CA2601623C - Methods and compositions for evaluating graft survival in a solid organ transplant recipient - Google Patents
Methods and compositions for evaluating graft survival in a solid organ transplant recipient Download PDFInfo
- Publication number
- CA2601623C CA2601623C CA2601623A CA2601623A CA2601623C CA 2601623 C CA2601623 C CA 2601623C CA 2601623 A CA2601623 A CA 2601623A CA 2601623 A CA2601623 A CA 2601623A CA 2601623 C CA2601623 C CA 2601623C
- Authority
- CA
- Canada
- Prior art keywords
- methods
- compositions
- graft survival
- organ transplant
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66208305P | 2005-03-14 | 2005-03-14 | |
| US60/662,083 | 2005-03-14 | ||
| PCT/US2006/009134 WO2006099421A2 (en) | 2005-03-14 | 2006-03-13 | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2601623A1 CA2601623A1 (en) | 2006-09-21 |
| CA2601623C true CA2601623C (en) | 2018-10-23 |
Family
ID=36992379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2601623A Expired - Lifetime CA2601623C (en) | 2005-03-14 | 2006-03-13 | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7741038B2 (enExample) |
| EP (2) | EP1869213A4 (enExample) |
| JP (2) | JP2008537875A (enExample) |
| CA (1) | CA2601623C (enExample) |
| WO (1) | WO2006099421A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002950779A0 (en) * | 2002-08-15 | 2002-09-12 | The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland | A method of immunomodulation |
| US8932808B1 (en) * | 2004-01-21 | 2015-01-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for determining a graft tolerant phenotype in a subject |
| USRE46843E1 (en) | 2005-03-14 | 2018-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
| WO2006099421A2 (en) | 2005-03-14 | 2006-09-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
| EP2066809A2 (en) * | 2006-08-28 | 2009-06-10 | Source Precision Medicine | Gene expression profiling for identification, monitoring and treatment of transplant rejection |
| US8003333B2 (en) * | 2007-09-28 | 2011-08-23 | Mayo Foundation For Medical Education And Research | Serum biomarkers for early detection of acute cellular rejection |
| EP2088205A1 (en) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
| ES2341419B1 (es) * | 2008-08-14 | 2011-05-03 | Hospital Clinic I Provincial De Barcelona | Wnt1 como biomarcador de daño renal. |
| US20110201519A1 (en) | 2008-08-18 | 2011-08-18 | Sarwal Minnie M | Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject |
| BRPI0917711A2 (pt) * | 2008-08-28 | 2017-06-20 | Astute Medical Inc | método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal |
| WO2010025434A1 (en) * | 2008-08-29 | 2010-03-04 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN104076152B (zh) * | 2008-10-21 | 2017-04-19 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| CN106370857A (zh) | 2008-10-21 | 2017-02-01 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| JP5752600B2 (ja) | 2008-11-10 | 2015-07-22 | アスチュート メディカル,インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法 |
| CN103439510B (zh) * | 2008-11-22 | 2016-09-14 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| CN102439172B (zh) * | 2009-01-15 | 2017-03-01 | 小利兰·斯坦福大学托管委员会 | 用于诊断和预测移植物排斥的生物标志物板 |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2767616A1 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| US8871459B2 (en) | 2009-08-07 | 2014-10-28 | Astute Medical, Inc. | Method for evaluating renal status by determining beta-2-glycoprotein 1 |
