CA2332534C - Spectrometrie de masse avec guides d'ions multipolaires - Google Patents
Spectrometrie de masse avec guides d'ions multipolaires Download PDFInfo
- Publication number
- CA2332534C CA2332534C CA002332534A CA2332534A CA2332534C CA 2332534 C CA2332534 C CA 2332534C CA 002332534 A CA002332534 A CA 002332534A CA 2332534 A CA2332534 A CA 2332534A CA 2332534 C CA2332534 C CA 2332534C
- Authority
- CA
- Canada
- Prior art keywords
- ion
- quadrupole
- ions
- ion guide
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005405 multipole Effects 0.000 title claims abstract description 280
- 238000004949 mass spectrometry Methods 0.000 title description 5
- 150000002500 ions Chemical class 0.000 claims abstract description 1756
- 238000013467 fragmentation Methods 0.000 claims abstract description 232
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 232
- 230000007935 neutral effect Effects 0.000 claims abstract description 50
- 238000010494 dissociation reaction Methods 0.000 claims abstract description 9
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- 238000005086 pumping Methods 0.000 claims description 127
- 238000004458 analytical method Methods 0.000 claims description 120
- 238000000034 method Methods 0.000 claims description 75
- 238000005040 ion trap Methods 0.000 claims description 55
- 238000012546 transfer Methods 0.000 claims description 21
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- BTFMCMVEUCGQDX-UHFFFAOYSA-N 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone Chemical compound C12=CC(C(=O)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCC(CCO)CC1 BTFMCMVEUCGQDX-UHFFFAOYSA-N 0.000 description 1
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- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
Abstract
L'invention concerne un spectromètre de masse (40) comprenant plusieurs guides d'ions multipolaires (60, 62) qui se présentent sous la forme d'un ensemble aligné le long d'une même ligne centrale (5), au moins une partie de chaque guide d'ions multipolaire (60, 62) de cet ensemble étant placée dans une zone de vide (72, 73) avec une pression de fond élevée. Ces guides d'ions mutipolaires (60, 62), qui sont placés dans une zone de vide (72, 73) d'une pression de fond élevée, fonctionnent en modes de sélection masse/charge et de fragmentation d'ions. Des ensembles distincts de sources de tension radiofréquence, à courant continu +/-, et à fréquence de résonance en forme d'onde fournissent des potentiels aux tiges de chaque guide d'ions multipolaire, ce qui confère donc des fonctions d'émission d'ions, de piégeage d'ions, de sélection masse-charge, et de fragmentation d'ions, à chaque guide d'ions (60, 62). La présence d'une pression de fond suffisamment élevée pour provoquer des collisions entre les ions et le gaz neutre, le long d'une partie de chaque ensemble linéaire de guides d'ions mutipolaires, permet par ailleurs d'obtenir une fragmentation des ions par dissociation induite par collisions (CID), grâce à l'accélération axiale de ces ions depuis l'un des guides d'ions mutipolaires jusqu'à un guide d'ions adjacent, ce qui est analogue à une triple fonction quadripolaire.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2626383A CA2626383C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8724698P | 1998-05-29 | 1998-05-29 | |
| US60/087,246 | 1998-05-29 | ||
| US23594699A | 1999-01-22 | 1999-01-22 | |
| US09/235,946 | 1999-01-22 | ||
| PCT/US1999/012169 WO1999062101A1 (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2626383A Division CA2626383C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2332534A1 CA2332534A1 (fr) | 1999-12-02 |
| CA2332534C true CA2332534C (fr) | 2008-07-22 |
Family
