AU8871198A - Crystal of sm3 antibody (fragment) and recognizing epitope, its preparation, encoded data storage medium containing its coordinates and its diagnostical or medical use - Google Patents

Description

WO99/10379 PCT/GB98/02542 CRYSTAL OF SM3 ANTIBODY (FRAGMENT) AND RECOGNIZING EPITOPE, ITS PREPARATION, ENCODED DATA STORAGE MEDIUM CONTAINING ITS COORDINATES AND ITS DIAGNOSTICAL OR MEDICAL USE The present invention relates to a process for preparing a crystal, to the use of structural coordinates 5 of a crystal comprising the epitope binding fragment of an antibody bound to a peptide, to mimics of the antibody and peptide, to products recognisable by mimics of the antibody or which recognise mimics of the peptide, to engineered antibodies and to their use in diagnosis or 10 therapy. Introduction The monoclonal antibody SM3 (secreted by the 15 hybridoma HSM3 deposited with ECACC on 7 January 1987 under accession no. 87010701) binds to a tumour associated epitope on the epithelial mucin MUCl (WO-A 88/05054, WO 90/05142). The MUC1 epithelial mucin is a transmembrane 20 glycoprotein with the extracellular domain made up largely of exact tandem repeats of 20 amino acids, each of which contains five potential glycosylation sites (Gendler et al. 1988, 1990; see Figure 1). In breast and other carcinomas MUCl is over-expressed and is aberrantly 25 glycosylated making it antigenically distinct from the normally processed mucin. In breast cancers, the O glycans which are added are shorter (Hanish et al., 1989; Hull et al., 1989; Lloyd et al., 1996), resulting in the exposure of epitopes which are normally masked on the 30 core protein (Burchell and Taylor-Papadimitriou, 1993). Such epitopes are called cryptic epitopes. The SM3 antibody was raised against MUCl stripped of its carbohydrate (Burchell et al., 1987). SM3 recognises such a cryptic epitope, and shows high selectivity in 35 reacting specifically with the carcinoma associated mucin WO99/10379 PCT/GB98/02542 -2 in more than 90% of breast carcinomas (Girling et al., 1989). The high specificity of the SM3 antibody makes it a potentially useful tool in the diagnosis and treatment of breast cancer (Granowska et al., 1996). 5 The sequence of the repeating unit of the core protein of MUCl contains doublets of threonine and serine, bounding a highly immunogenic domain (Burchell et al., 1989; see Figure 1). A three-dimensional NMR structure for three multiple MUCI peptide repeats reveals 10 repeating "knob-like" structures, corresponding to the immunogenic domains which are connected by extended spacers (Fontenot et al., 1995). The epitope for SM3 has been mapped using overlapping peptides and found to correspond to just five contiguous amino acids, Pro-Asp 15 Thr-Arg-Pro (Burchell et al., 1989, hereafter referred to as the MUCI epitope) lying within the "knob-like" domain and between the potential serine and threonine glycosylation sites. In vitro studies using recombinant GalNAc transferase which adds the first sugar to Ser or 20 Thr suggest that Thr 1 Ser 12 and Thr 13 are glycosylated, while Thr 6 (within the MUC1 epitope) and Ser 2 are not (Wandall et al., 1997). The inventors have crystallised a fragment of SM3 bound to a peptide, subjected the crystal to X-ray 25 diffraction studies and measured the structure factors. From the structure factors they have solved the structural coordinates. These may be used to generate new diagnostic and therapeutic materials and for other investigative purposes. 30 The invention includes the use of the structure factors and/or structural coordinates to identify, characterise, design or screen chemical entities, which have uses in diagnosis and therapy, as will be discussed below. 35 In one aspect the present invention provides the WO99/10379 PCT/GB98/02542 -3 use of the structure factors and/or structural coordinates obtainable by subjecting a crystal comprising at least the epitope binding fragment of the SM3 antibody, bound to a peptide recognised by the epitope 5 binding site of SM3 to X-ray diffraction measurements and optionally thereafter analysing the diffraction measurements to deduce structural coordinates. The invention particularly provides a use of the structural coordinates of a moiety which comprises at 10 least the epitope binding fragment of the SM3 antibody or a substantially similar fragment bound to a peptide such as the crystal peptide. The moiety may be whole SM3 antibody, or a Fab fragment derived from the digestion of whole SM3 antibody by papain. The moiety may comprise a 15 modified form of whole SM3 or a modified form of a fragment of SM3. Such modifications include the insertion or deletion of amino acids, or replacement of amino acids by other amino acids. Other chemical modifications may be made. 20 The peptide may comprise the sequence Pro-Asp-Thr Arg-Pro, or any longer portion of the MUCl tandem repeat, for instance the sequence Thr-Ser-Ala-Pro-Asp-Thr-Arg Pro-Ala-Pro-Gly-Ser-Thr. The invention provides the use of the structure 25 factors and/or structural coordinates of a crystal of the Fab fragment of SM3 bound to the crystal peptide. The structure factors of such a crystal obtained as in the Examples are shown in Table 1 and the structural coordinates are shown in Tables 2a and 2b. The 30 structural coordinates shown in each of Tables 2a and 2b are derived from the structure factors. However the coordinates shown in Table 2b have been calculated to a higher refinement and include additional protein atoms. The invention provides the use of the structural 35 coordinates shown in Table 2a and/or Table 2b.

WO99/10379 PCT/GB98/02542 -4 The structural coordinates indicate the positions of individual atoms within the crystal and indicate the B factor for each atom which gives some information about the mobility of the atoms. The structure factors may be 5 used to derive additional information about the mobility of any individual atom or group of atoms within the crystal. This additional information, for instance, anisotropic B factors, may concern the direction of movement possible for each atom. The structure factors 10 and structural coordinates thus give an indication of the available space for adjusting the position of individual atoms when designing mimics of the peptide or antibody. Mimics of SM3 15 The invention provides the use of structure factors and/or structural coordinates to identify, characterise, design or screen mimics of SM3. The structural coordinates allow the epitope binding site bound to the peptide to be shown as a two dimensional representation, 20 for example as in the LIGPLOTs of Figures 8 to 11 or a three dimensional representation by physical models or as displayed on a computer screen. Such representation can be used to design modifications of SM3. Such modifications includes modifications to increase the 25 avidity of the epitope binding site for the bound peptide. This modification may preferentially increase the avidity of the epitope binding site for abnormally glycosylated MUC1. The avidity may be increased by modifying the 30 epitope binding site structure to increase the amount and number of interactions favourable to peptide binding and/or diminish unfavourable interactions between the peptide and antibody. Favourable interactions may be increased by extending the structure of the epitope 35 binding site into spaces which are shown in the two WO99/10379 PCT/GB98/02542 dimensional or three dimensional representations to be unoccupied or filled with water molecules. Such water molecules may include those which are shown in Figures 8 to 11. 5 The representations of the structures may be used in other ways to modify the structure of SM3. It is believed that SM3 may bind the peptide by an "induced fit" method which requires that conformation changes occur in the structure of SM3 during the process of 10 binding the peptide. The SM3 binding site, or other parts of SM3 may be modified to allow such changes to occur more easily. Alternatively the mimic of SM3 may comprise the SM3 epitope binding site constrained in the conformation it adopts when it binds the peptide. The 15 representations of the epitope binding site may be used to model such constraints by the putative introduction of covalent bonds between the atoms of SM3 which come close together when SM3 binds the peptide; one or more chemical linkers may be used between atoms of SM3 to constrain the 20 epitope binding site to the required conformation, and/or one or more amino acids of SM3 may be replaced by analogues of the natural amino acids which help to constrain the conformation of the epitope binding site. On the basis of such modelling SM3 mimics may be 25 identified, characterised, designed or screened. It is believed that the reason why SM3 has a low avidity for aberrantly glycosylated MUCl is steric hindrance between residues close to or in the epitope binding site and carbohydrate moieties attached to 30 positions 1, 12 and 13 of the peptide as shown in Figure 1. The representation of the epitope binding site bound to the peptide may be used to predict which residues of SM3 are likely to be involved in the steric hindrance. One such residue may be Proline 56 of SM3. Such residues 35 may be modified, replaced or deleted to decrease the WO99/10379 PCT/GB98/02542 -6 steric hindrance in order to increase avidity. Mimics of SM3 may for instance be obtained by computer modelling techniques. Using the structural coordinates a three dimensional representation of the 5 surface of the epitope binding site bound to the peptide can be produced using Catalyst Software such as Catalyst/SHAPE, Catalyst/COMPARE, DBServer HipHop Ludi, MCSS and Hook which are available from Molecular Simulations Ltd., 240/250 The Quorum, Barnwell Road, 10 Cambridge, England. Mimics of SM3 can be produced either by computationally identifying compounds which have a similar surface to the binding site of SM3, or by computationally designing compounds with surfaces which are likely to bind the peptide. Various methods can then 15 be used to produce a three dimensional surface which is the same or similar to the epitope binding surface. Based on this shape, packages such as Catalyst/SHAPE and Catalyst/COMPARE can be used to select compounds from databases which have a similar three dimensional shape to 20 the epitope binding site. The epitope binding site surface may be described in more detail by analysis of the functional groups present to produce a pharmacophore. Based on a pharmacophore, packages such as DBServerl and HipHop can be used to search databases for compounds 25 whose surfaces are described by similar pharmacophores. The databases that can be searched include ACD, NCI, Maybridge, Derwent World Index and BioByte. Packages such as Ludi and MCSS can be used to select fragments or chemical entities from databases 30 which can then be positioned in a variety of orientations, or "docked" with the surface of the peptide. Once suitable chemical entities or fragments which bind sites on the surface of the peptide have been identified bridging fragments and framework structure are 35 chosen with the correct size and geometry to support the WO99/10379 PCT/GB98/02542 -7 chemical entities and fragments in the favourable orientation and location and to form the mimic of SM3. Packages such as Hook can be used to select framework structures. 5 Once a candidate mimic of SM3 has been designed or selected by the above methods, the efficiency with which that mimic may bind to the peptide may be tested and optimized using computational or experimental evaluation. Various parameters can be optimized depending on the 10 desired result. These include, but are not limited to, specificity, avidity, on/off rates, and other characteristics readily identifiable by the skilled artisan. The computational means may employ packages such as 15 Catalyst/SHAPE, Catalyst/COMPARE, DBServer, HipHop, Ludi and MCSS to evaluate selected candidate SM3 mimics. The experimental means may comprise ELISA methods such as detailed below using GST-MUC1 ELISA plates or the techniques described in Bynum et al. 20 Thus, one may optionally make substitutions, deletions, or insertions in some of the components of the SM3 mimics in order to improve or modify the binding properties. Generally, initial substitutions are conservative, i.e. the replacement group will have 25 approximately the same size, shape, hydrophobicity and charge as the original component. Such modified mimics can be computationally or experimentally evaluated in the same manner as the first candidate SM3 mimics, and if necessary further modifications can be made. This process 30 of evaluating and modifying may be iterated any number of times. The term aberrantly glycosylated MUC1 is used throughout this specification to refer to MUC1 which has a different level of glycosylation than is normally found 35 on MUC1 from a particular tissue. The different level of WO99/10379 PCT/GB98/02542 -8 glycosylation may be a decrease in the level of glycosylation. MUCl with such decreased levels of glycosylation may be produced by a tumour cell, such as an adenocarcinoma cell for instance a cell from an 5 epithelial tumour of colon, lung, ovary, pancreas or especially a breast tumour cell. Mimics of SM3 preferably have a high avidity for aberrantly glycosylated MUC1. Such an avidity may be higher than that of SM3. They may have a higher 10 selectivity towards aberrantly glycosylated MUCl in preference to normally glycosylated MUCI than SM3. The avidity of the mimic of SM3 to bind aberrantly glycosylated MUCI can be tested in an ELISA assay as detailed below: 15 GST-Muc-1 ELISA Method Preparation of GST-Muc-1 Batch 5 ELISA plate. DNA coding for the seven tandem repeats of the 20 amino acid peptide epitope was cloned into a GST fusion vector, pGEX-2T (Pharmacia) in the E.Coli strain TG1 . The cells 20 were grown in L broth (100mg/ml ampicillin) overnight and then IPTG was added to a final concentration of 0.5 mM followed by a further incubation of 4 hr at 37 C The cells were pelleted (20min/O10000rpm), washed x2 with PBSa and resuspended in 25mM TRIS pH 8, 25mM Glucose, 10 mM 25 EDTA containing lyzozyme (4mg/ml) and left for 30 min at RT. 5ml of lysis buffer was then added and incubated on ice for 5 min. After centrifugation the supernatant was loaded onto a Glutathione Sepharose 4B column (Pharmacia) equilibrated in lysis buffer. The fusion protein product 30 was eluted in PBSa/15mM Glutathione and stored at 4 C until required. SDS-PAGE and FPLC Superose 6 (Pharmacia) size separation showed a single species mwt 43 K. Preparation of GST-Muc-I Batch 5 ELISA Plates 35 The GST-Muc-1 was diluted in PBSa to 50mg/ml and 50ml WO99/10379 PCT/GB98/02542 -9 added to each well of a 96 well plate The plates were incubated overnight at 4 C, blocked with 200ml 2% BSA/PBSa for 2 hr at RT. and stored at -70 C until required. 5 REAGENTS/BUFFERS Alkaline Phosphatase -Goat anti-mouse (Fc Specific) Sigma No. A-2429 10 BSA - Albumin Bovine, Fraction V powder, RIA grade, Sigma No A-7888 ELISA Plates - Nunc-Immuno Plates No. 442404 15 ELISA Substrate Buffer - Diethanolamine buffer pH 9-8 400ml Diethanolamine (Sigma D-2286) 24.5 mg MgCl2 BHD (Anala R) pH 9.8 with HCl and make up to 500ml with 20 distilled water EDTA Ethylenediamine tetra acetic acid BDH Anala R Glutathione Reduced ICN 101814 25 IPTG Isopropylthio-b-D-galactoside Promega Lysis Buffer 150mM NaCl, 16 mM Na2HPO4, 4mM NaH2PO4, 100mM EDTA, 1% Triton X (BDH Anala R) 30 2 mM PMSF (Phenylmethylsulfonyl fluoride) (Sigma) pNPP - p-Nitrophenyl Phosphate Sigma No. N-9389 PBSAa- Phosphate Buffered Saline (ICRF) 35 TWEEN 20 - Polyoxyethylene (20) Sorbitan monolaurate WO99/10379 PCT/GB98/02542 -10 BDH 66368 GST-Muc-l (a Glutathione-S-transferase fusion protein containing seven copies of the 20 amino acid 5 tandem repeat (non-glycosylated) ELISA plates are stored @ -70 0 C pre blocked with 2% BSA/PBSA.

(PBSA

Phosphate Buffered Saline BSA- Bovine Serum Albumin, Fraction V powder, RIA grade, Sigma No. A-7888.) 10 1. Thaw out a plate at room temperature (RT). 2. Test antibody samples are diluted in PBSA/ 0.02% Tween 20 (PBSA/T). e.g. SM3 from 100-0.001 mg/ml. 3. Wash the plate three times with PBSA/T. Add samples in a volume of 50 ml, in triplicate and leave at 15 RT for 1 hour. 4. Remove the antibody samples carefully by aspiration and add 200 ml of PBSA/T to each well. Remove by aspiration and repeat. Then wash again twice with PBSA/T. 20 5. Add 50 ml of 1/2000 (diluted PBSA/T) Goat anti-mouse (Fc Specific) Alkaline Phosphatase (Sigma No. A-24209) to each well and incubate at RT. for 1 hour. 6. Wash the plate three times with PBSA/T and then add 50ml of substrate which is p-Dinitrophenyl 25 Phosphate (Sigma N-2765) at lmg/ml in Diethanolamine Buffer pH 9.8, (400ml distilled water, 48ml diethanolamine, 24.5mg MgCl 2 , pH 9.8 with HCI and make up to 500ml with distilled water). 7. Incubate at RT. for 15 min and read the OD at 30 405 nm on the Labsystems Multiscan Plate reader. The avidity of the mimic of SM3 can also be measured using methods described in Bynum et al. These techniques may also be used to test the specificity of the mimic of SM3 by testing the avidity of 35 the mimic for aberrantly glycosylated MUC1 and for WO99/10379 PCT/GB98/02542 -11 normally glycosylation MUC1. A histological screen using the mimic of SM3 can be performed using tumour tissue from a breast tumour and normal tissue, for example, as described in Girling et 5 al., 1989. This can be used to determine if the mimic is specific for the aberrantly glycosylated MUC1 and therefore suitable for use in a method of diagnosing breast cancer. The mimic can also be tested against live tumour cells which are not fixed. 10 Cells which have MUC1 with reduced levels of glycosylation can be produced by the use of metabolic inhibitors of O-linked chain extension, such as O benzylgalactosamine. Such cells can be used to study the effects of low levels of glycosylation of MUC1 on the 15 avidity of the mimics of SM3. Mimics of SM3 may be used in a diagnostic test to detect the presence of tumour cells in a tissue sample, for example in a histological screening. Mimics used in this manner may be labelled with a detectable label. 20 Alternatively agents able to specifically bind such mimics may be used to detect the presence of the mimics once the mimics have bound the aberrantly glycosylated. The mimics of SM3 may be used in vivo for the detection of tumour cells. They may be used in tumour 25 imaging in vivo. Generally, such mimics would be labelled with a detectable label. The mimics of SM3 can be used in a method of therapy against cancer, particularly adenocarcinomas such as ovary, colon, lung, pancreas and breast epithelial 30 cancers, especially breast cancers. Mimics which are antibodies or substantially similar to antibodies or fragments of antibodies may bind to aberrantly glycosylated MUC1 on the surface of tumour cells and aid the killing of the tumour cells by 35 recruiting the patients immune system.

WO99/10379 PCT/GB98/02542 -12 Mimics of SM3 may be chemically linked to a cytotoxic agents such as a toxin or a radioisotope. Binding of such toxin linked mimics to the tumour cells would lead to the killing of the tumour cell. 5 It is believed that high levels of MUC1 or aberrantly glycosylated forms of MUCl may have an immunosuppressive effect. Tumour cells may have high levels of MUCl on their surface and/or aberrantly glycosylated forms. Therefore in the method of therapy of 10 the invention a mimic of SM3 could be used to bind to MUC1 in vivo and prevent or decrease its immunosuppressive effects. The types of immunosuppressive effects that may be prevented or decreased are discussed below in relation to mimics of the MUCI epitope. Such a 15 mimic could be administered in conjunction with an anti tumour agent, such as an anti-tumour vaccine, and may have an adjuvant-like effect (the mimic may increase the immune response generated by the vaccine). The anti tumour agent could be a mimic of the SM3 epitope. The 20 mimic of SM3 could be administered at any time in relation to the administration of the anti-tumour agent, for example before, with or after the administration of the anti-tumour agent. Thus the invention provides a mimic of SM3 for use 25 in a method for treatment of the human or animal body by surgery or therapy or in a diagnostic method practised on the human or animal body, such as in anti-cancer therapy. The invention also provides a product comprising a mimic of SM3 and an anti-tumour agent as a combined preparation 30 for simultaneous, separate or sequential use in anti cancer therapy. The invention provides a use of a mimic of SM3 in the production of a pharmaceutical composition for use in the methods discussed above. The invention provides a 35 pharmaceutical composition containing a mimic of SM3 and WO99/10379 PCT/GB98/02542 -13 a diluent or carrier. The invention provides a method of treating or diagnosing cancer by administering to a human or non-human animal in need thereof an effective non toxic amount of a mimic of SM3. 5 The production of mimics of SM3 and the methods, routes and dosages for use of the mimics of SM3 are discussed below. Mimics of MUCl epitome peptides The invention allows the use of the structure 10 factors and the structural coordinates to identify, characterise or design a mimic of the MUCl epitope peptides. Such a mimic may be used to produce a specific binding agent which has a desired association with aberrantly glycosylated MUC1. The mimic of the peptide 15 can be used to select a specific binding agent from a library on the basis of its affinity to the mimic. Such a library may be a microbial display library, such as a phage display library. The specific binding agent may bind aberrantly glycosylated MUC1, and therefore be used 20 in a similar manner to the mimics of SM3. The mimic of the peptide may be used in a vaccine administered to a human or animal. Such a vaccine would stimulate the production of antibodies able to bind aberrantly glycosylated MUC1. Such a vaccine could therefore be 25 used as a therapy against cancer, for example to prevent or treat cancer. Thus the invention provides a mimic of the MUCl epitope, a mimic of the MUC1 epitope for use a method for treatment of the human or animal body by surgery or 30 therapy or in a diagnostic method practised on the human or animal body, such as in anti-cancer therapy. The invention also provides a use of such a mimic in the production of a pharmaceutical composition for use in such a method. The invention provides a pharmaceutical 35 composition containing a mimic of the MUC1 epitope and a WO99/10379 PCT/GB98/02542 -14 diluent or carrier therefor. The invention provides a method of diagnosing or treating cancer by administrating an effective non-toxic amount of a mimic of the MUCI epitope to a human or non-human animal in need thereof. 5 The production of mimics of the MUCI epitope and methods, routes and dosages for use of the mimics of the MUCi epitope are discussed below. The MUC1 epitope mimics may also be administered to an animal preferably a laboratory mammal, such as a 10 rodent, for instance a mouse, in order to induce an antibody response. Antibody secreting cells may be recovered from the animal and hybridoma technology may then be used to produce a hybridoma using such recovered cells. The hybridoma or any other antibody expression 15 system would be a source of monoclonal antibodies capable of recognising the mimic and preferably the MUC1 epitope and thus have diagnostic and therapeutic utilities as for the SM3 mimics described above. As described above it is believed that MUCI may 20 cause immunosuppressive effects. Thus the mimic of the epitope may be capable of causing an immunosuppressive effect, and thus may be used to cause such an effect in a human or animal. The immunosuppressive effect may be caused by the mimic decreasing the activity of T cells, 25 such as CD4 or CD8 T cells. The T cells may be polyclonal. The mimic may cause a decrease in (i)the proliferation of the T cells, (ii) their secretion of cytokines,(iii) their interaction with other cells, such 30 as interaction mediated by ICAM-1 on the T cell surface, and/or(iv)their cytotoxic activity. The mimic may cause the cross-linking of a surface molecule on the T cells, such as ICAM-1. The mimic may cause T cells to become anergic. The effects of the mimic may be reversible by 35 the addition of IL-2 or anti-CD28 antibody.

WO99/10379 PCT/GB98/02542 -15 Thus the mimic may be used to decrease or prevent an immune response, particularly when the response has a deleterious effect on the body. Thus the mimic may be used in the therapy (i.e. to treat or prevent) of 5 diseases caused by autoimmune responses (such as arthritis, multiple sclerosis, asthma or diabetes), allergies, inflammatory disorders or transplant rejections, such as graft versus host disease. Thus the invention provides a mimic of the MUCI 10 epitope for use in therapy which prevents or decreases an immune response, and so can treat or prevent a disease caused by an immune response. The invention also provides a use of such a mimic in the production of a pharmaceutical composition for use in such a method. The 15 invention provides a method of treating a disease caused by an immune response, such as autoimmune disease, allergy, inflammatory disorder or transplant rejection; by administrating an effective non-toxic amount of a mimic of the MUCl epitope to a human or non-human animal 20 in need thereof. As with the mimics of SM3 the two dimensional and three dimensional representations of the epitope binding site bound to the peptide mentioned previously can be used to design a mimic which is, for instance, a peptide 25 or a derivative thereof or an analogue of a peptide comprising the sequence Pro-Asp-Thr-Arg-Pro or the sequence Thr-Ser-Ala-Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-Ser constrained in the conformation approximately that which the crystal peptide adopts when bound to SM3. 30 The sequence can be constrained by the introduction of covalent bonds between atoms which come close together in the conformation adopted when bound to SM3. Alternatively a chemical linker may be used to join such atoms together. The sequences may be constrained by 35 cyclisation of a peptide in which the relevant sequence WO99/10379 PCT/GB98/02542 -16 is present. The peptides may also be constrained by replacement of one or more amino acids by analogues of natural amino acids which cause the peptide analogue to adopt the required conformation when they are introduced. 5 Hydrogen bonds, such as intra-peptide hydrogen bonds may be introduced into the mimic. These may help to constrain the mimic to a particular conformation, such as the conformation adopted when bound to SM3. The structural coordinates allow the epitope 10 binding site bound to the crystal peptide to be shown as a two dimensional representation, for example the LIGPLOTs of Figures 8 to 11 or a three dimensional representation on a computer screen. Such representation can be used to design modifications to the MUC1 epitope 15 which may increase its avidity for SM3, for example, by increasing the "on rate" relative to the crystal peptide and decreasing the "off rate". The avidity of the MUCl epitope mimic for the epitope binding site may be increased using a similar strategy as used to design 20 mimics of SM3. The mimic can be modified to increase the amount and number of favourable interactions with SM3, for example by extending the structure of the MUCI epitope into spaces which are shown to be unoccupied or filled with water molecules. Such water molecules may 25 include those shown in Figures 8 to 11. It is appreciated that such mimics of the MUC1 epitope which are designed to have an increased avidity with the epitope binding site of SM3 may not cause the production of antibodies with a higher avidity to aberrantly 30 glycosylated MUC1 than SM3 has, however such mimics may lead to the stimulation of an increased antibody response due to their higher avidity to the antibody. The two dimensional and three dimensional representation of the epitope binding site bound to the crystal peptide can as 35 mentioned previously be used to determine why SM3 binds WO99/10379 PCT/GB98/02542 -17 the peptide with a low avidity. This information can then be used to design mimics of the MUCI epitope which can select from a library those mimics of SM3 which have a high avidity to aberrantly glycosylated MUC1. Such 5 mimics, when administered in a vaccine may also stimulate the production of antibodies with a higher avidity to aberrantly glycosylated MUC1 than SM3. Such mimics of the MUC1 epitope may for example be designed by modifying the structure of the crystal 10 peptide which binds SM3 in those areas where unfavourable interactions occur between the crystal peptide and epitope binding site which cause a lowering of avidity. For example the structure of the MUC1 epitope may be extended in those areas where steric hinderance occurs 15 between the carbohydrates on the aberrantly glycosylated MUC1 and the epitope binding site. Use of such a mimic may lead to the selection of specific binding agents (as described above) from a library or the stimulation of antibodies which have a reduced level of steric 20 hinderance with the carbohydrate and therefore a higher avidity for aberrantly glycosylated MUC1. Mimics of the MUC1 epitope may be designed by computer modelling techniques in a similar manner to the designing of mimics of SM3 using these techniques. 25 Again, packages such as Catalyst/SHAPE and Catalyst/COMPARE can be used to select compounds with a similar three dimensional shape to the peptide when it is bound to SM3. Packages such as DBServer and HipHop can be used to find compounds with similar pharmacophores to 30 the peptide and packages such as Ludi, MCSS and Hook can be used to design a mimic which is predicted to bind well to the epitope binding site of SM3. Once a candidate mimic has been designed or selected by the above methods, the efficiency with which 35 that mimic may bind to the SM3 epitope binding site may WO99/10379 PCT/GB98/02542 -18 be tested and optimized using computational or experimental evaluation. As described previously packages such as Catalyst/SHAPE, Catalyst/COMPARE, DBServer, Ludi and MCSS may be used to computationally 5 evaluate the mimic. The mimic may be experimentally evaluated in the competition ELISA assay described below. Various parameters can be optimized depending on the desired result. These include, but are not limited to, specificity, avidity, on/off rates, and other 10 characteristics readily identifiable by the skilled artisan. Thus, one may optionally make substitutions, deletions, or insertions in some of the components of the MUC1 epitope in order to improve or modify the binding 15 properties. Generally, initial substitutions are conservative, i.e. the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original component. As with the mimic of SM3 the process of evaluation 20 and modification can be iterated any number of times. The mimic of the MUCl epitope may be glycosylated. The mimic may have an intra-peptide hydrogen bond. This may be between the residues equivalent to Pro 4 and Thr 6 of the MUC1 epitope or between the residues 25 equivalent to Asp 5 and Arg 7. The atoms involved in the hydrogen bond may be the equivalent of Pro 4 (atom O), Thr 6 (atom N), Asp 5 (atom OD1) and/or Arg 7 (atom N). The mimic of the MUC1 epitope may have higher avidity to SM3 than aberrantly glycosylated MUC1, or a 30 low avidity or may not bind at all. The avidity of the mimic can be tested in a competition ELISA assay in which a MUC1 peptide such as aberrantly glycosylated MUC1, deglycosylated MUC1 or the fully stripped core protein or a fragment thereof is attached to the plate and SM3 is 35 added in the presence of the mimic of the MUC1 epitope.

WO99/10379 PCT/GB98/02542 -19 By measuring the ability of the mimic to inhibit the binding of the antibody to the MUCl peptide the avidity of the mimic for SM3 can be measured. Preferred mimics include those which lead to the selection of specific 5 binding agents from a library which bind aberrantly glycosylated MUCl with a higher avidity and/or higher selectivity than SM3. Preferred mimics of the MUCl epitope are also those which stimulate the production of antibodies in vivo which have a higher affinity than SM3. 10 As discussed above specific binding agents include those which have been selected from a library, which may include antibodies, or those antibodies produced by B cells which bind the mimic of the peptide. Preferred specific binding agents are those which bind aberrantly 15 glycosylated MUCl with an avidity and/or specificity higher than SM3. The specific binding agents may be used in a diagnostic test to detect the presence of tumour cells in a tissue sample, for example in a histological screening. 20 Specific binding agents used in this manner may be labelled with a detectable label. Alternatively moieties able to specifically bind such mimics may be used to detect the presence of the specific binding agents once the specific binding agents have bound the aberrantly 25 glycosylated. The specific binding agents may be used in vivo for the detection of tumour cells. They may be used in tumour imaging in vivo. Generally, such specific binding agents would be labelled with a detectable label. 30 The specific binding agents may be used to prevent or decrease immunosuppression caused by MUC1. The specific binding agents can be used in a method of therapy against cancer, particularly breast cancer. Specific binding agents which are antibodies or 35 substantially similar to antibodies or fragments of WO99/10379 PCT/GB98/02542 -20 antibodies may bind to aberrantly glycosylated MUCI on the surface of tumour cells and aid the killing of the tumour cells by the immune system. Specific binding agents may be chemically linked to 5 a cytotoxic agents such as a toxin or a radioisotope. Binding of such toxin linked specific binding agents to the tumour cells would lead the killing of the tumour cell. Thus the invention provides a specific binding 10 agent for use a method for treatment of the human or animal body by surgery or therapy or in a diagnostic method practised on the human or animal body, such as in anti-cancer therapy. The invention also provides a use of a specific binding agent in the production of a 15 pharmaceutical composition for use in such a method. The invention provides a pharmaceutical composition containing a specific binding agent and a diluent or carrier therefor. The invention also provides a method of diagnosing or treating cancer by administering an 20 effective non-toxic amount of a specific binding agent to a human or non-human animal in need thereof. The invention also provides a product comprising a specific binding agent and an anti-tumour agent as a combined preparation for simultaneous, separate or 25 sequential use in anti-cancer therapy. The production of such specific binding agents and of the MUC1 epitope mimics and methods, routes and dosages for use of the agents and mimics are discussed below. 30 When administered to an animal or human the mimic of SM3 may lead to the production of antibodies which recognise the mimic. B cells from the animal or human may be used in conjunction with hybridoma technology to produce such antibodies as monoclonal antibodies. Such 35 antibodies may have a epitope binding site which is WO99/10379 PCT/GB98/02542 -21 similar in shape to the crystal peptide. The administration of such antibodies to an animal or human may lead to the production of antibodies which recognise aberrantly glycosylated MUC1. Therefore the antibodies 5 which recognise SM3 may be used as a vaccine or may be used to produce a vaccine against cancer. The antibodies or fragments thereof which recognise aberrantly glycosylated MUCl produced in response to the anti-mimic of SM3 antibody may themselves be used in an 10 anti-cancer treatment or in a diagnostic method. Thus the invention also provides such an antibody or fragment thereof for use in a method for treatment of the human or animal body by surgery or therapy or in a diagnostic method practised on the human or animal body, such as in 15 anti-cancer therapy. The invention also provides use of such an antibody or fragment thereof in the production of a pharmaceutical composition for use in such a method. The invention provides a pharmaceutical composition containing such an antibody or fragment thereof and a 20 diluent or carrier therefor. The invention also provides a method of diagnosing or treating cancer by administering an effective non-toxic amount of such an antibody or fragment thereof to a human or non-human animal in need thereof. 25 The invention provides the use of H3 chain of SM3 as a therapeutic or diagnostic agent. The invention also provides the use of HI chain of SM3 as a therapeutic or diagnostic agent. Thus the invention also provides such an H3 or HI chain for use in a method for treatment of 30 the human or animal body by surgery or therapy or in a diagnostic method practised on the human or animal body, such as in anti-cancer therapy. The invention also provides use of such an HI or H3 chain in the production of a pharmaceutical composition for use in such a method. 35 The invention provides a pharmaceutical composition WO99/10379 PCT/GB98/02542 -22 containing such an HI or H3 chain and a diluent or carrier therefor. The invention also provides a method of diagnosing or treating cancer by administering an effective non-toxic amount of such an HI or H3 chain to a 5 human or non-human animal in need thereof. The invention provides the use of the structure factors and/or structural coordinates to solve structural coordinates of other crystals. Such a crystal may comprise an antibody or antibody fragment. In particular 10 the structural coordinates can be used to solve the structural coordinates of a crystal comprising an antibody which has a non-proline cis peptide bond. The cis peptide bond may be in the H3 chain of the antibody. The invention provides the use of the structure 15 factors and/or structural coordinates to engineer, design or modify an antibody. The engineering may be for the purpose of humanising the antibody. The engineering may comprise the replacement of portions of the antibody. The portions of the antibody may be replaced with portions 20 from another protein, such as a human protein, for instance a human antibody. Two dimensional and three dimensional representations, such as those discussed previously, may be used during the engineering of the antibody to ensure that the epitope binding site of the 25 antibody is the same or substantially similar to the antibody binding site of SM3. The engineering of the antibody may be for the purpose of increasing the contribution made by the H3 and HI chains in the binding of the epitope. 30 The invention provides the use of an engineered glycine in a protein to insert a non-proline cis peptide bond into the protein. The insertion of the glycine may enable the protein to undergo conformational change, for instance in connection with a specific binding reaction 35 where the affinity, avidity or selectivity of the WO99/10379 PCT/GB98/02542 -23 specific binding reaction is modified by adoption of a cis peptide bond adjacent to the engineered glycine. The engineered glycine can be inserted using site directed mutation techniques, such as those described in Short 5 Protocols in Molecular Biology, 3rd edition, published by John Wiley and Sons, Inc., USA. The protein may be an antibody or fragment of a antibody. The engineered glycine may be in a CDR loop of the antibody. The insertion of the engineered glycine in an antibody will 10 generally affect the binding of the antibody to an epitope. The invention also provides a method of producing a crystal which comprises the use of cadmium. Generally the method comprises contacting any one of the moieties to be 15 crystallised with cadmium such as by use of a solution of a cadmium salt. The cadmium ions may be present in the solution in which the crystal is grown. In the case where the mimic of SM3, the mimic of the MUCI epitope or the specific binding agent comprise a 20 peptide then such agents may be delivered to animal or human by the admimistration of a nucleic acid which encodes such a peptide. Transcription and translation or merely translation of the nucleic acid would lead to the production of the peptide in vivo. It is appreciated by 25 the skilled artisan that the nucleic acid may be within a suitable vector, especially an expression vector, for instance a virus or an organism which is administered, such as a Vaccinia virus, for instance an attenuated Vaccinia virus or the nucleic acid may be administered in 30 the presence of a suitable diluent or carrier as in the use of "naked DNA". Nucleic acids encoding such peptides form a further aspect of the present invention as do their uses in cancer therapy and pharmaceutical compositions containing them. 35 Thus the invention also provides such nucleic acids WO99/10379 PCT/GB98/02542 -24 for use in a method for treatment of the human or animal body by surgery or therapy or in a diagnostic method practised on the human or animal body, such as in anti cancer therapy. The invention also provides use of such 5 nucleic acids in the production of a pharmaceutical composition for use in such a method. The invention provides a pharmaceutical composition containing such nucleic acids and a diluent or carrier therefor. The invention also provides a method of diagnosing or 10 treating cancer by administering an effective non-toxic amount of such nucleic acids to a human or non-human animal in need thereof. The mimic of SM3, mimics of the MUC1 epitope, selective binding agents, nucleic acids, viruses or 15 organisms containing nucleic acids of the invention (hereafter referred to as substances of the invention) may be formulated for clinical administration by mixing them with a pharmaceutically acceptable carrier or diluent. For example the substances can be formulated 20 for topical, parenteral, intravenous, intramuscular, subcutaneous, or transdermal administration. They may be mixed with any vehicle, e.g. a diluent or carrier which is pharmaceutically acceptable and appropriate for the desired route of administration. The pharmaceutical 25 carrier or diluent for injection may be, for example, a sterile or isotonic solution such as Water for Injection or physiological saline. The dose may be adjusted to deliver an effective non-toxic amount and according to various parameters, 30 especially according to the nature and efficacy of the substance used; the age, weight and condition of the patient to be treated; the mode of administration used; the conditions to be treated; and the required clinical regimen. As a guide, the amount of therapeutic substance 35 such as a polypeptide to be administered by injection WO99/10379 PCT/GB98/02542 -25 will generally be from 10 to 1000pg. For instance 100 to 500pg. For in vivo diagnostic imaging purposes in particular, the dose will depend on similar factors but may need to be much larger in order to generate an 5 appropriate image. The routes of administration and dosages described are intended only as a guide since a skilled practitioner will be able to determine readily the optimum route of administration and dosage for any particular patient and 10 condition. The substances of the invention may be produced by conventional techniques well known to those skilled in the relevant arts. Peptides may be synthesised de novo or produced by transcription and translation of DNA or 15 translation of RNA in a suitable expression system by conventional methods. Nucleic acids may be produced by de novo synthesis, obtained from natural sources such as by conventional probing and cloning techniques or generated from natural sources by modification by well 20 known methods. Antibodies may be made by suitable immunisation protocols and purified from immunised animals by conventional techniques, or they may be made by hybridomas and similar antibody secreting cell lines cultured in vitro or they may be obtained by expression 25 from suitable nucleic acids. Hybridomas and other antibody secreting cells may be obtained, cultured and used to produce antibodies by conventional methods. Chemical modification of such materials as peptides and antibodies may be achieved by well known methods. 30 Fragments of antibodies maybe produced by known chemical or enzymatic digestions or by expression from suitably modified nucleic acids. New chemical entities such as mimics of the MUC1 epitope may be produced by the well known techniques of synthetic organic chemistry. 35 The substance of the invention does not include WO99/10379 PCT/GB98/02542 -26 those peptides disclosed in WO-A-88/05054 or in WO-A 90/05142. The present invention is illustrated by the figures of the accompanying drawings which are described below: 5 Brief Description of the Drawings Figure 1 shows the amino acid sequence of the MUC1 tandem repeat. Figures 2 and 3 show experimental electron density 10 maps and the refined atomic models of the epitope binding site of SM3 and part of the crystal peptide. Figure 4 shows a comparison of the conformations of the unbound and bound peptide. Figures 5 and 6 show molecular surface features of 15 the SM3-crystal peptide interaction. Figure 7 is a stereo view of the non-proline cis peptide bond in CDR H3. Figures 8, 9, 10 and 11 are LIGPLOTs of the peptide binding site. 20 Figure 12 shows experimental density maps of the cis- peptide conformation in H3. Figure 13 shows a Ramachandran plot for the H3 fragment. Figure 14 shows the main chain temperature factors 25 of the fragment from H3. Figure 15 shows a stereo view of the MUCI peptide in the antibody combining site. Figure 16 shows a stereo view of the non-proline cis- peptide bond in H3. 30 Detailed Description of the Drawings Figure 1 shows MUC1 tandem repeat sequence written from N- to C-terminal using the Internationally recognised 3-letter code (which is used throughout this 35 specification). The epitope recognised by SM3 is shown in WO99/10379 PCT/GB98/02542 -27 bold (Pro-Asp-Thr-Arg-Pro) with the immunodominant region indicated by the double headed arrow. The probable glycosylation sites are shown in bold italics. The peptide used for the crystallisation studies (Thr-Ser 5 Ala-Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-Ser-Thr) is underlined (and is herein referred to as "the crystal peptide"). Figures 2 and 3 show experimental electron density maps and refined atomic models calculated using the 10 observed structure factors (30 to 1.95 A) and calculated phases after solvent modification. The maps are contoured at 1.0 o. Figure 2 shows part of the MUCl peptide antigen showing the immunodominant region. The numbering refers to Figure 1. Figure 3 shows the cis 15 peptide bond in CDR H3 between residues Gly96H and Gln97H. Two water molecules are shown forming hydrogen bonds to amide nitrogens. Figure 4 shows the unbound and bound peptide. The unbound peptide is shown on the left. The structure 20 represents the "knob-like" region and was determined in solution by NMR; it includes the whole of one tandem repeat and parts of the two flanking repeats (Fontenot et al., 1995). The conformation of the crystal peptide as bound by SM3 is shown on the right. There appears to be 25 a conformational transition of the "knob-like" region upon SM3 binding, which leads to a more extended peptide conformation. The main differences can be attributed to the + angles of Asp5P and Arg7P. Figure 5 shows a CPK model of the SM3 combining 30 site with the individual CDR loops labelled. The crystal peptide is shown contacting all of the CDR's except H2. Figure 6 shows electrostatic surface potential representation of the SM3 peptide complex. The surface was calculated using GRASP (Nicholls et al., 1991). The 35 crystal peptide is shown as a stick model.

WO99/10379 PCT/GB98/02542 -28 Figure 7 shows the cis-peptide bond in H3. The interactions between the residues Gly96H-Gln97 and the crystal peptide (solid) are shown. Hydrogen bonds are dotted (drawn using MOLSCRIPT; Kraulis, 1991). 5 Figures 8, 9, 10 and 11 are LIGPLOTS showing the main interactions which occur between the SM3 binding site, the crystal peptide and water molecules. KEY: 10 O . Ligand m/c His 53 Non-ligand residues involved in hydrophobic - Ligand sidechain contact(s) - w-- Hydrogen bond and its length '* Corresponding atoms involved in hydrophobic contact(s) 0 WAT = water 15 Figure 12 shows experimental electron density maps calculated using the observed structure factors (30 to 1.95 A and calculated phases after solvent modification, contoured at 1.0 o level (2Fo-Fc) and 2.0 a (Fo-Fc). Residue numbering as in the text. The model with this 20 cis- peptide bond is coloured according to atom type. (A) 2Fo-Fc difference density, calculated for the refined model with a trans Gly96H-Gln97H peptide bond. (B) 2Fo Fc and Fo-Fc (residual negative electron density; and positive density) map, calculated for the refined model 25 with a cis Gly96H-Gln97H peptide bond. (C) 2Fo-Fc difference electron density map around the final cis Gly96H-Gly97H fragment, showing the hydrogen bonds which appear to stabilise the cis - peptide conformation. Figure 13 shows a Ramachandran plot for the H3 30 fragment refined with cis and trans Gly96H-Gly97H peptide bond. Residues are labelled accordingly. Created by PROCHECK, Laskowski et al., 1993. Figure 14 shows the main chain temperature factors of the fragment from H3 which contains the non-proline 35 cis- peptide bond between Gly96H and Gln97H. Values for WO99/10379 PCT/GB98/02542 -29 the refined cis - confirmation are shown as open boxes (solid line), while those for the trans are indicated with closed circles (dashed line). Figure 15 shows a view of the MUCl peptide in the 5 antibody combining site. The peptide antigen is labelled and is shown in bold. SM3 Fab residues which interact with the peptide are labelled. Hydrogen bonds are shown as dotted lines with water molecules as black spheres. Drawn by MOLSCRIPT (Kraulis, 1991). 10 Figure 16 shows the cis peptide bond. The interactions between the residues GIy96H-Gln97H and part of the peptide antigen (bold) are shown. Hydrogen bonds are dotted and waters are represented as black spheres (drawn using MOLSCRIPT; Kraulis, 1991). The hydrogen 15 bond between Gly96H (N) and the peptide antigen, as mediated via a water molecule, is lost for a trans peptide conformation for Gly96H-Gln96H. The invention is further illustrated by the Examples: 20 Example 1 Assessment of the Binding of the MUC1 epitope to SM3. The sequence of the MUCI peptide in the context of the MUCl repeat is shown in Figure 1. The region of the 25 MUCI repeat for the co-crystallisation studies was chosen to keep the peptide as soluble as possible, while maintaining most of the tertiary structure of the knob region as based upon the NMR structure of the mucin repeats [Fontenot, J.D., Mariappan, S.V.S., Catasti, P., 30 Domenech, N., Finn, O.J. and Gupta, G.J. Biomol. Struct. and Dynam. 13, (1995) 245-260]. The binding of the MUCl epitope to SM3 was assessed by inhibition in an ELISA assay. The assay involved SM3 binding to a recombinant fusion protein containing seven copies of the MUC1 tandem 35 repeat, a lpg/ml concentration of SM3 was incubated with WO99/10379 PCT/GB98/02542 -30 increasing concentrations of peptide, a 50% inhibition was achieved at a peptide concentration of approximately 30pg/ml (Apparent Ka-24pM). In contrast a peptide of the same composition but different sequence (Ala-Arg-Pro-Thr 5 Gly-Thr-Ser-Asp-Pro-Thr-Pro-Ala-Ser) gave no detectable inhibition at the same concentration. Example 2 Preparation of the SM3 Fab fragments. SM3 at 4mg/ml in 100 mM sodium acetate pH 6.0, 3mM 10 EDTA, 50mM cysteine was incubated with 160 pg/ml of papain for 4 hr at 37 0 C. Fabs were purified by gel filtration on Superose 6 in PBS, followed by dialysis into 20mM Tris pH 8.0 and then Mono Q ion exchange chromatography. Fractions were analyzed by SDS PAGE and 15 Fab fractions concentrated to 4 mg/ml in 10mM Tris pH 8.0. The overall yield was 22%. Example 3 Crystallisation of the SM3 Fab fragment bound to the MUC1 epitope. 20 The SM3 Fab fragments were mixed with concentrated solution of the peptide at a molar ratio 1:5, incubated for 3 hours at 37'C, and then concentrated to 9.5 mg/ml. The crystallisation trials were conducted using the hanging drop method. A wide range of conditions were 25 tested using commercial screens, namely Hampton Research I and II [Jancarik, J. and Kim, S.H. J. Appl. Cryst. 24, (1991) 409-411 and Cudney, R., Patel, S., Weisgraber K., Newhouse, Y., and McPherson, A. Acta Cryst. D50, (1994) 414-423]. Although the initial screens did not give 30 crystals, they indicated that polyethylene glycol (PEG) was the most promising precipitant. In subsequent trials we varied the molecular weight of PEG, buffer pH range (4-9) and effect of salts. Finally, a shower of tiny needles appeared in the drops equilibrated against a 35 solution of PEG 4000 as a precipitant and acetate buffer, WO 99/10379 PCT/GB98/02542 -31 pH 5.0-7.0, with aggregated prisms appearing at higher pH, 6.5-7.5. However, all of these original crystals were too small for data collection. As seeding attempts were unsuccessful, we tried other ways to improve the 5 crystal morphology and size, including a metal ion screen. Addition of cadmium chloride gave larger crystals which were often twinned or aggregated. However, occasionally single crystals could be separated, one of which was used for data collection. The final 10 conditions were; 2.5pl of the antibody-antigen complex mixed with 2.5pl of the well solution containing 0.2 M CdCl 2 , 19% w/v of PEG 4000, and 0.1 M acetate buffer, pH 6.0. 15 Example 4 Diffraction measurements of the SM3 Fab fragment/MUC1 epitope crystal. A monocrystal of dimensions 0.4 x 0.2 x 0.03 mm was used for the diffraction measurements at the Xll outstation of the DESY synchrotron in Hamburg. Analysis 20 of the diffraction data showed that the crystal belongs to the monoclinic P2 1 space group with unit cell dimensions a=42.2, b=83.9, c=64.5 A, and f=93.4 0 . Assuming one complex molecule per asymmetric unit, the specific volume Vm=2.50 A3/Da of protein corresponds to a 25 solvent content of 51% (Matthews, 1968). Since the number of available crystals was limited, data collection was carried out at 110 K. The crystal was transferred to a glycerol-enriched mother liquor (10% of the water in mother liquor was substituted by glycerol) and then 30 flash-frozen using standard techniques (Teng, 1990) in a stream of nitrogen gas produced by an Oxford Cryosystem. A complete dataset up to 1.95 A resolution was collected using synchrotron radiation at wavelength 0.912 A (Table 3). The data was collected in 1.00 oscillation frames 35 over 1800 oscillation range on an 18cm MAR Research image WO99/10379 PCT/GB98/02542 -32 plate from a single crystal. The frames were processed with DENZO software (Otwinowski, 1993) resulting in 111,363 observations with I>1.0 o(I). Further scaling with the CCP4 suite gave 33,093 independent reflections 5 with Rmerge of 6.9%. Example 5 Structure Determination and Model Refinement. 10 The CCP4 package [Collaborative Computational Project, No. 4 Acta Crystallogr. D50, (1994) 760-763]. was used for all crystallographic calculations unless otherwise stated. The structure of the SM3-MUC1 peptide 15 complex was solved by the Molecular Replacement method as implemented in the program AMoRe [Navazza, J. Acta Crystallogr. A50, (1994) 157-163], using the Murine SE155-4 Fab fragment complexed with the dodecasaccharide [Cygler, M., Rose, D.R. and Bundle, D.R. Science 253, 20 (1991) 442-445] as a search model. A consistent solution for the rotation and translation function was obtained only after removing the bound antigen, CDRs and N- and C termini. Replacing all non-conserved residues with alanines and performing rigid body refinement with X-PLOR 25 [Brunger, A.T. (1992) X-PLOR, A System for Crystallography and NMR (Yale Univ. Press, New Haven, CT) Version 3.1] resulted in a crystallographic R-factor of 40%, with R-free of 49% as calculated against a randomly selected set of reflections [Brunger, A.T. Acta 30 Crystallogr. D49, (1993) 24-36]. At this stage, several omit maps were calculated covering the whole molecule, and the model was manually rebuilt using the program 0 [Jones, T.A. and Kjeldgaard, M. (1994) 0 - The Manual. Uppsala University, Sweden]. Further refinement of the 35 model was performed with the standard X-PLOR simulated WO99/10379 PCT/GB98/02542 -33 annealing protocol with resolution cut-off at 3.0 A, followed by manual rebuilding with 0 and Turbo-Frodo [A. Russel and C. Cambillau, Marseille, France]. The R factor converged to 34% (R-free 43%) and substantial, 5 continuously positive, electron density close to the CDRs became visible which corresponded to residues 2-10 of the peptide. The peptide was built into the density and further alternative rounds of refinement, DM solvent modification [Cowtan, K. Protein Crystallography 31, 10 (1994) 34-38] and manual rebuilding was carried out using REFMAC as implemented in the CCP4 package and X-PLOR, gradually increasing the resolution to 1.95 A. Inspection of the 2Fo-Fc and Fo-Fc difference Fourier maps showed significant positive electron density 15 corresponding to eight cadmium ions and a large number of solvent molecules. Several iterative refinement cycles were carried out, and the water and cadmium positions were checked after each cycle. All atoms were refined with individual isotropic B-factors. The Engh-Huber 20 parameters [Engh, R.A. and Huber, R. (1991) Accurate bond and angle parameters for X-ray protein structure refinement. Acta Crystallogr. A47, 392-400] as used in X-PLOR were altered to allow the Gly96H-Gln97H bond to adopt a cis conformation. No electron density was 25 visible for residues 128-133 of heavy chain as well as some terminal residues (L2, L209-212, H214, P1 and P11 13). For the same reason residues Asp41L, Glu123L, Glnl63L, GlnlH, Glu42H, Glu61H, Glu85H, Serl34H, Serl60H, Serl72H, Aspl73H, Ser203H, Lys208H and Ser2P were 30 modelled as Alanines. The final model contains 3227 atoms including the peptide, 333 water molecules, two chlorine and eight cadmium ions and the final refinement statistics are shown in Table 4. The overall quality of the model was checked with PROCHECK program. [Laskowski, 35 R.A., MacArthur, M.W., Moss, D.S. and Thornton, J.M. J.

WO99/10379 PCT/GB98/02542 -34 Appl. Crystallogr. 26, (1993) 283-291]. Buried contact surface areas were calculated with the program PDBAREA [Lee et al.J. Mol. Biol (1971), 55, 379-400 ]. It was noted that during the refinement and manual rebuilding 5 procedures, some of the SM3 primary sequence was incorrect. A cDNA corresponding the SM3 Fab region was sequenced confirming the errors in the SM3 sequence. The peptide was unambiguously built into the electron density from difference Fourier maps. Since the 10 MUC1 peptide is almost symmetrical, it was necessary to confirm the correct orientation for the peptide in the electron density. This was done by modelling the peptide backwards which resulted in a poorer fit into the density, and a higher R-Free and crystallographic R 15 factor after one round of refinement. The correctness of the cis-bond was confirmed by trying to refine it as a trans-bond. This resulted in a significant increase in main chain B-factors for Gly96H and subsequently poor quality electron density maps in 20 this region (data not shown). In addition, some potential hydrogen bonds between the peptide and antibody are not possible if the peptide bond is in trans conformation. Unrestrained refinement using REFMAC (CCP4, 1994) always resulted in a cis-conformation for 25 the Gly96H-Gln97H peptide bond, the electron density for which is shown in Figure 3. Example 6 The SM3 Fab fragment/MUC1 epitope structure. The structure of the SM3-peptide antigen complex 30 has revealed a number of unexpected-and new insights into how antibodies recognise peptide antigens. In particular CDR loop H3 contains a non-proline cis-peptide bond. The structure of the SM3 fab fragment/MUCl epitope was checked to a resolution of 1.95 A. All of the residues WO99/10379 PCT/GB98/02542 -35 of the epitope lie within favoured regions of the Ramachandran plot (data not shown) except for two residues (Thr51L, Ser93L) on CDRs (L2 and L3), both of which are involved in interactions with the bound 5 peptide. The individual atomic B-factors are within reasonable limits (average 16.3A 2 ), showing higher values only in residues located on mobile loops or solvent exposed fragments (data not shown). The quality of the density corresponding to nine residues of the MUC1 10 peptide antigen is shown in Figure 2A. The peptide residues have average atomic B-factors of 15.3A 2 indicating that the observed peptide is well ordered. There are eight cadmium sites in the SM3-peptide, five with full occupancy, and three with relative 15 occupancy of 0.75. They are mainly making contacts with the nitrogen atoms of histidines and carboxylic group of Glu or Asp residues between symmetry related molecules and/or chains (data not shown). All have distorted octahedral co-ordination completed by bound waters and 20 chloride ions. It appears that the cadmium ions stabilise contacts between chains or molecules and contribute to the crystal packing since crystallisation in the absence of cadmium produces tiny needles, too small for diffraction experiments. The SM3-cadmium 25 structure is an unusual example of a crystal structure in which cadmium ions were introduced directly and not simply by replacing other bound metal ions. SM3 - MUC1 peptide antigen interactions 30 The MUC1 peptide forms two intra-peptide hydrogen bonds: Pro 4 (atom O) to Thr 6 (atom N) and Asp 5 (atom OD1) to Arg 7 (atom N). The MUC1 peptide sits in an elongated groove of the SM3 antibody and is surrounded by all six CDR loops . 35 The peptide is anchored by the electrostatic interactions WO99/10379 PCT/GB98/02542 -36 of Asp5P and Arg7P and is bound to the SM3 antibody primarily by hydrophobic contacts (Table 4). All six CDRs of the SM3 antibody participate to some degree in the MUCi peptide binding, although of the residues on the 5 H2 chain only Arg52H makes contact with the peptide, and this through a water mediated interaction. The major contribution to antigen binding comes from HI, of which three residues Asn31H, Tyr32H, Trp33H are making contacts with seven residues of the peptide (Table 4). These 10 interactions cover 38% of the total CDRs surface area which is buried upon antibody-peptide binding, and are mainly hydrophobic, although there are some hydrogen bonds and salt bridges. The cis-peptide bond between Gly96H and Gln97H plays a crucial role in antigen binding 15 (Table 4). The nitrogen atom of Gly96H forms hydrogen bonds with both the carbonyl oxygen of Asp5P and the OD2 carboxyl group via a water molecule. The hydrophobic part of the Gln97H side chain interacts with Pro4P which is oriented between Trp33H (HI) and Tyr32L (Ll) . Pro4P 20 also stacks against Trp91L (L3), making Pro4P the most buried residue of the whole peptide antigen. The polar headgroup of Gln97H hydrogen bonds directly with residues of LI, L2 and Asp5P. The important antigenic residue Arg7P interacts with Tyr32H (H1) and Asn31H (HI) whilst 25 the C-terminal residues of the peptide sit in a hydrophobic pocket surrounded by Pro56L (L2), Phe27H (H1) and Tyr102H (H3). In summary, there are a number of direct water-mediated hydrogen bonds between the peptide and antibody (Table 4). The rest of the SM3-peptide 30 interactions are primarily hydrophobic. Hydrophobic contacts are dominant at the SM3 antibody combining face since out of a total 185 A2 antigen-antibody contact area, 128 A2 is covered by hydrophobic interactions (Table 5). A similarly high 35 ratio is also observed for the peptide antigen where 66% WO99/10379 PCT/GB98/02542 -37 of the buried surface area (total 603 A2 ) is represented by non-polar residues. Such high ratios would suggest that hydrophobic interactions are the main driving force in SM3-peptide complex formation. The average Fab 5 provides space for binding about 10 residues of peptide antigen, leaving the rest highly mobile and hence very often disordered and unobserved in electron density maps. There is a clear surface complementarity between the SM3 antibody and peptide antigen. Of particular interest is 10 the surface complementarity around Pro4P which appears to be facilitated by the presence of the cis-peptide bond within H3 (see later). A fragment search against a library of all antibody structures deposited in the Brookhaven database 15 (Bernstein et al., 1977) was unable to find a suitable replacement for H3. The best solution of the search, which used distances across the base of H3, placed the fragment Ca atoms at 2.6 A root mean squared separation from the equivalent crystal structure co-ordinates of H3. 20 However, it is well known that conformations of CDR H3 are difficult to classify and predict (Reczko et al., 1995; Shirai et al., 1996). In the SM3-peptide antigen structure, residues from CDRs Hl and to a lesser extent H3 are the major contributors to the binding of peptide 25 antigen (Table 4). This is in contrast to other antibody-peptide complexes where L3 and H3 (MacCallum et al., 1996) or H2 and H3 (Stanfield and Wilson, 1993) are the main contributors to antigen binding. One obvious conclusion from this is that it would be difficult to 30 predict, without a crystal structure of a complex, the expected contributions of each of the CDRs to peptide antigen binding. The presence of non-proline cis-peptide bonds within proteins is very rare with an estimated 0.05% of 35 known protein structures containing such bonds (Stewart WO99/10379 PCT/GB98/02542 -38 et al., 1990; Herzberg and Moult, 1991). To our knowledge, the SM3-peptide complex represents the first such example in a hypervariable loop region of an antibody combining site. Non-proline cis-peptide links 5 have however, been found in the active sites of a number of hydrolases (Perrakis et al., 1994). In these examples, the cis-peptide conformation is probably involved in facilitating contact and/or recognition of the substrate (Perrakis et al., 1994). Interestingly, to 10 date, all of the antibody-peptide structures contain a cis-proline residue within CDR L3, which is important for peptide-antigen binding. The reasons for the conservation of the cis-Pro is unclear, although it is interesting that the two residues on either side of the 15 cis-Pro, make at least one direct peptide contact and a second indirect contact, via other residue of the CDRs. The SM3 structure however, does not contain the equivalent proline in L3, but appears to have the cis peptide bond, albeit non-proline, on the opposite side of 20 the antibody combining face in H3. At least two conclusions can be drawn from these observations: (1) A cis-peptide bond within the antibody-antigen combining site is an important and common feature of peptide antigen binding; (2) The SM3-peptide complex differs from 25 all other antibody-peptide complexes in that the cis peptide bond is non-proline and is located in another CDR loop. As to the role of the cis-peptide bond, it may relate to specific interactions with the hydrophobic surface on the peptide antigen. An additional reason for 30 this bond to be cis rather than trans, may be due to the small size of H3 resulting from the extended peptide antigen epitope running across its upper surface. A small all-trans CDR would have less degrees of freedom to accommodate such a change.

WO99/10379 PCT/GB98/02542 -39 Comparison of bound and unbound MUCi peptide antigen A comparison of the SM3 bound MUCI peptide with the unbound solution structure obtained from NMR studies of 5 three MUCI repeats (Fontenot et al., 1995) is shown in Figure 4. The structure of the core region within each repeat in the solution structure is different to that of the antibody-bound peptide antigen. The overall geometry of the "knob-like" protrusion has changed from two 10 consecutive type II B-turns as observed in solution (Fontenot et al., 1995) to that of an essentially extended geometry when bound to the SM3 antibody. There are differences in all of the phi and psi torsion angles between the bound and unbound peptide, with the main 15 differences centred on the phi angles of Asp5P and Arg7P, which together make a significant percentage of the total peptide-contacts (Table 4). This rearrangement could keep the charged head groups partially solvated on antibody binding, thereby 20 presenting a predominantly hydrophobic surface to the SM3 antibody combining site. Thus, if the NMR structure of the MUC1 repeats represents the most prominent conformation in vivo (Fontenot et al., 1995), then the SM3 antibody induces a conformational change in the mucin 25 molecule upon binding, at least within the region of the peptide epitope. This would suggest that SM3-peptide recognition is by an "induced fit" mechanism.

WO 99/10379 PCT/GB98/02542 -40 References Bernstein, F.C., Koetzle, T.F., Williams, G.J.B., Meyer, E.F., Jr., Brice, M.D., Rogers, J.R., Kennard, O., Shimanouchi, T., Tasumi, M. (1977) The protein data 5 bank: A computer based archival file for macromolecular structures. J. Mol. Biol. 112, 535-542 Brunger, A.T. 19992) X-PLOR, A System for Crystallography and NMR (Yale Univ. Press, New Haven, CT) Version 3.1 10 Brunger, A.T. (1993) Assessment of phase accuracy by cross validation - the free R value - methods and applications. Acta Crystallogr. D49, 24-36 Burchell, J. and Taylor-Papadimitriou, J. (1993) Effect of modification of 15 carbohydrate side chains on the reactivity of antibodies with core-protein epitopes of the MUC1 gene product. Epithelial Cell Biol. 2, 155-162. Burchell, J., Gendler, s., Taylor-Papadimitriou, J., Girling, A., Lewis, A., Millis, R. and Lamport, D. (1987) Development and characterisation of breast cancer 2 0 reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res. 47, 5476-5482. Burchell, J., Taylor-Papadimitriou, J., Boshell, M., Gendler, D. and Duhig, T. (1989) A short sequence within the amino acid tandem repeat of a cancer associated 25 mucin, contains immunodominant epitopes. Int. J. Cancer 44, 691-696. Chothia, C., Lesk, A.M., Tramontano, A., Levitt, M., Smith-Gill, S.J., Air, G., Sheriff, S., Padlan, E.A., Davies, D., Tulip, W.R., Colman P.M., Spinelli, S., Alzari, P.M. and Poljak, R.J. (1989) Conformations of immunoglobulin 30 hypervariable regions. Nature (London) 342, 877-883.

