | 株式会社島津製作所 | 直交加速飛行時間型質量分析装置 |
| US11501962B1 (en) * | 2021-06-17 | 2022-11-15 | Thermo Finnigan Llc | Device geometries for controlling mass spectrometer pressures |
| GB202114780D0 (en) * | 2021-10-15 | 2021-12-01 | Thermo Fisher Scient Bremen Gmbh | Ion transport between ion optical devices at different gas pressures |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4328420A (en) | 1980-07-28 | 1982-05-04 | French John B | Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system |
| EP0237259A3 (fr) * | 1986-03-07 | 1989-04-05 | Finnigan Corporation | Spectromètre de masse |
| US5179278A (en) * | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| WO1995023018A1 (fr) | 1994-02-28 | 1995-08-31 | Analytica Of Branford, Inc. | Guide d'ions multipolaire pour spectrometrie de masse |
| DE19511333C1 (de) * | 1995-03-28 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer |
| US6075244A (en) * | 1995-07-03 | 2000-06-13 | Hitachi, Ltd. | Mass spectrometer |
| AU6653296A (en) * | 1995-08-11 | 1997-03-12 | Mds Health Group Limited | Spectrometer with axial field |
| JP3818671B2 (ja) * | 1996-06-06 | 2006-09-06 | エムディーエス インコーポレーテッド | 多重極子質量分光計の軸方向射出方法 |
| DE69806415T2 (de) * | 1997-12-05 | 2003-02-20 | The University Of British Columbia, Vancouver | Verfahren zur untersuchung von ionen in einem apparat mit einem flugzeit-spektrometer und einer linearen quadrupol-ionenfalle |
| AU2334199A (en) * | 1998-01-23 | 1999-08-09 | Analytica Of Branford, Inc. | Mass spectrometry with multipole ion guide |
-
1999
- 1999-05-29 AU AU43265/99A patent/AU4326599A/en not_active Abandoned
- 1999-05-29 CA CA002332534A patent/CA2332534C/fr not_active Expired - Lifetime
- 1999-05-29 JP JP2000551420A patent/JP2002517070A/ja active Pending
- 1999-05-29 CA CA2626383A patent/CA2626383C/fr not_active Expired - Lifetime
- 1999-05-29 EP EP99953401.9A patent/EP1090412B1/fr not_active Expired - Lifetime
- 1999-05-29 WO PCT/US1999/012169 patent/WO1999062101A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP1090412A1 (fr) | 2001-04-11 |
| EP1090412B1 (fr) | 2014-03-05 |
| CA2626383A1 (fr) | 1999-12-02 |
| CA2332534C (fr) | 2008-07-22 |
| WO1999062101A9 (fr) | 2000-03-02 |
| JP2002517070A (ja) | 2002-06-11 |
| CA2332534A1 (fr) | 1999-12-02 |
| AU4326599A (en) | 1999-12-13 |
| WO1999062101A1 (fr) | 1999-12-02 |
| EP1090412A4 (fr) | 2006-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190529 |