AU2005282241B2 - Quinazoline derivatives as metabolically inert antifolate compounds. - Google Patents

Quinazoline derivatives as metabolically inert antifolate compounds. Download PDF

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Publication number
AU2005282241B2
AU2005282241B2 AU2005282241A AU2005282241A AU2005282241B2 AU 2005282241 B2 AU2005282241 B2 AU 2005282241B2 AU 2005282241 A AU2005282241 A AU 2005282241A AU 2005282241 A AU2005282241 A AU 2005282241A AU 2005282241 B2 AU2005282241 B2 AU 2005282241B2
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Prior art keywords
disease
agents
alkyl
alkynyl
independently
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AU2005282241A
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AU2005282241A1 (en
Inventor
Simon Pedder
Michael J. Roberts
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Lundbeck NA Ltd
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Chelsea Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
AU2005282241A 2004-09-08 2005-09-08 Quinazoline derivatives as metabolically inert antifolate compounds. Ceased AU2005282241B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60788304P 2004-09-08 2004-09-08
US60/607,883 2004-09-08
US61148204P 2004-09-20 2004-09-20
US60/611,482 2004-09-20
PCT/US2005/032352 WO2006029385A2 (en) 2004-09-08 2005-09-08 Quinazoline derivatives as metabolically inert antifolate compounds.

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011202657A Division AU2011202657A1 (en) 2004-09-08 2011-06-03 Quinazoline derivatives as metabolically inert antifolate compounds

Publications (2)

Publication Number Publication Date
AU2005282241A1 AU2005282241A1 (en) 2006-03-16
AU2005282241B2 true AU2005282241B2 (en) 2011-03-03

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Application Number Title Priority Date Filing Date
AU2005282241A Ceased AU2005282241B2 (en) 2004-09-08 2005-09-08 Quinazoline derivatives as metabolically inert antifolate compounds.

Country Status (6)

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US (3) US7829708B2 (enExample)
EP (1) EP1791544A4 (enExample)
JP (1) JP2008512490A (enExample)
AU (1) AU2005282241B2 (enExample)
CA (1) CA2579096C (enExample)
WO (1) WO2006029385A2 (enExample)

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