CA2601623C - Methods and compositions for evaluating graft survival in a solid organ transplant recipient - Google Patents

Methods and compositions for evaluating graft survival in a solid organ transplant recipient Download PDF

Info

Publication number
CA2601623C
CA2601623C CA2601623A CA2601623A CA2601623C CA 2601623 C CA2601623 C CA 2601623C CA 2601623 A CA2601623 A CA 2601623A CA 2601623 A CA2601623 A CA 2601623A CA 2601623 C CA2601623 C CA 2601623C
Authority
CA
Canada
Prior art keywords
methods
compositions
graft survival
organ transplant
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2601623A
Other languages
English (en)
French (fr)
Other versions
CA2601623A1 (en
Inventor
Minnie M. Sarwal
Elaine Mansfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CA2601623A1 publication Critical patent/CA2601623A1/en
Application granted granted Critical
Publication of CA2601623C publication Critical patent/CA2601623C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2601623A 2005-03-14 2006-03-13 Methods and compositions for evaluating graft survival in a solid organ transplant recipient Expired - Lifetime CA2601623C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66208305P 2005-03-14 2005-03-14
US60/662,083 2005-03-14
PCT/US2006/009134 WO2006099421A2 (en) 2005-03-14 2006-03-13 Methods and compositions for evaluating graft survival in a solid organ transplant recipient

Publications (2)

Publication Number Publication Date
CA2601623A1 CA2601623A1 (en) 2006-09-21
CA2601623C true CA2601623C (en) 2018-10-23

Family

ID=36992379

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2601623A Expired - Lifetime CA2601623C (en) 2005-03-14 2006-03-13 Methods and compositions for evaluating graft survival in a solid organ transplant recipient

Country Status (5)

