CA2579096C - Quinazoline derivatives as metabolically inert antifolate compounds - Google Patents
Quinazoline derivatives as metabolically inert antifolate compounds Download PDFInfo
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- CA2579096C CA2579096C CA2579096A CA2579096A CA2579096C CA 2579096 C CA2579096 C CA 2579096C CA 2579096 A CA2579096 A CA 2579096A CA 2579096 A CA2579096 A CA 2579096A CA 2579096 C CA2579096 C CA 2579096C
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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| US12048767B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
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| JP2830008B2 (ja) | 1988-04-01 | 1998-12-02 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体 |
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| US20030181635A1 (en) | 2002-03-22 | 2003-09-25 | Harry Kochat | Process for coupling amino acids to an antifolate scaffold |
| US20040092739A1 (en) * | 2002-11-13 | 2004-05-13 | Zejun Xiao | Process for synthesizing antifolates |
| US7060825B2 (en) | 2003-07-25 | 2006-06-13 | Bionumerik Pharmaceuticals, Inc. | Process for synthesizing 6-quinazolinyl-ethyl-benzoyl and related antifolates |
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| WO2006029385A2 (en) | 2004-09-08 | 2006-03-16 | Chelsea Therapeutics, Inc. | Quinazoline derivatives as metabolically inert antifolate compounds. |
| WO2006074416A1 (en) | 2005-01-07 | 2006-07-13 | Health Research Inc. | 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism |
-
2005
- 2005-09-08 WO PCT/US2005/032352 patent/WO2006029385A2/en not_active Ceased
- 2005-09-08 JP JP2007531414A patent/JP2008512490A/ja active Pending
- 2005-09-08 AU AU2005282241A patent/AU2005282241B2/en not_active Ceased
- 2005-09-08 US US11/223,433 patent/US7829708B2/en not_active Expired - Fee Related
- 2005-09-08 EP EP05806392A patent/EP1791544A4/en active Pending
- 2005-09-08 CA CA2579096A patent/CA2579096C/en not_active Expired - Fee Related
-
2010
- 2010-10-05 US US12/898,297 patent/US20110081338A1/en not_active Abandoned
- 2010-10-05 US US12/898,291 patent/US20110082149A1/en not_active Abandoned
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|---|---|
| US20060111272A1 (en) | 2006-05-25 |
| WO2006029385A3 (en) | 2006-05-11 |
| EP1791544A2 (en) | 2007-06-06 |
| US7829708B2 (en) | 2010-11-09 |
| US20110081338A1 (en) | 2011-04-07 |
| JP2008512490A (ja) | 2008-04-24 |
| AU2005282241B2 (en) | 2011-03-03 |
| US20110082149A1 (en) | 2011-04-07 |
| CA2579096A1 (en) | 2006-03-16 |
| EP1791544A4 (en) | 2007-09-12 |
| AU2005282241A1 (en) | 2006-03-16 |
| WO2006029385A2 (en) | 2006-03-16 |
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