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(1991) MOLSCRIPT: a program to produce both detailed and 20 schematic plots of protein structures. J. AppL. Crystallogr., 24, 946-950. Laskowski, R.A., MacArthur, M.W., Moss, D.S. and Thornton, J.M. (1993) PROCHECK: a program to check the stereochemical quality of protein 25 structures. J. Apple. Crystallogr. 26, 283-291. Lee, B., and Richards, F.M. (1971) The interpretation of protein structures. J. Mol. Biol, 55 , 379-400. 30 Lloyd, K., Burchell, J., Kudryashov, V., Yin, B.W.T. and Taylor-Papadimitriou, J. (1996) Comparison of 0-linked Carbohydrate Chains in MUC-1 Mucin from WO 99/10379 PCT/GB98/02542 -44 Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines. J. Biol. Chem., 271, 33325-33334. Matthews et al. (1968) J. Mol. Biol. 33, 491-497. 5 MacCallum, R.M., Martin, A.C.R. and Thronton, J.M. (1996) Antibody-antigen interactions: contact analysis and binding site topography. J. Mol. Biol. 262, 732 745. 10 Navazza, J. (1994) AMORE: An automated package for molecular replacement. Acta Crystallogr. A50, 157-163. Nicholls, A., Sharp, K. and Honig, b. (1991) Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. 15 Proteins 11, 281-296. Otwinowski (1993) DENZO. An oscillation data processing program for macromolecular crystallography. Yale University, New Haven, CT, USA. 2 0 Perrakis, A., Tews, I., Dauter, Z., Oppenheim, A.B., Chet, I., Wilson, K.S. and Vorgias, C.E. 91994) Crystal structure of bacterial chitinase at 2.3 A resolution. Structure 2, 1169-1180. Reczko, N., Martin A.C.R., Bohr. H. and Suhai, S. (1995) Prediction of 25 hypervariable cdr-h3 loop structures in antibodies. Prot. Eng. 8, 389-395. Rees, A.R., Staunton, D., Webster, D.M., Searle, S.J., Henry, A.H. and Pedersen, J.T. (1994) Antibody design - beyond the natural limits. Trends in Biotech. 12, 199 206. 30 WO 99/10379 PCT/GB98/02542 -45 Shirai, H., Kidera, A and Nakamura, H. (1996) Structural classification of cdr-h3 in antibodies. Febs. Lett. 399, 1-8. Stanfield, R.L. and Wilson, I.A. (1993) X-ray crystallographic studies of antibody 5 peptide complexes. Immunometh. 3, 211-221. Stewart, d.E., Sarkar, A and Wampler, J.E. (1990) Occurrence and role of cis peptide bonds in protein structures. J. Mol. Biol. 214, 253-260. 10 Teng (1990) J. AppL. Crystallogr. 23, 387-391. Wandall, H.H., Hassan H., Mirgorodskaya, E., Kristensen, A.K., Roepstorff, P., Bennett, E.P., Nieklsen, P.A., Hollingsworth, MA., Burchell, J., Taylor Papdimitriou, J. and Clausen H. (1997) Substrate specificities of three 15 members of the human UDP-N-acetyl-a-D-galactosamine: Polypeptide acetylgalactosaminyltransferase family, GalNAc-T1,-T2, and T3 J. Biol. Chem. (in press). Wallace et al.(1995) Protein Engineering. 8, 127-134. This software was used to 20 generate the LIGPLOT. Wilson, I.A. and Stanfield, R.L. (1994) Antibody-antigen interactions: new structures and new conformational changes. Curr. Opin. Struct. Biol. 4, 857-867. 25 30 WO99/10379 PCT/GB98/02542 -46 Table 1 Structure factors of the SM3 fragment/crystal peptide crystal which is described in the Examples 5 This table is shown below. The data is arranged in four separate columns as below. Each row of a column consisting of five numbers describes the results of a single reflection. Reading left to right, the first three numbers represent h, k and 1 respectively and are 10 the crystallographic reflection indices. The fourth number represents the structure factor F(hkl) defined as the computed sum of the Fourier series for each reflection hkl. As multiple measurements are made of the same reflection a standard deviation for each structure 15 factor has been provided as the fifth number in the row. Tables 2a and 2b Structure (atomic coordinates) of the 20 SM3 fraqment/crystal peptide crystal which is described in the Examples These tables are shown below. The top row, called CRYST1, defines the spacegroup and crystal cell 25 dimensions. Scale 1, Scale 2 and Scale 3 define an orthogonalisation matrix which when applied to the individual coordinates puts them into an orthogonal axis system i.e. 90 degrees between each of the axes x, y and z. 30 Below these rows reading left to right the second row gives the chemical symbol of the atom. OH2 represents a water molecule. The letter following indicates the position of the atom in the amino acid residue using a convention recognised by a skilled partisan. The letter 35 refers to the equivalent Greek symbol (i.e. A for alpha, WO99/10379 PCT/GB98/02542 -47 B for beta etc.). The third column gives the identity of the residue in which the atom is present. WAT represents a water molecule. The fifth column gives the number of the amino acid in the protein. The sixth, seventh and 5 eighth columns give the spatial position of the atom as x, y and z coordinates respectively. The ninth column shows the occupancy of that atom which will be 1.0 for present and 0.0 for absent (i.e. not observed) and the tenth column gives the B-factor which refers to the 10 mobility. 15 20 25 30 35 WO 99/10379 PCT/GB98/02542 -48 Table 1. -21 8 1 50.2 16.3 -20 4 5 40.9 16.3 -20 10 1 35.7 13.5 -21 0 1 132.8 9.3 -21 8 2 46.7 13.3 -20 4 6 118.7 8.2 -20 10 2 25.4 11.6 -21 0 2 172.8 12.6 -21 8 3 30.7 13.4 -20 4 7 49.1 14.0 -20 10 3 89.3 7.8 -21 0 3 124.7 10.3 -21 8 4 134.5 7.9 -20 4 8 74.8 6.8 -20 10 4 44.2 16.7 -21 0 4 183.9 7.7 -21 8 5 89.1 7.5 -20 4 9 39.5 12.9 -20 10 5 39.8 14.3 -21 0 5 160.3 19.4 -21 8 6 45.5 13.4 -20 4 10 181.5 6.0 -20 10 6 27.9 12.9 -21 0 6 152.0 14.3 -21 8 7 28.3 14.1 -20 4 11 137.8 5.3 -20 10 7 21.4 10.2 -21 0 7 87.1 11.0 -21 9 2 34.4 14.6 -20 4 12 88.2 6.2 -20 10 8 70.8 10.1 -21 0 8 96.3 9.2 -21 9 3 119.1 6.5 -20 4 13 151.8 5.7 -20 10 9 76.1 8.8 -21 0 9 41.4 19.9 -21 9 5 118.5 6.9 -20 4 14 31.1 12.9 -20 10 10 54.9 13.8 -21 0 10 114.6 15.0 -21 9 6 85.0 13.0 -20 5 1 89.1 8.7 -20 10 11 21.7 10.2 -21 1 1 22.8 11.0 -21 10 1 126.7 13.0 -20 5 2 36.5 14.5 -20 10 12 72.9 9.1 -21 1 2 109.3 11.7 -21 10 2 113.5 11.6 -20 5 3 98.3 7.1 -20 11 1 138.6 10.6 -21 1 3 46.8 18.7 -21 10 3 30.0 13.8 -20 5 4 19.0 9.4 -20 11 2 107.6 6.4 -21 1 4 58.2 13.4 -20 0 2 112.0 9.3 -20 5 5 168.0 5.4 -20 11 3 62.9 14.6 -21 1 5 102.7 10.0 -20 0 3 42.6 19.1 -20 5 6 106.6 7.0 -20 11 4 152.7 10.5 -21 1 6 21.7 10.7 -20 0 4 35.9 24.8 -20 5 8 95.6 6.6 -20 11 5 92.7 11.1 -21 1 7 60.1 12.3 -20 0 5 46.1 28.7 -20 5 9 88.3 7.4 -20 11 6 94.9 13.5 -21 1 8 73.2 7.8 -20 0 6 19.5 13.6 -20 5 10 170.3 5.3 -20 11 7 74.5 8.1 -21 1 10 95.2 18.3 -20 0 7 110.2 9.1 -20 5 11 92.9 7.3 -20 11 8 104.8 5.7 -21 2 1 63.4 12.1 -20 0 8 111.9 6.9 -20 5 12 63.6 13.0 -20 11 9 103.8 5.7 -21 2 2 77.5 17.8 -20 0 9 169.2 5.9 -20 5 13 114.7 5.0 -20 11 10 48.7 13.6 -21 2 3 42.2 15.8 -20 0 10 156.5 6.8 -20 5 14 24.0 10.9 -20 11 11 160.7 4.8 -21 2 4 117.3 10.0 -20 0 11 18.3 13.1 -20 6 1 70.6 14.9 -20 12 1 24.5 11.8 -21 2 5 73.3 15.1 -20 0 12 176.6 6.8 -20 6 2 29.0 12.8 -20 12 2 135.3 12.7 -21 2 6 89.8 10.2 -20 0 13 31.9 17.7 -20 6 3 112.6 7.5 -20 12 3 172.3 9.8 -21 2 7 54.3 12.8 -20 0 14 48.5 18.8 -20 6 4 99.3 8.2 -20 12 4 20.9 10.1 -21 2 8 18.0 9.0 -20 1 1 71.0 11.0 -20 6 5 99.5 6.7 -20 12 5 58.3 16.1 -21 2 9 36.7 14.5 -20 1 2 28.6 12.6 -20 6 6 190.6 7.1 -20 12 6 73.2 20.2 -21 2 10 109.9 13.3 -20 1 3 102.6 6.4 -20 6 8 43.7 13.0 -20 12 7 84.8 8.3 -21 3 1 75.6 9.7 -20 1 4 137.5 13.5 -20 6 9 112.5 6.2 -20 12 8 29.2 12.8 -21 3 2 77.7 18.4 -20 1 5 85.8 20.6 -20 6 10 69.2 9.3 -20 12 9 78.7 8.0 -21 3 3 32.4 13.9 -20 1 6 101.1 7.9 -20 6 11 141.8 5.1 -20 12 10 76.3 10.3 -21 3 4 34.7 13.7 -20 1 7 104.1 6.3 -20 6 12 66.2 12.1 -20 13 1 197.7 9.6 -21 3 5 42.5 14.0 -20 1 8 86.4 7.4 -20 6 13 84.8 6.7 -20 13 2 149.6 7.2 -21 3 6 173.0 6.9 -20 1 9 39.8 13.3 -20 6 14 190.8 7.0 -20 13 3 48.4 13.7 -21 3 7 67.2 11.0 -20 1 10 62.3 14.0 -20 7 1 173.9 9.1 -20 13 4 83.5 7.5 -21 3 8 104.2 5.9 -20 1 11 141.0 5.5 -20 7 2 111.4 14.2 -20 13 5 94.3 6.4 -21 3 9 37.4 14.8 -20 1 12 18.8 9.1 -20 7 3 59.0 17.7 -20 13 6 99.3 12.0 -21 4 1 30.9 13.4 -20 1 13 179.3 8.7 -20 7 4 125.5 7.5 -20 13 7 119.9 6.5 -21 4 2 21.8 10.5 -20 1 14 54.1 13.8 -20 7 5 186.8 4.8 -20 13 8 73.6 9.9 -21 4 3 76.4 10.8 -20 2 1 41.6 16.7 -20 7 6 96.2 7.6 -20 13 9 94.8 6.6 -21 4 4 149.5 6.1 -20 2 2 62.9 13.2 -20 7 7 189.9 11.2 -20 14 1 63.5 14.4 -21 4 5 24.9 11.7 -20 2 3 65.6 12.3 -20 7 8 21.3 10.7 -20 14 2 114.4 6.8 -21 4 6 41.2 15.4 -20 2 4 73.6 22.9 -20 7 9 110.5 6.9 -20 14 3 51.2 15.4 -21 4 7 53.1 15.6 -20 2 5 61.2 22.0 -20 7 10 89.4 6.8 -20 14 5 44.6 13.1 -21 4 8 93.8 9.6 -20 2 6 51.8 15.1 -20 7 11 51.7 12.3 -20 14 6 159.5 8.2 -21 4 9 22.2 10.7 -20 2 7 26.5 12.0 -20 7 12 130.5 6.0 -20 14 7 17.7 8.9 -21 5 1 27.8 13.0 -20 2 8 144.3 4.6 -20 7 13 33.8 12.7 -20 14 8 57.1 15.6 -21 5 2 113.4 11.7 -20 2 9 88.2 6.5 -20 8 1 179.9 8.5 -20 15 1 84.4 8.5 -21 5 3 44.4 18.1 -20 2 10 40.1 14.6 -20 8 2 171.7 8.0 -20 15 2 108.2 7.2 -21-5 4 54.6 16.2 -20 2 11 94.4 10.7 -20 8 3 223.0 8.0 -20 15 3 29.9 13.4 -21 5 5 64.2 13.2 -20 2 12 28.5 12.1 -20 8 4 83.0 8.6 -20 15 4 79.3 21.3 -21 5 6 152.4 10.5 -20 2 13 147.0 4.8 -20 8 5 23.5 11.0 -20 15 5 25.3 11.5 -21 5 7 107.0 22.2 -20 2 14 151.0 4.7 -20 8 6 98.3 6.1 -20 15 6 26.1 11.9 -21 5 8 26.8 12.0 -20 3 1 78.7 14.1 -20 8 7 46.7 16.9 -20 15 7 34.4 15.1 -21 5 9 117.3 5.8 -20 3 2 87.6 7.8 -20 8 8 67.9 11.0 -20 16 1 125.5 9.0 -21 6 1 87.8 8.1 -20 3 3 51.3 13.6 -20 8 9 90.5 7.2 -20 16 2 65.7 12.9 -21 6 2 41.2 15.9 -20 3 4 106.2 11.4 -20 8 10 88.8 6.9 -20 16 3 38.7 18.0 -21 6 3 90.2 11.7 -20 3 5 92.5 11.6 -20 8 11 97.2 6.0 -20 16 4 81.4 12.3 -21 6 4 81.2 8.7 -20 3 6 36.9 13.6 -20 8 12 45.0 13.3 -19 0 2 29.0 19.3 -21 6 6 62.7 13.0 -20 3 7 143.2 6.8 -20 8 13 96.2 7.2 -19 0 3 71.9 24.8 -21 6 7 23.2 11.6 -20 3 8 82.7 7.3 -20 9 1 58.1. 11.6 -19 0 4 46.3 28.7 -21 6 8 47.6 13.1 -20 3 9 20.2 9.6 -20 9 2 126.0 6.2 -19 0 5 183.1 14.1 -21 7 1 132.5 12.4 -20 3 11 125.4 5.7 -20 9 3 153.5 6.9 -19 0 6 266.6 7.7 -21 7 2 71.7 10.6 -20 3 12 63.0 8.5 -20 9 4 86.1 10.8 -19 0 7 209.2 5.6 -21 7 3 153.7 7.8 -20 3 13 127.1 7.6 -20 9 5 25.9 11.6 -19 0 8 76.4 9.5 -21 7 4 44.0 15.4 -20 3 14 55.1 13.6 -20 9 7 35.8 13.2 -19 0 9 40.4 18.1 -21 7 5 57.1 11.3 -20 4 1 108.5 9.5 -20 9 8 100.4 7.0 -19 0 10 111.1 7.1 -21 7 6 68.6 9.3 -20 4 2 60.3 12.0 -20 9 10 62.6 9.3 -19 0 11 127.2 6.7 -21 7 7 34.3 13.8 -20 4 3 33.2 13.2 -20 9 11 74.7 7.7 -19 0 12 94.7 10.3 -21 7 8 59.1 17.2 -20 4 4 104.1 7.3 -20 9 12 23.0 10.9 -19 0 13 88.2 9.9 WO 99/10379 PCT/GB98/02542 -49 -19 0 14 165.1 6.0 -19 5 3 144.5 6.1 -19 9 8 86.4 9.4 -19 14 4 204.1 8.9 -19 0 15 125.5 11.3 -19 5 4 105.2 14.3 -19 9 9 124.7 6.3 -19 14 5 184.7 9.5 -19 0 16 172.3 6.3 -19 5 5 106.5 8.0 -19 9 10 97.6 6.7 -19 14 6 143.3 5.3 -19 0 17 14.1 10.4 -19 5 6 218.2 4.5 -19 9 11 81.7 8.1 -19 14 7 63.9 9.7 -19 0 18 68.9 19.1 -19 5 7 121.5 6.1 -19 9 12 105.2 5.4 -19 14 8 32.9 13.7 -19 1 1 31.0 12.1 -19 5 8 79.7 8.8 -19 9 13 129.1 5.7 -19 14 9 79.6 10.1 -19 1 3 28.7 14.0 -19 5 9 149.1 4.4 -19 9 14 110.9 13.3 -19 14 10 81.3 7.4 -19 1 4 34.7 16.4 -19 5 10 117.5 5.5 -19 9 15 64.9 9.6 -19 14 11 110.2 5.2 -19 1 5 97.5 15.1 -19 5 11 17.3 8.7 -19 9 16 42.9 12.0 -19 14 12 114.0 5.0 -19 1 6 129.6 4.9 -19 5 12 110.1 6.5 -19 10 1 38.4 13.5 -19 14 13 65.2 7.9 -19 1 7 85.5 5.5 -19 5 13 82.4 7.7 -19 10 2 34.6 16.0 -19 15 1 141.1 7.4 -19 1 8 85.3 5.7 -19 5 14 32.9 13.0 -19 10 3 76.8 9.6 -19 15 2 168.2 10.1 -19 1 9 109.3 5.4 -19 5 15 95.6 9.0 -19 10 4 50.0 13.3 -19 15 3 142.7 11.6 -19 1 10 49.3 11.9 -19 5 16 28.7 12.3 -19 10 5 29.8 12.8 -19 15 4 141.2 6.6 -19 1 11 31.9 13.4 -19 5 17 118.5 7.8 -19 10 6 110.9 6.1 -19 15 5 161.3 8.0 -19 1 12 116.3 7.3 -19 6 1 96.2 6.1 -19 10 7 45.5 11.9 -19 15 6 66.3 7.9 -19 1 13 115.4 5.5 -19 6 2 59.1 11.0 -19 10 8 52.4 14.0 -19 15 7 73.0 7.8 -19 1 14 127.0 11.7 -19 6 3 26.3 12.3 -19 10 9 123.5 4.8 -19 15 8 65.9 7.0 -19 1 15 92.0 6.2 -19 6 4 38.8 12.9 -19 10 10 118.0 5.9 -19 15 9 57.6 9.1 -19 1 16 96.8 12.8 -19 6 5 150.5 6.5 -19 10 11 99.3 7.5 -19 15 10 112.0 5.6 -19 1 17 54.1 12.1 -19 6 6 68.8 10.3 -19 10 12 20.1 10.1 -19 15 11 36.8 14.3 -19 1 18 75.3 8.3 -19 6 7 122.4 5.6 -19 10 13 109.3 8.8 -19 15 12 54.9 11.9 -19 2 1 177.5 5.3 -19 6 8 119.3 6.7 -19 10 14 148.3 4.1 -19 16 1 56.4 15.6 -19 2 4 76.1 19.1 -19 6 9 73.9 7.1 -19 10 15 26.0 11.5 -19 16 2 66.1 10.9 -19 2 5 89.2 17.1 -19 6 10 34.2 12.8 -19 10 16 32.1 13.8 -19 16 3 33.6 13.3 -19 2 6 134.8 5.4 -19 6 11 130.5 6.7 -19 11 1 78.3 9.9 -19 16 4 151.6 8.5 -19 2 7 86.0 6.0 -19 6 12 59.4 9.5 -19 11 2 167.9 8.0 -19 16 5 87.9 9.0 -19 2 8 93.1 5.1 -19 6 13 153.1 6.3 -19 11 3 84.3 13.9 -19 16 6 32.0 15.3 -19 2 9 86.5 9.6 -19 6 14 114.6 5.9 -19 11 4 106.3 10.6 -19 16 7 105.9 19.9 -19 2 10 82.0 7.1 -19 6 15 237.7 4.7 -19 11 5 20.4 10.1 -19 16 8 81.5 5.5 -19 2 11 80.7 6.2 -19 6 16 86.3 5.8 -19 11 6 73.5 9.9 -19 16 9 164.0 4.0 -19 2 12 28.2 13.1 -19 6 17 22.2 10.6 -19 11 7 22.6 10.5 -19 16 10 84.7 8.3 -19 2 13 103.9 6.4 -19 7 1 96.2 6.0 -19 11 8 20.1 9.7 -19 16 11 89.3 6.7 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10.4 -17 6 1 200.5 4.1 -17 9 12 260.5 6.1 -18 22 1 20.1 10.1 -17 2 16 150.7 4.6 -17 6 2 53.4 10.4 -17 9 13 19.0 9.5 -18 22 2 38.8 18.3 -17 2 17 227.6 4.3 -17 6 3 121.0 5.4 -17 9 14 87.8 8.2 -18 22 3 56.8 17.0 -17 2 18 32.9 11.7 -17 6 4 23.3 11.1 -17 9 15 67.2 10.1 -18 22 4 35.3 14.4 -17 2 19 42.6 12.6 -17 6 5 102.4 8.3 -17 9 16 73.3 7.6 -18 22 5 97.6 11.6 -17 2 20 214.4 4.9 -17 6 6 70.9 7.7 -17 9 17 152.8 4.2 -18 22 6 40.9 15.0 -17 2 21 98.3 6.2 -17 6 7 119.9 4.7 -17 9 18 121.1 6.1 -18 22 7 58.1 22.6 -17 2 22 114.4 5.6 -17 6 8 50.6 9.2 -17 9 19 141.9 5.1 -18 22 8 46.1 18.4 -17 3 1 43.0 13.8 -17 6 9 122.2 4.7 -17 9 20 201.1 4.3 -18 22 9 74.9 9.8 -17 3 2 156.4 4.8 -17 6 10 242.9 4.9 -17 9 21 33.6 12.6 WO 99/10379 PCT/GB98/02542 -52 -17 10 1 118.8 4.5 -17 13 14 75.5 8.4 -17 17 15 22.2 10.1 -17 22 9 21.1 9.5 -17 10 2 78.4 7.0 -17 13 15 138.8 4.1 -17 17 16 19.3 9.3 -17 22 10 139.1 3.9 -17 10 3 109.1 10.2 -17 13 16 141.9 4.8 -17 17 17 145.9 4.5 -17 22 11 43.1 13.8 -17 10 4 54.2 8.5 -17 13 17 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5 17.9 8.6 -16 12 10 43.2 9.6 -16 2 24 159.5 4.8 -16 6 3 155.6 3.8 -16 9 6 126.5 4.2 -16 12 11 96.0 4.3 -16 3 1 100.7 8.0 -16 6 4 99.5 7.1 -16 9 7 117.3 4.3 -16 12 12 55.3 7.1 -16 3 2 138.0 8.5 -16 6 5 150.2 3.7 -16 9 8 212.6 5.4 -16 12 13 255.4 4.7 -16 3 3 197.1 3.9 -16 6 6 216.5 3.8 -16 9 9 148.4 3.6 -16 12 14 178.1 13.1 -16 3 4 31.6 11.5 -16 6 7 233.6 3.9 -16 9 10 172.5 3.6 -16 12 15 32.2 11.7 -16 3 5 167.7 3.5 -16 6 8 139.1 3.9 -16 9 11 15.6 7.6 -16 12 16 29.6 11.5 -16 3 6 105.1 4.6 -16 6 9 83.2 5.7 -16 9 12 214.5 3.9 -16 12 17 32.0 12.3 -16 3 7 238.8 4.0 -16 6 10 120.3 4.1 -16 9 13 245.2 4.4 -16 12 18 17.7 8.7 -16 3 8 112.7 3.9 -16 6 11 161.6 3.7 -16 9 14 19.7 9.7 -16 12 19 121.5 5.5 -16 3 9 109.5 6.3 -16 6 12 71.7 5.7 -16 9 15 126.7 10.0 -16 12 20 146.0 5.1 -16 3 10 75.3 7.4 -16 6 13 179.1 3.9 -16 9 16 110.3 5.6 -16 12 21 62.6 8.5 -16 3 11 116.5 4.3 -16 6 14 260.8 4.4 -16 9 17 63.7 8.5 -16 12 22 54.0 11.4 -16 3 12 81.2 6.4 -16 6 15 208.0 3.7 -16 9 18 57.3 8.2 -16 13 1 122.0 4.3 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105.3 4.4 -16 10 9 64.6 6.2 -16 13 16 139.5 3.7 -16 4 4 169.2 4.1 -16 7 6 178.8 3.6 -16 10 10 155.3 3.8 -16 13 17 18.9 9.2 -16 4 5 155.5 3.6 -16 7 7 171.5 3.7 -16 10 11 235.7 3.9 -16 13 18 70.1 7.7 -16 4 6 153.3 4.3 -16 7 8 67.2 8.6 -16 10 12 52.9 8.1 -16 13 19 255.8 4.6 -16 4 7 160.6 3.9 -16 7 9 200.9 3.6 -16 10 13 78.4 7.0 -16 13 20 131.9 5.5 -16 4 8 20.7 9.3 -16 7 10 140.2 3.5 -16 10 14 34.7 14.8 -16 13 21 78.7 7.5 -16 4 9 300.2 4.7 -16 7 11 107.5 3.9 -16 10 15 199.9 6.6 -16 13 22 22.2 10.6 -16 4 10 88.6 6.2 -16 7 12 16.7 8.2 -16 10 16 112.2 4.9 -16 14 1 161.7 4.0 -16 4 11 44.3 13.5 -16 7 13 313.9 5.6 -16 10 17 132.5 4.2 -16 14 2 210.6 3.9 WO 99/10379 PCT/GB98/02542 -54 -16 14 3 51.2 11.5 -16 17 13 117.9 5.3 -16 21 12 146.4 5.1 -16 26 9 38.9 10.6 -16 14 4 189.6 4.2 -16 17 14 93.4 5.5 -16 21 13 104.7 4.7 -16 26 10 58.6 6.8 -16 14 5 23.4 10.3 -16 17 15 94.3 7.2 -16 21 14 103.4 5.4 -16 26 11 77.8 6.4 -16 14 6 187.9 3.6 -16 17 16 175.7 4.0 -16 21 15 138.0 5.0 -16 27 1 85.3 5.6 -16 14 7 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6.8 -16 18 11 52.1 10.7 -16 22 12 108.5 4.6 -16 28 6 29.3 13.7 -16 14 21 52.5 14.4 -16 18 12 216.0 4.0 -16 22 13 165.3 4.7 -16 28 7 117.8 13.0 -16 15 1 92.2 6.6 -16 18 13 75.5 6.5 -16 22 14 105.6 5.8 -15 0 1 74.9 11.3 -16 15 2 152.7 4.6 -16 18 14 117.4 4.9 -16 22 15 39.2 12.2 -15 0 2 41.8 16.3 -16 15 3 79.9 5.6 -16 18 15 147.8 4.8 -16 22 16 38.2 12.0 -15 0 3 126.7 6.5 -16 15 4 176.9 6.0 -16 18 16 115.7 4.9 -16 23 1 102.9 4.8 -15 0 4 42.9 12.3 -16 15 5 253.8 9.1 -16 18 17 88.0 6.3 -16 23 2 80.7 9.0 -15 0 5 13.5 9.8 -16 15 6 108.6 3.9 -16 18 18 37.4 13.0 -16 23 3 107.5 10.8 -15 0 6 108.6 5.3 -16 15 7 71.5 7.3 -16 18 19 62.7 8.7 -16 23 4 203.5 5.8 -15 0 7 118.3 5.0 -16 15 8 173.1 4.1 -16 19 1 79.2 19.6 -16 23 5 81.3 7.9 -15 0 8 66.9 8.9 -16 15 9 138.7 3.8 -16 19 3 164.7 12.3 -16 23 6 121.4 6.0 -15 0 9 183.7 4.9 -16 15 10 16.9 8.3 -16 19 4 250.3 11.4 -16 23 7 135.4 5.2 -15 0 10 11.9 8.6 -16 15 11 167.0 9.9 -16 19 5 315.2 10.0 -16 23 8 116.3 3.7 -15 0 11 177.3 4.8 -16 15 12 143.8 13.7 -16 19 6 145.9 8.2 -16 23 9 116.4 4.2 -15 0 12 68.2 8.4 -16 15 13 113.4 4.5 -16 19 7 46.4 9.3 -16 23 10 181.5 3.9 -15 0 13 45.4 14.8 -16 15 14 241.5 4.0 -16 19 8 30.3 12.0 -16 23 11 85.0 6.9 -15 0 14 14.2 10.0 -16 15 15 21.1 9.6 -16 19 9 115.2 5.0 -16 23 12 18.8 9.3 -15 0 15 190.2 7.3 -16 15 16 112.4 5.0 -16 19 10 164.6 3.9 -16 23 13 144.6 4.1 -15 0 16 9.2 6.9 -16 15 17 115.5 4.8 -16 19 11 43.5 10.1 -16 23 14 55.6 8.4 -15 0 17 94.2 14.2 -16 15 18 220.7 4.3 -16 19 12 44.9 9.3 -16 23 15 78.8 7.7 -15 0 18 233.1 5.3 -16 15 19 109.1 5.5 -16 19 13 22.7 10.0 -16 24 1 122.7 8.8 -15 0 19 126.6 14.0 -16 15 20 179.6 4.1 -16 19 14 83.9 6.0 -16 24 2 62.9 9.9 -15 0 20 24.5 16.5 -16 15 21 91.1 8.3 -16 19 15 162.8 4.9 -16 24 3 89.2 6.4 -15 0 21 133.8 6.2 -16 16 1 34.4 11.7 -16 19 16 128.5 4.2 -16 24 4 79.0 7.3 -15 0 22 219.7 5.7 -16 16 2 124.7 5.2 -16 19 17 51.9 11.2 -16 24 5 86.9 8.2 -15 0 23 100.0 7.1 -16 16 3 128.9 4.1 -16 19 18 75.7 7.1 -16 24 6 48.2 9.5 -15 0 24 49.2 19.7 -16 16 4 151.2 4.0 -16 20 1 101.8 13.2 -16 24 7 87.5 5.6 -15 0 25 64.7 16.0 -16 16 5 102.3 5.0 -16 20 2 181.2 8.2 -16 24 8 89.5 6.8 -15 0 26 41.1 20.5 -16 16 6 103.9 4.3 -16 20 3 52.3 15.5 -16 24 9 37.9 11.7 -15 1 1 189.8 3.5 -16 16 7 179.2 5.2 -16 20 4 120.8 6.1 -16 24 10 98.3 5.2 -15 1 2 204.8 3.8 -16 16 8 49.2 11.1 -16 20 5 240.9 4.2 -16 24 11 20.6 9.6 -15 1 3 108.3 5.5 -16 16 9 53.1 15.0 -16 20 6 141.7 12.1 -16 24 12 114.2 4.7 -15 1 4 114.5 3.9 -16 16 10 249.3 12.7 -16 20 7 27.2 10.9 -16 24 13 92.2 5.9 -15 1 5 139.8 4.1 -16 16 11 27.4 12.2 -16 20 8 18.6 8.7 -16 24 14 35.2 12.6 -15 1 6 83.8 6.2 -16-16 12 173.2 4.2 -16 20 9 32.5 9.7 -16 25 1 128.0 4.2 -15 1 7 303.2 4.8 -16 16 13 76.8 6.4 -16 20 10 144.8 3.7 -16 25 2 42.4 12.9 -15 1 8 170.2 4.0 -16 16 14 187.8 4.1 -16 20 11 86.9 5.5 -16 25 3 161.6 8.0 -15 1 9 314.8 5.1 -16 16 15 45.8 10.5 -16 20 12 91.7 6.2 -16 25 4 122.4 6.3 -15 1 10 64.6 5.2 -16 16 16 144.0 4.3 -16 20 13 69.2 7.9 -16 25 5 116.5 4.6 -15 1 11 90.8 4.7 -16 16 17 93.3 6.0 -16 20 14 83.5 7.5 -16 25 6 61.7 9.9 -15 1 12 237.7 3.9 -16 16 18 24.3 10.8 -16 20 15 136.1 4.3 -16 25 7 82.0 6.3 -15 1 13 246.4 3.9 -16 16 19 157.7 4.5 -16 20 16 56.7 13.2 -16 25 8 121.3 3.6 -15 1 14 76.7 5.2 -16 16 20 28.9 11.5 -16 20 17 119.5 4.9 -16 25 9 145.4 3.7 -15 1 15 141.7 3.3 -16 17 1 228.7 4.8 -16 20 18 41.3 12.7 -16 25 10 66.2 6.9 -15 1 16 107.5 4.0 -16 17 2 59.5 8.9 -16 21 1 109.6 4.3 -16 25 11 114.6 4.6 -15 1 17 120.7 6.3 -16 17 3 123.8 4.2 -16 21 2 68.3 9.3 -16 25 12 36.7 12.0 -15 1 18 18.1 8.8 -16 17 4 147.5 5.5 -16 21 3 44.3 11.8 -16 25 13 70.3 9.6 -15 1 19 108.1 9.3 -16 17 5 104.6 5.1 -16 21 4 236.8 5.2 -16 26 1 66.5 17.4 -15 1 20 65.8 8.1 -16 17 6 31.6 12.1 -16 21 5 153.1 5.1 -16 26 2 68.8 8.4 -15 1 21 163.6 4.1 -16 17 7 197.7 3.6 -16 21 6 130.0 4.5 -16 26 3 169.2 6.2 -15 1 22 257.2 5.2 -16 17 8 57.7 8.1 -16 21 7 32.8 11.3 -16 26 4 48.4 10.4 -15 1 23 19.5 9.2 -16 17 9 246.7 5.9 -16 21 8 126.2 4.1 -16 26 5 38.6 10.8 -15 1 24 93.5 6.4 -16 17 10 108.4 6.5 -16 21 9 24.5 11.1 -16 26 6 107.5 9.6 -15 1 25 83.2 5.9 -16 17 11 27.5 10.7 -16 21 10 85.3 7.4 -16 26 7 40.0 18.2 -15 1 26 117.5 6.2 -16 17 12 73.4 6.1 -16 21 11 53.8 12.7 -16 26 8 115.3 6.2 -15 2 1 70.0 6.6 WO 99/10379 PCT/GB98/02542 -55 -15 2 2 70.0 7.6 -15 4 23 176.1 5.4 -15 7 21 116.9 4.7 -15 10 20 112.6 4.7 -15 2 3 287.6 5.4 -15 4 24 84.7 6.4 -15 7 22 47.5 12.9 -15 10 21 157.2 4.3 -15 2 4 125.2 3.3 -15 4 25 47.5 15.4 -15 7 23 173.3 5.5 -15 10 22 115.3 5.5 -15 2 5 167.9 3.6 -15 5 1 315.9 5.0 -15 7 24 79.6 7.4 -15 10 23 117.7 4.7 -15 2 6 222.0 3.7 -15 5 2 289.6 5.7 -15 7 25 78.7 8.7 -15 10 24 69.2 7.3 -15 2 7 165.8 3.6 -15 5 3 189.0 4.5 -15 8 1 187.6 5.1 -15 11 1 87.3 4.7 -15 2 8 139.5 3.9 -15 5 4 308.8 6.2 -15 8 2 78.1 6.3 -15 11 2 107.5 5.0 -15 2 9 244.6 4.3 -15 5 5 71.3 6.2 -15 8 3 168.1 5.6 -15 11 3 15.4 7.6 -15 2 10 127.4 4.1 -15 5 6 266.6 4.2 -15 8 4 154.1 5.4 -15 11 4 194.7 3.9 -15 2 11 122.9 3.9 -15 5 7 68.4 7.7 -15 8 5 52.4 6.2 -15 11 5 36.7 10.9 -15 2 12 96.8 4.4 -15 5 8 109.8 6.3 -15 8 6 126.7 3.7 -15 11 6 162.2 3.4 -15 2 13 104.1 4.3 -15 5 9 211.6 3.6 -15 8 7 144.6 3.3 -15 11 7 131.0 3.8 -15 2 14 132.3 3.8 -15 5 10 46.8 8.8 -15 8 8 103.8 3.7 -15 11 8 70.9 6.0 -15 2 15 105.8 4.3 -15 5 11 151.0 3.5 -15 8 9 36.0 12.1 -15 11 9 101.7 3.8 -15 2 17 170.4 4.4 -15 5 12 63.1 5.4 -15 8 10 95.8 4.3 -15 11 10 223.9 3.7 -15 2 18 147.7 4.1 -15 5 13 49.2 7.8 -15 8 11 104.1 4.7 -15 11 11 49.5 8.0 -15 2 19 131.2 14.1 -15 5 14 218.0 5.1 -15 8 12 20.7 9.2 -15 11 12 152.4 3.5 -15 2 20 126.4 5.0 -15 5 15 110.6 3.6 -15 8 13 49.8 11.0 -15 11 13 35.2 10.3 -15 2 21 239.1 5.3 -15 5 16 55.7 8.6 -15 8 14 77.0 5.4 -15 11 14 72.4 5.3 -15 2 22 169.5 7.3 -15 5 17 181.6 3.7 -15 8 15 96.3 5.1 -15 11 15 66.7 5.4 -15 2 23 144.4 6.1 -15 5 19 224.0 7.8 -15 8 16 73.4 5.5 -15 11 16 133.0 4.1 -15 2 24 68.2 8.3 -15 5 20 109.8 4.2 -15 8 17 120.6 4.5 -15 11 17 311.0 7.0 -15 2 25 216.1 4.4 -15 5 21 152.3 4.1 -15 8 18 226.2 7.1 -15 11 18 181.4 4.1 -15 2 26 117.0 6.5 -15 5 22 41.9 13.5 -15 8 19 146.4 4.4 -15 11 19 88.9 6.6 -15 3 1 276.5 4.4 -15 5 23 101.3 8.1 -15 8 20 49.8 9.4 -15 11 20 83.6 6.7 -15 3 2 133.5 4.9 -15 5 24 62.9 8.9 -15 8 21 212.6 4.0 -15 11 21 217.3 4.9 -15 3 3 135.7 7.2 -15 5 25 115.9 6.6 -15 8 22 133.4 5.0 -15 11 22 117.6 4.6 -15 3 4 119.7 3.9 -15 6 1 108.6 4.2 -15 8 23 116.2 8.8 -15 11 23 79.0 6.6 -15 3 5 249.7 3.8 -15 6 2 218.6 4.7 -15 8 24 70.7 10.2 -15 11 24 89.5 7.4 -15 3 6 193.5 3.5 -15 6 3 152.1 4.8 -15 8 25 113.5 5.8 -15 12 1 136.9 3.5 -15 3 7 209.6 4.2 -15 6 4 41.8 11.2 -15 9 1 222.3 4.4 -15 12 2 145.5 4.4 -15 3 8 203.9 5.4 -15 6 5 155.0 3.7 -15 9 2 181.1 3.8 -15 12 3 12.4 6.3 -15 3 9 78.5 5.2 -15 6 6 48.1 8.8 -15 9 3 171.2 4.3 -15 12 4 166.2 3.8 -15 3 10 293.8 4.8 -15 6 7 212.3 3.8 -15 9 4 285.1 5.2 -15 12 5 148.4 3.9 -15 3 11 179.2 4.1 -15 6 8 47.0 7.5 -15 9 5 72.7 6.8 -15 12 6 337.4 4.9 -15 3 12 129.0 3.6 -15 6 9 170.6 3.5 -15 9 6 141.7 3.8 -15 12 7 119.0 4.4 -15 3 13 126.3 5.9 -15 6 10 196.3 3.5 -15 9 7 155.1 3.8 -15 12 8 136.7 3.3 -15 3 14 110.5 4.0 -15 6 11 25.6 10.5 -15 9 8 96.8 3.7 -15 12 9 324.0 4.7 -15 3 15 15.1 7.5 -15 6 12 156.4 3.6 -15 9 9 183.5 4.1 -15 12 10 49.5 9.2 -15 3 16 172.1 3.7 -15 6 13 86.0 5.6 -15 9 10 333.6 4.8 -15 12 11 116.2 4.3 -15 3 17 131.1 4.2 -15 6 14 101.1 3.9 -15 9 11 127.9 3.2 -15 12 12 75.9 5.0 -15 3 18 174.4 4.9 -15 6 15 42.0 11.9 -15 9 12 128.7 3.6 -15 12 13 165.8 4.4 -15 3 19 162.9 9.4 -15 6 16 143.5 3.9 -15 9 13 20.9 9.7 -15 12 14 176.0 3.7 -15 3 20 113.6 4.4 -15 6 17 115.6 3.8 -15 9 14 164.7 3.6 -15 12 15 147.8 3.7 -15 3 21 173.3 4.0 -15 6 18 46.8 14.8 -15 9 15 50.0 11.2 -15 12 16 50.5 19.2 -15 3 22 56.0 17.2 -15 6 19 211.8 5.8 -15 9 16 94.4 5.3 -15 12 17 69.0 7.4 -15 3 23 146.0 4.4 -15 6 20 118.4 4.2 -15 9 17 74.5 7.2 -15 12 18 78.5 6.9 -15 3 24 76.5 7.5 -15 6 21 78.9 8.0 -15 9 18 217.9 10.5 -15 12 19 118.9 4.1 -15 3 25 86.8 6.3 -15 6 22 122.8 5.7 -15 9 19 131.7 6.0 -15 12 20 77.5 7.3 -15 3 26 170.0 5.4 -15 6 23 94.9 9.9 -15 9 20 123.2 5.1 -15 12 21 214.4 4.1 -15 4 1 109.6 4.5 -15 6 24 25.4 11.5 -15 9 21 135.0 5.2 -15 12 22 125.6 5.2 -15-4 2 312.7 6.6 -15 6 25 131.0 5.3 -15 9 22 40.5 14.7 -15 12 23 60.5 10.9 -15 4 3 141.1 4.7 -15 7 1 261.3 5.0 -15 9 23 188.5 4.3 -15 12 24 35.5 12.6 -15 4 4 151.5 4.1 -15 7 2 82.9 6.6 -15 9 24 56.2 10.8 -15 13 1 77.9 6.6 -15 4 5 28.9 11.2 -15 7 3 249.3 4.4 -15 9 25 48.5 10.6 -15 13 2 58.6 6.3 -15 4 6 99.0 4.5 -15 7 4 41.4 15.4 -15 10 1 241.6 6.0 -15 13 3 255.9 5.0 -15 4 7 161.5 3.8 -15 7 5 219.7 4.2 -15 10 2 201.9 3.8 -15 13 4 27.4 10.8 -15 4 8 67.3 7.2 -15 7 6 162.5 3.8 -15 10 3 280.4 6.2 -15 13 5 82.2 4.3 -15 4 9 111.2 3.7 -15 7 7 185.6 3.9 -15 10 4 181.3 4.5 -15 13 6 127.2 4.1 -15 4 10 148.7 3.2 -15 7 8 78.4 4.6 -15 10 5 79.3 6.2 -15 13 7 146.9 3.2 -15 4 11 194.0 3.3 -15 7 9 191.3 7.0 -15 10 6 33.8 10.4 -15 13 8 160.1 3.3 -15 4 12 59.9 6.0 -15 7 10 133.5 3.7 -15 10 7 23.7 9.7 -15 13 9 145.5 3.9 -15 4 13 98.4 4.5 -15 7 11 99.2 6.4 -15 10 8 214.7 3.6 -15 13 10 165.4 3.5 -15 4 14 135.5 4.1 -15 7 12 144.2 3.4 -15 10 9 88.4 4.5 -15 13 11 12.5 6.3 -15 4 15 115.0 4.2 -15 7 13 81.7 5.3 -15 10 10 74.1 5.0 -15 13 12 92.5 4.6 -15 4 16 24.5 10.3 -15 7 14 272.5 4.3 -15 10 11 37.9 13.6 -15 13 13 196.2 4.1 -15 4 17 118.1 4.3 -15 7 15 56.6 7.1 -15 10 12 251.6 3.9 -15 13 14 19.5 9.0 -15 4 18 175.6 4.6 -15 7 16 100.4 4.9 -15 10 13 238.4 3.8 -15 13 15 174.3 3.8 -15 4 19 280.6 7.1 -15 7 17 96.9 5.0 -15 10 14 111.2 4.4 -15 13 16 196.5 7.4 -15 4 20 207.4 4.0 -15 7 18 17.3 8.7 -15 10 15 50.4 7.9 -15 13 17 55.4 8.2 -15 4 21 136.4 4.4 -15 7 19 117.5 7.1 -15 10 16 317.0 4.9 -15 13 18 78.5 7.0 -15 4 22 96.8 6.9 -15 7 20 28.1 11.1 -15 10 19 60.2 8.2 -15 13 19 139.6 4.2 WO 99/10379 PCT/GB98/02542 -56 -15 13 20 56.3 11.8 -15 17 3 116.6 4.6 -15 20 13 220.5 4.6 -15 24 15 79.2 6.5 -15 13 21 86.4 6.8 -15 17 4 142.6 3.9 -15 20 14 138.2 4.5 -15 24 16 77.9 6.0 -15 13 22 164.3 4.6 -15 17 5 153.5 5.6 -15 20 15 57.3 10.4 -15 24 17 15.2 7.7 -15 14 1 109.8 5.2 -15 17 6 91.9 5.6 -15 20 16 54.8 8.0 -15 25 1 113.4 5.8 -15 14 2 108.6 4.1 -15 17 7 102.5 5.5 -15 20 17 119.6 6.5 -15 25 2 19.3 9.2 -15 14 3 152.9 3.9 -15 17 8 98.9 5.0 -15 20 18 33.6 12.2 -15 25 3 136.5 5.3 -15 14 4 197.8 4.5 -15 17 9 140.5 3.6 -15 20 19 168.6 4.3 -15 25 4 103.3 9.1 -15 14 5 54.4 10.9 -15 17 10 143.6 3.5 -15 20 20 38.6 12.2 -15 25 5 83.6 5.0 -15 14 6 86.4 4.3 -15 17 11 43.9 9.0 -15 21 1 66.5 6.0 -15 25 6 172.1 4.7 -15 14 7 136.5 3.9 -15 17 13 234.2 9.4 -15 21 2 148.8 4.0 -15 25 7 106.1 6.1 -15 14 8 184.3 3.5 -15 17 14 141.9 4.6 -15 21 4 15.1 7.6 -15 25 8 179.7 4.1 -15 14 9 198.6 3.5 -15 17 15 113.6 4.0 -15 21 6 16.3 8.3 -15 25 9 102.0 4.3 -15 14 10 160.6 3.3 -15 17 16 205.4 4.0 -15 21 7 149.5 7.7 -15 25 10 115.0 4.3 -15 14 11 134.9 3.7 -15 17 17 122.6 4.4 -15 21 8 186.8 10.0 -15 25 11 94.4 5.6 -15 14 12 64.4 6.4 -15 17 18 184.7 4.1 -15 21 10 176.9 4.1 -15 25 12 82.1 5.8 -15 14 13 128.4 3.6 -15 17 19 345.5 4.8 -15 21 11 67.8 6.9 -15 25 13 98.8 6.5 -15 14 14 91.5 5.0 -15 17 20 228.5 4.2 -15 21 12 170.0 3.6 -15 25 14 59.1 8.4 -15 14 15 215.7 6.0 -15 17 21 81.7 6.2 -15 21 13 20.5 9.4 -15 25 15 77.4 5.1 -15 14 16 19.0 9.3 -15 17 22 117.7 7.3 -15 21 14 73.8 6.6 -15 25 16 76.7 8.5 -15 14 17 77.4 6.2 -15 18 1 47.7 10.3 -15 21 15 229.4 3.9 -15 26 1 78.9 7.3 -15 14 18 130.7 4.0 -15 18 2 151.4 5.8 -15 21 16 154.8 5.2 -15 26 2 75.2 7.3 -15 14 19 181.9 4.3 -15 18 3 214.7 4.5 -15 21 17 13.7 6.9 -15 26 3 96.7 6.1 -15 14 20 109.9 5.1 -15 18 4 30.0 11.4 -15 21 18 174.6 4.0 -15 26 4 97.7 4.7 -15 14 21 16.8 8.5 -15 18 5 233.5 5.7 -15 21 19 93.7 6.8 -15 26 5 139.9 7.3 -15 14 22 74.7 7.9 -15 18 6 134.5 3.3 -15 22 1 135.0 14.4 -15 26 6 109.3 4.1 -15 14 23 33.1 13.2 -15 18 7 126.5 3.6 -15 22 2 72.4 14.0 -15 26 7 86.3 6.0 -15 15 1 17.6 8.5 -15 18 8 64.8 7.7 -15 22 3 168.8 14.2 -15 26 8 108.9 4.5 -15 15 2 141.3 4.2 -15 18 9 43.6 8.6 -15 22 4 214.7 11.1 -15 26 9 74.6 7.3 -15 15 3 57.1 6.8 -15 18 10 184.2 3.6 -15 22 5 281.7 8.4 -15 26 10 23.0 10.0 -15 15 4 181.3 5.0 -15 18 11 33.3 12.2 -15 22 6 89.8 9.9 -15 26 11 50.3 11.4 -15 15 5 86.7 6.2 -15 18 12 204.9 6.9 -15 22 7 78.5 6.0 -15 26 12 78.3 7.5 -15 15 6 154.5 3.2 -15 18 13 16.1 7.9 -15 22 8 12.8 6.5 -15 26 13 84.8 7.4 -15 15 7 149.0 3.5 -15 18 14 37.2 10.5 -15 22 9 87.0 5.0 -15 26 14 65.2 8.2 -15 15 8 263.7 4.3 -15 18 15 93.6 5.3 -15 22 10 136.8 5.7 -15 27 1 60.5 6.5 -15 15 9 90.7 4.3 -15 18 16 88.8 6.0 -15 22 11 79.4 5.4 -15 27 2 64.0 13.4 -15 15 10 69.4 6.6 -15 18 17 77.8 6.1 -15 22 12 43.7 10.3 -15 27 3 83.4 9.0 -15 15 11 85.4 5.4 -15 18 18 181.4 4.1 -15 22 13 195.2 3.9 -15 27 4 188.8 6.6 -15 15 12 91.0 4.7 -15 18 19 37.7 11.7 -15 22 14 255.9 4.7 -15 27 5 160.7 7.3 -15 15 13 20.2 9.2 -15 18 20 21.6 10.6 -15 22 15 168.6 3.7 -15 27 6 72.6 6.6 -15 15 14 54.6 8.8 -15 18 21 114.2 5.0 -15 22 16 191.9 4.2 -15 27 7 93.6 4.3 -15 15 15 134.1 10.1 -15 19 1 121.7 3.8 -15 22 17 210.4 4.0 -15 27 8 161.4 5.1 -15 15 16 118.5 5.4 -15 19 2 23.4 10.0 -15 22 18 45.9 13.6 -15 27 9 142.9 3.8 -15 15 17 191.9 3.8 -15 19 3 167.7 4.3 -15 23 1 221.6 5.9 -15 27 10 95.4 4.1 -15 15 18 402.0 6.3 -15 19 4 122.1 4.6 -15 23 3 53.5 15.5 -15 27 11 57.2 7.2 -15 15 19 118.9 4.5 -15 19 5 148.9 3.4 -15 23 5 165.0 3.7 -15 27 12 168.3 4.3 -15 15 20 53.3 12.8 -15 19 6 164.3 3.7 -15 23 6 36.2 14.3 -15 27 13 88.3 7.4 -15 15 21 199.6 4.7 -15 19 7 49.6 7.4 -15 23 7 94.4 4.6 -15 28 1 14.4 7.2 -15 15 22 47.5 11.5 -15 19 8 86.6 4.2 -15 23 8 170.7 3.6 -15 28 2 61.7 16.5 -15 15 23 71.5 9.4 -15 19 9 120.1 3.9 -15 23 9 30.6 10.7 -15 28 3 148.4 4.1 -15 16 1 50.1 10.6 -15 19 10 122.5 4.3 -15 23 10 212.2 4.5 -15 28 4 30.2 13.0 -15 16 2 85.2 5.5 -15 19 11 257.8 6.5 -15 23 11 61.8 7.0 -15 28 5 60.1 9.3 -15 -16 3 79.0 6.3 -15 19 12 27.0 10.4 -15 23 12 162.0 3.6 -15 28 6 69.4 6.1 -15 16 4 84.6 4.9 -15 19 13 33.9 10.7 -15 23 13 83.1 5.3 -15 28 7 62.8 19.4 -15 16 5 47.8 7.1 -15 19 14 195.4 3.6 -15 23 14 82.8 5.1 -15 28 8 74.0 5.3 -15 16 6 150.7 3.4 -15 19 15 88.2 6.6 -15 23 15 126.1 4.1 -15 28 9 127.4 4.1 -15 16 7 23.9 10.0 -15 19 16 102.7 5.8 -15 23 16 278.0 4.9 -15 28 10 102.0 4.4 -15 16 8 15.9 7.6 -15 19 17 141.5 4.7 -15 23 17 259.7 4.5 -15 28 11 65.5 8.0 -15 16 9 102.8 4.3 -15 19 18 143.8 7.0 -15 23 18 105.8 9.7 -15 29 1 20.4 9.6 -15 16 10 89.3 5.5 -15 19 19 32.7 11.2 -15 24 1 97.1 8.1 -15 29 2 47.2 14.3 -15 16 11 222.5 3.8 -15 19 20 101.5 6.7 -15 24 2 133.5 4.4 -15 29 3 184.1 5.9 -15 16 12 100.2 4.2 -15 20 1 128.0 10.9 -15 24 3 90.3 6.7 -15 29 4 105.7 3.8 -15 16 14 349.7 8.7 -15 20 2 51.1 9.5 -15 24 4 15.9 7.6 -15 29 5 61.1 15.8 -15 16 15 274.9 4.5 -15 20 3 130.1 5.2 -15 24 5 24.8 12.2 -15 29 6 57.4 10.2 -15 16 16 69.9 6.8 -15 20 4 94.0 5.6 -15 24 6 98.9 4.5 -15 29 7 46.7 9.5 -15 16 17 113.3 5.5 -15 20 5 82.9 7.2 -15 24 7 80.7 5.5 -15 29 8 48.9 9.6 -15 16 18 209.8 4.0 -15 20 6 77.3 5.0 -15 24 8 159.8 3.6 -15 29 9 114.4 4.6 -15 16 19 126.1 4.0 -15 20 7 128.8 3.8 -15 24 9 84.0 5.0 -15 29 10 60.8 7.9 -15 16 20 119.9 5.2 -15 20 8 107.2 6.8 -15 24 10 43.8 9.7 -15 30 1 100.2 4.8 -15 16 21 107.1 6.1 -15 20 9 225.6 12.3 -15 24 11 110.3 4.1 -15 30 2 114.0 5.7 -15 16 22 150.0 4.3 -15 20 10 104.8 9.0 -15 24 12 134.6 3.8 -15 30 3 138.4 4.6 -15 17 1 121.5 4.1 -15 20 11 115.1 4.3 -15 24 13 89.3 5.1 -15 30 4 80.7 6.9 -15 17 2 100.5 5.3 -15 20 12 118.5 4.2 -15 24 14 118.4 4.5 -15 30 5 32.3 10.3 WO 99/10379 PCT/GB98/02542 -57 -15 30 6 18.4 9.2 -14 2 17 181.9 3.8 -14 5 8 360.1 4.9 -14 8 1 147.1 6.1 -15 30 7 27.9 13.0 -14 2 18 54.9 7.1 -14 5 9 81.1 5.5 -14 8 2 289.9 6.0 -14 0 1 108.9 6.1 -14 2 19 190.1 4.0 -14 5 10 248.7 4.6 -14 8 3 250.4 4.5 -14 0 2 368.5 7.4 -14 2 20 126.9 3.9 -14 5 11 103.2 5.5 -14 8 4 116.7 3.7 -14 0 3 246.8 5.6 -14 2 21 223.8 8.3 -14 5 12 377.9 5.7 -14 8 5 22.1 9.6 -14 0 4 254.3 6.1 -14 2 22 125.4 4.7 -14 5 13 157.6 3.9 -14 8 6 100.9 3.7 -14 0 5 94.5 6.3 -14 2 23 202.6 4.4 -14 5 14 126.0 3.7 -14 8 7 337.3 5.1 -14 0 6 90.3 17.1 -14 2 24 130.2 6.4 -14 5 15 218.1 3.3 -14 8 8 111.0 3.6 -14 0 7 111.9 12.0 -14 2 25 75.4 8.4 -14 5 16 147.4 4.0 -14 8 9 167.0 3.9 -14 0 8 15.8 10.9 -14 2 26 107.9 6.4 -14 5 17 41.0 11.8 -14 8 10 35.0 11.5 -14 0 9 55.0 16.7 -14 2 27 105.8 5.4 -14 5 18 42.0 10.1 -14 8 11 187.6 3.3 -14 0 10 234.5 7.5 -14 3 1 129.0 4.8 -14 5 19 66.9 7.9 -14 8 12 87.2 5.0 -14 0 11 308.3 6.1 -14 3 2 253.4 4.3 -14 5 20 159.9 5.1 -14 8 13 120.1 6.7 -14 0 12 157.3 4.8 -14 3 3 202.0 5.6 -14 5 21 120.5 12.6 -14 8 14 75.0 4.8 -14 0 13 345.6 7.4 -14 3 4 63.6 5.3 -14 5 22 111.3 4.5 -14 8 15 138.3 3.9 -14 0 14 188.0 5.1 -14 3 5 291.2 4.4 -14 5 23 105.5 4.5 -14 8 16 74.8 6.1 -14 0 15 135.5 4.9 -14 3 6 266.8 5.2 -14 5 24 84.5 6.0 -14 8 17 159.8 3.5 -14 0 16 8.9 6.7 -14 3 7 116.9 6.7 -14 5 25 71.1 8.0 -14 8 18 213.2 5.0 -14 0 17 93.4 5.9 -14 3 8 159.6 3.3 -14 5 26 109.5 6.5 -14 8 19 135.9 5.2 -14 0 18 125.2 4.8 -14 3 9 217.8 5.7 -14 5 27 149.2 4.2 -14 8 20 269.3 9.3 -14 0 19 42.9 14.7 -14 3 10 60.8 6.0 -14 6 1 239.0 3.9 -14 8 21 84.3 6.3 -14 0 20 52.0 16.6 -14 3 11 194.2 4.1 -14 6 2 201.8 4.0 -14 8 22 99.9 4.8 -14 0 21 114.6 14.7 -14 3 12 206.6 4.1 -14 6 3 51.3 13.4 -14 8 23 76.9 6.7 -14 0 22 11.7 8.6 -14 3 13 187.0 3.4 -14 6 4 237.1 3.9 -14 8 24 75.4 6.9 -14 0 23 162.3 6.0 -14 3 14 99.9 3.6 -14 6 5 25.0 10.4 -14 8 25 133.8 4.6 -14 0 24 247.4 6.2 -14 3 15 101.0 5.0 -14 6 6 292.7 4.8 -14 8 26 88.9 6.7 -14 0 25 162.8 10.0 -14 3 16 48.1 9.8 -14 6 7 178.4 3.5 -14 9 1 50.7 11.3 -14 0 26 46.9 18.4 -14 3 17 143.7 5.3 -14 6 8 154.8 4.5 -14 9 2 154.2 4.4 -14 0 27 154.6 5.8 -14 3 18 141.0 3.5 -14 6 9 149.2 3.3 -14 9 3 126.4 5.0 -14 1 1 92.2 4.5 -14 3 19 205.0 3.9 -14 6 10 251.3 3.8 -14 9 4 63.1 7.7 -14 1 2 109.9 5.3 -14 3 20 297.4 4.9 -14 6 11 38.6 9.2 -14 9 5 147.7 4.1 -14 1 3 173.9 3.9 -14 3 21 291.5 6.6 -14 6 12 263.5 4.2 -14 9 6 58.9 5.8 -14 1 4 219.2 4.0 -14 3 22 89.3 6.6 -14 6 13 297.3 4.5 -14 9 7 154.4 3.5 -14 1 5 193.3 3.5 -14 3 23 112.9 4.9 -14 6 14 148.9 3.8 -14 9 8 149.9 3.2 -14 1 6 383.9 5.9 -14 3 24 157.6 4.8 -14 6 15 56.7 7.3 -14 9 9 66.6 6.7 -14 1 7 211.2 4.6 -14 3 25 64.3 8.7 -14 6 16 161.0 3.5 -14 9 10 55.7 5.6 -14 1 8 78.4 4.8 -14 3 26 114.7 6.0 -14 6 17 251.5 3.7 -14 9 11 251.6 4.7 -14 1 9 186.2 3.5 -14 3 27 132.3 4.5 -14 6 18 74.6 5.7 -14 9 12 333.4 4.3 -14 1 10 118.6 3.8 -14 4 1 191.4 4.5 -14 6 19 218.8 3.8 -14 9 13 91.6 4.3 -14 1 11 140.9 3.7 -14 4 2 164.3 3.7 -14 6 20 120.0 11.8 -14 9 14 219.8 3.7 -14 1 12 289.0 4.1 -14 4 3 301.2 5.3 -14 6 21 37.3 14.6 -14 9 15 71.1 5.4 -14 1 13 403.8 6.2 -14 4 4 112.9 3.5 -14 6 22 155.0 4.4 -14 9 16 116.1 3.9 -14 1 14 85.0 4.8 -14 4 5 205.3 3.7 -14 6 23 53.6 8.0 -14 9 17 176.8 3.8 -14 1 15 172.1 3.9 -14 4 6 172.1 3.4 -14 6 24 188.0 4.1 -14 9 18 144.7 4.0 -14 1 16 257.2 4.2 -14 4 7 117.2 4.8 -14 6 25 65.6 8.3 -14 9 19 40.5 11.0 -14 1 17 234.6 3.9 -14 4 8 264.9 4.2 -14 6 26 97.4 7.5 -14 9 20 230.6 10.1 -14 1 18 193.3 3.6 -14 4 9 107.8 3.7 -14 6 27 19.7 9.6 -14 9 21 248.4 4.3 -14 1 19 177.9 5.6 -14 4 10 221.9 4.2 -14 7 1 95.3 7.6 -14 9 22 184.0 4.2 -14 1 20 210.4 3.8 -14 4 11 152.6 3.8 -14 7 2 308.0 4.5 -14 9 23 167.5 4.2 -14 1 21 196.4 8.4 -14 4 12 196.0 3.4 -14 7 3 112.7 4.8 -14 9 24 171.1 5.8 -14 1 22 180.0 4.3 -14 4 13 170.1 3.3 -14 7 4 117.7 5.1 -14 9 25 174.1 4.3 -14-1 23 160.0 4.0 -14 4 14 123.2 4.0 -14 7 5 197.0 3.7 -14 9 26 67.6 9.2 -14 1 24 148.2 4.8 -14 4 15 108.9 4.3 -14 7 6 308.3 4.3 -14 10 1 115.4 5.2 -14 1 25 169.8 4.5 -14 4 16 201.9 4.1 -14 7 7 202.0 3.9 -14 10 2 298.7 5.0 -14 1 26 162.7 4.5 -14 4 17 57.7 7.3 -14 7 8 194.7 3.3 -14 10 3 231.4 4.6 -14 1 27 106.6 5.0 -14 4 18 20.6 9.2 -14 7 9 383.0 5.4 -14 10 4 61.6 6.5 -14 2 1 39.0 10.6 -14 4 19 313.6 4.4 -14 7 10 423.9 5.5 -14 10 5 385.9 5.7 -14 2 2 137.7 4.7 -14 4 20 51.8 9.8 -14 7 11 40.1 8.1 -14 10 6 14.9 7.4 -14 2 3 191.9 4.4 -14 4 21 283.2 6.0 -14 7 12 250.9 4.6 -14 10 7 110.6 3.5 -14 2 4 274.0 4.8 -14 4 22 150.4 4.5 -14 7 13 194.0 3.3 -14 10 8 62.0 6.1 -14 2 5 235.5 3.9 -14 4 23 97.1 4.8 -14 7 14 127.4 4.5 -14 10 9 194.5 3.9 -14 2 6 137.7 3.8 -14 4 24 192.3 4.1 -14 7 15 36.1 9.7 -14 10 10 36.5 9.3 -14 2 7 269.6 6.0 -14 4 25 211.9 4.5 -14 7 16 139.9 3.6 -14 10 11 315.6 4.1 -14 2 8 28.6 10.3 -14 4 26 44.3 13.2 -14 7 17 233.5 3.5 -14 10 12 241.2 3.5 -14 2 9 203.5 3.8 -14 4 27 200.9 4.0 -14 7 18 27.4 10.7 -14 10 13 129.9 3.4 -14 2 10 430.3 7.6 -14 5 1 217.5 5.4 -14 7 19 184.9 3.6 -14 10 14 73.7 5.0 -14 2 11 224.8 3.6 -14 5 2 280.5 4.7 -14 7 20 185.4 7.2 -14 10 15 148.8 3.6 -14 2 12 15.6 7.7 -14 5 3 177.3 5.1 -14 7 22 181.9 3.9 -14 10 16 82.5 5.3 -14 2 13 198.3 3.6 -14 5 4 245.4 4.0 -14 7 23 83.2 6.7 -14 10 17 101.9 4.1 -14 2 14 143.1 3.4 -14 5 5 182.5 4.1 -14 7 24 227.6 4.2 -14 10 18 156.0 4.8 -14 2 15 143.6 3.5 -14 5 6 186.7 3.4 -14 7 25 180.8 3.9 -14 10 19 223.9 5.4 -14 2 16 20.5 9.6 -14 5 7 133.4 3.6 -14 7 26 157.5 4.7 -14 10 20 112.3 5.7 WO 99/10379 PCT/GB98/02542 -58 -14 10 21 167.4 4.1 -14 13 18 130.3 8.5 -14 16 17 39.5 11.8 -14 19 21 99.2 4.4 -14 10 22 286.5 4.9 -14 13 19 146.1 3.8 -14 16 18 166.5 3.8 -14 19 22 48.7 15.1 -14 10 23 139.0 4.6 -14 13 20 257.8 3.9 -14 16 19 124.2 5.1 -14 20 1 118.4 5.1 -14 10 24 56.2 10.6 -14 13 21 119.7 6.2 -14 16 20 165.3 4.2 -14 20 2 25.9 10.7 -14 10 25 109.5 6.6 -14 13 22 47.7 11.4 -14 16 21 179.3 3.9 -14 20 3 15.6 7.7 -14 10 26 25.9 11.8 -14 13 23 30.9 11.8 -14 16 22 25.8 11.0 -14 20 4 208.1 4.3 -14 11 1 74.6 5.7 -14 13 24 204.4 4.1 -14 16 23 46.1 13.6 -14 20 5 135.0 3.3 -14 11 2 42.4 11.0 -14 13 25 166.2 3.9 -14 16 24 75.3 10.6 -14 20 6 67.9 6.4 -14 11 3 143.7 4.0 -14 14 1 74.6 5.2 -14 17 1 228.1 4.4 -14 20 7 112.4 3.3 -14 11 4 268.0 4.8 -14 14 2 210.1 3.6 -14 17 2 133.4 3.7 -14 20 8 44.4 8.6 -14 11 5 203.6 3.8 -14 14 3 140.6 3.6 -14 17 3 61.5 7.5 -14 20 9 224.8 4.2 -14 11 6 82.7 5.6 -14 14 4 114.8 10.4 -14 17 4 282.4 4.3 -14 20 10 78.9 5.6 -14 11 7 124.1 3.4 -14 14 5 196.7 3.4 -14 17 5 214.5 4.0 -14 20 11 203.4 3.5 -14 11 8 152.3 3.5 -14 14 6 125.5 4.7 -14 17 6 176.2 3.4 -14 20 13 270.8 10.4 -14 11 9 217.9 3.6 -14 14 7 271.1 6.1 -14 17 7 207.9 3.6 -14 20 14 156.4 4.0 -14 11 10 323.2 4.8 -14 14 8 221.7 4.1 -14 17 8 134.3 4.4 -14 20 15 102.7 4.7 -14 11 11 226.1 3.7 -14 14 9 356.5 5.0 -14 17 9 169.4 3.4 -14 20 16 144.5 5.0 -14 11 12 109.2 3.3 -14 14 10 135.6 3.1 -14 17 10 184.6 3.4 -14 20 17 33.3 11.3 -14 11 13 159.2 3.1 -14 14 11 148.1 3.9 -14 17 11 205.7 3.5 -14 20 18 116.7 5.1 -14 11 14 204.7 3.4 -14 14 12 169.6 3.2 -14 17 13 113.5 3.8 -14 20 19 177.3 3.5 -14 11 15 161.9 3.4 -14 14 13 86.9 4.3 -14 17 14 23.0 9.7 -14 20 20 74.8 7.2 -14 11 16 232.7 3.8 -14 14 14 162.1 3.4 -14 17 15 189.5 4.1 -14 20 21 84.9 8.5 -14 11 17 81.7 5.1 -14 14 15 77.4 5.1 -14 17 16 234.4 8.2 -14 20 22 25.9 11.1 -14 11 18 188.4 3.7 -14 14 16 53.1 9.5 -14 17 17 125.5 4.5 -14 21 1 100.4 4.6 -14 11 19 239.9 8.7 -14 14 18 174.2 13.2 -14 17 18 15.7 7.9 -14 21 2 180.5 4.2 -14 11 20 205.7 4.1 -14 14 19 321.7 5.3 -14 17 19 160.6 3.9 -14 21 3 91.7 4.0 -14 11 21 35.9 11.0 -14 14 20 75.4 5.4 -14 17 20 252.1 4.5 -14 21 4 123.1 4.2 -14 11 22 185.2 4.2 -14 14 21 115.6 5.3 -14 17 21 176.2 6.3 -14 21 5 88.2 6.8 -14 11 23 93.9 6.0 -14 14 22 188.1 5.1 -14 17 22 128.2 4.1 -14 21 6 55.3 5.8 -14 11 24 166.4 4.5 -14 14 23 40.7 13.0 -14 17 23 72.6 7.0 -14 21 7 177.2 3.7 -14 11 25 128.5 5.2 -14 14 24 65.7 9.0 -14 18 1 231.4 4.5 -14 21 8 191.9 3.4 -14 11 26 124.9 7.6 -14 