CA2585647A1 - Dose forms - Google Patents
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- CA2585647A1 CA2585647A1 CA002585647A CA2585647A CA2585647A1 CA 2585647 A1 CA2585647 A1 CA 2585647A1 CA 002585647 A CA002585647 A CA 002585647A CA 2585647 A CA2585647 A CA 2585647A CA 2585647 A1 CA2585647 A1 CA 2585647A1
- Authority
- CA
- Canada
- Prior art keywords
- amount
- patient
- administering
- hcv
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
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- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US62354204P | 2004-10-29 | 2004-10-29 | |
| US60/623,542 | 2004-10-29 | ||
| US67940205P | 2005-05-09 | 2005-05-09 | |
| US60/679,402 | 2005-05-09 | ||
| US68209105P | 2005-05-17 | 2005-05-17 | |
| US60/682,091 | 2005-05-17 | ||
| US72274605P | 2005-09-30 | 2005-09-30 | |
| US60/722,746 | 2005-09-30 | ||
| PCT/US2005/039240 WO2006050250A2 (en) | 2004-10-29 | 2005-10-31 | Dose forms comprising vx-950 and their dosage regimen |
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| CA2585647A1 true CA2585647A1 (en) | 2006-05-11 |
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| CA002585647A Abandoned CA2585647A1 (en) | 2004-10-29 | 2005-10-31 | Dose forms |
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| EP (2) | EP1819336A2 (enExample) |
| JP (2) | JP2008518943A (enExample) |
| KR (2) | KR20070085547A (enExample) |
| CN (1) | CN102988365A (enExample) |
| AU (1) | AU2005302361B2 (enExample) |
| CA (1) | CA2585647A1 (enExample) |
| IL (1) | IL182847A0 (enExample) |
| MX (1) | MX2007005179A (enExample) |
| MY (1) | MY141025A (enExample) |
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| RU (1) | RU2393863C2 (enExample) |
| TW (2) | TWI437990B (enExample) |
| WO (1) | WO2006050250A2 (enExample) |
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| US20120201883A1 (en) * | 2004-05-21 | 2012-08-09 | Accu-Break Technologies, Inc | Antiviral compositons |
| WO2005123076A2 (en) * | 2004-06-08 | 2005-12-29 | Vertex Pharmaceuticals, Inc. | Pharmaceutical compositions |
| US8119602B2 (en) * | 2005-06-02 | 2012-02-21 | Schering Corporation | Administration of HCV protease inhibitors in combination with food to improve bioavailability |
| US20060287248A1 (en) * | 2005-06-02 | 2006-12-21 | Schering Corporation | Asymmetric dosing methods |
| US7772178B2 (en) * | 2005-06-02 | 2010-08-10 | Schering Corporation | Pharmaceutical formulations and methods of treatment using the same |
| ES2401661T3 (es) * | 2005-08-02 | 2013-04-23 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| EP1991229A2 (en) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| JP2009531315A (ja) | 2006-03-16 | 2009-09-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | 重水素化ｃ型肝炎プロテアーゼインヒビター |
| EP2518079A3 (en) | 2006-04-11 | 2012-12-12 | Novartis AG | HCV/HIV inhibitors and their uses |
| CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| US8575208B2 (en) * | 2007-02-27 | 2013-11-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| EA200970806A1 (ru) * | 2007-02-27 | 2010-08-30 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
| EP2157974A1 (en) * | 2007-05-21 | 2010-03-03 | Vertex Pharmceuticals Incorporated | Dose forms comprising vx- 950 and their dosage regimen |
| EP2436682A1 (en) * | 2007-08-30 | 2012-04-04 | Vertex Pharmceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| KR101396696B1 (ko) * | 2007-10-10 | 2014-05-16 | 노파르티스 아게 | 스피로피롤리딘, 및 ｈｃｖ 및 ｈｉｖ 감염에 대한 그의 용도 |
| EP2214682A2 (en) * | 2007-11-05 | 2010-08-11 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies comprising vx-950, peg-ifn and ribavirin |
| JP5750266B2 (ja) * | 2008-02-28 | 2015-07-15 | アッヴィ・インコーポレイテッド | 錠剤およびその調製 |
| EP2280709A1 (en) * | 2008-04-23 | 2011-02-09 | Vertex Pharmaceuticals Incorporated | Treatment of hepatitis c virus infections with telaprevir (vx-950) in patients non-responsive to treatment with pegylated interfer0n-alpha-2a/2b and ribavirin |
| US20100069821A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable medicament release-sites final dosage form |
| US20100068152A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable particle or polymeric based final dosage form |
| US20100068235A1 (en) * | 2008-09-16 | 2010-03-18 | Searete LLC, a limited liability corporation of Deleware | Individualizable dosage form |
| US20100068153A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo activatable final dosage form |
