CA2589328A1 - Multicyclic bis-amide mmp inhibitors - Google Patents

Multicyclic bis-amide mmp inhibitors Download PDF

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Publication number
CA2589328A1
CA2589328A1 CA002589328A CA2589328A CA2589328A1 CA 2589328 A1 CA2589328 A1 CA 2589328A1 CA 002589328 A CA002589328 A CA 002589328A CA 2589328 A CA2589328 A CA 2589328A CA 2589328 A1 CA2589328 A1 CA 2589328A1
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CA
Canada
Prior art keywords
alkyl
group
optionally substituted
nr10r11
cycloalkyl
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Abandoned
Application number
CA002589328A
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English (en)
French (fr)
Inventor
Timothy Powers
Christoph Steeneck
Ralf Biesinger
Harald Bluhm
Hongbo Deng
Rory Dodd
Brian M. Gallagher, Jr.
Christian Gege
Matthias Hochgurtel
Andrew Kiely
Frank Richter
Mathias Schneider
Irving Sucholeiki
Joshua Van Veldhuizen
Xinyuan Wu
Arthur G. Taveras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alantos Pharmaceuticals Holding Inc
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Individual
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Filing date
Publication date
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Publication of CA2589328A1 publication Critical patent/CA2589328A1/en
Abandoned legal-status Critical Current

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
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  • Psychology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
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CA002589328A 2004-12-31 2005-12-31 Multicyclic bis-amide mmp inhibitors Abandoned CA2589328A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64079504P 2004-12-31 2004-12-31
US60/640,795 2004-12-31
US70626705P 2005-08-08 2005-08-08
US60/706,267 2005-08-08
PCT/US2005/047421 WO2006083454A1 (en) 2004-12-31 2005-12-31 Multicyclic bis-amide mmp inhibitors

Publications (1)

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CA2589328A1 true CA2589328A1 (en) 2006-08-10

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CA002589328A Abandoned CA2589328A1 (en) 2004-12-31 2005-12-31 Multicyclic bis-amide mmp inhibitors

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Country Link
US (1) US20060173183A1 (https=)
EP (1) EP1843820A1 (https=)
JP (1) JP2008526761A (https=)
AU (1) AU2005326659A1 (https=)
CA (1) CA2589328A1 (https=)
MX (1) MX2007007895A (https=)
WO (1) WO2006083454A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608890C (en) * 2005-05-20 2011-08-02 Alantos-Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20070155737A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
AU2006332694A1 (en) * 2005-12-30 2007-07-12 Alantos Pharmaceuticals, Holding, Inc. Substituted bis-amide metalloprotease inhibitors
CA2658362A1 (en) * 2006-06-29 2008-01-03 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors
ATE528306T1 (de) * 2006-11-02 2011-10-15 Piramal Life Sciences Ltd Benzoxazepin-verbindungen, ihre herstellung und verwendung
AU2007321923A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic matrix metalloprotease inhibitors
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