14 25 90.1 7.2 -14 18 2 69.2 5.4 -14 21 9 101.4 5.4 -14 12 1 53.9 11.7 -14 15 1 39.2 10.7 -14 18 3 240.6 3.9 -14 21 10 169.3 3.2 -14 12 2 319.2 5.7 -14 15 2 74.6 6.5 -14 18 4 159.4 3.5 -14 21 11 141.3 4.1 -14 12 3 182.4 3.5 -14 15 3 22.8 9.5 -14 18 5 250.1 4.4 -14 21 12 238.8 8.8 -14 12 4 128.0 4.5 -14 15 4 54.5 17.9 -14 18 6 242.8 4.1 -14 21 13 199.5 3.8 -14 12 5 148.9 3.6 -14 15 5 69.3 4.4 -14 18 7 107.0 4.7 -14 21 14 135.0 4.5 -14 12 6 21.2 9.3 -14 15 6 28.4 10.9 -14 18 8 198.2 4.2 -14 21 15 159.8 3.6 -14 12 7 147.5 3.9 -14 15 7 317.8 4.7 -14 18 9 103.9 3.3 -14 21 16 96.4 4.6 -14 12 8 84.2 4.3 -14 15 8 19.5 9.1 -14 18 10 91.8 4.5 -14 21 17 53.4 7.7 -14 12 9 202.7 4.1 -14 15 9 62.1 5.5 -14 18 11 196.7 3.8 -14 21 18 106.1 5.3 -14 12 10 78.3 4.9 -14 15 10 204.9 3.5 -14 18 12 109.5 5.7 -14 21 19 102.9 5.7 -14 12 11 83.7 5.0 -14 15 11 97.0 4.5 -14 18 13 109.6 3.8 -14 21 20 82.2 5.7 -14 12 12 50.7 7.7 -14 15 12 61.2 5.2 -14 18 14 154.2 3.8 -14 21 21 111.6 7.2 -14 12 13 165.5 3.3 -14 15 13 203.6 4.1 -14 18 15 295.0 9.0 -14 22 1 90.4 6.1 -14 12 14 134.8 3.9 -14 15 14 134.9 3.5 -14 18 16 57.3 7.8 -14 22 2 206.6 3.8 -14 12 15 38.8 10.2 -14 15 15 60.6 7.0 -14 18 17 51.6 8.6 -14 22 3 44.9 11.1 -14 12 16 131.6 3.5 -14 15 16 126.3 3.8 -14 18 18 281.9 4.4 -14 22 4 131.4 4.4 -14 12 19 169.0 8.6 -14 15 17 337.4 6.7 -14 18 19 124.2 5.5 -14 22 5 174.7 3.6 -14 12 20 188.7 4.9 -14 15 18 228.9 4.2 -14 18 20 141.6 3.8 -14 22 6 195.3 3.7 -14 12 21 31.6 11.3 -14 15 19 84.2 6.9 -14 18 21 207.2 4.1 -14 22 7 77.6 4.6 -14 -12 22 86.6 5.8 -14 15 20 186.1 4.7 -14 18 22 119.2 8.1 -14 22 8 51.8 7.1 -14 12 23 136.8 4.5 -14 15 21 23.8 10.5 -14 18 23 100.3 7.0 -14 22 9 24.0 10.5 -14 12 24 58.7 10.7 -14 15 22 246.4 4.2 -14 19 1 97.6 5.5 -14 22 10 173.7 6.4 -14 12 25 101.8 5.5 -14 15 23 62.8 7.8 -14 19 2 46.6 9.6 -14 22 11 220.7 8.8 -14 13 1 157.8 4.3 -14 15 24 198.8 4.5 -14 19 3 155.4 4.0 -14 22 12 52.5 8.0 -14 13 2 214.0 3.5 -14 16 1 31.1 10.9 -14 19 4 101.2 5.1 -14 22 13 71.1 6.9 -14 13 3 208.2 4.4 -14 16 2 149.4 3.3 -14 19 5 60.1 8.4 -14 22 14 196.3 3.7 -14 13 4 28.5 9.5 -14 16 3 236.9 4.7 -14 19 6 297.2 4.6 -14 22 15 67.1 7.4 -14 13 5 33.0 10.8 -14 16 4 31.4 10.8 -14 19 7 83.8 4.8 -14 22 16 129.9 4.1 -14 13 6 28.5 9.3 -14 16 5 79.9 4.7 -14 19 8 148.6 3.4 -14 22 17 73.2 5.9 -14 13 7 78.0 5.2 -14 16 6 76.8 4.8 -14 19 9 20.5 9.4 -14 22 18 109.8 4.5 -14 13 8 142.8 3.6 -14 16 7 96.8 4.6 -14 19 10 160.2 3.3 -14 22 19 74.2 6.1 -14 13 9 70.7 5.6 -14 16 8 89.2 3.9 -14 19 12 27.3 10.3 -14 22 20 124.2 5.0 -14 13 10 14.0 6.9 -14 16 9 70.3 6.1 -14 19 13 145.7 4.8 -14 23 1 31.5 10.4 -14 13 11 299.5 5.2 -14 16 10 184.1 3.2 -14 19 14 198.8 9.1 -14 23 2 81.9 6.5 -14 13 12 37.8 9.1 -14 16 11 68.8 4.7 -14 19 15 164.9 3.9 -14 23 3 85.1 4.4 -14 13 13 157.5 3.4 -14 16 12 204.5 3.9 -14 19 16 208.1 4.5 -14 23 4 127.3 3.6 -14 13 14 71.8 5.7 -14 16 13 73.9 6.6 -14 19 17 108.7 4.5 -14 23 5 151.2 4.8 -14 13 15 189.2 3.3 -14 16 14 264.3 4.0 -14 19 18 128.7 4.0 -14 23 6 108.4 3.7 -14 13 16 90.9 5.4 -14 16 15 111.4 3.8 -14 19 19 188.0 4.9 -14 23 7 117.1 4.8 -14 13 17 298.1 4.3 -14 16 16 104.7 5.4 -14 19 20 122.9 5.8 -14 23 8 152.0 6.0 WO 99/10379 PCT/GB98/02542 -59 -14 23 9 358.9 7.1 -14 27 9 80.4 5.1 -13 0 12 69.6 6.9 -13 2 28 216.8 4.8 -14 23 10 152.8 3.9 -14 27 10 59.0 7.0 -13 0 13 238.6 5.3 -13 3 1 399.2 6.0 -14 23 11 55.9 7.8 -14 27 11 84.6 5.8 -13 0 14 73.4 8.9 -13 3 2 282.1 4.6 -14 23 12 275.0 4.6 -14 27 12 102.7 4.6 -13 0 15 27.9 15.4 -13 3 3 188.3 4.1 -14 23 13 142.0 4.3 -14 27 13 100.0 4.9 -13 0 16 127.9 4.4 -13 3 4 114.2 4.3 -14 23 14 43.6 8.9 -14 27 14 133.4 4.8 -13 0 17 12.4 9.0 -13 3 5 40.9 9.6 -14 23 15 78.7 5.2 -14 27 15 76.4 6.4 -13 0 18 110.3 8.0 -13 3 6 325.1 6.2 -14 23 16 88.9 4.7 -14 27 16 69.8 6.8 -13 0 19 212.8 5.1 -13 3 7 348.7 4.5 -14 23 17 65.6 7.0 -14 28 1 102.5 5.7 -13 0 20 138.7 5.8 -13 3 8 375.2 5.9 -14 23 18 63.7 8.7 -14 28 2 41.8 10.2 -13 0 21 26.6 16.8 -13 3 9 193.5 4.2 -14 23 19 167.4 5.6 -14 28 3 141.2 7.0 -13 0 22 12.7 9.2 -13 3 10 82.5 4.7 -14 24 2 82.9 7.5 -14 28 4 34.9 10.4 -13 0 23 111.4 16.5 -13 3 11 229.5 4.1 -14 24 3 66.7 8.9 -14 28 5 113.8 5.3 -13 0 24 124.9 5.5 -13 3 12 175.5 3.2 -14 24 4 49.7 9.4 -14 28 6 94.4 4.7 -13 0 25 101.8 7.7 -13 3 13 158.3 3.3 -14 24 5 100.7 5.9 -14 28 7 40.8 13.5 -13 0 26 135.7 5.7 -13 3 14 273.7 3.8 -14 24 6 238.3 9.6 -14 28 8 33.2 9.8 -13 0 27 28.8 18.0 -13 3 15 173.8 3.2 -14 24 7 210.8 5.3 -14 28 9 218.0 4.0 -13 0 28 128.7 7.7 -13 3 16 60.2 5.6 -14 24 8 17.1 8.4 -14 28 10 130.2 3.3 -13 1 1 209.8 3.9 -13 3 17 196.3 3.4 -14 24 9 27.9 10.4 -14 28 11 84.7 4.5 -13 1 2 140.6 7.2 -13 3 18 66.1 5.0 -14 24 10 98.0 4.1 -14 28 12 58.3 8.3 -13 1 3 238.7 3.9 -13 3 19 308.2 4.9 -14 24 11 38.5 9.1 -14 28 13 113.9 4.6 -13 1 4 115.9 3.6 -13 3 20 423.2 5.6 -14 24 12 20.7 9.1 -14 28 14 66.6 7.7 -13 1 5 259.6 4.0 -13 3 21 152.4 3.7 -14 24 13 15.4 7.8 -14 29 1 135.6 6.7 -13 1 6 417.0 6.1 -13 3 22 153.2 4.0 -14 24 14 71.2 7.3 -14 29 2 204.8 8.5 -13 1 7 120.5 7.0 -13 3 23 73.1 7.4 -14 24 15 48.1 11.0 -14 29 3 21.7 10.1 -13 1 8 289.4 4.7 -13 3 24 252.2 4.3 -14 24 16 72.4 6.3 -14 29 4 95.3 5.8 -13 1 9 272.4 5.3 -13 3 25 39.7 12.2 -14 24 17 144.9 4.4 -14 29 5 103.9 5.6 -13 1 10 73.9 5.0 -13 3 26 69.3 9.2 -14 24 18 69.6 7.5 -14 29 6 98.0 6.0 -13 1 11 90.9 5.2 -13 3 27 200.9 5.3 -14 24 19 159.4 4.9 -14 29 7 23.9 10.1 -13 1 12 146.8 3.5 -13 3 28 176.5 4.4 -14 25 1 222.3 9.8 -14 29 8 63.5 9.3 -13 1 13 180.1 3.5 -13 4 1 21.8 10.1 -14 25 2 252.6 15.2 -14 29 9 13.9 6.9 -13 1 14 225.1 3.5 -13 4 2 233.2 4.6 -14 25 3 163.1 19.9 -14 29 10 74.8 7.0 -13 1 15 206.2 3.6 -13 4 3 281.7 5.1 -14 25 4 186.7 6.3 -14 29 11 41.7 13.5 -13 1 16 367.1 5.7 -13 4 4 195.8 4.0 -14 25 5 148.9 5.9 -14 29 12 46.9 8.5 -13 1 17 160.0 3.6 -13 4 5 295.2 4.9 -14 25 6 176.8 4.0 -14 29 13 58.8 7.6 -13 1 18 126.8 3.4 -13 4 6 256.2 4.5 -14 25 7 45.0 9.4 -14 30 1 30.9 11.6 -13 1 19 136.4 7.1 -13 4 7 149.5 4.6 -14 25 8 113.4 4.9 -14 30 2 190.1 4.6 -13 1 20 217.7 3.7 -13 4 8 338.5 5.1 -14 25 9 147.4 3.5 -14 30 3 39.9 9.7 -13 1 21 122.1 4.1 -13 4 9 79.6 4.6 -14 25 10 124.0 3.9 -14 30 4 109.2 7.9 -13 1 22 163.6 3.8 -13 4 10 146.0 3.5 -14 25 11 80.8 5.4 -14 30 5 164.2 4.2 -13 1 23 129.9 10.4 -13 4 11 23.5 9.9 -14 25 12 130.7 4.8 -14 30 6 155.4 3.7 -13 1 24 153.9 3.7 -13 4 12 193.1 3.6 -14 25 13 114.3 4.8 -14 30 7 25.8 10.7 -13 1 25 190.7 4.7 -13 4 13 160.7 3.9 -14 25 14 64.2 6.7 -14 30 8 74.4 7.1 -13 1 26 108.4 5.9 -13 4 14 148.9 3.6 -14 25 15 71.2 5.7 -14 30 9 79.5 5.9 -13 1 27 44.2 14.2 -13 4 15 192.1 3.6 -14 25 16 46.8 9.8 -14 30 10 34.8 12.3 -13 1 28 58.9 11.2 -13 4 16 247.1 4.8 -14 25 17 100.1 6.0 -14 30 11 76.8 6.3 -13 2 1 115.7 6.9 -13 4 17 145.0 3.6 -14 25 18 67.2 10.3 -14 31 1 133.5 4.5 -13 2 2 145.7 6.8 -13 4 18 203.6 3.6 -14 26 1 71.9 11.8 -14 31 2 229.4 5.4 -13 2 3 154.2 4.1 -13 4 19 96.5 4.5 -14 26 2 214.9 4.6 -14 31 3 78.6 11.4 -13 2 4 116.3 4.2 -13 4 20 318.0 4.6 -14 26 3 82.7 5.4 -14 31 4 57.7 5.4 -13 2 5 120.7 4.0 -13 4 21 66.6 8.9 -14 26 4 123.8 4.4 -14 31 5 29.5 13.5 -13 2 6 139.6 5.0 -13 4 23 24.2 11.1 -14 -26 5 266.9 6.4 -14 31 6 49.5 10.4 -13 2 7 181.3 5.4 -13 4 24 206.0 4.2 -14 26 6 56.7 18.8 -14 31 7 46.1 10.8 -13 2 8 250.9 4.2 -13 4 25 136.4 4.0 -14 26 7 181.8 4.2 -14 31 8 132.0 3.7 -13 2 9 238.4 4.9 -13 4 26 108.6 5.9 -14 26 8 100.8 4.5 -14 31 9 23.6 10.6 -13 2 10 253.4 3.8 -13 4 27 95.5 6.9 -14 26 9 57.0 7.1 -14 32 1 26.4 11.2 -13 2 11 263.3 3.9 -13 4 28 255.6 4.8 -14 26 10 96.9 4.3 -14 32 2 141.5 5.0 -13 2 12 150.3 4.0 -13 5 1 232.1 4.6 -14 26 11 40.2 9.6 -14 32 3 110.8 4.9 -13 2 13 150.6 3.5 -13 5 2 182.5 3.8 -14 26 12 72.6 6.2 -14 32 4 138.8 5.0 -13 2 14 45.9 11.0 -13 5 3 87.8 5.8 -14 26 13 81.1 8.0 -14 32 5 142.5 6.8 -13 2 15 186.7 3.5 -13 5 4 159.4 5.7 -14 26 14 60.3 9.8 -14 32 6 107.9 5.0 -13 2 16 18.6 8.3 -13 5 5 219.5 5.3 -14 26 15 44.6 10.8 -13 0 1 441.3 9.3 -13 2 17 73.7 6.3 -13 5 6 70.6 6.2 -14 26 16 193.2 4.0 -13 0 2 181.2 9.4 -13 2 18 50.1 7.1 -13 5 7 64.2 7.5 -14 26 17 14.8 7.5 -13 0 3 34.0 17.0 -13 2 19 223.0 3.9 -13 5 8 17.4 8.5 -14 27 1 26.4 10.0 -13 0 4 99.8 5.2 -13 2 20 168.5 3.9 -13 5 9 166.5 3.4 -14 27 2 42.9 11.6 -13 0 5 379.3 7.8 -13 2 21 143.9 3.7 -13 5 10 176.2 3.7 -14 27 3 87.6 6.2 -13 0 6 38.1 16.9 -13 2 22 58.6 8.8 -13 5 11 152.6 3.6 -14 27 4 66.2 7.9 -13 0 7 277.8 5.6 -13 2 23 57.1 13.1 -13 5 12 67.9 6.8 -14 27 5 80.2 4.8 -13 0 8 16.3 11.2 -13 2 24 218.1 4.3 -13 5 13 194.9 3.3 -14 27 6 65.8 6.6 -13 0 9 120.4 7.8 -13 2 25 139.6 5.2 -13 5 14 194.1 3.4 -14 27 7 39.7 11.2 -13 0 10 76.7 6.6 -13 2 26 46.1 12.0 -13 5 15 87.3 3.8 -14 27 8 57.5 5.8 -13 0 11 163.5 8.8 -13 2 27 157.1 5.1 -13 5 16 68.5 5.6 WO 99/10379 PCT/GB98/02542 -60 -13 5 17 97.2 4.3 -13 8 5 130.9 4.5 -13 10 26 110.8 5.6 -13 13 18 198.2 3.5 -13 5 18 93.1 5.7 -13 8 6 85.3 5.1 -13 10 27 89.5 6.5 -13 13 19 198.5 4.2 -13 5 19 162.7 3.3 -13 8 7 87.4 4.2 -13 11 1 133.4 4.4 -13 13 20 184.7 7.3 -13 5 20 41.2 11.5 -13 8 8 152.4 3.8 -13 11 2 228.5 5.0 -13 13 21 152.3 3.9 -13 5 21 327.8 4.7 -13 8 9 281.6 4.2 -13 11 3 103.2 4.2 -13 13 22 18.9 9.0 -13 5 22 53.4 17.6 -13 8 10 151.0 3.2 -13 11 4 257.6 3.8 -13 13 23 88.3 6.9 -13 5 23 139.5 5.2 -13 8 11 116.8 3.6 -13 11 5 587.3 7.8 -13 13 24 260.0 4.9 -13 5 24 83.1 5.9 -13 8 12 163.6 3.2 -13 11 6 24.5 10.2 -13 13 25 126.6 6.0 -13 5 25 159.0 4.1 -13 8 13 34.2 9.7 -13 11 7 256.3 4.5 -13 13 26 30.8 11.8 -13 5 26 127.5 9.1 -13 8 14 158.7 3.3 -13 11 8 270.0 4.1 -13 14 1 252.8 3.9 -13 5 27 98.4 7.1 -13 8 15 41.4 12.1 -13 11 9 107.5 5.6 -13 14 2 220.4 4.6 -13 5 28 114.6 6.2 -13 8 16 41.4 11.0 -13 11 10 121.3 3.5 -13 14 3 152.8 3.4 -13 6 1 105.9 5.9 -13 8 17 203.3 3.6 -13 11 11 288.0 4.4 -13 14 4 185.9 3.9 -13 6 2 418.2 6.7 -13 8 18 65.2 6.8 -13 11 12 150.2 3.3 -13 14 5 107.6 3.9 -13 6 3 114.8 7.0 -13 8 19 19.6 9.4 -13 11 13 119.1 4.6 -13 14 6 38.1 8.9 -13 6 4 89.0 5.7 -13 8 20 141.1 3.7 -13 11 14 71.3 5.1 -13 14 7 82.1 4.4 -13 6 5 520.5 8.7 -13 8 21 22.8 10.1 -13 11 15 68.6 5.1 -13 14 8 117.6 3.4 -13 6 6 121.8 3.7 -13 8 22 257.1 11.1 -13 11 16 247.2 4.0 -13 14 9 118.3 4.4 -13 6 7 182.2 4.0 -13 8 23 93.9 8.1 -13 11 17 127.3 3.3 -13 14 10 133.8 3.2 -13 6 8 203.8 3.4 -13 8 24 127.1 4.8 -13 11 18 127.5 3.9 -13 14 11 101.0 3.8 -13 6 9 167.0 3.4 -13 8 25 91.9 7.1 -13 11 19 61.9 6.8 -13 14 12 123.4 4.3 -13 6 10 111.9 4.3 -13 8 27 125.2 4.5 -13 11 20 223.9 3.9 -13 14 13 82.5 7.3 -13 6 11 129.2 3.7 -13 9 1 346.6 6.2 -13 11 21 245.4 7.8 -13 14 14 63.0 7.4 -13 6 12 328.6 5.0 -13 9 2 138.9 3.5 -13 11 22 141.6 4.1 -13 14 15 258.5 3.9 -13 6 13 336.7 4.7 -13 9 3 132.1 4.8 -13 11 23 90.6 8.0 -13 14 16 172.8 3.3 -13 6 14 77.3 5.0 -13 9 4 28.7 9.5 -13 11 24 93.8 5.3 -13 14 17 112.0 4.4 -13 6 15 255.4 5.0 -13 9 5 74.4 5.3 -13 11 25 66.3 7.6 -13 14 18 170.7 3.5 -13 6 16 201.3 3.7 -13 9 6 277.3 4.2 -13 11 26 50.9 9.7 -13 14 20 218.2 4.2 -13 6 17 63.5 6.3 -13 9 7 124.8 4.1 -13 11 27 82.7 6.4 -13 14 21 17.8 8.6 -13 6 18 143.5 3.7 -13 9 8 208.9 3.6 -13 12 1 173.8 6.6 -13 14 22 74.0 6.5 -13 6 19 254.0 4.2 -13 9 9 198.4 3.4 -13 12 2 110.7 4.0 -13 14 23 181.4 4.0 -13 6 20 221.8 4.5 -13 9 10 182.5 3.3 -13 12 3 185.7 3.6 -13 14 24 143.6 5.1 -13 6 21 190.8 3.6 -13 9 11 211.8 3.3 -13 12 4 75.8 6.2 -13 14 25 84.1 6.9 -13 6 22 280.4 6.9 -13 9 12 57.1 6.8 -13 12 5 308.0 4.6 -13 14 26 239.7 4.9 -13 6 23 233.2 4.5 -13 9 13 280.4 4.4 -13 12 6 131.5 3.9 -13 15 1 137.4 3.3 -13 6 24 173.1 4.7 -13 9 14 191.8 4.9 -13 12 7 148.5 3.1 -13 15 2 297.8 5.5 -13 6 25 84.6 6.7 -13 9 15 224.3 3.6 -13 12 8 258.0 4.0 -13 15 3 194.1 3.5 -13 6 26 132.7 6.2 -13 9 16 44.2 8.2 -13 12 9 85.3 4.5 -13 15 4 210.4 5.0 -13 6 27 39.1 14.1 -13 9 17 182.0 3.6 -13 12 10 183.5 3.3 -13 15 5 64.7 7.2 -13 6 28 140.8 4.6 -13 9 18 202.9 3.6 -13 12 11 39.6 9.1 -13 15 6 134.3 3.1 -13 7 1 103.3 6.2 -13 9 19 152.5 7.9 -13 12 12 150.2 4.1 -13 15 7 172.9 3.2 -13 7 2 174.5 3.9 -13 9 20 162.1 3.6 -13 12 13 113.4 3.6 -13 15 8 145.8 3.2 -13 7 3 168.3 4.7 -13 9 22 116.7 5.4 -13 12 14 122.2 3.4 -13 15 9 98.0 3.7 -13 7 4 354.7 5.3 -13 9 23 151.5 5.0 -13 12 15 88.0 4.6 -13 15 10 137.9 3.5 -13 7 5 375.8 5.1 -13 9 24 110.6 5.8 -13 12 16 95.4 5.2 -13 15 11 211.3 3.5 -13 7 6 127.6 5.4 -13 9 25 68.4 7.9 -13 12 17 58.9 5.9 -13 15 12 104.5 3.7 -13 7 7 114.6 3.8 -13 9 26 189.9 4.0 -13 12 18 136.7 3.8 -13 15 13 67.6 5.1 -13 7 8 273.0 4.0 -13 9 27 256.9 4.7 -13 12 19 208.9 4.3 -13 15 14 38.6 10.7 -13 7 9 68.0 6.7 -13 10 1 107.8 4.1 -13 12 20 186.9 4.7 -13 15 15 138.0 3.3 -13 7 10 165.8 3.3 -13 10 3 93.1 6.3 -13 12 21 16.1 8.1 -13 15 16 139.9 3.5 -13 7 11 267.3 4.2 -13 10 4 124.1 3.4 -13 12 22 180.1 3.8 -13 15 17 77.7 6.7 -13-7 12 36.5 12.4 -13 10 5 133.6 3.4 -13 12 23 103.4 4.8 -13 15 18 15.8 7.8 -13 7 13 205.3 3.6 -13 10 6 100.2 5.3 -13 12 24 87.0 5.3 -13 15 19 312.1 11.9 -13 7 14 111.5 4.1 -13 10 7 238.9 3.7 -13 12 25 46.5 12.5 -13 15 20 174.2 3.9 -13 7 15 39.0 10.2 -13 10 8 51.2 6.8 -13 12 26 68.1 7.6 -13 15 21 165.7 3.5 -13 7 16 220.8 3.5 -13 10 9 100.4 3.8 -13 13 1 236.6 3.8 -13 15 22 27.2 11.6 -13 7 17 108.3 3.9 -13 10 10 191.6 3.3 -13 13 2 126.1 3.6 -13 15 23 167.0 3.9 -13 7 18 142.6 3.7 -13 10 11 214.2 4.0 -13 13 3 192.3 4.2 -13 15 24 186.0 4.2 -13 7 19 131.9 4.2 -13 10 12 221.3 3.5 -13 13 4 287.5 4.5 -13 15 25 115.7 4.9 -13 7 20 146.5 3.4 -13 10 13 80.4 5.5 -13 13 5 173.5 3.1 -13 16 1 108.3 7.2 -13 7 21 34.0 11.4 -13 10 14 156.0 3.3 -13 13 6 139.3 3.2 -13 16 2 271.0 5.0 -13 7 22 275.4 8.6 -13 10 15 248.2 3.8 -13 13 7 181.1 3.2 -13 16 3 115.9 4.5 -13 7 23 154.1 3.8 -13 10 16 134.4 3.4 -13 13 8 246.8 3.8 -13 16 4 21.8 8.9 -13 7 24 212.6 4.1 -13 10 17 302.3 4.2 -13 13 9 203.3 3.6 -13 16 5 41.7 8.2 -13 7 25 57.9 10.8 -13 10 18 70.6 5.4 -13 13 10 157.2 3.2 -13 16 6 51.3 11.4 -13 7 26 198.9 4.2 -13 10 19 44.3 10.5 -13 13 11 137.0 3.8 -13 16 7 252.2 3.8 -13 7 27 109.7 5.0 -13 10 20 296.4 4.7 -13 13 12 197.3 3.3 -13 16 8 134.9 3.9 -13 7 28 186.5 4.4 -13 10 21 258.0 6.1 -13 13 13 34.1 10.1 -13 16 9 73.6 5.9 -13 8 1 215.3 5.4 -13 10 22 125.9 5.1 -13 13 14 57.2 6.9 -13 16 10 23.9 9.0 -13 8 2 179.3 4.2 -13 10 23 153.0 4.4 -13 13 15 53.8 6.6 -13 16 11 170.5 3.8 -13 8 3 170.5 4.8 -13 10 24 230.8 5.3 -13 13 16 224.8 4.2 -13 16 12 43.4 8.5 -13 8 4 74.3 5.9 -13 10 25 156.4 4.0 -13 13 17 278.6 4.4 -13 16 13 67.2 4.8 WO 99/10379 PCT/GB98/02542 -61 -13 16 14 136.9 3.3 -13 19 13 61.2 5.6 -13 22 18 216.9 4.2 -13 26 10 166.3 3.5 -13 16 15 262.6 4.5 -13 19 14 133.5 3.3 -13 22 19 110.9 4.5 -13 26 11 154.2 3.4 -13 16 16 177.2 3.4 -13 19 15 117.7 4.0 -13 22 21 109.6 5.1 -13 26 12 139.3 3.3 -13 16 17 273.2 4.8 -13 19 16 81.0 8.3 -13 22 22 44.4 11.4 -13 26 13 122.2 4.2 -13 16 18 121.4 6.0 -13 19 17 14.4 7.2 -13 23 1 123.5 5.6 -13 26 14 179.1 4.2 -13 16 20 134.3 3.9 -13 19 18 101.7 5.2 -13 23 2 124.4 4.2 -13 26 15 108.1 4.0 -13 16 21 257.1 4.2 -13 19 19 154.8 3.8 -13 23 3 90.0 8.6 -13 26 16 113.4 4.6 -13 16 22 71.9 7.5 -13 19 20 63.7 9.2 -13 23 4 20.1 9.9 -13 26 17 133.5 4.2 -13 16 23 267.6 4.8 -13 19 21 78.8 6.8 -13 23 5 210.8 4.4 -13 26 18 71.7 6.3 -13 16 24 85.4 6.5 -13 19 22 253.9 4.5 -13 23 6 174.8 3.1 -13 26 19 64.5 7.3 -13 16 25 104.4 6.0 -13 19 23 138.5 4.2 -13 23 7 100.0 4.2 -13 27 2 243.1 13.3 -13 17 1 159.1 4.1 -13 19 24 55.3 9.0 -13 23 8 144.4 3.7 -13 27 3 137.2 12.1 -13 17 2 161.2 3.9 -13 20 1 250.2 4.6 -13 23 9 189.8 3.2 -13 27 4 130.4 5.7 -13 17 3 177.0 3.5 -13 20 2 76.7 4.8 -13 23 10 176.6 3.3 -13 27 5 245.9 5.1 -13 17 4 192.7 4.9 -13 20 3 70.4 4.6 -13 23 12 199.2 7.7 -13 27 6 109.7 5.1 -13 17 5 191.5 3.2 -13 20 4 106.7 3.9 -13 23 13 174.7 4.1 -13 27 7 259.9 3.9 -13 17 6 159.2 3.1 -13 20 5 138.8 3.8 -13 23 14 126.2 5.0 -13 27 8 27.6 9.6 -13 17 7 125.6 3.4 -13 20 6 82.8 4.4 -13 23 15 115.1 4.0 -13 27 9 72.9 6.0 -13 17 8 108.8 3.3 -13 20 7 158.4 3.1 -13 23 16 150.3 4.6 -13 27 10 45.6 6.9 -13 17 9 106.9 3.3 -13 20 8 74.1 5.5 -13 23 17 70.0 6.3 -13 27 11 92.1 4.0 -13 17 10 201.7 3.8 -13 20 9 150.3 3.3 -13 23 18 68.0 7.1 -13 27 12 196.6 3.6 -13 17 11 247.5 3.7 -13 20 10 139.6 3.2 -13 23 19 152.7 4.0 -13 27 13 109.9 4.2 -13 17 12 120.1 3.6 -13 20 11 153.8 3.9 -13 23 20 175.0 4.7 -13 27 14 136.8 4.0 -13 17 13 215.3 3.6 -13 20 12 232.3 4.0 -13 23 21 102.1 4.6 -13 27 15 137.0 3.7 -13 17 14 26.9 10.7 -13 20 13 45.3 7.0 -13 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24 14 41.1 9.0 -13 28 11 90.2 4.8 -13 18 3 100.0 3.9 -13 21 5 231.4 4.3 -13 24 15 223.2 4.1 -13 28 12 182.2 3.6 -13 18 4 175.7 5.0 -13 21 6 74.7 4.1 -13 24 16 143.5 3.9 -13 28 13 112.5 4.4 -13 18 5 304.1 5.0 -13 21 8 155.5 3.4 -13 24 17 104.3 4.4 -13 28 14 83.5 8.9 -13 18 6 169.1 3.6 -13 21 9 187.5 3.1 -13 24 18 48.9 10.2 -13 28 15 115.9 4.2 -13 18 7 161.9 3.6 -13 21 10 71.2 4.2 -13 24 19 41.1 11.7 -13 28 16 20.5 9.4 -13 18 8 59.0 7.6 -13 21 11 90.8 3.6 -13 24 20 59.8 9.7 -13 28 17 107.6 5.2 -13 18 9 139.9 3.0 -13 21 12 38.0 13.6 -13 25 1 25.8 9.5 -13 29 1 20.4 8.9 -13 18 10 132.1 3.2 -13 21 13 16.4 8.1 -13 25 2 107.6 4.8 -13 29 2 135.6 5.9 -13 18 11 245.8 3.8 -13 21 14 60.0 8.8 -13 25 3 81.4 5.4 -13 29 3 64.2 9.2 -13 18 12 143.7 3.8 -13 21 15 66.1 13.8 -13 25 4 120.6 3.5 -13 29 4 34.3 11.2 -13 18 13 21.4 9.1 -13 21 16 113.7 5.2 -13 25 5 96.2 5.8 -13 29 5 124.6 4.0 -13 18 14 59.1 6.7 -13 21 17 163.9 4.4 -13 25 6 64.8 7.7 -13 29 6 66.9 5.5 -13 18 15 167.6 3.5 -13 21 18 144.1 4.2 -13 25 7 25.3 9.1 -13 29 7 20.7 9.5 -13 -18 16 151.7 3.6 -13 21 19 16.0 8.0 -13 25 8 38.6 9.2 -13 29 8 126.0 3.2 -13 18 17 207.0 8.7 -13 21 20 22.9 10.3 -13 25 9 288.7 8.5 -13 29 9 84.5 4.0 -13 18 18 172.3 4.4 -13 21 21 101.1 4.6 -13 25 10 98.9 4.7 -13 29 10 225.8 3.8 -13 18 19 90.8 6.8 -13 21 22 35.0 10.9 -13 25 11 86.6 3.8 -13 29 11 191.1 3.4 -13 18 20 162.2 4.0 -13 22 1 194.2 5.2 -13 25 12 106.4 4.3 -13 29 12 102.5 4.1 -13 18 21 30.2 10.9 -13 22 2 110.7 3.4 -13 25 13 152.9 3.7 -13 29 13 172.5 3.5 -13 18 22 134.6 4.1 -13 22 3 109.0 4.4 -13 25 14 120.5 3.9 -13 29 14 71.8 5.6 -13 18 23 48.3 10.9 -13 22 4 15.2 7.2 -13 25 15 63.5 6.8 -13 29 15 117.5 4.0 -13 18 24 77.0 7.4 -13 22 5 192.0 5.0 -13 25 16 133.1 3.9 -13 30 1 69.6 11.5 -13 19 1 241.6 3.9 -13 22 6 145.0 3.0 -13 25 17 79.3 5.3 -13 30 2 181.6 5.4 -13 19 2 17.0 8.0 -13 22 7 161.6 3.1 -13 25 18 95.3 5.5 -13 30 3 135.3 6.2 -13 19 3 64.9 6.2 -13 22 8 130.8 3.7 -13 25 19 21.0 9.9 -13 30 4 19.8 9.8 -13 19 4 170.4 4.0 -13 22 9 225.6 4.0 -13 25 20 57.2 13.1 -13 30 5 29.4 10.9 -13 19 5 131.8 2.9 -13 22 10 195.5 3.4 -13 26 1 117.7 7.8 -13 30 6 184.9 8.4 -13 19 6 216.2 4.2 -13 22 11 77.4 5.0 -13 26 3 135.5 4.1 -13 30 7 60.1 7.9 -13 19 7 200.7 3.2 -13 22 12 83.3 4.3 -13 26 4 111.2 8.7 -13 30 8 123.0 4.5 -13 19 8 48.4 6.5 -13 22 13 194.1 3.9 -13 26 5 96.3 4.9 -13 30 9 90.5 5.3 -13 19 9 238.3 3.8 -13 22 14 146.5 13.9 -13 26 6 302.6 8.3 -13 30 10 128.2 3.2 -13 19 10 147.2 3.0 -13 22 15 67.0 7.0 -13 26 7 211.7 6.1 -13 30 11 35.6 13.2 -13 19 11 80.7 4.3 -13 22 16 157.3 3.5 -13 26 8 156.5 4.3 -13 30 12 217.5 3.7 -13 19 12 117.6 3.7 -13 22 17 29.6 11.0 -13 26 9 23.6 9.9 -13 30 13 22.7 9.8 WO 99/10379 PCT/GB98/02542 -62 -13 30 14 61.6 7.7 -12 1 6 600.5 8.8 -12 3 20 95.5 5.2 -12 6 6 232.2 5.0 -13 31 1 253.2 5.3 -12 1 7 45.5 10.2 -12 3 21 19.9 9.6 -12 6 7 147.1 5.5 -13 31 2 115.2 9.5 -12 1 8 193.1 3.5 -12 3 22 188.6 3.7 -12 6 8 202.6 3.6 -13 31 3 119.9 4.7 -12 1 9 155.5 6.0 -12 3 23 146.1 3.8 -12 6 9 379.7 5.7 -13 31 4 133.5 5.5 -12 1 10 79.8 5.5 -12 3 24 292.0 9.8 -12 6 10 51.8 8.3 -13 31 5 144.6 3.5 -12 1 11 75.2 4.7 -12 3 25 298.4 4.9 -12 6 11 327.7 4.6 -13 31 6 87.0 4.1 -12 1 12 255.8 4.3 -12 3 26 47.4 12.5 -12 6 12 216.3 3.6 -13 31 7 93.7 4.7 -12 1 13 80.8 4.9 -12 3 27 127.1 5.5 -12 6 13 170.2 3.3 -13 31 8 111.7 3.0 -12 1 14 121.5 5.7 -12 3 28 207.9 4.1 -12 6 14 89.6 6.3 -13 31 9 132.2 3.8 -12 1 15 18.4 8.8 -12 3 29 97.5 8.0 -12 6 15 130.4 3.6 -13 31 10 133.2 3.4 -12 1 16 78.8 4.8 -12 4 1 170.3 4.3 -12 6 16 132.2 3.6 -13 31 11 79.4 5.6 -12 1 17 229.5 3.6 -12 4 2 196.8 4.4 -12 6 17 67.7 6.2 -13 31 12 119.7 4.0 -12 1 18 166.6 3.2 -12 4 3 310.0 5.0 -12 6 18 199.4 3.4 -13 31 13 85.8 5.8 -12 1 19 245.7 4.0 -12 4 4 660.3 9.8 -12 6 19 174.6 3.2 -13 32 1 20.7 9.5 -12 1 20 128.2 4.0 -12 4 5 19.3 9.5 -12 6 20 264.2 4.3 -13 32 2 30.1 13.4 -12 1 21 100.7 7.0 -12 4 6 193.2 3.8 -12 6 21 21.5 9.8 -13 32 3 153.5 3.8 -12 1 22 191.2 3.6 -12 4 7 387.6 5.1 -12 6 22 207.0 3.7 -13 32 4 197.0 5.1 -12 1 23 106.4 5.2 -12 4 8 247.6 5.9 -12 6 23 386.8 5.5 -13 32 5 164.8 6.2 -12 1 24 204.4 7.6 -12 4 9 239.1 3.9 -12 6 24 120.4 6.8 -13 32 6 115.5 4.0 -12 1 25 154.5 4.7 -12 4 10 50.3 6.7 -12 6 25 134.3 4.7 -13 32 7 114.8 6.4 -12 1 26 158.3 4.2 -12 4 11 108.0 4.0 -12 6 26 330.3 5.2 -13 32 8 186.4 4.6 -12 1 27 77.5 12.4 -12 4 12 348.2 5.6 -12 6 27 88.0 6.1 -13 32 9 216.1 3.7 -12 1 28 141.4 4.0 -12 4 13 200.3 3.5 -12 6 28 57.3 13.0 -13 32 10 26.7 11.2 -12 1 29 22.7 10.9 -12 4 14 167.4 3.3 -12 6 29 59.0 14.2 -13 32 11 174.6 4.1 -12 2 1 431.3 8.1 -12 4 15 200.1 3.6 -12 7 1 452.5 7.1 -13 33 1 56.5 8.2 -12 2 2 114.4 8.6 -12 4 16 160.3 3.3 -12 7 2 229.2 4.8 -13 33 2 108.8 5.8 -12 2 3 92.2 6.6 -12 4 17 151.3 3.2 -12 7 3 192.4 3.9 -13 33 3 100.5 3.9 -12 2 4 353.7 4.6 -12 4 18 239.9 3.8 -12 7 4 151.9 3.6 -13 33 4 36.2 11.9 -12 2 5 262.0 4.1 -12 4 19 135.9 3.3 -12 7 5 248.6 4.4 -13 33 5 114.4 4.6 -12 2 6 75.9 10.1 -12 4 20 267.2 4.1 -12 7 6 146.8 3.7 -13 33 6 235.2 6.3 -12 2 7 406.7 7.7 -12 4 21 156.6 3.8 -12 7 7 240.4 4.3 -13 33 7 144.5 3.9 -12 2 8 225.7 3.9 -12 4 22 77.4 6.7 -12 7 8 205.4 3.6 -13 33 8 75.3 8.0 -12 2 9 220.3 4.0 -12 4 23 99.2 4.9 -12 7 9 216.5 3.6 -13 34 1 75.9 7.1 -12 2 10 120.2 6.6 -12 4 24 269.5 10.7 -12 7 10 158.0 3.6 -13 34 2 38.2 10.0 -12 2 11 76.2 4.4 -12 4 25 180.0 4.1 -12 7 11 20.7 9.2 -13 34 3 34.6 15.6 -12 2 12 188.0 3.9 -12 4 26 224.7 4.0 -12 7 12 291.5 4.8 -13 34 4 80.2 15.4 -12 2 13 98.0 4.5 -12 4 27 116.9 6.0 -12 7 13 275.5 4.6 -13 34 5 80.5 9.4 -12 2 14 44.1 8.8 -12 4 28 182.5 5.7 -12 7 14 168.9 3.3 -12 0 1 120.7 15.9 -12 2 15 523.8 7.4 -12 4 29 75.8 8.8 -12 7 15 207.6 3.7 -12 0 2 396.2 10.2 -12 2 16 22.5 9.5 -12 5 1 159.3 4.9 -12 7 16 157.3 4.9 -12 0 3 89.1 9.1 -12 2 17 100.4 7.4 -12 5 2 401.3 6.1 -12 7 17 109.4 3.6 -12 0 4 110.6 6.9 -12 2 18 63.1 5.1 -12 5 3 167.7 3.6 -12 7 18 201.7 3.6 -12 0 5 174.3 8.0 -12 2 19 154.8 3.8 -12 5 4 311.8 5.3 -12 7 19 93.6 4.4 -12 0 6 203.4 5.4 -12 2 20 115.2 4.6 -12 5 5 491.4 7.5 -12 7 20 128.8 3.4 -12 0 7 352.0 7.3 -12 2 21 90.6 6.1 -12 5 6 244.1 4.4 -12 7 21 195.1 3.5 -12 0 8 82.6 8.7 -12 2 22 176.6 3.6 -12 5 7 160.3 5.3 -12 7 22 41.0 11.4 -12 0 9 417.2 9.1 -12 2 23 15.7 7.8 -12 5 8 24.6 11.4 -12 7 24 69.5 8.6 -12 0 10 158.5 4.9 -12 2 24 209.2 8.0 -12 5 9 339.8 6.1 -12 7 25 20.1 9.5 -12 0 11 98.3 8.1 -12 2 25 166.2 4.8 -12 5 10 200.3 3.7 -12 7 26 71.2 6.9 -12 0 12 262.2 7.7 -12 2 26 99.7 10.9 -12 5 11 116.2 3.7 -12 7 27 224.2 4.3 -12 0 13 341.1 6.4 -12 2 27 188.1 4.8 -12 5 13 114.4 4.2 -12 7 28 138.7 6.5 -12-0 14 416.2 11.2 -12 2 28 52.8 10.7 -12 5 14 127.4 4.0 -12 7 29 160.5 4.8 -12 0 15 207.8 4.9 -12 2 29 242.7 4.7 -12 5 15 169.8 3.7 -12 8 1 302.6 4.8 -12 0 16 147.5 4.4 -12 3 1 225.4 8.6 -12 5 16 153.7 4.0 -12 8 2 258.5 4.3 -12 0 17 120.1 4.8 -12 3 2 376.9 5.8 -12 5 17 65.1 6.4 -12 8 3 142.9 3.4 -12 0 18 114.1 4.9 -12 3 3 385.9 5.5 -12 5 18 95.3 4.2 -12 8 4 158.7 3.8 -12 0 19 154.3 4.4 -12 3 4 231.2 3.9 -12 5 19 182.7 3.3 -12 8 5 457.2 6.6 -12 0 20 41.8 20.1 -12 3 5 146.7 3.7 -12 5 20 208.2 3.8 -12 8 6 184.5 3.5 -12 0 21 88.2 11.0 -12 3 6 18.7 9.0 -12 5 21 173.5 3.6 -12 8 7 164.9 3.6 -12 0 22 91.0 5.7 -12 3 7 111.0 7.1 -12 5 22 230.3 3.7 -12 8 8 356.7 5.5 -12 0 23 10.2 7.6 -12 3 8 155.8 3.5 -12 5 23 203.4 4.1 -12 8 9 103.0 4.6 -12 0 24 190.4 12.7 -12 3 9 147.6 3.6 -12 5 24 140.8 12.6 -12 8 10 393.2 6.1 -12 0 25 70.5 8.9 -12 3 10 314.5 4.5 -12 5 25 110.1 5.3 -12 8 11 171.4 4.9 -12 0 26 73.4 11.0 -12 3 11 276.8 4.5 -12 5 26 118.4 5.3 -12 8 12 269.1 4.0 -12 0 27 155.2 9.8 -12 3 12 214.9 3.5 -12 5 27 102.2 6.4 -12 8 13 131.9 3.6 -12 0 28 23.3 14.4 -12 3 13 126.9 3.8 -12 5 28 34.5 12.8 -12 8 14 257.0 3.9 -12 0 29 142.2 12.0 -12 3 14 225.3 3.7 -12 5 29 84.5 8.0 -12 8 15 152.0 3.3 -12 1 1 204.5 6.7 -12 3 15 215.2 3.7 -12 6 1 75.0 11.6 -12 8 16 335.7 5.4 -12 1 2 448.5 7.3 -12 3 16 235.6 5.5 -12 6 2 210.7 4.7 -12 8 17 54.9 7.4 -12 1 3 307.2 4.7 -12 3 17 170.2 3.4 -12 6 3 116.5 3.7 -12 8 18 166.1 3.3 -12 1 4 548.6 7.0 -12 3 18 164.9 3.4 -12 6 4 273.3 4.6 -12 8 19 99.9 5.5 -12 1 5 320.9 5.0 -12 3 19 42.1 8.7 -12 6 5 88.4 5.1 -12 8 20 243.1 3.9 WO 99/10379 PCT/GB98/02542 -63 -12 8 21 136.1 3.4 -12 11 8 147.1 3.4 -12 13 26 111.2 4.7 -12 16 17 204.9 3.6 -12 8 22 145.9 3.8 -12 11 9 323.6 4.8 -12 13 27 241.5 4.3 -12 16 18 100.1 4.2 -12 8 23 150.8 9.8 -12 11 10 177.4 3.8 -12 14 1 37.7 15.7 -12 16 19 103.3 4.1 -12 8 24 230.4 4.1 -12 11 11 364.1 5.1 -12 14 2 251.0 6.3 -12 16 20 292.8 6.6 -12 8 25 55.8 10.5 -12 11 12 121.1 3.3 -12 14 3 252.8 8.7 -12 16 21 53.3 7.5 -12 8 26 138.5 4.5 -12 11 13 297.4 4.5 -12 14 4 45.0 6.1 -12 16 22 102.5 4.8 -12 8 27 17.9 9.0 -12 11 14 121.3 3.4 -12 14 5 155.1 3.2 -12 16 23 66.2 10.2 -12 8 28 107.5 6.4 -12 11 15 235.9 4.5 -12 14 6 177.7 3.5 -12 16 24 313.7 5.3 -12 8 29 85.2 8.4 -12 11 16 214.3 3.4 -12 14 7 171.9 3.4 -12 16 25 160.6 4.6 -12 9 1 325.9 5.6 -12 11 17 80.9 4.5 -12 14 8 190.6 3.4 -12 16 26 106.4 6.6 -12 9 2 404.4 7.4 -12 11 18 211.3 5.5 -12 14 9 67.4 5.3 -12 17 1 76.9 5.0 -12 9 3 86.3 7.7 -12 11 19 15.4 7.5 -12 14 10 216.7 3.5 -12 17 2 86.3 4.4 -12 9 4 366.5 5.0 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-12 12 6 313.4 5.3 -12 14 24 160.2 3.9 -12 17 16 276.1 6.0 -12 9 18 316.8 4.7 -12 12 7 55.6 5.6 -12 14 25 102.3 5.0 -12 17 17 113.4 3.8 -12 9 19 166.5 3.4 -12 12 8 253.7 4.1 -12 14 26 267.4 5.6 -12 17 18 85.3 4.0 -12 9 20 260.0 3.9 -12 12 9 179.6 4.7 -12 14 27 87.1 6.9 -12 17 19 170.8 3.9 -12 9 21 130.2 3.4 -12 12 10 104.1 4.4 -12 15 1 265.4 4.5 -12 17 20 207.7 4.7 -12 9 22 174.6 3.6 -12 12 11 73.3 5.0 -12 15 2 137.5 4.1 -12 17 21 106.6 7.6 -12 9 23 242.6 7.8 -12 12 12 301.4 4.3 -12 15 3 96.6 3.7 -12 17 22 307.4 5.0 -12 9 24 154.6 3.9 -12 12 13 308.2 4.4 -12 15 4 219.3 4.2 -12 17 23 136.4 4.1 -12 9 25 251.9 4.4 -12 12 14 228.4 3.8 -12 15 5 181.3 3.3 -12 17 24 149.8 4.1 -12 9 26 153.6 4.2 -12 12 15 134.3 3.4 -12 15 6 120.5 5.1 -12 17 25 102.5 5.2 -12 9 27 311.9 5.0 -12 12 16 219.9 3.7 -12 15 7 122.2 3.1 -12 17 26 53.6 9.8 -12 9 28 169.3 5.1 -12 12 17 59.1 5.7 -12 15 8 146.6 2.9 -12 18 1 190.4 4.0 -12 10 1 181.5 4.5 -12 12 18 194.6 3.4 -12 15 9 26.8 10.7 -12 18 2 110.9 4.3 -12 10 2 62.2 8.4 -12 12 19 127.7 3.3 -12 15 10 241.4 3.6 -12 18 3 203.6 3.9 -12 10 3 323.0 7.8 -12 12 20 248.0 4.1 -12 15 11 57.3 5.6 -12 18 4 87.0 4.9 -12 10 4 60.8 6.7 -12 12 21 165.4 4.0 -12 15 12 46.9 6.7 -12 18 5 196.3 3.1 -12 10 5 156.0 3.4 -12 12 22 335.3 8.4 -12 15 13 52.0 5.5 -12 18 6 157.5 3.0 -12 10 6 72.8 5.8 -12 12 23 68.2 8.3 -12 15 14 292.3 4.2 -12 18 7 68.9 4.5 -12 10 7 82.3 6.1 -12 12 24 55.5 9.1 -12 15 15 208.4 3.9 -12 18 8 196.0 3.4 -12 10 8 322.3 4.9 -12 12 25 243.5 4.9 -12 15 16 350.3 5.1 -12 18 10 317.4 5.0 -12 10 9 117.8 3.6 -12 12 26 170.5 4.0 -12 15 17 157.2 3.3 -12 18 11 313.2 4.4 -12 10 10 199.6 3.4 -12 12 27 149.3 4.1 -12 15 18 58.3 7.7 -12 18 12 197.8 3.4 -12 10 11 147.3 3.5 -12 12 28 169.8 4.5 -12 15 19 83.6 4.7 -12 18 13 274.4 4.0 -12 10 12 106.2 3.6 -12 13 1 230.5 4.6 -12 15 20 81.6 5.6 -12 18 14 238.3 3.5 -12 10 13 109.1 4.1 -12 13 2 223.1 4.5 -12 15 21 97.4 8.1 -12 18 15 185.0 3.4 -12 10 14 61.7 6.4 -12 13 3 167.1 7.7 -12 15 22 140.5 4.6 -12 18 16 81.1 6.3 -12-10 15 179.3 3.3 -12 13 4 334.5 4.8 -12 15 23 76.2 6.8 -12 18 17 128.3 3.6 -12 10 16 113.6 3.6 -12 13 5 224.3 3.5 -12 15 24 38.0 12.2 -12 18 18 19.9 9.2 -12 10 17 119.6 6.0 -12 13 6 323.5 4.4 -12 15 25 126.1 4.1 -12 18 19 225.4 5.6 -12 10 18 180.0 3.3 -12 13 7 78.4 5.2 -12 15 26 105.3 6.5 -12 18 20 118.9 5.1 -12 10 19 92.5 5.2 -12 13 8 406.7 6.4 -12 15 27 381.1 6.6 -12 18 21 174.4 4.1 -12 10 20 119.9 4.2 -12 13 9 167.2 3.5 -12 16 1 303.2 5.6 -12 18 22 39.9 11.0 -12 10 21 229.0 3.8 -12 13 10 173.8 3.2 -12 16 2 299.7 5.3 -12 18 23 155.8 3.7 -12 10 22 57.2 10.7 -12 13 11 134.0 3.6 -12 16 3 152.0 4.4 -12 18 24 98.3 5.1 -12 10 23 26.0 12.1 -12 13 12 179.7 3.5 -12 16 4 182.4 3.7 -12 18 25 123.6 4.1 -12 10 24 149.4 3.9 -12 13 13 31.0 10.4 -12 16 5 174.3 3.3 -12 19 1 121.6 5.2 -12 10 25 76.7 5.8 -12 13 14 240.5 3.6 -12 16 6 65.0 5.4 -12 19 2 93.6 6.3 -12 10 26 139.5 4.8 -12 13 15 210.1 3.7 -12 16 7 89.2 3.8 -12 19 3 176.4 4.8 -12 10 27 119.5 6.5 -12 13 16 192.0 3.3 -12 16 8 249.0 3.7 -12 19 4 77.5 4.4 -12 10 28 195.7 4.4 -12 13 17 132.8 3.9 -12 16 9 16.2 7.3 -12 19 5 79.2 5.2 -12 11 1 560.2 10.1 -12 13 18 185.4 3.3 -12 16 10 274.0 4.4 -12 19 6 117.8 3.0 -12 11 2 103.6 8.3 -12 13 19 141.6 3.7 -12 16 11 138.0 3.6 -12 19 7 94.1 3.9 -12 11 3 416.2 8.2 -12 13 20 71.8 5.5 -12 16 12 143.5 3.9 -12 19 8 58.3 6.4 -12 11 4 109.3 3.8 -12 13 22 158.2 3.8 -12 16 13 72.1 6.1 -12 19 9 76.8 4.3 -12 11 5 340.5 5.8 -12 13 23 117.0 5.4 -12 16 14 180.9 3.6 -12 19 10 150.5 3.1 -12 11 6 241.5 4.6 -12 13 24 226.5 3.9 -12 16 15 77.5 4.9 -12 19 11 75.7 5.0 -12 11 7 53.1 6.4 -12 13 25 92.6 6.8 -12 16 16 205.8 3.6 -12 19 12 101.5 3.4 WO 99/10379 PCT/GB98/02542 -64 -12 19 13 64.4 5.8 -12 22 12 113.0 3.3 -12 25 17 222.9 4.1 -12 29 13 83.2 6.6 -12 19 14 94.5 3.6 -12 22 13 75.8 4.6 -12 25 18 79.0 6.6 -12 29 14 163.7 3.6 -12 19 15 86.9 3.9 -12 22 14 82.8 4.3 -12 25 19 78.5 5.1 -12 29 15 155.6 3.5 -12 19 16 78.7 4.2 -12 22 15 127.9 3.7 -12 25 20 60.0 9.7 -12 29 16 33.4 11.7 -12 19 17 114.5 4.0 -12 22 16 246.4 13.0 -12 25 21 94.1 4.7 -12 29 17 19.5 9.6 -12 19 18 59.2 17.0 -12 22 17 144.6 3.6 -12 26 1 91.7 3.1 -12 30 1 122.0 4.4 -12 19 19 48.9 9.3 -12 22 18 165.8 3.5 -12 26 2 38.2 7.8 -12 30 2 100.8 5.9 -12 19 20 96.7 4.6 -12 22 19 142.3 3.9 -12 26 3 34.4 11.0 -12 30 3 89.3 4.9 -12 19 21 178.4 4.2 -12 22 20 240.9 4.0 -12 26 4 137.4 5.5 -12 30 4 139.7 4.0 -12 19 22 162.5 4.5 -12 22 21 123.5 4.2 -12 26 5 101.7 5.0 -12 30 5 100.6 4.2 -12 19 23 193.8 3.8 -12 22 22 252.7 4.3 -12 26 6 179.8 3.7 -12 30 6 27.0 13.1 -12 19 24 38.3 12.0 -12 22 23 47.4 10.2 -12 26 7 116.8 2.7 -12 30 7 66.8 7.6 -12 19 25 135.3 4.4 -12 23 1 181.5 4.0 -12 26 8 104.1 3.2 -12 30 8 96.4 3.9 -12 20 1 154.9 3.6 -12 23 2 80.6 4.1 -12 26 9 100.0 4.3 -12 30 9 166.9 3.1 -12 20 2 170.7 4.5 -12 23 3 145.2 3.8 -12 26 10 45.5 10.7 -12 30 10 145.6 3.4 -12 20 3 169.5 3.6 -12 23 4 95.5 6.9 -12 26 11 202.6 8.7 -12 30 11 165.2 4.0 -12 20 4 58.0 8.0 -12 23 5 261.7 5.6 -12 26 12 174.1 3.8 -12 30 12 65.6 5.1 -12 20 5 181.5 3.3 -12 23 6 130.2 3.3 -12 26 13 102.1 3.7 -12 30 13 158.6 3.5 -12 20 6 142.2 3.0 -12 23 7 217.9 3.6 -12 26 14 266.5 4.0 -12 30 14 146.4 4.0 -12 20 7 123.4 2.9 -12 23 8 228.9 3.4 -12 26 15 221.8 3.9 -12 30 15 221.5 3.7 -12 20 8 240.5 3.8 -12 23 9 210.2 3.4 -12 26 16 79.1 5.0 -12 30 16 46.3 11.0 -12 20 9 77.4 4.6 -12 23 10 161.9 3.0 -12 26 17 218.5 4.0 -12 31 1 174.7 4.1 -12 20 10 88.8 3.4 -12 23 11 70.1 4.4 -12 26 18 69.2 6.1 -12 31 2 215.6 6.0 -12 20 11 88.1 3.6 -12 23 12 117.0 4.0 -12 26 19 89.8 5.6 -12 31 3 122.4 6.4 -12 20 12 193.7 3.2 -12 23 13 104.2 4.0 -12 26 20 105.3 4.3 -12 31 4 198.5 6.6 -12 20 13 219.8 3.5 -12 23 14 86.7 4.7 -12 27 1 106.0 4.3 -12 31 5 78.7 5.2 -12 20 14 244.8 3.8 -12 23 15 335.2 9.1 -12 27 2 68.0 6.2 -12 31 6 214.1 4.1 -12 20 15 97.8 4.1 -12 23 16 21.0 9.2 -12 27 3 307.3 4.6 -12 31 7 88.1 5.9 -12 20 16 232.4 3.6 -12 23 17 264.6 4.4 -12 27 4 111.2 3.0 -12 31 8 118.1 4.2 -12 20 17 233.2 3.9 -12 23 18 296.6 4.2 -12 27 5 196.4 3.7 -12 31 9 41.1 10.4 -12 20 18 140.3 5.1 -12 23 19 110.8 4.1 -12 27 6 305.2 6.5 -12 31 10 106.5 5.0 -12 20 19 78.1 6.2 -12 23 20 206.7 4.4 -12 27 8 32.2 12.8 -12 31 11 122.7 4.0 -12 20 20 135.1 4.1 -12 23 21 124.4 4.0 -12 27 9 226.6 6.6 -12 31 12 84.4 4.0 -12 20 21 51.3 11.8 -12 23 22 62.3 6.8 -12 27 10 148.8 3.2 -12 31 13 177.2 3.7 -12 20 22 179.0 3.9 -12 23 23 125.2 4.5 -12 27 11 103.4 4.4 -12 31 14 83.4 4.3 -12 20 23 137.2 4.9 -12 24 1 66.7 13.7 -12 27 12 103.3 4.1 -12 31 15 128.8 4.3 -12 20 24 119.0 4.4 -12 24 2 177.2 3.9 -12 27 13 140.8 3.3 -12 32 1 207.0 4.3 -12 21 1 167.4 4.5 -12 24 3 56.9 5.4 -12 27 14 117.6 4.1 -12 32 2 166.1 4.0 -12 21 2 30.6 10.1 -12 24 4 135.5 3.3 -12 27 15 73.1 5.7 -12 32 3 34.1 13.4 -12 21 3 256.3 4.6 -12 24 5 100.8 3.2 -12 27 16 119.4 4.5 -12 32 4 173.1 5.4 -12 21 4 23.3 9.9 -12 24 6 155.8 4.2 -12 27 17 200.7 3.8 -12 32 5 149.5 5.1 -12 21 5 96.4 3.8 -12 24 7 45.1 6.7 -12 27 18 87.2 5.2 -12 32 6 125.9 3.2 -12 21 6 322.8 4.9 -12 24 8 114.5 3.1 -12 27 19 31.1 9.9 -12 32 7 104.2 3.0 -12 21 7 99.0 3.7 -12 24 9 106.2 3.5 -12 28 1 197.4 5.5 -12 32 8 64.1 5.6 -12 21 8 61.6 5.5 -12 24 10 142.4 3.3 -12 28 2 92.2 8.6 -12 32 9 122.6 3.2 -12 21 9 144.5 3.0 -12 24 11 89.3 3.7 -12 28 3 42.3 11.0 -12 32 10 179.1 3.4 -12 21 10 118.7 3.2 -12 24 12 91.2 4.7 -12 28 4 87.3 6.1 -12 32 11 72.1 4.5 -12 21 11 11.7 5.9 -12 24 13 16.7 8.3 -12 28 5 125.2 12.4 -12 32 12 133.4 5.0 -12 21 12 107.8 4.2 -12 24 14 140.7 8.4 -12 28 6 192.6 6.3 -12 32 13 128.9 3.8 -12 21 13 154.4 3.1 -12 24 15 87.6 5.1 -12 28 7 187.2 4.5 -12 33 1 38.9 11.2 -12 21 14 125.6 3.6 -12 24 16 285.6 4.2 -12 28 9 74.8 4.3 -12 33 2 166.4 6.9 -12 .21 15 210.6 3.6 -12 24 17 317.9 4.8 -12 28 10 290.3 4.2 -12 33 3 43.5 13.6 -12 21 16 19.5 8.7 -12 24 18 28.7 10.8 -12 28 11 138.0 4.1 -12 33 4 91.6 7.8 -12 21 17 202.8 7.5 -12 24 19 79.9 5.6 -12 28 12 129.9 3.9 -12 33 5 69.0 5.9 -12 21 18 163.9 4.0 -12 24 20 96.5 4.5 -12 28 13 142.2 3.9 -12 33 6 150.9 4.1 -12 21 19 141.3 4.1 -12 24 21 130.4 5.0 -12 28 14 152.0 3.2 -12 33 7 76.0 5.7 -12 21 20 159.2 3.6 -12 25 1 49.5 12.7 -12 28 15 202.6 4.0 -12 33 8 110.6 5.4 -12 21 21 44.1 11.6 -12 25 2 177.6 3.7 -12 28 16 103.4 4.3 -12 33 9 194.3 3.7 -12 21 22 107.9 6.6 -12 25 3 108.7 5.0 -12 28 17 81.3 5.1 -12 33 10 49.6 6.9 -12 21 23 65.0 6.1 -12 25 4 61.7 6.8 -12 28 18 138.1 4.1 -12 33 11 97.7 3.9 -12 21 24 93.8 5.1 -12 25 5 225.7 3.5 -12 29 1 85.1 7.8 -12 33 12 69.7 8.3 -12 22 1 385.9 11.2 -12 25 6 40.3 7.9 -12 29 2 100.5 6.7 -12 34 1 46.0 9.2 -12 22 2 102.9 3.9 -12 25 7 32.4 8.4 -12 29 3 76.5 18.3 -12 34 2 131.2 3.3 -12 22 3 116.5 3.5 -12 25 8 48.6 7.2 -12 29 4 195.3 5.9 -12 34 3 73.0 6.3 -12 22 4 68.5 4.5 -12 25 9 80.8 4.1 -12 29 5 242.9 5.6 -12 34 4 120.0 6.9 -12 22 5 230.5 4.1 -12 25 10 161.1 3.1 -12 29 6 56.5 5.8 -12 34 5 101.7 6.7 -12 22 6 75.2 4.2 -12 25 11 112.8 3.5 -12 29 7 15.4 7.6 -12 34 6 14.2 6.9 -12 22 7 71.8 4.4 -12 25 12 279.4 7.3 -12 29 8 83.3 4.3 -12 34 7 61.1 4.8 -12 22 8 106.3 3.1 -12 25 13 161.6 4.4 -12 29 9 282.3 4.6 -12 34 8 86.4 6.9 -12 22 9 81.8 3.7 -12 25 14 128.3 4.0 -12 29 10 210.2 3.4 -12 34 9 30.1 11.1 -12 22 10 26.9 10.1 -12 25 15 20.2 9.3 -12 29 11 182.1 3.4 -12 35 1 103.4 6.6 -12 22 11 47.7 6.6 -12 25 16 39.5 9.4 -12 29 12 205.6 4.2 -12 35 2 188.1 5.9 WO 99/10379 PCT/GB98/02542 -65 -12 35 3 134.9 4.2 -11 2 15 386.8 5.9 -11 4 29 29.5 12.8 -11 7 13 93.3 4.6 -12 35 4 36.1 15.3 -11 2 16 478.0 7.6 -11 4 30 115.2 6.2 -11 7 14 135.4 3.2 -12 35 5 92.2 7.4 -11 2 17 190.8 4.2 -11 5 1 205.8 6.7 -11 7 15 166.2 3.4 -12 35 6 48.5 8.7 -11 2 18 42.1 8.1 -11 5 3 620.3 21.3 -11 7 16 49.4 8.0 -11 0 1 122.2 7.4 -11 2 19 197.2 3.5 -11 5 4 642.1 14.6 -11 7 17 140.4 3.9 -11 0 3 287.6 5.7 -11 2 20 253.2 3.8 -11 5 5 323.3 10.9 -11 7 18 126.0 3.7 -11 0 4 31.4 15.0 -11 2 21 78.8 8.8 -11 5 6 483.9 12.0 -11 7 19 58.2 6.8 -11 0 5 477.2 10.1 -11 2 22 155.3 3.5 -11 5 7 457.3 6.4 -11 7 20 96.1 3.8 -11 0 6 284.7 15.8 -11 2 23 216.2 3.8 -11 5 8 108.1 4.5 -11 7 21 133.2 3.7 -11 0 8 94.2 14.1 -11 2 24 71.6 9.3 -11 5 9 159.3 3.9 -11 7 22 149.6 3.5 -11 0 9 312.3 6.2 -11 2 25 111.1 14.9 -11 5 10 100.4 5.2 -11 7 23 154.8 5.8 -11 0 10 218.8 5.4 -11 2 26 157.5 7.1 -11 5 11 458.0 8.0 -11 7 24 352.9 5.3 -11 0 11 143.9 5.1 -11 2 27 172.3 4.4 -11 5 12 182.5 4.4 -11 7 25 77.4 7.7 -11 0 12 169.1 4.9 -11 2 28 38.6 13.3 -11 5 13 406.0 6.0 -11 7 26 16.6 8.1 -11 0 13 208.8 6.1 -11 2 29 211.8 4.4 -11 5 14 168.2 3.8 -11 7 27 48.0 11.3 -11 0 14 393.3 7.6 -11 2 30 29.5 13.7 -11 5 15 135.1 3.1 -11 7 28 45.1 12.6 -11 0 15 144.8 6.1 -11 3 1 793.2 11.2 -11 5 16 50.5 8.1 -11 7 29 91.3 6.4 -11 0 16 11.1 8.2 -11 3 3 478.8 6.4 -11 5 17 94.4 4.2 -11 7 30 213.9 5.7 -11 0 17 84.8 12.9 -11 3 4 215.4 4.5 -11 5 18 124.2 3.4 -11 8 1 163.7 6.5 -11 0 18 104.8 8.1 -11 3 6 720.2 13.8 -11 5 19 129.8 3.3 -11 8 2 26.6 10.9 -11 0 19 158.2 4.5 -11 3 7 393.1 6.5 -11 5 20 107.5 4.5 -11 8 3 187.6 3.9 -11 0 20 257.3 5.7 -11 3 8 453.3 5.6 -11 5 21 255.6 3.7 -11 8 4 67.2 5.9 -11 0 21 74.8 14.4 -11 3 9 187.2 3.5 -11 5 22 181.0 3.6 -11 8 5 481.6 7.0 -11 0 22 293.8 6.4 -11 3 10 533.6 8.6 -11 5 23 382.6 5.2 -11 8 6 502.0 7.7 -11 0 23 29.9 14.4 -11 3 11 415.2 6.4 -11 5 24 131.2 4.5 -11 8 7 412.0 6.5 -11 0 24 165.0 8.4 -11 3 12 190.1 3.6 -11 5 25 291.2 11.1 -11 8 8 247.7 4.2 -11 0 25 151.7 15.3 -11 3 13 124.5 3.3 -11 5 26 71.8 7.1 -11 8 9 188.0 3.6 -11 0 27 21.0 13.9 -11 3 14 156.0 5.4 -11 5 27 142.5 4.8 -11 8 10 198.8 3.6 -11 0 28 35.4 17.4 -11 3 15 258.0 4.1 -11 5 28 147.3 5.5 -11 8 11 62.5 5.3 -11 0 29 73.9 15.3 -11 3 16 608.7 9.6 -11 5 29 85.4 6.9 -11 8 12 120.7 3.8 -11 0 30 74.7 14.2 -11 3 17 199.8 3.5 -11 5 30 121.1 5.7 -11 8 13 226.2 3.7 -11 1 1 392.4 5.9 -11 3 18 162.4 3.3 -11 6 1 420.0 18.3 -11 8 14 184.8 3.5 -11 1 3 27.9 11.5 -11 3 19 86.6 4.1 -11 6 2 231.2 17.5 -11 8 15 273.5 4.0 -11 1 4 171.6 4.0 -11 3 20 86.0 4.7 -11 6 3 287.9 12.1 -11 8 16 437.3 6.2 -11 1 5 94.2 8.6 -11 3 21 224.3 4.0 -11 6 4 428.5 11.7 -11 8 17 136.8 4.1 -11 1 6 506.9 14.1 -11 3 22 112.9 4.1 -11 6 5 394.5 12.6 -11 8 18 123.3 3.6 -11 1 7 185.2 25.1 -11 3 23 93.5 4.6 -11 6 6 204.2 4.4 -11 8 19 375.1 5.9 -11 1 8 505.7 6.3 -11 3 24 84.1 6.8 -11 6 7 221.3 3.6 -11 8 20 63.5 5.3 -11 1 9 120.5 4.8 -11 3 25 495.7 7.5 -11 6 8 174.8 3.9 -11 8 21 423.6 6.1 -11 1 10 346.9 5.6 -11 3 26 287.6 4.5 -11 6 9 33.5 9.5 -11 8 22 156.6 4.0 -11 1 11 233.8 3.9 -11 3 27 30.1 12.4 -11 6 10 287.8 4.3 -11 8 23 214.9 3.8 -11 1 12 386.7 5.0 -11 3 28 45.7 12.6 -11 6 11 218.8 3.7 -11 8 24 40.2 15.0 -11 1 13 626.3 8.7 -11 3 29 96.8 6.0 -11 6 12 446.4 7.4 -11 8 25 43.6 11.7 -11 1 14 173.0 4.1 -11 3 30 90.8 7.8 -11 6 13 279.7 4.5 -11 8 26 154.4 5.0 -11 1 15 114.2 3.9 -11 4 1 460.3 7.8 -11 6 14 404.3 6.1 -11 8 27 255.9 4.6 -11 1 16 250.5 4.1 -11 4 2 27.2 12.3 -11 6 15 228.9 4.0 -11 8 28 100.1 5.5 -11 1 17 180.4 3.3 -11 4 3 53.7 16.9 -11 6 16 310.3 4.1 -11 8 29 135.7 4.5 -11 1 18 110.2 3.3 -11 4 4 220.9 8.1 -11 6 17 105.9 3.8 -11 9 1 535.1 11.4 -11 1 19 181.4 3.3 -11 4 5 437.7 8.7 -11 6 18 222.6 3.4 -11 9 2 45.8 11.5 -11 1 20 265.0 4.2 -11 4 6 242.2 16.0 -11 6 19 19.2 9.0 -11 9 3 117.5 3.3 -11 1 21 96.1 7.7 -11 4 7 160.3 3.9 -11 6 20 157.8 3.4 -11 9 4 260.9 4.7 -11 .1 22 213.0 4.2 -11 4 8 502.5 6.2 -11 6 21 148.0 4.1 -11 9 5 222.3 3.9 -11 1 23 192.6 3.6 -11 4 9 167.2 3.3 -11 6 22 221.5 3.8 -11 9 6 221.0 4.1 -11 1 24 85.7 7.7 -11 4 10 415.7 6.1 -11 6 23 117.2 4.4 -11 9 7 31.6 11.8 -11 1 25 89.5 18.7 -11 4 11 246.5 4.0 -11 6 24 210.9 3.9 -11 9 8 28.7 10.6 -11 1 26 51.3 12.1 -11 4 12 293.8 4.6 -11 6 25 85.8 12.4 -11 9 9 568.8 8.1 -11 1 27 225.6 4.8 -11 4 13 378.2 5.8 -11 6 26 384.5 5.8 -11 9 10 112.3 3.9 -11 1 28 155.8 4.3 -11 4 14 186.7 3.8 -11 6 27 391.3 6.2 -11 9 11 155.3 3.1 -11 1 29 129.3 6.6 -11 4 15 119.3 3.4 -11 6 28 152.9 5.6 -11 9 12 321.3 4.8 -11 1 30 36.1 14.7 -11 4 16 109.8 4.5 -11 6 29 150.9 4.3 -11 9 13 101.8 3.9 -11 2 1 70.0 12.7 -11 4 17 245.9 4.5 -11 6 30 39.1 13.4 -11 9 14 243.9 4.1 -11 2 3 38.3 10.0 -11 4 18 101.8 3.6 -11 7 1 516.7 15.5 -11 9 15 160.5 3.3 -11 2 4 419.7 6.4 -11 4 19 228.0 4.0 -11 7 2 187.9 17.6 -11 9 