CA2594676A1 - Thienopyrimidine derivatives as phosphodiesterase 10 inhibitors - Google Patents

Thienopyrimidine derivatives as phosphodiesterase 10 inhibitors Download PDF

Info

Publication number
CA2594676A1
CA2594676A1 CA002594676A CA2594676A CA2594676A1 CA 2594676 A1 CA2594676 A1 CA 2594676A1 CA 002594676 A CA002594676 A CA 002594676A CA 2594676 A CA2594676 A CA 2594676A CA 2594676 A1 CA2594676 A1 CA 2594676A1
Authority
CA
Canada
Prior art keywords
alkyl
chosen
substituted
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002594676A
Other languages
English (en)
French (fr)
Inventor
Ruiping Liu
Mark Phillip Arrington
Allen Hopper
Ashok Tehim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memory Pharmaceuticals Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2594676A1 publication Critical patent/CA2594676A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA002594676A 2004-12-23 2005-12-27 Thienopyrimidine derivatives as phosphodiesterase 10 inhibitors Abandoned CA2594676A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63817904P 2004-12-23 2004-12-23
US60/638,179 2004-12-23
PCT/US2005/047439 WO2006071988A1 (en) 2004-12-23 2005-12-27 Thienopyrimidine derivatives as phosphodiesterase 10 inhibitors

Publications (1)

Publication Number Publication Date
CA2594676A1 true CA2594676A1 (en) 2006-07-06

Family

ID=36128394

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002594676A Abandoned CA2594676A1 (en) 2004-12-23 2005-12-27 Thienopyrimidine derivatives as phosphodiesterase 10 inhibitors

Country Status (7)

Country Link
US (2) US7576080B2 (enExample)
EP (1) EP1831229A1 (enExample)
JP (1) JP2008525500A (enExample)
AU (1) AU2005321903A1 (enExample)
CA (1) CA2594676A1 (enExample)
MX (1) MX2007007387A (enExample)
WO (1) WO2006071988A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2923734B1 (en) 2009-03-13 2018-01-10 Katholieke Universiteit Leuven, K.U. Leuven R&D Purine analogues and their use as immunosuppressive agents
CA2768924A1 (en) * 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
PH12012501643A1 (en) * 2010-02-26 2017-07-19 Mitsubishi Tanabe Pharma Corp Pyrazolopyrimidine compounds and their use as pde 10 inhibitors
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
WO2012044562A2 (en) * 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. Pyrazolopyrimidine pde10 inhibitors
WO2012112946A1 (en) 2011-02-18 2012-08-23 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
HK1201066A1 (en) 2012-06-20 2015-08-21 霍夫曼-拉罗奇有限公司 Pyranopyridone inhibitors of tankyrase
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
CA2910751C (en) 2013-05-09 2021-02-23 Mitrassist Medical Ltd. Heart valve assistive prosthesis
US10039764B2 (en) 2013-07-12 2018-08-07 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR122020001830B1 (pt) * 2015-05-18 2023-02-28 Shenyang Sinochem Agrochemicals R&D Co., LTD Compostos pirazol substituídos contendo pirimidinila, preparação e aplicação dos mesmos
CN108358966B (zh) * 2018-03-05 2020-04-28 南京工业大学 一种靶向-增强线粒体功能药物Mito-VB3及其制备方法和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1570494A (en) 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
PH23495A (en) 1985-03-14 1989-08-16 Sankyo Co Phenoxyalkylaminopyrimidine derivatives and the composition and method of use thereof
JPH02105081A (ja) 1988-10-14 1990-04-17 Mitsubishi Electric Corp アナログ試験装置
AU651337B2 (en) 1990-03-30 1994-07-21 Dowelanco Thienopyrimidine derivatives
US5227387A (en) 1991-09-03 1993-07-13 Dowelanco Quinoline nematicidal method
GB9517986D0 (en) 1995-09-04 1995-11-08 Sandoz Ltd Organic compounds
AR004010A1 (es) * 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
WO1997017843A1 (fr) 1995-11-16 1997-05-22 Dnavec Research Inc. Procede pour realiser des animaux transgeniques
SK6652000A3 (en) 1997-11-11 2002-05-09 Pfizer Prod Inc Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
ES2219033T3 (es) 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
US20030162795A1 (en) 1998-10-22 2003-08-28 Pfizer Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
AU4157500A (en) 1999-03-26 2000-10-16 Astrazeneca Ab Novel compounds
WO2001021206A1 (en) 1999-09-17 2001-03-29 Suntory Limited PREVENTIVES OR REMEDIES FOR MYOCARDITIS, DILATED CARDIOMYOPATHY AND CARDIAC INSUFFICIENCY CONTAINING NF-λB INHIBITORS AS THE ACTIVE INGREDIENT
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
DE10130167A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Imidazotriazine
EP1465900B1 (en) 2002-01-10 2008-05-14 Bayer HealthCare AG Rho-kinase inhibitors
US6945478B2 (en) * 2002-03-15 2005-09-20 Siemens Vdo Automotive Corporation Fuel injector having an orifice plate with offset coining angled orifices
US20040138238A1 (en) 2002-08-08 2004-07-15 Dhanoa Dale S. Substituted aminopyrimidine compounds as neurokinin antagonists
US7612078B2 (en) 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US20050222175A1 (en) 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
WO2004092123A2 (en) 2003-04-10 2004-10-28 Microbia, Inc. Inhibitors of fungal invasion
GB0315950D0 (en) * 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
CN1823071B (zh) 2003-06-11 2012-12-19 润生有限公司 用作钾通道抑制剂的噻吩并嘧啶衍生物
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions

