CA2581807A1 - 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-7-ethynyl-3-quinolinecarbonitriles for the treatment of ischemic injury - Google Patents
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-7-ethynyl-3-quinolinecarbonitriles for the treatment of ischemic injury Download PDFInfo
- Publication number
- CA2581807A1 CA2581807A1 CA002581807A CA2581807A CA2581807A1 CA 2581807 A1 CA2581807 A1 CA 2581807A1 CA 002581807 A CA002581807 A CA 002581807A CA 2581807 A CA2581807 A CA 2581807A CA 2581807 A1 CA2581807 A1 CA 2581807A1
- Authority
- CA
- Canada
- Prior art keywords
- dichloro
- methoxyphenyl
- ischemic event
- compound
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 2,4-dichloro-5-methoxyphenyl Chemical group 0.000 title description 15
- 238000011282 treatment Methods 0.000 title description 14
- 208000037906 ischaemic injury Diseases 0.000 title description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 58
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- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 3
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62128004P | 2004-10-22 | 2004-10-22 | |
| US60/621,280 | 2004-10-22 | ||
| PCT/US2005/037839 WO2006047262A1 (en) | 2004-10-22 | 2005-10-21 | 4 [(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-7-ethynyl-3-quinolinecarbonitriles for the treatment of ischemic injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2581807A1 true CA2581807A1 (en) | 2006-05-04 |
Family
ID=35784691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002581807A Abandoned CA2581807A1 (en) | 2004-10-22 | 2005-10-21 | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-7-ethynyl-3-quinolinecarbonitriles for the treatment of ischemic injury |
Country Status (23)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200829555A (en) * | 2006-11-10 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| CN102952037A (zh) * | 2012-11-18 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种2-氰基-n-(2,4-二氯-5-甲氧苯基)乙酰胺的合成方法 |
| WO2014086284A1 (zh) * | 2012-12-04 | 2014-06-12 | 上海医药集团股份有限公司 | 一类氘代3-氰基喹啉类化合物、其药用组合物、制备方法及其用途 |
| CN114436851B (zh) * | 2022-01-17 | 2023-08-22 | 常州大学 | 一种n,n-二甲基苄胺及其衍生物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| US6521618B2 (en) * | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| TWI275390B (en) * | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| TW200423938A (en) * | 2003-02-21 | 2004-11-16 | Wyeth Corp | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury |
-
2005
- 2005-10-21 SI SI200530255T patent/SI1802581T1/sl unknown
- 2005-10-21 KR KR1020077011472A patent/KR20070085413A/ko not_active Withdrawn
- 2005-10-21 RU RU2007111704/04A patent/RU2007111704A/ru not_active Application Discontinuation
- 2005-10-21 US US11/255,556 patent/US20060116375A1/en not_active Abandoned
- 2005-10-21 EP EP05820982A patent/EP1802581B1/en not_active Expired - Lifetime
- 2005-10-21 AU AU2005299822A patent/AU2005299822A1/en not_active Abandoned
- 2005-10-21 DK DK05820982T patent/DK1802581T3/da active
- 2005-10-21 PT PT05820982T patent/PT1802581E/pt unknown
- 2005-10-21 JP JP2007538054A patent/JP2008517924A/ja not_active Withdrawn
- 2005-10-21 DE DE602005005843T patent/DE602005005843T2/de not_active Expired - Lifetime
- 2005-10-21 AT AT05820982T patent/ATE391122T1/de not_active IP Right Cessation
- 2005-10-21 CN CNA2005800360383A patent/CN101044117A/zh active Pending
- 2005-10-21 ES ES05820982T patent/ES2303287T3/es not_active Expired - Lifetime
- 2005-10-21 PL PL05820982T patent/PL1802581T3/pl unknown
- 2005-10-21 WO PCT/US2005/037839 patent/WO2006047262A1/en not_active Ceased
- 2005-10-21 BR BRPI0516995-0A patent/BRPI0516995A/pt not_active IP Right Cessation
- 2005-10-21 MX MX2007004833A patent/MX2007004833A/es active IP Right Grant
- 2005-10-21 CA CA002581807A patent/CA2581807A1/en not_active Abandoned
-
2007
- 2007-03-30 NO NO20071708A patent/NO20071708L/no not_active Application Discontinuation
- 2007-04-11 EC EC2007007385A patent/ECSP077385A/es unknown
- 2007-04-12 IL IL182547A patent/IL182547A0/en unknown
- 2007-04-20 ZA ZA200703275A patent/ZA200703275B/xx unknown
- 2007-04-20 CR CR9072A patent/CR9072A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070085413A (ko) | 2007-08-27 |
| AU2005299822A1 (en) | 2006-05-04 |
| CR9072A (es) | 2007-09-07 |
| MX2007004833A (es) | 2007-05-16 |
| PT1802581E (pt) | 2008-06-03 |
| EP1802581B1 (en) | 2008-04-02 |
| WO2006047262A1 (en) | 2006-05-04 |
| NO20071708L (no) | 2007-07-13 |
| ATE391122T1 (de) | 2008-04-15 |
| DE602005005843T2 (de) | 2009-05-14 |
| CN101044117A (zh) | 2007-09-26 |
| EP1802581A1 (en) | 2007-07-04 |
| DE602005005843D1 (de) | 2008-05-15 |
| ECSP077385A (es) | 2007-05-30 |
| PL1802581T3 (pl) | 2008-09-30 |
| ES2303287T3 (es) | 2008-08-01 |
| JP2008517924A (ja) | 2008-05-29 |
| US20060116375A1 (en) | 2006-06-01 |
| IL182547A0 (en) | 2007-09-20 |
| SI1802581T1 (sl) | 2008-08-31 |
| HK1104555A1 (en) | 2008-01-18 |
| DK1802581T3 (da) | 2008-06-30 |
| BRPI0516995A (pt) | 2008-09-30 |
| RU2007111704A (ru) | 2008-11-27 |
| ZA200703275B (en) | 2008-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121022 |