16 121.2 3.3 -11 2 5 492.1 14.9 -11 4 20 183.0 3.4 -11 7 3 224.5 12.3 -11 9 17 75.8 5.6 -11 2 6 444.8 14.0 -11 4 21 157.8 3.8 -11 7 5 181.9 3.6 -11 9 18 84.4 4.2 -11 2 8 28.5 13.0 -11 4 22 98.6 4.4 -11 7 6 273.0 4.5 -11 9 19 122.6 3.7 -11 2 9 150.4 3.6 -11 4 23 129.0 4.5 -11 7 7 404.0 6.4 -11 9 20 122.8 3.6 -11 2 10 388.5 6.1 -11 4 24 81.8 7.2 -11 7 8 192.6 3.6 -11 9 21 148.1 3.9 -11 2 11 228.4 3.9 -11 4 25 251.5 9.1 -11 7 9 38.2 9.0 -11 9 22 190.1 4.6 -11 2 12 306.9 5.0 -11 4 26 238.7 4.5 -11 7 10 182.8 3.9 -11 9 23 252.2 4.2 -11 2 13 108.2 5.4 -11 4 27 24.9 10.9 -11 7 11 320.1 4.2 -11 9 24 282.1 6.1 -11 2 14 104.5 5.7 -11 4 28 238.5 4.8 -11 7 12 497.4 7.9 -11 9 25 380.8 7.2 WO 99/10379 PCT/GB98/02542 -66 -11 9 26 272.9 4.4 -ll 12 11 179.8 3.1 -11 14 28 76.8 6.6 -11 17 17 281.2 3.9 -11 9 27 112.8 6.2 -11 12 12 402.7 5.1 -11 15 1 286.8 4.9 -11 17 18 100.9 3.9 -11 9 28 212.0 4.2 -11 12 13 89.9 6.3 -11 15 2 114.5 3.3 -11 17 19 91.0 4.5 -11 9 29 155.6 5.0 -11 12 14 295.0 4.4 -11 15 3 145.5 3.1 -11 17 20 82.3 4.9 -11l 10 1 475.1 6.7 -11 12 15 127.2 5.3 -11 15 4 242.8 3.9 -11 17 21 196.6 7.7 -11 10 2 395.8 6.4 -11 12 16 352.0 5.5 -11 15 5 276.3 4.2 -11 17 22 85.7 7.3 -11 10 3 676.8 10.7 -11 12 17 205.4 3.6 -11 15 6 117.1 4.0 -11 17 23 137.2 3.7 -11 10 4 228.7 4.9 -11 12 18 191.4 3.2 -11 15 7 184.0 3.2 -11 17 24 54.0 9.8 -11 10 5 325.8 4.7 -11 12 19 109.2 4.0 -11 15 8 279.4 4.2 -11 17 25 133.9 4.0 -11 10 6 273.0 5.0 -11 12 20 123.4 3.4 -11 15 9 139.5 3.8 -11 17 26 104.5 6.6 -11 10 7 220.6 3.9 -11 12 21 77.6 6.1 -11 15 10 339.5 5.0 -11 17 27 35.1 12.5 -11 10 8 375.6 5.7 -11 12 22 120.6 4.1 -11 15 11 206.7 3.3 -11 18 1 103.6 9.2 -11 10 9 339.5 5.0 -11 12 23 86.8 19.8 -11 15 12 378.2 5.1 -11 18 2 178.9 3.2 -11 10 10 94.8 5.5 -11 12 24 86.5 5.9 -11 15 13 394.6 5.8 -11 18 3 228.3 3.7 -11 10 11 157.1 3.0 -11 12 25 105.5 5.5 -11 15 14 262.5 4.2 -11 18 4 35.7 11.6 -11 10 12 206.8 3.6 -11 12 26 259.2 4.7 -11 15 15 72.1 4.8 -11 18 5 230.7 4.0 -11 10 13 48.2 7.9 -11 12 27 151.5 4.9 -11 15 16 59.9 6.2 -11 18 6 48.0 6.7 -11 10 14 46.7 7.2 -11 12 28 63.0 8.4 -11 15 17 178.6 3.3 -11 18 7 159.3 2.9 -11 10 15 74.3 5.0 -11 12 29 28.4 12.3 -11 15 18 102.2 4.0 -11 18 8 11.3 5.7 -11 10 16 122.1 3.9 -11 13 1 348.6 5.2 -11 15 19 124.5 3.2 -11 18 9 143.8 3.1 -11 10 17 118.6 3.9 -11 13 2 214.7 4.3 -11 15 20 130.5 3.8 -11 18 10 44.4 6.1 -11 10 18 172.2 3.3 -11 13 3 365.2 6.7 -11 15 21 206.5 4.6 -11 18 11 236.2 3.7 -11 10 19 112.4 4.4 -11 13 4 77.0 4.5 -11 15 22 204.3 7.0 -11 18 12 324.5 4.8 -11 10 20 98.2 6.1 -11 13 5 72.6 5.0 -11 15 23 96.9 5.3 -11 18 13 43.6 10.3 -11 10 21 21.9 9.7 -11 13 6 260.0 4.5 -11 15 24 195.6 3.7 -11 18 14 122.1 4.1 -11 10 22 69.0 7.1 -11 13 7 93.3 4.8 -11 15 25 110.3 5.2 -11 18 15 137.1 3.6 -11 10 23 150.7 3.6 -11 13 8 355.4 6.2 -11 15 26 157.5 5.9 -11 18 16 189.1 3.4 -11 10 24 312.3 8.2 -11 13 9 219.2 3.4 -11 15 27 261.7 4.6 -11 18 17 169.0 3.2 -11 10 25 108.7 4.9 -11 13 10 21.3 9.1 -11 15 28 117.0 5.4 -11 18 18 82.4 4.6 -11 10 26 89.1 6.3 -11 13 11 146.1 3.1 -11 16 1 186.0 4.0 -11 18 19 156.6 3.2 -11 10 27 211.0 4.2 -11 13 12 405.9 5.8 -11 16 2 164.8 3.5 -11 18 20 78.6 6.0 -11 10 28 174.6 3.9 -11 13 13 214.6 3.9 -11 16 3 194.2 4.0 -11 18 21 164.7 4.5 -11 10 29 32.2 13.7 -11 13 14 155.7 3.4 -11 16 4 315.2 5.3 -11 18 22 59.3 7.3 -11 11 1 601.5 8.9 -11 13 15 259.9 5.6 -11 16 5 238.7 3.7 -11 18 23 239.8 4.1 -11 11 2 100.6 6.4 -11 13 16 156.4 3.2 -11 16 6 207.2 3.5 -11 18 24 121.0 4.2 -11 11 3 231.5 4.6 -11 13 17 92.4 4.1 -11 16 7 113.3 3.0 -11 18 25 20.5 9.5 -11 11 4 24.2 9.4 -11 13 18 97.8 3.6 -11 16 8 156.6 3.1 -11 18 26 151.5 4.9 -11 11 5 358.1 5.8 -11 13 19 240.6 3.7 -11 16 9 132.5 3.6 -11 19 1 196.5 3.8 -11 11 6 254.5 4.3 -11 13 20 248.4 4.9 -11 16 10 304.6 5.4 -11 19 2 183.7 4.7 -11 11 7 145.6 3.9 -11 13 21 23.7 10.0 -11 16 11 70.8 4.2 -11 19 3 247.4 5.4 -11 11 8 323.1 5.3 -11 13 22 198.4 3.8 -11 16 12 122.4 3.2 -11 19 4 65.8 5.0 -11 11 9 225.3 3.7 -11 13 23 257.8 7.2 -11 16 13 86.4 5.6 -11 19 5 292.7 4.5 -11 11 10 380.5 5.5 -11 13 24 247.1 4.2 -11 16 14 132.9 3.6 -11 19 6 132.0 3.4 -11 11 11 164.0 3.3 -11 13 25 127.1 4.0 -11 16 15 59.6 5.4 -11 19 7 215.8 3.6 -11 11 12 289.6 4.6 -11 13 26 152.1 4.6 -11 16 16 145.2 3.5 -11 19 8 59.3 5.2 -11 11 13 61.1 5.9 -11 13 27 245.1 5.0 -11 16 17 80.2 4.8 -11 19 9 74.9 3.7 -11 11 14 314.7 4.7 -11 13 28 161.3 4.2 -11 16 18 156.7 3.3 -11 19 10 235.0 3.4 -11 11 15 95.6 4.1 -11 14 1 201.8 4.7 -11 16 19 305.2 4.5 -11 19 11 253.5 3.9 -11 11 16 134.7 3.4 -11 14 2 332.9 5.9 -11 16 20 139.2 3.2 -11 19 12 315.9 4.1 -11 11 17 104.9 3.4 -11 14 3 115.8 4.1 -11 16 21 200.2 4.0 -11 19 13 132.2 2.9 -11 11 18 147.6 3.5 -11 14 4 96.1 4.0 -11 16 22 172.3 4.2 -11 19 14 103.3 3.4 -11 11 19 149.1 3.1 -11 14 5 135.5 3.3 -11 16 23 191.3 3.9 -11 19 15 135.0 3.0 -11 11 20 159.7 3.3 -11 14 6 212.4 3.8 -11 16 24 107.6 5.4 -11 19 16 80.9 4.4 -11 11 21 116.5 4.0 -11 14 7 225.3 3.9 -11 16 25 172.2 4.3 -11 19 17 139.5 3.5 -11 11 22 276.1 5.0 -11 14 8 206.4 3.4 -11 16 26 124.6 4.4 -11 19 18 77.9 5.4 -11 11 23 15.5 7.8 -11 14 9 260.3 3.9 -11 16 27 186.2 4.1 -11 19 19 79.6 5.4 -11 11 24 42.7 15.4 -11 14 10 155.5 3.0 -11 17 1 295.2 4.5 -11 19 20 182.2 7.3 -11 11 25 196.8 4.0 -11 14 11 361.2 5.0 -11 17 2 124.8 3.5 -11 19 21 152.7 4.1 -11 11 26 138.8 5.6 -11 14 12 381.6 5.6 -11 17 3 143.2 3.3 -11 19 22 120.2 4.9 -11 11 27 204.7 4.7 -11 14 13 186.5 3.4 -11 17 4 142.2 3.6 -11 19 23 100.4 5.2 -11 11 28 222.9 4.1 -11 14 14 216.5 3.6 -11 17 5 210.1 3.3 -11 19 24 189.4 4.7 -11 11 29 41.3 12.1 -11 14 15 15.1 7.3 -11 17 6 183.8 3.2 -11 19 26 166.8 4.9 -11 12 1 37.3 10.0 -11 14 16 282.3 4.1 -11 17 7 268.2 3.7 -11 20 1 62.4 8.1 -11 12 2 455.4 6.8 -11 14 17 257.5 3.8 -11 17 8 347.0 4.9 -11 20 2 247.2 4.9 -11 12 3 400.0 6.2 -11 14 18 110.1 3.6 -11 17 9 337.2 5.0 -11 20 3 125.4 3.2 -11 12 4 36.3 9.1 -11 14 19 73.0 5.7 -11 17 10 161.7 3.0 -11 20 4 134.5 4.4 -11 12 5 281.1 4.2 -11 14 20 112.9 5.0 -11 17 11 139.3 3.0 -11 20 5 127.3 3.4 -11 12 6 577.6 7.8 -11 14 21 55.9 6.6 -11 17 12 175.0 3.0 -11 20 6 104.9 3.6 -11 12 7 101.8 5.1 -11 14 24 88.1 6.1 -11 17 13 123.6 3.0 -11 20 7 134.5 2.9 -11 12 8 79.0 5.8 -11 14 25 44.4 10.4 -11 17 14 119.6 3.4 -11 20 8 172.2 3.3 -11 12 9 324.4 5.2 -11 14 26 214.7 4.0 -11 17 15 88.8 4.0 -11 20 9 306.3 4.2 -11 12 10 217.6 3.6 -11 14 27 275.2 4.7 -11 17 16 263.8 3.8 -11 20 10 57.6 4.7 WO 99/10379 PCT/GB98/02542 -67 -11 20 11 160.0 2.8 -11 23 10 199.4 3.0 -11 26 13 126.6 7.7 -11 30 5 155.0 8.9 -11 20 12 102.1 3.2 -11 23 11 213.2 3.5 -11 26 14 137.5 4.2 -11 30 6 103.3 5.7 -11 20 13 155.7 3.1 -11 23 12 89.9 4.1 -11 26 15 270.4 4.0 -11 30 7 50.2 6.3 -11 20 14 224.5 3.2 -11 23 13 170.4 3.2 -11 26 16 70.3 6.2 -11 30 8 109.5 3.1 -11 20 15 163.4 5.1 -11 23 14 203.7 3.4 -11 26 17 105.2 5.5 -11 30 9 211.9 3.5 -11 20 16 234.1 3.5 -11 23 15 57.7 6.9 -11 26 18 170.3 3.3 -11 30 10 65.3 6.0 -11 20 17 123.9 3.2 -11 23 16 112.5 3.8 -11 26 19 125.6 3.8 -11 30 11 174.0 3.7 -11 20 18 285.0 4.2 -11 23 17 173.5 8.0 -11 26 20 104.5 4.4 -11 30 12 17.8 8.4 -11 20 19 178.6 11.4 -11 23 18 51.2 9.3 -11 26 21 33.2 11.2 -11 30 13 13.1 6.5 -11 20 20 135.2 4.1 -11 23 19 102.1 4.8 -11 26 22 50.7 10.8 -11 30 14 107.2 3.8 -11 20 21 32.5 10.6 -11 23 20 214.9 3.8 -11 27 1 253.4 4.5 -11 30 15 62.6 7.0 -11 20 22 116.4 3.8 -11 23 21 15.5 7.7 -11 27 2 34.9 12.8 -11 30 16 64.8 5.8 -11 20 23 20.2 9.4 -11 23 22 116.1 4.4 -11 27 3 104.4 4.2 -11 30 17 77.1 5.1 -11 20 24 65.8 6.7 -11 23 23 107.3 4.8 -11 27 4 263.4 4.2 -11 30 18 47.9 12.4 -11 20 25 81.1 6.1 -11 23 24 117.0 4.4 -11 27 5 31.7 11.2 -11 31 1 13.8 7.0 -11 21 1 192.5 3.3 -11 24 1 102.8 3.1 -11 27 6 97.6 3.4 -11 31 2 191.7 5.0 -11 21 2 85.1 4.0 -11 24 2 65.8 4.2 -11 27 7 178.4 2.9 -11 31 3 56.8 11.3 -11 21 3 93.9 6.7 -11 24 3 276.1 5.1 -11 27 8 61.8 5.4 -11 31 5 63.7 5.5 -11 21 4 179.9 3.1 -11 24 4 83.0 3.8 -11 27 9 227.0 3.3 -11 31 6 100.6 9.1 -11 21 5 131.1 3.3 -11 24 5 19.2 8.5 -11 27 10 158.0 2.9 -11 31 7 229.4 4.1 -11 21 6 67.7 4.4 -11 24 6 210.7 3.6 -11 27 11 208.8 3.7 -11 31 8 59.8 4.8 -11 21 7 136.8 2.8 -11 24 7 232.2 3.4 -11 27 12 251.0 6.7 -11 31 9 210.2 3.4 -11 21 8 119.5 2.8 -11 24 8 40.0 7.4 -11 27 13 167.4 3.4 -11 31 10 71.1 5.5 -11 21 9 307.4 4.5 -11 24 9 93.8 3.5 -11 27 14 199.9 3.6 -11 31 11 138.3 3.4 -11 21 10 187.7 3.3 -11 24 10 59.2 5.1 -11 27 15 140.1 3.2 -11 31 12 123.6 3.5 -11 21 11 65.5 3.8 -11 24 11 188.7 3.1 -11 27 16 248.6 4.1 -11 31 13 168.6 4.1 -11 21 12 56.5 5.9 -11 24 12 104.7 3.1 -11 27 17 219.1 3.8 -11 31 14 201.6 3.8 -11 21 13 329.1 4.9 -11 24 13 189.7 3.3 -11 27 18 85.0 5.6 -11 31 15 57.5 7.1 -11 21 14 142.6 3.1 -11 24 14 114.9 3.6 -11 27 19 222.8 5.2 -11 31 16 129.2 3.6 -11 21 15 56.9 5.3 -11 24 15 75.6 5.6 -11 27 20 98.8 4.3 -11 31 17 61.2 8.0 -11 21 16 162.9 3.3 -11 24 16 132.4 11.0 -11 27 21 116.0 6.3 -11 32 1 220.8 5.4 -11 21 17 158.3 3.9 -11 24 17 199.5 4.0 -11 28 1 102.7 2.8 -11 32 2 53.0 11.6 -11 21 18 167.0 4.2 -11 24 18 66.9 5.6 -11 28 2 207.0 4.0 -11 32 3 75.4 10.6 -11 21 20 169.3 3.7 -11 24 19 171.0 3.5 -11 28 3 211.6 3.6 -11 32 4 111.8 3.2 -11 21 21 82.9 5.7 -11 24 20 16.1 7.9 -11 28 4 89.8 7.3 -11 32 5 119.0 3.8 -11 21 22 28.2 11.7 -11 24 21 176.5 3.7 -11 28 5 91.1 4.8 -11 32 6 108.7 4.8 -11 21 23 164.2 4.3 -11 24 22 137.2 3.9 -11 28 6 135.0 4.1 -11 32 7 99.5 5.1 -11 21 24 68.1 6.4 -11 24 23 132.8 3.8 -11 28 7 111.1 3.7 -11 32 8 47.9 6.7 -11 21 25 116.3 4.5 -11 25 1 108.4 5.6 -11 28 8 98.0 3.2 -11 32 9 35.9 9.1 -11 22 1 113.8 3.8 -11 25 2 108.5 3.1 -11 28 9 15.5 7.6 -11 32 10 153.6 3.2 -11 22 2 228.6 3.6 -11 25 3 155.5 3.5 -11 28 10 289.4 7.0 -11 32 11 58.7 5.0 -11 22 3 130.3 3.6 -11 25 4 162.7 4.9 -11 28 11 95.3 4.6 -11 32 12 114.2 4.2 -11 22 4 206.3 3.4 -11 25 5 388.8 6.0 -11 28 12 176.2 3.3 -11 32 13 134.8 3.6 -11 22 5 35.1 6.9 -11 25 6 356.7 5.0 -11 28 13 101.9 4.1 -11 32 14 204.6 3.7 -11 22 6 60.1 4.6 -11 25 7 134.3 2.9 -11 28 14 158.5 3.7 -11 32 15 33.0 9.5 -11 22 7 172.9 2.9 -11 25 8 158.4 3.5 -11 28 15 206.4 3.7 -11 33 1 97.6 6.5 -11 22 8 145.1 3.5 -11 25 9 85.7 3.3 -11 28 16 80.9 5.9 -11 33 2 75.1 9.0 -11 22 9 187.7 2.9 -11 25 10 42.0 6.9 -11 28 17 93.0 4.3 -11 33 3 188.8 3.6 -11 22 10 359.4 5.5 -11 25 11 79.7 5.4 -11 28 18 176.1 3.8 -11 33 4 135.2 7.0 -11 22 11 108.7 4.3 -11 25 12 136.9 2.9 -11 28 19 210.9 4.4 -11 33 5 58.7 10.7 -11 22 12 231.5 3.7 -11 25 13 238.1 4.1 -11 28 20 75.9 7.3 -11 33 6 53.4 12.1 -11 .22 13 35.4 8.5 -11 25 14 203.1 4.3 -11 29 1 156.4 3.0 -11 33 7 41.6 8.3 -11 22 14 170.1 3.0 -11 25 15 79.7 9.4 -11 29 2 183.4 4.0 -11 33 8 103.7 3.4 -11 22 15 160.1 3.3 -11 25 16 84.7 4.1 -11 29 3 64.0 5.3 -11 33 9 68.8 4.1 -11 22 16 60.9 5.7 -11 25 17 112.7 4.0 -11 29 5 191.1 4.0 -11 33 10 103.6 3.8 -11 22 17 189.6 4.3 -11 25 18 65.8 8.5 -11 29 6 88.8 5.6 -11 33 11 54.6 6.0 -11 22 18 134.5 4.9 -11 25 19 85.7 4.5 -11 29 7 132.3 6.6 -11 33 12 62.8 5.5 -11 22 19 39.4 11.1 -11 25 20 56.4 7.9 -11 29 8 225.4 7.3 -11 33 13 51.7 7.2 -11 22 20 82.0 5.6 -11 25 21 170.6 4.3 -11 29 9 53.4 5.8 -11 33 14 14.6 7.3 -11 22 21 231.5 4.8 -11 25 22 81.8 4.7 -11 29 10 127.2 3.1 -11 34 1 85.7 4.3 -11 22 22 159.4 3.7 -11 26 1 102.3 4.9 -11 29 11 92.2 4.0 -11 34 2 84.4 5.1 -11 22 23 38.9 10.5 -11 26 2 141.7 4.8 -11 29 12 112.3 3.4 -11 34 3 106.1 5.4 -11 22 24 147.9 3.7 -11 26 3 96.6 6.2 -11 29 13 130.3 4.0 -11 34 4 118.1 6.1 -11 23 1 232.2 4.3 -11 26 4 396.7 6.4 -11 29 14 58.8 6.9 -11 34 5 80.7 7.4 -11 23 2 141.8 5.1 -11 26 5 151.5 3.5 -11 29 15 189.6 3.4 -11 34 6 30.7 12.6 -11 23 3 71.4 4.5 -11 26 6 131.1 2.7 -11 29 16 234.4 3.6 -11 34 7 90.8 3.9 -11 23 4 196.9 7.1 -11 26 7 245.9 3.4 -11 29 17 39.1 10.1 -11 34 8 49.2 7.6 -11 23 5 97.0 3.1 -11 26 8 140.6 4.0 -11 29 18 118.8 3.8 -11 34 9 60.2 5.2 -11 23 6 120.7 3.4 -11 26 9 115.0 2.9 -11 29 19 91.3 6.0 -11 34 10 70.4 5.4 -11 23 7 12.7 6.3 -11 26 10 60.2 5.5 -11 30 1 248.5 10.5 -11 34 11 98.4 3.5 -11 23 8 213.2 3.4 -11 26 11 148.3 3.6 -11 30 3 264.4 12.2 -11 34 12 75.4 5.9 -11 23 9 170.4 3.1 -11 26 12 104.7 3.7 -11 30 4 227.5 7.4 -11 35 1 108.7 5.8 WO 99/10379 PCT/GB98/02542 -68 -11 35 2 91.4 5.8 -10 1 26 224.2 11.8 -10 4 5 603.4 8.7 -10 6 16 116.6 3.6 -11 35 3 119.2 4.3 -10 1 27 106.1 6.8 -10 4 6 563.7 9.0 -10 6 17 175.3 3.5 -11 35 4 190.9 5.6 -10 1 28 207.8 4.3 -10 4 7 500.2 7.1 -10 6 18 127.3 3.9 -11 35 5 207.0 6.2 -10 1 29 181.6 4.4 -10 4 8 399.4 6.4 -10 6 19 289.8 4.2 -11 35 6 160.3 4.6 -10 1 30 62.8 9.1 -10 4 9 228.5 10.2 -10 6 20 311.1 4.3 -11 35 7 84.0 10.1 -10 1 31 75.3 7.1 -10 4 10 38.1 15.1 -10 6 21 186.0 3.4 -11 35 8 96.7 7.4 -10 2 1 342.6 5.1 -10 4 11 105.6 4.0 -10 6 22 57.8 6.8 -11 35 9 40.4 10.0 -10 2 2 346.1 4.4 -10 4 12 623.4 9.6 -10 6 23 22.8 10.2 -11 35 10 170.2 4.1 -10 2 3 366.3 5.2 -10 4 13 137.7 3.9 -10 6 24 80.4 6.2 -11 36 1 67.1 13.6 -10 2 4 584.4 7.7 -10 4 14 171.0 3.4 -10 6 25 296.7 4.7 -11 36 2 178.1 3.6 -10 2 5 239.9 3.8 -10 4 15 230.3 3.7 -10 6 26 199.5 7.6 -11 36 3 87.5 7.9 -10 2 6 661.1 8.0 -10 4 16 153.3 3.5 -10 6 27 304.2 5.4 -11 36 4 131.5 5.4 -10 2 7 296.7 4.6 -10 4 17 198.6 3.4 -10 6 28 149.4 4.8 -11 36 5 92.1 6.6 -10 2 8 507.6 6.7 -10 4 18 174.0 3.5 -10 6 29 144.7 4.6 -11 36 6 47.3 13.1 -10 2 9 570.6 10.2 -10 4 19 391.3 5.0 -10 6 30 129.8 5.5 -11 36 7 19.9 9.7 -10 2 10 739.5 12.7 -10 4 20 135.5 3.6 -10 6 31 69.7 8.9 -10 0 1 44.0 17.9 -10 2 11 707.2 11.3 -10 4 21 179.9 4.0 -10 7 1 84.0 5.7 -10 0 2 438.6 8.4 -10 2 12 431.8 6.4 -10 4 22 79.0 7.5 -10 7 2 231.3 4.6 -10 0 3 477.7 8.8 -10 2 13 188.3 4.4 -10 4 23 193.9 4.0 -10 7 3 333.8 4.8 -10 0 4 173.5 4.4 -10 2 14 185.6 3.6 -10 4 24 48.1 9.1 -10 7 4 363.6 5.2 -10 0 5 206.3 4.8 -10 2 15 239.0 3.7 -10 4 25 200.0 3.9 -10 7 5 94.5 7.1 -10 0 6 108.3 6.2 -10 2 16 176.9 3.6 -10 4 26 224.4 6.7 -10 7 6 318.1 4.7 -10 0 7 278.3 6.5 -10 2 17 299.2 4.2 -10 4 27 153.5 4.1 -10 7 7 625.7 7.8 -10 0 8 395.5 7.5 -10 2 18 145.6 3.7 -10 4 28 111.6 6.0 -10 7 8 556.0 10.1 -10 0 9 200.0 4.9 -10 2 19 291.9 3.9 -10 4 29 76.1 7.5 -10 7 9 179.6 3.6 -10 0 10 294.9 10.5 -10 2 20 57.2 7.2 -10 4 30 135.3 5.8 -10 7 10 188.5 3.3 -10 0 11 126.3 4.5 -10 2 21 407.5 6.1 -10 5 1 216.3 3.4 -10 7 11 61.0 6.3 -10 0 12 121.1 11.4 -10 2 22 77.1 6.0 -10 5 2 263.0 4.0 -10 7 12 115.7 4.1 -10 0 13 216.5 7.4 -10 2 23 219.0 3.9 -10 5 3 194.6 3.8 -10 7 13 299.7 5.0 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12 80.0 6.1 -9 34 10 178.3 3.1 -8 0 23 334.2 6.5 -9 27 6 89.3 3.0 -9 30 13 66.1 4.8 -9 34 11 184.2 3.3 -8 0 24 12.4 9.0 -9 27 7 105.0 3.0 -9 30 14 150.1 3.3 -9 34 12 101.9 3.6 -8 0 25 199.9 5.2 -9 27 8 45.2 5.1 -9 30 15 128.1 3.3 -9 34 13 161.4 3.6 -8 0 26 311.3 8.1 -9 27 9 184.9 3.4 -9 30 16 33.0 10.2 -9 34 14 17.4 8.5 -8 0 27 421.6 9.3 -9 27 10 29.0 8.3 -9 30 17 59.6 6.8 -9 34 15 19.3 8.4 -8 0 28 225.6 16.7 -9 27 11 94.6 3.5 -9 30 18 130.9 3.4 -9 34 16 68.2 6.4 -8 0 29 31.0 15.9 -9 27 12 88.3 3.6 -9 30 19 132.6 3.8 -9 35 1 45.2 10.2 -8 0 30 94.5 11.1 -9 27 13 111.4 3.3 -9 30 20 195.8 4.5 -9 35 2 121.1 4.6 -8 0 31 94.9 12.0 -9 27 14 27.5 9.2 -9 31 1 21.2 9.6 -9 35 3 36.0 13.2 -8 0 32 103.3 9.2 -9 27 15 195.7 3.9 -9 31 2 87.4 5.4 -9 35 4 66.8 7.7 -8 1 2 248.4 4.0 -9 27 16 143.7 6.7 -9 31 3 102.3 4.7 -9 35 5 125.0 6.8 -8 1 3 413.9 5.1 -9 27 17 191.1 3.4 -9 31 4 271.9 4.9 -9 35 6 45.8 10.6 -8 1 4 457.2 5.9 -9 27 18 138.4 3.3 -9 31 5 20.6 10.2 -9 35 7 95.9 4.2 -8 1 5 245.8 3.4 -9 27 19 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15 729.0 11.7 -9 29 17 163.9 3.4 -9 33 11 131.4 3.0 -8 0 6 492.6 9.1 -8 2 16 158.3 3.7 -9 29 18 89.1 4.9 -9 33 12 52.9 6.4 -8 0 7 161.8 4.0 -8 2 17 248.4 4.2 -9 29 19 27.8 9.3 -9 33 13 295.5 4.6 -8 0 9 1075.9 20.9 -8 2 18 211.3 3.7 -9 29 20 202.0 3.3 -9 33 14 78.7 4.6 -8 0 10 24.4 13.5 -8 2 19 105.6 5.8 -9 29 21 144.3 3.3 -9 33 15 70.6 5.2 -8 0 11 385.0 7.2 -8 2 20 199.7 4.2 -9 30 1 31.9 7.6 -9 33 16 21.8 9.1 -8 0 12 61.4 15.5 -8 2 21 323.7 5.5 -9 30 2 188.1 4.1 -9 33 17 96.0 8.9 -8 0 13 479.0 9.2 -8 2 22 220.2 3.6 WO 99/10379 PCT/GB98/02542 -75 -8 2 23 101.4 5.8 -8 4 31 224.7 5.5 -8 7 7 215.4 3.4 -8 9 15 152.3 3.6 -8 2 24 301.7 4.7 -8 4 32 224.2 4.3 -8 7 8 413.1 5.0 -8 9 16 154.9 3.4 -8 2 25 192.7 3.6 -8 5 1 536.6 10.3 -8 7 9 135.2 2.8 -8 9 17 187.7 3.6 -8 2 26 26.6 10.8 -8 5 2 101.8 2.5 -8 7 10 469.4 5.7 -8 9 18 305.5 4.6 -8 2 27 18.5 8.7 -8 5 3 799.5 11.0 -8 7 11 796.8 11.3 -8 9 19 71.3 5.9 -8 2 28 157.5 5.0 -8 5 4 187.8 3.0 -8 7 12 168.7 3.7 -8 9 20 137.5 3.4 -8 2 29 72.8 6.9 -8 5 5 278.2 3.7 -8 7 13 251.9 4.8 -8 9 21 78.5 4.4 -8 2 30 207.3 4.6 -8 5 6 428.0 5.7 -8 7 14 282.4 4.3 -8 9 22 215.7 3.7 -8 2 31 132.8 6.6 -8 5 7 576.4 6.5 -8 7 15 195.1 3.7 -8 9 23 131.7 3.4 -8 2 32 81.8 7.8 -8 5 8 226.3 3.6 -8 7 16 162.8 3.7 -8 9 24 178.6 3.6 -8 3 1 252.3 5.2 -8 5 9 246.8 3.6 -8 7 17 377.8 5.2 -8 9 25 81.0 5.1 -8 3 2 348.7 5.1 -8 5 10 476.3 7.2 -8 7 18 128.1 3.9 -8 9 26 190.3 3.6 -8 3 3 570.9 7.2 -8 5 11 263.4 3.9 -8 7 19 286.0 4.5 -8 9 27 232.2 14.0 -8 3 4 206.9 3.2 -8 5 12 103.0 4.7 -8 7 20 257.6 4.1 -8 9 28 288.4 4.7 -8 3 5 84.1 3.3 -8 5 13 449.0 6.8 -8 7 21 143.6 3.5 -8 9 29 105.1 6.1 -8 3 6 400.9 8.5 -8 5 14 639.5 9.8 -8 7 22 164.8 3.4 -8 9 30 104.9 6.6 -8 3 7 170.0 3.0 -8 5 15 386.8 6.2 -8 7 23 117.7 4.0 -8 9 31 95.1 7.8 -8 3 8 563.1 8.6 -8 5 16 480.0 7.1 -8 7 24 186.2 3.5 -8 10 1 468.1 7.4 -8 3 9 235.1 3.5 -8 5 17 239.3 4.0 -8 7 25 195.3 3.9 -8 10 2 729.3 11.5 -8 3 10 385.8 5.2 -8 5 18 270.3 5.2 -8 7 26 149.8 4.1 -8 10 3 357.3 5.1 -8 3 11 596.9 7.8 -8 5 19 211.9 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6 29 285.8 4.7 -8 9 5 165.0 3.1 -8 11 15 240.1 4.0 -8 4 22 381.0 4.8 -8 6 30 35.0 12.5 -8 9 6 284.2 3.8 -8 11 16 181.6 3.4 -8 4 23 39.4 10.4 -8 6 31 298.9 4.8 -8 9 7 412.1 5.1 -8 11 17 147.3 3.4 -8 4 24 417.8 6.1 -8 6 32 104.9 6.1 -8 9 8 494.6 7.2 -8 11 18 104.4 6.8 -8 4 25 201.7 3.8 -8 7 1 356.5 5.3 -8 9 9 679.2 10.1 -8 11 19 181.7 3.4 -8 4 26 96.2 6.4 -8 7 2 424.5 5.4 -8 9 10 466.2 6.5 -8 11 20 365.4 5.6 -8 4 27 76.5 6.1 -8 7 3 775.0 10.1 -8 9 11 171.3 3.3 -8 11 21 112.3 4.1 -8 4 28 107.9 6.8 -8 7 4 165.9 2.8 -8 9 12 518.1 8.0 -8 11 22 365.9 5.7 -8 4 29 126.8 4.6 -8 7 5 212.9 3.4 -8 9 13 270.3 4.2 -8 11 23 54.5 8.2 -8 4 30 113.7 6.0 -8 7 6 376.4 5.2 -8 9 14 411.0 6.4 -8 11 24 107.1 3.8 WO 99/10379 PCT/GB98/02542 -76 -8 11 25 162.1 3.4 -8 14 5 129.6 3.5 -8 16 18 112.9 3.2 -8 19 3 229.6 3.9 -8 11 26 259.6 5.1 -8 14 6 384.8 5.2 -8 16 19 331.3 4.6 -8 19 4 259.3 3.6 -8 11 27 199.8 4.4 -8 14 7 255.3 4.9 -8 16 20 300.0 4.2 -8 19 5 100.2 3.4 -8 11 28 118.3 5.7 -8 14 8 138.9 7.9 -8 16 21 310.2 4.2 -8 19 6 150.7 2.9 -8 11 29 217.3 4.8 -8 14 9 147.2 2.9 -8 16 22 143.0 3.5 -8 19 7 499.5 7.5 -8 11 30 125.5 5.3 -8 14 10 452.9 7.5 -8 16 23 148.8 3.6 -8 19 8 462.5 5.6 -8 11 31 134.4 5.2 -8 14 11 267.5 4.4 -8 16 24 131.3 3.8 -8 19 9 370.2 5.1 -8 12 1 402.7 6.6 -8 14 12 368.6 5.7 -8 16 25 51.5 10.7 -8 19 10 260.8 3.9 -8 12 2 922.2 17.4 -8 14 13 114.7 3.7 -8 16 26 178.8 4.0 -8 19 11 54.8 4.9 -8 12 3 189.1 2.9 -8 14 14 406.6 6.3 -8 16 27 140.7 4.1 -8 19 12 302.3 4.8 -8 12 4 389.9 5.3 -8 14 15 375.6 5.5 -8 16 28 96.0 5.5 -8 19 13 362.5 4.9 -8 12 5 371.8 5.0 -8 14 16 294.2 4.4 -8 16 29 156.7 4.5 -8 19 14 412.2 5.6 -8 12 6 308.5 4.3 -8 14 17 273.4 4.1 -8 16 30 117.4 6.0 -8 19 15 179.6 3.0 -8 12 7 274.8 4.4 -8 14 18 274.7 4.4 -8 17 1 198.8 3.8 -8 19 16 270.1 4.2 -8 12 8 20.7 8.6 -8 14 19 275.4 4.4 -8 17 2 305.1 5.3 -8 19 17 446.8 6.2 -8 12 9 325.9 5.0 -8 14 20 189.3 3.5 -8 17 3 233.8 4.3 -8 19 18 134.5 3.2 -8 12 10 527.5 7.7 -8 14 21 123.9 4.0 -8 17 4 227.2 3.6 -8 19 19 306.5 4.6 -8 12 11 273.4 3.8 -8 14 22 232.4 3.5 -8 17 5 113.2 3.3 -8 19 20 156.8 3.3 -8 12 12 369.3 6.1 -8 14 23 77.9 4.4 -8 17 6 527.3 6.6 -8 19 21 261.4 3.7 -8 12 13 91.5 5.2 -8 14 24 243.9 3.9 -8 17 7 409.8 5.7 -8 19 22 58.1 6.3 -8 12 14 194.9 3.4 -8 14 25 179.5 4.4 -8 17 8 185.7 3.3 -8 19 23 324.2 6.8 -8 12 15 415.5 5.3 -8 14 26 193.9 3.9 -8 17 9 430.6 6.2 -8 19 24 127.5 4.2 -8 12 16 377.5 5.3 -8 14 27 87.6 5.4 -8 17 10 404.6 5.9 -8 19 25 51.3 7.9 -8 12 17 209.8 3.4 -8 14 28 150.0 4.6 -8 17 11 161.0 3.2 -8 19 26 87.6 5.1 -8 12 18 332.2 4.7 -8 14 29 44.3 14.4 -8 17 12 170.5 3.1 -8 19 27 186.6 4.3 -8 12 19 198.1 3.8 -8 14 30 97.8 6.7 -8 17 13 431.8 6.5 -8 19 28 206.7 4.0 -8 12 20 281.9 4.5 -8 15 1 272.3 4.0 -8 17 14 348.8 4.9 -8 20 1 197.8 3.4 -8 12 21 154.9 3.4 -8 15 2 104.7 3.8 -8 17 15 184.7 3.1 -8 20 2 153.0 4.3 -8 12 22 87.2 4.0 -8 15 3 715.6 9.8 -8 17 16 239.3 4.5 -8 20 3 220.0 3.9 -8 12 23 285.9 4.2 -8 15 4 384.4 6.0 -8 17 17 38.3 7.8 -8 20 4 202.1 3.0 -8 12 24 185.3 3.6 -8 15 5 239.8 4.2 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8.7 -8 13 7 324.5 5.4 -8 15 19 156.1 3.1 -8 18 3 177.3 3.0 -8 20 19 96.3 3.7 -8 13 8 568.2 7.5 -8 15 20 172.7 3.2 -8 18 4 259.4 4.0 -8 20 20 112.0 3.4 -8 13 9 205.5 7.2 -8 15 21 70.7 5.3 -8 18 5 514.4 7.8 -8 20 21 267.9 4.3 -8 13 10 327.1 4.2 -8 15 22 279.7 4.4 -8 18 6 348.6 5.3 -8 20 22 55.0 7.6 -8 13 11 514.5 7.7 -8 15 23 26.3 11.9 -8 18 7 201.3 3.1 -8 20 23 38.8 11.6 -8 13 12 326.2 4.5 -8 15 24 290.5 4.3 -8 18 8 277.2 4.4 -8 20 24 89.7 4.2 -8 13 13 295.4 4.8 -8 15 25 163.9 7.5 -8 18 9 176.9 3.4 -8 20 25 202.7 3.9 -8 13 14 382.3 5.3 -8 15 26 78.1 5.6 -8 18 10 417.4 6.5 -8 20 26 85.8 6.9 -8 13 15 293.4 4.5 -8 15 27 93.5 6.7 -8 18 11 318.2 5.2 -8 20 27 98.7 5.2 -8 13 16 332.7 5.5 -8 15 28 202.0 4.2 -8 18 12 281.2 3.8 -8 20 28 24.4 11.2 -8 13 17 256.7 4.1 -8 15 29 80.3 7.0 -8 18 13 167.3 2.9 -8 21 1 224.5 4.5 -8 13 18 170.7 3.9 -8 15 30 60.6 9.3 -8 18 14 176.9 3.1 -8 21 2 234.7 4.0 -8 13 19 217.1 3.5 -8 16 1 164.7 5.2 -8 18 15 251.1 3.6 -8 21 3 241.5 3.8 -8 13 20 214.1 3.6 -8 16 3 487.3 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9.1 -8 14 4 359.7 4.8 -8 16 17 318.1 5.4 -8 19 2 104.1 3.7 -8 21 18 208.9 3.1 WO 99/10379 PCT/GB98/02542 -77 -8 21 19 37.9 8.8 -8 24 11 225.5 3.2 -8 27 7 48.2 5.6 -8 30 10 141.2 2.7 -8 21 20 141.8 3.7 -8 24 12 100.5 3.0 -8 27 8 139.9 2.5 -8 30 11 81.1 4.1 -8 21 21 28.1 11.4 -8 24 13 144.0 2.8 -8 27 9 182.2 2.7 -8 30 12 82.7 4.1 -8 21 22 224.1 7.8 -8 24 14 61.6 5.5 -8 27 10 137.7 2.6 -8 30 13 226.7 7.9 -8 21 23 20.0 9.0 -8 24 15 232.9 3.4 -8 27 11 209.1 3.0 -8 30 14 95.0 4.0 -8 21 24 93.8 6.6 -8 24 16 162.2 2.9 -8 27 12 110.6 3.0 -8 30 15 108.6 2.9 -8 21 25 54.0 10.7 -8 24 17 212.8 3.4 -8 27 13 128.6 3.0 -8 30 16 115.0 3.4 -8 21 26 131.4 4.9 -8 24 18 38.6 8.5 -8 27 14 64.4 4.3 -8 30 17 206.5 3.6 -8 21 27 66.0 8.4 -8 24 19 227.0 3.6 -8 27 15 235.6 3.8 -8 30 18 129.9 3.7 -8 22 1 275.5 7.6 -8 24 20 73.2 9.9 -8 27 16 160.9 3.3 -8 30 19 41.3 8.6 -8 22 2 276.7 4.7 -8 24 21 218.9 4.2 -8 27 17 370.4 9.8 -8 30 20 205.8 3.6 -8 22 3 184.2 3.6 -8 24 22 117.9 3.9 -8 27 18 207.8 3.5 -8 30 21 183.4 3.4 -8 22 4 205.2 3.5 -8 24 23 92.8 5.1 -8 27 19 18.5 8.4 -8 31 1 290.7 5.7 -8 22 5 263.9 3.5 -8 24 24 228.7 4.0 -8 27 20 78.0 5.6 -8 31 2 254.3 5.2 -8 22 6 545.5 6.7 -8 24 25 161.0 3.7 -8 27 21 51.0 6.9 -8 31 3 205.5 4.2 -8 22 7 386.6 5.6 -8 24 26 125.5 4.4 -8 27 22 124.4 3.8 -8 31 4 300.0 6.9 -8 22 8 210.0 3.3 -8 25 1 133.0 4.0 -8 27 23 127.6 4.8 -8 31 5 284.4 9.1 -8 22 9 74.6 3.9 -8 25 2 252.1 5.1 -8 27 24 33.7 12.7 -8 31 6 135.6 2.9 -8 22 10 101.3 3.3 -8 25 3 210.3 4.6 -8 28 1 82.3 5.0 -8 31 7 140.5 3.0 -8 22 11 202.5 4.5 -8 25 4 193.2 3.4 -8 28 2 236.0 4.6 -8 31 8 136.9 2.5 -8 22 12 50.5 4.8 -8 25 5 201.2 2.9 -8 28 3 269.4 5.2 -8 31 9 171.7 2.8 -8 22 13 96.4 3.4 -8 25 6 136.8 2.8 -8 28 4 91.0 3.4 -8 31 10 137.9 2.9 -8 22 14 23.5 10.3 -8 25 7 209.4 3.0 -8 28 5 66.0 4.6 -8 31 11 158.8 8.5 -8 22 15 66.9 4.4 -8 25 8 56.0 4.9 -8 28 6 117.5 2.5 -8 31 12 50.9 10.8 -8 22 16 65.4 4.7 -8 25 9 362.8 5.0 -8 28 7 132.3 2.6 -8 31 13 222.0 3.3 -8 22 17 196.5 3.6 -8 25 10 173.1 2.8 -8 28 8 141.0 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7.2 -8 23 18 62.8 4.8 -8 26 13 81.4 4.5 -8 29 13 48.4 6.8 -8 33 3 13.4 6.8 -8 23 19 127.5 3.2 -8 26 14 25.3 8.8 -8 29 14 32.5 12.7 -8 33 4 46.0 10.3 -8 23 20 142.5 4.0 -8 26 15 355.2 5.0 -8 29 15 100.3 7.3 -8 33 5 151.3 4.7 -8 23 21 16.9 8.2 -8 26 16 68.1 5.3 -8 29 16 182.7 3.1 -8 33 6 221.2 10.8 -8 23 22 55.9 8.1 -8 26 17 98.9 3.8 -8 29 17 187.1 3.3 -8 33 7 126.3 6.9 -8 23 23 115.4 3.7 -8 26 18 193.5 7.8 -8 29 18 237.4 4.5 -8 33 8 161.9 3.0 -8 23 24 135.2 4.0 -8 26 19 224.0 3.7 -8 29 19 86.0 4.9 -8 33 9 140.6 3.2 -8 23 25 82.5 6.4 -8 26 20 184.4 3.4 -8 29 20 20.3 9.0 -8 33 10 139.6 3.3 -8 23 26 68.8 7.4 -8 26 21 246.7 4.3 -8 29 21 22.7 9.4 -8 33 11 61.2 4.0 -8 24 1 160.0 3.0 -8 26 22 42.6 10.2 -8 29 22 36.0 11.1 -8 33 12 75.8 3.7 -8 24 2 511.2 8.3 -8 26 23 142.6 3.8 -8 30 1 163.3 4.0 -8 33 13 81.1 3.9 -8 24 3 209.3 4.6 -8 26 24 239.8 4.3 -8 30 2 159.2 3.7 -8 33 14 163.4 3.2 -8 24 4 176.2 4.2 -8 26 25 84.6 5.5 -8 30 3 96.7 2.9 -8 33 15 90.6 3.6 -8 24 5 141.0 2.5 -8 27 1 118.7 4.0 -8 30 4 19.6 7.9 -8 33 16 213.7 3.1 -8 24 6 142.6 2.5 -8 27 2 94.2 4.1 -8 30 5 225.1 3.6 -8 33 17 63.8 7.1 -8 24 7 125.6 2.5 -8 27 3 49.4 4.8 -8 30 6 163.9 3.2 -8 33 18 109.6 4.5 -8 24 8 193.2 2.9 -8 27 4 432.4 7.5 -8 30 7 199.4 3.8 -8 34 1 79.6 7.2 -8 24 9 61.8 3.3 -8 27 5 94.4 2.5 -8 30 8 119.8 2.7 -8 34 2 71.2 8.0 -8 24 10 320.0 5.1 -8 27 6 113.0 2.8 -8 30 9 112.3 3.2 -8 34 3 86.2 8.4 WO 99/10379 PCT/GB98/02542 -78 -8 34 4 79.4 5.6 -8 39 7 172.7 9.0 -7 2 6 321.3 5.1 -7 4 13 370.1 5.2 -8 34 5 96.6 5.4 -7 0 1 15.3 9.8 -7 2 7 226.7 3.7 -7 4 14 424.6 5.8 -8 34 6 149.8 3.1 -7 0 2 429.2 8.1 -7 2 8 242.3 3.3 -7 4 15 355.9 5.9 -8 34 7 194.9 3.2 -7 0 3 191.8 3.9 -7 2 9 219.6 3.2 -7 4 16 614.3 9.7 -8 34 8 63.2 4.1 -7 0 4 292.8 4.9 -7 2 10 740.6 9.8 -7 4 17 423.3 7.1 -8 34 9 130.9 2.7 -7 0 5 203.7 4.3 -7 2 11 436.5 6.4 -7 4 18 231.0 3.9 -8 34 10 243.1 5.0 -7 0 6 667.4 14.2 -7 2 12 658.4 8.9 -7 4 19 257.4 3.9 -8 34 11 90.4 3.8 -7 0 7 277.9 6.0 -7 2 13 342.8 5.4 -7 4 20 127.3 3.9 -8 34 12 273.5 4.6 -7 0 8 327.4 6.1 -7 2 14 498.2 6.9 -7 4 21 118.4 3.9 -8 34 13 176.4 3.5 -7 0 9 302.9 5.6 -7 2 15 442.2 6.4 -7 4 22 179.7 3.6 -8 34 14 173.7 3.2 -7 0 10 77.8 5.8 -7 2 16 254.4 4.3 -7 4 23 177.0 3.4 -8 34 15 92.4 3.7 -7 0 11 383.3 7.8 -7 2 17 356.0 5.7 -7 4 24 171.4 3.4 -8 34 16 109.8 3.5 -7 0 12 12.8 9.0 -7 2 18 323.0 5.0 -7 4 25 248.5 4.1 -8 34 17 98.3 4.0 -7 0 13 93.7 5.8 -7 2 19 146.4 4.4 -7 4 26 218.3 3.7 -8 35 1 134.3 4.1 -7 0 14 269.7 5.9 -7 2 20 254.6 4.4 -7 4 27 231.4 3.9 -8 35 2 119.6 3.7 -7 0 15 195.7 10.1 -7 2 21 140.6 4.9 -7 4 28 114.0 12.6 -8 35 3 65.3 6.6 -7 0 16 90.0 5.3 -7 2 22 190.0 3.7 -7 4 29 196.1 4.1 -8 35 4 261.8 5.5 -7 0 17 357.8 7.8 -7 2 23 50.1 8.0 -7 4 30 83.5 6.0 -8 35 5 82.9 5.4 -7 0 18 155.4 4.8 -7 2 24 210.0 3.7 -7 4 31 142.8 5.1 -8 35 6 84.5 6.4 -7 0 19 98.6 6.5 -7 2 25 16.3 7.9 -7 4 32 105.0 6.1 -8 35 7 177.7 3.2 -7 0 20 104.7 5.1 -7 2 26 186.5 3.5 -7 4 33 43.0 13.1 -8 35 8 157.0 3.4 -7 0 21 257.9 5.9 -7 2 27 107.3 5.0 -7 5 1 136.5 3.6 -8 35 9 171.3 2.8 -7 0 22 356.8 7.2 -7 2 28 164.8 6.6 -7 5 2 287.9 4.0 -8 35 10 203.7 3.7 -7 0 23 204.0 4.9 -7 2 29 139.9 4.1 -7 5 3 270.3 3.7 -8 35 11 119.9 3.2 -7 0 24 339.7 7.4 -7 2 30 117.6 5.8 -7 5 4 518.9 7.7 -8 35 12 161.9 3.4 -7 0 25 219.7 5.5 -7 2 31 222.4 4.9 -7 5 5 498.1 6.9 -8 35 13 129.0 3.1 -7 0 26 120.0 5.5 -7 2 32 72.9 8.9 -7 5 6 668.1 8.8 -8 35 14 74.4 4.4 -7 0 27 303.6 7.3 -7 2 33 38.6 13.0 -7 5 7 267.0 3.3 -8 35 15 172.9 3.0 -7 0 28 14.6 10.8 -7 3 1 521.3 9.9 -7 5 8 679.4 9.2 -8 35 16 106.3 4.7 -7 0 29 13.7 10.2 -7 3 2 304.5 4.2 -7 5 9 375.1 5.5 -8 36 1 62.0 5.6 -7 0 30 60.9 15.7 -7 3 3 217.4 4.0 -7 5 10 985.9 13.7 -8 36 2 58.1 6.9 -7 0 31 229.6 6.6 -7 3 4 387.3 6.5 -7 5 11 236.5 3.7 -8 36 3 154.1 4.2 -7 0 32 15.4 11.0 -7 3 5 112.0 2.5 -7 5 12 270.6 5.6 -8 36 4 93.2 4.8 -7 0 33 128.0 7.5 -7 3 6 340.8 5.0 -7 5 13 255.6 4.1 -8 36 5 116.7 4.4 -7 1 1 348.5 4.1 -7 3 7 529.9 8.0 -7 5 14 276.6 4.1 -8 36 6 120.5 5.7 -7 1 2 90.7 2.5 -7 3 8 300.8 4.2 -7 5 15 197.5 3.8 -8 36 7 65.7 5.1 -7 1 3 190.5 2.6 -7 3 9 688.7 8.9 -7 5 16 216.1 3.8 -8 36 8 42.6 5.6 -7 1 4 251.5 3.1 -7 3 10 390.0 5.1 -7 5 17 255.9 4.5 -8 36 9 230.7 3.5 -7 1 5 254.8 4.0 -7 3 11 150.0 2.8 -7 5 18 278.8 4.4 -8 36 10 95.9 3.5 -7 1 6 228.8 3.5 -7 3 12 231.1 3.3 -7 5 19 164.9 3.5 -8 36 11 296.5 5.1 -7 1 7 513.8 8.0 -7 3 13 23.9 9.6 -7 5 20 207.4 3.9 -8 36 12 124.6 3.4 -7 1 8 536.4 6.9 -7 3 14 58.5 9.2 -7 5 21 304.4 4.8 -8 36 13 82.5 3.6 -7 1 9 438.6 6.8 -7 3 15 298.4 5.8 -7 5 22 201.8 3.6 -8 36 14 19.5 9.1 -7 1 10 187.7 3.1 -7 3 16 365.8 5.7 -7 5 23 263.1 4.2 -8 37 1 102.9 4.0 -7 1 11 140.1 2.8 -7 3 17 330.5 5.5 -7 5 24 143.7 4.0 -8 37 2 221.4 4.3 -7 1 12 162.3 2.9 -7 3 18 333.7 5.1 -7 5 25 40.3 9.3 -8 37 3 309.8 24.9 -7 1 13 396.6 6.2 -7 3 19 419.0 5.8 -7 5 26 194.5 3.7 -8 37 4 299.5 6.3 -7 1 14 542.9 7.6 -7 3 20 163.7 3.8 -7 5 27 142.0 3.6 -8 37 5 142.8 3.9 -7 1 15 495.1 7.7 -7 3 21 140.6 4.2 -7 5 28 256.9 8.3 -8 37 6 100.6 4.7 -7 1 16 423.6 7.0 -7 3 22 235.7 3.7 -7 5 29 141.2 5.2 -8 37 7 94.3 3.6 -7 1 17 584.7 9.1 -7 3 23 299.7 4.4 -7 5 30 128.8 4.8 -8 37 8 212.8 4.0 -7 1 18 308.3 4.8 -7 3 24 152.9 3.3 -7 5 31 182.4 4.9 -8 37 9 81.9 4.0 -7 1 19 18.5 9.1 -7 3 25 108.0 3.9 -7 5 32 44.5 13.3 -8 37 10 68.4 4.2 -7 1 20 36.9 10.0 -7 3 26 78.3 6.8 -7 6 1 226.7 3.7 -8 37 11 136.1 2.9 -7 1 21 167.2 3.4 -7 3 27 97.4 5.3 -7 6 2 235.7 3.3 -8 37 12 14.4 7.2 -7 1 22 381.0 5.3 -7 3 29 247.5 4.7 -7 6 3 132.1 2.4 -8 38 1 50.2 7.8 -7 1 23 172.9 3.3 -7 3 30 88.3 6.2 -7 6 4 451.4 5.7 -8 38 2 114.0 4.3 -7 1 24 39.0 8.8 -7 3 31 203.8 4.5 -7 6 5 384.9 5.5 -8 38 3 60.1 6.0 -7 1 25 138.6 3.8 -7 3 32 145.9 4.6 -7 6 6 113.2 2.7 -8 38 4 141.2 4.2 -7 1 26 38.3 12.1 -7 3 33 24.6 11.1 -7 6 7 270.4 3.8 -8 38 5 57.4 7.1 -7 1 27 112.2 4.3 -7 4 1 77.7 3.4 -7 6 8 181.1 2.8 -8 38 6 87.7 5.5 -7 1 28 242.5 6.2 -7 4 2 334.6 6.0 -7 6 9 456.5 6.3 -8 38 7 87.8 7.8 -7 1 29 155.7 3.8 -7 4 3 275.4 4.0 -7 6 10 398.4 5.6 -8 38 8 102.5 3.4 -7 1 30 52.4 10.9 -7 4 4 470.4 8.5 -7 6 11 110.3 3.0 -8 38 9 84.3 3.2 -7 1 31 198.4 4.8 -7 4 5 626.0 8.1 -7 6 12 378.7 5.6 -8 38 10 212.5 3.9 -7 1 32 27.0 11.4 -7 4 6 340.2 5.1 -7 6 13 326.4 4.6 -8 39 1 155.3 4.2 -7 1 33 66.0 9.3 -7 4 7 101.1 3.7 -7 6 14 362.4 5.3 -8 39 2 198.9 4.6 -7 2 1 196.8 2.9 -7 4 8 417.1 7.0 -7 6 15 219.7 3.7 -8 39 3 84.9 5.3 -7 2 2 295.5 3.9 -7 4 9 663.9 8.7 -7 6 16 657.6 9.9 -8 39 4 74.4 5.0 -7 2 3 112.3 2.4 -7 4 10 408.8 5.2 -7 6 17 157.6 3.4 -8 39 5 133.1 3.8 -7 2 4 221.6 3.0 -7 4 11 338.4 5.4 -7 6 18 331.2 4.8 -8 39 6 97.2 4.7 -7 2 5 193.2 2.8 -7 4 12 298.9 4.0 -7 6 19 209.3 3.7 WO 99/10379 PCT/GB98/02542 -79 -7 6 20 227.8 4.3 -7 8 28 142.9 5.2 -7 11 5 290.8 4.5 -7 13 15 141.7 3.9 -7 6 21 211.3 3.7 -7 8 29 70.3 7.0 -7 11 6 528.5 7.0 -7 13 16 219.9 3.8 -7 6 22 190.4 3.6 -7 8 30 196.3 4.3 -7 11 7 453.9 5.8 -7 13 17 265.0 4.3 -7 6 23 85.8 7.5 -7 8 31 166.4 5.2 -7 11 8 319.6 4.7 -7 13 18 217.7 3.7 -7 6 24 299.5 4.3 -7 8 32 107.1 6.3 -7 11 9 227.9 3.2 -7 13 19 145.6 3.4 -7 6 25 130.6 3.5 -7 9 1 184.7 5.8 -7 11 10 362.5 4.5 -7 13 20 204.1 3.6 -7 6 26 132.7 4.8 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8 264.2 3.6 -7 9 17 203.1 3.8 -7 11 25 168.2 4.1 -7 14 4 173.0 2.7 -7 7 9 222.0 3.4 -7 9 18 97.0 6.6 -7 11 26 109.1 4.5 -7 14 5 763.9 9.6 -7 7 10 143.4 2.9 -7 9 19 55.7 6.4 -7 11 27 307.4 8.0 -7 14 6 571.0 7.2 -7 7 11 350.3 4.7 -7 9 20 252.4 3.8 -7 11 28 223.3 4.4 -7 14 7 472.4 6.4 -7 7 12 411.7 6.1 -7 9 21 258.3 4.1 -7 11 29 271.1 4.5 -7 14 8 633.0 9.2 -7 7 13 586.5 8.8 -7 9 22 323.1 5.6 -7 11 30 40.8 15.5 -7 14 9 413.2 6.5 -7 7 14 518.9 7.4 -7 9 23 98.5 4.4 -7 11 31 122.8 7.2 -7 14 10 267.7 4.8 -7 7 15 279.4 4.2 -7 9 24 96.1 4.2 -7 11 32 155.8 6.9 -7 14 11 454.7 7.0 -7 7 16 324.8 5.3 -7 9 25 122.0 4.0 -7 12 1 637.9 9.9 -7 14 12 787.5 11.8 -7 7 17 171.6 3.6 -7 9 26 89.0 4.8 -7 12 2 623.6 9.0 -7 14 13 311.8 4.6 -7 7 18 226.5 3.9 -7 9 27 92.2 6.2 -7 12 3 376.2 5.1 -7 14 14 219.6 3.7 -7 7 19 24.8 10.3 -7 9 28 15.9 7.9 -7 12 4 322.7 5.4 -7 14 15 83.3 4.3 -7 7 20 214.6 3.7 -7 9 29 333.1 5.2 -7 12 5 583.3 7.4 -7 14 16 128.2 3.8 -7 7 21 187.4 3.9 -7 9 30 191.3 4.5 -7 12 6 209.6 2.8 -7 14 17 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266.1 4.6 -7 18 9 235.6 4.0 -7 20 23 26.2 12.5 -7 23 11 253.4 3.4 -7 15 28 178.9 4.8 -7 18 10 140.4 2.9 -7 20 24 189.9 3.7 -7 23 12 228.2 3.4 -7 15 29 108.9 5.9 -7 18 11 135.1 3.0 -7 20 25 45.3 8.4 -7 23 13 56.9 4.6 -7 15 30 201.7 4.3 -7 18 12 404.8 6.7 -7 20 26 141.4 6.1 -7 23 14 215.2 3.3 -7 16 1 266.4 6.4 -7 18 13 174.6 3.0 -7 20 27 88.5 5.6 -7 23 15 70.8 5.1 -7 16 2 536.7 8.0 -7 18 14 190.6 3.4 -7 20 28 140.1 5.3 -7 23 16 65.0 4.9 -7 16 3 498.9 6.8 -7 18 15 278.0 4.3 -7 21 1 535.8 10.1 -7 23 17 279.8 4.5 -7 16 4 645.6 9.4 -7 18 16 143.6 3.0 -7 21 2 28.8 11.1 -7 23 18 256.4 3.7 -7 16 5 275.5 4.5 -7 18 17 345.4 5.3 -7 21 3 251.7 4.5 -7 23 20 107.3 3.4 -7 16 6 367.5 4.6 -7 18 18 169.3 3.8 -7 21 4 275.2 4.0 -7 23 21 51.0 11.7 -7 16 7 159.6 5.1 -7 18 19 184.9 3.6 -7 21 5 296.8 4.2 -7 23 22 133.2 4.5 -7 16 8 339.7 5.0 -7 18 20 111.8 3.6 -7 21 6 252.4 3.9 -7 23 23 71.6 5.6 -7 16 9 405.4 6.0 -7 18 21 82.1 5.1 -7 21 7 165.9 2.8 -7 23 24 16.1.6 3.6 -7 16 10 290.5 5.1 -7 18 22 50.4 10.2 -7 21 8 82.6 3.4 -7 23 25 75.7 6.0 -7 16 11 200.4 3.6 -7 18 23 280.0 4.5 -7 21 9 166.2 2.9 -7 23 26 80.6 8.5 -7 16 12 74.6 4.0 -7 18 24 19.2 9.5 -7 21 10 346.8 5.2 -7 23 27 70.2 8.1 -7 16 13 406.8 5.6 -7 18 25 101.6 5.3 -7 21 11 708.5 9.9 -7 24 1 238.9 5.2 -7 16 14 256.8 4.0 -7 18 26 246.1 4.5 -7 21 12 303.8 4.4 -7 24 2 225.7 4.7 -7 16 15 169.1 3.0 -7 18 27 141.3 4.8 -7 21 13 113.8 3.4 -7 24 4 238.3 3.1 -7 16 16 292.8 4.7 -7 18 28 180.2 4.3 -7 21 14 61.1 4.9 -7 24 5 47.3 3.7 -7 16 17 226.2 3.8 -7 18 29 216.5 5.1 -7 21 15 128.0 3.0 -7 24 6 62.9 3.9 -7 16 18 443.9 6.8 -7 19 1 306.2 5.3 -7 21 16 73.2 4.0 -7 24 7 113.5 2.5 -7 16 19 323.8 4.8 -7 19 2 406.1 7.3 -7 21 17 118.7 3.3 -7 24 8 200.5 3.2 -7 16 20 178.4 3.8 -7 19 3 169.7 2.8 -7 21 18 197.1 3.4 -7 24 9 251.3 3.5 -7 16 21 141.9 3.6 -7 19 4 201.5 2.9 -7 21 19 88.3 3.4 -7 24 10 57.2 4.5 -7 16 22 70.2 4.7 -7 19 5 147.9 3.3 -7 21 20 97.9 3.9 -7 24 11 270.5 3.5 -7 16 23 181.5 3.6 -7 19 6 237.2 3.5 -7 21 21 25.4 10.2 -7 24 12 226.2 3.4 -7 16 24 228.1 3.9 -7 19 7 93.8 3.3 -7 21 22 79.4 4.9 -7 24 13 77.3 3.6 -7 16 25 29.7 14.2 -7 19 8 287.6 4.1 -7 21 23 16.4 8.3 -7 24 14 146.8 2.8 -7 16 26 380.6 6.1 -7 19 9 327.5 4.9 -7 21 24 107.2 4.4 -7 24 15 129.9 3.6 -7 16 27 235.6 4.2 -7 19 10 696.8 9.2 -7 21 25 124.8 5.6 -7 24 16 177.3 3.4 -7 16 28 123.1 4.8 -7 19 11 376.6 6.5 -7 21 26 39.4 12.5 -7 24 17 326.0 4.6 -7 16 29 116.3 5.8 -7 19 12 183.9 3.3 -7 21 27 107.6 5.7 -7 24 18 146.4 3.1 -7 16 30 29.8 12.3 -7 19 13 355.5 5.0 -7 21 28 124.6 6.6 -7 24 19 83.2 4.2 -7 17 1 278.5 6.7 -7 19 14 61.8 5.1 -7 22 1 45.0 5.7 -7 24 20 85.6 4.6 -7 17 2 878.5 12.7 -7 19 15 344.8 5.5 -7 22 2 564.8 9.9 -7 24 21 63.5 7.2 -7 17 3 410.1 5.5 -7 19 16 201.6 3.3 -7 22 3 224.4 3.4 -7 24 22 210.0 3.7 -7 17 4 479.8 7.0 -7 19 17 303.8 4.2 -7 22 4 611.9 8.2 -7 24 23 123.8 3.8 -7 17 5 353.0 5.2 -7 19 18 78.8 4.4 -7 22 5 148.9 2.7 -7 24 24 125.5 5.2 -7 17 6 601.7 8.3 -7 19 19 386.3 6.2 -7 22 6 151.2 2.6 -7 24 25 158.7 5.3 -7 17 7 238.7 3.6 -7 19 20 347.6 5.1 -7 22 7 431.3 6.0 -7 24 26 31.8 11.3 -7 17 8 284.7 4.4 -7 19 21 157.6 3.5 -7 22 8 348.1 6.0 -7 25 1 90.2 4.4 -7 17 9 135.9 3.7 -7 19 22 118.1 3.4 -7 22 9 226.3 3.4 -7 25 2 301.3 6.8 -7 17 10 339.6 4.9 -7 19 23 106.4 4.1 -7 22 10 92.0 3.2 -7 25 3 158.7 3.8 -7 17 11 92.5 4.1 -7 19 24 185.7 9.6 -7 22 11 61.3 4.2 -7 25 4 215.4 4.1 -7 17 12 359.1 5.2 -7 19 25 93.4 5.9 -7 22 12 218.7 3.3 -7 25 5 48.4 3.9 -7 17 13 303.6 4.6 -7 19 26 79.9 5.6 -7 22 13 309.8 4.4 -7 25 6 151.6 2.6 -7 17 14 274.1 4.1 -7 19 27 83.2 6.5 -7 22 14 304.8 4.4 -7 25 7 66.5 3.5 -7 17 15 233.6 4.1 -7 19 28 62.6 7.7 -7 22 15 46.7 5.3 -7 25 8 276.3 4.3 -7 17 16 254.0 4.3 -7 19 29 225.0 5.0 -7 22 16 225.9 3.5 -7 25 9 226.2 3.2 -7 17 17 259.8 3.9 -7 20 1 639.5 12.6 -7 22 17 34.5 8.4 -7 25 10 70.0 3.3 -7 17 18 272.6 3.8 -7 20 2 513.8 9.4 -7 22 18 159.7 3.0 -7 25 11 323.4 4.7 -7 17 19 160.3 3.9 -7 20 3 374.4 5.9 -7 22 19 151.4 3.3 -7 25 12 120.4 2.7 -7 17 20 91.2 4.6 -7 20 4 291.0 4.7 -7 22 20 105.5 3.8 -7 25 13 63.4 3.3 -7 17 21 170.0 3.1 -7 20 5 184.7 2.9 -7 22 21 170.4 3.6 -7 25 14 408.6 6.1 -7 17 22 169.9 3.4 -7 20 6 286.8 3.7 -7 22 22 303.6 6.2 -7 25 15 59.7 5.2 -7 17 23 334.8 4.8 -7 20 7 242.1 3.3 -7 22 23 238.6 3.8 -7 25 16 231.8 3.7 -7 17 24 219.5 3.9 -7 20 8 232.7 3.5 -7 22 24 187.4 3.8 -7 25 17 87.4 3.6 -7 17 25 198.3 6.8 -7 20 9 359.8 5.3 -7 22 25 58.5 7.7 -7 25 18 161.5 3.1 -7 17 26 209.2 4.7 -7 20 10 141.7 2.8 -7 22 26 64.0 7.5 -7 25 19 16.1 7.6 -7 17 27 289.4 4.5 -7 20 11 267.5 4.0 -7 22 27 38.9 12.6 -7 25 20 178.4 9.1 -7 17 28 241.2 4.5 -7 20 12 422.1 5.2 -7 22 28 148.6 4.5 -7 25 21 171.6 3.4 -7 17 29 106.3 5.5 -7 20 13 302.9 4.6 -7 23 1 383.4 6.5 -7 25 22 222.1 3.8 -7 17 30 33.0 12.9 -7 20 14 209.1 3.2 -7 23 2 61.8 6.7 -7 25 23 83.0 6.4 -7 18 1 405.4 9.0 -7 20 15 233.2 3.6 -7 23 3 360.6 5.3 -7 25 24 93.5 4.4 -7 18 2 232.4 7.9 -7 20 16 234.6 4.5 -7 23 4 161.2 3.1 -7 25 25 78.0 6.3 -7 18 3 483.9 6.9 -7 20 17 290.7 4.6 -7 23 5 192.7 3.3 -7 25 26 174.2 5.8 -7 18 4 583.9 7.1 -7 20 18 158.1 3.4 -7 23 6 233.1 3.3 -7 26 1 219.3 4.6 -7 18 5 787.9 10.9 -7 20 19 65.5 6.8 -7 23 7 477.1 6.2 -7 26 2 102.0 4.2 -7 18 6 835.7 13.2 -7 20 20 209.3 3.6 -7 23 8 158.0 2.7 -7 26 3 188.9 4.5 WO 99/10379 PCT/GB98/02542 -81 -7 26 4 15.1 6.9 -7 29 3 394.8 7.7 -7 32 10 186.5 3.1 -7 36 8 169.9 3.0 -7 26 5 147.3 2.5 -7 29 4 67.0 6.3 -7 32 11 219.0 6.6 -7 36 9 207.8 3.4 -7 26 6 225.1 3.3 -7 29 5 77.6 4.0 -7 32 12 189.1 3.7 -7 36 10 189.7 3.1 -7 26 7 349.7 4.4 -7 29 6 286.8 4.7 -7 32 13 130.6 3.9 -7 36 11 71.5 4.0 -7 26 8 112.5 2.5 -7 29 7 372.4 4.8 -7 32 14 38.1 7.9 -7 36 12 268.5 3.8 -7 26 9 83.5 3.5 -7 29 8 308.9 4.4 -7 32 15 59.2 5.3 -7 36 13 73.1 4.4 -7 26 10 112.0 2.6 -7 29 9 249.8 3.4 -7 32 16 174.7 3.1 -7 36 14 100.6 3.2 -7 26 11 102.7 2.7 -7 29 10 227.2 3.6 -7 32 17 89.9 5.7 -7 36 15 70.3 6.0 -7 26 12 13.7 6.7 -7 29 11 212.1 2.9 -7 32 18 117.6 3.4 -7 37 1 102.8 4.0 -7 26 13 189.1 2.9 -7 29 12 182.5 3.0 -7 32 19 135.1 3.4 -7 37 2 48.3 6.2 -7 26 14 120.6 3.0 -7 29 13 146.3 3.5 -7 32 20 23.8 9.9 -7 37 3 101.0 3.6 -7 26 15 158.2 2.8 -7 29 14 21.7 8.3 -7 33 1 68.1 4.8 -7 37 4 115.3 3.9 -7 26 16 75.4 4.2 -7 29 15 154.6 3.2 -7 33 2 59.3 6.2 -7 37 5 70.8 5.7 -7 26 17 206.8 3.5 -7 29 16 230.7 5.3 -7 33 3 365.1 7.2 -7 37 6 153.0 4.0 -7 26 18 13.0 6.5 -7 29 17 256.8 4.4 -7 33 4 148.9 3.5 -7 37 7 131.9 3.0 -7 26 19 232.4 6.8 -7 29 18 144.3 3.1 -7 33 5 191.6 4.2 -7 37 8 214.8 3.8 -7 26 20 122.2 4.2 -7 29 19 305.8 5.8 -7 33 6 33.3 7.2 -7 37 9 43.5 6.0 -7 26 21 278.6 4.5 -7 29 20 149.9 4.0 -7 33 7 235.1 3.4 -7 37 10 86.5 3.1 -7 26 22 238.9 4.1 -7 29 21 248.0 4.2 -7 33 8 154.9 4.4 -7 37 11 121.5 2.8 -7 26 23 227.0 4.5 -7 29 22 76.6 5.4 -7 33 9 241.7 7.1 -7 37 12 208.4 3.4 -7 26 24 253.9 4.5 -7 29 23 107.5 3.9 -7 33 10 119.8 3.2 -7 37 13 12.8 6.3 -7 26 25 144.2 5.1 -7 30 1 191.8 4.5 -7 33 11 316.2 4.3 -7 37 14 156.9 4.7 -7 27 1 310.5 6.6 -7 30 2 140.9 3.4 -7 33 12 288.2 4.1 -7 38 1 53.0 5.4 -7 27 2 234.4 4.9 -7 30 3 306.4 6.4 -7 33 13 48.7 5.4 -7 38 2 148.2 4.7 -7 27 3 303.7 5.7 -7 30 4 133.4 3.5 -7 33 14 157.4 3.5 -7 38 3 84.7 4.3 -7 27 4 209.3 3.7 -7 30 5 77.9 3.3 -7 33 15 74.7 3.4 -7 38 4 121.0 3.6 -7 27 5 195.9 4.1 -7 30 6 198.7 2.8 -7 33 16 72.3 4.6 -7 38 5 161.9 4.6 -7 27 6 82.6 2.6 -7 30 7 247.0 3.4 -7 33 17 192.1 3.3 -7 38 6 42.8 9.5 -7 27 7 37.9 5.7 -7 30 8 295.0 4.0 -7 33 18 68.8 5.2 -7 38 7 107.1 2.9 -7 27 8 192.7 2.6 -7 30 9 251.2 3.5 -7 33 19 118.0 3.2 -7 38 8 181.5 4.3 -7 27 9 144.7 2.5 -7 30 10 138.7 3.2 -7 34 1 160.8 4.0 -7 38 9 172.6 2.8 -7 27 10 167.2 2.6 -7 30 11 292.9 3.9 -7 34 2 14.5 7.1 -7 