CA2567655C - Binding moieties based on shark ignar domains - Google Patents
Binding moieties based on shark ignar domains Download PDFInfo
- Publication number
- CA2567655C CA2567655C CA2567655A CA2567655A CA2567655C CA 2567655 C CA2567655 C CA 2567655C CA 2567655 A CA2567655 A CA 2567655A CA 2567655 A CA2567655 A CA 2567655A CA 2567655 C CA2567655 C CA 2567655C
- Authority
- CA
- Canada
- Prior art keywords
- domain
- atom
- remark
- loop
- domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57584504P | 2004-06-02 | 2004-06-02 | |
US60/575,845 | 2004-06-02 | ||
PCT/AU2005/000789 WO2005118629A1 (en) | 2004-06-02 | 2005-06-02 | BINDING MOIETIES BASED ON SHARK IgNAR DOMAINS |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2567655A1 CA2567655A1 (en) | 2005-12-15 |
CA2567655C true CA2567655C (en) | 2015-06-30 |
Family
ID=35462883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2567655A Active CA2567655C (en) | 2004-06-02 | 2005-06-02 | Binding moieties based on shark ignar domains |
Country Status (7)
Country | Link |
---|---|
US (3) | US7977071B2 (ja) |
EP (3) | EP2330120A3 (ja) |
JP (2) | JP2008511286A (ja) |
AU (3) | AU2005250055B2 (ja) |
CA (1) | CA2567655C (ja) |
DK (2) | DK2330121T3 (ja) |
WO (1) | WO2005118629A1 (ja) |
Families Citing this family (69)
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US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2008134461A2 (en) | 2007-04-27 | 2008-11-06 | Dow Global Technologies, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2009004065A2 (en) | 2007-07-03 | 2009-01-08 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating cdr and/or fr positions |
WO2009026638A1 (en) * | 2007-08-31 | 2009-03-05 | Melbourne Health | Marine-animal derived therapeutic and diagnostic agents for hepatitis b |
JP2011529171A (ja) | 2008-07-25 | 2011-12-01 | セレスティス リミテッド | 診断方法 |
US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
US20100092470A1 (en) * | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
WO2010040175A1 (en) * | 2008-10-06 | 2010-04-15 | Commonwealth Scientific And Industrial Research Organisation | Amyloid-beta peptide crystal structure |
EP2427489B1 (en) | 2009-05-07 | 2015-04-22 | Novozymes Biopharma DK A/S | Method of controlling o-linked glycosylation of antibodies |
EP2448966B1 (en) | 2009-07-03 | 2018-11-14 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them |
WO2011056056A2 (es) | 2009-11-04 | 2011-05-12 | Laboratorios Silanes, S.A. De C.V. | Dominios vhnar anti -citocinas |
US9459253B2 (en) | 2009-12-23 | 2016-10-04 | Cellestis Limited | Assay for measuring cell-mediated immunoresponsiveness |
AU2010336029B2 (en) | 2009-12-23 | 2011-10-13 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
WO2012122590A1 (en) | 2011-03-14 | 2012-09-20 | Cellmid Limited | Antibody recognizing n-domain of midkine |
EP2702165B1 (en) | 2011-04-29 | 2017-03-22 | Cellestis Limited | An assay of cell mediated immune responsiveness |
AU2012269720B2 (en) | 2011-06-13 | 2015-01-22 | Csl Limited | Antibodies against G-CSFR and uses thereof |
EP3351936A1 (en) | 2011-06-29 | 2018-07-25 | Cellestis Limited | A cell mediated immune response assay with enhanced sensitivity |
CA2852709A1 (en) | 2011-10-28 | 2013-05-02 | Patrys Limited | Pat-lm1 epitopes and methods for using same |
US10112987B2 (en) * | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
US10112988B2 (en) * | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
WO2013106485A2 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
MX347154B (es) * | 2012-02-24 | 2017-02-21 | Centro De Investigación Científica Y De Educación Superior De Ensenada Baja California (Cicese) | Prueba de diagnóstico para enfermedades infecciosas en ganado bovino. |
US20130302250A1 (en) | 2012-05-07 | 2013-11-14 | The University Court Of The University Of Aberdeen | Single domain binding molecule |
WO2014100853A1 (en) | 2012-12-28 | 2014-07-03 | Cellestis Limited | A cell mediated immune response assay |