Country Link
US (2) US7741038B2 (enExample)
EP (2) EP2604703B1 (enExample)
JP (2) JP2008537875A (enExample)
CA (1) CA2601623C (enExample)
WO (1) WO2006099421A2 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002950779A0 (en) * 2002-08-15 2002-09-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland A method of immunomodulation
CA2553551C (en) * 2004-01-21 2020-12-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
EP2604703B1 (en) 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Methods for evaluating graft survival in a solid organ transplant recipient
USRE46843E1 (en) 2005-03-14 2018-05-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
US20080233573A1 (en) * 2006-08-28 2008-09-25 Kathleen Storm Gene expression profiling for identification, monitoring and treatment of transplant rejection
US8003333B2 (en) * 2007-09-28 2011-08-23 Mayo Foundation For Medical Education And Research Serum biomarkers for early detection of acute cellular rejection
EP2088205A1 (en) 2008-02-11 2009-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) PSMB10: A diagnosis marker and therapeutic target of chronic rejection.
ES2341419B1 (es) * 2008-08-14 2011-05-03 Hospital Clinic I Provincial De Barcelona Wnt1 como biomarcador de daño renal.
WO2010021696A1 (en) * 2008-08-18 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
BRPI0917711A2 (pt) * 2008-08-28 2017-06-20 Astute Medical Inc método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal
EP2324354B1 (en) * 2008-08-29 2014-07-16 Astute Medical, Inc. Methods for prognosis of acute renal failure
NZ619918A (en) * 2008-10-21 2015-04-24 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104391115B (zh) * 2008-10-21 2017-04-19 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
BRPI0922021A2 (pt) 2008-11-10 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal
CN104034901A (zh) * 2008-11-22 2014-09-10 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
ES2492498T3 (es) * 2009-01-15 2014-09-09 The Board Of Trustees Of The Leland Stanford Junior University Panel de biomarcadores para el diagnóstico y la predicción de rechazo de injerto
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
JP5827226B2 (ja) 2009-08-07 2015-12-02 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
MX340078B (es) 2009-11-07 2016-06-24 Astute Medical Inc Metodos y composiciones para el diagnostico y pronostico de daño renal y falla renal.
WO2011066380A1 (en) * 2009-11-25 2011-06-03 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for the diagnosis of kidney graft rejection
US9290813B2 (en) 2009-12-02 2016-03-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
KR20120123056A (ko) 2009-12-20 2012-11-07 아스튜트 메디컬 인코포레이티드 신손상 및 신부전을 진단 및 예측하는 방법 및 조성물
EP2531620B1 (en) 2010-02-05 2016-12-14 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011269847A1 (en) * 2010-02-26 2013-01-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2539712A4 (en) 2010-02-26 2013-09-18 Astute Medical Inc METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
CA2794255C (en) * 2010-03-25 2020-01-14 The Board Of Trustees Of The Leland Stanford Junior University Protein and gene biomarkers for rejection of organ transplants
GB201007454D0 (en) * 2010-05-04 2010-06-16 King S College London Method of determining tolerance
EP2585827A4 (en) 2010-06-23 2013-12-04 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
MX2013000220A (es) * 2010-06-23 2013-03-22 Astute Medical Inc Metodos y composiciones para diagnóstico y pronóstico de lesión renal e insuficiencia renal.
US20130210043A1 (en) * 2010-06-23 2013-08-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2012106632A1 (en) * 2011-02-03 2012-08-09 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
WO2012139051A2 (en) 2011-04-06 2012-10-11 The Board Of Trustees Of The Leland Stanford Junior University Autoantibody biomarkers for iga nephropathy
AU2012328864A1 (en) * 2011-10-24 2014-04-17 Somalogic, Inc. Selection of preferred sample handling and processing protocol for identification of disease biomarkers and sample quality assessment
WO2013086359A1 (en) 2011-12-08 2013-06-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2681955T3 (es) 2013-01-17 2018-09-17 Astute Medical, Inc. Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
EP3041955A4 (en) * 2013-09-06 2017-05-03 Immucor GTI Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
CN103675300B (zh) * 2014-01-03 2015-10-14 苏州工业园区为真生物医药科技有限公司 Rbx1作为血清标志物的应用及其试剂盒
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
AU2017277305A1 (en) 2016-06-06 2018-12-20 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
US10894960B2 (en) 2016-08-30 2021-01-19 Children's Hospital Medical Center Compositions and methods for nucleic acid transfer
PT3510167T (pt) * 2016-09-08 2021-10-18 Inst Nat Sante Rech Med Métodos e composições para prever disfunção crónica de aloenxerto pulmonar
US11346846B2 (en) 2017-02-06 2022-05-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US12411144B2 (en) 2017-03-22 2025-09-09 Children's Hospital Medical Center Compositions and methods for treatment of lung function
WO2019107673A1 (ko) * 2017-11-29 2019-06-06 서울대학교병원 Abo 혈액형 부적합 이식시의 항체-매개성 거부반응의 모니터링을 위한 바이오마커
CN111593113A (zh) * 2020-05-21 2020-08-28 中国科学院大学宁波华美医院 一种基于急性排斥反应新机制的vegf基因结合位点检测方法
WO2022031877A1 (en) * 2020-08-05 2022-02-10 Children's Hospital Medical Center Compositions and methods for the treatment of bronchiolitis obliterans
US20230330121A1 (en) * 2020-08-05 2023-10-19 Children's Hospital Medical Center Compositions and methods for the treatment of bronchiolitis obliterans
CN111939272B (zh) * 2020-08-21 2023-02-24 上海交通大学医学院附属第九人民医院 Ccn1的用途
CN116042848B (zh) * 2021-10-28 2024-08-09 北京干细胞与再生医学研究院 一种通过血样检测判断动物体内存在移植物的方法
CN116486922B (zh) * 2023-04-18 2024-01-23 中日友好医院(中日友好临床医学研究所) 一种基于基因多态性及血浆细胞因子的肺移植排斥预测方法及应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0430881A3 (en) 1989-11-29 1991-10-23 Ciba-Geigy Ag Photochromic compounds, process for their preparation and their use
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
WO1993020236A1 (en) 1992-04-03 1993-10-14 Applied Biosystems, Inc. Probe composition and method
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