38 10 169.8 3.1 -7 27 11 40.9 7.4 -7 30 12 150.8 2.9 -7 34 3 159.5 4.2 -7 38 11 225.1 3.5 -7 27 12 49.2 4.4 -7 30 13 155.3 3.2 -7 34 4 13.5 6.8 -7 38 12 81.8 4.8 -7 27 13 175.1 2.8 -7 30 14 244.4 4.3 -7 34 5 118.3 6.6 -7 39 1 325.7 5.9 -7 27 14 67.1 4.9 -7 30 15 200.4 3.4 -7 34 6 257.7 6.5 -7 39 2 250.8 5.6 -7 27 15 283.9 4.0 -7 30 16 195.9 3.3 -7 34 7 149.6 3.7 -7 39 3 165.3 3.4 -7 27 16 163.0 2.9 -7 30 17 83.5 4.0 -7 34 8 89.2 3.1 -7 39 4 109.9 3.6 -7 27 17 181.5 3.0 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10.6 5.2 -7 31 11 68.3 4.2 -7 35 5 297.4 6.0 -6 0 4 340.8 7.2 -7 28 8 90.2 2.7 -7 31 12 165.4 3.1 -7 35 6 299.1 5.0 -6 0 5 42.6 5.8 -7 28 9 93.5 2.9 -7 31 13 154.3 7.9 -7 35 7 18.3 7.9 -6 0 6 563.1 14.7 -7 28 10 83.7 3.4 -7 31 14 206.1 3.2 -7 35 8 167.3 3.2 -6 0 7 274.7 5.9 -7 28 11 96.9 3.6 -7 31 15 237.9 3.4 -7 35 9 54.0 4.7 -6 0 8 26.8 10.6 -7 28 12 201.0 3.2 -7 31 16 200.9 4.1 -7 35 10 157.9 2.7 -6 0 9 16.4 9.4 -7 28 13 62.5 5.6 -7 31 17 141.7 3.2 -7 35 11 30.1 7.6 -6 0 10 7.2 5.3 -7 28 14 274.9 4.2 -7 31 18 125.5 4.0 -7 35 12 65.3 3.9 -6 0 11 328.4 6.1 -7 28 15 57.2 4.6 -7 31 19 60.1 6.6 -7 35 13 149.6 2.9 -6 0 12 42.3 15.0 -7 28 16 190.3 3.4 -7 31 20 133.4 4.4 -7 35 14 133.3 2.9 -6 0 13 79.9 5.1 -7 28 17 254.5 6.1 -7 31 21 141.3 3.8 -7 35 15 212.4 4.1 -6 0 14 75.2 7.4 -7 28 18 199.8 3.4 -7 32 1 120.2 3.5 -7 35 16 67.4 4.4 -6 0 15 163.2 10.6 -7 28 19 115.0 5.1 -7 32 2 147.6 3.5 -7 35 17 54.9 5.9 -6 0 16 342.1 7.0 -7 28 20 295.4 4.7 -7 32 3 97.6 3.7 -7 36 1 39.3 7.6 -6 0 17 90.7 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5 656.6 9.2 -5 18 15 89.6 3.5 -5 11 21 78.4 5.5 -5 13 29 223.5 4.9 -5 16 6 888.3 13.1 -5 18 16 318.7 4.3 -5 11 22 284.3 4.5 -5 13 30 83.1 10.3 -5 16 7 128.5 2.3 -5 18 17 196.8 3.4 -5 11 23 51.9 7.9 -5 13 31 61.4 12.9 -5 16 8 269.3 4.2 -5 18 18 171.3 3.1 -5 11 24 376.7 5.9 -5 13 32 105.3 7.7 -5 16 9 178.6 3.7 -5 18 19 76.3 4.4 -5 11 25 324.0 6.3 -5 14 1 240.1 6.3 -5 16 10 327.2 4.8 -5 18 20 103.5 4.4 -5 11 26 96.7 4.8 -5 14 2 390.5 5.3 -5 16 11 193.6 4.8 -5 18 21 255.2 3.6 -5 11 27 55.8 8.2 -5 14 3 873.0 13.8 -5 16 12 364.7 5.5 -5 18 22 191.5 3.9 -5 11 28 288.2 10.6 -5 14 4 707.9 9.5 -5 16 13 269.6 5.0 -5 18 23 252.5 4.5 -5 11 29 22.4 11.0 -5 14 5 371.0 4.5 -5 16 14 393.5 6.3 -5 18 24 110.5 4.8 -5 11 30 280.3 4.9 -5 14 6 701.7 10.0 -5 16 15 239.7 3.9 -5 18 25 100.9 7.2 -5 11 31 126.3 5.8 -5 14 7 389.6 5.5 -5 16 16 205.1 3.5 -5 18 26 164.5 5.2 -5 11 32 253.5 4.7 -5 14 8 259.9 3.4 -5 16 17 255.1 3.7 -5 18 27 283.0 4.4 -5 12 1 521.1 6.9 -5 14 9 926.3 15.8 -5 16 18 185.5 3.5 -5 18 28 62.8 11.5 -5 12 2 216.6 3.0 -5 14 10 914.2 12.6 -5 16 19 226.2 4.3 -5 18 29 42.2 12.7 -5 12 3 488.9 6.3 -5 14 11 453.8 7.9 -5 16 20 165.2 4.3 -5 18 30 113.2 5.6 -5 12 4 399.7 5.5 -5 14 12 35.2 8.9 -5 16 21 408.4 6.0 -5 19 1 228.4 6.4 -5 12 5 623.9 8.9 -5 14 13 494.3 7.0 -5 16 22 204.5 3.5 -5 19 2 474.9 7.4 -5 12 6 430.7 5.8 -5 14 14 523.9 9.4 -5 16 23 70.6 5.7 -5 19 3 290.1 6.7 -5 12 7 363.6 4.9 -5 14 15 58.0 5.5 -5 16 24 138.5 4.0 -5 19 4 434.9 5.6 -5 12 8 130.1 2.4 -5 14 16 257.0 4.6 -5 16 25 119.5 5.0 -5 19 5 155.2 2.9 -5 12 9 281.0 4.3 -5 14 17 219.0 3.6 -5 16 26 36.5 15.3 -5 19 6 18.3 8.3 -5 12 10 251.5 3.5 -5 14 18 215.8 3.6 -5 16 27 45.8 10.9 -5 19 7 480.9 6.8 -5 12 11 712.8 10.2 -5 14 19 302.4 4.4 -5 16 28 135.2 5.2 -5 19 8 58.8 4.6 -5 12 12 521.7 8.9 -5 14 20 197.5 3.5 -5 16 29 130.3 5.6 -5 19 9 429.1 6.1 -5 12 13 193.8 3.8 -5 14 21 148.8 3.2 -5 16 30 102.3 7.5 -5 19 10 519.5 8.0 -5 12 14 339.9 5.3 -5 14 22 100.8 4.5 -5 16 31 111.4 6.1 -5 19 11 65.1 4.1 -5 12 15 167.0 3.2 -5 14 23 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4.6 -5 19 25 384.7 11.2 -5 12 29 33.0 14.1 -5 15 5 340.0 4.6 -5 17 15 395.0 5.4 -5 19 26 160.6 4.1 -5 12 30 145.9 4.8 -5 15 6 563.9 8.6 -5 17 16 195.2 3.3 -5 19 27 90.1 5.8 -5 12 31 104.9 7.2 -5 15 7 251.1 3.6 -5 17 17 291.2 4.6 -5 19 28 81.6 11.3 -5 12 32 89.0 8.8 -5 15 8 362.2 4.8 -5 17 18 269.9 4.0 -5 19 29 279.4 5.0 -5 13 1 154.2 2.9 -5 15 9 605.1 9.3 -5 17 19 120.2 3.3 -5 19 30 33.2 14.0 -5 13 2 220.4 3.2 -5 15 10 217.7 3.6 -5 17 20 73.5 4.5 -5 20 1 521.9 10.0 -5 13 3 315.2 4.2 -5 15 11 553.6 7.7 -5 17 21 157.1 3.2 -5 20 2 11.5 5.7 -5 13 4 573.1 7.0 -5 15 12 298.9 5.5 -5 17 22 138.4 4.5 -5 20 3 373.1 5.3 -5 13 5 306.0 4.1 -5 15 13 103.6 4.0 -5 17 23 66.1 6.3 -5 20 4 237.5 3.9 -5 13 6 243.9 3.8 -5 15 14 666.2 10.1 -5 17 24 242.8 4.0 -5 20 5 302.6 4.4 -5 13 7 573.6 7.7 -5 15 15 659.6 9.4 -5 17 25 114.5 4.8 -5 20 6 185.9 3.0 -5 13 8 708.6 10.1 -5 15 16 216.4 3.6 -5 17 26 214.7 15.3 -5 20 7 426.9 7.4 -5 13 9 306.1 4.4 -5 15 17 328.1 5.3 -5 17 27 269.8 4.7 -5 20 8 102.8 3.3 -5 13 10 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11.8 -5 18 10 302.9 4.1 -5 20 22 99.0 4.1 -5 13 24 138.1 4.2 -5 16 1 218.2 3.7 -5 18 11 334.9 4.5 -5 20 23 352.5 5.8 WO 99/10379 PCT/GB98/02542 -88 -5 20 24 130.9 7.4 -5 23 10 391.4 5.3 -5 26 1 130.0 3.0 -5 28 21 39.4 11.2 -5 20 25 257.5 4.8 -5 23 11 244.7 3.3 -5 26 2 387.7 7.2 -5 28 22 186.6 3.8 -5 20 26 118.2 5.8 -5 23 12 249.9 4.2 -5 26 3 101.6 4.3 -5 28 23 229.6 3.9 -5 20 27 131.7 5.7 -5 23 13 306.0 4.3 -5 26 4 264.2 3.5 -5 28 24 75.2 6.4 -5 20 28 70.6 7.9 -5 23 14 12.9 6.1 -5 26 5 208.8 3.0 -5 28 25 146.9 4.7 -5 20 29 167.7 4.5 -5 23 15 377.5 5.1 -5 26 6 166.0 2.5 -5 29 1 99.0 3.1 -5 21 1 495.8 9.6 -5 23 16 185.3 3.0 -5 26 7 133.7 2.3 -5 29 2 154.5 3.3 -5 21 2 438.0 12.3 -5 23 17 272.9 4.1 -5 26 8 384.2 5.4 -5 29 3 402.2 8.1 -5 21 3 261.9 3.7 -5 23 18 125.1 3.0 -5 26 9 58.2 4.3 -5 29 4 201.8 3.2 -5 21 4 941.3 11.8 -5 23 19 297.5 5.9 -5 26 10 411.4 5.9 -5 29 5 110.5 2.4 -5 21 5 16.8 7.3 -5 23 20 126.5 4.1 -5 26 11 94.6 2.5 -5 29 6 282.7 3.8 -5 21 6 456.4 7.4 -5 23 21 134.1 3.8 -5 26 12 282.1 3.8 -5 29 7 108.7 2.1 -5 21 7 384.4 5.7 -5 23 22 81.9 6.5 -5 26 13 166.8 2.8 -5 29 8 117.1 2.5 -5 21 8 542.4 8.6 -5 23 24 57.7 8.5 -5 26 14 170.7 2.8 -5 29 9 159.0 2.8 -5 21 9 102.5 2.6 -5 23 25 195.5 4.0 -5 26 15 246.7 3.4 -5 29 10 73.7 3.3 -5 21 10 265.0 4.1 -5 23 26 179.2 5.1 -5 26 16 130.0 2.9 -5 29 12 76.9 3.6 -5 21 11 87.2 3.3 -5 23 27 149.9 5.7 -5 26 17 37.1 7.8 -5 29 13 212.2 3.8 -5 21 12 523.2 7.9 -5 23 28 166.3 4.9 -5 26 18 160.8 3.4 -5 29 14 46.0 7.2 -5 21 13 232.5 3.9 -5 24 1 358.6 6.8 -5 26 19 71.9 4.6 -5 29 15 81.9 5.6 -5 21 14 301.6 4.2 -5 24 2 98.7 3.1 -5 26 20 64.3 9.1 -5 29 16 157.7 3.1 -5 21 15 257.9 3.6 -5 24 3 62.8 3.3 -5 26 21 374.9 5.7 -5 29 17 162.7 4.4 -5 21 16 60.2 4.0 -5 24 4 242.0 3.7 -5 26 22 274.4 5.1 -5 29 18 124.2 4.0 -5 21 17 76.9 5.1 -5 24 5 275.1 4.0 -5 26 23 252.5 4.9 -5 29 19 114.9 4.4 -5 21 18 61.0 4.6 -5 24 6 57.6 3.1 -5 26 24 27.8 10.9 -5 29 20 121.1 4.0 -5 21 19 197.5 3.2 -5 24 7 583.6 8.8 -5 26 25 171.1 4.6 -5 29 21 76.1 5.6 -5 21 20 312.9 4.5 -5 24 8 91.8 3.3 -5 26 26 177.2 4.3 -5 29 22 130.5 4.3 -5 21 21 174.0 3.3 -5 24 9 300.7 4.0 -5 27 1 246.5 4.7 -5 29 23 63.3 8.6 -5 21 22 55.6 7.4 -5 24 10 114.2 2.6 -5 27 2 81.7 3.2 -5 29 24 193.4 3.8 -5 21 23 39.2 12.2 -5 24 11 335.7 4.3 -5 27 3 323.9 6.0 -5 30 1 165.1 3.1 -5 21 24 327.1 8.1 -5 24 12 35.1 6.6 -5 27 4 235.6 4.0 -5 30 2 154.2 3.1 -5 21 25 124.5 4.7 -5 24 13 146.8 2.6 -5 27 5 211.6 3.3 -5 30 3 28.2 7.9 -5 21 26 226.6 5.2 -5 24 14 160.9 3.1 -5 27 6 433.3 6.2 -5 30 4 169.8 3.7 -5 21 27 133.7 4.5 -5 24 15 408.3 5.8 -5 27 7 340.9 4.3 -5 30 5 153.8 2.4 -5 21 28 45.5 16.0 -5 24 16 71.8 4.4 -5 27 8 391.6 5.8 -5 30 6 66.8 2.9 -5 21 29 37.8 13.2 -5 24 17 347.0 4.9 -5 27 9 171.8 2.7 -5 30 7 130.7 2.1 -5 22 1 95.6 4.0 -5 24 18 238.9 3.6 -5 27 10 205.8 3.1 -5 30 8 147.4 2.8 -5 22 2 598.6 12.3 -5 24 19 19.6 8.3 -5 27 11 217.6 3.2 -5 30 9 213.9 3.1 -5 22 3 114.7 2.8 -5 24 20 77.4 4.9 -5 27 12 168.9 2.6 -5 30 10 107.7 2.4 -5 22 4 235.4 3.6 -5 24 21 15.6 7.6 -5 27 13 100.3 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33 10 105.1 2.4 -4 24 21 176.7 3.4 -4 27 11 59.1 4.1 -4 30 8 126.7 2.7 -4 33 11 207.0 3.3 -4 24 22 103.0 8.7 -4 27 12 57.9 4.1 -4 30 9 332.2 4.8 -4 33 12 55.0 6.1 -4 24 23 108.7 5.2 -4 27 13 370.2 5.9 -4 30 10 131.7 2.3 -4 33 13 157.3 6.9 -4 24 24 209.2 4.1 -4 27 14 97.3 3.8 -4 30 11 144.4 2.8 -4 33 14 95.1 3.7 -4 24 25 249.4 4.4 -4 27 15 386.5 6.7 -4 30 12 114.4 2.5 -4 33 15 76.0 7.1 -4 24 26 189.8 5.2 -4 27 16 135.6 3.0 -4 30 13 122.4 2.7 -4 33 16 80.5 5.5 -4 24 27 51.1 11.3 -4 27 17 292.9 4.5 -4 30 14 49.6 5.8 -4 33 17 17.7 8.7 -4 24 28 214.0 5.1 -4 27 18 166.1 3.6 -4 30 15 104.8 3.7 -4 33 18 136.4 4.0 WO 99/10379 PCT/GB98/02542 -93 -4 33 19 139.1 3.8 -4 38 7 142.6 2.8 -3 1 13 147.0 2.6 -3 3 17 634.6 9.0 -4 33 20 163.7 4.2 -4 38 8 16.9 6.9 -3 1 14 402.1 5.5 -3 3 18 779.4 13.0 -4 33 21 83.6 7.2 -4 38 9 124.4 2.4 -3 1 15 351.8 4.5 -3 3 19 392.2 5.8 -4 34 1 282.9 7.8 -4 38 10 79.3 3.3 -3 1 16 188.6 3.3 -3 3 20 314.2 5.1 -4 34 2 152.2 5.8 -4 38 11 46.6 4.2 -3 1 17 314.8 5.2 -3 3 21 107.0 6.0 -4 34 3 181.3 5.8 -4 38 12 29.9 8.9 -3 1 18 254.3 5.1 -3 3 22 109.0 5.2 -4 34 4 424.4 11.9 -4 38 13 180.5 3.0 -3 1 19 449.1 6.3 -3 3 23 141.3 4.6 -4 34 5 248.2 4.5 -4 38 14 305.4 4.1 -3 1 20 365.1 6.1 -3 3 24 205.0 3.8 -4 34 6 203.7 3.7 -4 38 15 245.1 6.3 -3 1 21 603.6 9.6 -3 3 25 265.7 4.6 -4 34 7 164.7 2.3 -4 39 5 117.4 4.6 -3 1 22 230.3 4.3 -3 3 26 112.6 5.0 -4 34 8 62.7 2.9 -4 39 6 86.0 5.0 -3 1 23 191.6 4.5 -3 3 27 214.0 3.8 -4 34 9 58.3 3.6 -4 39 7 70.6 3.7 -3 1 24 117.3 5.3 -3 3 28 232.7 4.1 -4 34 10 132.2 3.1 -4 39 8 143.2 2.9 -3 1 25 402.1 5.4 -3 3 29 44.7 14.4 -4 34 11 192.3 7.1 -4 39 9 76.3 2.8 -3 1 26 92.5 6.3 -3 3 31 159.4 5.2 -4 34 12 177.6 3.9 -4 39 10 105.2 2.7 -3 1 27 143.4 4.5 -3 3 32 52.0 13.6 -4 34 13 78.0 3.5 -4 39 11 27.6 8.3 -3 1 28 180.0 4.3 -3 3 33 74.6 8.8 -4 34 14 231.3 3.9 -4 39 12 199.4 3.9 -3 1 29 275.0 4.1 -3 3 34 55.2 15.4 -4 34 15 56.6 5.7 -4 39 13 97.9 4.5 -3 1 30 37.7 17.0 -3 4 1 754.6 24.0 -4 34 16 69.7 4.2 -4 40 6 122.3 5.1 -3 1 31 55.0 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12 227.4 4.5 0 12 21 171.5 3.8 0 6 1 295.8 6.8 0 8 7 210.2 3.4 0 10 13 232.5 4.8 0 12 22 139.8 4.7 0 6 2 530.7 10.2 0 8 8 507.1 7.8 0 10 14 526.9 8.5 0 12 23 187.4 5.1 0 6 3 671.8 13.8 0 8 9 111.7 2.8 0 10 15 668.4 11.6 0 12 24 333.9 5.0 0 6 4 835.7 13.4 0 8 10 258.4 4.0 0 10 16 1185.8 16.2 0 12 25 129.8 4.1 0 6 5 461.7 6.7 0 8 11 572.9 8.2 0 10 17 524.3 6.8 0 12 26 194.8 4.3 0 6 6 395.2 6.1 0 8 12 48.9 7.1 0 10 18 259.2 5.4 0 12 27 145.8 4.0 0 6 7 508.8 8.5 0 8 13 932.2 15.8 0 10 19 654.9 12.3 0 12 28 86.4 17.3 0 6 8 224.3 4.1 0 8 14 114.9 4.4 0 10 20 291.4 4.7 0 12 29 212.5 5.6 0 6 9 106.5 2.6 0 8 15 247.1 5.8 0 10 21 277.1 4.2 0 12 30 173.9 4.4 0 6 10 436.0 6.3 0 8 16 375.3 6.4 0 10 22 190.6 4.3 0 12 31 120.0 7.1 0 6 11 43.0 7.8 0 8 17 492.7 8.0 0 10 23 166.8 3.4 0 12 32 46.4 11.7 0 6 12 418.3 5.8 0 8 18 328.6 5.2 0 10 24 36.5 11.8 0 12 33 94.2 6.4 0 6 13 127.1 3.3 0 8 19 398.6 6.9 0 10 25 158.8 3.9 0 13 2 80.6 2.6 0 6 14 190.3 3.5 0 8 20 166.0 5.0 0 10 26 256.5 4.3 0 13 3 233.1 3.7 0 6 15 386.0 6.6 0 8 21 281.2 4.5 0 10 27 211.2 4.3 0 13 4 326.4 4.9 0 6 16 495.0 8.1 0 8 22 374.3 5.2 0 10 28 194.1 4.6 0 13 5 278.6 4.6 0 6 17 324.7 7.1 0 8 23 297.9 4.5 0 10 29 250.4 9.7 0 13 6 448.3 5.9 0 6 18 435.7 8.8 0 8 24 412.3 6.4 0 10 30 39.4 14.2 0 13 7 84.3 2.7 0 6 19 465.4 7.6 0 8 25 282.4 4.3 0 10 31 43.6 13.6 0 13 8 609.5 8.1 0 6 20 417.9 7.8 0 8 26 180.7 4.5 0 10 32 96.0 8.7 0 13 9 294.5 4.5 0 6 21 238.7 5.9 0 8 27 272.3 5.3 0 10 33 165.8 5.3 0 13 10 331.6 4.5 0 6 22 432.5 6.9 0 8 28 94.4 7.8 0 11 2 109.4 2.1 0 13 11 405.3 5.6 0 6 23 200.2 3.9 0 8 29 168.3 13.7 0 11 3 482.9 6.8 0 13 12 508.7 7.3 0 6 24 75.5 6.4 0 8 30 247.5 5.0 0 11 4 106.5 1.8 0 13 13 526.6 7.5 0 6 25 63.2 7.7 0 8 31 171.9 5.3 0 11 5 84.9 2.0 0 13 14 187.3 4.5 0 6 26 51.9 10.7 0 8 32 112.5 5.6 0 11 6 446.7 7.0 0 13 15 206.2 4.9 0 6 27 113.5 5.5 0 8 33 61.0 10.9 0 11 7 203.8 3.0 0 13 16 175.5 3.6 0 6 28 155.5 5.0 0 9 1 104.8 5.0 0 11 8 431.8 5.9 0 13 17 796.7 14.8 0 6 29 170.8 5.5 0 9 2 565.5 7.9 0 11 9 486.3 6.6 0 13 18 721.0 11.6 0 6 30 62.7 9.9 0 9 3 194.4 3.2 0 11 10 259.8 4.5 0 13 19 293.9 4.7 0 6 31 99.9 6.4 0 9 4 381.3 5.4 0 11 11 688.2 12.0 0 13 20 393.1 6.3 0 6 32 147.7 5.4 0 9 5 215.0 3.6 0 11 12 203.4 3.8 0 13 21 156.7 4.8 0 6 33 67.8 10.8 0 9 6 299.1 4.7 0 11 13 303.9 5.0 0 13 22 192.0 3.7 0 6 34 119.7 5.9 0 9 7 178.3 3.4 0 11 14 645.5 11.2 0 13 23 80.4 6.0 0 7 1 422.9 10.1 0 9 8 553.4 9.4 0 11 15 288.8 5.1 0 13 24 194.0 4.3 0 7 2 437.1 8.0 0 9 9 379.5 7.1 0 11 16 457.7 6.6 0 13 25 234.9 4.5 0 7 3 288.9 4.8 0 9 10 374.7 6.9 0 11 17 670.7 10.4 0 13 26 192.7 4.2 0 - 4 508.6 6.7 0 9 11 501.6 7.6 0 11 18 180.9 4.2 0 13 27 70.3 7.9 0 7 5 202.1 3.1 0 9 12 315.4 5.5 0 11 19 204.8 4.6 0 13 28 334.2 7.4 0 7 6 257.0 3.4 0 9 13 273.1 4.3 0 11 20 198.6 3.8 0 13 29 178.8 4.1 0 7 7 638.4 8.1 0 9 14 444.4 7.0 0 11 21 113.3 4.3 0 13 30 169.7 4.9 0 7 8 49.8 4.0 0 9 15 305.1 5.9 0 11 22 62.4 11.4 0 13 31 269.6 4.7 0 7 9 492.1 6.5 0 9 16 598.9 9.9 0 11 23 167.1 3.5 0 13 32 108.0 6.7 0 7 10 222.3 3.2 0 9 17 366.6 8.9 0 11 24 126.8 4.3 0 14 2 160.8 2.8 0 7 11 506.4 8.1 0 9 18 193.2 3.9 0 11 25 197.7 4.4 0 14 3 302.0 3.7 0 7 12 591.6 9.1 0 9 19 452.4 8.5 0 11 26 74.6 7.2 0 14 4 269.4 3.6 0 7 13 359.0 5.3 0 9 20 306.9 5.5 0 11 27 34.6 11.5 0 14 5 128.3 2.5 0 7 14 292.2 5.3 0 9 21 419.9 7.1 0 11 28 22.5 10.2 0 14 6 816.6 12.7 0 7 15 436.7 7.0 0 9 22 325.0 6.4 0 11 30 266.2 4.8 0 14 7 382.5 7.1 0 7 16 387.0 6.0 0 9 23 86.0 5.1 0 11 31 32.8 13.3 0 14 8 392.3 5.4 0 7 17 296.9 4.5 0 9 24 420.0 6.1 0 11 32 94.8 9.7 0 14 9 974.8 13.1 0 7 18 466.4 6.7 0 9 25 109.7 6.2 0 11 33 37.5 12.1 0 14 10 602.7 7.4 0 7 19 188.5 4.5 0 9 26 100.8 4.6 0 12 2 353.0 4.6 0 14 11 532.8 9.1 0 7 20 356.9 6.3 0 9 27 297.8 5.4 0 12 3 419.8 5.7 0 14 12 277.6 4.1 0 7 21 204.7 4.7 0 9 28 160.0 5.6 0 12 4 588.6 7.8 0 14 13 622.6 9.0 0 7 22 187.7 5.7 0 9 29 286.4 8.6 0 12 5 374.9 5.0 0 14 14 438.8 6.9 0 7 23 48.1 15.4 0 9 30 201.3 5.0 0 12 6 510.4 7.2 0 14 15 278.2 4.2 0 7 24 275.3 4.4 0 9 31 168.9 4.6 0 12 7 507.4 7.2 0 14 16 476.7 7.9 WO 99/10379 PCT/GB98/02542 -106 0 14 17 270.5 4.7 0 16 27 303.5 9.5 0 19 12 260.6 4.7 0 21 27 117.8 4.9 0 14 18 481.3 6.8 0 16 28 163.2 4.4 0 19 13 376.0 5.8 0 21 28 123.2 5.0 0 14 19 232.0 3.9 0 16 29 133.0 4.9 0 19 14 218.6 4.3 0 21 29 135.0 7.1 0 14 20 196.0 4.2 0 16 30 154.8 4.2 0 19 15 334.3 4.7 0 21 30 73.6 7.5 0 14 21 252.1 4.8 0 16 31 163.2 4.7 0 19 16 317.0 4.8 0 22 3 169.9 7.3 0 14 22 260.4 4.6 0 17 3 219.1 2.8 0 19 17 98.0 3.9 0 22 4 324.4 4.9 0 14 23 69.4 7.3 0 17 4 165.1 2.1 0 19 18 139.9 3.3 0 22 5 214.5 3.4 0 14 24 260.5 4.4 0 17 5 842.1 10.8 0 19 19 110.4 4.0 0 22 6 245.2 3.4 0 14 25 217.4 4.4 0 17 6 297.6 3.8 0 19 20 177.7 3.9 0 22 7 700.2 9.0 0 14 26 281.9 5.2 0 17 7 244.7 4.0 0 19 21 252.6 3.7 0 22 8 211.1 3.1 0 14 27 158.4 4.4 0 17 8 860.1 12.1 0 19 22 64.2 5.9 0 22 9 477.9 6.8 0 14 28 21.4 10.7 0 17 9 280.2 4.0 0 19 23 69.4 6.1 0 22 10 228.6 3.8 0 14 29 77.3 6.3 0 17 10 240.1 5.4 0 19 24 159.6 3.5 0 22 11 381.8 5.0 0 14 30 133.2 5.4 0 17 11 218.0 3.9 0 19 25 66.1 6.3 0 22 12 276.5 4.0 0 14 31 308.8 5.1 0 17 12 462.1 6.0 0 19 26 87.1 8.9 0 22 13 368.9 5.7 0 14 32 139.0 4.9 0 17 13 226.8 3.5 0 19 27 98.5 6.1 0 22 14 274.6 4.4 0 15 1 157.0 5.6 0 17 14 271.5 5.1 0 19 28 96.0 7.6 0 22 15 342.6 5.1 0 15 2 522.4 13.4 0 17 15 410.7 7.9 0 19 29 20.6 9.9 0 22 16 497.1 8.4 0 15 3 318.0 4.6 0 17 16 425.6 6.5 0 19 30 200.0 5.0 0 22 17 81.9 3.7 0 15 4 236.2 2.9 0 17 17 417.1 7.5 0 20 2 151.3 6.5 0 22 18 68.3 4.3 0 15 5 202.3 2.9 0 17 18 140.8 3.7 0 20 3 186.4 4.8 0 22 19 224.8 3.5 0 15 6 667.0 9.1 0 17 19 399.5 6.4 0 20 4 452.1 5.5 0 22 20 116.5 3.3 0 15 7 143.3 2.9 0 17 20 172.8 3.6 0 20 5 467.5 6.4 0 22 21 101.4 3.7 0 15 8 735.4 13.6 0 17 21 275.3 4.1 0 20 6 365.0 4.9 0 22 22 239.1 3.7 0 15 9 113.5 2.8 0 17 22 198.5 3.3 0 20 7 431.1 6.0 0 22 23 241.5 4.1 0 15 10 604.0 8.9 0 17 23 70.8 6.4 0 20 8 253.3 3.5 0 22 24 309.6 17.9 0 15 11 273.4 4.2 0 17 24 94.0 4.4 0 20 9 361.8 5.1 0 22 25 167.0 4.0 0 15 12 910.4 12.6 0 17 25 65.6 6.5 0 20 10 168.5 2.8 0 22 26 105.7 5.9 0 15 13 800.3 11.9 0 17 26 87.5 7.9 0 20 11 527.1 8.1 0 22 27 106.6 6.3 0 15 14 419.9 5.6 0 17 27 48.8 11.8 0 20 12 326.5 5.3 0 22 28 148.7 4.1 0 15 15 396.0 5.1 0 17 28 13.6 6.9 0 20 13 107.2 4.0 0 22 29 56.7 9.3 0 15 16 424.1 6.2 0 17 29 95.7 6.0 0 20 14 204.7 5.1 0 23 4 223.6 7.6 0 15 17 179.4 4.7 0 17 30 24.0 11.8 0 20 15 74.3 4.0 0 23 5 161.5 2.4 0 15 18 162.8 3.8 0 17 31 32.5 12.3 0 20 16 200.8 3.7 0 23 6 284.5 3.8 0 15 19 180.9 3.6 0 18 3 543.4 9.0 0 20 17 219.5 3.7 0 23 7 227.6 3.2 0 15 20 165.7 3.6 0 18 4 766.4 9.4 0 20 18 244.0 4.4 0 23 8 21.7 7.8 0 15 21 206.1 3.3 0 18 5 920.7 11.8 0 20 19 197.4 3.3 0 23 9 313.0 5.3 0 15 22 341.8 4.9 0 18 6 1453.7 30.9 0 20 20 149.0 3.3 0 23 10 244.8 3.6 0 15 23 237.2 3.9 0 18 7 454.7 6.6 0 20 21 137.9 3.2 0 23 11 96.8 2.9 0 15 24 162.4 3.5 0 18 8 318.9 4.3 0 20 22 42.0 8.3 0 23 12 263.6 4.0 0 15 25 283.2 5.0 0 18 9 64.1 5.3 0 20 23 140.0 3.5 0 23 13 123.8 2.7 0 15 26 195.1 5.4 0 18 10 113.4 2.9 0 20 24 342.3 4.8 0 23 14 368.1 5.4 0 15 27 108.8 5.5 0 18 11 105.4 5.1 0 20 25 128.4 12.0 0 23 15 203.3 3.1 0 15 28 188.1 4.1 0 18 12 240.7 3.8 0 20 26 158.7 4.7 0 23 16 155.8 2.8 0 15 29 153.2 4.6 0 18 13 546.4 7.8 0 20 27 136.6 4.0 0 23 17 237.4 4.1 0 15 30 178.6 4.3 0 18 14 332.1 4.7 0 20 28 255.1 4.7 0 23 18 21.6 8.9 0 15 31 62.6 8.1 0 18 15 302.0 4.5 0 20 29 134.3 4.8 0 23 19 176.1 3.0 0 16 2 178.0 5.3 0 18 16 191.2 3.5 0 20 30 155.5 5.1 0 23 20 96.7 3.7 0 16 3 214.4 2.8 0 18 17 342.8 6.2 0 21 3 67.4 4.5 0 23 21 93.0 4.2 0 16 4 576.5 8.3 0 18 18 176.7 3.4 0 21 4 396.6 5.1 0 23 22 194.4 3.4 0 16 5 176.8 2.6 0 18 19 446.5 6.2 0 21 5 198.8 2.8 0 23 23 126.0 4.0 0 16 6 293.6 4.0 0 18 20 110.5 3.6 0 21 6 100.7 2.3 0 23 24 293.3 5.6 0 16 7 293.0 4.8 0 18 21 326.1 4.6 0 21 7 428.2 5.4 0 23 25 143.0 3.6 0 16 8 176.3 3.0 0 18 22 155.9 3.4 0 21 8 475.2 7.2 0 23 26 276.3 4.9 0 16 9 447.2 6.2 0 18 23 217.1 3.7 0 21 9 408.8 5.2 0 23 27 26.3 11.7 0 16 10 739.5 11.4 0 18 24 54.3 9.0 0 21 10 493.9 7.6 0 23 28 130.7 4.6 0 16 11 241.3 4.0 0 18 25 91.2 6.0 0 21 11 97.1 3.2 0 23 29 71.4 10.4 0 16 12 194.4 3.9 0 18 26 170.0 12.1 0 21 12 541.0 7.9 0 24 5 326.6 4.5 0 16 13 227.7 5.1 0 18 27 322.4 5.4 0 21 13 14.1 6.8 0 24 6 147.5 2.3 0 16 14 200.6 3.7 0 18 28 201.0 4.3 0 21 14 186.9 3.3 0 24 7 386.9 4.9 0 16 15 489.4 7.8 0 18 29 160.2 4.8 0 21 15 273.6 3.8 0 24 8 479.0 6.9 0 16 16 723.9 10.6 0 18 30 105.8 7.9 0 21 16 183.9 3.2 0 24 9 413.2 5.8 0 16 17 123.9 6.1 0 18 31 126.5 5.0 0 21 17 294.9 4.3 0 24 10 263.5 4.5 0 16 18 127.3 6.1 0 19 3 619.2 9.5 0 21 18 405.4 5.5 0 24 11 284.5 4.0 0 16 19 328.2 4.5 0 19 4 497.9 7.3 0 21 19 240.0 3.5 0 24 12 166.9 3.0 0 16 20 131.6 3.8 0 19 5 394.1 4.8 0 21 20 272.0 4.0 0 24 13 376.4 5.5 0 16 21 208.9 4.4 0 19 6 296.1 4.1 0 21 21 278.0 4.1 0 24 14 222.7 3.3 0 16 22 293.4 4.6 0 19 7 334.2 4.6 0 21 22 391.9 5.4 0 24 15 240.0 3.6 0 16 23 115.1 4.6 0 19 8 425.5 6.4 0 21 23 127.4 5.0 0 24 16 287.5 4.2 0 16 24 77.0 6.3 0 19 9 670.8 8.4 0 21 24 90.2 4.7 0 24 17 218.7 3.3 0 16 25 190.8 4.4 0 19 10 301.4 4.8 0 21 25 20.0 9.6 0 24 18 203.4 3.3 0 16 26 96.8 6.0 0 19 11 455.3 6.6 0 21 26 113.6 4.4 0 24 19 236.5 3.5 WO 99/10379 PCT/GB98/02542 -107 0 24 20 107.1 4.3 0 27 22 51.0 9.3 0 31 13 178.7 2.9 0 35 18 151.4 3.4 0 24 21 18.6 8.5 0 27 23 135.5 4.0 0 31 14 98.6 3.0 0 35 19 62.4 5.8 0 24 22 129.6 3.7 0 27 25 269.1 4.1 0 31 15 251.7 3.4 0 36 7 85.5 7.0 0 24 23 239.2 11.9 0 27 26 238.1 4.5 0 31 16 91.1 5.3 0 36 8 230.0 6.3 0 24 24 80.7 5.9 0 28 3 9.4 1.8 0 31 17 419.0 6.6 0 36 9 71.6 3.6 0 24 25 178.6 3.6 0 28 6 300.7 5.7 0 31 18 141.2 4.1 0 36 10 57.6 3.3 0 24 26 78.7 6.5 0 28 7 214.0 2.9 0 31 19 248.3 5.1 0 36 11 65.7 3.0 0 24 27 34.4 11.8 0 28 8 394.2 5.2 0 31 20 59.0 5.9 0 36 12 142.2 2.7 0 24 28 82.3 6.4 0 28 9 168.1 2.8 0 31 21 148.3 3.4 0 36 13 178.5 3.2 0 25 5 456.8 8.3 0 28 10 204.0 2.8 0 31 22 91.4 4.8 0 36 14 134.2 2.8 0 25 6 500.0 7.0 0 28 11 122.5 2.5 0 31 23 114.4 3.9 0 36 15 58.0 5.2 0 25 7 39.2 4.6 0 28 12 346.3 4.9 0 32 4 4.2 1.5 0 36 16 105.0 3.5 0 25 8 234.5 3.3 0 28 13 244.2 3.3 0 32 6 126.7 3.6 0 36 17 164.1 3.5 0 25 9 240.4 3.4 0 28 14 243.0 3.5 0 32 7 53.5 2.5 0 36 18 39.3 10.1 0 25 10 350.5 4.7 0 28 15 161.1 3.2 0 32 8 294.4 3.7 0 37 8 133.9 4.4 0 25 11 395.9 5.9 0 28 16 166.6 3.0 0 32 9 183.7 2.5 0 37 9 102.4 2.4 0 25 12 260.1 4.2 0 28 17 150.9 3.2 0 32 10 246.7 3.3 0 37 10 245.5 4.0 0 25 13 132.8 2.6 0 28 18 280.3 5.0 0 32 11 171.9 2.7 0 37 11 144.4 2.4 0 25 14 111.3 2.9 0 28 19 112.5 4.0 0 32 12 455.1 6.3 0 37 12 234.5 3.9 0 25 15 184.4 3.2 0 28 20 158.7 14.7 0 32 13 264.9 3.5 0 37 13 142.0 3.2 0 25 16 89.0 3.3 0 28 21 201.1 3.6 0 32 14 53.0 6.3 0 37 14 170.8 3.5 0 25 17 145.2 2.9 0 28 22 167.1 3.8 0 32 15 69.6 9.6 0 37 15 136.6 2.9 0 25 18 348.4 5.0 0 28 23 107.1 7.4 0 32 16 228.7 4.2 0 37 16 87.9 3.8 0 25 19 72.1 4.3 0 28 24 191.3 4.1 0 32 17 103.4 3.8 0 37 17 12.4 6.1 0 25 20 103.2 4.1 0 28 25 259.7 4.6 0 32 18 187.3 3.9 0 38 8 55.1 3.0 0 25 21 396.1 7.0 0 28 26 46.2 12.0 0 32 19 124.9 4.8 0 38 9 163.7 3.7 0 25 22 187.8 7.6 0 29 5 444.1 10.4 0 32 20 274.5 4.4 0 38 10 27.9 6.4 0 25 23 187.8 3.6 0 29 6 102.1 2.6 0 32 21 124.8 3.6 0 38 11 83.7 2.9 0 25 24 135.0 4.1 0 29 7 264.2 4.0 0 32 22 89.2 4.9 0 38 12 70.0 4.2 0 25 25 77.3 5.8 0 29 8 131.5 2.1 0 33 7 176.4 3.8 0 38 13 70.7 3.5 0 25 26 175.2 4.0 0 29 9 153.9 2.3 0 33 8 235.2 3.5 0 38 14 110.5 3.0 0 25 27 78.7 6.0 0 29 10 93.8 2.4 0 33 9 93.3 2.1 0 38 15 111.9 2.8 0 26 5 431.3 7.1 0 29 11 324.5 4.2 0 33 10 117.2 2.4 0 38 16 148.9 4.7 0 26 6 427.7 6.4 0 29 12 293.7 4.0 0 33 11 53.5 3.4 0 39 9 176.8 3.9 0 26 7 61.5 3.5 0 29 13 186.8 2.8 0 33 12 42.9 5.5 0 39 10 146.9 3.0 0 26 8 194.6 2.9 0 29 14 67.0 3.6 0 33 13 136.8 3.1 0 39 11 61.4 3.1 0 26 9 137.8 2.3 0 29 15 140.6 2.8 0 33 14 204.8 5.4 0 39 12 66.3 3.8 0 26 10 374.5 5.4 0 29 16 234.8 3.7 0 33 15 263.3 4.1 0 39 13 90.5 2.8 0 26 11 278.4 3.6 0 29 17 309.5 5.6 0 33 16 40.7 7.3 0 39 14 132.0 3.7 0 26 12 299.8 5.3 0 29 18 269.1 4.3 0 33 17 257.9 3.9 0 40 9 75.6 4.1 0 26 13 48.8 5.8 0 29 19 328.4 8.6 0 33 18 205.1 3.7 0 40 10 205.6 4.3 0 26 14 254.2 4.3 0 29 20 181.2 3.9 0 33 19 177.3 3.6 0 40 11 247.1 4.2 0 26 15 316.8 4.8 0 29 21 53.8 8.2 0 33 20 100.7 4.2 0 40 12 151.0 3.5 0 26 16 142.0 2.9 0 29 22 126.4 3.7 0 33 21 115.2 4.1 0 41 9 241.2 8.9 0 26 17 89.4 4.1 0 29 23 67.2 7.2 0 33 22 207.7 4.7 0 41 10 30.9 8.3 0 26 18 44.2 6.7 0 29 24 123.7 4.3 0 34 7 120.0 2.5 1 0 2 30.3 4.0 0 26 19 276.1 4.0 0 29 25 151.0 3.9 0 34 8 56.5 2.5 1 0 4 415.9 11.0 0 26 20 40.4 10.0 0 30 6 314.7 5.8 0 34 9 29.8 6.3 1 0 5 110.9 3.8 0 26 21 216.7 4.3 0 30 7 74.2 1.9 0 34 10 159.6 3.2 1 0 6 646.2 14.3 0 26 22 80.8 5.9 0 30 8 137.3 2.0 0 34 11 25.8 7.8 1 0 7 506.8 14.4 0 26 23 211.6 4.2 0 30 9 49.1 3.1 0 34 12 190.7 7.1 1 0 8 147.7 4.6 0 26 24 184.6 4.4 0 30 10 154.4 2.2 0 34 13 285.2 4.7 1 0 9 147.2 4.1 0 26 25 122.2 5.3 0 30 11 112.4 2.7 0 34 14 24.2 8.7 1 0 10 93.7 4.8 0 26 26 220.9 5.0 0 30 12 145.9 3.0 0 34 15 233.3 3.6 1 0 11 560.0 12.9 0 26 27 179.9 3.9 0 30 13 111.6 3.0 0 34 16 117.0 3.9 1 0 12 58.9 9.1 0 27 5 282.0 5.7 0 30 14 89.0 4.0 0 34 17 209.3 3.7 1 0 13 10.4 7.7 0 27 6 398.6 5.5 0 30 15 67.5 5.0 0 34 18 66.1 5.4 1 0 14 324.3 6.1 0 27 7 500.5 6.2 0 30 16 67.7 3.8 0 34 19 155.5 3.6 1 0 15 150.4 5.7 0 27 8 60.9 2.7 0 30 18 168.5 7.6 0 34 20 270.8 4.3 1 0 16 390.5 7.7 0 27 9 301.8 4.0 0 30 19 135.0 3.3 0 34 21 45.7 15.2 1 0 17 216.0 14.5 0 27 10 42.7 4.8 0 30 20 150.9 3.5 0 35 6 16.1 5.1 1 0 18 518.6 9.5 0 27 11 306.2 4.2 0 30 21 233.6 4.2 0 35 7 157.9 4.1 1 0 19 44.9 22.0 0 27 12 254.5 3.6 0 30 22 180.0 3.7 0 35 8 50.3 3.7 1 0 20 114.7 6.2 0 27 13 152.0 2.6 0 30 23 153.8 3.5 0 35 9 219.6 3.5 1 0 21 193.7 6.0 0 27 14 207.2 3.1 0 30 24 100.7 5.5 0 35 10 139.2 6.1 1 0 22 375.3 8.3 0 27 15 109.4 2.9 0 31 6 136.4 2.9 0 35 11 326.3 5.6 1 0 23 70.4 15.7 0 27 16 291.8 3.8 0 31 7 149.4 2.1 0 35 12 187.9 3.1 1 0 24 396.2 8.3 0 27 17 87.4 3.7 0 31 8 38.0 4.5 0 35 13 305.9 4.5 1 0 25 118.3 6.6 0 27 18 113.4 3.4 0 31 9 17.6 7.1 0 35 14 212.0 3.5 1 0 26 146.2 5.9 0 27 19 253.4 3.8 0 31 10 219.0 3.2 0 35 15 39.3 7.4 1 0 27 96.5 9.4 0 27 20 246.5 4.0 0 31 11 240.0 3.1 0 35 16 112.8 3.4 1 0 28 98.8 10.6 0 27 21 200.8 4.4 0 31 12 195.7 2.9 0 35 17 95.0 3.6 1 0 29 56.6 15.8 WO 99/10379 PCT/GB98/02542 -108 1 0 30 166.9 15.6 I 3 4 449.3 8.4 1 5 11 336.8 5.1 1 7 16 214.2 7.8 1 0 31 69.5 18.4 1 3 5 450.5 7.1 1 5 12 174.5 3.2 1 7 17 665.7 9.2 1 0 32 81.2 17.8 1 3 6 613.1 10.0 1 5 13 477.7 6.3 1 7 18 313.9 5.0 1 0 33 41.7 19.9 I 3 7 589.7 8.5 1 5 14 555.1 7.2 1 7 19 390.6 5.9 1 0 34 19.3 14.1 1 3 8 27.6 8.3 1 5 15 191.4 3.7 I 7 20 142.9 4.3 1 1 2 18.8 3.4 1 3 9 537.7 8.3 1 5 16 689.9 10.9 1 7 21 172.6 4.9 1 1 4 341.3 6.3 1 3 10 457.3 6.8 1 5 17 208.3 5.0 1 7 22 124.6 4.5 1 1 5 481.3 8.0 1 3 11 202.6 3.1 1 5 18 368.3 5.5 1 7 23 230.6 4.0 1 1 6 250.5 5.0 1 3 12 313.1 4.2 1 5 19 295.0 5.5 1 7 24 125.6 4.5 1 1 7 219.9 4.0 1 3 13 651.2 9.3 1 5 20 274.7 4.4 1 7 25 177.2 5.2 1 1 8 382.9 5.5 1 3 14 414.8 5.9 1 5 21 380.0 5.5 1 7 26 222.0 4.0 1 1 9 265.6 4.0 1 3 15 78.7 4.5 1 5 22 290.6 5.8 1 7 27 66.3 9.3 1 1 10 69.8 3.6 1 3 16 168.1 4.0 1 5 23 109.2 5.1 1 7 28 150.1 4.4 1 1 11 182.4 3.1 1 3 17 474.1 7.6 1 5 24 91.3 5.0 1 7 29 162.8 16.3 1 1 12 170.6 3.1 1 3 18 346.4 5.9 1 5 25 156.9 4.8 1 7 30 58.0 13.1 1 1 13 545.9 7.4 1 3 19 211.5 4.2 1 5 26 96.5 6.2 1 7 31 101.0 9.8 1 1 14 219.4 3.5 1 3 20 132.2 5.2 1 5 27 87.9 6.4 1 7 32 147.5 5.8 1 1 15 381.2 4.8 1 3 21 123.9 6.1 1 5 28 156.1 4.7 1 7 33 147.9 6.0 1 1 16 133.0 4.0 1 3 22 119.7 4.9 1 5 29 91.6 12.8 1 8 0 359.8 11.7 1 1 17 252.9 7.7 1 3 23 230.5 5.1 1 5 30 27.1 12.4 1 8 1 436.8 8.9 1 1 18 273.5 7.1 1 3 24 86.3 6.1 1 5 31 40.5 14.0 1 8 2 627.0 8.1 1 1 19 103.0 5.2 1 3 25 107.0 5.6 1 5 32 241.2 5.8 1 8 3 509.4 8.3 1 1 20 263.2 4.9 1 3 26 102.6 5.0 1 5 33 235.3 5.0 1 8 4 298.8 4.4 1 1 21 551.6 7.8 1 3 27 127.6 4.7 1 5 34 82.2 10.6 1 8 5 223.2 3.0 1 1 22 284.0 4.7 1 3 28 141.7 6.1 1 6 0 300.2 8.6 1 8 6 311.8 5.0 1 1 23 214.7 4.3 1 3 29 66.1 9.1 1 6 1 426.1 7.8 1 8 7 654.5 9.4 1 1 24 286.6 5.3 1 3 31 150.9 5.4 1 6 2 186.6 2.9 1 8 8 253.1 4.0 1 1 25 161.5 4.3 1 3 32 65.7 12.6 1 6 3 648.5 26.2 1 8 9 143.4 2.7 1 1 26 147.3 4.0 1 3 33 190.6 4.7 1 6 4 241.7 4.7 1 8 10 613.5 9.0 1 1 27 43.9 11.7 1 3 34 60.8 13.4 1 6 5 839.5 14.0 1 8 11 159.8 3.0 1 1 28 31.1 13.2 1 4 2 294.9 10.9 1 6 6 628.9 8.3 1 8 12 785.7 12.1 1 1 29 115.0 6.7 1 4 3 134.9 3.1 1 6 7 389.7 5.6 1 8 13 335.3 5.0 1 1 30 169.6 7.8 1 4 4 442.5 7.1 1 6 8 451.3 6.9 1 8 14 272.1 4.0 1 1 31 104.6 10.0 1 4 5 510.3 9.3 1 6 9 338.6 5.2 1 8 15 532.4 7.7 1 1 32 96.7 8.4 1 4 6 168.8 3.2 1 6 10 97.3 3.1 1 8 16 211.7 6.1 1 1 33 79.1 9.4 1 4 7 428.6 6.4 1 6 11 212.8 3.4 1 8 17 430.5 6.3 1 1 34 222.4 5.2 1 4 8 227.9 3.3 1 6 12 371.8 5.5 1 8 18 262.1 4.9 1 2 0 18.3 7.1 1 4 9 99.7 2.7 1 6 13 690.0 10.0 1 8 19 763.8 11.8 1 2 1 17.4 5.0 1 4 10 95.5 3.2 1 6 14 446.0 6.1 1 8 20 245.2 5.5 1 2 4 300.5 5.5 1 4 11 154.0 3.0 1 6 15 708.7 8.6 1 8 21 255.6 4.5 1 2 5 489.7 8.5 1 4 12 184.0 3.2 1 6 16 353.2 5.3 1 8 22 210.2 4.1 1 2 6 328.6 6.4 1 4 13 278.1 4.1 1 6 17 196.4 4.1 1 8 23 280.5 4.3 1 2 7 137.1 2.3 1 4 14 429.6 6.0 1 6 18 323.0 4.8 1 8 24 94.2 5.3 1 2 8 176.2 3.3 1 4 15 396.4 6.0 1 6 19 307.8 4.9 1 8 25 215.3 4.7 1 2 9 378.8 5.4 1 4 16 498.6 7.4 1 6 20 188.0 4.0 1 8 26 206.4 4.2 1 2 10 470.4 7.3 1 4 17 426.9 6.6 1 6 21 173.7 4.2 1 8 27 183.7 4.7 1 2 11 187.9 3.2 1 4 18 330.7 6.2 16 22 268.0 4.5 18 28 148.0 7.3 1 2 12 573.5 7.9 1 4 19 429.5 6.7 1 6 23 208.5 4.5 1 8 29 413.4 12.4 1 2 13 373.6 5.4 1 4 20 367.5 5.7 1 6 24 149.4 4.6 1 8 30 49.8 13.8 1 2 14 20.0 8.9 1 4 21 608.7 8.1 1 6 25 243.8 4.1 1 8 31 185.9 4.7 1 2 15 167.2 4.0 1 4 22 236.9 4.4 16 26 155.5 3.9 1 8 32 24.4 11.2 1 2 16 299.6 4.5 1 4 23 284.0 5.8 1 6 27 23.4 10.5 1 9 0 303.7 6.5 1 2 17 505.7 7.4 1 4 24 93.4 5.7 1 6 28 135.4 4.9 1 9 1 206.1 2.7 1 2 18 497.4 6.8 1 4 25 237.3 4.1 1 6 30 74.8 9.4 1 9 2 103.8 2.0 1 2 19 127.5 4.5 1 4 26 251.4 6.2 1 6 31 60.5 13.7 1 9 3 572.2 9.0 1 2 20 242.2 4.5 1 4 27 245.9 4.2 1 6 32 91.4 9.1 1 9 4 316.1 4.3 1 2 21 221.8 6.4 1 4 28 144.5 4.8 1 6 33 232.0 4.8 1 9 5 83.7 2.0 1 2 22 269.9 4.9 1 4 29 44.4 12.6 1 7 0 212.9 4.8 1 9 6 372.0 5.0 1 2 23 55.0 14.2 1 4 30 126.4 7.2 1 7 1 160.1 3.0 1 9 7 432.7 5.7 12 24 180.7 4.0 1 4 32 92.4 9.1 17 3 84.9 1.8 19 8 560.3 7.3 1 2 25 144.4 3.9 1 4 33 126.5 6.0 1 7 4 97.2 1.9 1 9 9 415.4 6.0 1 2 26 317.1 4.7 1 4 34 80.6 13.1 1 7 5 315.8 4.3 1 9 10 602.8 8.9 12 27 72.0 7.3 1 5 0 137.6 5.2 1 7 6 168.5 2.8 1 9 11 430.6 5.7 1 2 28 198.7 4.6 1 5 1 225.4 5.6 1 7 7 103.7 2.1 1 9 12 616.1 8.3 1 2 29 158.9 4.1 1 5 3 390.2 6.9 1 7 8 362.5 5.0 1 9 13 113.1 4.1 1 2 30 23.8 12.0 1 5 4 737.6 18.9 1 7 9 136.0 2.6 1 9 14 454.7 7.3 1 2 31 123.3 6.4 1 5 5 425.1 6.6 1 7 10 537.5 7.2 1 9 15 199.7 4.1 12 32 92.0 8.7 1 5 6 257.4 4.3 1 7 11 407.2 6.5 1 9 16 113.3 5.4 1 2 33 101.7 6.9 1 5 7 453.7 6.5 1 7 12 126.3 3.6 1 9 17 442.9 6.2 1 2 34 155.2 6.4 1 5 8 333.4 4.5 1 7 13 306.8 4.3 1 9 18 394.5 5.9 1 3 2 72.5 3.7 1 5 9 374.3 5.3 1 7 14 921.2 12.8 1 9 19 110.8 5.1 1 3 3 231.8 5.8 1 5 10 298.2 4.2 1 7 15 463.0 6.2 1 9 20 386.6 5.6 WO 99/10379 PCT/GB98/02542 -109 1 9 21 233.8 4.3 1 11 28 206.4 4.7 1 14 2 304.6 4.3 1 16 11 667.1 8.8 1 9 22 81.4 6.4 1 11 29 252.3 4.8 1 14 3 205.6 2.5 1 16 12 198.9 4.1 1 9 23 90.8 5.2 1 11 30 177.9 4.7 1 14 4 174.7 2.5 1 16 13 433.6 5.8 1 9 24 69.5 6.9 1 11 31 139.8 6.9 1 14 5 374.2 4.7 1 16 14 270.6 4.8 1 9 25 73.7 6.3 1 11 32 37.9 13.3 1 14 6 394.4 5.6 1 16 15 321.0 6.4 1 9 26 209.0 5.5 1 11 33 130.4 6.6 I 14 7 267.2 3.3 1 16 16 288.2 4.8 1 9 27 285.4 4.7 1 12 0 155.0 5.5 1 14 8 301.0 4.3 1 16 17 47.4 10.6 1 9 28 170.1 5.3 1 12 1 222.3 2.8 1 14 9 403.5 5.9 1 16 18 103.3 5.4 1 9 29 153.3 14.7 1 12 2 579.6 7.1 1 14 10 69.1 4.5 1 16 19 340.5 5.5 1 9 30 123.0 7.9 1 12 3 165.6 2.1 1 14 11 313.0 4.4 1 16 20 199.6 3.8 1 9 31 166.9 4.8 1 12 4 613.3 8.6 1 14 12 480.7 7.0 1 16 21 253.4 4.1 1 9 32 130.9 6.3 1 12 5 717.8 9.2 1 14 13 172.0 5.0 1 16 22 274.4 5.2 1 9 33 149.4 5.2 1 12 6 145.7 2.3 1 14 14 214.5 4.2 1 16 23 327.6 4.8 1 10 1 155.4 2.0 1 12 7 602.4 8.0 1 14 15 476.7 7.0 1 16 24 169.6 4.3 1 10 2 142.5 2.2 1 12 8 540.6 8.5 1 14 16 235.1 4.0 1 16 25 272.9 4.5 1 10 3 235.7 3.4 1 12 9 326.2 4.9 1 14 17 244.1 4.4 1 16 26 119.1 4.7 1 10 4 181.8 2.5 1 12 10 476.6 8.6 1 14 18 255.6 4.3 1 16 27 203.8 13.4 1 10 5 353.2 5.1 1 12 11 415.0 5.4 1 14 19 272.8 4.5 1 16 28 104.6 5.3 1 10 6 371.8 6.0 1 12 12 221.5 3.5 1 14 20 158.1 4.4 1 16 29 148.0 5.1 1 10 7 354.6 4.8 1 12 13 179.2 3.4 1 14 21 187.8 3.8 1 16 30 60.4 11.6 1 10 8 535.5 7.6 1 12 14 426.1 6.0 1 14 22 73.7 7.0 1 16 31 233.3 5.0 1 10 9 67.8 3.5 1 12 15 89.7 5.0 1 14 23 203.9 4.1 1 17 2 418.6 9.4 1 10 10 141.4 2.8 1 12 16 474.5 6.5 1 14 24 120.6 4.5 1 17 3 268.1 3.4 1 10 I1 113.9 3.2 1 12 17 449.4 6.5 1 14 25 15.9 7.9 I 17 4 320.7 4.1 1 10 12 850.4 11.8 1 12 18 292.5 4.4 1 14 26 68.1 6.8 1 17 5 933.0 14.9 1 10 13 577.1 9.0 1 12 19 53.5 9.7 1 14 27 359.5 5.3 1 17 6 306.5 4.3 1 10 14 139.2 3.6 1 12 20 225.0 3.9 1 14 28 103.6 6.8 1 17 7 92.2 2.8 1 10 15 778.3 11.9 1 12 21 170.3 4.7 1 14 29 29.5 11.8 1 17 8 419.9 5.8 1 10 16 509.3 8.8 1 12 22 232.8 4.3 1 14 30 173.3 7.2 1 17 9 409.1 5.9 1 10 17 382.0 5.7 1 12 23 70.2 6.0 1 14 31 148.3 6.2 1 17 10 277.4 4.7 1 10 18 394.2 7.2 1 12 24 164.6 4.4 1 14 32 238.9 4.9 1 17 11 275.6 4.0 1 10 19 198.3 4.2 1 12 25 124.0 4.3 1 15 1 474.1 11.6 1 17 12 478.4 7.1 1 10 20 408.9 5.9 1 12 26 26.4 10.9 1 15 2 522.7 6.4 1 17 13 295.8 4.5 1 10 21 337.7 5.0 1 12 27 78.9 7.7 1 15 3 580.5 7.6 1 17 14 306.0 4.3 1 10 22 175.1 4.1 1 12 28 134.1 22.2 1 15 4 580.1 7.5 1 17 15 222.9 4.3 1 10 23 150.4 3.9 1 12 29 243.5 4.4 1 15 5 141.5 2.1 1 17 16 348.6 6.2 1 10 24 20.7 10.1 1 12 30 89.1 7.7 1 15 6 221.8 3.0 1 17 17 279.4 4.4 1 10 25 244.5 4.4 1 12 31 377.6 5.5 1 15 7 268.3 3.4 1 17 18 178.5 4.3 1 10 26 212.5 4.5 1 12 32 76.9 9.1 1 15 8 361.1 4.8 1 17 19 85.4 4.6 1 10 27 103.2 6.2 1 13 1 116.1 2.2 1 15 9 569.7 7.9 1 17 20 165.0 3.9 1 10 28 52.8 11.5 1 13 2 580.5 8.2 1 15 10 417.9 6.0 1 17 21 237.4 3.9 1 10 29 120.8 9.1 1 13 3 172.3 2.4 1 15 11 230.3 3.7 1 17 22 137.6 4.6 I 10 30 308.3 4.9 1 13 4 234.3 3.2 1 15 12 403.4 5.9 1 17 23 172.3 4.0 1 10 31 157.4 5.4 1 13 5 374.4 5.4 1 15 13 356.9 5.0 1 17 24 159.6 3.8 1 10 32 192.3 4.9 1 13 6 807.9 11.4 1 15 14 334.0 5.3 1 17 25 113.0 4.7 1 10 33 158.2 6.3 1 13 7 678.6 9.8 1 15 15 201.7 3.5 1 17 26 13.6 6.9 1 11 2 202.9 2.7 1 13 8 549.4 7.5 1 15 16 239.1 4.2 1 17 27 100.6 5.9 1 11 3 195.0 2.5 1 13 9 980.2 14.0 1 15 17 337.7 6.1 1 17 28 34.3 12.5 1 11 4 85.0 1.9 1 13 10 504.0 6.5 1 15 18 241.9 4.0 1 17 29 217.0 4.6 1 11 5 220.3 3.5 1 13 11 71.3 3.8 1 15 19 198.3 3.6 1 17 30 121.4 6.0 1 11 6 347.6 4.4 1 13 12 195.0 3.1 1 15 20 78.0 5.8 1 17 31 133.6 6.0 1 1 7 533.8 6.7 1 13 13 250.7 4.3 1 15 21 200.1 3.6 1 18 2 450.3 12.0 1 11 8 235.8 3.3 1 13 14 244.9 4.1 1 15 22 98.0 5.5 1 18 3 301.9 4.3 1 11 9 16.8 7.9 1 13 15 420.9 6.0 1 15 23 435.2 6.9 1 18 4 530.9 7.1 1 11 10 125.4 3.2 1 13 16 162.8 4.0 1 15 24 21.4 9.6 1 18 5 862.6 10.9 1 11 11 287.6 4.6 1 13 17 96.5 6.7 1 15 25 110.6 4.3 1 18 6 661.1 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1 11 26 122.4 4.3 1 13 32 32.1 14.1 1 16 9 483.7 7.6 1 18 21 277.2 4.8 1 11 27 18.9 9.3 1 14 1 356.1 9.1 1 16 10 337.7 4.9 1 18 22 426.7 7.0 WO 99/10379 PCT/GB98/02542 -110 1 18 23 113.9 5.4 1 21 9 593.9 8.2 1 23 27 78.8 7.1 1 26 25 144.1 4.8 1 18 24 172.4 4.8 1 21 10 351.1 4.7 1 23 28 173.2 4.2 1 26 26 69.8 7.3 1 18 25 265.7 4.5 1 21 11 370.2 5.7 1 24 3 258.5 6.1 1 26 27 59.1 9.3 1 18 26 286.1 9.0 1 21 12 209.0 3.3 1 24 4 543.6 10.1 1 27 5 285.7 4.1 1 18 27 212.1 4.4 1 21 13 180.3 3.6 1 24 5 153.8 2.3 1 27 6 137.6 1.9 1 18 28 208.8 4.2 1 21 14 125.7 3.7 1 24 6 66.5 2.5 1 27 7 203.0 2.7 1 18 29 79.1 7.1 1 21 15 176.2 3.9 1 24 7 550.6 7.8 1 27 8 129.6 2.8 1 18 30 211.7 4.3 1 21 16 132.2 3.2 1 24 8 49.1 3.9 1 27 9 97.9 2.2 1 18 31 26.3 12.2 1 21 17 138.8 3.6 1 24 9 297.4 3.9 1 27 10 354.9 4.9 1 19 1 66.1 2.8 1 21 18 184.8 3.3 1 24 10 357.4 7.2 1 27 11 227.3 3.3 1 19 3 282.3 3.4 1 21 19 295.2 4.3 1 24 11 261.6 3.7 1 27 12 234.2 4.3 1 19 4 809.4 11.1 1 21 20 241.4 3.9 1 24 12 154.9 2.7 1 27 13 220.5 3.6 1 19 5 452.2 6.4 1 21 21 172.7 3.2 1 24 13 235.7 3.3 1 27 14 374.9 5.5 1 19 6 835.7 11.5 1 21 22 167.5 3.6 1 24 14 215.3 3.2 1 27 15 209.1 3.3 1 19 7 407.6 5.6 1 21 23 132.7 5.3 1 24 15 172.0 2.9 1 27 16 387.7 5.6 1 19 8 432.7 6.9 1 21 24 103.4 5.2 1 24 16 103.3 3.2 1 27 17 78.2 4.1 1 19 9 555.6 9.0 1 21 25 109.4 5.7 1 24 17 133.1 3.8 1 27 18 311.4 4.6 1 19 10 566.1 8.1 121 26 81.8 6.5 1 24 18 395.6 5.4 127 19 190.0 3.4 1 19 11 351.6 5.2 1 21 27 55.0 8.8 1 24 19 407.9 5.6 1 27 21 245.2 4.1 1 19 12 235.2 3.6 1 21 28 193.8 6.2 1 24 20 95.5 3.9 1 27 22 123.6 4.0 1 19 13 149.9 3.3 1 21 29 180.8 4.4 1 24 21 192.2 3.4 1 27 23 59.8 11.2 1 19 14 318.8 5.6 1 22 3 211.7 5.3 1 24 22 417.8 6.1 1 27 24 63.8 7.9 1 19 15 98.5 5.0 1 22 4 443.6 6.4 1 24 23 211.6 6.4 1 27 25 178.0 3.9 1 19 16 264.2 5.0 1 22 5 206.8 3.5 1 24 24 130.6 4.2 1 27 26 226.0 4.1 1 19 17 420.5 7.3 1 22 6 146.7 2.6 1 24 25 264.5 4.5 1 28 4 205.3 4.6 1 19 18 417.1 7.3 1 22 7 714.7 10.4 1 24 26 53.2 11.5 1 28 5 158.6 4.4 1 19 19 546.7 8.5 1 22 8 358.1 5.0 1 24 27 131.2 4.8 1 28 6 154.7 2.3 1 19 20 116.7 3.6 1 22 9 333.2 4.9 1 24 28 146.4 4.8 1 28 7 212.9 2.8 1 19 21 14.6 7.2 1 22 10 474.9 6.7 1 25 4 126.9 4.1 1 28 8 218.4 2.9 1 19 22 198.3 3.7 1 22 11 271.9 3.8 1 25 5 22.1 7.7 1 28 9 302.1 4.1 1 19 23 58.7 8.4 1 22 12 294.6 4.6 1 25 6 134.3 2.3 1 28 10 284.0 3.8 1 19 24 74.6 5.6 1 22 13 233.5 3.8 1 25 7 432.6 7.2 1 28 11 135.6 2.8 1 19 25 80.6 6.7 1 22 14 138.8 3.2 1 25 8 136.5 2.9 1 28 12 172.2 2.7 1 19 26 71.5 8.4 122 15 131.6 3.0 1 25 9 429.7 6.6 128 13 151.6 2.7 1 19 27 39.9 13.0 1 22 16 89.9 3.8 1 25 10 363.6 6.1 1 28 14 234.3 3.4 1 19 28 106.1 5.4 1 22 17 244.8 3.7 1 25 11 84.4 3.4 1 28 15 297.9 4.7 1 19 29 19.6 9.3 1 22 18 151.0 3.3 1 25 12 434.1 7.5 1 28 16 72.7 4.0 1 19 30 107.0 6.4 1 22 19 72.9 4.7 1 25 13 12.5 6.2 1 28 17 102.8 3.3 1 20 1 17.3 0.6 1 22 20 69.0 5.8 1 25 14 594.5 7.9 1 28 18 113.9 3.2 1 20 3 517.3 7.5 1 22 21 76.0 6.3 1 25 15 222.2 3.5 1 28 19 18.8 9.0 1 20 4 53.7 2.8 1 22 22 173.1 3.5 1 25 16 385.4 5.7 1 28 20 204.8 3.7 1 20 5 482.7 6.0 1 22 23 130.0 4.2 1 25 17 158.5 3.0 1 28 21 75.7 5.8 1 20 6 756.1 10.2 1 22 24 462.6 9.2 1 25 18 267.2 4.3 1 28 22 106.7 4.1 1 20 7 272.6 3.9 1 22 25 170.7 4.1 1 25 19 218.9 4.3 1 28 23 105.6 4.0 1 20 8 250.1 5.3 1 22 26 300.7 4.9 1 25 20 131.2 3.6 1 28 24 128.4 3.7 120 9 353.9 6.2 122 27 35.1 13.7 1 25 21 217.5 3.4 128 25 184.6 5.1 1 20 10 144.2 3.2 1 22 28 121.0 5.3 1 25 22 233.4 9.0 1 29 6 259.1 3.6 1 20 11 243.2 4.2 1 22 29 59.4 8.5 1 25 23 86.7 4.6 1 29 7 270.6 3.5 1 20 12 204.5 3.6 1 23 2 239.0 8.8 1 25 24 130.4 4.1 1 29 8 33.1 4.4 1 20 13 573.1 9.3 1 23 4 268.4 4.1 1 25 25 212.4 4.1 1 29 9 95.2 2.3 1 20 14 488.7 9.2 1 23 5 653.9 8.6 1 25 26 207.7 4.1 1 29 10 269.0 3.9 1 20 15 439.9 6.8 1 23 6 554.0 7.2 1 25 27 228.0 5.3 1 29 11 177.9 2.7 1 20 16 167.7 3.4 1 23 7 170.4 2.7 1 26 5 790.6 14.9 1 29 12 202.1 2.8 1 20 17 454.9 7.3 1 23 8 64.6 3.9 1 26 6 244.8 3.8 1 29 13 98.6 2.9 1 20 18 130.0 3.6 1 23 9 406.3 5.8 1 26 7 367.7 5.4 1 29 14 15.3 7.1 1 20 19 231.2 4.7 1 23 10 86.1 3.4 1 26 8 88.8 2.4 1 29 15 341.3 5.0 1 20 20 100.7 5.4 1 23 11 323.9 4.3 1 26 9 113.6 2.7 1 29 16 294.8 5.1 1 20 21 214.6 3.8 1 23 12 212.8 3.1 1 26 10 254.2 3.8 1 29 17 172.3 3.0 1 20 22 298.9 4.4 1 23 13 236.8 3.4 1 26 11 222.4 3.0 1 29 18 59.3 7.6 1 20 23 94.2 5.5 1 23 14 230.7 3.6 1 26 12 317.2 4.8 1 29 19 92.4 10.9 1 20 24 170.0 4.3 1 23 15 123.8 3.2 1 26 13 404.9 6.6 1 29 20 162.1 3.3 1 20 25 228.8 8.7 1 23 16 301.7 5.0 1 26 14 218.2 3.2 1 29 21 189.3 4.2 1 20 26 171.5 4.2 1 23 17 409.2 5.3 1 26 15 266.6 4.8 1 29 22 349.4 6.0 1 20 27 65.7 10.1 1 23 18 60.4 5.8 1 26 16 237.1 3.6 1 29 23 101.5 4.6 1 20 28 99.1 5.4 1 23 19 263.7 4.0 1 26 17 31.8 7.8 1 29 24 95.4 6.5 1 20 29 170.1 5.7 1 23 20 145.0 3.7 1 26 18 229.5 3.5 1 29 25 180.3 5.6 1 20 30 134.1 4.8 1 23 21 237.2 3.6 1 26 19 164.6 3.7 1 30 5 302.2 7.9 1 21 4 652.4 9.1 1 23 22 117.0 3.8 1 26 20 136.3 3.5 1 30 6 264.8 4.0 1 21 5 301.3 4.0 1 23 23 195.6 4.9 1 26 21 111.5 7.9 1 30 7 281.1 3.7 1 21 6 96.7 3.0 1 23 24 37.3 11.4 1 26 22 86.7 6.1 1 30 8 273.8 4.0 1 21 7 150.1 3.7 1 23 25 116.3 4.7 1 26 23 123.3 4.4 1 30 9 69.8 2.8 1 21 8 438.2 6.0 1 23 26 167.1 4.5 1 26 24 280.8 4.9 1 30 10 155.0 2.4 WO 99/10379 PCT/GB98/02542 -111 I 30 11 169.3 2.8 1 34 14 190.5 3.2 2 0 11 86.7 3.9 2 2 19 115.1 5.4 1 30 12 122.9 3.1 I 34 15 102.3 3.1 2 0 12 367.4 8.9 2 2 20 371.7 5.5 1 30 13 264.7 3.8 I 34 16 268.5 4.3 2 0 13 608.7 13.3 2 2 21 193.0 4.7 1 30 14 90.6 3.4 1 34 17 141.1 3.8 2 0 14 664.7 16.0 2 2 22 185.1 4.4 1 30 15 192.1 3.7 1 34 18 97.6 3.9 2 0 15 414.4 8.3 2 2 23 376.9 6.1 1 30 16 70.0 4.2 1 34 19 130.9 3.3 2 0 16 523.0 11.1 2 2 24 122.9 5.4 1 30 17 22.8 9.5 1 34 20 46.6 10.3 2 0 17 453.3 10.0 2 2 25 275.4 4.4 1 30 18 106.4 6.1 1 35 5 14.9 2.8 2 0 18 204.4 9.0 2 2 26 296.0 4.8 1 30 19 78.0 4.6 1 35 7 99.8 3.6 2 0 19 120.2 7.5 2 2 27 187.3 4.1 1 30 20 123.1 3.8 1 35 8 127.1 2.8 2 0 20 683.4 14.2 2 2 28 115.1 5.4 1 30 21 186.9 3.6 1 35 9 151.8 3.8 2 0 21 248.2 6.7 2 2 29 52.9 15.2 1 30 22 180.7 3.7 1 35 10 281.4 7.5 2 0 23 95.8 15.7 2 2 30 218.4 5.2 1 30 23 53.2 7.2 1 35 11 159.5 3.8 2 0 24 61.8 19.5 2 2 31 179.6 6.3 1 30 24 83.4 5.5 1 35 12 