CA2587642C - Substituted heterocycles and methods of use - Google Patents
Substituted heterocycles and methods of use Download PDFInfo
- Publication number
- CA2587642C CA2587642C CA2587642A CA2587642A CA2587642C CA 2587642 C CA2587642 C CA 2587642C CA 2587642 A CA2587642 A CA 2587642A CA 2587642 A CA2587642 A CA 2587642A CA 2587642 C CA2587642 C CA 2587642C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- phenyl
- methoxy
- pharmaceutically acceptable
- oxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63227104P | 2004-11-30 | 2004-11-30 | |
| US60/632,271 | 2004-11-30 | ||
| PCT/US2005/042935 WO2006060318A2 (en) | 2004-11-30 | 2005-11-29 | Quinolines and quinazoline analogs and their use as medicaments for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2587642A1 CA2587642A1 (en) | 2006-06-08 |
| CA2587642C true CA2587642C (en) | 2013-04-09 |
Family
ID=36215740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2587642A Expired - Fee Related CA2587642C (en) | 2004-11-30 | 2005-11-29 | Substituted heterocycles and methods of use |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7652009B2 (enExample) |
| EP (1) | EP1827434B1 (enExample) |
| JP (1) | JP2008521900A (enExample) |
| AU (1) | AU2005312048B2 (enExample) |
| CA (1) | CA2587642C (enExample) |
| ES (1) | ES2450566T3 (enExample) |
| MX (1) | MX2007006230A (enExample) |
| WO (1) | WO2006060318A2 (enExample) |
Families Citing this family (64)
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| TWI377198B (en) * | 2005-08-24 | 2012-11-21 | Eisai R&D Man Co Ltd | Novel pyridine derivatives and pyrimidine derivatives (3) |
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| CA2655128A1 (en) * | 2006-06-08 | 2007-12-21 | Array Biopharma Inc. | Quinoline compounds and methods of use |
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| US7790885B2 (en) * | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
| EP2125781A2 (en) | 2006-12-20 | 2009-12-02 | Amgen Inc. | Substituted heterocycles and methods of use |
| CN101686686A (zh) * | 2007-02-20 | 2010-03-31 | 梅里奥尔医药I公司 | 鉴别Lyn激酶激活剂的方法 |
| EP2132207A2 (en) * | 2007-03-23 | 2009-12-16 | Amgen Inc. | Heterocyclic compounds and their uses |
| JP5550546B2 (ja) * | 2007-04-13 | 2014-07-16 | ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド | 経口セファロタキシン剤形 |
| JP2010534668A (ja) * | 2007-07-23 | 2010-11-11 | メリオール・ディスカヴァリー・インコーポレイテッド | Ｉｒｓ−１及びａｋｔを活性化する方法 |
| JP2009132660A (ja) * | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
| JP2009203226A (ja) * | 2008-01-31 | 2009-09-10 | Eisai R & D Management Co Ltd | ピリジン誘導体およびピリミジン誘導体を含有するレセプターチロシンキナーゼ阻害剤 |
| US20100311972A1 (en) * | 2008-02-18 | 2010-12-09 | Mitsuo Nagai | Method for producing phenoxypyridine derivative |
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| KR20110133048A (ko) * | 2009-03-21 | 2011-12-09 | 닝 시 | 아미노 에스테르 유도체, 그의 염 및 이용 방법 |
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| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
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| TWI520962B (zh) | 2012-06-29 | 2016-02-11 | As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives | |
| CN104507930B (zh) * | 2012-06-29 | 2017-10-10 | 贝达药业股份有限公司 | 作为c‑Met酪氨酸激酶抑制剂的新型稠合吡啶衍生物 |
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| RU2015115397A (ru) | 2012-12-21 | 2017-01-25 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Аморфная форма производного хинолина и способ его получения |
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-
2005
- 2005-11-29 JP JP2007544417A patent/JP2008521900A/ja not_active Withdrawn
- 2005-11-29 EP EP05848812.3A patent/EP1827434B1/en not_active Expired - Lifetime
- 2005-11-29 MX MX2007006230A patent/MX2007006230A/es not_active Application Discontinuation
- 2005-11-29 CA CA2587642A patent/CA2587642C/en not_active Expired - Fee Related
- 2005-11-29 AU AU2005312048A patent/AU2005312048B2/en not_active Ceased
- 2005-11-29 WO PCT/US2005/042935 patent/WO2006060318A2/en not_active Ceased
- 2005-11-29 US US11/289,659 patent/US7652009B2/en active Active
- 2005-11-29 ES ES05848812.3T patent/ES2450566T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2450566T3 (es) | 2014-03-25 |
| EP1827434A2 (en) | 2007-09-05 |
| WO2006060318A2 (en) | 2006-06-08 |
| EP1827434B1 (en) | 2014-01-15 |
| WO2006060318A3 (en) | 2006-07-20 |
| JP2008521900A (ja) | 2008-06-26 |
| US20060252777A1 (en) | 2006-11-09 |
| CA2587642A1 (en) | 2006-06-08 |
| MX2007006230A (es) | 2007-07-25 |
| AU2005312048A1 (en) | 2006-06-08 |
| US7652009B2 (en) | 2010-01-26 |
| AU2005312048B2 (en) | 2012-08-02 |
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| MKLA | Lapsed |
Effective date: 20151130 |