CN105073781A (zh) | 2013-01-11 | 2015-11-18 | 加州生物医学研究所 | 牛融合抗体 |
WO2014122144A1 (en) | 2013-02-05 | 2014-08-14 | Engmab Ag | BISPECIFIC ANTIBODIES AGAINST CD3ε AND BCMA |
EP2762496A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
JP6545105B2 (ja) | 2013-02-07 | 2019-07-17 | シーエスエル、リミテッド | Il−11r結合タンパク質及びその使用 |
EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
RU2015146419A (ru) | 2013-04-23 | 2017-05-26 | Зе Юниверсити Корт Оф Зе Юниверсити Оф Абердин | Выделение терапевтических доменов vnar, специфичных по отношению к мишени icosl |
DK3074038T3 (en) | 2013-11-28 | 2019-03-11 | Csl Ltd | METHOD OF TREATING DIABETIC NEPHROPATHY |
JP6553618B2 (ja) | 2013-12-18 | 2019-07-31 | シーエスエル リミティド | 創傷を治療する方法 |
WO2015100246A1 (en) | 2013-12-24 | 2015-07-02 | Ossianix, Inc. | Baff selective binding compounds and related methods |
EP3133085A1 (en) * | 2014-04-17 | 2017-02-22 | Teraclón Idf, S.L. | Vnar recombinant monoclonal antibodies that neutralize vascular endophelial growth factor vegf |
JP6454981B2 (ja) * | 2014-04-24 | 2019-01-23 | 住友電気工業株式会社 | 半導体積層体および受光素子 |
JP6355020B2 (ja) * | 2014-05-14 | 2018-07-11 | パナソニックIpマネジメント株式会社 | 目元用美容装置 |
EP3160995A2 (en) | 2014-06-26 | 2017-05-03 | Ossianix Inc. | Semi-synthetic nurse shark vnar libraries for making and using selective binding compounds |
CA2963692A1 (en) | 2014-10-09 | 2016-04-14 | Engmab Ag | Bispecific antibodies against cd3epsilon and ror1 |
KR20240045370A (ko) | 2014-10-23 | 2024-04-05 | 퀴아젠 사이언시스, 엘엘씨 | 펩티드 조성물 및 그의 용도 |
EP3209697A4 (en) | 2014-10-23 | 2018-05-30 | La Trobe University | Fn14-binding proteins and uses thereof |
CA2967830A1 (en) | 2014-11-14 | 2016-05-19 | Ossianix, Inc. | Tfr selective binding compounds and related methods |
AU2015367224B2 (en) | 2014-12-19 | 2020-12-10 | Monash University | IL-21 antibodies |
JP6863897B2 (ja) | 2015-01-09 | 2021-04-21 | アダルタ・リミテッド | Cxcr4結合分子 |
EP3302457A2 (en) | 2015-06-08 | 2018-04-11 | Lophius Biosciences GmbH | Composition for determination of cell-mediated immune responsiveness |
EA036975B1 (ru) | 2015-08-03 | 2021-01-21 | Энгмаб Сарл | Моноклональные антитела против bcma |
EP3816294A1 (en) | 2015-09-11 | 2021-05-05 | Biosceptre (UK) Limited | Chimeric antigen receptors and uses thereof |
US10273196B2 (en) | 2015-09-25 | 2019-04-30 | Exxonmobil Chemical Patents Inc. | Hydrocarbon dehydrocyclization |
AU2017259876A1 (en) | 2016-05-02 | 2018-10-25 | Ablynx Nv | Treatment of RSV infection |
AU2017331739A1 (en) | 2016-09-23 | 2019-03-07 | Csl Limited | Coagulation factor binding proteins and uses thereof |
EP4295918A3 (en) | 2016-11-02 | 2024-03-20 | Bristol-Myers Squibb Company | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
CN110325547B (zh) | 2016-11-07 | 2023-12-26 | 德格克斯有限公司 | 新淀粉样蛋白β寡聚体特异性结合分子 |
US11155612B2 (en) | 2017-04-21 | 2021-10-26 | Centro De Investigación Científica Y De Educación Superior De Ensenada, Baja California | vNAR antibody which binds VEGF for use in dogs or cats |
NZ760841A (en) | 2017-07-11 | 2024-02-23 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
CA3075367A1 (en) | 2017-09-27 | 2019-04-04 | Elasmogen Ltd | Specific binding molecules |
US20200354452A1 (en) | 2017-09-29 | 2020-11-12 | City Of Hope | Cars and bispecific antibodies for treatment of mantle cell lymphoma |
US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
US11180544B2 (en) * | 2017-11-07 | 2021-11-23 | City University Of Hong Kong | Method of producing antibody fragment |
US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
AU2018377856A1 (en) | 2017-11-29 | 2020-05-21 | Csl Limited | Method of treating or preventing ischemia-reperfusion injury |
CN112867503A (zh) | 2018-08-24 | 2021-05-28 | 希望之城 | 掩蔽的细胞因子缀合物 |
EP3877399A4 (en) | 2018-11-06 | 2022-10-19 | Alsatech, Inc. | CELL-BASED GENE THERAPY FOR NEURODEGENERATIVE DISEASES |
CA3119161A1 (en) | 2018-11-13 | 2020-05-22 | Compass Therapeutics Llc | Multispecific binding constructs against checkpoint molecules and uses thereof |