140.0 2.8 2 0 25 355.1 8.8 2 2 32 106.6 8.2 1 31 6 83.3 3.9 1 35 13 144.5 3.0 2 0 26 94.2 10.3 2 2 33 219.2 5.1 1 31 7 249.7 4.1 1 35 14 76.3 3.7 2 0 27 30.7 17.2 2 2 34 102.1 12.6 1 31 8 249.9 3.9 1 35 15 170.4 3.1 2 0 28 15.8 11.2 2 3 1 228.4 6.0 1 31 9 88.0 2.2 1 35 16 88.2 5.1 2 0 29 20.5 13.9 2 3 2 89.9 1.9 1 31 10 239.9 3.5 1 35 17 136.1 3.9 2 0 30 209.0 8.6 2 3 3 352.2 8.0 1 31 11 506.8 6.4 1 35 18 16.4 7.7 2 0 31 180.6 7.5 2 3 4 562.7 13.3 1 31 12 212.7 3.2 1 35 19 173.0 3.4 2 0 32 222.1 7.2 2 3 5 497.2 9.6 1 31 13 124.4 2.5 1 36 8 120.5 5.4 2 0 33 259.7 7.9 2 3 6 579.0 11.2 1 31 14 137.0 2.7 1 36 9 36.2 5.4 2 0 34 16.1 12.0 2 3 7 224.9 3.9 1 31 15 173.8 3.0 1 36 10 115.3 2.6 2 1 3 55.2 2.5 2 3 8 361.8 5.1 1 31 16 97.0 4.4 1 36 11 179.6 3.3 2 1 4 325.8 6.0 2 3 9 742.8 11.3 1 31 17 189.4 3.6 1 36 12 97.7 2.7 2 1 5 241.3 4.3 2 3 10 250.5 3.6 1 31 18 181.0 3.3 1 36 13 81.4 3.4 2 1 6 189.6 3.3 2 3 11 324.3 4.4 1 31 19 22.1 9.4 1 36 14 116.8 3.6 2 1 7 224.1 3.5 2 3 12 319.8 4.2 1 31 20 14.0 7.0 1 36 15 264.0 4.2 2 1 8 144.4 2.7 2 3 13 54.0 5.2 1 31 21 127.0 3.9 1 36 16 122.0 3.1 2 1 9 413.8 5.5 2 3 14 201.1 3.4 1 31 22 80.4 5.7 1 36 17 101.7 3.4 2 1 10 139.6 2.8 2 3 15 662.4 9.7 1 31 23 80.9 6.6 1 36 18 52.0 6.6 2 1 11 446.7 6.4 2 3 16 249.6 3.9 1 32 6 99.9 3.5 1 37 8 203.8 8.7 2 1 12 234.3 3.8 2 3 17 263.1 4.1 1 32 7 211.3 3.9 1 37 9 94.8 1.9 2 1 13 295.4 4.3 2 3 18 226.4 4.6 1 32 8 71.2 2.2 1 37 10 127.4 3.2 2 1 14 677.0 8.5 2 3 19 186.8 4.6 1 32 9 76.0 2.9 1 37 11 118.2 2.6 2 1 15 273.6 4.2 2 3 20 223.1 4.5 1 32 10 138.4 2.5 1 37 12 209.0 4.2 2 1 16 274.7 4.4 2 3 21 154.3 5.2 1 32 11 108.8 2.9 1 37 13 158.1 3.0 2 1 17 278.8 4.7 2 3 22 111.1 5.1 1 32 12 205.3 3.3 1 37 14 135.6 3.1 2 1 18 279.5 5.6 2 3 23 121.8 4.7 1 32 13 150.1 2.8 1 37 15 140.7 3.0 2 1 19 308.8 4.6 2 3 24 16.4 8.3 1 32 14 95.9 3.2 1 37 16 38.9 8.7 2 1 20 113.8 5.6 2 3 25 167.7 4.3 1 32 15 354.7 6.3 1 37 17 146.0 3.6 2 1 21 286.4 4.5 2 3 26 217.8 4.1 1 32 16 97.1 3.6 1 38 6 17.7 2.5 2 1 22 137.5 4.4 2 3 27 120.3 4.9 1 32 17 105.1 3.4 1 38 8 172.5 5.1 2 1 23 79.4 7.9 2 3 28 65.5 9.5 1 32 18 324.7 5.3 1 38 9 295.6 5.3 2 1 24 322.9 4.6 2 3 29 107.5 8.4 1 32 19 139.6 3.7 1 38 10 294.2 4.9 2 1 25 275.7 5.1 2 3 30 226.1 5.3 1 32 20 82.8 3.9 1 38 11 85.8 2.5 2 1 26 156.1 4.9 2 3 31 133.5 7.2 1 32 21 63.3 4.7 1 38 12 73.1 4.1 2 1 27 146.5 4.6 2 3 32 169.3 6.6 1 32 22 40.6 10.9 1 38 13 123.6 3.0 2 1 28 83.0 6.9 2 3 33 73.8 13.5 1 33 6 164.6 4.5 1 38 14 139.7 2.8 2 1 29 153.8 4.8 2 4 0 276.1 5.8 1 33 7 100.9 2.1 1 38 15 94.1 3.8 2 1 30 113.2 11.0 2 4 1 363.5 11.2 1 33 8 150.0 2.3 1 39 8 191.5 5.9 2 1 31 103.6 8.7 2 4 2 320.8 7.9 1 33 9 40.7 4.4 1 39 9 205.5 7.2 2 1 32 305.7 6.0 2 4 3 206.9 4.0 1 33 10 250.1 3.9 1 39 10 192.3 3.3 2 1 33 147.1 5.6 2 4 4 820.4 21.8 1 33 11 222.6 3.5 1 39 11 109.1 2.3 2 1 34 74.3 14.7 2 4 5 212.0 4.1 1 33 12 255.9 4.0 1 39 12 115.8 2.7 2 2 2 259.0 5.5 2 4 6 46.2 3.2 1 33 13 158.1 3.1 1 39 13 130.4 2.7 2 2 3 163.9 3.9 2 4 7 123.5 2.4 1 33 14 157.6 9.1 1 39 14 220.0 5.5 2 2 4 471.2 9.8 2 4 8 368.7 5.4 1 33 15 324.6 4.9 1 40 8 17.8 7.0 2 2 5 287.7 5.9 2 4 9 276.8 4.0 1 33 16 216.7 3.5 1 40 9 172.3 3.8 2 2 6 103.2 2.2 2 4 10 317.6 4.5 1 33 17 212.8 3.6 1 40 10 127.2 2.3 2 2 7 317.4 4.6 2 4 11 83.3 3.6 1 33 18 96.1 4.5 1 40 11 110.5 2.8 2 2 8 317.1 4.5 2 4 12 336.6 5.0 1 33 19 149.2 4.1 1 40 12 123.6 3.8 2 2 9 383.7 5.8 2 4 13 300.2 4.5 1 33 20 189.2 3.5 1 41 9 61.8 4.8 2 2 10 201.0 3.3 2 4 14 256.1 3.9 1 33 21 16.7 8.1 2 0 3 343.8 15.4 2 2 11 327.9 4.7 2 4 15 308.4 4.8 1 34 7 54.5 2.7 2 0 4 229.6 6.6 2 2 12 175.8 3.1 2 4 16 147.7 4.3 1 34 8 213.0 3.4 2 0 5 154.2 5.2 2 2 13 469.1 6.3 2 4 17 98.7 6.5 1 34 9 174.9 2.8 2 0 6 319.3 7.6 2 2 14 492.6 6.7 2 4 18 630.4 8.5 1 34 10 183.4 2.8 2 0 7 362.2 8.8 2 2 15 232.7 3.8 2 4 19 1010.1 14.8 1 34 11 98.7 3.1 2 0 8 514.5 11.7 2 2 16 52.1 6.6 2 4 20 227.2 4.4 1 34 12 245.2 6.1 2 0 9 34.3 12.1 2 2 17 356.4 6.4 2 4 21 76.9 6.6 1 34 13 119.0 3.2 2 0 10 366.1 8.0 2 2 18 440.3 6.4 2 4 22 163.8 4.4 WO 99/10379 PCT/GB98/02542 -112 2 4 23 132.1 4.2 2 6 28 86.7 12.0 2 8 32 255.5 4.9 2 11 5 355.1 4.7 2 4 24 58.8 10.6 2 6 29 208.2 13.3 2 8 33 128.2 6.5 2 11 6 284.5 5.1 2 4 25 59.4 12.6 2 6 30 85.3 9.3 2 9 0 404.2 7.9 2 11 7 351.7 5.3 2 4 26 189.2 4.4 2 6 31 307.5 5.8 2 9 1 531.7 9.7 2 11 8 240.9 3.4 2 4 27 26.4 11.3 2 6 32 218.8 7.1 2 9 2 249.8 3.0 2 11 9 147.7 3.1 2 4 28 120.4 5.3 2 6 33 196.9 5.3 2 9 3 302.2 4.2 2 11 10 180.9 3.2 2 4 29 133.1 7.3 2 7 0 610.6 18.5 2 9 4 77.5 2.3 2 11 11 443.5 6.3 2 4 30 202.9 6.0 2 7 1 428.4 6.7 2 9 5 277.2 4.7 2 11 12 282.2 4.2 2 4 31 162.8 7.8 2 7 2 652.5 14.8 2 9 6 222.5 3.9 2 11 13 843.9 12.3 2 4 32 176.8 5.8 2 7 3 291.0 4.6 2 9 7 141.0 3.1 2 11 14 280.8 4.5 2 4 33 173.4 5.8 2 7 4 185.1 2.9 2 9 8 339.3 4.7 2 11 15 388.1 5.7 2 5 0 307.4 5.1 2 7 5 217.1 3.0 2 9 9 537.1 8.1 2 11 16 55.7 13.7 2 5 1 553.9 9.1 2 7 6 470.1 6.2 2 9 10 177.6 2.8 2 11 17 414.0 5.8 2 5 2 95.0 2.1 2 7 7 285.1 4.0 2 9 11 627.2 9.3 2 11 18 33.4 13.3 2 5 3 320.1 7.9 2 7 8 566.6 8.2 2 9 12 237.6 3.7 2 11 19 544.4 7.8 2 5 4 603.9 9.8 2 7 9 348.9 4.7 2 9 13 598.9 8.9 2 11 20 116.4 4.9 2 5 5 153.0 2.7 2 7 10 155.1 2.8 2 9 14 144.8 3.0 2 11 21 28.7 11.6 2 5 6 570.3 9.7 2 7 11 441.1 6.6 2 9 15 314.7 5.5 2 11 22 272.3 4.5 2 5 7 325.8 4.4 2 7 12 569.2 8.3 2 9 16 327.8 5.3 2 11 23 258.6 4.1 2 5 8 457.8 6.2 2 7 13 366.5 5.1 2 9 17 252.2 4.5 2 11 24 160.4 4.8 2 5 9 187.1 3.1 2 7 14 647.6 9.3 2 9 18 327.8 5.1 2 11 25 191.8 4.6 2 5 10 321.5 5.7 2 7 15 462.3 6.6 2 9 19 185.1 4.0 2 11 26 194.9 4.8 2 5 11 189.7 3.0 2 7 16 84.3 13.3 2 9 20 348.8 5.5 2 11 27 106.6 8.2 2 5 12 279.4 4.4 2 7 17 332.2 6.0 2 9 21 148.3 4.7 2 11 28 247.3 18.6 2 5 13 80.5 5.0 2 7 18 457.3 7.4 2 9 22 146.8 5.4 2 11 29 52.8 13.9 2 5 14 181.0 4.0 2 7 19 254.3 4.4 2 9 23 291.4 4.7 2 11 30 210.8 5.5 2 5 15 832.8 12.1 2 7 20 265.0 4.5 2 9 24 90.2 5.8 2 11 31 119.1 6.5 2 5 16 560.4 9.6 2 7 21 34.2 13.6 2 9 25 243.1 4.8 2 11 32 113.3 5.9 2 5 17 361.8 5.4 2 7 22 95.8 6.2 2 9 26 265.5 4.9 2 12 0 99.2 2.4 2 5 18 136.5 5.2 2 7 23 71.7 9.3 2 9 27 112.7 6.1 2 12 1 109.9 1.6 2 5 19 314.5 5.0 2 7 24 447.0 5.7 2 9 28 99.7 7.6 2 12 2 383.5 5.0 2 5 20 283.7 5.5 2 7 25 103.5 6.9 2 9 30 163.0 6.0 2 12 3 520.6 7.3 2 5 21 216.1 4.9 2 7 26 21.0 9.8 2 9 31 393.8 8.6 2 12 4 422.2 6.0 2 5 22 133.7 5.1 2 7 27 30.6 12.5 2 9 32 182.7 4.9 2 12 5 206.4 2.9 2 5 23 175.1 5.2 2 7 28 87.7 8.3 2 9 33 174.7 5.5 2 12 6 591.9 8.0 2 5 24 144.4 4.6 2 7 29 412.2 9.6 2 10 0 301.4 5.6 2 12 7 410.3 5.2 2 5 25 135.7 5.4 2 7 30 284.0 5.0 2 10 1 458.7 6.6 2 12 8 212.6 3.1 2 5 26 97.5 8.3 2 7 31 73.0 10.8 2 10 2 118.6 1.9 2 12 9 297.1 4.7 2 5 27 113.8 5.5 2 7 32 167.3 7.4 2 10 3 331.8 4.1 2 12 10 606.9 8.0 2 5 28 31.0 12.7 2 7 33 105.1 8.8 2 10 4 360.0 4.7 2 12 11 401.7 5.7 2 5 29 187.0 7.8 2 8 0 639.4 14.0 2 10 5 25.7 5.2 2 12 12 287.8 4.2 2 5 30 135.0 6.7 2 8 1 194.4 3.2 2 10 6 411.6 5.8 2 12 13 424.8 5.2 2 5 31 81.3 11.3 2 8 2 455.0 7.7 2 10 7 208.3 2.9 2 12 14 562.5 8.3 2 5 32 164.5 5.9 2 8 3 175.4 3.3 2 10 8 128.6 2.3 2 12 15 396.1 6.1 2 5 33 204.8 5.2 2 8 4 249.5 3.8 2 10 9 102.0 2.9 2 12 16 154.8 3.6 2 6 0 189.3 4.2 2 8 5 198.2 3.2 2 10 10 219.6 3.4 2 12 17 424.1 7.1 2 6 2 633.1 10.6 2 8 6 264.3 3.4 2 10 11 722.1 9.6 2 12 18 585.2 8.8 2 6 3 43.7 2.4 2 8 7 434.2 6.2 2 10 12 169.7 3.4 2 12 19 88.9 7.9 2 6 4 909.9 16.7 2 8 8 150.7 2.4 2 10 13 258.5 4.0 2 12 20 31.3 11.5 2 6 5 281.7 4.9 2 8 9 597.9 8.3 2 10 14 515.2 6.6 2 12 21 284.4 5.8 2 6 6 246.0 3.9 2 8 10 515.2 7.7 2 10 15 412.5 6.0 2 12 22 118.5 7.2 2 6 7 96.6 3.0 2 8 11 524.0 7.0 2 10 16 281.8 6.2 2 12 23 310.7 5.0 2 6 8 57.1 3.3 2 8 12 336.9 5.0 2 10 17 98.9 5.8 2 12 24 237.4 4.3 2 6 9 246.2 4.3 2 8 13 317.6 4.0 2 10 18 243.8 4.3 2 12 25 64.5 7.7 2 6 10 190.1 3.6 2 8 14 514.6 7.4 2 10 19 219.7 4.1 2 12 26 146.0 4.9 2 6 11 208.8 3.2 2 8 15 363.0 5.2 2 10 20 192.6 4.8 2 12 27 45.3 14.5 2 6 12 239.8 3.6 2 8 16 344.5 5.1 2 10 21 151.0 4.7 2 12 28 325.3 9.0 2 6 13 449.3 6.5 2 8 17 227.1 4.6 2 10 22 225.0 4.4 2 12 29 77.5 12.6 2 6 14 1047.3 14.3 2 8 18 234.0 4.2 2 10 23 146.8 4.6 2 12 30 106.4 7.2 2 6 15 401.9 6.6 2 8 19 368.9 5.9 2 10 24 282.6 4.6 2 12 31 123.3 6.8 2 6 16 202.3 6.2 2 8 20 108.2 4.9 2 10 25 149.9 4.5 2 12 32 227.5 7.6 2 6 17 731.5 10.9 2 8 21 192.7 4.6 2 10 26 259.9 4.3 2 13 0 367.1 7.1 2 6 18 331.2 4.8 2 8 22 151.3 7.3 2 10 27 236.3 4.6 2 13 1 42.7 2.7 2 6 19 134.3 5.8 2 8 23 98.4 5.8 2 10 29 192.8 5.0 2 13 2 146.7 2.6 2 6 20 250.2 4.8 2 8 24 128.6 6.0 2 10 30 132.2 6.3 2 13 3 86.6 1.9 2 6 21 168.0 4.1 2 8 25 150.7 5.3 2 10 31 238.8 5.1 2 13 4 136.6 1.9 2 6 22 100.0 7.7 2 8 26 57.5 9.1 2 10 32 280.1 4.9 2 13 5 492.5 6.9 2 6 23 83.8 8.3 2 8 27 179.6 4.3 2 11 0 802.8 18.8 2 13 6 288.8 3.9 2 6 24 151.8 4.9 2 8 28 224.2 4.4 2 11 1 278.7 4.3 2 13 7 652.8 8.1 2 6 25 208.8 4.4 2 8 29 225.2 19.0 2 11 2 651.6 8.4 2 13 8 454.1 6.0 2 6 26 154.0 4.6 2 8 30 163.2 7.0 2 11 3 211.5 3.1 2 13 9 130.8 2.5 2 6 27 63.3 10.0 2 8 31 108.5 7.5 2 11 4 149.8 2.1 2 13 10 446.3 6.1 WO 99/10379 PCT/GB98/02542 -113 2 13 11 303.1 4.3 2 15 18 232.4 4.1 2 17 28 57.0 15.5 2 20 8 537.8 7.5 2 13 12 765.0 10.8 2 15 19 63.7 7.2 2 17 29 255.6 4.7 2 20 9 378.0 5.3 2 13 13 435.7 6.8 2 15 20 361.1 5.6 2 17 30 26.8 12.3 2 20 10 127.5 2.9 2 13 14 139.7 3.8 2 15 21 318.0 5.0 2 17 31 200.4 4.5 2 20 11 294.2 4.2 2 13 15 405.4 6.8 2 15 22 113.8 4.4 2 18 0 767.9 21.3 2 20 12 173.9 3.5 2 13 16 158.5 4.8 2 15 23 305.8 5.7 2 18 1 107.5 2.5 2 20 13 189.7 4.7 2 13 17 178.1 3.9 2 15 24 109.7 4.8 2 18 2 555.2 7.3 2 20 14 353.4 4.9 2 13 18 155.0 3.8 2 15 26 23.5 10.7 2 18 3 620.2 8.0 2 20 15 467.2 7.8 2 13 19 166.4 4.2 2 15 27 349.9 8.4 2 18 4 516.0 6.9 2 20 16 443.6 6.9 2 13 20 93.0 10.3 2 15 28 333.7 6.8 2 18 5 529.1 7.4 2 20 17 218.3 3.6 2 13 21 140.2 5.3 2 15 29 43.0 15.0 2 18 6 238.5 3.4 2 20 18 217.5 3.7 2 13 22 69.3 7.7 2 15 30 108.4 6.9 2 18 7 428.3 5.7 2 20 19 192.2 3.7 2 13 23 214.5 4.0 2 15 31 114.2 6.5 2 18 8 632.6 9.2 2 20 20 175.8 3.6 2 13 24 126.7 4.6 2 16 0 75.5 3.5 2 18 9 630.7 8.5 2 20 21 224.6 4.3 2 13 25 200.5 4.5 2 16 1 340.9 6.0 2 18 10 17.2 8.1 2 20 22 111.6 5.2 2 13 26 89.8 7.3 2 16 2 305.5 3.8 2 18 11 51.6 10.2 2 20 23 181.2 3.9 2 13 27 17.6 8.9 2 16 3 247.7 3.3 2 18 12 429.7 6.3 2 20 24 91.0 6.3 2 13 29 159.7 7.2 2 16 4 195.5 2.4 2 18 13 371.0 5.2 2 20 25 326.7 10.9 2 13 30 131.4 5.9 2 16 5 388.3 5.2 2 18 14 485.6 7.3 2 20 26 104.4 6.0 2 13 31 193.3 4.8 2 16 6 25.9 8.0 2 18 15 328.3 4.8 2 20 27 146.3 5.1 2 13 32 180.6 5.7 2 16 7 137.1 2.8 2 18 16 144.3 3.7 2 20 28 155.2 6.1 2 14 0 358.5 6.9 2 16 8 600.3 7.6 2 18 17 186.4 3.7 2 20 29 84.5 7.8 2 14 1 234.3 3.5 2 16 9 414.6 5.5 2 18 18 225.7 3.8 2 20 30 21.5 10.7 2 14 2 158.2 2.2 2 16 10 487.0 6.3 2 18 19 457.9 7.0 2 21 0 643.8 15.6 2 14 3 256.8 3.1 2 16 11 329.0 5.2 2 18 20 397.6 6.0 2 21 1 431.8 10.2 2 14 4 226.9 3.2 2 16 12 344.5 5.5 2 18 21 259.2 4.1 2 21 2 475.3 8.4 2 14 5 150.1 2.4 2 16 13 515.4 9.0 2 18 22 139.2 5.3 2 21 3 865.9 13.5 2 14 6 598.8 7.9 2 16 14 448.3 6.5 2 18 23 148.1 4.3 2 21 4 244.5 4.0 2 14 7 412.9 6.1 2 16 15 366.8 6.4 2 18 24 158.1 4.1 2 21 5 652.0 8.1 2 14 8 191.9 3.7 2 16 16 245.4 4.0 2 18 25 57.3 11.0 2 21 6 222.5 3.9 2 14 9 767.1 10.5 2 16 17 73.2 5.4 2 18 26 216.7 9.1 2 21 7 102.4 4.2 2 14 10 131.4 2.8 2 16 18 196.2 4.1 2 18 27 95.3 7.0 2 21 8 310.7 4.7 2 14 11 530.5 7.3 2 16 19 134.6 4.5 2 18 28 141.2 4.4 2 21 9 59.3 5.9 2 14 12 399.3 5.8 2 16 20 70.5 7.8 2 18 29 136.3 5.6 2 21 10 206.0 3.7 2 14 13 277.4 4.4 2 16 21 155.5 4.5 2 18 30 64.2 9.5 2 21 11 321.0 4.4 2 14 14 654.4 7.9 2 16 22 221.9 4.0 2 19 1 413.1 7.0 2 21 12 460.1 6.6 2 14 15 202.0 3.7 2 16 23 260.2 4.5 2 19 2 355.4 4.7 2 21 13 235.7 3.9 2 14 16 137.0 5.0 2 16 24 141.5 7.3 2 19 3 277.9 3.5 2 21 14 377.4 5.8 2 14 17 160.2 5.0 2 16 25 265.2 5.3 2 19 4 435.2 5.8 2 21 15 213.9 4.1 2 14 18 236.0 3.9 2 16 26 75.7 8.2 2 19 5 613.0 7.8 2 21 16 246.8 4.1 2 14 19 152.2 5.2 2 16 28 154.3 5.4 2 19 6 301.5 4.3 2 21 17 357.7 5.1 2 14 20 137.4 3.8 2 16 29 190.8 4.8 2 19 7 248.0 4.0 2 21 18 118.6 4.0 2 14 21 33.5 13.3 2 16 30 103.0 7.4 2 19 8 329.7 5.3 2 21 19 52.5 7.8 2 14 22 69.7 7.8 2 16 31 145.0 9.4 2 19 9 774.7 9.2 2 21 20 83.7 5.6 2 14 23 50.6 10.5 2 17 0 548.7 15.7 2 19 10 748.5 10.2 2 21 21 135.6 3.6 2 14 24 154.6 6.6 2 17 1 137.7 2.4 2 19 11 695.7 8.6 2 21 22 191.5 4.4 2 14 25 159.6 5.5 2 17 2 500.7 6.2 2 19 12 472.3 7.0 2 21 23 259.5 4.3 2 14 26 110.9 6.4 2 17 3 742.2 9.7 2 19 13 337.5 5.8 2 21 24 21.1 10.6 2 14 27 245.4 6.2 2 17 4 589.3 7.7 2 19 14 374.3 5.7 2 21 25 123.7 5.3 2 14 28 160.8 5.5 2 17 5 714.7 9.6 2 19 15 203.0 3.8 2 21 26 85.3 7.1 2 14 29 220.0 4.4 2 17 6 1001.3 13.9 2 19 16 129.8 3.8 2 21 27 108.5 6.8 2 14 30 229.6 5.3 2 17 7 432.3 5.6 2 19 17 212.5 3.8 2 21 28 184.9 4.4 2 14 31 50.6 16.2 2 17 8 99.9 2.7 2 19 18 217.1 3.8 2 21 29 123.3 6.6 2 14 32 210.4 5.0 2 17 9 220.6 3.4 2 19 19 295.6 4.5 2 22 0 301.9 8.2 2 15 0 308.1 6.1 2 17 10 335.1 4.9 2 19 20 283.8 4.2 2 22 1 377.9 10.2 2 15 1 264.4 3.9 2 17 11 611.8 7.8 2 19 21 245.9 4.2 2 22 2 508.8 14.1 2 15 2 502.5 6.7 2 17 12 131.5 3.9 2 19 22 108.7 4.2 2 22 3 122.3 4.0 2 15 3 178.6 2.4 2 17 13 259.0 4.0 2 19 23 47.7 10.4 2 22 4 443.6 5.7 2 15 4 534.6 7.2 2 17 14 534.8 9.2 2 19 24 91.9 6.3 2 22 5 591.8 8.2 2 15 5 365.0 4.9 2 17 15 212.4 4.2 2 19 25 16.6 8.4 2 22 6 30.0 8.9 2 15 6 414.3 5.8 2 17 16 184.5 4.4 2 19 26 25.4 11.6 2 22 7 184.2 2.7 2 15 7 524.2 6.9 2 17 17 304.0 4.2 2 19 27 108.6 5.1 2 22 8 82.9 5.0 2 15 8 507.0 7.6 2 17 18 103.1 4.1 2 19 28 68.0 11.0 2 22 9 259.4 4.0 2 15 9 180.3 2.6 2 17 19 165.6 4.2 2 19 29 61.9 9.2 2 22 10 188.3 5.5 2 15 10 201.0 3.3 2 17 20 256.8 4.3 2 19 30 155.5 6.9 2 22 11 460.7 5.9 2 15 11 434.1 6.3 2 17 21 130.7 4.3 2 20 0 757.7 20.1 2 22 12 14.3 7.1 2 15 12 226.7 4.7 2 17 22 113.6 5.1 2 20 2 92.1 2.3 2 22 13 292.4 5.0 2 15 13 232.6 4.3 2 17 23 219.6 4.1 2 20 3 489.0 5.9 2 22 14 78.8 5.7 2 15 14 262.3 4.5 2 17 24 40.4 14.6 2 20 4 782.6 11.2 2 22 15 423.7 6.1 2 15 15 392.5 5.5 2 17 25 175.1 4.8 2 20 5 150.8 4.3 2 22 16 172.8 3.6 2 15 16 185.3 3.9 2 17 26 279.6 9.8 2 20 6 822.5 10.4 2 22 17 210.2 3.7 2 15 17 387.7 5.4 2 17 27 171.6 4.8 2 20 7 562.6 7.2 2 22 18 173.3 4.2 WO 99/10379 PCT/GB98/02542 -114 2 22 19 210.3 3.6 2 25 11 315.8 7.1 2 28 11 229.9 3.7 2 31 21 52.3 8.6 2 22 20 104.0 4.0 2 25 12 80.4 3.9 2 28 12 209.3 3.4 2 31 22 115.0 3.7 2 22 21 140.6 4.5 2 25 13 94.6 3.0 2 28 13 201.8 3.3 2 31 23 31.8 11.9 2 22 22 72.4 7.2 2 25 14 118.6 3.8 2 28 14 232.3 3.4 2 32 5 417.6 9.6 2 22 23 22.7 10.2 2 25 15 469.7 6.6 2 28 15 247.0 4.5 2 32 6 177.3 2.8 2 22 24 229.0 7.1 2 25 16 363.6 5.4 2 28 16 211.1 3.3 2 32 7 245.9 3.8 2 22 25 195.3 4.2 2 25 17 282.9 4.3 2 28 17 100.8 3.5 2 32 8 87.7 2.4 2 22 26 147.8 4.5 2 25 18 158.4 3.3 2 28 18 159.2 3.2 2 32 9 234.3 3.9 2 22 27 90.9 5.9 2 25 19 198.8 3.5 2 28 19 109.6 7.4 2 32 10 180.9 3.2 2 22 28 89.6 7.4 2 25 20 286.0 4.6 2 28 20 151.8 3.8 2 32 11 220.2 3.3 2 22 29 108.2 6.1 2 25 21 141.7 3.5 2 28 21 97.1 4.4 2 32 12 30.3 7.3 2 23 1 729.5 17.9 2 25 22 174.5 17.4 2 28 22 73.4 8.5 2 32 13 255.1 4.6 2 23 3 672.2 10.0 2 25 23 148.9 4.2 2 28 23 222.5 3.9 2 32 14 114.4 3.5 2 23 4 470.0 6.4 2 25 24 88.8 6.9 2 28 24 47.9 14.5 2 32 15 381.0 6.9 2 23 5 343.7 4.8 2 25 25 160.8 4.1 2 28 25 232.6 4.2 2 32 16 139.0 3.8 2 23 6 390.8 5.6 2 25 26 170.7 4.3 2 29 4 236.5 8.7 2 32 17 266.6 3.8 2 23 7 474.1 7.2 2 25 27 217.0 4.5 2 29 5 298.2 8.7 2 32 18 249.5 4.3 2 23 8 173.8 3.1 2 26 4 40.0 3.9 2 29 6 305.9 4.6 2 32 19 132.4 3.4 2 23 9 176.5 3.1 2 26 5 67.1 3.1 2 29 7 326.6 4.7 2 32 20 160.4 3.4 2 23 10 29.3 8.6 2 26 6 238.1 3.2 2 29 8 113.2 2.2 2 32 21 79.8 6.6 2 23 11 132.0 3.2 2 26 7 310.7 4.3 2 29 9 312.9 4.3 2 32 22 52.3 7.7 2 23 12 173.0 3.1 2 26 8 331.1 5.2 2 29 10 253.4 3.5 2 33 6 236.7 6.9 2 23 13 343.3 5.1 2 26 9 402.2 5.5 2 29 11 54.8 4.1 2 33 7 317.2 4.4 2 23 14 115.2 3.8 2 26 10 183.9 3.3 2 29 12 211.7 3.1 2 33 8 105.7 2.5 2 23 15 230.3 3.3 2 26 11 131.8 3.1 2 29 13 348.0 5.1 2 33 9 72.7 2.7 2 23 16 344.3 5.6 2 26 12 240.5 3.6 2 29 14 81.8 4.4 2 33 10 108.6 2.2 2 23 17 71.3 5.9 2 26 13 243.7 4.0 2 29 15 106.6 3.0 2 33 11 182.0 2.9 2 23 18 116.0 3.5 2 26 14 201.2 3.2 2 29 16 280.3 4.8 2 33 12 397.0 7.1 2 23 19 122.7 4.5 2 26 15 81.0 5.4 2 29 17 230.9 3.5 2 33 13 252.5 7.6 2 23 20 27.2 10.0 2 26 16 142.3 3.7 2 29 18 241.9 5.5 2 33 14 17.6 8.2 2 23 21 59.7 6.4 2 26 17 13.0 6.6 2 29 19 53.4 6.2 2 33 15 45.7 5.6 2 23 22 22.9 10.2 2 26 18 94.8 4.1 2 29 20 160.2 3.8 2 33 16 14.8 7.3 2 23 23 294.9 9.2 2 26 19 296.5 4.2 2 29 21 162.9 3.4 2 33 17 63.2 6.4 2 23 24 75.2 9.5 2 26 20 52.9 7.9 2 29 22 72.2 6.1 2 33 18 38.6 10.2 2 23 25 250.9 4.7 2 26 21 308.1 13.6 2 29 23 120.8 5.5 2 33 19 142.5 3.3 2 23 26 158.7 5.4 2 26 22 182.9 3.7 2 29 24 68.3 6.0 2 33 20 68.7 5.4 2 23 27 79.8 9.8 2 26 23 53.5 8.7 2 30 5 262.4 5.2 2 33 21 145.3 3.7 2 23 28 157.0 4.3 2 26 24 78.8 6.2 2 30 6 259.7 3.6 2 34 6 70.9 2.8 2 24 0 284.6 11.3 2 26 25 132.7 5.9 2 30 7 75.2 4.2 2 34 7 83.6 2.4 2 24 3 101.9 2.6 2 26 26 170.5 5.6 2 30 8 214.9 3.1 2 34 8 314.2 4.4 2 24 4 273.8 3.9 2 26 27 28.0 13.1 2 30 9 113.1 2.2 2 34 9 73.4 2.8 2 24 5 881.5 12.7 2 27 3 339.3 12.4 2 30 10 55.9 3.8 2 34 10 59.7 3.3 2 24 6 292.5 4.4 2 27 4 240.4 4.6 2 30 11 189.9 2.8 2 34 11 104.3 4.3 2 24 7 375.6 5.0 2 27 5 463.4 5.5 2 30 12 75.7 3.4 2 34 12 176.3 6.6 2 24 8 302.4 4.3 2 27 6 165.1 2.3 2 30 13 173.0 2.8 2 34 13 222.7 4.0 2 24 9 168.1 2.8 2 27 7 139.6 2.5 2 30 14 239.9 3.6 2 34 14 210.5 3.2 2 24 10 251.6 3.6 2 27 8 82.4 2.8 2 30 15 97.2 3.4 2 34 15 100.1 3.3 2 24 11 97.5 4.2 2 27 9 82.0 3.0 2 30 16 37.3 8.3 2 34 16 152.2 3.8 2 24 12 149.7 3.0 2 27 10 48.4 4.8 2 30 17 135.4 10.3 2 34 17 173.6 3.1 2 24 13 197.1 3.4 2 27 11 132.7 2.7 2 30 19 168.2 4.3 2 34 18 84.7 4.4 2 24 14 273.5 4.1 2 27 12 150.6 3.1 2 30 20 163.6 4.6 2 34 19 88.2 4.4 2 24 15 91.4 3.8 2 27 13 151.1 2.8 2 30 21 105.9 4.1 2 34 20 20.2 8.9 2 24 16 224.6 3.4 2 27 14 245.3 3.8 2 30 22 243.7 4.0 2 35 7 51.3 3.8 2 24 17 127.0 4.3 2 27 15 256.2 3.9 2 30 23 70.0 5.8 2 35 8 198.8 3.4 2 24 18 354.3 4.9 2 27 16 223.1 3.5 2 30 24 89.4 6.3 2 35 9 139.3 4.7 2 24 19 244.8 3.9 2 27 17 218.7 4.0 2 31 4 126.4 3.6 2 35 10 166.4 7.7 2 24 20 120.5 4.1 2 27 18 261.2 4.9 2 31 5 118.8 2.2 2 35 11 16.1 7.1 2 24 21 122.8 4.0 2 27 19 98.1 4.6 2 31 6 241.6 3.3 2 35 12 361.4 5.0 2 24 22 108.6 6.0 2 27 20 220.0 14.5 2 31 7 235.1 3.3 2 35 13 64.1 4.1 2 24 23 204.0 4.6 2 27 21 108.7 4.5 2 31 8 160.5 2.6 2 35 14 152.1 3.3 2 24 24 91.3 5.4 2 27 22 144.5 3.9 2 31 9 218.6 3.5 2 35 15 192.4 3.7 2 24 25 136.7 4.9 2 27 23 106.9 5.4 2 31 10 213.6 3.0 2 35 16 62.7 4.7 2 24 26 100.6 5.6 2 27 24 93.6 5.7 2 31 11 305.2 4.5 2 35 17 75.0 5.5 2 24 27 177.6 4.3 2 27 25 223.7 4.3 2 31 12 179.2 3.0 2 35 18 41.5 8.9 2 24 28 132.9 6.6 2 27 26 152.8 4.2 2 31 13 203.2 3.0 2 35 19 182.6 3.9 2 25 4 19.3 7.0 2 28 4 130.3 3.2 2 31 14 131.6 3.3 2 36 7 210.1 10.2 2 25 5 204.3 3.6 2 28 5 133.4 2.3 2 31 15 121.8 4.1 2 36 8 19.8 8.2 2 25 6 252.6 4.0 2 28 6 90.7 2.1 2 31 16 230.5 9.5 2 36 9 47.3 3.7 2 25 7 166.5 2.8 2 28 7 268.8 3.8 2 31 17 204.8 3.7 2 36 10 39.5 4.4 2 25 8 280.1 3.8 2 28 8 215.1 3.0 2 31 18 219.7 4.4 2 36 11 162.6 3.0 2 25 9 314.6 4.2 2 28 9 439.2 5.9 2 31 19 31.2 10.8 2 36 12 124.1 2.7 2 25 10 261.4 4.1 2 28 10 223.4 3.3 2 31 20 69.4 5.0 2 36 13 65.4 4.0 WO 99/10379 PCT/GB98/02542 -115 2 36 14 66.0 4.1 3 1 7 230.8 3.9 3 3 12 563.8 7.7 3 5 16 351.6 7.0 2 36 15 114.8 3.2 3 1 8 238.9 3.5 3 3 13 380.6 5.4 3 5 17 663.2 9.6 2 36 16 41.4 7.7 3 1 9 257.0 4.2 3 3 14 361.0 5.0 3 5 18 235.2 4.2 2 36 17 66.2 4.8 3 1 10 74.7 3.2 3 3 15 147.7 3.3 3 5 19 323.3 5.5 2 36 18 222.2 3.8 3 1 11 375.2 7.1 3 3 16 315.7 6.9 3 5 20 535.3 7.3 2 37 7 25.3 6.8 3 1 12 598.4 8.6 3 3 17 343.9 5.2 3 5 21 16.3 8.2 2 37 8 174.1 4.6 3 1 13 760.7 10.3 3 3 18 241.7 4.2 3 5 22 104.6 6.0 2 37 9 115.8 2.4 3 1 14 499.9 7.4 3 3 19 287.6 5.2 3 5 23 131.4 4.3 2 37 10 129.3 2.3 3 1 15 232.9 3.8 3 3 20 174.0 4.8 3 5 24 98.9 5.8 2 37 11 69.1 3.0 3 1 16 246.3 5.2 3 3 21 161.9 5.3 3 5 25 56.5 10.3 2 37 12 155.7 2.8 3 1 17 508.1 7.9 3 3 22 225.4 4.9 3 5 26 84.4 8.3 2 37 13 108.7 3.3 3 1 18 126.1 5.2 3 3 23 203.3 4.3 3 5 27 108.6 7.8 2 37 14 54.0 5.7 3 1 19 599.1 8.8 3 3 24 32.0 13.0 3 5 28 209.8 5.3 2 37 15 100.8 3.4 3 1 20 409.6 6.0 3 3 25 193.5 4.7 3 5 29 367.2 10.6 2 37 16 12.8 6.3 3 1 21 189.3 4.4 3 3 26 49.5 16.0 3 5 30 63.3 17.0 2 38 8 181.2 5.0 3 1 22 121.6 6.0 3 3 27 118.4 7.3 3 5 31 152.8 5.9 2 38 9 77.7 3.2 3 1 23 297.5 5.0 3 3 28 130.0 6.3 3 5 32 156.7 6.7 2 38 10 198.5 3.2 3 1 24 130.7 4.9 3 3 29 330.2 13.3 3 5 33 114.5 8.4 2 38 11 52.7 3.9 3 1 25 187.5 4.8 3 3 30 187.0 6.2 3 6 0 639.9 15.9 2 38 12 98.8 2.5 3 1 26 184.2 5.0 3 3 31 422.0 6.9 3 6 1 658.8 15.2 2 38 13 37.2 6.7 3 1 27 67.3 13.0 3 3 32 53.4 15.5 3 6 2 223.5 3.3 2 38 14 69.4 3.8 3 1 28 245.2 5.9 3 3 33 38.4 15.8 3 6 3 420.6 5.7 2 38 15 158.4 3.4 3 1 29 327.4 15.6 3 4 0 386.0 9.2 3 6 4 237.1 3.7 2 39 8 113.0 2.8 3 1 30 154.7 7.0 3 4 1 571.3 9.3 3 6 5 491.4 7.9 2 39 9 218.4 3.7 3 1 31 148.2 8.8 3 4 2 412.0 6.8 3 6 6 575.3 8.3 2 39 10 64.3 3.2 3 1 32 78.2 11.2 3 4 3 432.1 7.9 3 6 7 192.3 3.0 2 39 11 108.3 2.8 3 1 33 25.8 12.4 3 4 4 243.6 3.6 3 6 8 234.2 3.6 2 39 12 97.3 2.6 3 2 0 387.0 9.5 3 4 5 320.7 5.4 3 6 9 408.2 5.3 2 39 13 130.0 3.1 3 2 1 603.3 10.5 3 4 6 468.4 7.0 3 6 10 155.2 3.2 2 40 9 53.0 3.2 3 2 2 326.9 5.3 3 4 7 414.2 6.1 3 6 11 209.5 3.3 2 40 10 85.4 2.8 3 2 4 171.7 3.0 3 4 8 221.2 3.4 3 6 12 425.0 6.4 2 40 11 47.3 4.0 3 2 5 180.5 3.3 3 4 9 467.5 5.9 3 6 13 320.2 4.5 2 41 9 86.1 5.7 3 2 6 378.7 5.6 3 4 10 541.4 7.3 3 6 14 770.3 11.2 3 0 0 723.5 23.0 3 2 7 249.4 3.8 3 4 11 439.4 6.8 3 6 15 16.3 8.2 3 0 1 6.8 4.9 3 2 8 473.3 7.3 3 4 12 367.3 5.0 3 6 16 93.8 4.9 3 0 3 492.1 10.4 3 2 9 153.5 3.4 3 4 13 419.5 5.5 3 6 17 474.4 7.5 3 0 5 555.2 12.5 3 2 10 116.5 3.2 3 4 14 288.9 4.1 3 6 18 545.0 8.2 3 0 6 512.0 10.5 3 2 11 372.3 5.1 3 4 15 418.6 6.0 3 6 19 153.9 4.2 3 0 7 112.1 4.0 3 2 12 91.3 3.6 3 4 16 428.9 6.6 3 6 20 216.4 4.3 3 0 8 64.7 5.0 3 2 13 421.6 5.6 3 4 17 227.9 7.5 3 6 21 249.9 4.0 3 0 9 229.2 4.9 3 2 14 361.0 5.3 3 4 18 243.9 4.2 3 6 22 108.8 5.6 3 0 10 56.0 5.7 3 2 15 255.2 4.0 3 4 19 171.2 4.2 3 6 23 78.4 7.2 3 0 11 446.0 8.5 3 2 16 448.5 6.7 3 4 20 96.1 7.0 3 6 24 213.5 4.8 3 0 12 141.2 4.6 3 2 17 421.8 6.4 3 4 21 270.4 4.6 3 6 25 192.3 4.7 3 0 13 478.7 9.1 3 2 18 652.5 8.6 3 4 22 117.7 6.8 3 6 26 73.6 7.9 3 0 14 537.8 12.2 3 2 19 45.9 13.7 3 4 23 308.8 5.3 3 6 27 198.8 4.7 3 0 15 138.0 5.2 3 2 20 216.2 4.4 3 4 24 168.0 4.5 3 6 28 70.4 9.5 3 0 16 42.9 19.9 3 2 21 168.6 4.5 3 4 25 108.1 6.9 3 6 29 204.2 17.8 3 0 17 139.4 6.4 3 2 22 143.4 5.2 3 4 26 129.7 6.5 3 6 30 51.4 15.5 3 0 18 92.5 11.4 3 2 23 113.1 6.2 3 4 27 104.3 7.2 3 6 31 138.0 7.2 3 0 19 100.1 7.6 3 2 24 148.9 4.4 3 4 28 81.5 10.1 3 6 32 211.3 8.0 3 4) 20 67.7 12.1 3 2 25 263.4 5.2 3 4 29 470.7 12.4 3 6 33 118.3 9.3 3 0 21 349.1 7.1 3 2 26 194.2 5.0 3 4 30 233.6 5.3 3 7 0 667.7 15.1 3 0 22 145.8 7.6 3 2 27 138.4 6.4 3 4 31 136.4 7.8 3 7 1 439.5 6.4 3 0 23 14.7 11.0 3 2 28 65.8 14.3 3 4 32 93.7 10.9 3 7 2 225.8 3.3 3 0 24 195.5 6.0 3 2 29 329.9 15.1 3 4 33 181.0 6.2 3 7 3 315.2 4.6 3 0 25 302.5 8.6 3 2 30 42.9 16.0 3 5 0 201.9 3.5 3 7 4 471.8 6.0 3 0 26 15.5 11.5 3 2 31 68.0 14.8 3 5 1 653.5 11.9 3 7 5 22.7 7.3 3 0 27 117.1 9.8 3 2 32 190.9 5.4 3 5 2 534.9 10.4 3 7 6 182.4 2.7 3 0 28 88.6 11.3 3 2 33 101.9 13.8 3 5 3 482.6 8.1 3 7 7 148.2 3.1 3 0 29 181.3 13.6 3 3 0 339.3 6.1 3 5 4 314.6 5.3 3 7 8 470.5 6.7 3 0 30 127.6 12.8 3 3 1 593.9 10.5 3 5 5 29.2 7.8 3 7 9 229.2 3.3 3 0 31 137.6 10.0 3 3 2 465.1 8.6 3 5 6 317.3 4.5 3 7 10 535.3 8.0 3 0 32 383.2 9.3 3 3 3 539.5 10.1 3 5 7 257.1 3.5 3 7 11 275.5 3.8 3 0 33 57.3 23.9 3 3 4 321.6 5.0 3 5 8 197.6 3.1 3 7 12 282.4 4.0 3 1 0 278.3 6.4 3 3 5 365.9 6.4 3 5 9 52.9 6.2 3 7 13 1023.3 13.9 3 1 1 141.5 2.6 3 3 6 130.1 2.4 3 5 10 358.2 5.0 3 7 14 838.3 11.5 3 1 2 212.2 3.7 3 3 7 216.3 3.2 3 5 11 393.0 6.2 3 7 15 165.7 4.5 3 1 3 434.6 5.9 3 3 8 518.9 7.8 3 5 12 246.6 3.7 3 7 16 325.9 5.0 3 1 4 279.5 5.1 3 3 9 149.1 3.0 3 5 13 436.8 5.9 3 7 17 530.2 7.8 3 1 5 544.7 8.6 3 3 10 390.0 5.9 3 5 14 492.0 7.3 3 7 18 249.0 4.5 3 1 6 148.2 2.7 3 3 11 375.4 7.0 3 5 15 416.9 6.0 3 7 19 513.8 8.1 WO 99/10379 PCT/GB98/02542 -116 3 7 20 251.1 4.3 3 9 24 204.0 4.4 3 11 31 82.2 8.5 3 14 7 394.9 5.7 3 7 21 91.6 8.5 3 9 25 332.7 5.0 3 11 32 240.8 5.9 3 14 8 530.5 7.4 3 7 22 28.8 12.5 3 9 26 242.8 4.4 3 12 0 306.9 5.2 3 14 9 673.1 8.9 3 7 23 160.8 4.7 3 9 28 29.6 15.0 3 12 1 207.3 3.5 3 14 10 303.7 4.0 3 7 24 160.8 4.1 3 9 29 264.8 5.0 3 12 2 169.6 2.5 3 14 11 588.0 7.7 3 7 25 195.2 5.0 3 9 30 110.4 7.3 3 12 3 326.5 4.2 3 14 12 334.9 5.7 3 7 26 260.0 4.9 3 9 31 236.0 5.6 3 12 4 238.6 3.3 3 14 13 326.0 4.7 3 7 27 173.9 4.7 3 9 32 93.3 8.2 3 12 5 509.7 7.3 3 14 14 25.1 10.4 3 7 28 20.8 10.1 3 9 33 55.4 17.4 3 12 6 485.7 6.3 3 14 15 277.3 4.4 3 7 29 28.6 14.5 3 10 0 449.0 8.8 3 12 7 967.5 16.0 3 14 16 186.2 3.6 3 7 30 282.7 5.3 3 10 1 375.9 5.1 3 12 8 548.5 8.2 3 14 17 258.5 4.4 3 7 31 128.3 7.2 3 10 2 262.7 3.3 3 12 9 467.6 6.6 3 14 18 136.1 3.6 3 7 32 25.6 12.4 3 10 3 400.8 5.7 3 12 10 633.5 9.4 3 14 19 171.9 3.9 3 7 33 186.0 7.1 3 10 4 319.0 4.1 3 12 11 214.4 3.2 3 14 20 178.4 3.9 3 8 0 752.3 16.8 3 10 5 227.9 3.3 3 12 12 123.0 3.1 3 14 21 259.8 4.5 3 8 1 680.2 12.5 3 10 6 180.5 2.6 3 12 13 378.6 5.3 3 14 22 294.2 4.5 3 8 2 90.2 2.2 3 10 7 75.2 3.1 3 12 14 267.3 4.1 3 14 23 287.7 4.5 3 8 3 216.2 3.7 3 10 8 230.8 3.3 3 12 15 537.8 6.9 3 14 24 328.8 5.2 3 8 4 253.3 3.3 3 10 9 189.1 2.8 3 12 16 207.4 3.9 3 14 25 198.2 4.4 3 8 5 107.5 2.8 3 10 10 138.1 2.9 3 12 17 334.8 5.6 3 14 26 151.4 4.3 3 8 6 141.8 2.8 3 10 11 574.8 9.0 3 12 18 399.5 7.3 3 14 27 373.7 9.9 3 8 7 169.5 2.7 3 10 12 478.9 6.3 3 12 19 267.1 4.6 3 14 28 77.1 8.2 3 8 8 217.2 3.1 3 10 13 401.9 5.6 3 12 20 129.1 5.2 3 14 29 254.6 4.8 3 8 9 258.9 3.6 3 10 14 553.3 7.1 3 12 21 115.5 5.2 3 14 30 136.1 8.1 3 8 10 574.6 7.8 3 10 15 562.1 7.6 3 12 22 175.5 3.7 3 14 31 104.1 10.8 3 8 11 732.4 9.2 3 10 17 165.4 4.7 3 12 23 177.8 3.8 3 15 0 25.0 5.9 3 8 12 372.5 5.5 3 10 18 62.1 8.2 3 12 24 282.4 5.1 3 15 1 530.4 9.7 3 8 13 876.6 11.6 3 10 19 128.2 4.8 3 12 25 271.9 4.4 3 15 2 686.2 8.8 3 8 14 431.8 6.7 3 10 20 201.7 4.1 3 12 26 146.3 5.8 3 15 3 238.4 3.3 3 8 15 323.6 5.4 3 10 21 458.3 6.4 3 12 27 31.0 12.8 3 15 4 985.6 17.5 3 8 16 144.2 8.4 3 10 22 142.8 3.6 3 12 29 127.0 5.4 3 15 5 466.0 6.4 3 8 17 626.7 8.7 3 10 23 75.6 6.8 3 12 30 51.9 14.8 3 15 6 328.3 4.2 3 8 18 394.0 6.0 3 10 24 164.5 5.7 3 12 31 109.0 7.0 3 15 7 340.1 4.9 3 8 19 228.6 5.0 3 10 25 161.4 4.5 3 12 32 188.1 5.6 3 15 8 160.8 3.7 3 8 20 182.3 4.0 3 10 26 93.5 5.9 3 13 0 93.3 2.6 3 15 9 604.1 9.3 3 8 21 234.7 4.2 3 10 27 151.3 5.7 3 13 1 184.2 2.8 3 15 10 342.9 5.0 3 8 22 93.0 8.7 3 10 28 338.4 11.9 3 13 2 168.0 2.4 3 15 11 176.9 8.5 3 8 23 241.4 4.1 3 10 29 89.6 11.2 3 13 3 356.0 4.7 3 15 12 232.6 3.9 3 8 24 83.5 8.1 3 10 30 80.9 11.1 3 13 4 389.7 5.2 3 15 13 252.2 4.6 3 8 25 74.6 9.2 3 10 31 97.8 11.0 3 13 5 102.8 2.6 3 15 14 152.9 3.3 3 8 26 19.8 9.7 3 10 32 197.6 5.0 3 13 61150.5 18.9 3 15 15 100.5 4.0 3 8 27 123.6 6.1 3 11 0 434.9 6.6 3 13 7 299.1 4.2 3 15 16 383.6 5.9 3 8 28 20.0 10.0 3 11 1 282.1 3.8 3 13 8 238.1 3.2 3 15 17 147.1 4.4 3 8 29 41.3 16.0 3 11 2 385.5 6.7 3 13 9 641.6 8.3 3 15 18 223.1 3.9 3 8 30 115.8 8.0 3 11 3 186.3 2.7 3 13 10 254.1 3.6 3 15 19 165.7 4.2 3 8 31 120.6 8.4 3 11 4 133.2 2.2 3 13 11 351.5 4.8 3 15 20 174.1 3.9 3 8 32 175.1 6.0 3 11 5 153.2 2.8 3 13 12 520.2 7.1 3 15 21 279.2 4.5 3 8 33 183.8 7.0 3 11 6 125.8 2.3 3 13 13 301.1 5.4 3 15 22 131.4 3.7 3 9 0 197.1 3.3 3 11 7 318.1 4.1 3 13 14 194.1 8.0 3 15 23 254.1 4.4 3 9 1 275.9 4.1 3 11 8 790.8 10.0 3 13 15 428.5 6.0 3 15 24 113.8 6.0 3 9 2 890.9 13.0 3 11 9 850.7 12.1 3 13 16 194.2 3.8 3 15 25 212.6 5.1 3 9 3 374.5 4.7 3 11 10 704.9 10.6 3 13 17 297.5 4.3 3 15 27 274.2 6.0 3 9 4 40.3 3.6 3 11 11 401.1 5.7 3 13 18 197.3 3.8 3 15 28 136.4 5.8 3 9 5 421.8 6.5 3 11 12 568.7 7.5 3 13 19 157.4 4.6 3 15 29 44.4 15.6 3 9 6 270.2 3.8 3 11 13 329.4 4.6 3 13 20 172.1 4.0 3 15 30 206.1 4.8 3 9 7 183.5 2.7 3 11 14 368.8 5.8 3 13 21 32.9 12.6 3 15 31 144.4 5.9 3 9 8 480.4 7.1 3 11 15 268.9 4.8 3 13 22 148.3 4.2 3 16 0 308.7 6.1 3 9 9 191.8 3.5 3 11 16 47.8 9.6 3 13 23 145.5 4.0 3 16 1 311.9 5.2 3 9 10 561.5 7.9 3 11 17 137.9 5.2 3 13 24 163.9 3.9 3 16 2 453.5 6.5 3 9 11 144.0 3.1 3 11 18 142.1 3.4 3 13 25 139.0 5.2 3 16 3 139.8 2.6 3 9 12 577.9 7.8 3 11 19 298.0 4.7 3 13 26 89.9 7.7 3 16 4 506.7 6.7 3 9 13 603.4 8.9 3 11 20 203.0 3.9 3 13 28 277.2 5.2 3 16 5 144.1 2.5 3 9 14 166.8 4.5 3 11 21 157.9 5.9 3 13 29 120.0 6.6 3 16 6 239.2 4.1 3 9 15 189.4 3.8 3 11 22 257.1 4.2 3 13 30 249.1 5.4 3 16 7 133.7 2.5 3 9 16 388.2 7.0 3 11 23 395.2 7.0 3 13 32 49.4 17.1 3 16 8 330.9 4.4 3 9 17 581.6 8.5 3 11 24 170.1 4.1 3 14 0 205.9 3.8 3 16 9 422.2 6.0 3 9 18 70.1 7.7 3 11 25 157.3 5.0 3 14 1 319.5 4.9 3 16 10 536.0 7.6 3 9 19 273.3 5.2 3 11 26 101.4 6.9 3 14 2 364.6 4.8 3 16 11 281.0 3.9 3 9 20 39.4 12.7 3 11 27 61.7 11.9 3 14 3 335.3 4.3 3 16 12 327.3 5.4 3 9 21 352.1 5.7 3 11 28 200.7 12.5 3 14 4 552.4 7.6 3 16 13 306.0 4.6 3 9 22 185.4 4.0 3 11 29 119.4 6.6 3 14 5 628.3 8.5 3 16 14 198.2 3.8 3 9 23 260.3 4.3 3 11 30 133.5 5.8 3 14 6 335.6 4.5 3 16 15 169.1 3.9 WO 99/10379 PCT/GB98/02542 -117 3 16 16 251.8 4.1 3 18 25 106.3 5.9 3 21 6 629.0 9.4 3 23 19 124.9 3.5 3 16 17 88.4 6.1 3 18 26 62.5 10.3 3 21 7 479.9 5.9 3 23 20 24.7 10.4 3 16 18 425.8 5.7 3 18 27 79.2 11.0 3 21 8 345.4 4.7 3 23 21 217.8 4.0 3 16 19 275.8 4.3 3 18 28 217.5 4.4 3 21 9 86.1 4.0 3 23 22 150.4 5.1 3 16 20 231.4 4.1 3 18 29 122.3 5.8 3 21 10 178.6 3.3 3 23 23 109.2 17.4 3 16 21 147.8 4.7 3 18 30 64.1 10.5 3 21 11 208.8 3.4 3 23 24 161.2 4.5 3 16 22 193.9 4.3 3 19 0 365.2 6.6 3 21 12 215.2 4.1 3 23 25 202.5 4.3 3 16 23 372.4 6.0 3 19 I 315.0 5.3 3 21 13 277.4 5.9 3 23 26 100.0 7.3 3 16 24 221.9 4.0 3 19 2 290.8 4.6 3 21 14 285.4 4.2 3 23 27 130.5 6.1 3 16 25 62.2 11.4 3 19 3 554.4 7.6 3 21 15 118.3 3.4 3 23 28 65.4 9.7 3 16 26 259.4 6.0 3 19 4 1010.1 12.9 3 21 16 191.2 3.6 3 24 0 108.7 2.6 3 16 27 217.3 4.9 3 19 5 168.6 2.6 3 21 17 172.9 3.6 3 24 1 137.8 2.9 3 16 28 36.6 15.7 3 19 6 437.3 9.1 3 21 18 182.2 3.3 3 24 2 306.5 5.5 3 16 29 179.3 5.1 3 19 7 265.3 3.9 3 21 19 45.8 10.5 3 24 3 307.2 4.8 3 16 30 67.7 13.1 3 19 8 316.7 4.2 3 21 20 136.5 4.0 3 24 4 320.1 4.2 3 16 31 170.5 5.6 3 19 9 458.7 7.7 3 21 21 309.5 5.1 3 24 5 408.5 5.4 3 17 0 393.6 8.1 3 19 10 149.6 2.9 3 21 22 106.9 4.9 3 24 6 337.9 5.0 3 17 1 322.7 6.0 3 19 11 159.8 3.1 3 21 23 24.2 11.1 3 24 7 360.3 5.3 3 17 2 128.3 2.0 3 19 12 197.9 3.6 3 21 24 274.0 11.6 3 24 8 302.8 3.9 3 17 3 200.4 2.9 3 19 13 266.8 5.1 3 21 25 103.2 6.7 3 24 9 140.3 3.2 3 17 4 604.0 8.4 3 19 14 247.5 4.1 3 21 26 132.7 4.7 3 24 10 338.0 4.5 3 17 5 583.8 8.3 3 19 15 75.1 5.1 3 21 27 93.6 8.4 3 24 11 102.3 4.1 3 17 6 275.0 3.9 3 19 16 251.7 4.1 3 21 28 191.0 5.0 3 24 12 201.7 3.8 3 17 7 797.2 10.4 3 19 17 241.4 3.9 3 21 29 109.2 7.8 3 24 13 211.8 3.5 3 17 8 176.2 2.7 3 19 18 117.1 4.1 3 22 0 488.7 8.6 3 24 14 157.1 4.3 3 17 9 461.4 7.1 3 19 19 88.4 6.0 3 22 1 517.9 9.4 3 24 15 46.7 9.2 3 17 10 180.7 3.1 3 19 20 379.3 5.5 3 22 2 198.4 4.9 3 24 16 174.4 3.5 3 17 11 247.7 7.1 3 19 21 137.7 4.1 3 22 3 294.1 3.8 3 24 17 17.4 8.7 3 17 12 454.1 6.4 3 19 22 277.1 4.5 3 22 4 436.4 5.6 3 24 18 38.7 9.1 3 17 13 222.0 4.1 3 19 23 186.8 3.8 3 22 5 54.8 3.7 3 24 19 126.0 3.9 3 17 14 413.9 5.6 3 19 24 34.9 12.7 3 22 6 516.4 7.0 3 24 20 260.7 5.0 3 17 15 242.0 3.9 3 19 25 451.2 14.4 3 22 7 461.7 7.2 3 24 21 233.1 4.0 3 17 16 221.9 4.0 3 19 26 44.7 13.6 3 22 8 444.9 6.7 3 24 22 269.2 11.2 3 17 17 171.0 3.6 3 19 27 47.6 13.3 3 22 9 197.2 3.7 3 24 23 51.7 9.8 3 17 18 107.5 4.4 3 19 28 205.0 5.2 3 22 10 149.6 3.3 3 24 24 128.6 5.1 3 17 19 95.1 4.9 3 19 29 136.2 5.9 3 22 11 283.2 4.5 3 24 25 153.7 4.5 3 17 20 96.6 5.0 3 19 30 184.6 5.4 3 22 12 282.2 4.9 3 24 26 159.1 4.3 3 17 21 157.7 4.3 3 20 0 510.8 10.8 3 22 13 413.4 6.0 3 24 27 145.8 4.9 3 17 22 173.2 4.1 3 20 1 228.4 4.1 3 22 14 262.7 3.8 3 25 0 543.5 11.6 3 17 23 172.5 4.2 3 20 2 430.0 6.5 3 22 15 71.2 4.5 3 25 1 187.6 3.0 3 17 24 225.6 4.2 3 20 3 651.9 8.1 3 22 16 286.4 4.2 3 25 2 432.6 7.7 3 17 25 107.0 5.6 3 20 4 225.5 4.4 3 22 17 293.2 4.9 3 25 3 483.1 8.0 3 17 26 357.4 13.0 3 20 5 114.8 3.7 3 22 18 87.7 5.0 3 25 4 707.9 8.7 3 17 27 80.0 9.1 3 20 6 189.2 3.6 3 22 19 145.3 3.5 3 25 5 685.5 9.3 3 17 28 142.5 5.0 3 20 7 136.0 5.0 3 22 20 112.8 3.9 3 25 6 386.0 5.0 3 17 29 172.7 5.1 3 20 8 770.1 9.9 3 22 21 249.5 3.9 3 25 7 244.9 3.6 3 17 30 208.0 5.7 3 20 9 197.5 3.3 3 22 22 23.0 10.8 3 25 8 235.9 3.3 3 18 0 449.8 8.2 3 20 10 454.6 6.3 3 22 23 188.1 4.4 3 25 9 55.0 5.2 3 18 1 405.1 8.6 3 20 11 214.1 3.5 3 22 24 31.2 12.7 3 25 10 151.1 2.7 3 18 2 533.4 6.5 3 20 12 428.1 7.3 3 22 25 68.3 9.2 3 25 11 194.2 3.0 3 18 3 448.8 5.5 3 20 13 286.6 4.1 3 22 26 123.0 5.7- 3 25 12 391.6 5.1 3 18 4 698.5 8.8 3 20 14 254.0 4.0 3 22 27 26.9 11.8 3 25 13 296.3 4.6 3 18 5 676.8 8.8 3 20 15 112.5 4.1 3 22 28 31.2 13.5 3 25 14 353.3 5.2 3 18 6 1169.4 13.7 3 20 16 222.4 3.8 3 23 0 150.3 3.2 3 25 15 82.6 4.1 3 18 7 180.1 2.9 3 20 17 258.0 4.0 3 23 1 110.3 2.8 3 25 16 24.8 9.7 3 18 8 356.2 6.1 3 20 18 142.1 3.6 3 23 2 373.1 6.6 3 25 17 113.6 3.5 3 18 9 885.6 11.9 3 20 19 289.0 4.5 3 23 3 391.3 4.8 3 25 18 265.2 4.3 3 18 10 586.2 8.7 3 20 20 255.6 4.2 3 23 4 433.5 5.5 3 25 19 154.3 3.8 3 18 11 85.8 5.3 3 20 21 154.7 4.0 3 23 5 285.4 3.9 3 25 20 130.7 4.1 3 18 12 158.7 3.3 3 20 22 106.9 6.0 3 23 6 416.3 5.4 3 25 22 76.1 7.4 3 18 13 545.8 7.7 3 20 23 250.3 5.1 3 23 7 344.0 4.5 3 25 23 88.5 6.8 3 18 14 306.9 4.6 3 20 24 16.7 8.4 3 23 8 305.9 4.0 3 25 24 59.1 8.2 3 18 15 525.7 8.3 3 20 26 128.4 7.4 3 23 9 161.5 3.0 3 25 25 62.5 9.3 3 18 16 144.3 3.5 3 20 27 123.0 8.0 3 23 10 102.9 3.3 3 25 26 129.2 5.2 3 18 17 448.4 7.8 3 20 28 116.5 7.0 3 23 11 281.9 4.3 3 25 27 193.5 4.8 3 18 18 129.4 3.8 3 20 29 95.9 8.3 3 23 12 264.2 5.7 3 26 0 206.9 6.3 3 18 19 318.0 5.0 3 21 0 606.2 17.7 3 23 13 105.0 4.9 3 26 1 386.4 10.1 3 18 20 196.9 3.9 3 21 1 176.5 3.6 3 23 14 138.1 3.3 3 26 2 315.2 5.6 3 18 21 72.8 6.5 3 21 2 401.7 5.9 3 23 15 199.4 3.4 3 26 3 83.7 2.4 3 18 22 290.0 4.6 3 21 3 324.9 4.2 3 23 16 144.1 3.7 3 26 4 199.8 2.6 3 18 23 134.1 4.3 3 21 4 407.1 5.8 3 23 17 60.2 7.1 3 26 5 189.0 2.5 3 18 24 108.5 6.2 3 21 5 582.5 8.0 3 23 18 101.9 4.5 3 26 6 55.8 3.7 WO 99/10379 PCT/GB98/02542 -118 3 26 7 394.4 4.9 3 29 5 102.1 2.1 3 32 16 297.0 4.7 3 37 12 72.3 3.5 3 26 8 252.4 3.5 3 29 6 36.2 4.7 3 32 17 130.1 3.5 3 37 13 107.8 3.2 3 26 9 171.0 3.0 3 29 7 130.9 2.9 3 32 18 153.6 4.6 3 37 14 36.2 7.9 3 26 10 76.7 4.6 3 29 8 209.2 3.1 3 32 19 125.6 3.9 3 37 15 210.7 3.5 3 26 11 79.7 3.7 3 29 9 237.6 3.7 3 32 20 173.8 3.6 3 37 16 191.9 6.3 3 26 12 207.8 3.3 3 29 10 136.3 3.0 3 32 21 158.2 4.6 3 38 7 163.6 4.4 3 26 13 136.5 3.3 3 29 11 53.1 5.0 3 32 22 93.4 6.7 3 38 8 72.1 2.8 3 26 14 153.5 3.0 3 29 12 254.5 3.7 3 33 5 87.1 4.1 3 38 9 204.6 3.4 3 26 15 283.3 4.0 3 29 13 326.2 4.6 3 33 6 140.4 2.3 3 38 10 102.2 2.7 3 26 16 169.4 3.4 3 29 14 66.9 6.2 3 33 7 176.4 2.8 3 38 11 117.8 3.3 3 26 17 291.1 4.8 3 29 15 41.4 9.2 3 33 8 47.7 4.9 3 38 12 180.1 3.0 3 26 18 37.5 10.4 3 29 16 128.5 3.1 3 33 9 96.2 2.8 3 38 13 113.2 2.9 3 26 19 220.3 3.8 3 29 17 206.3 3.4 3 33 10 229.6 3.3 3 38 14 179.1 3.7 3 26 20 307.3 5.0 3 29 18 306.4 16.5 3 33 11 175.2 2.9 3 38 15 46.6 9.6 3 26 21 26.3 12.3 3 29 19 50.5 9.4 3 33 12 103.3 4.0 3 39 8 319.8 6.7 3 26 22 46.4 12.5 3 29 20 172.5 4.5 3 33 13 221.3 8.2 3 39 9 98.7 2.6 3 26 23 163.3 4.1 3 29 21 142.2 4.5 3 33 14 116.4 4.6 3 39 10 140.2 2.5 3 26 24 93.9 9.9 3 29 22 50.1 10.6 3 33 15 87.5 3.9 3 39 11 64.8 4.4 3 26 25 166.2 4.6 3 29 23 319.6 5.3 3 33 16 187.7 3.6 3 39 12 88.0 3.5 3 26 26 175.5 5.1 3 29 24 193.4 3.9 3 33 17 171.3 3.4 3 39 13 108.9 5.6 3 27 2 361.9 9.8 3 30 3 401.7 9.5 3 33 18 137.6 4.3 3 40 7 218.6 7.6 3 27 3 149.7 4.1 3 30 4 323.9 6.1 3 33 19 182.4 3.5 3 40 8 85.1 4.5 3 27 4 284.3 3.8 3 30 5 161.1 2.4 3 33 20 120.0 5.2 3 40 9 104.6 3.0 3 27 5 294.4 4.2 3 30 6 24.4 7.2 3 33 21 118.1 4.3 3 40 10 24.2 7.0 3 27 6 225.8 3.0 3 30 7 269.9 4.1 3 34 5 183.8 3.5 3 40 11 130.7 4.3 3 27 7 36.1 6.8 3 30 8 91.1 2.5 3 34 6 115.5 2.1 3 41 8 162.3 4.7 3 27 8 78.5 3.1 3 30 9 155.4 2.7 3 34 7 158.4 2.4 4 0 0 334.0 8.2 3 27 9 293.3 4.1 3 30 10 69.7 3.5 3 34 8 72.6 3.1 4 0 1 534.8 18.4 3 27 10 163.1 2.7 3 30 11 209.8 3.2 3 34 9 234.1 3.6 4 0 2 252.0 5.5 3 27 11 309.7 5.4 3 30 12 155.8 2.9 3 34 10 129.2 3.3 4 0 3 201.1 5.0 3 27 12 168.6 2.8 3 30 13 35.9 9.4 3 34 11 280.0 7.4 4 0 4 253.3 5.6 3 27 13 143.1 2.8 3 30 14 72.8 4.5 3 34 12 106.7 3.6 4 0 5 779.2 14.7 3 27 14 229.9 3.8 3 30 15 40.0 8.1 3 34 13 211.4 3.8 4 0 6 285.4 6.2 3 27 15 125.4 3.3 3 30 16 129.5 4.0 3 34 14 207.8 4.5 4 0 7 188.2 4.2 3 27 16 145.4 3.5 3 30 17 318.2 8.4 3 34 15 141.8 3.3 4 0 8 874.7 16.9 3 27 17 146.0 3.6 3 30 18 217.0 4.0 3 34 16 14.0 7.0 4 0 9 83.4 4.8 3 27 18 89.0 4.8 3 30 19 88.6 6.1 3 34 17 20.0 9.1 4 0 10 393.0 8.5 3 27 19 23.1 10.4 3 30 20 101.7 5.1 3 34 18 218.1 3.6 4 0 11 9.7 7.2 3 27 20 201.9 12.5 3 30 21 64.8 6.7 3 34 19 66.8 5.3 4 0 12 796.3 17.4 3 27 21 219.4 5.3 3 30 22 101.8 6.8 3 34 20 34.1 12.0 4 0 13 521.5 10.2 3 27 22 29.0 11.8 3 30 23 36.7 11.5 3 35 6 80.2 4.0 4 0 14 636.6 11.6 3 27 23 171.2 5.0 3 31 3 310.0 7.7 3 35 7 74.1 3.3 4 0 15 167.2 5.6 3 27 24 154.2 4.8 3 31 4 102.1 4.0 3 35 8 259.6 5.7 4 0 16 207.7 5.5 3 27 25 180.9 4.6 3 31 5 128.8 2.8 3 35 9 282.1 8.2 4 0 17 276.6 16.9 3 27 26 94.5 6.9 3 31 6 153.3 2.4 3 35 11 103.3 3.0 4 0 18 273.7 7.4 3 28 2 189.5 4.4 3 31 7 202.3 3.0 3 35 12 162.6 2.9 4 0 19 22.6 15.1 3 28 3 80.5 2.7 3 31 8 59.7 3.5 3 35 13 20.0 9.1 4 0 20 212.3 6.1 3 28 4 218.2 3.2 3 31 9 141.0 2.4 3 35 14 127.2 3.0 4 0 22 283.0 6.8 3 28 5 399.9 5.5 3 31 10 85.4 2.9 3 35 15 108.5 3.9 4 0 23 82.4 8.7 3 28 6 187.9 2.6 3 31 11 52.0 4.9 3 35 16 26.6 10.1 4 0 24 17.0 11.7 3 28 7 63.7 3.2 3 31 12 169.7 3.0 3 35 17 92.0 3.6 4 0 25 15.6 11.3 3 28 8 298.4 4.1 3 31 13 88.8 3.5 3 35 18 86.6 5.3 4 0 26 112.2 9.8 3 28 9 107.5 3.2 3 31 14 112.2 3.5 3 35 19 38.8 14.9 4 0 27 38.6 23.8 3 28 10 115.2 2.5 3 31 15 126.5 4.6 3 36 0 8.4 2.0 4 0 28 200.3 9.6 3 28 11 150.2 2.9 3 31 16 154.2 14.8 3 36 6 170.2 4.7 4 0 29 250.8 26.6 3 28 12 135.8 3.1 3 31 17 155.6 3.7 3 36 7 207.9 4.7 4 0 30 225.3 8.2 3 28 13 64.4 4.9 3 31 18 169.6 3.5 3 36 8 132.5 2.6 4 0 31 85.4 21.0 3 28 14 32.8 9.2 3 31 19 50.4 7.1 3 36 9 152.5 2.4 4 0 32 19.7 14.5 3 28 15 117.7 3.5 3 31 20 141.9 4.7 3 36 10 216.8 3.2 4 0 33 98.5 15.7 3 28 16 17.8 8.8 3 31 21 43.2 13.1 3 36 11 20.2 8.5 4 1 0 722.2 14.2 3 28 17 76.7 4.9 3 31 22 177.6 3.6 3 36 12 197.2 3.4 4 1 1 464.6 7.8 3 28 18 165.0 4.1 3 31 23 99.8 9.2 3 36 13 175.0 3.9 4 1 2 535.3 8.9 3 28 19 316.0 10.5 3 32 5 221.0 4.2 3 36 14 144.4 3.0 4 1 3 394.7 5.6 3 28 20 106.6 4.7 3 32 6 97.9 2.1 3 36 15 180.5 3.5 4 1 4 347.2 5.2 3 28 21 101.5 5.2 3 32 7 146.6 2.3 3 36 16 154.8 3.6 4 1 5 435.5 6.7 3 28 22 81.9 7.3 3 32 8 90.4 2.8 3 36 17 65.6 8.1 4 1 6 275.6 4.4 3 28 23 205.0 4.1 3 32 9 107.4 2.6 3 37 6 118.0 4.3 4 1 7 171.4 2.9 3 28 24 148.4 4.5 3 32 10 123.2 3.2 3 37 7 176.8 5.6 4 1 8 475.8 6.6 3 28 25 37.7 13.6 3 32 11 111.5 4.5 3 37 8 130.9 2.6 4 1 9 155.3 3.3 3 29 2 543.7 12.9 3 32 12 37.9 8.3 3 37 9 143.4 2.7 4 1 10 120.5 2.9 3 29 3 