| NZ599773A (en) | 2009-11-07 | 2014-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011066380A1 (en) * | 2009-11-25 | 2011-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers for the diagnosis of kidney graft rejection |
| EP3185013B1 (en) | 2009-12-02 | 2019-10-09 | The Board of Trustees of the Leland Stanford Junior University | Biomarkers for determining an allograft tolerant phenotype |
| CN102725636B (zh) | 2009-12-20 | 2015-04-01 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
| CA2788826C (en) | 2010-02-05 | 2023-09-26 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011162819A1 (en) * | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2539712A4 (en) | 2010-02-26 | 2013-09-18 | Astute Medical Inc | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE |
| US9535075B2 (en) | 2010-03-25 | 2017-01-03 | The Board Of Trustees Of The Leland Stanford Junior University | Protein and gene biomarkers for rejection of organ transplants |
| GB201007454D0 (en) * | 2010-05-04 | 2010-06-16 | King S College London | Method of determining tolerance |
| CA2803500A1 (en) * | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20130210043A1 (en) * | 2010-06-23 | 2013-08-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2012106632A1 (en) * | 2011-02-03 | 2012-08-09 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers for determining an allograft tolerant phenotype |
| WO2012139051A2 (en) | 2011-04-06 | 2012-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Autoantibody biomarkers for iga nephropathy |
| CN103958662A (zh) * | 2011-10-24 | 2014-07-30 | 私募蛋白质体公司 | 用于疾病生物标记鉴定和样品质量评价的优选样品处理和加工方案的选择 |
| WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP6681195B2 (ja) | 2013-01-17 | 2020-04-15 | アスチュート メディカル,インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| WO2015035177A1 (en) * | 2013-09-06 | 2015-03-12 | Immucor Gti Diagnostics, Inc. | Compositions and methods for diagnosis and prediction of solid organ graft rejection |
| CN103675300B (zh) * | 2014-01-03 | 2015-10-14 | 苏州工业园区为真生物医药科技有限公司 | Rbx1作为血清标志物的应用及其试剂盒 |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| CN109844526A (zh) | 2016-06-06 | 2019-06-04 | 机敏医药股份有限公司 | 使用胰岛素样生长因子结合蛋白7和金属蛋白酶2的组织抑制剂管理急性肾损伤 |
| US10894960B2 (en) | 2016-08-30 | 2021-01-19 | Children's Hospital Medical Center | Compositions and methods for nucleic acid transfer |
| WO2018046615A1 (en) * | 2016-09-08 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting chronic lung allograft dysfunction |
| US11346846B2 (en) | 2017-02-06 | 2022-05-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US12411144B2 (en) | 2017-03-22 | 2025-09-09 | Children's Hospital Medical Center | Compositions and methods for treatment of lung function |
| WO2019107673A1 (ko) * | 2017-11-29 | 2019-06-06 | 서울대학교병원 | Abo 혈액형 부적합 이식시의 항체-매개성 거부반응의 모니터링을 위한 바이오마커 |
| WO2021072000A1 (en) | 2019-10-08 | 2021-04-15 | Children's Hospital Medical Center | Serum protein biomarker panel for idiopathic pulmonary fibrosis |
| CN111593113A (zh) * | 2020-05-21 | 2020-08-28 | 中国科学院大学宁波华美医院 | 一种基于急性排斥反应新机制的vegf基因结合位点检测方法 |
| US12247978B2 (en) * | 2020-08-05 | 2025-03-11 | Arizona Board Of Regents On Behalf Of Northern Arizona University | Compositions and methods for detection and treatment of coronavirus infection |
| WO2022031877A1 (en) * | 2020-08-05 | 2022-02-10 | Children's Hospital Medical Center | Compositions and methods for the treatment of bronchiolitis obliterans |
| CN111939272B (zh) * | 2020-08-21 | 2023-02-24 | 上海交通大学医学院附属第九人民医院 | Ccn1的用途 |
| CN116042848B (zh) * | 2021-10-28 | 2024-08-09 | 北京干细胞与再生医学研究院 | 一种通过血样检测判断动物体内存在移植物的方法 |