Also Published As

Publication number Publication date
US7576080B2 (en) 2009-08-18
MX2007007387A (es) 2007-08-03
EP1831229A1 (en) 2007-09-12
JP2008525500A (ja) 2008-07-17
WO2006071988A1 (en) 2006-07-06
US20070259896A1 (en) 2007-11-08
US20100010017A1 (en) 2010-01-14
AU2005321903A1 (en) 2006-07-06

Similar Documents

Publication Publication Date Title
US20100010017A1 (en) Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
US20070093515A1 (en) Phosphodiesterase 10 inhibitors
CN110177793B (zh) 杂芳基并吡唑类衍生物、其制备方法及其在医药上的应用
AU2011351375B2 (en) Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
US20060160814A1 (en) Phosphodiesterase 10 inhibitors
US11261164B2 (en) Small molecule agonists of neurotensin receptor 1
RS62874B1 (sr) Inhibitori lizin specifične demetilaze-1
AU2021269397B2 (en) Compounds and compositions for the treatment of cancer
CA2753236A1 (en) Pyrrolopyrimidines used as kinase inhibitors
RS63074B1 (sr) Inhibitori lizin specifične demetilaze-1
WO2023224998A1 (en) Inhibitors of parg
AU2003295656A2 (en) Pyridine N-oxide compounds as phosphodiesterase 4 inhibitors
KR20080108540A (ko) 아미노메틸피리딘 유도체, 그의 제조 방법 및 그의 치료학적 용도
JP2012505264A (ja) チエノ［２，３−Ｄ］ピリミジンのメチレンアミン、並びに、アデノシンＡ２ａ受容体拮抗薬としてのそれらの使用
JP2007509123A (ja) キナーゼ阻害剤としてのチエノ−ピリジノン誘導体
JP2026501225A (ja) 環状ｇｍｐ－ａｍｐ合成酵素の阻害剤としてのチアジアゾール誘導体及びその使用
CA2740408A1 (en) Amides of thieno[2,3-d]pyrimidine and their use as adenosine a2a receptor antagonists
US20100144714A1 (en) Derivatives of imidazo pyrimido and diazepine pyrimidine-dione, and use thereof as a drug
CA2740410A1 (en) Phenyl and heteroaryl substituted thieno[2,3-d] pyrimidines and their use as adenosine a2a receptor antagonists
EP4514806A1 (en) Compositions useful for modulating splicing

Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20111228