CA2569864A1 - Ifbm's to promote attachment of target analytes - Google Patents
Ifbm's to promote attachment of target analytes Download PDFInfo
- Publication number
- CA2569864A1 CA2569864A1 CA002569864A CA2569864A CA2569864A1 CA 2569864 A1 CA2569864 A1 CA 2569864A1 CA 002569864 A CA002569864 A CA 002569864A CA 2569864 A CA2569864 A CA 2569864A CA 2569864 A1 CA2569864 A1 CA 2569864A1
- Authority
- CA
- Canada
- Prior art keywords
- ifbm
- implant
- peptide
- binding
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Paints Or Removers (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2742202A CA2742202A1 (en) | 2004-06-16 | 2005-06-15 | Ifbm's to promote the specific attachment of target analytes to the surface of orthopedic implants |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58001904P | 2004-06-16 | 2004-06-16 | |
| US60/580,019 | 2004-06-16 | ||
| US65133805P | 2005-02-09 | 2005-02-09 | |
| US60/651,338 | 2005-02-09 | ||
| US65174705P | 2005-02-10 | 2005-02-10 | |
| US60/651,747 | 2005-02-10 | ||
| PCT/US2005/021270 WO2006098744A2 (en) | 2004-06-16 | 2005-06-15 | Ifbm’s to promote attachment of target analytes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2742202A Division CA2742202A1 (en) | 2004-06-16 | 2005-06-15 | Ifbm's to promote the specific attachment of target analytes to the surface of orthopedic implants |
Publications (1)
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| CA2569864A1 true CA2569864A1 (en) | 2006-09-21 |
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Family Applications (1)
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|---|---|---|---|
| CA002569864A Abandoned CA2569864A1 (en) | 2004-06-16 | 2005-06-15 | Ifbm's to promote attachment of target analytes |
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| US (15) | US7572766B2 (enExample) |
| EP (4) | EP1771214A2 (enExample) |
| JP (1) | JP2008504850A (enExample) |
| AT (1) | ATE462451T1 (enExample) |
| CA (1) | CA2569864A1 (enExample) |
| DE (1) | DE602005020320D1 (enExample) |
| ES (1) | ES2342551T3 (enExample) |
| WO (2) | WO2006007368A2 (enExample) |
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| WO2005007819A2 (en) * | 2003-07-09 | 2005-01-27 | Wisconsin Alumni Research Foundation | Charge-dynamic polymers and delivery of anionic compounds |
| ES2438190T3 (es) * | 2003-07-30 | 2014-01-16 | Japan Science And Technology Agency | Péptido susceptible de unirse a titanio, plata y silicona |
| DE602005020320D1 (de) | 2004-06-16 | 2010-05-12 | Affinergy Inc | Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten |
| US20070099245A1 (en) * | 2005-09-29 | 2007-05-03 | Boris Gorovits | Assays for neutralizing antibodies |
| US7807624B2 (en) * | 2006-01-11 | 2010-10-05 | Affinergy, Inc. | Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices |
| US20080015138A1 (en) * | 2006-07-17 | 2008-01-17 | Affinergy, Inc. | Metal binding compounds, metal binding compositions, and their uses |
| EP2089072B1 (en) * | 2006-09-06 | 2014-06-04 | Boston Scientific Limited | Medical devices having a coating for promoting endothelial cell adhesion |
| US8834918B2 (en) * | 2007-01-22 | 2014-09-16 | Wisconsin Alumni Research Foundation | Modified multilayered film |
| WO2008100865A1 (en) * | 2007-02-13 | 2008-08-21 | Nye Paul H | A personal affector machine |
| EP2142231B1 (en) * | 2007-03-15 | 2014-09-17 | Boston Scientific Limited | A stent comprising surface-binding cell adhesion polypeptides and a method for coating a stent |
