CA2579096C - Quinazoline derivatives as metabolically inert antifolate compounds - Google Patents
Quinazoline derivatives as metabolically inert antifolate compounds Download PDFInfo
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- CA2579096C CA2579096C CA2579096A CA2579096A CA2579096C CA 2579096 C CA2579096 C CA 2579096C CA 2579096 A CA2579096 A CA 2579096A CA 2579096 A CA2579096 A CA 2579096A CA 2579096 C CA2579096 C CA 2579096C
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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| CN111801098A (zh) | 2018-02-21 | 2020-10-20 | 人工智能治疗公司 | 使用阿匹莫德和谷氨酸能剂的组合疗法 |
| CN112058287B (zh) * | 2020-08-25 | 2023-04-18 | 浙江工业大学 | 一种二维金属硒化物@MXene复合电催化剂的原位制备方法 |
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| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US5028554A (en) * | 1986-07-03 | 1991-07-02 | Oki Electric Industry Co., Ltd. | Process of fabricating an MIS FET |
| US4818753A (en) * | 1987-09-18 | 1989-04-04 | Sri International | Synthesis and method of use for 2, 4 diaminoquinazoline |
| JP2830008B2 (ja) | 1988-04-01 | 1998-12-02 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体 |
| US5248775A (en) * | 1989-12-11 | 1993-09-28 | The Trustees Of Princeton University | Pyrrolo(2,3-d)pyrimidines |
| US4996206A (en) * | 1989-12-11 | 1991-02-26 | The Trustees Of Princeton University | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives |
| KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| US4996207A (en) * | 1990-01-18 | 1991-02-26 | Nair Madhavan G | Three new non-polyglutamatable deazaaminopterins |
| US5073554A (en) * | 1990-01-18 | 1991-12-17 | Nair Madhavan G | Two non-polyglutamatable antifolates |
| US5508281A (en) * | 1991-04-08 | 1996-04-16 | Duquesne University Of The Holy Ghost | Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods of using these derivatives |
| AU3276793A (en) | 1991-12-20 | 1993-07-28 | Agouron Pharmaceuticals, Inc. | Antifolate quinazolines |
| IL108630A0 (en) * | 1993-02-18 | 1994-05-30 | Fmc Corp | Insecticidal substituted 2,4-diaminoquinazolines |
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| US5593999A (en) * | 1995-06-07 | 1997-01-14 | Nair; Madhavan G. | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) |
| EP1132395B1 (de) * | 1997-07-07 | 2003-10-29 | PTC Pharma AG | Verfahren zur Herstellung eines pharmazeutisch aktiven Peptides |
| US5912251A (en) * | 1998-01-17 | 1999-06-15 | Nair; Madhavan G. | Metabolically inert anti-inflammatory and anti-tumor antifolates |
| US6048736A (en) * | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
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| MXPA03004527A (es) * | 2000-11-28 | 2003-09-10 | Genentech Inc | Compuestos antagonicos lfa-1. |
| MXPA03009020A (es) | 2001-04-04 | 2004-02-17 | Bionumerik Pharmaceuticals Inc | Proceso para acoplar aminoacidos a estructura nuclear de antifolato. |
| US20030181635A1 (en) * | 2002-03-22 | 2003-09-25 | Harry Kochat | Process for coupling amino acids to an antifolate scaffold |
| US20040092739A1 (en) * | 2002-11-13 | 2004-05-13 | Zejun Xiao | Process for synthesizing antifolates |
| US7060825B2 (en) * | 2003-07-25 | 2006-06-13 | Bionumerik Pharmaceuticals, Inc. | Process for synthesizing 6-quinazolinyl-ethyl-benzoyl and related antifolates |
| US7612071B2 (en) * | 2004-03-12 | 2009-11-03 | Syntrix Biosystems, Inc. | Compositions and methods employing aminopterin |
| AU2005282241B2 (en) | 2004-09-08 | 2011-03-03 | Chelsea Therapeutics, Inc. | Quinazoline derivatives as metabolically inert antifolate compounds. |
| WO2006074416A1 (en) * | 2005-01-07 | 2006-07-13 | Health Research Inc. | 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism |
-
2005
- 2005-09-08 AU AU2005282241A patent/AU2005282241B2/en not_active Ceased
- 2005-09-08 JP JP2007531414A patent/JP2008512490A/ja active Pending
- 2005-09-08 EP EP05806392A patent/EP1791544A4/en active Pending
- 2005-09-08 US US11/223,433 patent/US7829708B2/en not_active Expired - Fee Related
- 2005-09-08 CA CA2579096A patent/CA2579096C/en not_active Expired - Fee Related
- 2005-09-08 WO PCT/US2005/032352 patent/WO2006029385A2/en not_active Ceased
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2010
- 2010-10-05 US US12/898,291 patent/US20110082149A1/en not_active Abandoned
- 2010-10-05 US US12/898,297 patent/US20110081338A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2579096A1 (en) | 2006-03-16 |
| US20110082149A1 (en) | 2011-04-07 |
| EP1791544A2 (en) | 2007-06-06 |
| AU2005282241B2 (en) | 2011-03-03 |
| AU2005282241A1 (en) | 2006-03-16 |
| JP2008512490A (ja) | 2008-04-24 |
| WO2006029385A3 (en) | 2006-05-11 |
| US7829708B2 (en) | 2010-11-09 |
| US20110081338A1 (en) | 2011-04-07 |
| US20060111272A1 (en) | 2006-05-25 |
| EP1791544A4 (en) | 2007-09-12 |
| WO2006029385A2 (en) | 2006-03-16 |
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