CA2595939C - Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists - Google Patents
Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists Download PDFInfo
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- CA2595939C CA2595939C CA2595939A CA2595939A CA2595939C CA 2595939 C CA2595939 C CA 2595939C CA 2595939 A CA2595939 A CA 2595939A CA 2595939 A CA2595939 A CA 2595939A CA 2595939 C CA2595939 C CA 2595939C
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Landscapes
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| US74995205P | 2005-12-13 | 2005-12-13 | |
| US60/749,952 | 2005-12-13 | ||
| PCT/US2006/005328 WO2006088956A2 (en) | 2005-02-14 | 2006-02-14 | Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists |
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| CA002595877A Abandoned CA2595877A1 (en) | 2005-02-14 | 2006-02-14 | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
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| CA002595877A Abandoned CA2595877A1 (en) | 2005-02-14 | 2006-02-14 | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
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Cited By (1)
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| RU2707181C1 (ru) * | 2019-08-15 | 2019-11-25 | федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ прогнозирования степени тяжести течения пруриго методом определения уровня концентрации триптазы в крови |
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| EP2325316B8 (en) | 1999-06-02 | 2017-04-19 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, NR10 |
| ES2254224T3 (es) | 1999-09-27 | 2006-06-16 | Chugai Seiyaku Kabushiki Kaisha | Nueva proteina del receptor de hematopoyetina, nr12. |
| ATE536406T1 (de) | 2002-01-18 | 2011-12-15 | Zymogenetics Inc | Neuartiger zytokin-zcytor17-ligand |
| US10080779B2 (en) | 2004-12-15 | 2018-09-25 | Universite D'angers | Method for increasing the expression of anti-microbial peptides by keratinocytes comprising administering a composition comprising IL-17, TNF-alpha and OSM |
| JP2008528039A (ja) * | 2005-01-28 | 2008-07-31 | ザイモジェネティクス，インコーポレイティド | Ｉｌ−３１の均質調製物 |
| EP1858924A1 (en) | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| CA2595939C (en) * | 2005-02-14 | 2014-08-19 | Zymogenetics Inc. | Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| AU2007254715B2 (en) | 2005-05-06 | 2013-08-29 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using IL-31 antagonists |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| EP2301969B1 (en) | 2005-05-06 | 2015-12-23 | ZymoGenetics, Inc. | IL-31 monoclonal antibodies and methods of use |
| MY157796A (en) | 2006-06-08 | 2016-07-29 | Chugai Pharmaceutical Co Ltd | Preventive or remedy for inflammatory disease |
| PT2594586E (pt) * | 2006-09-01 | 2014-11-26 | Zymogenetics Inc | Anticorpos monoclonais de il-31 e métodos de utilização |
| AU2008204823A1 (en) | 2007-01-10 | 2008-07-17 | Zymogenetics, Inc | Methods of using IL-31 to treat airway hyper-responsiveness and asthma |
| CN101939025B (zh) * | 2007-12-05 | 2015-03-25 | 中外制药株式会社 | 搔痒症治疗药 |
| ES2660036T3 (es) | 2007-12-07 | 2018-03-20 | Zymogenetics, Inc. | Moléculas de anticuerpo humanizadas específicas para IL-31 |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| WO2014208645A1 (ja) * | 2013-06-28 | 2014-12-31 | 中外製薬株式会社 | そう痒を伴う疾患に罹患した患者のｉｌ－３１アンタゴニストによる治療に対する応答を予測する方法 |
| MA40824A (fr) * | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
| JP5954916B1 (ja) | 2015-04-14 | 2016-07-20 | 中外製薬株式会社 | Ｉｌ−３１アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び／又は治療用医薬組成物 |
| WO2016167263A1 (ja) * | 2015-04-14 | 2016-10-20 | 中外製薬株式会社 | Ｉｌ－３１アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び／又は治療用医薬組成物 |
| US10060273B2 (en) | 2015-04-15 | 2018-08-28 | United Technologies Corporation | System and method for manufacture of abrasive coating |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| EP3765069A1 (en) | 2018-03-16 | 2021-01-20 | Zoetis Services LLC | Peptide vaccines against interleukin-31 |
| CA3093539A1 (en) | 2018-03-16 | 2019-09-19 | Zoetis Services Llc | Interleukin-31 monoclonal antibodies for veterinary use |
| SG11202010034WA (en) * | 2018-04-25 | 2020-11-27 | Kiniksa Pharmaceuticals Ltd | TREATMENT OF SKIN DISEASES OR DISORDERS BY DELIVERY OF ANTI-OSMRß ANTIBODY |
| CN112190708B (zh) * | 2019-07-08 | 2023-09-05 | 上海交通大学医学院附属瑞金医院 | 趋化因子受体ccr6抑制剂在预防银屑病复发中的新应用 |
| WO2021100794A1 (ja) | 2019-11-20 | 2021-05-27 | 中外製薬株式会社 | 抗体含有製剤 |
| KR102392954B1 (ko) * | 2020-02-11 | 2022-05-02 | 연세대학교 산학협력단 | 아토피 피부염 동물 모델인 아바타마우스의 제조 방법 및 그의 용도 |
| EP4209227A4 (en) | 2020-09-01 | 2024-05-29 | Chugai Seiyaku Kabushiki Kaisha | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF PRURITUS IN DIALYSIS CONTAINING AN IL-31 ANTAGONIST AS ACTIVE INGREDIENT |