| US7977313B2 (en) * | 2007-04-27 | 2011-07-12 | Affinergy, Inc. | Methods and compositions for promoting localization of pharmaceutically active agents to bone |
| JP5642540B2 (ja) * | 2007-06-01 | 2014-12-17 | アロウ・インターナショナル・インコーポレイテッドＡｒｒｏｗ Ｉｎｔｅｒｎａｔｉｏｎａｌ， Ｉｎｃ． | 組み合わされた線維素溶解性および抗菌性のカテーテル、およびその使用 |
| JP2009051773A (ja) * | 2007-08-27 | 2009-03-12 | Toyobo Co Ltd | 細胞接着能を有するｈｓｐ７０ファミリータンパク質 |
| WO2009032943A2 (en) * | 2007-09-04 | 2009-03-12 | Affinergy, Inc. | Methods and compositions for delivery of growth factor to fibrous connective tissue |
| WO2009049100A2 (en) * | 2007-10-09 | 2009-04-16 | Wisconsin Alumni Research Foundation | Ultrathin multilayered films for controlled release of anionic reagents |
| US8071210B2 (en) * | 2007-10-09 | 2011-12-06 | Wiscousin Alumni Research Foundation | Covalent assembly of ultrathin polymeric films |
| CA2703482C (en) * | 2007-10-22 | 2015-12-15 | Affinergy, Inc. | Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces |
| WO2009054967A2 (en) * | 2007-10-22 | 2009-04-30 | Synthes (U.S.A.) | Compositions for delivery of glycopeptide antibiotics |
| US8637455B2 (en) | 2007-10-22 | 2014-01-28 | Affinergy, Llc | Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces |
| US20090246250A1 (en) * | 2008-03-27 | 2009-10-01 | Affinergy | Coating compositions having improved performance |
| US8324333B2 (en) | 2008-06-05 | 2012-12-04 | Wisconsin Alumni Research Foundation | Anionic charge-dynamic polymers for release of cationic agents |
| CN102176882A (zh) * | 2008-08-07 | 2011-09-07 | 生物活性外科公司 | 医疗器械和植入物的干细胞捕获和固定涂层 |
| US7700923B2 (en) * | 2008-09-20 | 2010-04-20 | Varian Medical Systems, Inc. | Apparatus of photoconductor crystal growth |
| KR101594202B1 (ko) | 2008-09-24 | 2016-02-15 | 텔 하쇼머 메디컬 리서치 인프라스트럭쳐 앤드 서비시스 리미티드． | 세포 유착 방지를 위한 펩티드와 조성물 및 그것의 사용 방법 |
| US20100098737A1 (en) * | 2008-10-17 | 2010-04-22 | Affinergy, Inc. | methods and compositions for delivery of glycopeptide antibiotics to medical device surfaces |
| WO2010081201A1 (en) * | 2009-01-19 | 2010-07-22 | Cochlear Limited | Surface modification for implantable medical device |
| KR101245929B1 (ko) | 2009-01-20 | 2013-03-22 | 호메이욘 에이치. 자데흐 | 항체 매개된 골질 재생 |
| US9333280B2 (en) | 2009-02-25 | 2016-05-10 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
| US8545459B2 (en) * | 2009-02-25 | 2013-10-01 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
| US8574612B2 (en) * | 2009-03-04 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having a coating of biologic macromolecules |
| US20100249783A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Drug-eluting implant cover |
| US9414864B2 (en) | 2009-04-15 | 2016-08-16 | Warsaw Orthopedic, Inc. | Anterior spinal plate with preformed drug-eluting device affixed thereto |
| US9078712B2 (en) * | 2009-04-15 | 2015-07-14 | Warsaw Orthopedic, Inc. | Preformed drug-eluting device to be affixed to an anterior spinal plate |
| US8079737B2 (en) * | 2009-04-20 | 2011-12-20 | Harvatek Corporation | Reflection-type light-emitting module with high heat-dissipating and high light-generating efficiency |
| WO2011060076A1 (en) * | 2009-11-10 | 2011-05-19 | Amgen Inc. | Anti-c-mpl antibodies |
| US20110117171A1 (en) * | 2009-11-18 | 2011-05-19 | Affinergy, Inc. | Implantable bone graft materials |
| CN102858793B (zh) * | 2010-03-16 | 2015-04-29 | 先进科技及再生医学有限责任公司 | Bmp-2亲和肽 |
| US11628267B2 (en) | 2010-08-04 | 2023-04-18 | Medline Industries, Lp | Universal medical gas delivery system |