| US20100069887A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Multiple chamber ex vivo adjustable-release final dosage form |
| US20100068233A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Modifiable dosage form |
| US20100068266A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo-modifiable multiple-release state final dosage form |
| US20100068275A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Personalizable dosage form |
| US20100068254A1 (en) * | 2008-09-16 | 2010-03-18 | Mahalaxmi Gita Bangera | Modifying a medicament availability state of a final dosage form |
| KR20110074870A (ko) * | 2008-09-24 | 2011-07-04 | 버텍스 파마슈티칼스 인코포레이티드 | 간염을 치료하기 위한 ｐｅｇ-인터페론, 리바비린 및 ｖｘ-950을 포함하는 치료 요법 |
| EP2358439A1 (en) * | 2008-11-05 | 2011-08-24 | Vertex Pharmaceuticals Incorporated | Methods for treating hepatitis c virus infection |
| DE102008064038A1 (de) * | 2008-12-22 | 2010-07-01 | Ksb Aktiengesellschaft | Vorrichtung und Verfahren zur Detektion von Belägen |
| EP2396028A2 (en) * | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| AU2011210795A1 (en) | 2010-01-29 | 2012-08-02 | Vertex Pharmaceuticals Incorporated | Therapies for treating Hepatitis C virus infection |
| WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
| EP2593105A1 (en) | 2010-07-14 | 2013-05-22 | Vertex Pharmaceuticals Incorporated | Palatable pharmaceutical composition comprising vx-950 |
| CA2815416A1 (en) | 2010-10-21 | 2012-04-26 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
| WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
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| WO2014015217A1 (en) | 2012-07-19 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
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| DE69334250D1 (de) | 1992-12-29 | 2009-01-29 | Abbott Lab | Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern |
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| WO2005123076A2 (en) * | 2004-06-08 | 2005-12-29 | Vertex Pharmaceuticals, Inc. | Pharmaceutical compositions |
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2005
- 2005-10-28 MY MYPI20055106A patent/MY141025A/en unknown
- 2005-10-28 TW TW094137981A patent/TWI437990B/zh not_active IP Right Cessation
- 2005-10-28 TW TW103100886A patent/TW201424733A/zh unknown
- 2005-10-31 MX MX2007005179A patent/MX2007005179A/es unknown
- 2005-10-31 WO PCT/US2005/039240 patent/WO2006050250A2/en not_active Ceased
- 2005-10-31 JP JP2007539241A patent/JP2008518943A/ja active Pending
- 2005-10-31 US US11/264,746 patent/US8431615B2/en not_active Expired - Fee Related
- 2005-10-31 KR KR1020077012147A patent/KR20070085547A/ko not_active Ceased
- 2005-10-31 CN CN2012104136092A patent/CN102988365A/zh active Pending
- 2005-10-31 KR KR1020137009594A patent/KR20130063022A/ko not_active Ceased
- 2005-10-31 RU RU2007119725/14A patent/RU2393863C2/ru not_active IP Right Cessation
- 2005-10-31 AU AU2005302361A patent/AU2005302361B2/en not_active Ceased
- 2005-10-31 EP EP05815054A patent/EP1819336A2/en not_active Withdrawn
- 2005-10-31 EP EP11184992A patent/EP2500021A1/en not_active Withdrawn
- 2005-10-31 CA CA002585647A patent/CA2585647A1/en not_active Abandoned
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2007
- 2007-04-29 IL IL182847A patent/IL182847A0/en unknown
- 2007-05-29 NO NO20072733A patent/NO20072733L/no not_active Application Discontinuation
-
2013
- 2013-01-09 JP JP2013001638A patent/JP2013060474A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008518943A (ja) | 2008-06-05 |
| TW201424733A (zh) | 2014-07-01 |
| US20060105978A1 (en) | 2006-05-18 |
| IL182847A0 (en) | 2007-09-20 |
| KR20130063022A (ko) | 2013-06-13 |
| CN102988365A (zh) | 2013-03-27 |
| US8431615B2 (en) | 2013-04-30 |
| JP2013060474A (ja) | 2013-04-04 |
| MY141025A (en) | 2010-02-25 |
| TW200630093A (en) | 2006-09-01 |
| RU2007119725A (ru) | 2008-12-20 |
| WO2006050250A3 (en) | 2006-07-27 |
| EP2500021A1 (en) | 2012-09-19 |
| RU2393863C2 (ru) | 2010-07-10 |
| AU2005302361B2 (en) | 2011-11-17 |
| NO20072733L (no) | 2007-05-29 |
| EP1819336A2 (en) | 2007-08-22 |
| MX2007005179A (es) | 2008-03-06 |
| TWI437990B (zh) | 2014-05-21 |
| WO2006050250A2 (en) | 2006-05-11 |
| AU2005302361A1 (en) | 2006-05-11 |
| KR20070085547A (ko) | 2007-08-27 |
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| EEER | Examination request | ||
| FZDE | Discontinued |
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