US6228575B1 (en) 1996-02-08 2001-05-08 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
WO1999005591A2 (en) 1997-07-25 1999-02-04 Affymetrix, Inc. Method and apparatus for providing a bioinformatics database
US20030104371A1 (en) 1997-09-24 2003-06-05 Strom Terry B. Methods of evaluating transplant rejection
JP4584447B2 (ja) 1997-11-07 2010-11-24 トリリアム・セラピューティクス・インコーポレイテッド 免疫調節のための方法および組成物
US6607879B1 (en) 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
EP1069432B1 (en) 1998-03-31 2008-05-21 Asahi Kasei Pharma Corporation METHOD FOR EXAMINING IgA NEPHROPATHY
US20050025769A1 (en) 1999-01-22 2005-02-03 Fujisawa Pharmaceutical Company, Ltd. Method of suppressing ongoing acute allograft rejection
CA2436139A1 (en) 2001-01-26 2002-08-01 Emory University Methods of inducing organ transplant tolerance and correcting hemoglobinopathies
WO2002092124A1 (en) 2001-05-11 2002-11-21 Wyeth Methods for diagnosing and treating ischemia and reperfusion injury and compositions thereof
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
WO2003005972A2 (en) 2001-07-13 2003-01-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Method for identifying tolerance in graft recipients
US20070134261A1 (en) 2001-12-03 2007-06-14 Hancock Robert E Effectors of innate immunity
DE60335652D1 (de) 2002-11-21 2011-02-17 Genzyme Corp Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung
AU2004213839B2 (en) * 2003-02-14 2010-08-12 Beth Israel Deaconess Medical Center, Inc. Predicting graft rejection
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
EP2003196A3 (en) 2003-06-09 2009-01-07 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
US7648825B2 (en) 2003-06-20 2010-01-19 University Of Florida Research Foundation, Inc. Biomarkers for differentiating between type 1 and type 2 diabetes
EP1694860A2 (en) 2003-12-03 2006-08-30 Novartis AG Biomarkers for graft rejection
CA2553551C (en) 2004-01-21 2020-12-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
WO2005074540A2 (en) 2004-01-30 2005-08-18 University Of Pennsylvania Novel predictors of transplant rejection determined by peripheral blood gene-expression profiling
WO2006033664A1 (en) 2004-03-08 2006-03-30 Avalon Pharmaceuticals Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods
US20070232658A1 (en) 2004-04-08 2007-10-04 Jurgen Wagner Protein Kinase C Inhibitors for the Treatment of Autoimmune Diseases and of Transplant Rejiction
WO2006014755A2 (en) 2004-07-20 2006-02-09 Wyeth Methods of identifying patients at risk of developing encephalitis following immunotherapy for alzheimer’s disease
US7820382B2 (en) 2004-08-03 2010-10-26 Bauer A Robert Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US20080280282A1 (en) 2004-08-03 2008-11-13 Bauer Jr A Robert Method for early detection of various cancers and gastrointestinal disease and monitoring of transplanted organs
EP2604703B1 (en) 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Methods for evaluating graft survival in a solid organ transplant recipient
US7666596B2 (en) 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
ES2516690T5 (es) 2005-06-07 2017-11-21 The Regents Of The University Of Colorado, A Body Corporate Inhibidores de la actividad de serina proteasa y su uso en métodos y composiciones para el tratamiento de rechazo de injertos y promoción de supervivencia de injertos
EP1731620A1 (en) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for the diagnosis of immune graft tolerance
ES2624863T3 (es) 2005-06-08 2017-07-17 Millennium Pharmaceuticals, Inc. Métodos para identificación, evaluación, y tratamiento de pacientes con terapia de cáncer
US20070134728A1 (en) 2005-10-25 2007-06-14 Renovar Incorporated Systems and methods for characterizing conditions and diseases associated with organ transplantation and organ health
EP1989554A1 (en) 2006-02-06 2008-11-12 Rappaport Family Institute For Research in the Medical Sciences Methods and kit for diagnosing t1dm
GB0605217D0 (en) 2006-03-15 2006-04-26 Novartis Ag Method and compositions for assessing acute rejection
WO2007112097A2 (en) 2006-03-24 2007-10-04 Children's Medical Center Corporation Novel signature self renewal gene expression programs
GB0607943D0 (en) 2006-04-21 2006-05-31 Novartis Ag Biomarkers for chronic transplant dysfunction
WO2007124578A1 (en) 2006-04-27 2007-11-08 Universite De Montreal Assessment and reduction of risk of graft-versus-host disease
WO2008084331A2 (en) 2006-06-21 2008-07-17 Hopitaux Universitaires De Geneve Biomarkers for renal disorders
EP2049713A4 (en) 2006-07-21 2010-06-16 Univ Alberta tissue rejection
US20080233573A1 (en) 2006-08-28 2008-09-25 Kathleen Storm Gene expression profiling for identification, monitoring and treatment of transplant rejection
ES2324751B1 (es) 2007-01-04 2010-05-31 Institut D'investigacions Biomediques August Pi I Sunyer (Idibaps) Metodos y kits para diagnosticar y/o pronosticar el estado de tolerancia en el trasplante de higado.
US20090155784A1 (en) 2007-01-22 2009-06-18 Wyeth Assessment of asthma and allergen-dependent gene expression
US20100234292A1 (en) 2007-04-16 2010-09-16 Ipsogen Methods of assessing a propensity of clinical outcome for a female mammal suffering from breast cancer
WO2009044899A1 (ja) 2007-10-03 2009-04-09 Kyowa Hakko Kirin Co., Ltd. 細胞の増殖を制御する核酸
AU2009235925A1 (en) 2008-04-09 2009-10-15 The University Of British Columbia Methods of diagnosing acute cardiac allograft rejection
AU2009253696A1 (en) 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
ES2402483T3 (es) 2008-06-02 2013-05-06 Eisai R&D Management Co., Ltd. Método de detección y kit de detección de nefropatía por lgA
WO2010021696A1 (en) 2008-08-18 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
KR100928403B1 (ko) 2008-10-01 2009-11-26 경북대학교 산학협력단 티지비엠 신증의 진단용 조성물 및 키트
ES2492498T3 (es) 2009-01-15 2014-09-09 The Board Of Trustees Of The Leland Stanford Junior University Panel de biomarcadores para el diagnóstico y la predicción de rechazo de injerto
US8734786B2 (en) 2009-09-16 2014-05-27 Northwestern University Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection
AU2011253385B2 (en) 2010-05-13 2016-11-03 Rowan University Diagnostic autoantibody profiles for the detection and diagnosis of neurodegenerative diseases