| US8707950B1 (en) * | 2010-08-04 | 2014-04-29 | Darren Rubin | Universal medical gas delivery system |
| US9186243B2 (en) * | 2011-05-31 | 2015-11-17 | Novartis Ag | Accommodative intraocular lens and method of implantation |
| US9586381B1 (en) | 2013-10-25 | 2017-03-07 | Steriplate, LLC | Metal plated object with biocidal properties |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| WO2016176146A1 (en) * | 2015-04-26 | 2016-11-03 | The Trustees Of Princeton University | Surfaces comprising attached quorum sensing modulators |
| EP3442519A4 (en) | 2016-04-14 | 2019-12-04 | Azura Opthalmics Ltd. | SELDISULFID COMPOSITIONS FOR USE IN THE TREATMENT OF THE MEIBOM DRESSING DYSFUNCTION |
| US9999899B2 (en) | 2016-11-01 | 2018-06-19 | International Business Machines Corporation | Controlled exposure of in-vivo sensors |
| EP3796941A4 (en) * | 2018-05-30 | 2022-12-28 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| EP3810637A1 (en) * | 2018-06-20 | 2021-04-28 | DWI - Leibniz-Institut für Interaktive Materialien e.V. | Fusion peptides or proteins, their use, and systems and kits based thereupon, for the separation and/or detection of plastics, particularly of microplastics |
| BR112021006752A2 (pt) | 2018-10-12 | 2021-07-13 | Theradaptive, Inc. | polipeptídeos incluindo uma sequência de ligação de betafosfato tricálcico e usos dos mesmos |
| JP7723603B2 (ja) | 2019-04-12 | 2025-08-14 | アズーラ オフサルミックス エルティーディー． | コンタクトレンズ不快感を処置するための組成物および方法 |
| US11583408B2 (en) * | 2019-05-18 | 2023-02-21 | Anjali Investments Llc | Minimally invasive posterior cervical facet arthrodesis shim implant and tools therefor |
| US20210154403A1 (en) * | 2019-11-25 | 2021-05-27 | Thomas Leroy Schmitz | Joint capsule fluid delivery |
| CN115279458A (zh) | 2020-01-10 | 2022-11-01 | 阿祖拉眼科有限公司 | 组合物和敏感性说明 |
| WO2021211683A2 (en) | 2020-04-15 | 2021-10-21 | Theradaptive, Inc. | Compositions and methods for targeted therapeutic delivery to bone |
| WO2021222321A1 (en) * | 2020-04-27 | 2021-11-04 | Board Of Trustees Of The University Of Arkansas | Cellulose based anti-viral anti-microbial spray coating |
| US11141528B1 (en) | 2020-12-14 | 2021-10-12 | Thomas Leroy Schmitz | Therapeutic fluid delivery cartridge |
| US12357361B2 (en) * | 2021-04-15 | 2025-07-15 | Jeremy M. Gililland | Knee sizing tool and systems and methods for use in total knee replacement procedure |
| WO2025106439A1 (en) | 2023-11-13 | 2025-05-22 | Theradaptive, Inc. | Living bioreactor compositions and methods of use |
| CN118910022B (zh) * | 2024-08-19 | 2025-10-24 | 中国人民解放军陆军军医大学 | 一种抗辐射多肽及其应用 |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA92121A (en) | 1904-11-07 | 1905-03-14 | William Waid Paddock | Pressure filter |
| US4244946A (en) | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| FR2501680A1 (fr) | 1981-03-12 | 1982-09-17 | Elf Aquitaine | Synthese de tetra mercaptides stanniques |
| US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
| US4442133A (en) * | 1982-02-22 | 1984-04-10 | Greco Ralph S | Antibiotic bonding of vascular prostheses and other implants |
| US5217492A (en) * | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
| US4526909A (en) | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
| US4563489A (en) | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| US5866363A (en) * | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
