CA2573754C - Substituted amino compounds as 5-ht/na uptake inhibitors - Google Patents

Substituted amino compounds as 5-ht/na uptake inhibitors Download PDF

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Publication number
CA2573754C
CA2573754C CA2573754A CA2573754A CA2573754C CA 2573754 C CA2573754 C CA 2573754C CA 2573754 A CA2573754 A CA 2573754A CA 2573754 A CA2573754 A CA 2573754A CA 2573754 C CA2573754 C CA 2573754C
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CA
Canada
Prior art keywords
substituted amino
formula
compound
amino compound
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2573754A
Other languages
English (en)
French (fr)
Other versions
CA2573754A1 (en
Inventor
Petra Bloms-Funke
Elmar Josef Friderichs
Ivars Graudums
Hagen-Heinrich Hennies
Achim Kless
Klaus Schiene
Oswald Zimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grünenthal GmbH
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CA2573754A1 publication Critical patent/CA2573754A1/en
Application granted granted Critical
Publication of CA2573754C publication Critical patent/CA2573754C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Hybrid Cells (AREA)
  • Secondary Cells (AREA)
  • Glass Compositions (AREA)
  • Emergency Protection Circuit Devices (AREA)
CA2573754A 2004-07-16 2005-07-12 Substituted amino compounds as 5-ht/na uptake inhibitors Expired - Fee Related CA2573754C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004034619A DE102004034619A1 (de) 2004-07-16 2004-07-16 Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102004034619.4 2004-07-16
PCT/EP2005/007537 WO2006008032A1 (de) 2004-07-16 2005-07-12 Substituierte aminoverbindungen als 5-ht/na uptakehemmer

Publications (2)

Publication Number Publication Date
CA2573754A1 CA2573754A1 (en) 2006-01-26
CA2573754C true CA2573754C (en) 2012-04-24

Family

ID=35064779

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2573754A Expired - Fee Related CA2573754C (en) 2004-07-16 2005-07-12 Substituted amino compounds as 5-ht/na uptake inhibitors

Country Status (13)

Country Link
US (1) US7342133B2 (enExample)
EP (1) EP1768948B1 (enExample)
JP (1) JP4926956B2 (enExample)
AT (1) ATE396169T1 (enExample)
CA (1) CA2573754C (enExample)
CY (1) CY1110436T1 (enExample)
DE (2) DE102004034619A1 (enExample)
DK (1) DK1768948T3 (enExample)
ES (1) ES2308514T3 (enExample)
PL (1) PL1768948T3 (enExample)
PT (1) PT1768948E (enExample)
SI (1) SI1768948T1 (enExample)
WO (1) WO2006008032A1 (enExample)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
JPS598259B2 (ja) * 1976-01-01 1984-02-23 武田薬品工業株式会社 新規シクロヘキセン誘導体
US20050090553A1 (en) * 1992-06-30 2005-04-28 Shapiro Howard K. Compositions and method for treatment of chronic inflammatory diseases
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
DE19857475A1 (de) * 1998-12-14 2000-06-15 Gruenenthal Gmbh Substituierte Cycloheptene, deren Herstellung und Verwendung
DE19915601A1 (de) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
DE10033459A1 (de) 2000-07-10 2002-01-24 Gruenenthal Gmbh Cyclische substituierte Aminomethylverbindungen und diese Verbindungen enthaltende Arzeimittel
DE10132747A1 (de) * 2001-07-05 2003-01-23 Gruenenthal Gmbh Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen
ES2291891T3 (es) * 2003-07-03 2008-03-01 F. Hoffmann-La Roche Ag Antagonistas duales de nk1/nk3 para tratamiento de esquizofrenia.

Also Published As

Publication number Publication date
PL1768948T3 (pl) 2008-10-31
DE102004034619A1 (de) 2006-02-23
CY1110436T1 (el) 2015-04-29
JP2008506645A (ja) 2008-03-06
PT1768948E (pt) 2008-07-10
ATE396169T1 (de) 2008-06-15
EP1768948A1 (de) 2007-04-04
EP1768948B1 (de) 2008-05-21
ES2308514T3 (es) 2008-12-01
SI1768948T1 (sl) 2008-10-31
WO2006008032A1 (de) 2006-01-26
JP4926956B2 (ja) 2012-05-09
US20070185212A1 (en) 2007-08-09
DK1768948T3 (da) 2008-09-15
CA2573754A1 (en) 2006-01-26
DE502005004207D1 (de) 2008-07-03
US7342133B2 (en) 2008-03-11

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Effective date: 20140714