| CN116486922B (zh) * | 2023-04-18 | 2024-01-23 | 中日友好医院(中日友好临床医学研究所) | 一种基于基因多态性及血浆细胞因子的肺移植排斥预测方法及应用 |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| DE69322266T2 (de) | 1992-04-03 | 1999-06-02 | Perkin-Elmer Corp., Foster City, Calif. | Proben zusammensetzung und verfahren |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| JP2002515738A (ja) | 1996-01-23 | 2002-05-28 | アフィメトリックス,インコーポレイティド | 核酸分析法 |
| WO1997029212A1 (en) | 1996-02-08 | 1997-08-14 | Affymetrix, Inc. | Chip-based speciation and phenotypic characterization of microorganisms |
| US5994076A (en) | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| WO1999005574A1 (en) | 1997-07-25 | 1999-02-04 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
| US20030104371A1 (en) * | 1997-09-24 | 2003-06-05 | Strom Terry B. | Methods of evaluating transplant rejection |
| JP4584447B2 (ja) | 1997-11-07 | 2010-11-24 | トリリアム・セラピューティクス・インコーポレイテッド | 免疫調節のための方法および組成物 |
| US6607879B1 (en) | 1998-02-09 | 2003-08-19 | Incyte Corporation | Compositions for the detection of blood cell and immunological response gene expression |
| DE69938780D1 (de) | 1998-03-31 | 2008-07-03 | Asahi Kasei Pharma Corp | VERFAHREN ZUR UNTERSUCHUNG DER IgA-NEPHROPATHIE |
| US20050025769A1 (en) | 1999-01-22 | 2005-02-03 | Fujisawa Pharmaceutical Company, Ltd. | Method of suppressing ongoing acute allograft rejection |
| HUP0303930A3 (en) | 2001-01-26 | 2012-09-28 | Univ Emory | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
| WO2002092124A1 (en) | 2001-05-11 | 2002-11-21 | Wyeth | Methods for diagnosing and treating ischemia and reperfusion injury and compositions thereof |
| US7235358B2 (en) | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US20030022252A1 (en) | 2001-07-13 | 2003-01-30 | Thomson Angus W. | Method for identifying tolerance in graft recipients |
| US20070134261A1 (en) | 2001-12-03 | 2007-06-14 | Hancock Robert E | Effectors of innate immunity |
| AU2003291134A1 (en) * | 2002-11-21 | 2004-06-18 | Genzyme Corporation | Use of diamide derivatives for inhibiting chronic tissue transplant rejection |
| WO2004074815A2 (en) * | 2003-02-14 | 2004-09-02 | Beth Israel Deaconess Medical Center, Inc. | Predicting graft rejection |
| US7892745B2 (en) | 2003-04-24 | 2011-02-22 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| CA2528669A1 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| EP1718327B1 (en) | 2003-06-20 | 2015-01-07 | University of Florida | Biomarkers for differentiating between type 1 and type 2 diabetes |
| JP4316617B2 (ja) | 2003-12-03 | 2009-08-19 | ノバルティス アクチエンゲゼルシャフト | 移植片拒絶反応のバイオマーカー |
| US8932808B1 (en) | 2004-01-21 | 2015-01-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for determining a graft tolerant phenotype in a subject |
| WO2005074540A2 (en) | 2004-01-30 | 2005-08-18 | University Of Pennsylvania | Novel predictors of transplant rejection determined by peripheral blood gene-expression profiling |
| WO2006033664A1 (en) | 2004-03-08 | 2006-03-30 | Avalon Pharmaceuticals | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
| CA2560311A1 (en) | 2004-04-08 | 2005-10-20 | Novartis Ag | Protein kinase c inhibitors for the treatment of autoimmune diseases and of transplant rejection |
| WO2006014755A2 (en) | 2004-07-20 | 2006-02-09 | Wyeth | Methods of identifying patients at risk of developing encephalitis following immunotherapy for alzheimer’s disease |
| US20080280282A1 (en) | 2004-08-03 | 2008-11-13 | Bauer Jr A Robert | Method for early detection of various cancers and gastrointestinal disease and monitoring of transplanted organs |