| US5079342A (en) * | 1986-01-22 | 1992-01-07 | Institut Pasteur | Cloned DNA sequences related to the entire genomic RNA of human immunodeficiency virus II (HIV-2), polypeptides encoded by these DNA sequences and use of these DNA clones and polypeptides in diagnostic kits |
| US5543394A (en) | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
| GB2215209B (en) | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
| US5344654A (en) | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5019393A (en) * | 1988-08-03 | 1991-05-28 | New England Deaconess Hospital Corporation | Biocompatible substance with thromboresistance |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US6261271B1 (en) | 1989-01-18 | 2001-07-17 | Becton Dickinson And Company | Anti-infective and antithrombogenic medical articles and method for their preparation |
| US5356630A (en) | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| JPH0327172A (ja) | 1989-06-19 | 1991-02-05 | Nissan Chem Ind Ltd | 布の漂白方法 |
| US5635482A (en) * | 1989-08-14 | 1997-06-03 | The Regents Of The University Of California | Synthetic compounds and compositions with enhanced cell binding |
| US5236456A (en) | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| DE4002897A1 (de) | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US5747334A (en) * | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| AP237A (en) | 1990-05-29 | 1993-04-29 | Cedars Sinai Medical Center | Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use. |
| US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
| US5520664A (en) | 1991-03-01 | 1996-05-28 | Spire Corporation | Catheter having a long-lasting antimicrobial surface treatment |
| US5652118A (en) | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | Nucleic acid encoding a novel morphogenic protein, OP-3 |
| MX9203083A (es) | 1991-06-21 | 1994-08-31 | Genetics Inst | Formulaciones farmaceuticas de proteinas osteogenicas. |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5217493A (en) * | 1992-03-11 | 1993-06-08 | Board Of Regents, The University Of Texas System | Antibacterial coated medical implants |
| US5681575A (en) | 1992-05-19 | 1997-10-28 | Westaim Technologies Inc. | Anti-microbial coating for medical devices |
| EP0628078B1 (en) * | 1992-12-11 | 1999-12-08 | The Dow Chemical Company | Multivalent single chain antibodies |
| WO1995000547A1 (en) * | 1993-06-22 | 1995-01-05 | E.I. Du Pont De Nemours And Company | Antimicrobial composition of a polymer and a peptide forming amphiphilic helices of the magainin-type |
| US6361526B1 (en) | 1993-11-01 | 2002-03-26 | Medtronic Xomed, Inc. | Antimicrobial tympanostomy tube |
| ES2249767T3 (es) * | 1994-03-04 | 2006-04-01 | Ajinomoto Co., Inc. | Procedimiento para producir l-lisina. |
| US5824483A (en) | 1994-05-18 | 1998-10-20 | Pence Inc. | Conformationally-restricted combinatiorial library composition and method |
| JPH07313169A (ja) * | 1994-05-26 | 1995-12-05 | Nippon Ham Kk | 骨形成因子受容体改変体の遺伝子 |
| AU3719395A (en) | 1994-09-21 | 1996-04-09 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
| US6746482B2 (en) * | 1994-10-17 | 2004-06-08 | Baxter International Inc. | Method for producing medical devices and devices so produced |
| JP3659261B2 (ja) * | 1994-10-20 | 2005-06-15 | モルフォシス・アクチェンゲゼルシャフト | 組換体タンパク質の多機能性複合体への標的化ヘテロ結合 |
| DE4441124C2 (de) | 1994-11-18 | 1997-03-27 | Heraeus Kulzer Gmbh | Verfahren zur Erzeugung eines haftfesten, feuchtigkeitsdichten Überzugs aus Kunststoff auf einer Unterlage und dessen Verwendung |
| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| AUPN024994A0 (en) * | 1994-12-23 | 1995-01-27 | Ludwig Institute For Cancer Research | Assay and peptides for use therein |
| US5817748A (en) * | 1995-03-17 | 1998-10-06 | The Research Foundation Of State University Of New York | Mimotopes of human Platelet glycoprotein Ib/IX |
| US5624704A (en) | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
| US5702892A (en) | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| US5622699A (en) * | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
| US5709672A (en) | 1995-11-01 | 1998-01-20 | Texas Tech University Health Sciences Center | Silastic and polymer-based catheters with improved antimicrobial/antifungal properties |
| IE80466B1 (en) * | 1995-11-10 | 1998-07-29 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| FR2741892B1 (fr) | 1995-12-04 | 1998-02-13 | Pasteur Merieux Serums Vacc | Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus |
| US6031071A (en) | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
| EP0800901B1 (de) | 1996-04-10 | 2003-07-02 | Dieffenbacher Schenck Panel GmbH | Verfahren zur Herstellung eines Vlieses und Vorrichtung |
| CN1155714C (zh) * | 1996-09-04 | 2004-06-30 | 辛根塔默根有限公司 | 抗真菌蛋白及其编码dna和掺入此dna的宿主 |
| US6617114B1 (en) * | 1996-10-31 | 2003-09-09 | Karo Bio Ab | Identification of drug complementary combinatorial libraries |
| US5756332A (en) * | 1996-12-26 | 1998-05-26 | Incyte Pharmaceuticals, Inc. | Guanosine monophosphate reductase |
| WO2001021658A1 (en) * | 1999-09-24 | 2001-03-29 | Human Genome Sciences, Inc. | 32 human secreted proteins |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| WO1998052619A2 (de) | 1997-05-22 | 1998-11-26 | Merck Patent Gmbh | Peptid-beschichtete implantate und verfahren zu ihrer herstellung |
| EP1056760A4 (en) * | 1998-02-26 | 2003-03-05 | Human Genome Sciences Inc | PROTEINS SECRETED BY MAN |
| US6281331B1 (en) | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6121236A (en) * | 1998-03-24 | 2000-09-19 | The Children's Medical Center Corporation | Multivalent ligands which modulate angiogenesis |
| US7208011B2 (en) | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
| US6428579B1 (en) * | 1998-07-01 | 2002-08-06 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
| US6780582B1 (en) * | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
| WO2000004941A1 (en) * | 1998-07-24 | 2000-02-03 | Pharmacal Biotechnologies, Inc. | Osseous tissue reconstruction system and method |
| US20030236190A1 (en) * | 1998-09-02 | 2003-12-25 | Renuka Pillutla | Isulin and IGF-1 receptor agonists and antagonists |
| US7176275B2 (en) * | 1998-09-04 | 2007-02-13 | Samuel Bogoch | Anthrax and small pox replikins and methods of use |
| EP1135405A4 (en) * | 1998-11-20 | 2002-10-29 | Vincent Guerriero | BY DNA-CODED PROTEINS THAT INHIBIT THE FUNCTION OF Hsp70 |
| US7090973B1 (en) * | 1999-04-09 | 2006-08-15 | Oscient Pharmaceuticals Corporation | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics |
| WO2000065352A1 (en) * | 1999-04-28 | 2000-11-02 | Eidgenossisch Technische Hochschule Zurich | Polyionic coatings in analytic and sensor devices |
| US6544768B1 (en) * | 1999-05-11 | 2003-04-08 | Cornell Research Foundation, Inc. | Mammalian soluble adenylyl cyclase |
| JP2003510024A (ja) * | 1999-08-09 | 2003-03-18 | インサイト・ゲノミックス・インコーポレイテッド | プロテアーゼ及びプロテアーゼインヒビター |
| US7304127B2 (en) * | 1999-08-27 | 2007-12-04 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use |