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| US5792850A (en) * | 1996-05-23 | 1998-08-11 | Zymogenetics, Inc. | Hematopoietic cytokine receptor |
| EP1426059A4 (en) | 2001-09-14 | 2007-01-17 | Ono Pharmaceutical Co | DRUGS FOR TREATING PRURIT |
| DK1576112T3 (da) * | 2002-01-18 | 2012-06-25 | Zymogenetics Inc | Cytokin-receptor zcytor17-multimerer |
| ATE536406T1 (de) | 2002-01-18 | 2011-12-15 | Zymogenetics Inc | Neuartiger zytokin-zcytor17-ligand |
| JP2004219390A (ja) * | 2002-02-22 | 2004-08-05 | Taisho Pharmaceut Co Ltd | アトピー性皮膚炎に対し鎮痒効果を有する薬物の評価方法 |
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| JP2004107209A (ja) * | 2002-09-13 | 2004-04-08 | Nippon Oruganon Kk | 掻痒治療薬 |
| JP4503942B2 (ja) * | 2003-06-11 | 2010-07-14 | 大正製薬株式会社 | 止痒剤 |
| WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
| JP2008528039A (ja) | 2005-01-28 | 2008-07-31 | ザイモジェネティクス，インコーポレイティド | Ｉｌ−３１の均質調製物 |
| EP1858924A1 (en) * | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| CA2595939C (en) | 2005-02-14 | 2014-08-19 | Zymogenetics Inc. | Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists |
| EP2301969B1 (en) * | 2005-05-06 | 2015-12-23 | ZymoGenetics, Inc. | IL-31 monoclonal antibodies and methods of use |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| AU2007254715B2 (en) * | 2005-05-06 | 2013-08-29 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using IL-31 antagonists |
| JP5018481B2 (ja) * | 2005-09-28 | 2012-09-05 | コニカミノルタアドバンストレイヤー株式会社 | 射出成形装置 |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| PT2594586E (pt) | 2006-09-01 | 2014-11-26 | Zymogenetics Inc | Anticorpos monoclonais de il-31 e métodos de utilização |
| AU2008204823A1 (en) | 2007-01-10 | 2008-07-17 | Zymogenetics, Inc | Methods of using IL-31 to treat airway hyper-responsiveness and asthma |
| ES2660036T3 (es) * | 2007-12-07 | 2018-03-20 | Zymogenetics, Inc. | Moléculas de anticuerpo humanizadas específicas para IL-31 |
-
2006
- 2006-02-14 CA CA2595939A patent/CA2595939C/en not_active Expired - Fee Related
- 2006-02-14 US US11/353,454 patent/US20060188500A1/en not_active Abandoned
- 2006-02-14 EP EP06735136A patent/EP1856150A2/en not_active Withdrawn
- 2006-02-14 AU AU2006214326A patent/AU2006214326B2/en not_active Ceased
- 2006-02-14 WO PCT/US2006/005328 patent/WO2006088956A2/en not_active Ceased
- 2006-02-14 MX MX2007009577A patent/MX2007009577A/es active IP Right Grant
- 2006-02-14 JP JP2007555369A patent/JP2008530137A/ja active Pending
- 2006-02-14 CA CA002595877A patent/CA2595877A1/en not_active Abandoned
- 2006-02-14 JP JP2007555370A patent/JP4927762B2/ja not_active Expired - Fee Related
- 2006-02-14 WO PCT/US2006/005327 patent/WO2006088955A2/en not_active Ceased
- 2006-02-14 AU AU2006214325A patent/AU2006214325B2/en not_active Ceased
- 2006-02-14 MX MX2007009471A patent/MX2007009471A/es not_active Application Discontinuation
- 2006-02-14 EP EP06735137.9A patent/EP1856539B1/en not_active Not-in-force
- 2006-02-14 US US11/353,427 patent/US20060188499A1/en not_active Abandoned
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2007
- 2007-07-19 IL IL184734A patent/IL184734A/en not_active IP Right Cessation
- 2007-07-23 IL IL184776A patent/IL184776A/en not_active IP Right Cessation
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2008
- 2008-09-26 US US12/239,107 patent/US7723048B2/en active Active
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2009
- 2009-07-02 US US12/497,383 patent/US20090280121A1/en not_active Abandoned
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2010
- 2010-03-19 US US12/727,912 patent/US8435745B2/en not_active Expired - Fee Related
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2011
- 2011-04-26 US US13/094,482 patent/US8388964B2/en not_active Expired - Fee Related
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2012
- 2012-04-15 IL IL219145A patent/IL219145A0/en unknown
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2013
- 2013-01-30 US US13/754,278 patent/US20130177563A1/en not_active Abandoned
- 2013-03-13 US US13/799,048 patent/US8926957B2/en active Active
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2015
- 2015-10-09 US US14/879,550 patent/US20160024201A1/en not_active Abandoned
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2016
- 2016-12-20 US US15/384,774 patent/US20170096484A1/en not_active Abandoned
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- 2018-10-19 US US16/164,883 patent/US20190040125A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2707181C1 (ru) * | 2019-08-15 | 2019-11-25 | федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ прогнозирования степени тяжести течения пруриго методом определения уровня концентрации триптазы в крови |
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