ID=26776766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332534A Expired - Lifetime CA2332534C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
| CA2626383A Expired - Lifetime CA2626383C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2626383A Expired - Lifetime CA2626383C (fr) | 1998-05-29 | 1999-05-29 | Spectrometrie de masse avec guides d'ions multipolaires |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1090412B1 (fr) |
| JP (1) | JP2002517070A (fr) |
| AU (1) | AU4326599A (fr) |
| CA (2) | CA2332534C (fr) |
| WO (1) | WO1999062101A1 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9820210D0 (en) * | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
| CA2326514A1 (fr) * | 2000-01-10 | 2001-07-10 | Mds Inc. | Appareil et methode permettant la distinction des especes ionisees non desirees, en spectrometrie de masse, au moyen de dispositifs de reaction et d'impact |
| US6720554B2 (en) * | 2000-07-21 | 2004-04-13 | Mds Inc. | Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps |
| US6642514B2 (en) | 2000-11-29 | 2003-11-04 | Micromass Limited | Mass spectrometers and methods of mass spectrometry |
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
| JP3620479B2 (ja) * | 2001-07-31 | 2005-02-16 | 株式会社島津製作所 | イオン蓄積装置におけるイオン選別の方法 |
| WO2003056604A1 (fr) * | 2001-12-21 | 2003-07-10 | Mds Inc., Doing Business As Mds Sciex | Utilisation de formes d'ondes large bande a encoche dans un piege a ions lineaire |
| GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
| ATE339011T1 (de) * | 2002-05-30 | 2006-09-15 | Micromass Ltd | Massenspektrometer |
| US7095013B2 (en) | 2002-05-30 | 2006-08-22 | Micromass Uk Limited | Mass spectrometer |
| CA2641940C (fr) | 2002-05-31 | 2011-11-15 | Analytica Of Branford, Inc. | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
| US7034292B1 (en) | 2002-05-31 | 2006-04-25 | Analytica Of Branford, Inc. | Mass spectrometry with segmented RF multiple ion guides in various pressure regions |
| GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| JP5322385B2 (ja) * | 2003-01-24 | 2013-10-23 | サーモ フィニガン リミテッド ライアビリティ カンパニー | 質量分析器におけるイオン集団の制御 |
| CA2431603C (fr) | 2003-06-10 | 2012-03-27 | Micromass Uk Limited | Spectrometre de masse |
| DE10326156B4 (de) * | 2003-06-10 | 2011-12-01 | Micromass Uk Ltd. | Massenspektrometer mit Gaskollisionszelle und Wechselspannungs- oder HF-Ionenführung mit differentiellen Druckbereichen sowie zugehörige Verfahren zur Massenspektrometrie |
| DE102004014582B4 (de) * | 2004-03-25 | 2009-08-20 | Bruker Daltonik Gmbh | Ionenoptische Phasenvolumenkomprimierung |
| JP2005276787A (ja) * | 2004-03-26 | 2005-10-06 | Tsutomu Masujima | 質量分析装置 |
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| GB0416288D0 (en) | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| JP4848657B2 (ja) * | 2005-03-28 | 2011-12-28 | 株式会社島津製作所 | Ｍｓ／ｍｓ型質量分析装置 |
| GB2427067B (en) * | 2005-03-29 | 2010-02-24 | Thermo Finnigan Llc | Improvements relating to ion trapping |
| GB0506288D0 (en) * | 2005-03-29 | 2005-05-04 | Thermo Finnigan Llc | Improvements relating to mass spectrometry |
| WO2007076606A1 (fr) * | 2006-01-05 | 2007-07-12 | Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division | Acquisition dépendante de l'information déclenchée par défaut de masse |
| US7378653B2 (en) * | 2006-01-10 | 2008-05-27 | Varian, Inc. | Increasing ion kinetic energy along axis of linear ion processing devices |
| GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| US8507850B2 (en) | 2007-05-31 | 2013-08-13 | Perkinelmer Health Sciences, Inc. | Multipole ion guide interface for reduced background noise in mass spectrometry |
| JP2008108739A (ja) * | 2007-11-26 | 2008-05-08 | Hitachi High-Technologies Corp | 質量分析装置およびこれを用いる計測システム |
| EP2245650A4 (fr) * | 2008-01-30 | 2015-11-18 | Dh Technologies Dev Pte Ltd | Fragmentation d'ions en spectrométrie de masse |