| US7592304B2 (en) * | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| WO2001056627A1 (en) * | 2000-01-12 | 2001-08-09 | Am-Pharma B.V. | Medical device coated with antimicrobial peptides |
| US20030229393A1 (en) * | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
| KR100860860B1 (ko) * | 2000-03-15 | 2008-09-29 | 오르버스네이치 메디칼 인코포레이티드 | 내피 세포 부착을 촉진하는 코팅 |
| WO2001075179A2 (en) * | 2000-03-31 | 2001-10-11 | Ludwig Institute For Cancer Research | Preprocalcitonin as tumor rejection antigen precursor and uses thereof |
| EP1142596A1 (en) * | 2000-04-03 | 2001-10-10 | Universiteit Gent | Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants |
| US20110131679A2 (en) * | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| US6716811B1 (en) * | 2000-07-20 | 2004-04-06 | Affymax, Inc. | Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses |
| WO2002012271A2 (en) * | 2000-08-04 | 2002-02-14 | Jeffrey Howard | Treatment of microbial infections with bacterial proteins and peptides |
| DE10040105A1 (de) * | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften |
| EP1311664A2 (en) * | 2000-08-21 | 2003-05-21 | Incyte Genomics, Inc. | Microtubule-associated proteins and tubulins |
| WO2002028408A2 (en) * | 2000-10-02 | 2002-04-11 | Arizeke Pharmaceuticals, Inc. | Compositions and methods for the transport of biologically active agents across cellular barriers |
| EP1399583A4 (en) * | 2000-10-27 | 2004-09-08 | Diadexus Inc | COMPOSITIONS AND METHODS RELATING TO BREAST-SPECIFIC GENES AND PROTEINS |
| US20030003440A1 (en) * | 2001-03-14 | 2003-01-02 | Lucia Lopalco | Novel CCR5 epitope and antibodies against it |
| WO2002100426A1 (en) * | 2001-06-08 | 2002-12-19 | Smith & Nephew Plc | Bmp binding proteins for use in bone or cartilage regeneration |
| JP2005502335A (ja) * | 2001-08-08 | 2005-01-27 | インサイト・ゲノミックス・インコーポレイテッド | 細胞成長、分化および細胞死関連タンパク質 |
| WO2003014145A2 (en) | 2001-08-10 | 2003-02-20 | Novartis Ag | Peptides that bind to atherosclerotic lesions |
| JP4933708B2 (ja) | 2001-08-31 | 2012-05-16 | 善彦 西村 | 骨形成作用を有する新規なペプチドおよびこれを固定化してなる骨形成促進剤 |
| US6596338B2 (en) | 2001-10-24 | 2003-07-22 | Howmedica Osteonics Corp. | Antibiotic calcium phosphate coating |
| EP1527341B1 (en) * | 2001-11-20 | 2009-06-17 | Duke University | Interfacial biomaterials |
| US7381426B2 (en) * | 2002-01-24 | 2008-06-03 | Southwest Research Institute | Targeted delivery of bioactive factors to the systemic skeleton |
| US7355022B2 (en) * | 2002-02-12 | 2008-04-08 | Licentia Ltd. | Gene functionally related to dyslexia |
| AU2003213246A1 (en) * | 2002-02-21 | 2003-09-09 | University Of Virginia Patent Foundation | Bone targeting peptides |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| DK1495330T3 (da) * | 2002-04-12 | 2009-05-18 | Brian F O'dowd | Fremgangsmåde til at identificere forbindelser, som påvirker transmembran-proteiner |
| ATE479705T1 (de) * | 2002-05-03 | 2010-09-15 | Mayo Foundation | Reduzierter slam abhängiger zell eintritt |
| CA2489009A1 (en) * | 2002-05-03 | 2003-11-13 | Millenium Biologix Inc. | Connective tissue stimulating peptides |
| US7449480B2 (en) * | 2002-05-14 | 2008-11-11 | Baylor College Of Medicine | Small molecule inhibitors of HER2 expression |
| JP2005185101A (ja) | 2002-05-30 | 2005-07-14 | National Institute Of Agrobiological Sciences | 植物の全長ｃＤＮＡおよびその利用 |