| US7820382B2 (en) | 2004-08-03 | 2010-10-26 | Bauer A Robert | Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation |
| WO2006099421A2 (en) | 2005-03-14 | 2006-09-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
| US7666596B2 (en) | 2005-05-23 | 2010-02-23 | University Of Alberta | Tissue rejection |
| EP1909810B2 (en) | 2005-06-07 | 2017-08-23 | The Regents of the University of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival |
| EP1731620A1 (en) | 2005-06-07 | 2006-12-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for the diagnosis of immune graft tolerance |
| AU2006254834B2 (en) | 2005-06-08 | 2012-09-20 | Millennium Pharmaceuticals, Inc. | Treatment of patients with cancer therapy |
| WO2007050588A2 (en) | 2005-10-25 | 2007-05-03 | Renovar Incorporated | Systems and methods for characterizing conditions of organs for transplantation |
| WO2007091254A1 (en) | 2006-02-06 | 2007-08-16 | Rappaport Family Institute For Research In The Medical Sciences | Methods and kit for diagnosing t1dm |
| GB0605217D0 (en) | 2006-03-15 | 2006-04-26 | Novartis Ag | Method and compositions for assessing acute rejection |
| WO2007112097A2 (en) | 2006-03-24 | 2007-10-04 | Children's Medical Center Corporation | Novel signature self renewal gene expression programs |
| GB0607943D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Biomarkers for chronic transplant dysfunction |
| CA2650507A1 (en) | 2006-04-27 | 2007-11-08 | Universite De Montreal | Assessment and reduction of risk of graft-versus-host disease |
| WO2008084331A2 (en) | 2006-06-21 | 2008-07-17 | Hopitaux Universitaires De Geneve | Biomarkers for renal disorders |
| WO2008009132A1 (en) | 2006-07-21 | 2008-01-24 | The Governors Of The University Of Alberta | Tissue rejection |
| EP2066809A2 (en) | 2006-08-28 | 2009-06-10 | Source Precision Medicine | Gene expression profiling for identification, monitoring and treatment of transplant rejection |
| ES2324751B1 (es) | 2007-01-04 | 2010-05-31 | Institut D'investigacions Biomediques August Pi I Sunyer (Idibaps) | Metodos y kits para diagnosticar y/o pronosticar el estado de tolerancia en el trasplante de higado. |
| US20090155784A1 (en) | 2007-01-22 | 2009-06-18 | Wyeth | Assessment of asthma and allergen-dependent gene expression |
| JP2010524456A (ja) | 2007-04-16 | 2010-07-22 | イプソゲン | 乳癌に罹患している雌哺乳動物に対する臨床転帰の傾向を評価する方法 |
| WO2009044899A1 (ja) | 2007-10-03 | 2009-04-09 | Kyowa Hakko Kirin Co., Ltd. | 細胞の増殖を制御する核酸 |
| JP2011517939A (ja) | 2008-04-09 | 2011-06-23 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 急性心臓同種移植拒絶反応を診断する方法 |
| KR20110020853A (ko) | 2008-05-30 | 2011-03-03 | 더 유니버시티 오브 브리티시 콜롬비아 | 유전자 또는 단백질 발현 프로파일을 이용한 신장 동종이식 거부반응 진단방법 |
| KR101644120B1 (ko) | 2008-06-02 | 2016-07-29 | 에디아 가부시키가이샤 | IgA 신증의 검사 방법 및 검사 키트 |
| US20110201519A1 (en) | 2008-08-18 | 2011-08-18 | Sarwal Minnie M | Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject |
| KR100928403B1 (ko) | 2008-10-01 | 2009-11-26 | 경북대학교 산학협력단 | 티지비엠 신증의 진단용 조성물 및 키트 |
| CN102439172B (zh) | 2009-01-15 | 2017-03-01 | 小利兰·斯坦福大学托管委员会 | 用于诊断和预测移植物排斥的生物标志物板 |
| US8734786B2 (en) | 2009-09-16 | 2014-05-27 | Northwestern University | Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection |
| EP2569630A4 (en) | 2010-05-13 | 2013-10-30 | Univ New Jersey Med | DIAGNOSTIC AUTOANTIKÖRPER PROFILES FOR THE DETECTION AND DIAGNOSIS OF NEURODEGENERATIVE DISEASES |
-
2006
- 2006-03-13 WO PCT/US2006/009134 patent/WO2006099421A2/en not_active Ceased
