CA2592449C - Recombinant microorganisms for increased production of organic acids - Google Patents

Recombinant microorganisms for increased production of organic acids Download PDF

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Publication number
CA2592449C
CA2592449C CA2592449A CA2592449A CA2592449C CA 2592449 C CA2592449 C CA 2592449C CA 2592449 A CA2592449 A CA 2592449A CA 2592449 A CA2592449 A CA 2592449A CA 2592449 C CA2592449 C CA 2592449C
Authority
CA
Canada
Prior art keywords
microorganism
zwf
polynucleotide
succinic acid
recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2592449A
Other languages
English (en)
French (fr)
Other versions
CA2592449A1 (en
Inventor
Jian Yi
Susanne Kleff
Michael V. Guettler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Michigan Biotechnology Institute
Original Assignee
Michigan Biotechnology Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Biotechnology Institute filed Critical Michigan Biotechnology Institute
Publication of CA2592449A1 publication Critical patent/CA2592449A1/en
Application granted granted Critical
Publication of CA2592449C publication Critical patent/CA2592449C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2592449A 2004-12-22 2005-12-16 Recombinant microorganisms for increased production of organic acids Expired - Lifetime CA2592449C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63944304P 2004-12-22 2004-12-22
US60/639,443 2004-12-22
US64714105P 2005-01-26 2005-01-26
US60/647,141 2005-01-26
PCT/US2005/045714 WO2006083410A2 (en) 2004-12-22 2005-12-16 Recombinant microorganisms for increased production of organic acids

Publications (2)

Publication Number Publication Date
CA2592449A1 CA2592449A1 (en) 2006-08-10
CA2592449C true CA2592449C (en) 2015-11-24

Family

ID=36777690

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2592449A Expired - Lifetime CA2592449C (en) 2004-12-22 2005-12-16 Recombinant microorganisms for increased production of organic acids

Country Status (10)

Country Link
US (2) US8119377B2 (https=)
EP (2) EP2460872A1 (https=)
JP (2) JP5634659B2 (https=)
KR (1) KR101357015B1 (https=)
CN (1) CN101128577B (https=)
BR (1) BRPI0519174A2 (https=)
CA (1) CA2592449C (https=)
ES (1) ES2541538T3 (https=)
MX (1) MX2007007834A (https=)
WO (1) WO2006083410A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008153676A2 (en) * 2007-05-21 2008-12-18 The Regents Of The University Of California Pentose phosphate pathway and fermentation enzyme-encoding nucleotide sequences with refined translational kinetics and methods of making same
WO2009024294A1 (en) * 2007-08-17 2009-02-26 Basf Se Microbial succinic acid producer mannheimia succini producens ddl
EP2220234B1 (en) 2007-11-20 2012-06-27 DSM IP Assets B.V. Dicarboxylic acid production in a recombinant yeast
EP2687602A1 (en) 2007-11-20 2014-01-22 DSM IP Assets B.V. Succinic acid production in a eukaryotic cell
EP2252685A2 (en) * 2008-03-13 2010-11-24 DSM IP Assets B.V. Selection of organisms capable of fermenting mixed substrates
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8431372B2 (en) * 2009-06-19 2013-04-30 Mbi International Fermentation method using a magnesium compound containing oxygen
SG11201401811WA (en) † 2011-08-30 2014-09-26 Amc Amsterdam Method for preventing and/or treating insulin resistance
US20150017698A1 (en) * 2012-03-02 2015-01-15 Codexis, Inc. a corporation Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate
US11929532B2 (en) 2012-09-09 2024-03-12 Biocheminsights, Inc. Electrochemical bioreactor module and methods of using the same
CA2883407A1 (en) * 2012-10-02 2014-04-10 The Michigan Biotechnology Institute Recombinant microorganisms for producing organic acids
US20140093926A1 (en) 2012-10-02 2014-04-03 Board Of Trustees Of Michigan State University Integrated systems and methods for organic acid production
CN104178443B (zh) * 2013-05-24 2017-04-12 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
CN104178442B (zh) 2013-05-24 2017-10-31 中国科学院天津工业生物技术研究所 含有突变的lpdA基因的大肠杆菌及其应用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3652301A1 (en) * 2017-07-11 2020-05-20 Adisseo France S.A.S. Enhanced metabolite-producing yeast
KR102912596B1 (ko) 2020-07-24 2026-01-13 삼성전자주식회사 프로모터 영역을 포함하는 분리된 폴리뉴클레오티드, 그를 포함하는 숙주 세포 및 상기 숙주 세포를 이용하여 목적 유전자를 발현시키는 방법
CN113106129A (zh) * 2020-09-29 2021-07-13 安徽华恒生物科技股份有限公司 一种高转化率的d泛解酸内酯制备方法
CN116333900A (zh) * 2021-12-15 2023-06-27 中国科学院大连化学物理研究所 一种提高酵母菌株nadph和fadh2供应的方法、工程菌及其应用
WO2025229145A1 (en) 2024-05-02 2025-11-06 Stichting Amsterdam UMC Desulfovibrio piger species for prevention or treatment of hepatic steatosis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
JP3967812B2 (ja) * 1998-01-16 2007-08-29 三菱化学株式会社 ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
JPH11196887A (ja) * 1998-01-16 1999-07-27 Mitsubishi Chemical Corp ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
EP1208205B1 (en) * 1999-07-23 2006-09-27 Archer-Daniels-Midland Company Methods for producing l-amino acids by increasing cellular nadph
JP2002291477A (ja) * 2001-03-30 2002-10-08 Mitsubishi Chemicals Corp フマラーゼをコードするｄｎａ及びその利用
AU2002328223A1 (en) * 2001-09-21 2003-04-01 Affinium Pharmaceuticals, Inc. Purified polypeptides involved in co-factor metabolism
JP4333088B2 (ja) * 2002-06-26 2009-09-16 味の素株式会社 グルコノバクター属細菌の新規遺伝子及び目的物質の製造法
KR101035043B1 (ko) * 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
US7163812B2 (en) * 2003-08-06 2007-01-16 Board Of Trustees Of Michigan State University Actinobacillus succinogenes shuttle vector and methods of use
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005042736A1 (en) 2003-10-30 2005-05-12 Michaela Slanicka Krieger Cell culture supplement for the in vitro cultivation of cells and a method for culturing cells
JP2005217918A (ja) 2004-01-30 2005-08-11 Toshiba Corp 受信装置

Also Published As

Publication number Publication date
WO2006083410A3 (en) 2006-11-23
JP2012034702A (ja) 2012-02-23
US20120164703A1 (en) 2012-06-28
KR20070108155A (ko) 2007-11-08
US8119377B2 (en) 2012-02-21
JP2008525026A (ja) 2008-07-17
EP1838837A2 (en) 2007-10-03
EP1838837B1 (en) 2015-04-15
JP5655217B2 (ja) 2015-01-21
EP2460872A1 (en) 2012-06-06
KR101357015B1 (ko) 2014-02-03
EP1838837A4 (en) 2009-01-14
CA2592449A1 (en) 2006-08-10
JP5634659B2 (ja) 2014-12-03
BRPI0519174A2 (pt) 2008-12-30
MX2007007834A (es) 2007-09-04
US20080305533A1 (en) 2008-12-11
US8431373B2 (en) 2013-04-30
CN101128577A (zh) 2008-02-20
ES2541538T3 (es) 2015-07-21
CN101128577B (zh) 2013-06-19
WO2006083410A2 (en) 2006-08-10

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