124.5 3.9 3 32 13 84.8 4.1 3 37 10 97.1 2.7 4 1 11 628.2 8.3 3 29 4 258.0 4.9 3 32 14 314.9 8.4 3 37 11 80.2 3.2 4 1 12 442.3 6.6 WO 99/10379 PCT/GB98/02542 -119 4 1 13 417.8 5.8 4 3 17 82.7 8.9 4 5 25 216.0 4.4 4 7 29 191.5 4.9 4 1 14 382.8 6.0 4 3 18 94.1 7.0 4 5 26 110.8 6.8 4 7 30 107.4 8.4 4 1 15 357.8 4.7 4 3 19 433.4 6.5 4 5 27 20.2 9.8 4 7 31 135.6 7.9 4 1 16 223.8 4.5 4 3 20 147.1 4.6 4 5 28 95.4 8.9 4 7 32 68.7 17.6 4 1 17 294.9 6.1 4 3 21 348.4 5.2 4 5 29 107.6 8.3 4 8 0 203.9 3.7 4 1 18 453.0 7.5 4 3 22 150.1 4.2 4 5 30 192.4 7.9 4 8 1 510.0 7.1 4 1 19 311.7 4.5 4 3 23 270.1 4.7 4 5 31 39.4 15.5 4 8 2 348.1 4.8 4 1 20 87.7 7.9 4 3 24 102.6 6.0 4 5 32 55.6 15.6 4 8 3 331.0 5.3 4 1 21 105.7 7.6 4 3 25 325.5 5.2 4 5 33 127.6 11.7 4 8 4 116.3 2.3 4 1 22 268.4 4.6 4 3 26 107.3 7.6 4 6 0 166.9 2.6 4 8 5 441.6 5.6 4 1 23 97.0 4.9 4 3 27 130.0 7.3 4 6 1 371.1 5.9 4 8 6 497.9 6.3 4 1 24 157.1 3.8 4 3 28 122.5 7.4 4 6 2 495.0 8.3 4 8 7 265.1 3.7 4 1 25 257.2 4.4 4 3 30 164.6 6.3 4 6 3 430.7 5.7 4 8 8 223.4 3.3 4 1 26 208.3 4.7 4 3 31 494.1 7.2 4 6 4 64.0 2.6 4 8 9 267.9 3.7 4 1 27 116.3 6.9 4 3 32 201.5 6.2 4 6 5 495.3 6.5 4 8 10 408.4 6.2 4 1 28 153.8 5.5 4 3 33 148.8 7.4 4 6 6 173.0 2.8 4 8 11 938.2 13.0 4 1 29 220.6 16.9 4 4 0 671.1 14.1 4 6 7 154.5 2.6 4 8 12 708.6 10.1 4 1 30 192.7 5.8 4 4 1 255.7 4.2 4 6 8 477.7 6.6 4 8 13 751.2 11.0 4 1 31 95.4 12.9 4 4 2 648.5 10.2 4 6 9 625.2 8.7 4 8 14 318.3 4.8 4 1 32 217.1 7.2 4 4 3 239.5 3.5 4 6 10 362.1 5.3 4 8 15 709.0 9.7 4 1 33 58.3 16.8 4 4 4 274.7 3.9 4 6 11 490.4 7.0 4 8 16 560.7 7.9 4 2 0 316.9 4.6 4 4 5 537.8 7.8 4 6 12 282.8 4.5 4 8 17 375.8 6.3 4 2 1 432.8 7.7 4 4 6 146.9 3.1 4 6 13 364.0 5.3 4 8 18 189.3 4.0 4 2 2 503.3 7.7 4 4 7 463.0 7.3 4 6 14 898.7 11.9 4 8 19 205.2 5.3 4 2 3 500.9 9.0 4 4 8 121.1 3.0 4 6 15 208.2 5.9 4 8 20 72.1 9.3 4 2 4 457.8 6.0 4 4 9 20.3 7.7 4 6 16 227.2 11.2 4 8 21 256.3 4.4 4 2 5 521.5 7.6 4 4 10 205.1 3.0 4 6 17 233.8 4.3 4 8 22 338.4 4.8 4 2 6 185.2 2.9 4 4 11 400.7 5.3 4 6 18 346.4 6.1 4 8 23 321.3 5.1 4 2 7 143.0 2.6 4 4 12 597.1 8.3 4 6 19 309.5 4.7 4 8 24 58.4 8.1 4 2 8 194.9 3.1 4 4 13 433.0 5.5 4 6 20 306.3 4.8 4 8 25 263.0 4.6 4 2 9 545.6 7.7 4 4 14 26.6 10.6 4 6 21 159.2 5.2 4 8 26 198.3 4.5 4 2 10 680.5 9.1 4 4 15 488.3 7.2 4 6 22 196.3 4.0 4 8 27 264.1 4.8 4 2 11 390.9 5.5 4 4 16 370.5 5.4 4 6 23 114.2 4.7 4 8 28 366.5 17.0 4 2 12 504.8 7.1 4 4 17 395.4 5.4 4 6 24 17.4 8.5 4 8 29 89.4 10.9 4 2 13 878.9 11.9 4 4 18 275.8 5.8 4 6 25 298.4 4.4 4 8 30 121.4 7.2 4 2 14 775.4 12.3 4 4 19 229.6 4.3 4 6 26 218.8 5.2 4 8 31 25.4 12.7 4 2 15 324.5 4.6 4 4 20 116.3 5.1 4 6 27 160.7 4.7 4 8 32 64.6 15.5 4 2 16 230.4 3.9 4 4 21 397.1 6.3 4 6 28 34.7 14.0 4 9 0 271.1 4.3 4 2 17 779.1 10.7 4 4 22 196.4 3.9 4 6 29 250.9 6.1 4 9 1 321.5 4.6 4 2 18 262.5 4.6 4 4 23 21.6 10.0 4 6 30 99.7 8.7 4 9 2 308.5 4.5 4 2 19 224.9 4.4 4 4 24 151.0 4.2 4 6 31 264.5 5.2 4 9 3 97.9 2.3 4 2 20 249.9 6.5 4 4 25 96.1 6.6 4 6 32 134.1 7.4 4 9 4 533.2 7.6 4 2 21 211.8 4.0 4 4 26 196.1 4.7 4 6 33 84.9 11.0 4 9 5 201.8 2.9 4 2 22 144.1 4.6 4 4 27 132.5 5.7 4 7 0 691.4 12.0 4 9 6 336.1 4.7 4 2 23 50.3 10.0 4 4 28 166.3 6.2 4 7 1 298.9 4.2 4 9 7 175.3 2.7 4 2 24 114.8 5.4 4 4 30 158.0 6.0 4 7 2 519.0 7.4 4 9 8 155.6 2.8 4 2 25 133.3 5.1 4 4 31 87.9 10.5 4 7 3 256.7 3.7 4 9 9 272.6 3.8 4 2 26 288.3 5.2 4 4 32 37.7 15.2 4 7 4 285.0 3.8 4 9 10 194.0 3.1 4 2 27 126.0 6.4 4 5 0 272.6 4.3 4 7 5 233.1 4.3 4 9 11 77.8 4.0 4 2 28 160.4 5.6 4 5 1 725.1 10.1 4 7 6 163.9 2.9 4 9 12 929.3 11.8 4 2 29 37.2 18.1 4 5 2 85.2 2.8 4 7 7 307.0 4.3 4 9 13 725.4 10.7 4 *2 30 124.9 7.7 4 5 3 220.7 3.6 4 7 8 174.2 3.0 4 9 14 211.0 5.6 4 2 31 153.0 8.4 4 5 4 230.2 3.5 4 7 9 332.3 5.1 4 9 15 195.5 5.6 4 2 32 28.8 13.6 4 5 5 84.1 2.6 4 7 10 345.2 4.9 4 9 16 454.9 6.0 4 2 33 181.8 6.5 4 5 6 43.4 4.5 4 7 11 400.9 5.2 4 9 17 78.4 7.0 4 3 0 69.3 2.1 4 5 7 532.8 7.5 4 7 12 603.1 8.2 4 9 18 342.7 5.2 4 3 1 140.7 3.0 4 5 8 182.3 2.9 4 7 13 430.5 5.8 4 9 19 170.4 3.9 4 3 2 364.2 5.0 4 5 9 101.7 3.1 4 7 14 407.7 5.6 4 9 20 338.3 5.7 4 3 3 444.9 7.2 4 5 10 455.2 6.3 4 7 15 316.8 4.6 4 9 21 197.5 3.9 4 3 4 50.7 4.3 4 5 11 102.3 3.5 4 7 16 239.1 7.0 4 9 22 113.5 5.1 4 3 5 173.2 2.9 4 5 12 316.7 4.8 4 7 17 200.0 4.1 4 9 23 204.5 3.8 4 3 6 357.0 5.5 4 5 13 512.3 6.6 4 7 18 243.3 5.2 4 9 24 257.2 4.4 4 3 7 318.6 5.1 4 5 14 580.6 8.0 4 7 19 123.4 5.3 4 9 25 76.0 7.4 4 3 8 45.9 5.5 4 5 15 150.8 13.7 4 7 20 319.5 5.2 4 9 26 228.5 4.2 4 3 9 452.5 6.1 4 5 16 195.2 4.6 4 7 21 147.5 3.7 4 9 27 105.2 8..5 4 3 10 325.2 4.3 4 5 17 304.1 4.3 4 7 22 274.8 4.7 4 9 28 350.4 10.2 4 3 11 184.1 3.0 4 5 18 206.9 4.8 4 7 23 181.9 3.8 4 9 29 202.2 5.6 4 3 12 321.3 4.4 4 5 19 69.5 9.3 4 7 24 168.1 3.8 4 9 30 147.4 6.8 4 3 13 426.9 5.7 4 5 20 310.5 5.2 4 7 25 95.6 6.3 4 9 31 32.4 14.5 4 3 14 518.7 7.3 4 5 21 477.0 6.9 4 7 26 239.9 4.5 4 9 32 169.3 8.3 4 3 15 419.3 6.0 4 5 22 222.3 3.9 4 7 27 164.8 6.0 4 10 0 397.8 5.8 4 3 16 185.2 3.8 4 5 23 318.8 5.0 4 7 28 86.3 20.0 4 10 1 41.6 3.6 WO 99/10379 PCT/GB98/02542 -120 4 10 2 161.8 - 2.4 4 12 8 649.9 9.6 4 14 15 155.0 3.6 4 16 23 56.9 11.5 4 10 3 446.3 6.4 4 12 9 727.0 9.8 4 14 16 208.9 3.7 4 16 24 200.1 5.2 4 10 4 191.9 2.8 4 12 10 717.8 10.4 4 14 17 525.8 7.6 4 16 25 68.3 8.1 4 10 5 219.5 3.4 4 12 11 417.9 6.3 4 14 18 200.2 4.4 4 16 26 247.1 12.7 4 10 6 287.1 4.2 4 12 12 369.3 6.3 4 14 19 171.8 4.4 4 16 27 200.5 4.8 4 10 7 126.2 2.3 4 12 13 60.2 8.7 4 14 20 130.4 4.6 4 16 28 156.3 5.3 4 10 8 486.6 6.3 4 12 14 196.8 6.4 4 14 21 16.4 8.0 4 16 29 84.0 11.5 4 10 9 355.1 4.4 4 12 15 503.2 7.4 4 14 22 110.9 4.9 4 16 30 209.0 6.7 4 10 10 193.9 3.0 4 12 16 14.8 7.5 4 14 23 182.9 3.9 4 17 0 812.7 16.4 4 10 11 239.1 3.6 4 12 17 92.8 6.7 4 14 24 25.6 10.9 4 17 1 270.7 5.4 4 10 12 803.5 12.3 4 12 18 195.1 4.0 4 14 25 225.4 4.2 4 17 2 128.3 2.5 4 10 13 315.4 4.4 4 12 19 410.7 6.0 4 14 26 27.7 12.8 4 17 3 280.2 4.0 4 10 14 358.5 5.0 4 12 20 211.1 4.3 4 14 27 116.1 7.8 4 17 4 890.8 12.1 4 10 15 429.9 6.7 4 12 21 260.1 4.3 4 14 28 31.2 13.9 4 17 5 710.4 10.1 4 10 16 421.1 6.1 4 12 22 107.8 4.7 4 14 29 40.9 14.3 4 17 6 906.6 11.6 4 10 17 333.6 6.5 4 12 23 162.9 4.0 4 14 30 167.0 5.5 4 17 7 503.0 7.3 4 10 18 256.9 4.1 4 12 24 224.6 3.9 4 14 31 23.0 11.2 4 17 8 305.7 5.1 4 10 19 69.3 7.9 4 12 25 121.8 6.2 4 15 0 193.7 4.8 4 17 9 104.5 3.5 4 10 20 126.8 4.4 4 12 26 185.4 4.6 4 15 1 96.3 3.1 4 17 10 226.8 8.8 4 10 21 204.1 3.9 4 12 27 59.2 22.4 4 15 2 1191.8 33.4 4 17 11 333.9 5.2 4 10 22 199.9 4.5 4 12 28 152.9 5.2 4 15 3 738.7 9.5 4 17 12 204.4 3.7 4 10 23 254.1 4.2 4 12 29 74.4 9.5 4 15 4 652.4 7.6 4 17 13 396.2 5.7 4 10 24 42.5 12.0 4 12 30 102.3 8.2 4 15 5 183.4 2.9 4 17 14 568.8 10.4 4 10 25 72.3 9.3 4 12 31 70.0 10.9 4 15 6 380.6 5.1 4 17 15 121.0 3.7 4 10 26 250.9 4.6 4 12 32 65.1 14.3 4 15 7 347.7 4.9 4 17 16 396.0 6.6 4 10 27 208.3 4.5 4 13 0 361.3 6.8 4 15 8 389.9 5.3 4 17 17 131.5 4.2 4 10 28 118.1 9.0 4 13 1 429.2 6.3 4 15 9 136.9 2.9 4 17 18 200.5 3.6 4 10 29 153.2 7.2 4 13 2 386.4 4.7 4 15 10 41.5 17.3 4 17 19 26.5 10.5 4 10 30 307.3 5.4 4 13 3 163.9 2.6 4 15 11 362.8 5.4 4 17 20 335.1 6.4 4 10 31 118.5 7.7 4 13 4 495.3 6.8 4 15 12 865.8 11.8 4 17 21 141.1 3.8 4 10 32 168.6 6.4 4 13 5 241.6 3.2 4 15 13 507.9 7.5 4 17 22 189.8 3.7 4 11 0 128.8 2.6 4 13 6 309.9 4.5 4 15 14 208.6 4.1 4 17 23 107.1 4.7 4 11 1 276.8 5.0 4 13 7 809.8 11.0 4 15 15 433.8 5.9 4 17 24 42.5 13.6 4 11 2 654.4 9.0 4 13 8 189.4 3.0 4 15 16 72.2 6.1 4 17 25 191.9 5.1 4 11 3 404.8 5.5 4 13 9 124.2 2.9 4 15 17 220.7 3.5 4 17 26 178.5 6.2 4 11 4 97.8 2.2 4 13 10 649.2 8.3 4 15 18 145.9 3.9 4 17 27 78.0 7.5 4 11 5 159.2 2.6 4 13 11 299.5 4.4 4 15 19 44.0 10.7 4 17 28 135.7 5.8 4 11 6 378.4 4.7 4 13 12 524.0 6.9 4 15 20 287.7 4.4 4 17 29 80.7 9.2 4 11 7 516.1 6.9 4 13 13 224.0 4.6 4 15 21 186.4 3.9 4 17 30 111.1 7.8 4 11 8 319.4 4.7 4 13 14 430.0 6.0 4 15 22 222.4 4.0 4 18 0 186.5 3.8 4 11 9 598.3 9.6 4 13 15 211.6 3.8 4 15 23 209.3 3.9 4 18 1 466.4 8.2 4 11 10 692.6 11.6 4 13 16 91.3 5.3 4 15 24 115.7 4.7 4 18 2 400.2 6.9 4 11 11 395.5 5.3 4 13 17 260.3 4.5 4 15 25 217.2 4.3 4 18 3 405.1 5.8 4 11 12 264.8 4.4 4 13 18 98.3 6.1 4 15 26 70.8 21.3 4 18 4 328.6 4.2 4 11 13 114.9 6.8 4 13 19 213.6 4.1 4 15 27 80.5 10.8 4 18 5 94.0 2.6 4 11 14 303.0 5.1 4 13 20 125.5 4.2 4 15 28 263.3 5.0 4 18 6 536.8 7.3 4 11 15 446.7 6.3 4 13 21 171.3 4.0 4 15 29 171.4 5.9 4 18 7 194.0 4.1 4 11 16 202.8 4.7 4 13 22 101.1 6.2 4 15 30 26.3 12.2 4 18 8 101.7 2.9 4 11 17 161.4 6.4 4 13 23 199.9 4.6 4 15 31 117.2 7.9 4 18 9 622.5 9.2 4 11 18 367.8 5.5 4 13 24 132.4 6.4 4 16 0 446.3 7.1 4 18 10 295.9 4.5 4 11 19 273.4 4.9 4 13 25 20.6 9.8 4 16 1 256.4 4.4 4 18 11 606.0 8.8 4 fl 20 147.9 4.0 4 13 26 28.0 12.8 4 16 2 544.1 7.6 4 18 12 231.8 5.0 4 11 21 432.7 6.4 4 13 27 207.6 14.2 4 16 3 302.8 4.0 4 18 13 210.4 3.6 4 11 22 150.5 4.1 4 13 28 245.4 5.0 4 16 4 426.5 5.8 4 18 14 182.9 3.5 4 11 23 172.6 4.0 4 13 29 108.1 7.3 4 16 5 377.5 5.7 4 18 15 195.7 4.0 4 11 24 385.8 5.5 4 13 30 64.2 12.9 4 16 6 431.8 5.2 4 18 16 265.6 4.0 4 11 25 185.0 5.0 4 13 31 129.2 7.8 4 16 7 82.5 4.2 4 18 17 162.1 3.8 4 11 26 307.0 4.7 4 14 0 37.0 3.8 4 16 8 82.4 3.2 4 18 18 57.6 6.0 4 11 27 165.2 4.9 4 14 1 489.0 8.6 4 16 9 326.5 5.9 4 18 19 240.5 4.0 4 11 28 23.2 10.9 4 14 2 138.8 2.6 4 16 10 222.7 3.6 4 18 20 226.4 4.0 4 11 29 170.0 5.5 4 14 3 178.8 2.7 4 16 11 276.6 6.1 4 18 21 60.7 7.8 4 11 30 108.3 7.2 4 14 4 491.7 8.1 4 16 12 141.9 3.6 4 18 22 219.8 4.7 4 11 31 137.3 5.8 4 14 5 807.4 10.5 4 16 13 285.9 4.5 4 18 23 163.3 4.5 4 11 32 37.1 14.4 4 14 6 752.6 10.5 4 16 14 368.6 5.6 4 18 24 206.8 4.2 4 12 0 161.5 3.6 4 14 7 127.4 2.6 4 16 15 217.6 3.9 4 18 25 262.4 8.5 4 12 1 313.2 5.1 4 14 8 512.4 6.6 4 16 16 471.0 6.2 4 18 26 189.5 5.9 4 12 2 339.6 4.3 4 14 9 347.1 5.5 4 16 17 218.4 3.8 4 18 27 254.4 6.9 4 12 3 227.3 3.5 4 14 10 703.7 10.2 4 16 18 177.6 3.7 4 18 28 63.6 11.6 4 12 4 520.8 6.2 4 14 11 413.1 6.6 4 16 19 269.6 4.1 4 18 29 134.0 6.6 4 12 5 164.3 2.7 4 14 12 327.9 5.2 4 16 20 58.9 7.7 4 18 30 83.5 9.3 4 12 6 306.8 4.5 4 14 13 101.8 7.2 4 16 21 212.5 3.7 4 19 0 334.1 5.6 4 12 7 420.7 6.3 4 14 14 234.6 3.9 4 16 22 356.4 5.1 4 19 1 429.4 7.3 WO 99/10379 PCT/GB98/02542 -121 4 19 2 261.7 3.7 4 21 14 337.3 5.0 4 24 0 95.7 3.6 4 26 17 84.0 4.7 4 19 3 241.8 3.4 4 21 15 122.8 3.2 4 24 1 103.0 2.8 4 26 18 52.6 7.6 4 19 4 563.1 8.2 4 21 16 63.2 5.9 4 24 2 203.8 4.2 4 26 19 223.0 3.9 4 19 5 405.0 5.7 4 21 17 105.9 4.2 4 24 3 203.6 3.1 4 26 20 321.2 11.6 4 19 6 347.9 6.1 4 21 18 134.4 3.4 4 24 4 556.8 7.6 4 26 21 103.3 5.6 4 19 7 190.8 3.7 4 21 19 89.3 5.7 4 24 5 502.8 6.7 4 26 22 138.3 4.6 4 19 8 335.5 5.9 4 21 20 165.6 4.1 4 24 6 321.9 4.5 4 26 23 88.5 7.1 4 19 9 198.2 3.2 4 21 21 253.0 4.1 4 24 7 314.5 4.0 4 26 24 108.7 5.3 4 19 10 238.3 3.8 4 21 22 183.7 4.1 4 24 8 144.9 2.7 4 26 25 105.5 5.5 4 19 11 400.6 5.9 4 21 23 143.5 5.2 4 24 9 381.6 6.2 4 26 26 95.1 10.0 4 19 12 490.7 6.4 4 21 24 21.6 10.2 4 24 10 137.1 3.2 4 27 0 267.6 4.8 4 19 13 187.3 3.5 4 21 25 224.6 4.4 4 24 11 211.1 3.4 4 27 1 81.2 5.4 4 19 14 30.9 10.2 4 21 26 105.0 7.6 4 24 12 244.2 3.8 4 27 2 303.5 5.8 4 19 15 98.6 4.3 4 21 27 156.2 6.7 4 24 13 261.4 4.7 4 27 3 201.1 3.7 4 19 16 230.5 3.6 4 21 28 149.6 5.8 4 24 14 42.6 9.7 4 27 4 358.4 5.5 4 19 17 235.1 3.9 4 22 0 190.2 3.9 4 24 15 104.9 3.4 4 27 5 33.4 7.1 4 19 18 143.2 3.8 4 22 1 52.5 5.5 4 24 16 168.5 3.2 4 27 6 130.6 2.3 4 19 19 196.2 3.9 4 22 2 227.2 4.3 4 24 17 148.8 3.3 4 27 7 201.6 3.2 4 19 20 417.7 6.0 4 22 3 488.0 6.3 4 24 18 202.5 3.4 4 27 8 201.7 3.1 4 19 21 41.9 14.5 4 22 4 119.5 2.4 4 24 19 171.2 4.3 4 27 9 381.2 5.4 4 19 22 96.8 5.4 4 22 5 749.7 9.5 4 24 20 72.1 5.4 4 27 10 15.8 7.4 4 19 23 77.7 6.7 4 22 6 300.2 4.6 4 24 21 125.0 4.9 4 27 11 130.9 3.4 4 19 24 62.0 15.2 4 22 7 90.7 3.8 4 24 22 135.9 5.9 4 27 12 44.6 6.1 4 19 25 28.9 13.2 4 22 8 135.7 2.7 4 24 23 139.6 5.0 4 27 13 141.2 3.2 4 19 26 77.5 7.3 4 22 9 218.9 3.5 4 24 24 154.5 5.1 4 27 14 221.0 3.8 4 19 27 139.1 5.6 4 22 10 84.5 3.4 4 24 25 107.5 5.5 4 27 15 142.6 3.3 4 19 28 52.2 15.8 4 22 11 227.1 3.5 4 24 26 67.9 12.2 4 27 16 160.8 3.3 4 19 29 131.6 6.1 4 22 12 83.6 4.3 4 24 27 24.8 11.5 4 27 17 137.7 3.8 4 20 0 583.8 11.1 4 22 13 91.6 4.9 4 25 0 162.7 3.0 4 27 18 185.6 3.6 4 20 1 265.4 5.6 4 22 14 40.7 7.9 4 25 1 274.8 5.1 4 27 19 196.5 10.3 4 20 2 320.7 5.9 4 22 15 102.4 3.3 4 25 2 387.5 6.4 4 27 20 105.8 5.0 4 20 3 401.5 5.5 4 22 16 128.1 4.2 4 25 3 209.8 3.3 4 27 21 141.3 3.9 4 20 4 488.6 6.8 4 22 17 194.6 3.3 4 25 4 548.3 7.0 4 27 22 115.0 5.1 4 20 5 544.7 7.4 4 22 18 305.2 4.4 4 25 5 565.0 7.7 4 27 23 164.7 4.3 4 20 6 320.1 5.1 4 22 19 206.0 3.7 4 25 6 391.3 5.6 4 27 24 236.4 4.6 4 20 7 466.9 5.7 4 22 20 76.6 5.6 4 25 7 162.9 3.4 4 27 25 186.0 4.5 4 20 8 29.5 8.4 4 22 21 80.1 6.4 4 25 8 170.9 3.1 4 28 0 314.1 5.6 4 20 9 276.3 4.8 4 22 22 187.4 4.3 4 25 9 216.5 3.3 4 28 1 313.5 5.5 4 20 10 394.0 5.7 4 22 23 418.1 19.4 4 25 10 65.4 4.0 4 28 2 294.1 5.3 4 20 11 581.6 8.7 4 22 24 170.3 4.7 4 25 11 81.7 3.4 4 28 3 83.9 3.2 4 20 12 237.8 3.7 4 22 25 196.5 4.5 4 25 12 282.6 4.9 4 28 4 192.2 3.1 4 20 13 483.4 7.0 4 22 26 48.7 12.8 4 25 13 76.8 4.3 4 28 5 243.8 3.3 4 20 14 145.6 3.8 4 22 27 92.2 8.5 4 25 14 210.1 3.5 4 28 6 182.1 2.6 4 20 15 172.9 3.2 4 22 28 33.4 14.1 4 25 15 128.5 3.5 4 28 7 220.6 3.0 4 20 16 41.1 9.2 4 23 0 100.4 3.8 4 25 16 285.5 4.6 4 28 8 199.5 3.2 4 20 17 224.2 4.3 4 23 1 129.1 5.4 4 25 17 295.1 5.7 4 28 9 19.1 7.7 4 20 18 185.2 3.6 4 23 2 383.7 6.2 4 25 18 205.9 3.6 4 28 10 49.3 5.6 4 20 19 216.3 3.7 4 23 3 561.3 9.6 4 25 19 177.3 3.5 4 28 11 180.5 3.3 4 20 20 79.4 5.5 4 23 4 470.5 6.6 4 25 20 254.0 4.9 4 28 12 127.1 2.8 4 20 21 39.7 11.2 4 23 5 371.3 5.4 4 25 21 653.5 23.0 4 28 13 198.0 3.4 4 20 22 157.5 4.5 4 23 6 287.4 4.0 4 25 22 68.4 7.4 4 28 14 64.5 4.7 4 20 23 251.7 5.0 4 23 7 137.8 2.5 4 25 23 47.3 13.0 4 28 15 12.6 6.4 4 20 24 387.1 12.0 4 23 8 236.1 3.4 4 25 24 127.1 6.2 4 28 16 105.8 3.9 4 20 25 175.4 5.7 4 23 9 28.4 9.6 4 25 25 102.3 7.2 4 28 17 260.9 5.1 4 20 26 198.8 4.9 4 23 10 14.4 6.8 4 25 26 30.2 11.9 4 28 18 184.9 7.5 4 20 27 134.9 5.3 4 23 11 47.6 6.6 4 26 0 334.8 5.7 4 28 19 96.3 8.2 4 20 28 96.9 6.8 4 23 12 219.2 3.4 4 26 1 553.0 10.8 4 28 20 125.8 4.3 4 20 29 92.5 11.8 4 23 13 132.4 3.4 4 26 2 185.9 3.6 4 28 21 150.6 4.1 4 21 0 460.4 9.0 4 23 14 170.3 3.3 4 26 3 59.6 3.8 4 28 22 32.4 11.5 4 21 1 352.8 8.2 4 23 15 251.0 3.7 4 26 4 266.2 4.3 4 28 23 133.3 5.3 4 21 2 380.2 7.2 4 23 16 253.0 3.9 4 26 5 106.9 2.4 4 28 24 156.4 5.1 4 21 3 257.7 4.3 4 23 17 110.9 3.4 4 26 6 235.9 3.2 4 29 0 56.5 3.2 4 21 4 323.6 5.8 4 23 18 184.0 3.4 4 26 7 157.9 3.0 4 29 1 238.3 4.6 4 21 5 811.8 11.8 4 23 19 67.5 6.0 4 26 8 104.0 2.9 4 29 2 274.4 4.9 4 21 6 295.3 4.3 4 23 20 58.1 9.0 4 26 9 57.9 5.0 4 29 3 242.1 4.6 4 21 7 366.8 4.6 4 23 21 121.9 4.9 4 26 10 391.2 5.3 4 29 4 144.7 2.8 4 21 8 134.5 2.9 4 23 22 339.8 7.4 4 26 11 198.8 3.2 4 29 5 295.1 3.9 4 21 9 282.2 4.2 4 23 23 85.3 6.5 4 26 12 103.4 3.8 4 29 6 300.6 4.3 4 21 10 181.4 3.6 4 23 24 130.6 5.6 4 26 13 272.5 4.2 4 29 7 205.4 3.1 4 21 11 245.7 3.6 4 23 25 249.4 4.8 4 26 14 83.6 4.6 4 29 8 114.5 2.5 4 21 12 262.9 3.8 4 23 26 73.2 8.6 4 26 15 232.8 3.5 4 29 9 49.8 5.4 4 21 13 278.2 4.0 4 23 27 72.3 10.2 4 26 16 285.1 4.2 4 29 10 214.8 3.6 WO 99/10379 PCT/GB98/02542 -122 4 29 11 45.1 6.7 4 32 11 112.1 3.0 4 36 13 58.4 6.8 5 1 5 110.7 2.5 4 29 12 96.7 3.1 4 32 12 137.7 3.0 4 36 14 24.6 10.2 5 1 6 313.7 4.2 4 29 13 249.0 3.6 4 32 13 38.1 13.4 4 36 15 238.6 4.1 5 1 7 317.7 4.4 4 29 14 15.8 7.7 4 32 14 246.2 8.4 4 36 16 31.3 10.7 5 1 8 235.3 3.5 4 29 15 16.4 8.0 4 32 15 35.3 11.6 4 36 17 26.2 10.7 5 1 9 435.8 5.6 4 29 16 64.9 5.7 4 32 16 17.6 8.7 4 37 4 312.5 14.9 5 1 10 141.7 2.9 4 29 17 209.9 6.9 4 32 17 133.0 3.9 4 37 6 311.2 5.3 5 1 11 333.2 4.5 4 29 18 59.2 11.5 4 32 18 150.7 4.9 4 37 7 96.1 2.7 5 1 12 227.9 3.7 4 29 19 214.7 4.9 4 32 19 34.6 13.5 4 37 8 74.9 3.3 5 1 13 349.0 5.3 4 29 20 72.7 6.3 4 32 20 18.6 8.8 4 37 9 90.5 3.2 5 1 14 445.9 6.3 4 29 21 140.8 5.1 4 32 21 36.3 11.4 4 37 10 29.6 9.2 5 1 15 465.6 7.2 4 29 22 27.7 12.6 4 33 1 257.1 7.6 4 37 11 59.4 5.2 5 1 16 595.9 8.9 4 29 23 242.6 4.7 4 33 2 157.4 4.1 4 37 12 98.2 3.5 5 1 17 310.1 4.4 4 29 24 184.0 4.7 4 33 3 128.4 4.0 4 37 13 185.7 4.1 5 1 18 493.0 7.1 4 30 0 297.8 4.8 4 33 4 87.1 3.0 4 37 14 104.3 3.7 5 1 19 280.0 4.5 4 30 1 187.0 4.9 4 33 5 231.3 4.3 4 37 15 144.9 3.4 5 1 20 82.7 6.1 4 30 2 88.5 2.7 4 33 6 246.2 3.6 4 38 6 77.8 2.8 5 1 21 131.7 7.1 4 30 3 91.6 3.1 4 33 7 267.4 4.1 4 38 7 163.9 2.6 5 1 22 150.9 5.1 4 30 4 109.5 2.4 4 33 8 103.9 2.7 4 38 8 148.9 2.5 5 1 23 208.0 3.9 4 30 5 262.9 3.6 4 33 9 18.8 7.9 4 38 9 236.7 3.7 5 1 24 61.9 11.3 4 30 6 231.4 3.0 4 33 10 72.3 3.7 4 38 10 206.1 3.3 5 1 25 94.0 7.7 4 30 7 181.0 2.9 4 33 11 117.0 3.2 4 38 11 122.4 3.1 5 1 26 106.4 6.4 4 30 8 164.4 2.6 4 33 12 220.6 6.8 4 38 12 162.5 3.0 5 127 141.6 5.1 4 30 9 147.3 2.6 4 33 14 96.8 4.7 4 38 13 117.3 3.5 5 1 29 319.9 5.4 4 30 10 120.1 2.9 4 33 15 110.2 3.7 4 38 14 52.6 7.9 5 1 30 60.7 16.9 4 30 11 169.5 3.3 4 33 16 88.7 5.7 4 39 6 90.2 2.8 5 1 31 162.3 9.8 4 30 12 82.2 3.9 4 33 17 160.3 4.2 4 39 7 211.6 4.5 5 1 32 100.6 12.8 4 30 13 196.0 3.2 4 33 18 156.2 3.8 4 39 8 159.6 3.3 5 2 0 300.9 4.1 4 30 14 151.3 3.4 4 33 19 149.7 3.9 4 39 9 81.0 3.4 5 2 1 94.3 2.5 4 30 15 151.6 3.4 4 33 20 64.8 8.0 4 39 10 163.9 3.0 5 2 2 235.1 3.6 4 30 16 219.8 16.0 4 34 1 263.2 7.2 4 39 11 104.7 2.9 5 2 3 217.5 3.2 4 30 17 210.8 3.8 4 34 4 144.9 3.9 4 39 12 133.1 3.3 5 2 4 344.6 5.8 4 30 18 94.4 5.8 4 34 5 115.6 4.3 4 40 6 162.2 7.5 5 2 5 640.2 8.4 4 30 19 121.1 5.1 4 34 6 25.4 8.0 4 40 8 182.2 3.2 5 2 6 256.8 3.7 4 30 20 148.9 4.3 4 34 7 118.7 3.2 4 40 10 49.9 6.4 5 2 7 844.6 11.4 4 30 21 66.7 6.8 4 34 8 164.2 3.4 4 41 7 122.4 4.5 5 2 8 298.9 4.1 4 30 22 72.4 9.7 4 34 9 24.6 9.6 5 0 0 49.1 3.8 5 2 9 403.8 5.9 4 30 23 184.9 5.9 4 34 10 261.0 11.4 5 0 1 246.7 5.5 5 2 10 317.0 4.9 4 31 0 23.4 8.6 4 34 11 108.0 5.0 5 0 2 174.9 4.2 5 2 11 500.5 6.8 4 31 1 61.1 2.6 4 34 12 88.2 3.8 5 0 3 44.3 7.9 5 2 12 388.9 5.6 4 31 2 165.1 3.6 4 34 13 145.2 3.2 5 0 4 69.1 5.6 5 2 13 606.5 8.4 4 31 3 217.7 4.1 4 34 14 163.0 3.5 5 0 5 280.6 5.8 5 2 14 259.4 4.0 4 31 4 222.8 4.4 4 34 15 124.0 4.2 5 0 6 1070.6 28.4 5 2 15 443.2 6.3 4 31 5 196.1 3.3 4 34 16 129.9 4.0 5 0 7 150.1 3.8 5 2 16 482.4 7.3 4 31 6 220.5 3.7 4 34 17 102.8 4.7 5 0 8 732.5 15.4 5 2 17 527.0 7.3 4 31 7 160.7 2.7 4 34 18 30.0 11.3 5 0 9 353.4 7.1 5 2 18 406.6 6.2 4 31 8 76.6 2.8 4 34 19 97.1 4.5 5 0 10 82.7 5.1 5 2 19 85.2 6.2 4 31 9 107.4 3.0 4 35 0 128.0 3.9 5 0 11 14.4 10.0 5 2 20 322.5 5.2 4 31 10 253.1 3.8 4 35 4 103.6 4.6 5 0 12 15.5 11.2 5 2 21 214.0 5.9 4 31 11 203.6 2.9 4 35 5 71.5 3.8 5 0 13 19.8 12.7 5 2 22 155.4 7.0 4 31 12 91.6 3.2 4 35 6 253.7 5.0 5 0 14 578.0 11.4 5 2 23 304.8 4.7 4 3.1 13 175.1 3.9 4 35 7 94.6 9.5 5 0 15 481.4 10.1 5 2 24 62.2 10.0 4 31 14 23.7 10.2 4 35 8 186.0 7.4 5 0 16 265.8 19.6 5 2 25 213.3 4.2 4 31 15 261.6 8.4 4 35 9 215.3 4.5 5 0 17 240.5 5.9 5 2 26 73.8 12.0 4 31 16 51.1 9.6 4 35 10 165.0 3.5 5 0 18 263.0 6.8 5 2 27 165.8 5.0 4 31 17 70.3 5.8 4 35 11 199.2 3.9 5 0 19 16.3 11.7 5 2 28 76.9 19.8 4 31 18 85.2 6.1 4 35 12 167.0 3.4 5 0 20 21.9 13.8 5 2 29 71.8 16.4 4 31 19 66.2 9.2 4 35 13 223.7 3.8 5 0 21 176.2 5.4 5 2 30 109.4 9.3 4 31 20 49.2 13.1 4 35 14 150.0 3.5 5 0 22 63.6 13.9 5 2 31 177.1 6.5 4 31 21 13.7 6.9 4 35 15 33.2 11.3 5 0 23 152.1 5.9 5 2 32 269.8 6.0 4 31 22 16.2 8.1 4 35 16 42.5 13.0 5 0 24 89.9 17.5 5 3 0 769.8 17.4 4 32 0 131.8 3.6 4 35 17 72.5 6.6 5 0 25 12.9 9.5 5 3 1 196.4 3.2 4 32 1 87.2 3.6 4 35 18 116.0 6.2 5 0 26 129.1 7.0 5 3 2 307.2 6.1 4 32 2 191.6 5.6 4 36 4 251.5 8.3 5 0 27 68.5 14.0 5 3 3 139.2 3.0 4 32 3 242.1 6.0 4 36 5 137.7 10.6 5 0 30 56.1 28.9 5 3 4 218.7 4.0 4 32 4 142.9 3.2 4 36 6 216.3 4.3 5 0 31 29.4 20.1 5 3 5 144.7 3.0 4 32 5 172.4 3.1 4 36 7 212.3 3.4 5 0 32 330.4 10.1 5 3 6 234.7 3.4 4 32 6 184.4 2.8 4 36 8 248.6 3.6 5 1 0 468.3 7.0 5 3 7 43.6 5.5 4 32 7 147.4 2.6 4 36 9 84.3 4.1 5 1 1 435.9 6.6 5 3 8 349.2 4.6 4 32 8 112.8 2.6 4 36 10 60.3 4.9 5 1 2 334.9 6.6 5 3 9 615.3 9.9 4 32 9 150.4 2.8 4 36 11 126.2 3.0 5 1 3 437.9 6.8 5 3 10 140.9 3.1 4 32 10 86.0 3.5 4 36 12 186.3 3.2 5 1 4 248.8 3.4 5 3 11 299.9 4.4 WO 99/10379 PCT/GB98/02542 -123 5 3 12 453.8 6.4 5 5 18 75.0 9.2 5 7 24 176.2 4.2 5 9 31 31.3 14.5 5 3 13 382.1 5.2 5 5 19 442.1 6.0 5 7 25 45.5 13.2 5 9 32 41.2 16.7 5 3 14 91.9 5.0 5 5 20 258.1 4.6 5 7 26 297.2 4.8 5 10 0 274.0 4.5 5 3 15 290.4 5.1 5 5 21 265.7 4.7 5 7 27 118.3 7.5 5 10 1 466.6 8.2 5 3 16 239.4 6.9 5 5 22 76.7 8.2 5 7 28 246.4 11.8 5 10 2 278.3 4.1 5 3 17 167.6 3.8 5 5 23 30.0 11.9 5 7 29 118.3 9.3 5 10 3 221.1 3.4 5 3 18 176.9 4.3 5 5 24 113.4 8.1 5 7 30 141.3 9.1 5 10 4 519.7 7.7 5 3 19 394.5 6.1 5 5 25 236.3 4.2 5 7 31 117.3 8.4 5 10 5 220.0 3.4 5 3 20 30.1 11.5 5 5 26 160.8 4.8 5 7 32 92.9 12.2 5 10 6 122.7 3.1 5 3 21 243.8 4.4 5 5 27 79.1 9.6 5 8 0 232.5 3.9 5 10 7 57.5 3.5 5 3 22 334.3 4.9 5 5 28 357.7 8.8 5 8 1 426.4 6.4 5 10 8 552.7 7.2 5 3 23 66.2 9.1 5 5 29 73.0 14.7 5 8 2 345.1 4.8 5 10 9 271.9 3.8 5 3 24 149.1 4.6 5 5 30 178.6 7.7 5 8 3 96.4 2.6 5 10 10 503.4 6.6 5 3 25 135.8 4.6 5 5 31 97.9 10.3 5 8 4 67.8 3.3 5 10 11 280.8 4.1 5 3 26 66.6 8.0 5 5 32 144.7 8.8 5 8 5 239.2 4.0 5 10 12 439.1 5.5 5 3 27 55.4 14.6 5 6 0 493.8 7.7 5 8 6 200.8 3.0 5 10 13 448.4 6.5 5 3 28 128.6 16.1 5 6 1 185.2 2.7 5 8 7 340.6 4.9 5 10 14 312.5 7.3 5 3 29 175.6 6.0 5 6 2 423.8 6.1 5 8 8 387.0 4.9 5 10 15 286.2 4.4 5 3 30 200.4 9.0 5 6 3 159.3 2.5 5 8 9 234.5 3.4 5 10 16 192.0 3.9 5 3 31 190.4 6.5 5 6 4 43.9 4.6 5 8 10 390.2 6.7 5 10 17 214.1 4.0 5 3 32 168.4 9.2 5 6 5 166.0 2.7 5 8 11 226.1 3.8 5 10 18 234.5 4.0 5 4 0 227.1 3.5 5 6 6 377.1 5.0 5 8 12 260.7 4.0 5 10 19 185.3 3.9 5 4 1 821.5 13.0 5 6 7 314.4 4.2 5 8 13 267.1 4.4 5 10 20 29.0 12.2 5 4 2 162.6 2.9 5 6 8 603.7 8.3 5 8 14 522.5 7.0 5 10 21 314.2 4.6 5 4 3 191.2 2.9 5 6 9 268.5 4.1 5 8 15 183.5 5.8 5 10 22 445.3 6.6 5 4 4 308.0 4.0 5 6 10 502.9 7.8 5 8 16 328.7 5.1 5 10 23 125.7 5.0 5 4 5 284.5 3.8 5 6 11 458.2 6.4 5 8 17 536.7 8.6 5 10 24 207.7 3.9 5 4 6 338.3 4.6 5 6 12 486.6 7.3 5 8 18 142.0 6.8 5 10 25 212.3 4.5 5 4 7 325.3 4.6 5 6 13 151.7 3.3 5 8 19 209.2 4.1 5 10 26 131.7 5.1 5 4 8 579.7 8.7 5 6 14 305.1 5.8 5 8 20 271.3 4.4 5 10 27 219.0 10.7 5 4 9 187.7 3.3 5 6 15 206.9 4.8 5 8 21 110.2 4.9 5 10 28 244.0 5.1 5 4 10 164.1 3.9 5 6 16 215.9 4.2 5 8 22 210.4 6.0 5 10 29 166.8 5.0 5 4 11 126.6 3.4 5 6 17 218.2 4.3 5 8 23 20.7 9.7 5 10 30 145.1 7.0 5 4 12 806.8 9.6 5 6 18 221.1 4.2 5 8 24 153.0 4.8 5 10 31 59.2 18.4 5 4 13 290.9 4.6 5 6 19 380.1 5.7 5 8 25 244.4 5.2 5 10 32 79.4 17.3 5 4 14 384.1 5.5 5 6 20 78.1 5.9 5 8 26 108.9 5.7 5 11 0 226.1 3.6 5 4 15 726.4 12.6 5 6 21 192.2 4.6 5 8 27 68.9 9.5 5 11 1 241.7 3.6 5 4 16 409.1 6.0 5 6 22 217.6 4.0 5 8 28 144.3 10.2 5 11 2 348.4 4.7 5 4 17 391.8 6.1 5 6 23 210.3 3.9 5 8 29 244.0 5.3 5 11 3 350.9 5.0 5 4 18 318.0 5.3 5 6 24 108.1 7.9 5 8 30 56.4 20.6 5 11 4 181.5 2.7 5 4 19 153.5 4.4 5 6 25 192.1 4.4 5 8 31 30.8 13.8 5 11 5 285.2 3.9 5 4 20 332.8 5.5 5 6 26 312.2 5.4 5 8 32 49.8 18.3 5 11 6 594.7 8.4 5 4 21 267.3 5.3 5 6 27 128.0 7.3 5 9 0 128.4 2.8 5 11 7 518.2 7.6 5 4 22 144.2 6.3 5 6 28 367.4 13.0 5 9 1 172.5 3.0 5 11 8 290.3 4.4 5 4 23 21.4 9.9 5 6 29 186.4 5.3 5 9 2 384.3 5.8 5 11 9 485.0 6.4 5 4 24 32.2 13.3 5 6 30 143.1 7.6 5 9 3 170.4 2.6 5 11 10 166.8 2.9 5 4 25 150.8 4.6 5 6 31 103.0 10.0 5 9 4 274.3 3.9 5 11 11 309.1 4.7 5 4 26 69.6 9.0 5 6 32 118.7 12.4 5 9 5 151.4 2.5 5 11 12 121.2 6.3 5 4 27 48.0 12.9 5 7 0 233.0 3.8 5 9 6 155.1 2.7 5 11 13 292.8 4.9 5 4 28 176.2 15.8 5 7 1 232.4 3.4 5 9 7 311.1 4.2 5 11 14 222.9 4.7 5 4 29 83.8 9.9 5 7 2 227.8 3.2 5 9 8 267.5 4.7 5 11 15 81.2 5.1 5 -4 30 227.9 5.9 5 7 3 227.2 3.4 5 9 9 595.2 9.1 5 11 16 373.0 5.9 5 4 31 162.7 7.9 5 7 4 231.8 4.3 5 9 10 279.3 4.1 5 11 17 57.9 9.5 5 4 32 117.6 9.6 5 7 5 164.2 3.1 5 9 11 539.4 8.1 5 11 18 325.6 5.3 5 5 0 235.6 4.3 5 7 6 548.7 7.3 5 9 12 664.8 10.5 5 11 19 275.6 4.4 5 5 1 564.7 7.8 5 7 7 299.1 4.1 5 9 13 437.8 5.8 5 11 20 159.5 3.9 5 5 2 94.4 2.5 5 7 8 31.4 9.9 5 9 14 186.8 5.6 5 11 21 164.9 4.7 5 5 3 368.2 5.5 5 7 9 690.3 8.9 5 9 15 786.5 10.1 5 11 22 105.0 7.0 5 5 4 154.0 2.6 5 7 10 114.2 3.6 5 9 16 189.4 4.0 5 11 23 153.0 4.1 5 5 5 380.0 5.2 5 7 11 549.2 8.1 5 9 17 282.8 4.8 5 11 24 113.7 5.0 5 5 6 140.4 2.7 5 7 12 161.2 3.3 5 9 18 108.0 4.6 5 11 25 91.8 6.8 5 5 7 122.9 3.3 5 7 13 154.9 3.2 5 9 19 142.4 4.0 5 11 26 290.4 5.6 5 5 8 428.4 6.2 5 7 14 273.5 5.1 5 9 20 275.6 4.4 5 11 27 423.1 14.1 5 5 9 204.1 3.2 5 7 15 594.3 8.3 5 9 21 190.4 3.8 5 11 28 144.9 5.7 5 5 10 408.1 5.7 5 7 16 424.9 5.9 5 9 22 424.2 6.6 5 11 29 122.3 6.7 5 5 11 223.3 3.8 5 7 17 304.1 4.9 5 9 23 102.8 4.8 5 11 30 217.6 6.7 5 5 12 388.9 5.5 5 7 18 215.4 4.5 5 9 24 82.6 6.8 5 11 31 43.2 15.7 5 5 13 574.4 8.8 5 7 19 233.0 4.8 5 9 25 178.8 4.3 5 12 0 372.1 7.6 5 5 14 390.6 5.7 5 7 20 225.7 3.8 5 9 26 94.6 5.7 5 12 1 293.8 5.7 5 5 15 500.7 7.4 5 7 21 97.0 7.4 5 9 28 93.2 7.2 5 12 2 271.5 3.7 5 5 16 404.2 6.3 5 7 22 387.2 5.6 5 9 29 132.1 7.9 5 12 3 173.6 2.7 5 5 17 140.0 6.3 5 7 23 324.7 4.9 5 9 30 109.9 10.2 5 12 4 85.3 3.5 WO 99/10379 PCT/GB98/02542 -124 5 12 5 260.8 3.6 5 14 14 404.7 6.4 5 16 23 90.1 6.1 5 19 3 309.9 4.3 5 12 6 409.0 6.1 5 14 15 82.9 5.6 5 16 24 38.5 11.1 5 19 4 48.7 5.8 5 12 7 572.7 8.0 5 14 16 353.1 5.1 5 16 25 36.8 14.5 5 19 5 136.9 3.5 5 12 8 380.4 5.2 5 14 17 150.5 3.6 5 16 26 94.7 9.6 5 19 6 390.9 6.5 5 12 9 42.2 7.9 5 14 18 344.7 5.1 5 16 27 138.8 6.3 5 19 7 51.6 6.8 5 12 10 497.4 7.3 5 14 19 84.4 5.8 5 16 28 71.2 9.6 5 19 8 461.0 6.0 5 12 11 211.1 3.6 5 14 20 172.5 3.8 5 16 29 45.1 15.3 5 19 9 157.1 3.3 5 12 12 247.5 3.8 5 14 21 100.8 5.1 5 16 30 96.0 14.4 5 19 10 338.9 5.5 5 12 13 491.9 7.3 5 14 22 125.1 5.4 5 17 0 299.7 4.6 5 19 11 183.2 3.4 5 12 14 301.9 4.6 5 14 23 257.3 4.3 5 17 1 686.1 19.9 5 19 12 115.1 3.1 5 12 15 437.1 6.3 5 14 24 140.3 5.1 5 17 2 194.4 3.6 5 19 13 154.6 3.1 5 12 16 484.3 7.1 5 14 25 86.3 6.7 5 17 3 52.6 4.4 5 19 14 150.4 3.4 5 12 17 235.3 4.0 5 14 26 346.3 8.7 5 17 4 184.3 2.8 5 19 15 264.4 4.0 5 12 18 208.9 3.8 5 14 27 26.9 12.9 5 17 5 581.3 8.2 5 19 16 148.4 4.1 5 12 19 248.6 4.2 5 14 28 115.6 6.7 5 17 6 544.6 8.0 5 19 17 35.9 11.4 5 12 20 207.2 3.7 5 14 29 195.3 6.3 5 17 7 576.9 10.1 5 19 18 188.9 3.7 5 12 21 35.2 12.0 5 14 30 83.3 12.2 5 17 8 232.8 3.5 5 19 19 164.7 4.0 5 12 22 147.6 4.3 5 14 31 67.6 17.3 5 17 9 402.1 7.1 5 19 20 189.6 3.8 5 12 23 152.9 4.7 5 15 0 169.0 2.9 5 17 10 475.4 6.9 5 19 21 289.4 4.3 5 12 24 100.6 6.8 5 15 1 279.0 3.9 5 17 11 485.7 6.7 5 19 22 63.6 8.3 5 12 25 159.1 4.6 5 15 2 327.5 4.1 5 17 12 292.3 4.4 5 19 23 55.2 10.4 5 12 26 175.7 5.9 5 15 3 454.8 6.8 5 17 13 313.1 4.9 5 19 24 253.1 16.8 5 12 27 75.1 19.8 5 15 4 572.8 9.4 5 17 14 160.3 3.3 5 19 25 105.1 6.3 5 12 28 71.8 13.0 5 15 5 637.9 7.9 5 17 15 392.7 6.4 5 19 26 150.5 5.0 5 12 29 154.3 5.5 5 15 6 64.9 4.5 5 17 16 517.2 7.1 5 19 27 190.1 4.4 5 12 30 18.6 9.4 5 15 7 138.8 2.7 5 17 17 133.2 4.3 5 19 28 69.8 11.5 5 12 31 29.9 13.7 5 15 8 546.1 8.5 5 17 18 187.5 3.7 5 19 29 72.1 13.2 5 13 0 383.5 7.7 5 15 9 296.6 5.9 5 17 19 241.7 4.0 5 20 0 652.5 11.2 5 13 1 310.9 5.6 5 15 10 478.5 6.7 5 17 20 135.2 3.9 5 20 1 182.8 4.6 5 13 2 258.2 3.8 5 15 11 400.7 7.7 5 17 21 72.7 6.1 5 20 2 213.7 3.7 5 13 3 526.9 6.2 5 15 12 222.4 3.9 5 17 22 46.0 12.5 5 20 3 605.6 9.4 5 13 4 201.7 3.1 5 15 13 327.5 5.3 5 17 23 158.3 4.3 5 20 4 615.0 17.0 5 13 5 488.8 6.7 5 15 14 434.2 6.6 5 17 24 162.8 4.8 5 20 5 725.2 9.6 5 13 6 478.4 7.0 5 15 15 166.8 3.6 5 17 25 427.2 12.9 5 20 6 101.5 3.5 5 13 7 511.7 7.4 5 15 16 237.1 4.1 5 17 26 117.8 7.9 5 20 7 133.7 3.4 5 13 8 688.4 9.1 5 15 17 275.0 4.4 5 17 27 90.3 9.1 5 20 8 401.4 5.5 5 13 9 469.3 6.3 5 15 18 218.9 4.3 5 17 28 52.7 12.2 5 20 9 57.3 5.3 5 13 10 236.9 3.8 5 15 19 163.5 3.7 5 17 29 73.2 9.5 5 20 10 297.7 5.6 5 13 11 363.1 6.2 5 15 20 129.1 4.2 5 17 30 137.0 8.7 5 20 11 460.1 6.9 5 13 12 173.2 5.3 5 15 21 61.9 8.4 5 18 0 609.2 9.8 5 20 12 334.6 4.6 5 13 13 322.4 4.6 5 15 22 117.5 5.4 5 18 1 345.0 7.0 5 20 13 236.0 3.6 5 13 14 80.0 6.7 5 15 23 57.1 8.6 5 18 2 546.7 9.0 5 20 14 66.9 5.9 5 13 15 493.3 7.7 5 15 24 169.5 4.4 5 18 3 419.4 5.8 5 20 15 100.1 4.0 5 13 16 213.4 3.8 5 15 25 231.5 4.7 5 18 4 88.4 7.4 5 20 16 57.6 7.6 5 13 17 257.1 4.8 5 15 26 185.4 10.1 5 18 5 381.6 7.0 5 20 17 148.7 3.4 5 13 18 287.2 4.9 5 15 27 176.5 6.3 5 18 6 315.2 4.2 5 20 18 219.3 3.8 5 13 19 116.1 4.5 5 15 28 47.4 16.2 5 18 7 445.6 7.7 5 20 19 91.2 4.4 5 13 20 69.9 6.9 5 15 29 52.8 15.6 5 18 8 86.9 8.4 5 20 20 152.5 4.1 5 13 21 263.1 4.0 5 15 30 94.6 9.2 5 18 9 133.1 3.2 5 20 21 65.1 8.4 5 13 22 166.1 3.6 5 16 0 239.5 4.8 5 18 10 721.6 10.8 5 20 22 150.8 3.7 5 13 23 99.0 5.8 5 16 1 754.2 20.6 5 18 11 257.1 3.8 5 20 23 19.9 9.8 5 1.3 24 64.3 8.6 5 16 2 231.4 3.1 5 18 12 218.6 3.9 5 20 25 226.3 4.8 5 13 25 149.1 4.6 5 16 3 307.9 3.9 5 18 13 226.9 3.6 5 20 26 39.4 14.4 5 13 26 34.3 15.6 5 16 4 358.1 5.0 5 18 14 325.1 5.2 5 20 27 165.6 5.5 5 13 27 120.4 6.7 5 16 5 399.1 6.6 5 18 15 370.7 5.7 5 20 28 98.3 6.7 5 13 28 168.2 5.6 5 16 6 734.9 8.4 5 18 16 195.4 4.4 5 21 0 731.5 13.6 5 13 29 135.9 6.7 5 16 7 275.2 4.0 5 18 17 41.0 9.7 5 21 1 482.1 10.1 5 13 30 33.6 14.7 5 16 8 334.9 7.0 5 18 18 193.8 4.3 5 21 2 259.5 5.3 5 13 31 46.6 15.3 5 16 9 110.8 3.6 5 18 19 316.2 5.6 5 21 3 250.2 4.1 5 14 0 437.5 7.7 5 16 10 391.0 6.8 5 18 20 117.7 4.5 5 21 4 292.2 4.0 5 14 1 482.7 8.5 5 16 11 384.8 6.5 5 18 21 273.7 4.3 5 21 5 629.1 9.8 5 14 2 472.6 6.7 5 16 12 130.7 3.9 5 18 22 72.1 8.7 5 21 6 145.7 3.0 5 14 3 872.3 12.1 5 16 13 356.1 5.2 5 18 23 67.3 7.9 5 21 7 416.8 6.0 5 14 4 483.7 7.3 5 16 14 359.9 5.6 5 18 24 22.0 10.8 5 21 8 396.8 6.0 5 14 5 318.4 5.0 5 16 15 144.2 4.3 5 18 25 165.7 5.1 5 21 9 252.4 3.8 5 14 6 687.5 9.1 5 16 16 163.0 4.2 5 18 26 204.2 4.6 5 21 10 549.6 7.9 5 14 7 374.6 4.7 5 16 17 272.5 4.3 5 18 27 96.8 10.5 5 21 11 313.2 4.7 5 14 8 240.3 3.8 5 16 18 211.5 3.8 5 18 28 101.8 10.3 5 21 12 295.2 4.7 5 14 9 138.8 2.8 5 16 19 192.6 3.6 5 18 29 18.1 9.0 5 21 13 61.7 5.9 5 14 10 438.4 6.5 5 16 20 75.6 6.4 5 19 0 221.8 5.8 5 21 14 102.5 3.5 5 14 12 464.2 6.1 5 16 21 167.3 3.9 5 19 1 341.1 7.1 5 21 15 304.8 4.5 5 14 13 293.1 4.6 5 16 22 153.9 4.4 5 19 2 326.9 5.7 5 21 16 174.2 3.3 WO 99/10379 PCT/GB98/02542 -125 5 21 17 107.0 3.8 5 24 3 286.9 4.8 5 26 21 139.1 4.6 5 29 16 113.9 6.4 5 21 18 244.1 3.8 5 24 4 158.7 2.7 5 26 22 90.6 6.5 5 29 17 168.0 6.9 5 21 19 83.3 5.6 5 24 5 271.6 3.8 5 26 23 93.1 5.8 5 29 18 13.5 6.8 5 21 20 147.0 3.8 5 24 6 275.6 4.5 5 26 24 106.9 5.7 5 29 19 92.0 6.5 5 21 21 167.5 3.8 5 24 7 213.5 3.5 5 26 25 149.0 6.1 5 29 20 55.7 7.9 5 21 22 152.1 4.9 5 24 8 334.2 5.0 5 27 0 298.9 5.8 5 29 21 149.4 4.6 5 21 23 447.8 15.8 5 24 9 260.4 3.7 5 27 1 247.6 4.2 5 29 22 176.7 5.5 5 21 24 126.5 7.3 5 24 10 324.3 4.4 5 27 2 255.8 4.4 5 29 23 66.7 10.0 5 21 25 217.2 4.6 5 24 11 120.5 3.1 5 27 3 226.0 4.7 5 30 0 124.3 3.2 5 21 26 135.7 6.0 5 24 12 236.4 4.2 5 27 4 105.2 2.6 5 30 1 253.6 4.5 5 21 27 151.3 6.9 5 24 13 132.3 3.0 5 27 5 371.0 4.8 5 30 2 132.6 2.7 5 21 28 199.8 5.7 5 24 14 209.8 3.3 5 27 6 103.5 2.4 5 30 3 197.8 3.6 5 22 0 108.1 3.5 5 24 15 25.2 9.5 5 27 7 13.1 6.3 5 30 4 130.6 2.8 5 22 1 485.8 9.1 5 24 16 92.4 4.1 5 27 8 18.8 8.2 5 30 5 315.0 4.9 5 22 2 334.1 7.0 5 24 17 134.3 3.5 5 27 9 50.7 5.4 5 30 6 318.2 4.2 5 22 3 220.1 4.1 5 24 18 150.4 3.5 5 27 10 213.8 3.4 5 30 7 158.4 2.6 5 22 4 521.7 7.2 5 24 19 149.6 4.1 5 27 11 93.7 3.2 5 30 8 84.7 3.0 5 22 5 255.0 3.7 5 24 20 143.0 4.9 5 27 12 137.6 2.9 5 30 9 113.6 2.9 5 22 6 579.1 8.1 5 24 21 392.8 17.1 5 27 13 157.6 3.1 5 30 10 364.9 5.5 5 22 7 158.0 3.1 5 24 22 120.0 5.7 5 27 14 57.9 5.6 5 30 11 183.4 3.0 5 22 8 186.8 3.0 5 24 23 77.6 10.4 5 27 15 51.8 7.7 5 30 12 83.3 3.9 5 22 9 390.7 5.3 5 24 24 51.5 11.5 5 27 16 202.7 3.5 5 30 13 127.5 3.2 5 22 10 64.4 4.7 5 24 25 38.9 14.1 5 27 17 137.1 3.7 5 30 14 75.5 5.3 5 22 11 113.1 3.4 5 24 26 59.5 14.7 5 27 18 272.6 4.5 5 30 15 31.5 14.8 5 22 12 347.0 5.0 5 25 0 312.9 6.4 5 27 19 85.0 11.2 5 30 16 15.6 7.8 5 22 13 437.4 6.5 5 25 1 109.9 3.5 5 27 20 28.4 11.8 5 30 17 122.1 3.8 5 22 14 195.0 3.4 5 25 2 170.9 3.7 5 27 21 68.2 6.6 5 30 18 71.8 6.2 5 22 15 305.9 4.1 5 25 3 311.6 5.6 5 27 22 37.9 11.4 5 30 19 72.6 7.3 5 22 16 111.8 3.7 5 25 4 250.6 3.2 5 27 23 115.4 7.6 5 30 20 187.3 4.1 5 22 17 45.2 11.2 5 25 5 379.1 5.7 5 27 24 116.2 6.8 5 30 21 29.7 12.6 5 22 18 109.5 3.9 5 25 6 113.6 3.3 5 27 25 61.0 11.8 5 30 22 46.8 11.0 5 22 19 142.3 3.8 5 25 7 388.1 6.6 5 28 0 256.6 6.0 5 31 0 82.0 3.1 5 22 20 221.3 4.3 5 25 8 262.5 4.0 5 28 1 63.8 3.5 5 31 1 227.6 3.9 5 22 21 88.4 5.8 5 25 9 189.2 3.2 5 28 2 172.1 3.5 5 31 2 161.8 4.5 5 22 22 165.2 10.1 5 25 10 218.6 3.4 5 28 3 40.5 6.1 5 31 3 215.9 4.0 5 22 23 55.8 10.6 5 25 11 136.8 3.0 5 28 4 245.1 3.6 5 31 4 119.1 3.5 5 22 24 65.6 9.9 5 25 12 263.1 4.3 5 28 5 124.6 2.4 5 31 5 364.2 5.5 5 22 25 180.0 4.9 5 25 13 267.2 4.0 5 28 6 123.6 2.6 5 31 6 238.2 3.6 5 22 26 122.9 5.7 5 25 14 156.7 3.5 5 28 7 180.7 3.0 5 31 7 262.6 3.8 5 22 27 112.4 10.2 5 25 15 59.6 5.7 5 28 8 256.3 3.8 5 31 8 175.3 3.1 5 22 28 159.9 10.0 5 25 16 119.8 3.6 5 28 9 157.1 3.0 5 31 9 62.8 4.8 5 23 0 313.0 6.7 5 25 17 297.3 4.4 5 28 10 295.4 4.2 5 31 10 58.0 4.3 5 23 1 336.3 7.0 5 25 18 162.8 3.4 5 28 11 165.5 4.1 5 31 11 126.8 3.4 5 23 2 220.4 4.5 5 25 19 150.1 3.8 5 28 12 249.5 3.8 5 31 12 114.1 3.4 5 23 3 419.9 6.4 5 25 20 172.6 15.3 5 28 13 75.5 5.3 5 31 13 159.9 5.4 5 23 4 289.5 4.1 5 25 21 265.1 4.5 5 28 14 132.0 3.7 5 31 14 312.6 9.3 5 23 5 119.2 2.7 5 25 22 99.7 8.2 5 28 15 16.7 7.9 5 31 15 205.3 4.2 5 23 6 237.5 3.4 5 25 23 36.5 13.7 5 28 16 169.3 3.4 5 31 16 90.2 5.0 5 23 7 274.8 4.4 5 25 24 180.4 4.9 5 28 17 66.5 8.1 5 31 17 132.1 4.3 5 23 8 171.7 3.0 5 25 25 146.1 5.3 5 28 18 187.1 8.3 5 31 18 211.7 3.8 5 23 9 221.4 3.3 5 25 26 115.6 7.6 5 28 19 179.6 4.3 5 31 19 53.6 8.5 5 23 10 128.3 3.1 5 26 0 374.6 7.4 5 28 20 166.9 3.7 5 31 20 79.8 7.1 5 23 11 252.6 4.0 5 26 1 264.1 5.7 5 28 21 126.0 4.6 5 32 0 93.1 3.1 5 23 12 442.9 6.1 5 26 2 244.5 4.7 5 28 22 183.5 4.5 5 32 1 201.7 3.8 5 23 13 123.3 3.1 5 26 3 250.6 5.2 5 28 23 240.7 5.8 5 32 2 219.1 4.2 5 23 14 69.5 5.9 5 26 4 77.9 3.7 5 28 24 22.7 10.9 5 32 3 188.5 3.5 5 23 15 184.0 3.6 5 26 5 423.3 5.4 5 29 0 40.2 4.8 5 32 4 124.2 3.2 5 23 16 151.0 3.3 5 26 6 76.0 4.1 5 29 1 101.3 5.3 5 32 5 121.9 2.6 5 23 17 93.9 5.0 5 26 7 332.5 4.9 5 29 2 171.1 3.7 5 32 6 159.7 2.7 5 23 18 72.4 6.6 5 26 8 335.7 5.3 5 29 3 227.7 4.4 5 32 7 153.3 2.6 5 23 19 15.9 7.9 5 26 9 395.6 6.0 5 29 4 135.9 2.7 5 32 8 61.8 4.3 5 23 20 146.4 4.1 5 26 10 192.7 4.3 5 29 5 74.7 3.1 5 32 9 162.1 3.1 5 23 21 20.4 10.0 5 26 11 137.1 3.0 5 29 6 154.7 2.5 5 32 10 100.8 3.1 5 23 22 199.6 6.1 5 26 12 15.8 7.3 5 29 7 261.8 3.6 5 32 11 154.0 3.4 5 23 23 149.7 5.0 5 26 13 252.0 4.3 5 29 8 124.5 2.7 5 32 12 106.1 6.6 5 23 24 349.7 5.3 5 26 14 23.5 9.4 5 29 9 66.1 3.8 5 32 13 214.0 11.2 5 23 25 90.7 10.1 5 26 15 206.7 3.8 5 29 10 59.6 5.0 5 32 14 182.2 3.9 5 23 26 58.1 13.8 5 26 16 117.5 3.6 5 29 11 113.3 3.0 5 32 15 157.6 3.6 5 23 27 207.6 4.8 5 26 17 114.5 3.8 5 29 12 84.4 4.2 5 32 16 47.9 9.4 5 24 0 271.4 6.1 5 26 18 191.1 3.7 5 29 13 67.5 4.0 5 32 17 155.6 3.9 5 24 1 91.0 3.7 5 26 19 21.4 10.4 5 29 14 62.5 5.7 5 32 18 54.7 8.0 5 24 2 303.4 5.2 5 26 20 22.8 10.5 5 29 15 120.4 4.0 5 32 19 123.1 4.1 WO 99/10379 PCT/GB98/02542 -126 5 32 20 111.8 4.8 5 36 13 164.0 3.5 6 0 23 61.8 17.0 6 2 29 95.8 8.5 5 32 21 49.8 13.1 5 36 14 59.4 6.8 6 0 24 231.8 9.5 6 2 30 62.5 17.0 5 33 0 227.4 4.2 5 36 15 50.4 8.3 6 0 25 42.0 19.5 6 2 31 184.7 7.1 5 33 1 68.6 3.1 5 36 16 55.9 8.8 6 0 26 90.7 8.2 6 2 32 84.5 10.2 5 33 2 157.7 3.6 5 37 0 227.0 8.0 6 0 27 93.3 8.6 6 3 0 100.0 2.6 5 33 3 155.6 3.1 5 37 1 194.4 6.5 6 0 28 196.5 19.1 6 3 1 129.3 2.7 5 33 4 156.0 3.2 5 37 2 86.7 4.2 6 0 29 60.4 20.2 6 3 2 218.0 3.4 5 33 5 13.5 6.5 5 37 3 136.4 5.3 6 0 30 85.8 16.1 6 3 3 436.8 5.8 5 33 6 165.6 3.2 5 37 4 33.7 7.3 6 0 31 28.1 18.1 6 3 4 166.5 2.9 5 33 7 76.9 4.2 5 37 5 150.1 3.4 6 0 32 26.6 18.0 6 3 5 517.3 9.0 5 33 8 98.5 2.9 5 37 6 103.9 3.9 6 1 0 456.4 6.3 6 3 6 129.2 3.1 5 33 9 90.9 3.3 5 37 7 80.3 4.0 6 1 1 284.4 4.0 6 3 7 147.5 3.4 5 33 10 18.1 8.6 5 37 8 190.4 3.0 6 1 2 336.2 4.6 6 3 8 229.7 3.5 5 33 11 259.0 7.9 5 37 9 141.5 2.7 6 1 3 228.1 3.5 6 3 9 235.8 4.1 5 33 12 140.9 4.2 5 37 10 82.6 3.8 6 1 4 201.2 3.1 6 3 10 89.5 5.8 5 33 13 316.6 4.3 5 37 11 139.6 3.2 6 1 5 262.4 4.4 6 3 11 301.9 5.3 5 33 14 132.1 3.6 5 37 12 154.5 3.4 6 1 6 179.3 2.7 6 3 12 572.8 8.1 5 33 15 125.0 3.6 5 37 13 228.1 4.0 6 1 7 192.6 3.7 6 3 13 120.0 4.0 5 33 16 101.9 5.1 5 37 14 170.2 3.7 6 1 8 345.0 4.4 6 3 14 478.6 6.4 5 33 17 80.1 6.9 5 37 15 60.3 10.9 6 1 9 115.8 2.8 6 3 15 405.6 11.0 5 33 18 58.0 9.0 5 38 2 165.6 5.3 6 1 10 377.2 6.1 6 3 16 357.9 5.3 5 33 19 57.0 8.2 5 38 4 160.3 3.3 6 1 11 181.8 3.4 6 3 17 243.8 4.7 5 33 20 81.6 10.6 5 38 5 108.2 3.1 6 1 12 252.7 4.0 6 3 18 330.9 5.4 5 34 0 151.6 4.6 5 38 6 268.2 5.4 6 1 13 142.3 3.3 6 3 19 169.0 4.0 5 34 1 169.1 3.2 5 38 7 163.6 3.7 6 1 14 218.7 5.1 6 3 20 294.5 4.9 5 34 2 131.7 2.9 5 38 8 86.2 3.1 6 1 15 275.5 8.4 6 3 21 141.1 4.1 5 34 3 25.8 8.4 5 38 9 114.4 2.8 6 1 16 349.9 5.5 6 3 22 257.2 4.3 5 34 4 162.1 3.2 5 38 10 149.8 3.2 6 1 17 244.4 4.7 6 3 23 178.6 4.5 5 34 5 44.3 6.0 5 38 11 121.4 3.3 6 1 18 244.9 4.2 6 3 24 128.5 4.8 5 34 6 186.4 3.1 5 38 12 86.7 4.1 6 1 19 258.1 4.6 6 3 25 49.6 13.0 5 34 7 175.2 3.0 5 38 13 62.2 7.1 6 1 20 129.2 5.9 6 3 26 79.2 7.3 5 34 8 219.8 5.5 5 39 1 82.5 4.1 6 1 21 120.1 5.3 6 3 27 73.1 7.9 5 34 9 237.4 7.2 5 39 2 148.1 5.1 6 1 22 168.4 4.1 6 3 28 34.8 15.6 5 34 10 69.2 7.3 5 39 3 154.6 5.4 6 1 23 105.2 7.2 6 3 29 102.7 7.3 5 34 11 48.9 6.1 5 39 4 166.3 5.7 6 1 24 45.6 11.9 6 3 30 301.1 5.7 5 34 12 33.0 10.9 5 39 5 88.7 6.2 6 1 25 77.1 8.4 6 3 31 109.4 8.9 5 34 13 120.2 4.1 5 39 6 28.0 11.6 6 1 26 72.4 9.1 6 3 32 34.5 15.4 5 34 14 165.9 3.8 5 39 7 84.1 2.9 6 1 27 112.6 5.5 6 4 0 40.7 4.4 5 34 15 80.3 5.7 5 39 8 117.8 3.0 6 1 28 136.5 18.7 6 4 1 124.6 2.5 5 34 16 232.1 4.0 5 39 9 66.6 4.2 6 1 29 143.2 5.7 6 4 2 67.3 3.4 5 34 17 16.6 8.1 5 39 10 60.7 4.7 6 1 30 183.6 5.8 6 4 3 491.9 8.6 5 34 18 194.3 6.0 5 39 11 203.2 4.6 6 1 31 76.0 11.3 6 4 4 247.5 4.0 5 35 0 42.9 7.1 5 40 2 20.0 8.6 6 1 32 224.6 5.8 6 4 5 295.0 4.3 5 35 1 95.7 4.4 5 40 5 224.1 5.2 6 2 0 334.4 4.8 6 4 6 429.5 5.5 5 35 2 172.3 5.0 5 40 6 213.8 4.7 6 2 1 275.0 3.9 6 4 7 144.7 3.3 5 35 3 202.8 3.9 5 40 7 80.1 4.1 6 2 2 284.0 3.9 6 4 8 619.6 9.5 5 35 4 51.3 5.9 5 40 8 60.8 4.6 6 2 3 75.3 3.0 6 4 9 294.3 4.5 5 35 5 149.2 4.9 5 40 9 17.3 8.1 6 2 4 402.6 6.7 6 4 10 646.6 10.0 5 35 6 199.1 6.5 5 41 4 119.3 4.7 6 2 5 231.2 3.3 6 4 11 408.1 6.2 5 35 7 146.7 7.1 5 41 5 139.1 5.0 6 2 6 446.1 6.9 6 4 12 422.1 5.7 5 35 8 45.9 5.8 6 0 0 102.9 3.6 6 2 7 252.9 3.6 6 4 13 183.3 4.8 5 35 9 287.4 4.1 6 0 1 194.6 4.4 6 2 8 317.3 4.6 6 4 14 501.6 7.4 5 35 10 113.6 3.2 6 0 2 210.0 4.2 6 2 9 461.7 6.7 6 4 15 624.7 9.2 5 35 11 113.3 4.5 6 0 3 430.1 9.3 6 2 10 440.8 6.4 6 4 16 520.6 7.8 5 35 12 241.0 4.3 6 0 4 471.7 14.4 6 2 11 331.9 5.1 6 4 17 244.8 4.4 5 35 13 67.3 6.9 6 0 5 123.2 3.9 6 2 12 320.6 4.7 6 4 18 257.6 5.3 5 35 14 167.0 3.8 6 0 6 58.9 7.8 6 2 13 101.3 4.2 6 4 19 287.1 4.5 5 35 15 