WO2022035998A1 (en) | 2020-08-11 | 2022-02-17 | City Of Hope | Compositions and uses of sars-cov-2 targeted chimeric antigen receptor modified nk cells |
GB202020152D0 (en) | 2020-12-18 | 2021-02-03 | Elasmogen Ltd | Fast-track humanisation of specific binding molecules |
WO2023092177A1 (en) * | 2021-11-23 | 2023-06-01 | Adalta Limited | Rank-l binding molecules |
WO2024008904A2 (en) | 2022-07-08 | 2024-01-11 | Novo Nordisk A/S | Highly potent isvd compounds capable of substituting for fviii(a) |
CN116284423B (zh) * | 2022-12-29 | 2023-10-03 | 江苏百英生物科技有限公司 | 一种靶向条纹斑竹鲨IgNAR-CH1多克隆抗体、其制备方法及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
JP2919890B2 (ja) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用 |
GB8927230D0 (en) | 1989-12-01 | 1990-01-31 | Unilever Plc | Reagents |
US5955363A (en) | 1990-01-03 | 1999-09-21 | Promega Corporation | Vector for in vitro mutagenesis and use thereof |
ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
EP1295952A3 (en) | 1996-01-23 | 2003-07-09 | The Board of Trustees of The Leland Stanford Junior University | Methods for screening for transdominant effector peptides and RNA molecules |
AUPP221098A0 (en) * | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
AU747637B2 (en) * | 1998-03-06 | 2002-05-16 | Arana Therapeutics (Vic) Pty Ltd | V-like domain binding molecules |
JP2004526419A (ja) * | 2000-10-16 | 2004-09-02 | フィロス インク. | 抗体模倣物および他の結合タンパク質のためのタンパク質骨格 |
EP1419179B1 (en) * | 2001-08-10 | 2010-03-03 | Aberdeen University | Antigen binding domains from fish |
ATE290020T1 (de) * | 2001-08-31 | 2005-03-15 | Avidex Ltd | Löslicher t zell rezeptor |
AU2002351896A1 (en) | 2001-12-11 | 2003-06-23 | Ablynx N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
US20040266993A1 (en) * | 2003-06-30 | 2004-12-30 | Evans Glen A. | Non-immunoglobulin binding polypeptides |
-
2005
- 2005-06-02 US US11/628,475 patent/US7977071B2/en active Active
- 2005-06-02 CA CA2567655A patent/CA2567655C/en active Active
- 2005-06-02 DK DK10179638.1T patent/DK2330121T3/en active
- 2005-06-02 EP EP10179611A patent/EP2330120A3/en not_active Withdrawn
- 2005-06-02 EP EP10179638.1A patent/EP2330121B1/en active Active
- 2005-06-02 WO PCT/AU2005/000789 patent/WO2005118629A1/en active Application Filing
- 2005-06-02 DK DK05744734.4T patent/DK1751181T3/da active
- 2005-06-02 EP EP05744734A patent/EP1751181B1/en active Active
- 2005-06-02 JP JP2007513617A patent/JP2008511286A/ja active Pending
- 2005-06-02 AU AU2005250055A patent/AU2005250055B2/en active Active
-
2008
- 2008-09-29 AU AU2008229687A patent/AU2008229687B2/en active Active
-
2009
- 2009-04-28 AU AU2009201692A patent/AU2009201692B2/en active Active
-
2011
- 2011-06-09 US US13/157,205 patent/US20120003214A1/en not_active Abandoned
- 2011-06-10 JP JP2011130413A patent/JP5631812B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-16 US US15/044,731 patent/US20160237169A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2330120A3 (en) | 2011-11-16 |
US20160237169A1 (en) | 2016-08-18 |
EP2330121A2 (en) | 2011-06-08 |
AU2008229687B2 (en) | 2009-01-29 |
CA2567655A1 (en) | 2005-12-15 |
AU2008229687A1 (en) | 2008-10-30 |
DK2330121T3 (en) | 2014-12-15 |
WO2005118629A1 (en) | 2005-12-15 |
AU2009201692A1 (en) | 2009-05-21 |
AU2005250055B2 (en) | 2008-09-11 |
EP2330120A2 (en) | 2011-06-08 |
EP1751181A4 (en) | 2008-03-12 |
US7977071B2 (en) | 2011-07-12 |
EP1751181A1 (en) | 2007-02-14 |
EP2330121B1 (en) | 2014-09-03 |
JP2008511286A (ja) | 2008-04-17 |
AU2009201692B2 (en) | 2012-08-30 |
EP1751181B1 (en) | 2012-08-15 |
DK1751181T3 (da) | 2012-11-26 |
US20120003214A1 (en) | 2012-01-05 |
US20090148438A1 (en) | 2009-06-11 |
EP2330121A3 (en) | 2011-11-16 |
AU2005250055A1 (en) | 2005-12-15 |
JP5631812B2 (ja) | 2014-11-26 |
JP2011244822A (ja) | 2011-12-08 |
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Legal Events
Date | Code | Title | Description |
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EEER | Examination request |