Also Published As

Publication number Publication date
EP1869213A2 (en) 2007-12-26
JP6178356B2 (ja) 2017-08-09
EP2604703A2 (en) 2013-06-19
CA2601623A1 (en) 2006-09-21
US7741038B2 (en) 2010-06-22
US20060246485A1 (en) 2006-11-02
USRE47057E1 (en) 2018-09-25
EP2604703A3 (en) 2013-09-18
WO2006099421A2 (en) 2006-09-21
EP1869213A4 (en) 2008-05-14
JP2008537875A (ja) 2008-10-02
EP2604703B1 (en) 2017-02-01
WO2006099421A3 (en) 2007-03-01
JP2015154774A (ja) 2015-08-27

Similar Documents

Publication Publication Date Title
CA2601623C (en) Methods and compositions for evaluating graft survival in a solid organ transplant recipient
EP4484571A3 (en) Methods and compositions for integrated in situ spatial assay
Wu et al. Impact of alloantibody strength in crossmatch negative DSA positive kidney transplantation
WO2003093494A3 (en) Apparatus including ion transport detecting structures and methods of use
EP1362929A3 (en) Methods for genotyping
WO2002077259A3 (en) Biochips including ion transport detecting structures and methods of use
EP1379693A4 (en) BIO STICK CODES BASED ON OLIGONUCLEOTIDE-MODIFIED PARTICLES
DE602007011937D1 (de) Peptidantikörperdepletion und anwendung zur probenvorbereitung für massenspektrometrie
AU2002350779A1 (en) Analyzer and analysing method and a fluid cartridge
WO2003048300A3 (en) Methods of identifying cellular target molecules
WO2008066629A3 (en) Methods for quantitative proteome analysis of glycoproteins
IL188460A0 (en) Diagnostic methods and compositions for diagnosing and treating influenza
WO2007103374A3 (en) Toxicity screening methods
WO2004051218A3 (en) Multiplex amplification of polynucleotides
ATE510212T1 (de) Reagenz zur analyse unreifer leukozyten und reagenzkit
WO2005067692A3 (en) Detection and quantification of analytes in solution using polymers
WO2006078289A3 (en) Bio-barcode based detection of target analytes
WO2005003394A3 (en) Bio-barcode based detection of target analytes
WO2007085827A3 (en) Epigenetic analyses
WO2003014697A3 (en) Amplification of analyte detection with passivated enhancing surfaces having receptors
DE60234461D1 (de) Nukleinsäuren zur identifizierung von pilzen und verfahren zu deren verwendung
WO2005054516A3 (en) Peptide nucleic acid probes for analysis of certain staphylococcus species
WO2006007403A3 (en) Methods for identifying and measuring s-nitrosothiol bonds in heme-containing cells and molecules
FI20040255A7 (fi) Menetelmä pre-eklampsian riskin havaitsemiseksi
WO2005095653A3 (en) Method for collecting purified cells

Legal Events

Date Code Title Description
EEER Examination request