CA2598831A1 - Procedes de traitement d'inflammation gastro-intestinale - Google Patents
Procedes de traitement d'inflammation gastro-intestinale Download PDFInfo
- Publication number
- CA2598831A1 CA2598831A1 CA002598831A CA2598831A CA2598831A1 CA 2598831 A1 CA2598831 A1 CA 2598831A1 CA 002598831 A CA002598831 A CA 002598831A CA 2598831 A CA2598831 A CA 2598831A CA 2598831 A1 CA2598831 A1 CA 2598831A1
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- agonist
- type
- interferon
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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US65545505P | 2005-02-22 | 2005-02-22 | |
US60/655,455 | 2005-02-22 | ||
PCT/US2006/006095 WO2006091591A1 (fr) | 2005-02-22 | 2006-02-21 | Procedes de traitement d'inflammation gastro-intestinale |
Publications (1)
Publication Number | Publication Date |
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CA2598831A1 true CA2598831A1 (fr) | 2006-08-31 |
Family
ID=36927747
Family Applications (1)
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CA002598831A Abandoned CA2598831A1 (fr) | 2005-02-22 | 2006-02-21 | Procedes de traitement d'inflammation gastro-intestinale |
Country Status (7)
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US (1) | US7560436B2 (fr) |
EP (1) | EP1858326A4 (fr) |
JP (1) | JP2008531502A (fr) |
AU (1) | AU2006216822A1 (fr) |
CA (1) | CA2598831A1 (fr) |
IL (1) | IL185396A0 (fr) |
WO (1) | WO2006091591A1 (fr) |
Families Citing this family (26)
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US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
ES2487645T3 (es) * | 2001-06-21 | 2014-08-22 | Dynavax Technologies Corporation | Compuestos inmunomoduladores quiméricos y métodos de uso de los mismos |
AU2002366710A1 (en) * | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
US8518903B2 (en) | 2007-04-19 | 2013-08-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Use of toll-like receptor-9 agonists |
CA2699190A1 (fr) * | 2007-04-19 | 2009-10-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Utilisation d'agonistes du recepteur 9 de type toll (tlr9), d'antagonistes du recepteur 4 de type toll (tlr4), et/ou d'agonistes du domaine 2 d'oligomerisation nucleaire (nod2) pour le traitement ou la prevention de troubles associes au recepteur 4 de type toll |
GB0715428D0 (en) * | 2007-08-08 | 2007-09-19 | Imp Innovations Ltd | Compositions and uses thereof |
MX2011010050A (es) | 2009-03-25 | 2011-12-14 | Univ Texas | Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos. |
JP2012523379A (ja) | 2009-04-09 | 2012-10-04 | ザ ユニバーシティー オブ メルボルン | 免疫原性組成物およびその使用 |
US8367316B2 (en) | 2009-05-01 | 2013-02-05 | Alfagene Bioscience, Inc. | Human gastrointestinal stem cell-derived primary intestinal epithelial cell system and methods of use thereof |
CA2774999A1 (fr) | 2009-09-30 | 2011-04-07 | President And Fellows Of Harvard College | Procedes de modulation de l'autophagie par la modulation de produits geniques renforcant l'autophagie |
WO2011119759A1 (fr) | 2010-03-23 | 2011-09-29 | Irm Llc | Composés (lipopeptides à base de cystéine) et compositions en tant qu'agonistes des tlr2 utilisés pour traiter des infections, inflammations, maladies respiratoires entre autres |
JP2013537892A (ja) | 2010-09-22 | 2013-10-07 | ザ ユニバーシティー オブ メルボルン | 新規な免疫賦活法 |
US10668092B2 (en) | 2010-09-24 | 2020-06-02 | The John Hopkins University | Compositions and methods for treatment of inflammatory disorders |
US9072760B2 (en) | 2010-09-24 | 2015-07-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | TLR4 inhibitors for the treatment of human infectious and inflammatory disorders |
WO2012045090A2 (fr) * | 2010-10-01 | 2012-04-05 | Ventirx Pharmaceuticals, Inc. | Utilisation thérapeutique d'un agoniste de tlr, et polythérapie |