| GB2484136B (en) * | 2010-10-01 | 2015-09-16 | Thermo Fisher Scient Bremen | Method and apparatus for improving the throughput of a charged particle analysis system |
| CA2818001A1 (fr) | 2010-11-26 | 2012-05-31 | Bruker Biosciences Pty Ltd | Ameliorations concernant ou liees a la spectrometrie de masse |
| JP2011119279A (ja) * | 2011-03-11 | 2011-06-16 | Hitachi High-Technologies Corp | 質量分析装置およびこれを用いる計測システム |
| EP2810297A4 (fr) * | 2012-02-01 | 2015-06-24 | Dh Technologies Dev Pte Ltd | Procédé et appareil pouvant améliorer la sensibilité d'un spectromètre de masse |
| WO2014197348A2 (fr) * | 2013-06-03 | 2014-12-11 | Perkinelmer Health Sciences, Inc. | Guide d'ions ou filtres présentant une conductance de gaz sélectionnée |
| GB201715777D0 (en) * | 2017-09-29 | 2017-11-15 | Shimadzu Corp | ION Trap |
| KR102305532B1 (ko) * | 2020-03-04 | 2021-09-27 | 한국원자력안전기술원 | 불활성 기체 정성 및 정량 분석 장치 및 방법 |
| CN111640646A (zh) * | 2020-06-15 | 2020-09-08 | 成都艾立本科技有限公司 | 一种高灵敏度质子转移飞行时间质谱仪及使用该质谱仪进行离子飞行时间测量的方法 |
| CN111613514B (zh) * | 2020-06-24 | 2023-11-03 | 成都艾立本科技有限公司 | 一种高灵敏度紫外光电离飞行时间质谱仪及离子飞行时间测量方法 |
| WO2022239104A1 (fr) * | 2021-05-11 | 2022-11-17 | 株式会社島津製作所 | Spectromètre de masse à temps de vol à accélération orthogonale |
| US11501962B1 (en) * | 2021-06-17 | 2022-11-15 | Thermo Finnigan Llc | Device geometries for controlling mass spectrometer pressures |
| GB202114780D0 (en) * | 2021-10-15 | 2021-12-01 | Thermo Fisher Scient Bremen Gmbh | Ion transport between ion optical devices at different gas pressures |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4328420A (en) | 1980-07-28 | 1982-05-04 | French John B | Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system |
| EP0237259A3 (fr) * | 1986-03-07 | 1989-04-05 | Finnigan Corporation | Spectromètre de masse |
| US5179278A (en) * | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| EP0748249B1 (fr) | 1994-02-28 | 2009-07-08 | Analytica Of Branford, Inc. | Guide d'ions multipolaire pour spectrometrie de masse |
| US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| DE19511333C1 (de) * | 1995-03-28 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer |
| EP0871201B1 (fr) * | 1995-07-03 | 2010-09-15 | Hitachi, Ltd. | Spectrometre de masse |
| EP0843887A1 (fr) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spectrometre a champ axial |
| CA2256028C (fr) * | 1996-06-06 | 2007-01-16 | Mds Inc. | Spectrometre de masse multipolaire a ejection axiale |
| CA2312806A1 (fr) * | 1997-12-05 | 1999-06-17 | University Of British Columbia | Procede d'analyse d'ions dans un appareil comprenant un spectrometre de masse a temps de vol et un piege a ions lineaire |
| WO1999038193A1 (fr) * | 1998-01-23 | 1999-07-29 | Analytica Of Branford, Inc. | Spectrometrie de masse a guide d'ions multipolaire |
-
1999
- 1999-05-29 WO PCT/US1999/012169 patent/WO1999062101A1/fr active Application Filing
- 1999-05-29 CA CA002332534A patent/CA2332534C/fr not_active Expired - Lifetime
- 1999-05-29 EP EP99953401.9A patent/EP1090412B1/fr not_active Expired - Lifetime
- 1999-05-29 JP JP2000551420A patent/JP2002517070A/ja active Pending
- 1999-05-29 CA CA2626383A patent/CA2626383C/fr not_active Expired - Lifetime
- 1999-05-29 AU AU43265/99A patent/AU4326599A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2332534A1 (fr) | 1999-12-02 |
| EP1090412A1 (fr) | 2001-04-11 |
| JP2002517070A (ja) | 2002-06-11 |
| WO1999062101A9 (fr) | 2000-03-02 |
| AU4326599A (en) | 1999-12-13 |
| WO1999062101A1 (fr) | 1999-12-02 |
| CA2626383A1 (fr) | 1999-12-02 |
| EP1090412B1 (fr) | 2014-03-05 |
| EP1090412A4 (fr) | 2006-01-25 |
| CA2626383C (fr) | 2011-07-19 |
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Effective date: 20190529 |