| US7166574B2 (en) * | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| AU2003301298A1 (en) * | 2002-09-04 | 2004-05-04 | Board Of Regents, University Of Texas System | Composition, method and use of bi-functional biomaterials |
| US7238669B2 (en) | 2002-09-11 | 2007-07-03 | The Curators Of The University Of Missouri | Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae |
| US7282214B2 (en) | 2002-12-19 | 2007-10-16 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial coatings |
| US7163920B2 (en) * | 2003-09-30 | 2007-01-16 | Ethicon, Inc. | Peptide with osteogenic activity |
| US8188219B2 (en) | 2004-01-28 | 2012-05-29 | The Regents Of The University Of California | Bone morphogenic protein binding peptide |
| US7528105B1 (en) * | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
| KR101013999B1 (ko) * | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
| DE602005020320D1 (de) | 2004-06-16 | 2010-05-12 | Affinergy Inc | Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten |
| US7807624B2 (en) | 2006-01-11 | 2010-10-05 | Affinergy, Inc. | Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices |
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2005
- 2005-06-15 DE DE602005020320T patent/DE602005020320D1/de not_active Expired - Lifetime
- 2005-06-15 WO PCT/US2005/021147 patent/WO2006007368A2/en not_active Ceased
- 2005-06-15 US US11/152,974 patent/US7572766B2/en not_active Expired - Fee Related
- 2005-06-15 EP EP05786727A patent/EP1771214A2/en not_active Withdrawn
- 2005-06-15 EP EP10177135A patent/EP2255832A3/en not_active Withdrawn
- 2005-06-15 US US11/153,143 patent/US20060051396A1/en not_active Abandoned
- 2005-06-15 WO PCT/US2005/021270 patent/WO2006098744A2/en not_active Ceased
- 2005-06-15 CA CA002569864A patent/CA2569864A1/en not_active Abandoned
- 2005-06-15 EP EP09173344A patent/EP2138195A3/en not_active Withdrawn
- 2005-06-15 EP EP05857694A patent/EP1793875B9/en not_active Expired - Lifetime
- 2005-06-15 ES ES05857694T patent/ES2342551T3/es not_active Expired - Lifetime
- 2005-06-15 AT AT05857694T patent/ATE462451T1/de not_active IP Right Cessation
- 2005-06-15 JP JP2007516728A patent/JP2008504850A/ja active Pending
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2006
- 2006-12-14 US US11/638,973 patent/US7608581B2/en not_active Expired - Fee Related
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2009
- 2009-06-17 US US12/486,099 patent/US7795383B2/en not_active Expired - Fee Related
- 2009-06-17 US US12/486,505 patent/US7790844B2/en not_active Expired - Fee Related
- 2009-06-18 US US12/487,135 patent/US7786256B2/en not_active Expired - Fee Related
- 2009-06-19 US US12/488,183 patent/US7812119B2/en not_active Expired - Fee Related
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2010
- 2010-08-30 US US12/871,194 patent/US8022183B2/en not_active Expired - Fee Related
- 2010-08-30 US US12/871,570 patent/US7994277B2/en not_active Expired - Fee Related
- 2010-08-30 US US12/871,231 patent/US8022184B2/en not_active Expired - Fee Related
- 2010-08-31 US US12/872,005 patent/US8030452B2/en not_active Expired - Fee Related
- 2010-08-31 US US12/872,031 patent/US7968677B2/en not_active Expired - Fee Related
- 2010-08-31 US US12/871,983 patent/US8022185B2/en not_active Expired - Fee Related
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2011
- 2011-07-01 US US13/174,884 patent/US20110263499A1/en not_active Abandoned
- 2011-07-01 US US13/175,123 patent/US20110269687A1/en not_active Abandoned
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