WO2012088425A2 (fr) | 2010-12-22 | 2012-06-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Agents favorisant les jonctions communicantes utilisables en vue du traitement de l'entérocolite nécrosante et des affections intestinales inflammatoires non spécifiques |
WO2013036543A2 (fr) * | 2011-09-10 | 2013-03-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Imagerie moléculaire de cellules cancéreuses in vivo |
WO2014052453A1 (fr) | 2012-09-25 | 2014-04-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thérapie orale de l'entérocolite nécrosante |
US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
EP3094342A4 (fr) | 2014-01-15 | 2017-12-27 | Nikolai Khodarev | Thérapie anti-tumorale |
WO2016044839A2 (fr) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions et méthodes pour traiter des infections virales par le biais de l'immunité innée stimulée en combinaison avec des composés antiviraux |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
WO2019099967A1 (fr) * | 2017-11-17 | 2019-05-23 | The University Of North Carolina At Chapel Hill | Procédés et traitements utilisant des agonistes des récepteurs de type toll pour atténuer la perte de cellules myéloïdes hématopoïétiques, améliorer la récupération gastro-intestinale et réduire la croissance tumorale |
CA3142501A1 (fr) | 2019-06-26 | 2020-12-30 | Axelia Oncology Pty Ltd | Nouvelles molecules |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2000025780A1 (fr) * | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Composes derives d'un noyau amine inhibiteurs de l'enzyme impdh |
IL151345A0 (en) | 2000-02-23 | 2003-04-10 | Univ California | Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation |
WO2003094836A2 (fr) | 2001-10-12 | 2003-11-20 | University Of Iowa Research Foundation | Methodes et produits permettant d'ameliorer des reponses immunitaires a l'aide de compose d'imidazoquinoline |
HUP0105406A3 (en) * | 2001-12-21 | 2003-12-29 | Sanofi Aventis | Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates |
AU2003243409A1 (en) | 2002-06-05 | 2003-12-22 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids |
WO2004071459A2 (fr) | 2003-02-13 | 2004-08-26 | 3M Innovative Properties Company | Procedes et compositions associes a des composes modificateurs de reponse immunitaire et recepteur 8 de type toll |
JP2006519020A (ja) | 2003-02-27 | 2006-08-24 | スリーエム イノベイティブ プロパティズ カンパニー | Tlr介在生物活性の選択的調節 |
US20050004144A1 (en) | 2003-04-14 | 2005-01-06 | Regents Of The University Of California | Combined use of IMPDH inhibitors with toll-like receptor agonists |
JP2007524615A (ja) | 2003-06-20 | 2007-08-30 | コーリー ファーマシューティカル ゲーエムベーハー | 低分子トール様レセプター(tlr)アンタゴニスト |
US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
EP1715884B1 (fr) | 2004-01-16 | 2012-03-07 | CBIO Limited | Modulation par la chaperonine 10 de la secretion de cytokine et de chemokine pouvant etre induite par le recepteur de type toll |
WO2005076824A2 (fr) | 2004-02-03 | 2005-08-25 | The Regents Of The University Of California | Methodes de traitement du syndrome du colon irritable |
-
2006
- 2006-02-21 AU AU2006216822A patent/AU2006216822A1/en not_active Abandoned
- 2006-02-21 WO PCT/US2006/006095 patent/WO2006091591A1/fr active Application Filing
- 2006-02-21 CA CA002598831A patent/CA2598831A1/fr not_active Abandoned
- 2006-02-21 EP EP06735661A patent/EP1858326A4/fr not_active Withdrawn
- 2006-02-21 US US11/359,945 patent/US7560436B2/en not_active Expired - Fee Related
- 2006-02-21 JP JP2007556399A patent/JP2008531502A/ja not_active Withdrawn
-
2007
- 2007-08-20 IL IL185396A patent/IL185396A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL185396A0 (en) | 2008-02-09 |
AU2006216822A1 (en) | 2006-08-31 |
EP1858326A1 (fr) | 2007-11-28 |
US20070004654A1 (en) | 2007-01-04 |
EP1858326A4 (fr) | 2008-10-15 |
WO2006091591A1 (fr) | 2006-08-31 |
US7560436B2 (en) | 2009-07-14 |
JP2008531502A (ja) | 2008-08-14 |
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