- 2006-03-13 US US11/375,681 patent/US7741038B2/en not_active Ceased
- 2006-03-13 EP EP06738217A patent/EP1869213A4/en not_active Withdrawn
- 2006-03-13 CA CA2601623A patent/CA2601623C/en not_active Expired - Lifetime
- 2006-03-13 JP JP2008501966A patent/JP2008537875A/ja active Pending
- 2006-03-13 EP EP12197040.4A patent/EP2604703B1/en not_active Expired - Lifetime
-
2012
- 2012-06-21 US US13/529,768 patent/USRE47057E1/en active Active
-
2015
- 2015-03-23 JP JP2015059131A patent/JP6178356B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006099421A2 (en) | 2006-09-21 |
| EP2604703A3 (en) | 2013-09-18 |
| WO2006099421A3 (en) | 2007-03-01 |
| JP2008537875A (ja) | 2008-10-02 |
| EP2604703A2 (en) | 2013-06-19 |
| USRE47057E1 (en) | 2018-09-25 |
| US20060246485A1 (en) | 2006-11-02 |
| US7741038B2 (en) | 2010-06-22 |
| EP2604703B1 (en) | 2017-02-01 |
| CA2601623A1 (en) | 2006-09-21 |
| EP1869213A2 (en) | 2007-12-26 |
| JP6178356B2 (ja) | 2017-08-09 |
| EP1869213A4 (en) | 2008-05-14 |
| JP2015154774A (ja) | 2015-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2006099421A3 (en) | Methods and compositions for evaluating graft survival in a solid organ transplant recipient | |
| EP4484571A3 (en) | Methods and compositions for integrated in situ spatial assay | |
| WO2003106964A3 (en) | High throughput methods and devices for assaying analytes in a fluid sample | |
| WO2003093494A3 (en) | Apparatus including ion transport detecting structures and methods of use | |
| WO2002077259A3 (en) | Biochips including ion transport detecting structures and methods of use | |
| EP1379693A4 (en) | BIO STICK CODES BASED ON OLIGONUCLEOTIDE-MODIFIED PARTICLES | |
| DE602007011937D1 (de) | Peptidantikörperdepletion und anwendung zur probenvorbereitung für massenspektrometrie | |
| AU2002350779A1 (en) | Analyzer and analysing method and a fluid cartridge | |
| WO2007080583A3 (en) | Methods and systems for analyzing biological samples | |
| WO2007098279A3 (en) | Analyte detection using barcoded polymers | |
| WO2003048300A3 (en) | Methods of identifying cellular target molecules | |
| WO2008066629A3 (en) | Methods for quantitative proteome analysis of glycoproteins | |
| ATE541054T1 (de) | Bio-barcode erkennung für zielmoleküle | |
| IL188460A0 (en) | Diagnostic methods and compositions for diagnosing and treating influenza | |
| DE60332948D1 (de) | Strategien zur genexpressionsanalyse | |
| WO2007103374A3 (en) | Toxicity screening methods | |
| WO2004051218A8 (en) | Multiplex amplification of polynucleotides | |
| WO2010047779A3 (en) | Integrated bioanalyzer | |
| ATE556030T1 (de) | Ultrasensitiver nachweis von analyten | |
| ATE510212T1 (de) | Reagenz zur analyse unreifer leukozyten und reagenzkit | |
| WO2005067692A3 (en) | Detection and quantification of analytes in solution using polymers | |
| WO2007114986A3 (en) | Cooperative probes and methods of using them | |
| DE602004021185D1 (de) | Auf bio-barcodes beruhender nachweis von zielanalyten | |
| WO2007035929A3 (en) | Method for detecting and quantitating multiple subcellular components | |
| WO2003014697A3 (en) | Amplification of analyte detection with passivated enhancing surfaces having receptors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| H11 | Ip right ceased following rejected request for revival |
Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED Effective date: 20250915 |
|
| H13 | Ip right lapsed |
Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE Effective date: 20251106 |