91.5 4.8 6 0 7 431.0 9.0 6 2 14 290.7 5.9 6 4 20 362.1 5.5 5 35 16 68.3 8.5 6 0 8 74.9 6.5 6 2 15 482.8 7.5 6 4 21 130.0 5.4 5 35 17 62.6 6.1 6 0 9 532.0 11.1 6 2 16 915.0 13.4 6 4 22 251.1 4.5 5 36 1 189.1 10.1 6 0 10 491.7 10.4 6 2 17 157.8 4.8 6 4 23 26.8 11.3 5 36 2 385.8 9.9 6 0 11 361.2 8.0 6 2 18 138.6 5.2 6 4 24 207.4 4.3 5 36 3 253.3 7.7 6 0 12 15.8 11.0 6 2 19 234.9 4.2 6 4 25 147.2 4.8 5 36 4 17.3 7.9 6 0 13 201.8 5.4 6 2 20 149.0 5.5 6 4 26 143.5 4.3 5 36 5 260.0 4.9 6 0 14 84.5 20.7 6 2 21 229.5 4.4 6 4 27 76.6 8.9 5 36 6 161.8 3.9 6 0 15 197.1 11.9 6 2 22 79.3 6.2 6 4 28 111.1 7.6 5 36 7 183.0 3.4 6 0 17 507.6 12.8 6 2 23 213.6 4.2 6 4 29 47.6 13.5 5 36 8 105.0 3.3 6 0 18 66.6 22.5 6 2 24 30.0 11.8 6 4 30 177.0 5.5 5 36 9 133.4 3.0 6 0 19 250.3 6.1 6 2 25 88.2 7.8 6 4 31 87.9 9.7 5 36 10 108.0 3.8 6 0 20 235.0 6.6 6 2 26 132.9 5.6 6 4 32 33.8 15.1 5 36 11 130.2 3.7 6 0 21 451.4 8.7 6 2 27 39.4 13.1 6 5 0 93.9 2.6 5 36 12 93.0 4.0 6 0 22 70.8 9.4 6 2 28 35.4 14.8 6 5 1 191.1 3.2 WO 99/10379 PCT/GB98/02542 -127 6 5 2 195.9 2.9 6 7 9 319.9 4.8 6 9 16 245.2 4.9 6 11 24 246.0 4.3 6 5 3 264.5 4.2 6 7 10 169.2 3.2 6 9 17 239.7 3.9 6 11 25 157.9 5.2 6 5 4 321.7 4.7 6 7 11 285.8 4.2 6 9 18 448.1 7.1 6 11 26 142.0 9.1 6 5 5 219.8 3.3 6 7 12 494.0 7.0 6 9 19 257.5 4.8 6 11 27 146.6 7.7 6 5 6 341.7 4.5 6 7 13 216.7 4.3 6 9 20 328.5 5.4 6 11 28 217.4 4.9 6 5 7 330.5 4.8 6 7 14 653.1 10.0 6 9 21 68.2 7.1 6 11 29 189.0 5.4 6 5 8 117.9 3.3 6 7 15 513.8 7.2 6 9 22 195.9 4.0 6 11 30 77.5 10.5 6 5 9 497.4 6.9 6 7 16 189.1 4.1 6 9 23 325.0 5.2 6 11 31 164.9 6.5 6 5 10 235.4 4.0 6 7 17 140.1 4.5 6 9 24 31.1 12.1 6 12 0 596.3 11.5 6 5 11 680.9 10.7 6 7 18 264.6 4.6 6 9 25 153.9 4.5 6 12 1 124.0 2.9 6 5 12 347.9 4.9 6 7 19 127.5 4.0 6 9 26 93.6 7.4 6 12 2 202.9 3.2 6 5 13 211.7 4.9 6 7 20 69.2 8.9 6 9 27 142.1 14.9 6 12 3 508.0 7.4 6 5 14 199.8 4.0 6 7 21 146.5 4.4 6 9 28 53.6 11.9 6 12 4 222.1 3.4 6 5 15 620.5 9.8 6 7 22 150.7 4.5 6 9 29 88.5 10.9 6 12 5 362.0 5.4 6 5 16 339.3 5.7 6 7 23 49.1 15.3 6 9 30 36.5 15.4 6 12 6 165.6 3.0 6 5 17 208.7 4.6 6 7 24 25.3 11.2 6 9 31 32.3 14.7 6 12 7 563.1 9.1 6 5 18 276.9 4.3 6 7 25 131.5 5.6 6 10 0 54.0 4.3 6 12 8 129.9 3.0 6 5 19 117.4 6.4 6 7 26 103.6 6.5 6 10 1 156.9 3.1 6 12 9 383.8 5.5 6 5 20 263.7 4.5 6 7 27 190.2 13.8 6 10 2 362.2 5.3 6 12 10 580.8 10.0 6 5 21 86.3 6.0 6 7 28 78.5 9.5 6 10 3 113.7 3.4 6 12 11 64.7 8.1 6 5 22 44.1 10.8 6 7 29 143.4 7.1 6 10 4 149.2 3.2 6 12 12 433.2 7.2 6 5 23 171.4 4.5 6 7 30 166.4 6.7 6 10 5 322.8 4.7 6 12 13 275.5 4.8 6 5 24 66.6 8.7 6 7 31 114.2 12.9 6 10 6 917.1 12.1 6 12 14 90.3 6.2 6 5 25 192.8 5.6 6 7 32 90.6 12.3 6 10 7 769.7 10.2 6 12 15 237.7 5.4 6 5 26 114.4 5.5 6 8 0 94.8 2.3 6 10 8 62.5 5.9 6 12 16 102.6 5.2 6 5 27 150.2 6.1 6 8 1 110.8 3.3 6 10 9 245.4 3.5 6 12 17 68.2 8.8 6 5 28 96.3 7.9 6 8 2 336.1 5.2 6 10 10 87.4 3.9 6 12 18 250.8 4.3 6 5 29 169.6 5.0 6 8 3 251.7 3.6 6 10 11 312.4 4.5 6 12 19 315.1 4.7 6 5 30 162.8 6.1 6 8 4 177.0 2.9 6 10 12 190.9 3.9 6 12 20 28.5 11.5 6 5 31 76.7 14.0 6 8 5 123.1 2.6 6 10 13 268.4 8.6 6 12 21 197.1 4.7 6 5 32 181.2 5.8 6 8 6 227.4 3.7 6 10 14 63.2 8.2 6 12 22 64.5 7.7 6 6 0 251.6 3.9 6 8 7 477.5 7.2 6 10 15 527.9 7.8 6 12 23 110.7 5.6 6 6 1 460.7 8.3 6 8 8 187.9 3.1 6 10 16 247.4 4.8 6 12 24 362.2 6.2 6 6 2 100.9 2.6 6 8 9 399.9 6.0 6 10 17 123.0 5.0 6 12 25 123.8 5.8 6 6 3 137.2 2.6 6 8 10 364.3 5.3 6 10 18 293.4 4.6 6 12 26 280.5 9.4 6 6 4 211.3 3.1 6 8 11 281.4 4.5 6 10 19 167.4 4.0 6 12 27 112.7 6.9 6 6 5 185.2 3.2 6 8 12 285.8 5.1 6 10 20 251.5 4.2 6 12 28 162.2 6.8 6 6 6 340.1 4.8 6 8 13 592.0 8.7 6 10 21 203.5 4.1 6 12 29 170.0 10.1 6 6 7 85.7 3.0 6 8 14 314.7 5.3 6 10 22 236.6 4.4 6 12 30 108.2 8.8 6 6 8 244.0 3.6 6 8 15 63.0 7.8 6 10 23 61.3 7.4 6 12 31 320.4 7.7 6 6 9 19.6 8.3 6 8 16 679.4 9.6 6 10 24 119.9 5.6 6 13 0 797.0 13.4 6 6 10 470.1 7.1 6 8 17 200.3 4.0 6 10 25 69.2 7.3 6 13 1 577.5 11.5 6 6 11 632.3 9.9 6 8 18 130.0 4.2 6 10 26 32.4 13.1 6 13 2 222.0 3.2 6 6 12 246.9 3.8 6 8 19 434.7 7.4 6 10 27 23.0 11.4 6 13 3 489.6 6.5 6 6 13 290.9 5.2 6 8 20 168.4 4.3 6 10 28 156.6 4.9 6 13 4 347.1 4.6 6 6 14 40.1 15.0 6 8 21 132.8 4.4 6 10 29 105.4 7.4 6 13 5 327.8 4.7 6 6 15 525.6 8.3 6 8 22 244.4 5.2 6 10 30 243.4 5.6 6 13 6 198.8 3.5 6 6 16 198.7 4.9 6 8 23 161.6 4.6 6 10 31 55.5 16.2 6 13 7 684.3 11.0 6 6 17 145.0 5.1 6 8 24 38.4 13.1 6 11 0 354.4 5.3 6 13 8 172.7 3.1 6 6 18 24.4 11.6 6 8 25 117.1 5.7 6 11 1 467.5 8.4 6 13 9 149.4 5.2 6 6 19 524.1 8.5 6 8 26 20.2 9.8 6 11 2 250.3 3.8 6 13 10 527.8 6.4 6 6 20 142.0 5.1 6 8 27 270.9 8.8 6 11 3 448.3 6.2 6 13 11 415.9 14.7 6 6 21 352.8 5.2 6 8 28 90.9 7.1 6 11 4 53.1 4.5 6 13 12 187.6 3.9 6 6 22 144.0 4.7 6 8 29 256.8 4.7 6 11 5 301.5 4.0 6 13 13 138.6 3.9 6 6 23 125.9 5.6 6 8 30 143.7 6.6 6 11 6 383.9 5.6 6 13 14 558.4 9.0 6 6 24 240.9 4.4 6 8 31 184.2 6.2 6 11 7 270.0 3.8 6 13 15 255.6 4.9 6 6 25 23.1 10.8 6 9 0 280.4 4.0 6 11 8 364.0 4.9 6 13 16 267.9 4.3 6 6 26 181.4 4.2 6 9 1 270.1 4.6 6 11 9 444.4 6.1 6 13 17 168.2 3.6 6 6 28 53.9 15.0 6 9 2 339.6 4.6 6 11 10 575.4 8.6 6 13 18 138.5 3.9 6 6 29 369.9 6.1 6 9 3 214.6 3.6 6 11 11 473.2 7.3 6 13 19 298.8 5.0 6 6 30 125.7 7.3 6 9 4 371.8 5.5 6 11 12 25.1 12.3 6 13 20 323.9 5.0 6 6 31 183.4 5.4 6 9 5 28.1 8.5 6 11 13 563.4 8.6 6 13 21 68.7 7.1 6 6 32 48.9 16.2 6 9 6 317.7 4.7 6 11 14 139.6 4.4 6 13 22 115.3 4.8 6 7 0 138.9 3.9 6 9 7 345.6 4.4 6 11 15 486.3 8.0 6 13 23 48.6 11.2 6 7 1 264.7 4.4 6 9 8 319.4 4.8 6 11 16 365.6 5.2 6 13 24 289.2 4.5 6 7 2 206.2 3.2 6 9 9 426.3 5.7 6 11 17 209.2 4.7 6 13 25 15.8 8.0 6 7 3 85.6 3.1 6 9 10 389.6 4.6 6 11 18 176.3 4.0 6 13 26 120.1 20.0 6 7 4 225.7 3.1 6 9 11 647.5 9.3 6 11 19 221.0 4.6 6 13 27 96.3 10.0 6 7 5 294.4 4.4 6 9 12 263.0 5.1 6 11 20 317.5 5.1 6 13 28 25.3 11.9 6 7 6 372.6 5.7 6 9 13 250.9 5.7 6 11 21 59.4 7.8 6 13 29 92.7 11.0 6 7 7 487.7 6.4 6 9 14 618.1 8.1 6 11 22 217.7 4.0 6 13 30 118.0 7.9 6 7 8 234.1 3.5 6 9 15 287.2 5.0 6 11 23 181.1 4.2 6 14 0 535.9 8.3 WO 99/10379 PCT/GB98/02542 -128 6 14 1 232.1 4.1 6 16 11 423.5 6.1 6 18 25 172.2 6.1 6 21 9 301.2 4.5 6 14 2 588.0 8.0 6 16 12 452.4 6.6 6 18 26 147.5 4.6 6 21 10 333.6 4.9 6 14 3 696.4 10.3 6 16 13 356.2 4.9 6 18 27 159.4 5.1 6 21 11 142.2 3.3 6 14 4 431.8 8.1 6 16 14 375.8 5.5 6 18 28 121.5 10.3 6 21 12 182.2 3.4 6 14 5 381.2 4.8 6 16 15 370.5 5.9 6 18 29 57.5 13.7 6 21 13 185.2 3.6 6 14 6 287.2 4.5 6 16 16 252.9 4.1 6 19 0 435.7 8.1 6 21 14 48.2 7.4 6 14 7 274.8 4.1 6 16 17 216.5 3.9 6 19 1 139.8 4.5 6 21 15 208.6 3.9 6 14 8 224.1 4.9 6 16 18 124.4 4.1 6 19 2 112.4 8.2 6 21 16 83.0 4.4 6 14 9 214.3 5.8 6 16 19 262.2 4.3 6 19 3 404.6 12.1 6 21 17 133.8 3.8 6 14 10 636.9 13.6 6 16 20 83.2 5.4 6 19 4 648.5 9.5 6 21 18 86.8 5.9 6 14 11 586.3 7.8 6 16 21 38.5 11.6 6 19 5 467.8 6.4 6 21 19 60.5 12.8 6 14 12 384.4 6.4 6 16 22 199.0 4.1 6 19 6 666.5 11.9 6 21 20 114.5 4.5 6 14 13 490.0 6.9 6 16 23 165.3 3.9 6 19 7 273.8 5.4 6 21 21 99.6 4.8 6 14 14 440.0 6.7 6 16 24 35.4 13.3 6 19 8 219.9 3.8 6 21 22 113.4 22.0 6 14 15 155.4 4.5 6 16 25 80.7 8.7 6 19 9 560.4 8.1 6 21 23 293.2 4.8 6 14 16 275.1 4.1 6 16 26 42.5 14.6 6 19 10 532.7 7.6 6 21 24 84.2 7.2 6 14 17 286.9 4.7 6 16 27 95.1 8.5 6 19 11 234.1 3.9 6 21 25 156.0 6.7 6 14 18 315.6 5.1 6 16 28 103.0 7.2 6 19 12 198.4 3.6 6 21 26 105.1 7.3 6 14 19 224.0 4.4 6 16 29 79.1 9.8 6 19 13 374.0 5.3 6 21 27 80.5 11.8 6 14 20 201.1 4.1 6 17 0 389.9 7.0 6 19 14 256.5 4.1 6 22 0 364.6 7.2 6 14 21 96.2 6.2 6 17 1 421.6 7.1 6 19 15 84.7 5.1 6 22 1 421.5 7.4 6 14 22 221.4 4.0 6 17 2 363.1 7.9 6 19 16 124.7 3.6 6 22 2 169.7 4.4 6 14 23 149.1 5.5 6 17 3 65.9 7.3 6 19 17 114.0 3.4 6 22 3 512.3 7.5 6 14 24 105.7 6.0 6 17 4 244.9 5.2 6 19 18 278.5 4.6 6 22 4 323.7 4.4 6 14 25 135.3 6.0 6 17 5 326.7 5.1 6 19 19 163.3 3.8 6 22 5 102.3 3.3 6 14 26 15.5 7.9 6 17 6 252.4 4.1 6 19 20 165.6 3.7 6 22 6 260.2 3.7 6 14 27 40.6 14.4 6 17 7 481.1 15.6 6 19 21 124.3 5.6 6 22 7 77.5 3.7 6 14 28 166.3 5.7 6 17 8 72.2 5.0 6 19 22 154.7 4.3 6 22 8 191.8 4.2 6 14 29 55.0 14.6 6 17 9 262.6 5.6 6 19 23 47.7 19.5 6 22 9 89.1 4.0 6 14 30 117.0 9.5 6 17 10 403.3 6.2 6 19 24 64.3 13.0 6 22 10 76.6 4.2 6 15 0 237.0 3.7 6 17 11 282.1 4.6 6 19 25 137.5 4.5 6 22 11 170.8 3.3 6 15 1 582.0 10.8 6 17 12 85.1 4.2 6 19 26 23.4 11.0 6 22 12 198.2 3.5 6 15 2 240.5 3.7 6 17 13 323.3 5.3 6 19 27 159.0 5.3 6 22 13 100.2 3.8 6 15 3 227.9 3.4 6 17 14 241.1 4.6 6 19 28 180.6 5.4 6 22 14 170.3 3.3 6 15 41110.5 15.0 6 17 15 277.1 4.2 6 20 0 455.8 8.9 6 22 15 70.9 4.7 6 15 5 648.3 9.5 6 17 16 71.2 6.2 6 20 1 348.4 7.3 6 22 16 262.5 3.8 6 15 6 123.4 3.3 6 17 17 139.7 3.5 6 20 2 191.0 3.4 6 22 17 90.6 4.3 6 15 7 541.8 8.5 6 17 18 97.7 5.0 6 20 3 324.6 4.9 6 22 18 109.3 4.3 6 15 8 214.2 4.1 6 17 19 119.7 4.0 6 20 4 175.4 3.5 6 22 19 247.1 4.3 6 15 9 90.0 8.5 6 17 20 167.9 4.4 6 20 5 462.1 6.0 6 22 20 188.0 4.6 6 15 10 291.3 4.4 6 17 21 102.2 5.0 6 20 6 324.8 5.2 6 22 21 123.9 5.6 6 15 11 250.6 4.2 6 17 22 171.3 4.0 6 20 7 237.8 4.2 6 22 22 23.6 11.8 6 15 12 509.4 7.5 6 17 23 152.0 5.4 6 20 8 315.1 4.8 6 22 23 93.9 6.0 6 15 13 36.5 9.1 6 17 25 77.3 11.4 6 20 9 163.4 3.5 6 22 24 75.9 8.1 6 15 14 338.0 5.3 6 17 26 41.8 13.9 6 20 10 240.1 4.5 6 22 25 77.4 9.0 6 15 15 140.0 3.6 6 17 27 210.1 5.1 6 20 11 341.0 4.8 6 22 26 80.7 9.1 6 15 16 39.7 10.5 6 17 28 134.8 10.5 6 20 12 32.3 9.9 6 22 27 65.9 12.3 6 15 17 18.2 8.6 6 17 29 155.3 6.1 6 20 13 286.5 4.8 6 23 0 143.2 3.7 6 15 18 136.3 4.0 6 18 0 223.1 6.0 6 20 14 18.8 8.5 6 23 1 256.2 4.6 6 15 19 159.5 4.1 6 18 1 269.6 5.9 6 20 15 81.6 4.5 6 23 2 195.3 4.2 6 15 20 232.4 4.0 6 18 2 449.4 6.9 6 20 16 207.0 3.5 6 23 3 181.8 3.7 6 1-5 21 77.9 6.2 6 18 3 228.5 3.4 6 20 17 246.6 3.8 6 23 4 135.7 2.6 6 15 22 94.9 7.9 6 18 4 194.0 3.1 6 20 18 150.2 3.4 6 23 5 255.1 3.9 6 15 23 146.6 4.7 6 18 6 280.0 8.2 6 20 19 170.1 4.0 6 23 6 129.7 2.9 6 15 24 52.4 10.2 6 18 7 82.7 4.7 6 20 20 196.9 3.7 6 23 7 303.0 4.6 6 15 25 286.1 12.3 6 18 8 328.8 5.3 6 20 21 117.0 4.7 6 23 8 63.8 4.7 6 15 26 189.6 5.0 6 18 9 151.3 3.7 6 20 22 29.0 11.9 6 23 9 464.8 8.3 6 15 27 101.8 6.9 6 18 10 268.7 4.7 6 20 23 193.0 23.3 6 23 10 114.2 4.3 6 15 28 85.2 10.9 6 18 11 144.5 3.9 6 20 24 119.0 5.9 6 23 11 325.5 4.6 6 15 29 111.8 7.3 6 18 12 25.5 10.6 6 20 25 139.5 5.3 6 23 12 315.3 4.3 6 15 30 124.0 7.1 6 18 13 41.2 10.5 6 20 26 118.1 8.4 6 23 13 348.7 5.5 6 16 0 243.3 5.1 6 18 14 212.8 3.6 6 20 27 29.4 13.5 6 23 14 274.2 4.6 6 16 1 149.7 3.4 6 18 15 240.0 4.2 6 20 28 67.0 10.6 6 23 15 279.9 4.0 6 16 2 195.1 3.1 6 18 16 119.6 3.7 6 21 0 101.1 3.3 6 23 16 74.2 5.0 6 16 3 391.1 5.2 6 18 17 44.9 11.2 6 21 1 246.3 4.1 6 23 17 136.7 4.6 6 16 4 441.4 6.1 6 18 18 253.9 4.1 6 21 2 194.1 3.9 6 23 18 125.8 3.8 6 16 5 437.0 6.9 6 18 19 126.6 3.9 6 21 3 403.0 10.8 6 23 19 250.8 4.1 6 16 6 435.9 7.2 6 18 20 137.8 4.2 6 21 4 260.3 4.0 6 23 20 83.3 5.6 6 16 7 83.8 5.1 6 18 21 125.2 4.4 6 21 5 175.8 3.1 6 23 21 293.6 13.9 6 16 8 291.9 8.1 6 18 22 126.7 5.2 6 21 6 591.2 8.7 6 23 22 35.5 12.0 6 16 9 160.3 5.6 6 18 23 18.4 9.1 6 21 7 120.5 3.0 6 23 23 118.2 5.0 6 16 10 354.2 5.2 6 18 24 159.7 15.5 6 21 8 369.0 5.1 6 23 24 162.9 4.9 WO 99/10379 PCT/GB98/02542 -129 6 23 25 106.1 6.3 6 26 18 208.6 4.7 6 29 16 147.2 13.3 6 33 0 126.3 3.0 6 23 26 72.6 13.9 6 26 19 92.9 7.9 6 29 17 146.1 3.5 6 33 1 73.7 4.1 6 24 0 255.5 4.8 6 26 20 39.6 11.3 6 29 18 60.4 7.6 6 33 2 223.3 4.4 6 24 1 355.3 6.6 6 26 21 14.1 7.1 6 29 19 150.8 3.7 6 33 3 251.6 4.9 6 24 2 247.0 4.3 6 26 22 21.1 10.1 6 29 20 142.6 4.0 6 33 4 243.5 4.8 6 24 3 274.9 5.9 6 26 23 135.3 7.3 6 29 21 111.1 5.9 6 33 5 122.6 3.4 6 24 4 353.9 4.7 6 26 24 54.8 12.8 6 29 22 130.9 4.4 6 33 6 143.5 2.9 6 24 5 145.6 2.9 6 26 25 26.3 12.6 6 30 0 192.6 4.0 6 33 7 156.0 3.0 6 24 6 326.9 4.5 6 27 0 380.2 6.5 6 30 1 67.8 4.2 6 33 8 13.5 6.6 6 24 7 172.1 3.4 6 27 1 593.7 10.9 6 30 2 221.6 3.8 6 33 9 94.3 11.7 6 24 8 415.4 6.6 6 27 2 156.9 3.6 6 30 3 292.1 5.3 6 33 10 118.3 11.6 6 24 9 157.2 2.9 6 27 3 269.7 5.5 6 30 4 91.1 3.5 6 33 11 143.2 3.3 6 24 10 87.6 5.9 6 27 4 257.5 4.3 6 30 5 280.9 4.7 6 33 12 30.2 10.6 6 24 11 29.1 10.0 6 27 5 263.0 3.8 6 30 6 115.7 3.1 6 33 13 167.5 3.4 6 24 12 54.8 6.5 6 27 6 163.9 2.9 6 30 7 136.4 2.6 6 33 14 164.8 4.1 6 24 13 58.7 5.6 6 27 7 48.5 5.3 6 30 8 54.5 5.0 6 33 15 218.1 3.5 6 24 14 172.7 3.9 6 27 8 190.0 2.7 6 30 9 159.2 3.2 6 33 16 16.5 8.0 6 24 15 287.8 4.6 6 27 9 107.2 3.9 6 30 10 171.1 2.9 6 33 17 295.0 4.6 6 24 16 235.6 4.0 6 27 10 271.1 4.1 6 30 11 225.4 3.6 6 33 18 99.2 9.2 6 24 17 180.1 3.4 6 27 11 117.4 3.3 6 30 12 80.2 3.9 6 33 19 29.6 12.5 6 24 18 231.3 3.9 6 27 12 233.1 3.6 6 30 13 75.9 4.6 6 34 0 354.7 6.2 6 24 19 71.9 6.1 6 27 13 131.1 3.4 6 30 14 161.9 8.4 6 34 1 254.4 4.7 6 24 20 214.7 15.3 6 27 14 102.5 4.8 6 30 16 156.8 3.6 6 34 2 275.0 5.8 6 24 21 17.3 8.5 6 27 15 93.5 4.0 6 30 17 103.3 4.4 6 34 3 112.0 3.4 6 24 22 82.9 7.7 6 27 16 67.1 7.6 6 30 18 231.4 4.6 6 34 4 243.3 4.4 6 24 23 173.1 4.8 6 27 17 188.6 4.2 6 30 19 95.6 5.6 6 34 5 110.8 4.3 6 24 24 217.6 4.8 6 27 18 272.0 9.5 6 30 20 81.5 6.7 6 34 6 87.6 7.1 6 24 25 99.1 7.2 6 27 19 136.9 4.5 6 30 21 82.2 7.4 6 34 7 279.9 8.2 6 24 26 23.3 10.9 6 27 20 137.5 4.6 6 30 22 18.7 9.4 6 34 8 71.3 9.5 6 25 0 134.1 4.5 6 27 21 163.2 4.6 6 31 0 242.3 4.8 6 34 9 239.4 4.3 6 25 1 56.3 7.4 6 27 22 58.2 11.9 6 31 1 174.8 3.5 6 34 10 56.0 6.6 6 25 2 278.2 7.4 6 27 23 40.9 12.6 6 31 2 78.3 4.1 6 34 11 65.0 4.8 6 25 3 229.6 5.4 6 27 24 41.1 14.7 6 31 3 200.7 4.0 6 34 12 41.0 9.2 6 25 4 373.6 6.0 6 28 0 321.8 5.7 6 31 4 237.9 4.9 6 34 13 87.4 4.8 6 25 5 332.8 4.5 6 28 1 62.3 4.5 6 31 5 214.8 3.8 6 34 14 128.6 3.6 6 25 6 279.1 4.1 6 28 2 82.4 3.7 6 31 6 93.3 2.9 6 34 15 93.9 5.2 6 25 7 108.1 3.3 6 28 3 93.4 3.4 6 31 7 136.6 2.7 6 34 16 273.0 4.8 6 25 8 134.3 2.7 6 28 4 141.4 3.2 6 31 8 106.0 3.2 6 34 17 100.9 4.5 6 25 9 109.0 3.2 6 28 5 234.0 3.7 6 31 9 207.2 3.7 6 34 18 135.3 5.6 6 25 10 264.2 3.9 6 28 6 158.1 2.7 6 31 10 116.2 3.8 6 35 0 146.3 3.4 6 25 11 206.7 3.4 6 28 7 161.0 2.8 6 31 11 81.2 5.0 6 35 2 98.0 8.8 6 25 12 379.7 5.7 6 28 8 218.9 3.4 6 31 12 79.0 5.9 6 35 3 290.6 11.6 6 25 13 338.9 5.4 6 28 9 112.4 3.2 6 31 13 269.6 12.4 6 35 4 249.6 7.8 6 25 14 92.1 4.5 6 28 10 83.4 3.8 6 31 14 150.4 3.8 6 35 5 128.8 5.0 6 25 15 104.9 3.7 6 28 11 130.2 3.5 6 31 15 193.8 3.5 6 35 6 113.2 3.4 6 25 16 115.6 4.6 6 28 12 208.7 3.6 6 31 16 94.1 5.1 6 35 7 39.8 8.1 6 25 17 101.9 5.6 6 28 13 135.1 3.5 6 31 17 154.6 4.0 6 35 8 189.0 3.5 6 25 18 43.7 10.8 6 28 14 121.4 3.3 6 31 18 233.5 4.2 6 35 9 185.4 3.3 6 25 20 110.3 6.3 6 28 15 188.7 3.5 6 31 19 36.9 10.5 6 35 10 320.9 5.3 6 25 21 132.1 4.4 6 28 16 85.4 5.0 6 31 20 72.8 6.5 6 35 11 151.3 3.9 6 25 22 72.7 6.4 6 28 17 155.5 17.2 6 31 21 47.6 14.1 6 35 12 133.1 3.8 6 25 23 266.0 5.9 6 28 18 99.1 5.0 6 32 0 252.4 5.3 6 35 13 91.6 5.0 6 25 24 55.8 14.1 6 28 19 102.9 4.9 6 32 1 60.2 4.5 6 35 14 64.3 5.6 6 25 25 75.2 8.0 6 28 20 51.6 9.6 6 32 2 144.0 3.0 6 35 15 103.3 4.4 6 26 0 126.6 3.2 6 28 21 154.1 4.5 6 32 3 129.3 3.1 6 35 16 132.5 4.5 6 26 1 526.5 12.4 6 28 22 196.7 4.5 6 32 4 105.7 3.2 6 36 0 14.4 6.8 6 26 2 41.8 8.8 6 28 23 49.7 14.9 6 32 5 53.8 6.1 6 36 1 180.7 3.5 6 26 3 75.8 6.3 6 29 0 69.7 3.8 6 32 6 46.9 5.9 6 36 2 96.4 3.5 6 26 4 161.8 3.1 6 29 1 171.3 3.7 6 32 7 142.9 2.9 6 36 3 142.8 3.8 6 26 5 253.7 3.6 6 29 2 186.4 3.9 6 32 8 191.0 3.2 6 36 4 97.1 3.9 6 26 6 229.3 3.5 6 29 3 306.7 6.0 6 32 9 139.9 3.0 6 36 5 112.3 3.1 6 26 7 329.2 4.5 6 29 4 491.6 9.0 6 32 10 178.0 3.0 6 36 6 76.3 4.5 6 26 8 413.5 5.2 6 29 5 203.6 3.1 6 32 11 92.9 9.7 6 36 7 290.9 4.8 6 26 9 162.0 3.0 6 29 6 103.2 2.7 6 32 12 136.9 8.4 6 36 8 177.6 3.0 6 26 10 334.8 4.9 6 29 7 196.9 2.9 6 32 13 174.9 3.7 6 36 9 17.5 7.9 6 26 11 212.9 3.3 6 29 8 185.1 2.8 6 32 14 62.7 6.7 6 36 10 138.5 3.0 6 26 12 17.9 8.4 6 29 9 139.6 3.0 6 32 15 195.7 4.5 6 36 11 109.7 3.7 6 26 13 337.8 5.3 6 29 10 284.5 4.6 6 32 16 38.7 10.5 6 36 12 17.2 8.5 6 26 14 53.8 6.2 6 29 11 154.7 3.5 6 32 17 169.6 4.6 6 36 13 202.8 3.8 6 26 15 181.0 3.5 6 29 12 170.5 3.1 6 32 18 82.5 5.3 6 36 14 179.5 4.3 6 26 16 67.6 6.2 6 29 13 108.4 3.3 6 32 19 112.8 4.8 6 36 15 60.6 9.4 6 26 17 104.6 5.1 6 29 14 57.2 6.9 6 32 20 85.0 8.9 6 37 0 18.4 7.7 WO 99/10379 PCT/GB98/02542 -130 6 37 1 89.4 4.4 7 0 24 18.2 13.0 7 3 0 153.5 4.0 7 5 8 562.4 8.9 6 37 2 140.1 3.5 7 0 25 125.7 6.6 7 3 1 115.3 3.2 7 5 9 231.5 3.9 6 37 3 184.5 3.9 7 0 26 48.9 20.1 7 3 2 194.2 3.1 7 5 10 194.8 3.6 6 37 4 312.9 6.4 7 0 27 325.1 12.4 7 3 3 273.9 4.2 7 5 11 265.4 4.3 6 37 5 193.3 4.3 7 0 28 29.4 18.6 7 3 4 281.8 4.0 7 5 12 271.8 5.5 6 37 6 199.4 3.9 7 0 29 25.2 17.5 7 3 5 365.5 5.5 7 5 13 387.5 8.9 6 37 7 14.9 7.2 7 0 30 29.6 18.6 7 3 6 625.9 8.6 7 5 14 282.0 4.6 6 37 8 102.0 3.5 7 0 31 97.7 12.1 7 3 7 536.2 8.5 7 5 15 355.7 5.5 6 37 9 86.7 4.1 7 1 0 278.2 4.4 7 3 8 480.8 6.3 7 5 16 146.6 4.8 6 37 10 134.0 3.2 7 1 1 448.7 7.0 7 3 9 185.7 4.0 7 5 17 196.1 4.1 6 37 11 77.0 4.7 7 1 2 243.2 3.2 7 3 10 203.8 3.6 7 5 18 297.2 4.8 6 37 12 86.1 6.4 7 1 3 245.9 4.1 7 3 11 372.2 5.6 7 5 19 214.1 4.2 6 37 13 88.6 4.8 7 1 4 272.2 4.0 7 3 12 356.3 5.9 7 5 20 351.5 5.4 6 37 14 107.1 5.9 7 1 5 366.2 4.6 7 3 13 502.2 6.8 7 5 21 105.4 5.7 6 38 0 143.7 5.2 7 1 6 301.1 4.2 7 3 14 213.7 6.2 7 5 22 137.5 4.7 6 38 1 45.1 7.5 7 1 7 151.2 3.1 7 3 15 333.4 5.5 7 5 23 62.6 9.0 6 38 2 157.6 3.0 7 1 8 181.1 3.3 7 3 16 406.5 6.4 7 5 24 106.8 5.4 6 38 3 158.6 4.0 7 1 9 158.4 3.4 7 3 17 218.8 4.9 7 5 25 114.2 5.8 6 38 4 240.9 5.1 7 1 10 250.8 3.9 7 3 18 188.1 5.9 7 5 26 33.9 13.2 6 38 5 193.2 4.8 7 1 11 22.0 9.8 7 3 19 270.4 4.6 7 5 27 167.7 11.0 6 38 6 156.2 4.0 7 1 12 496.2 7.0 7 3 20 91.3 6.5 7 5 28 198.1 5.4 6 38 7 160.1 3.5 7 1 13 402.0 5.3 7 3 21 91.1 5.4 7 5 29 148.7 7.1 6 38 8 88.1 3.8 7 1 14 351.5 12.1 7 3 22 64.1 11.7 7 5 30 146.2 7.3 6 38 9 154.9 2.9 7 1 15 342.6 5.5 7 3 23 79.1 6.6 7 5 31 121.9 7.0 6 38 10 69.0 4.8 7 1 16 226.2 4.7 7 3 24 106.7 6.0 7 6 0 142.9 4.1 6 38 11 77.7 4.7 7 1 17 21.5 10.1 7 3 25 142.5 6.4 7 6 1 233.8 5.0 6 38 12 98.0 5.3 7 1 18 200.4 6.4 7 3 26 118.6 6.7 7 6 2 341.7 5.8 6 39 0 109.1 4.5 7 1 19 252.5 5.3 7 3 27 299.9 12.3 7 6 3 120.9 2.8 6 39 1 83.3 6.2 7 1 20 141.0 4.6 7 3 28 22.6 11.4 7 6 4 95.6 3.1 6 39 2 75.7 5.0 7 1 21 103.2 5.2 7 3 29 176.6 6.5 7 6 5 498.8 6.5 6 39 3 173.7 7.9 7 1 22 64.1 15.4 7 3 30 120.7 7.8 7 6 6 501.4 7.0 6 39 4 147.4 3.8 7 1 23 132.9 4.7 7 3 31 88.8 9.5 7 6 7 222.8 3.8 6 39 5 94.1 4.4 7 1 24 168.1 4.6 7 4 0 335.0 4.7 7 6 8 139.3 3.0 6 39 6 127.1 3.8 7 1 25 87.5 6.4 7 4 1 451.7 8.9 7 6 9 265.3 3.9 6 39 7 94.2 4.3 7 1 26 164.0 5.8 7 4 2 366.5 4.7 7 6 10 375.7 5.2 6 39 8 80.9 3.5 7 1 27 416.0 8.4 7 4 3 339.9 4.8 7 6 11 248.3 3.9 6 39 9 43.1 6.6 7 1 28 100.7 9.5 7 4 4 248.5 4.0 7 6 12 286.8 5.0 6 39 10 47.4 10.4 7 1 29 193.9 5.9 7 4 5 61.2 4.7 7 6 13 361.1 12.2 6 40 0 102.7 4.7 7 1 30 133.4 8.6 7 4 6 439.1 5.9 7 6 14 179.5 4.0 6 40 1 134.2 4.6 7 1 31 34.0 14.2 7 4 7 369.6 5.9 7 6 15 240.0 5.2 6 40 2 87.7 6.2 7 2 0 261.3 5.3 7 4 8 279.2 4.9 7 6 16 183.2 6.2 6 40 3 50.4 5.3 7 2 1 153.3 3.1 7 4 9 98.5 4.3 7 6 17 258.3 4.5 6 40 4 104.5 3.6 7 2 2 214.7 3.3 7 4 10 113.5 3.7 7 6 18 252.7 4.5 6 40 5 99.8 3.8 7 2 3 334.2 4.8 7 4 11 390.4 5.9 7 6 19 36.9 14.9 6 40 6 149.9 4.1 7 2 4 273.5 4.7 7 4 12 198.9 7.6 7 6 20 96.9 7.2 6 40 7 123.8 5.9 7 2 5 312.8 4.5 7 4 13 468.0 6.7 7 6 21 190.1 4.2 6 41 0 167.3 5.7 7 2 6 292.2 4.3 7 4 14 247.8 6.2 7 6 22 73.5 9.0 6 41 1 82.7 13.2 7 2 7 174.7 3.2 7 4 15 226.1 4.7 7 6 23 140.8 6.0 7 0 0 39.6 15.5 7 2 8 315.9 4.9 7 4 16 560.8 8.3 7 6 24 128.3 6.2 7 0 1 454.8 8.1 7 2 9 220.0 3.5 7 4 17 178.6 6.1 7 6 25 108.4 5.7 7 0 2 280.3 5.0 7 2 10 410.6 5.6 7 4 18 68.0 8.1 7 6 26 116.3 9.9 7 0 3 67.1 5.4 7 2 11 22.7 9.9 7 4 19 150.5 4.7 7 6 27 29.0 14.0 7 0 4 10.5 7.6 7 2 12 335.7 5.5 7 4 20 75.1 7.8 7 6 28 45.3 16.1 7 0 5 50.6 11.0 7 2 13 107.0 6.0 7 4 21 349.9 5.4 7 6 29 96.8 8.8 7 0 6 120.5 4.8 7 2 14 167.6 11.0 7 4 22 154.4 5.1 7 6 30 126.2 7.0 7 0 7 539.2 10.2 7 2 15 130.8 4.5 7 4 23 70.6 7.3 7 6 31 70.4 11.4 7 0 8 506.3 10.9 7 2 16 428.0 6.9 7 4 24 19.5 9.4 7 7 0 440.5 6.6 7 0 9 95.9 6.1 7 2 17 25.9 11.3 7 4 25 130.7 5.6 7 7 1 289.5 5.0 7 0 10 86.4 10.0 7 2 18 287.0 4.7 7 4 26 94.2 8.1 7 7 2 177.9 3.0 7 0 11 294.7 6.1 7 2 19 157.1 4.1 7 4 27 257.8 14.0 7 7 3 113.9 2.9 7 0 12 263.8 6.3 7 2 20 92.7 6.6 7 4 28 38.7 16.6 7 7 4 357.2 7.5 7 0 13 26.2 18.0 7 2 21 233.0 4.3 7 4 29 250.7 5.4 7 7 5 527.9 7.3 7 0 14 427.1 11.7 7 2 22 247.9 4.1 7 4 30 173.1 6.9 7 7 6 272.3 5.0 7 0 15 19.1 13.4 7 2 23 26.2 11.1 7 4 31 33.6 15.2 7 7 7 286.7 4.1 7 0 16 316.5 7.3 7 2 24 169.8 5.0 7 5 0 407.9 6.2 7 7 8 304.6 4.3 7 0 17 228.2 9.1 7 2 25 30.3 11.9 7 5 1 224.0 3.8 7 7 9 576.7 8.0 7 0 18 352.6 8.6 7 2 26 137.8 6.5 7 5 2 245.2 3.5 7 7 10 384.6 5.8 7 0 19 43.8 19.3 7 2 27 413.6 8.3 7 5 3 268.7 3.6 7 7 11 350.5 5.7 7 0 20 158.3 6.0 7 2 28 174.4 7.0 7 5 4 258.3 3.7 7 7 12 547.5 7.8 7 0 21 139.9 6.1 7 2 29 115.3 8.8 7 5 5 165.3 3.0 7 7 13 301.8 7.1 7 0 22 35.3 21.0 7 2 30 202.9 5.5 7 5 6 488.3 6.2 7 7 14 304.4 5.1 7 0 23 73.3 11.5 7 2 31 67.2 13.5 7 5 7 274.9 4.5 7 7 15 439.3 6.2 WO 99/10379 PCT/GB98/02542 -131 7 7 16 301.5 5.1 7 9 25 170.7 5.3 7 12 4 132.7 3.0 7 14 15 158.9 3.6 7 7 17 339.6 5.3 7 9 26 326.1 11.5 7 12 5 70.5 4.3 7 14 16 178.7 4.1 7 7 18 413.5 6.6 7 9 27 53.2 15.3 7 12 6 304.1 4.9 7 14 17 449.7 7.1 7 7 19 43.6 11.6 7 9 28 178.1 5.3 7 12 7 233.6 3.7 7 14 18 225.5 3.9 7 7 20 171.3 4.1 7 9 29 214.7 6.4 7 12 8 375.8 5.8 7 14 19 280.4 4.6 7 7 21 93.8 5.2 7 9 30 202.6 6.9 7 12 9 55.6 7.3 7 14 20 80.8 6.4 7 7 22 145.6 4.5 7 9 31 50.9 15.1 7 12 10 1008.3 31.7 7 14 21 263.0 5.3 7 7 23 21.7 10.2 7 10 0 209.6 3.1 7 12 11 416.2 5.9 7 14 22 182.0 4.2 7 7 24 138.2 4.5 7 10 1 225.0 3.9 7 12 12 53.7 7.4 7 14 23 155.0 5.0 7 7 25 210.3 4.3 7 10 2 180.7 3.5 7 12 13 189.1 3.8 7 14 24 17.9 9.0 7 7 26 24.1 11.5 7 10 3 609.6 8.3 7 12 14 298.7 4.6 7 14 25 55.5 20.5 7 7 27 127.5 7.6 7 10 4 567.0 7.9 7 12 15 81.9 6.8 7 14 26 213.0 6.0 7 7 28 100.9 9.6 7 10 5 209.6 3.1 7 12 16 190.8 3.8 7 14 27 25.5 11.9 7 7 29 107.7 7.6 7 10 6 252.1 3.5 7 12 17 264.3 4.6 7 14 28 28.1 12.8 7 7 30 102.5 9.1 7 10 7 421.0 6.3 7 12 18 110.2 5.5 7 14 29 135.3 7.1 7 7 31 59.7 15.1 7 10 8 89.3 4.6 7 12 19 98.2 6.0 7 15 0 113.1 4.0 7 8 0 285.7 4.2 7 10 9 226.6 3.9 7 12 20 34.5 12.3 7 15 1 550.3 8.6 7 8 1 634.0 12.7 7 10 10 265.5 5.7 7 12 21 21.2 9.8 7 15 2 154.6 2.9 7 8 2 252.9 3.8 7 10 11 183.3 4.8 7 12 22 152.3 4.9 7 15 3 329.2 5.0 7 8 3 188.1 2.9 7 10 12 412.5 6.1 7 12 23 259.7 4.6 7 15 4 420.2 6.6 7 8 4 528.8 7.0 7 10 13 207.6 3.9 7 12 24 136.4 5.0 7 15 5 624.0 10.2 7 8 5 357.2 4.8 7 10 14 186.7 4.3 7 12 25 153.9 6.2 7 15 6 481.2 6.3 7 8 6 277.0 4.2 7 10 15 216.7 4.1 7 12 26 176.8 5.0 7 15 7 267.9 6.3 7 8 7 331.0 4.4 7 10 16 89.4 5.5 7 12 27 236.7 4.7 7 15 8 131.8 17.9 7 8 8 411.1 5.9 7 10 17 89.0 6.3 7 12 28 24.9 12.2 7 15 9 357.1 5.1 7 8 9 555.7 7.2 7 10 18 118.6 5.6 7 12 29 104.5 8.5 7 15 10 509.3 6.8 7 8 10 592.2 7.8 7 10 19 170.4 3.9 7 12 30 38.2 15.1 7 15 11 158.4 5.1 7 8 11 343.7 6.3 7 10 20 183.4 4.7 7 13 0 635.4 10.6 7 15 12 381.0 5.9 7 8 12 314.3 5.3 7 10 21 36.5 12.0 7 13 1 326.0 4.8 7 15 13 145.8 3.7 7 8 13 116.3 4.4 7 10 22 100.8 6.0 7 13 2 419.4 6.1 7 15 14 136.0 3.8 7 8 14 283.0 4.6 7 10 23 182.1 6.0 7 13 3 935.3 11.5 7 15 15 263.2 4.4 7 8 15 328.8 5.6 7 10 24 82.4 7.6 7 13 4 369.2 6.6 7 15 16 232.0 4.1 7 8 16 250.2 4.5 7 10 25 30.7 13.0 7 13 5 201.4 3.0 7 15 17 124.0 5.3 7 8 17 148.8 3.9 7 10 26 384.7 13.4 7 13 6 261.1 4.0 7 15 18 106.7 4.6 7 8 18 230.0 4.0 7 10 27 99.9 11.3 7 13 7 287.0 6.6 7 15 19 155.8 5.9 7 8 19 305.9 5.3 7 10 28 133.3 6.3 7 13 8 142.7 3.7 7 15 20 172.5 3.8 7 8 20 76.0 9.9 7 10 29 134.5 7.1 7 13 9 299.9 5.5 7 15 21 73.5 7.6 7 8 21 155.1 4.6 7 10 30 74.3 15.3 7 13 10 398.9 6.7 7 15 22 135.7 4.7 7 8 22 55.7 13.8 7 11 0 518.2 7.0 7 13 11 163.1 3.6 7 15 23 146.1 6.0 7 8 23 200.0 4.3 7 11 1 353.8 6.2 7 13 12 198.7 4.0 7 15 24 44.8 17.9 7 8 24 164.9 4.6 7 11 2 101.2 3.0 7 13 13 121.4 4.1 7 15 25 120.7 8.9 7 8 25 90.7 6.2 7 11 3 681.1 9.5 7 13 14 187.2 4.0 7 15 26 211.9 5.4 7 8 26 105.3 15.5 7 11 4 598.5 9.0 7 13 15 40.0 12.4 7 15 27 135.9 5.4 7 8 27 25.3 12.1 7 11 5 225.0 3.8 7 13 16 318.5 5.1 7 15 28 109.2 7.4 7 8 28 123.5 7.8 7 11 6 250.7 3.8 7 13 17 298.4 4.4 7 15 29 72.7 10.1 7 8 29 55.6 18.4 7 11 7 902.1 11.5 7 13 18 120.0 4.1 7 16 0 458.6 7.6 7 8 30 38.3 16.2 7 11 8 314.6 4.7 7 13 19 144.2 3.8 7 16 1 127.8 3.8 7 8 31 157.5 5.8 7 11 9 198.7 7.0 7 13 20 122.1 4.5 7 16 2 244.1 4.4 7 9 0 159.7 3.1 7 11 10 493.0 6.7 7 13 21 307.2 4.8 7 16 3 202.5 8.3 7 9 1 317.4 5.3 7 11 11 601.1 14.3 7 13 22 64.6 8.0 7 16 4 570.1 7.5 7 9 2 99.9 3.6 7 11 12 304.5 4.3 7 13 23 203.9 4.5 7 16 5 432.4 6.8 7 9 3 263.0 4.2 7 11 13 60.9 7.9 7 13 25 462.1 12.1 7 16 7 337.5 5.0 7 9 4 62.1 4.7 7 11 14 236.8 4.3 7 13 26 51.2 13.3 7 16 8 97.0 4.2 7 9 6 438.6 6.6 7 11 15 313.0 5.3 7 13 27 31.2 13.7 7 16 9 434.9 6.6 7 9 7 545.5 7.6 7 11 16 122.3 4.2 7 13 28 133.0 7.0 7 16 10 341.8 6.1 7 9 8 250.4 3.6 7 11 17 203.0 3.9 7 13 29 145.1 6.3 7 16 11 486.9 8.4 7 9 9 103.4 4.8 7 11 18 168.7 4.0 7 13 30 160.3 6.2 7 16 12 354.0 5.4 7 9 10 22.2 10.5 7 11 19 167.8 4.8 7 14 0 397.9 6.7 7 16 13 200.6 3.7 7 9 11 302.3 4.4 7 11 20 126.7 4.4 7 14 1 736.4 14.6 7 16 14 87.5 6.1 7 9 12 285.3 10.2 7 11 21 176.1 4.2 7 14 2 184.7 3.5 7 16 15 180.2 3.9 7 9 13 508.3 7.3 7 11 22 124.5 4.7 7 14 3 336.2 5.5 7 16 16 425.5 6.2 7 9 14 214.7 4.1 7 11 23 170.9 4.1 7 14 4 787.7 11.2 7 16 17 118.3 4.0 7 9 15 353.7 5.7 7 11 24 102.6 5.9 7 14 5 353.4 5.1 7 16 18 69.4 6.6 7 9 16 214.6 4.2 7 11 25 173.9 6.2 7 14 6 244.4 5.0 7 16 19 89.1 6.5 7 9 17 240.9 4.3 7 11 27 38.1 14.2 7 14 7 220.9 3.9 7 16 20 136.9 4.4 7 9 18 24.3 11.0 7 11 28 131.1 6.6 7 14 8 237.0 5.0 7 16 21 25.6 11.2 7 9 19 27.6 11.6 7 11 29 27.1 12.4 7 14 9 312.8 12.4 7 16 22 108.2 4.6 7 9 20 194.1 4.1 7 11 30 87.1 10.1 7 14 10 349.8 5.3 7 16 23 247.5 4.6 7 9 21 141.1 4.5 7 12 0 477.5 7.9 7 14 11 586.9 11.3 7 16 24 316.9 9.1 7 9 22 180.3 4.8 7 12 1 241.1 4.9 7 14 12 609.1 8.5 7 16 25 63.6 15.1 7 9 23 217.0 4.1 7 12 2 414.5 6.0 7 14 13 364.7 5.7 7 16 26 99.2 8.0 7 9 24 209.2 4.2 7 12 3 662.6 10.4 7 14 14 168.0 4.1 7 16 27 171.3 5.5 WO 99/10379 PCT/GB98/02542 -132 7 16 28 41.1 1.5.3 7 19 13 315.1 5.0 7 22 1 142.1 3.3 7 24 19 32.4 14.5 7 16 29 24.6 12.4 7 19 14 227.8 4.5 7 22 2 172.6 6.1 7 24 20 17.2 8.7 7 17 0 381.5 6.3 7 19 15 303.1 4.6 7 22 3 283.8 4.7 7 24 21 171.3 4.7 7 17 1 217.8 5.1 7 19 16 201.8 3.8 7 22 4 394.2 5.7 7 24 22 124.4 8.2 7 17 2 180.9 3.6 7 19 17 188.6 4.2 7 22 5 350.4 5.0 7 24 23 70.9 9.1 7 17 3 585.0 7.6 7 19 18 230.0 4.0 7 22 6 313.2 4.8 7 24 24 67.4 11.1 7 17 4 304.9 7.8 7 19 19 273.1 4.0 7 22 7 258.7 4.2 7 24 25 25.1 11.7 7 17 5 400.0 13.7 7 19 20 129.5 4.9 7 22 8 166.3 3.3 7 25 0 293.8 4.6 7 17 6 325.8 5.1 7 19 21 203.4 3.9 7 22 9 323.1 4.8 7 25 1 396.4 8.5 7 17 7 223.8 3.9 7 19 22 38.8 14.5 7 22 10 205.5 3.3 7 25 2 227.4 4.5 7 17 8 162.3 5.4 7 19 23 18.6 9.3 7 22 11 76.7 3.9 7 25 3 53.1 7.2 7 17 9 386.3 6.3 7 19 24 114.3 7.5 7 22 12 71.6 5.3 7 25 4 248.0 4.1 7 17 10 162.8 3.4 7 19 25 259.6 5.1 7 22 13 202.5 4.4 7 25 5 206.6 3.3 7 17 11 202.2 3.4 7 19 26 35.9 15.6 7 22 14 15.5 7.7 7 25 6 213.5 3.5 7 17 12 171.9 3.8 7 19 27 20.7 10.4 7 22 15 110.1 3.6 7 25 7 335.2 4.9 7 17 13 75.6 4.5 7 19 28 143.0 7.7 7 22 16 165.5 3.4 7 25 8 97.8 3.2 7 17 14 427.0 6.7 7 20 0 110.0 4.6 7 22 17 147.3 4.1 7 25 9 73.9 4.0 7 17 15 145.8 3.6 7 20 1 149.1 3.5 7 22 18 147.0 3.8 7 25 10 148.0 3.3 7 17 16 159.1 4.1 7 20 2 342.5 7.1 7 22 19 122.0 4.4 7 25 11 323.7 4.6 7 17 17 46.4 9.9 7 20 3 108.7 4.5 7 22 20 274.5 5.5 7 25 12 80.0 4.5 7 17 18 167.9 3.7 7 20 4 193.2 5.3 7 22 21 172.8 23.5 7 25 13 90.6 4.3 7 17 19 70.4 5.9 7 20 5 328.1 5.2 7 22 22 189.9 4.4 7 25 14 214.0 3.4 7 17 20 160.5 3.8 7 20 6 96.1 3.4 7 22 23 72.9 7.4 7 25 15 106.4 4.1 7 17 21 83.2 6.9 7 20 7 69.7 6.1 7 22 24 102.6 6.5 7 25 16 166.5 4.1 7 17 22 111.6 5.3 7 20 8 210.9 3.3 7 22 25 112.1 7.5 7 25 17 89.5 4.9 7 17 23 68.1 9.9 7 20 9 240.8 3.9 7 22 26 88.9 8.6 7 25 18 222.9 4.7 7 17 24 22.6 10.8 7 20 10 184.5 3.3 7 23 0 93.3 2.5 7 25 19 63.5 11.9 7 17 25 175.5 5.0 7 20 11 334.8 4.8 7 23 1 308.6 6.6 7 25 20 214.1 5.4 7 17 26 50.4 14.5 7 20 12 122.3 3.7 7 23 2 133.5 4.1 7 25 21 133.1 4.2 7 17 28 110.1 6.7 7 20 13 190.9 3.5 7 23 3 282.1 6.2 7 25 22 170.8 5.0 7 18 0 520.9 9.5 7 20 14 109.1 3.9 7 23 4 28.4 11.4 7 25 23 93.9 8.3 7 18 1 563.6 9.7 7 20 15 59.0 5.5 7 23 5 147.1 3.6 7 25 24 178.2 5.2 7 18 2 373.0 12.1 7 20 16 182.5 3.5 7 23 6 198.4 3.8 7 25 25 103.6 10.5 7 18 3 930.0 24.4 7 20 17 129.4 3.4 7 23 7 89.0 3.7 7 26 0 276.7 8.6 7 18 4 354.9 5.5 7 20 18 187.6 3.8 7 23 8 19.3 8.8 7 26 1 217.4 4.4 7 18 5 626.4 10.1 7 20 19 292.6 4.9 7 23 9 104.4 3.2 7 26 2 185.2 4.1 7 18 6 250.5 4.0 7 20 20 139.8 3.9 7 23 10 188.4 3.1 7 26 3 136.7 3.6 7 18 7 346.4 4.7 7 20 21 16.8 8.4 7 23 11 300.4 5.2 7 26 4 233.1 4.0 7 18 8 18.6 9.1 7 20 22 290.4 9.6 7 23 12 194.9 3.3 7 26 5 308.0 5.1 7 18 9 329.0 6.3 7 20 23 87.3 7.0 7 23 13 231.6 4.7 7 26 6 179.8 3.0 7 18 10 267.1 4.6 7 20 24 194.7 5.0 7 23 14 166.0 3.4 7 26 7 76.7 3.3 7 18 11 69.5 5.5 7 20 25 162.5 5.2 7 23 15 128.5 3.7 7 26 8 123.7 2.9 7 18 12 37.7 10.0 7 20 26 184.2 5.6 7 23 16 72.5 6.1 7 26 9 159.1 3.4 7 18 13 311.0 4.6 7 20 27 26.0 12.0 7 23 17 156.9 3.7 7 26 10 13.7 6.7 7 18 14 216.3 3.7 7 21 0 73.9 6.1 7 23 18 100.1 5.0 7 26 11 17.4 8.3 7 18 15 89.7 4.6 7 21 1 195.4 4.2 7 23 19 154.7 3.9 7 26 12 159.7 3.2 7 18 16 16.3 8.0 7 21 2 267.1 4.6 7 23 20 168.9 16.1 7 26 13 162.1 3.3 7 18 17 143.6 3.6 7 21 3 287.0 4.8 7 23 21 17.1 8.4 7 26 14 252.0 4.1 7 18 18 170.2 3.6 7 21 4 489.5 8.1 7 23 22 15.1 7.7 7 26 15 148.7 3.5 7 18 19 133.0 3.8 7 21 5 403.5 6.1 7 23 23 275.8 4.5 7 26 16 114.3 4.3 7 18 20 65.8 9.4 7 21 6 282.4 4.0 7 23 24 180.3 4.7 7 26 17 39.7 12.7 7 18 21 109.2 5.5 7 21 7 236.1 3.6 7 23 25 141.4 5.1 7 26 18 316.4 13.0 7 18 22 127.8 5.1 7 21 8 342.9 4.9 7 23 26 70.2 13.0 7 26 19 138.9 4.9 7 18 23 345.4 15.2 7 21 9 355.0 5.5 7 24 0 246.5 4.2 7 26 20 61.6 8.3 7 18 24 99.5 6.9 7 21 10 252.8 4.8 7 24 1 242.2 4.5 7 26 21 115.3 5.5 7 18 25 135.6 5.5 7 21 11 138.9 3.4 7 24 2 542.4 9.5 7 26 22 92.1 7.9 7 18 26 141.0 6.3 7 21 12 340.0 4.8 7 24 3 388.6 7.5 7 26 23 44.6 12.2 7 18 27 26.4 12.0 7 21 13 88.3 5.4 7 24 4 452.8 7.7 7 26 24 28.4 13.5 7 18 28 65.3 12.5 7 21 14 148.5 3.4 7 24 5 371.7 6.3 7 27 0 71.5 5.1 7 19 0 105.6 5.1 7 21 15 25.9 10.9 7 24 6 92.9 3.4 7 27 1 176.8 3.9 7 19 1 28.6 11.1 7 21 16 77.0 5.8 7 24 7 154.6 3.4 7 27 2 168.8 5.5 7 19 2 391.2 7.5 7 21 17 27.7 11.5 7 24 8 34.4 9.1 7 27 3 203.0 4.7 7 19 3 106.0 4.6 7 21 18 147.1 4.4 7 24 9 89.2 3.4 7 27 4 182.5 3.5 7 19 4 194.5 3.4 7 21 19 254.1 4.2 7 24 10 180.0 3.1 7 27 5 159.5 3.4 7 19 5 444.8 7.1 7 21 20 250.0 4.5 7 24 11 112.2 3.6 7 27 6 155.0 2.7 7 19 6 246.4 4.3 7 21 22 55.7 13.4 7 24 12 203.4 4.0 7 27 7 282.1 4.1 7 19 7 32.9 8.9 7 21 23 154.3 5.3 7 24 13 154.3 3.8 7 27 8 353.3 5.3 7 19 8 192.4 3.6 7 21 24 221.4 9.2 7 24 14 190.1 3.6 7 27 9 94.5 4.2 7 19 9 534.0 7.6 7 21 25 26.7 11.9 7 24 15 229.6 3.8 7 27 10 46.2 6.5 7 19 10 149.1 4.0 7 21 26 180.2 6.0 7 24 16 119.7 3.5 7 27 11 28.0 10.0 7 19 11 202.0 3.5 7 21 27 84.0 9.6 7 24 17 179.3 3.6 7 27 12 96.3 3.8 7 19 12 112.3 6.3 7 22 0 468.7 10.3 7 24 18 152.7 5.1 7 27 13 189.6 3.4 WO 99/10379 PCT/GB98/02542 -133 7 27 14 94.4 4.3 7 30 18 130.9 5.6 7 34 9 210.7 3.8 7 40 1 94.8 3.7 7 27 15 187.8 3.8 7 30 19 117.3 5.7 7 34 10 62.4 5.4 7 40 2 56.2 5.8 7 27 16 153.7 4.3 7 30 20 94.3 10.0 7 34 11 145.5 3.5 7 40 3 51.7 6.6 7 27 17 131.6 17.2 7 30 21 65.2 10.6 7 34 12 202.7 4.0 7 40 4 94.0 4.3 7 27 18 19.1 9.0 7 31 0 27.5 9.3 7 34 13 129.9 3.7 8 0 0 7.8 5.8 7 27 19 177.8 4.3 7 31 1 94.1 3.6 7 34 14 121.7 3.8 8 0 1 641.2 14.5 7 27 20 146.9 6.5 7 31 2 198.0 4.6 7 34 15 173.1 3.7 8 0 2 80.8 5.1 7 27 21 51.5 11.2 7 31 3 199.9 3.7 7 34 16 77.9 6.4 8 0 3 94.4 4.0 7 27 22 84.3 6.6 7 31 4 273.5 5.2 7 34 17 74.2 8.0 8 0 4 299.5 6.2 7 27 23 99.9 6.8 7 31 5 232.3 5.0 7 35 0 100.6 6.1 8 0 5 459.2 8.2 7 28 0 26.1 9.2 7 31 6 66.4 4.1 7 35 3 71.8 7.7 8 0 6 349.9 8.1 7 28 1 60.1 5.6 7 31 7 106.4 3.2 7 35 4 177.0 4.1 8 0 7 13.3 9.5 7 28 2 183.7 4.0 7 31 8 265.6 4.1 7 35 5 17.2 8.0 8 0 8 953.9 19.7 7 28 3 157.5 5.1 7 31 9 120.4 3.1 7 35 6 33.4 10.3 8 0 9 145.6 5.7 7 28 4 137.8 3.5 7 31 10 108.3 3.9 7 35 7 224.1 3.8 8 0 10 19.2 12.7 7 28 5 200.8 3.4 7 31 11 84.9 7.4 7 35 8 121.3 3.6 8 0 11 204.5 14.7 7 28 6 151.1 3.2 7 31 12 187.3 11.7 7 35 9 90.8 4.8 8 0 13 194.3 6.4 7 28 7 15.9 7.4 7 31 13 294.8 5.0 7 35 10 166.1 3.4 8 0 14 90.0 10.4 7 28 8 108.7 3.2 7 31 14 159.1 3.9 7 35 11 123.8 3.6 8 0 15 730.4 16.6 7 28 9 90.6 4.0 7 31 15 200.5 3.8 7 35 12 166.4 3.4 8 0 16 210.3 6.0 7 28 10 114.2 5.0 7 31 16 30.8 11.0 7 35 13 171.3 3.8 8 0 17 63.5 23.6 7 28 11 153.5 3.7 7 31 17 139.6 5.5 7 35 14 144.1 4.6 8 0 18 378.4 7.2 7 28 12 219.2 3.6 7 31 18 162.2 4.2 7 35 15 52.9 11.0 8 0 19 136.5 6.9 7 28 13 210.5 3.5 7 31 19 126.9 4.5 7 36 0 65.9 5.2 8 0 21 45.4 22.3 7 28 14 80.5 4.8 7 31 20 87.5 6.9 7 36 1 151.6 4.1 8 0 22 238.4 6.3 7 28 16 194.6 11.2 7 32 0 223.1 4.8 7 36 2 195.3 4.5 8 0 23 14.9 10.7 7 28 17 238.6 4.1 7 32 1 108.4 3.6 7 36 3 25.7 9.8 8 0 24 34.2 21.5 7 28 18 78.3 5.5 7 32 2 154.1 3.6 7 36 4 68.3 6.7 8 0 25 73.0 13.4 7 28 19 76.1 8.5 7 32 3 35.8 9.8 7 36 5 116.6 4.1 8 0 26 151.9 10.6 7 28 20 134.2 5.3 7 32 4 156.9 3.7 7 36 6 238.1 5.5 8 0 27 83.2 12.1 7 28 21 81.3 8.9 7 32 5 124.7 3.7 7 36 7 207.4 4.4 8 0 28 316.0 8.0 7 28 22 92.7 7.0 7 32 6 39.4 9.3 7 36 8 118.4 3.4 8 0 29 303.1 12.4 7 29 0 287.2 5.5 7 32 7 149.8 3.7 7 36 9 87.1 4.5 8 0 30 65.6 21.4 7 29 1 224.0 5.6 7 32 8 142.4 3.0 7 36 10 87.6 4.6 8 0 31 22.2 15.8 7 29 2 131.9 3.2 7 32 9 121.1 4.6 7 36 11 171.4 3.4 8 1 0 87.7 2.6 7 29 3 17.6 8.1 7 32 10 185.9 10.2 7 36 12 185.5 3.6 8 1 1 296.0 4.6 7 29 4 74.0 7.1 7 32 11 147.4 3.7 7 36 13 70.0 6.7 8 1 2 50.4 5.2 7 29 5 301.7 5.0 7 32 12 98.0 4.5 7 36 14 103.7 5.2 8 1 3 235.9 3.8 7 29 6 148.9 2.9 7 32 13 108.1 4.0 7 37 0 275.2 6.4 8 1 4 293.8 4.1 7 29 7 303.8 4.5 7 32 14 84.1 4.7 7 37 1 155.7 3.3 8 1 5 91.8 4.2 7 29 8 92.9 3.5 7 32 15 72.9 6.7 7 37 2 64.9 5.2 8 1 6 598.8 9.0 7 29 9 212.0 3.1 7 32 16 164.6 3.8 7 37 3 107.8 4.1 8 1 7 642.7 9.7 7 29 10 228.4 3.5 7 32 17 196.8 3.9 7 37 4 184.5 4.4 8 1 8 258.8 4.4 7 29 11 241.6 3.6 7 32 18 66.2 7.4 7 37 5 186.6 4.1 8 1 9 372.4 5.6 7 29 12 49.5 7.8 7 32 19 102.3 7.2 7 37 6 106.5 6.5 8 1 10 294.7 4.4 7 29 13 64.7 6.1 7 33 0 35.1 8.1 7 37 7 83.8 4.0 8 1 11 766.5 10.7 7 29 14 296.2 6.8 7 33 1 91.8 5.8 7 37 8 134.2 4.8 8 1 12 127.4 7.8 7 29 15 36.1 15.0 7 33 2 187.1 4.0 7 37 9 123.9 3.1 8 1 13 422.7 6.0 7 29 16 83.8 4.9 7 33 3 210.0 4.7 7 37 10 108.5 3.8 8 1 14 397.3 6.3 7 29 17 26.2 11.4 7 33 4 93.0 4.5 7 37 11 106.8 3.9 8 1 15 84.0 8.2 7 29 18 95.8 5.9 7 33 5 231.3 5.5 7 37 12 43.0 10.7 8 1 16 413.4 6.2 7 29 19 159.7 5.0 7 33 6 66.2 5.0 7 38 0 246.9 5.1 8 1 17 107.4 7.0 7 29 20 227.2 5.0 7 33 7 145.2 8.2 7 38 1 62.8 5.1 8 1 18 89.2 7.6 7 29 21 113.4 5.5 7 33 8 213.6 9.0 7 38 2 177.6 4.3 8 1 19 121.0 6.4 7 29 22 97.9 6.2 7 33 10 116.3 4.2 7 38 3 38.3 9.4 8 1 20 109.0 6.2 7 30 0 248.7 4.2 7 33 11 25.4 10.1 7 38 4 276.9 5.4 8 1 21 36.3 13.7 7 30 1 194.4 3.8 7 33 12 140.7 4.4 7 38 5 60.2 6.4 8 1 22 196.4 4.6 7 30 2 232.9 5.1 7 33 13 89.5 4.3 7 38 6 88.5 4.8 8 1 23 156.4 4.4 7 30 3 299.6 5.7 7 33 14 95.7 4.6 7 38 7 83.8 5.3 8 1 24 44.0 14.1 7 30 4 268.7 5.4 7 33 15 77.9 6.5 7 38 8 198.9 3.6 8 1 25 47.3 13.4 7 30 5 237.3 4.2 7 33 16 163.8 3.9 7 38 9 23.4 9.0 8 1 26 31.1 15.3 7 30 6 131.1 2.7 7 33 17 147.2 5.3 7 38 10 41.1 9.9 8 1 27 73.8 9.6 7 30 7 142.4 3.1 7 33 18 162.7 4.8 7 39 0 40.0 7.7 8 1 28 185.7 5.9 7 30 8 70.1 4.6 7 34 0 173.5 4.4 7 39 1 186.0 4.0 8 1 29 164.0 6.9 7 30 9 222.4 3.2 7 34 1 64.8 6.3 7 39 2 129.5 3.5 8 1 30 110.5 9.0 7 30 10 55.0 5.5 7 34 2 314.1 6.1 7 39 3 93.6 3.8 8 1 31 72.2 13.8 7 30 11 147.8 3.9 7 34 3 59.5 14.0 7 39 4 174.6 3.9 8 2 0 34.0 6.6 7 30 12 147.4 3.6 7 34 4 323.7 16.6 7 39 5 44.1 9.0 8 2 1 175.2 3.5 7 30 13 291.9 13.5 7 34 5 275.9 8.7 7 39 6 71.2 5.3 8 2 2 340.4 5.0 7 30 15 218.1 4.2 7 34 6 159.5 3.7 7 39 7 177.9 4.1 8 2 3 546.8 7.5 7 30 16 176.2 4.0 7 34 7 73.8 4.5 7 39 8 78.8 7.3 8 2 4 307.6 4.5 7 30 17 136.3 4.0 7 34 8 244.7 3.9 7 40 0 82.0 3.5 8 2 5 122.9 3.0 WO 99/10379 PCT/GB98/02542 -134 8 2 6 37.3 12.5 8 4 14 149.7 5.8 8 6 24 97.6 6.1 8 9 4 609.2 10.2 8 2 7 223.4 3.7 8 4 15 325.0 5.5 8 6 25 163.9 4.9 8 9 5 36.6 10.9 8 2 8 339.7 5.1 8 4 16 259.5 4.3 8 6 26 277.0 13.2 8 9 6 102.0 3.7 8 2 9 131.8 4.0 8 4 17 211.4 4.0 8 6 27 184.7 6.1 8 9 7 168.8 3.4 8 2 10 265.6 4.0 8 4 18 162.2 4.7 8 6 28 164.4 7.3 8 9 8 128.9 7.1 8 2 11 381.9 6.8 8 4 19 48.4 12.9 8 6 29 70.7 16.1 8 9 9 503.9 7.0 8 2 12 246.1 9.3 8 4 20 56.8 10.2 8 6 30 182.1 8.2 8 9 11 180.2 4.3 8 2 13 374.3 5.6 8 4 21 181.3 4.1 8 7 0 452.1 7.6 8 9 12 197.0 5.9 8 2 14 290.0 5.1 8 4 22 233.5 4.9 8 7 1 341.6 6.2 8 9 13 226.8 4.4 8 2 15 109.6 5.4 8 4 23 83.6 8.2 8 7 2 385.7 5.6 8 9 14 214.9 4.1 8 2 16 213.0 4.7 8 4 24 176.8 4.8 8 7 3 305.8 4.2 8 9 15 90.0 7.3 8 2 17 123.0 5.1 8 4 25 31.0 13.2 8 7 4 335.4 4.8 8 9 16 164.1 4.5 8 2 18 224.1 4.2 8 4 26 248.4 11.2 8 7 5 363.3 5.2 8 9 17 510.2 8.0 8 2 19 256.8 4.7 8 4 27 67.6 10.5 8 7 6 525.6 8.2 8 9 18 53.9 8.2 8 2 20 98.9 5.9 8 4 28 148.9 7.1 8 7 7 299.2 4.7 8 9 19 126.7 4.4 8 2 21 155.4 5.1 8 4 29 134.3 8.4 8 7 8 430.7 7.1 8 9 20 69.7 8.3 8 2 22 203.7 4.6 8 4 30 192.9 6.0 8 7 9 185.9 4.6 8 9 21 43.0 11.3 8 2 23 66.8 8.3 8 5 0 297.6 4.4 8 7 10 345.8 5.4 8 9 22 173.0 4.5 8 2 24 150.0 5.0 8 5 1 109.0 3.2 8 7 11 407.5 14.7 8 9 23 114.8 5.6 8 2 25 34.0 13.0 8 5 2 331.0 4.8 8 7 12 499.9 6.9 8 9 24 142.3 4.8 8 2 26 153.0 11.6 8 5 3 290.3 4.4 8 7 13 190.8 4.2 8 9 25 70.7 26.1 8 2 27 144.4 5.0 8 5 4 223.3 3.5 8 7 14 155.8 4.5 8 9 26 151.0 6.2 8 2 28 177.6 5.4 8 5 5 264.0 4.1 8 7 15 260.9 4.9 8 9 27 102.5 6.9 8 2 29 147.3 9.2 8 5 6 518.7 7.8 8 7 16 96.5 5.7 8 9 28 76.1 10.3 8 2 30 100.5 10.7 8 5 7 622.2 10.6 8 7 17 274.9 4.3 8 9 29 63.6 16.8 8 2 31 22.6 11.3 8 5 8 30.2 9.4 8 7 18 303.1 4.5 8 9 30 188.9 5.5 8 3 0 397.5 6.3 8 5 9 402.3 6.6 8 7 19 243.7 4.1 8 10 0 430.6 6.8 8 3 1 217.3 3.8 8 5 10 587.9 10.6 8 7 20 105.0 7.2 8 10 1 337.3 5.9 8 3 2 357.5 5.3 8 5 11 119.3 4.2 8 7 21 18.7 9.5 8 10 2 186.5 3.2 8 3 3 109.9 3.6 8 5 12 342.7 19.5 8 7 22 143.6 4.7 8 10 3 193.3 3.5 8 3 4 151.9 3.0 8 5 13 36.8 13.6 8 7 23 68.2 8.0 8 10 4 17.4 8.1 8 3 5 49.9 6.0 8 5 14 372.6 5.9 8 7 24 45.6 14.2 8 10 5 377.3 5.5 8 3 6 283.6 4.1 8 5 15 123.9 6.7 8 7 25 94.2 7.2 8 10 6 166.7 3.1 8 3 7 81.3 4.8 8 5 16 408.8 5.7 8 7 26 85.7 20.9 8 10 7 234.2 4.1 8 3 8 421.3 6.1 8 5 17 236.4 4.2 8 7 27 91.5 8.6 8 10 8 382.6 6.4 8 3 9 283.4 4.9 8 5 18 216.6 4.6 8 7 28 103.2 9.3 8 10 9 335.7 5.2 8 3 10 191.0 4.9 8 5 19 233.0 4.4 8 7 29 77.5 17.8 8 10 10 305.1 17.5 8 3 11 158.7 5.6 8 5 20 107.5 5.4 8 7 30 173.3 6.2 8 10 11 631.4 8.7 8 3 12 559.6 18.3 8 5 21 82.4 6.8 8 8 0 757.9 12.7 8 10 12 88.6 6.4 8 3 13 179.7 4.2 8 5 22 63.4 8.9 8 8 1 382.8 6.4 8 10 13 91.6 5.7 8 3 14 200.6 4.7 8 5 23 19.4 9.4 8 8 2 646.4 9.7 8 10 14 247.3 3.9 8 3 15 395.2 5.7 8 5 24 186.7 4.2 8 8 3 462.2 7.0 8 10 15 272.2 5.1 8 3 16 221.9 4.2 8 5 25 154.9 6.4 8 8 4 234.7 3.8 8 10 16 248.1 4.3 8 3 17 172.3 4.2 8 5 26 409.3 11.9 8 8 5 364.7 5.2 8 10 17 130.6 4.5 8 3 18 310.7 4.8 8 5 27 89.2 9.1 8 8 6 228.2 3.4 8 10 18 238.4 4.1 8 3 19 223.9 5.2 8 5 28 139.1 9.6 8 8 7 245.5 4.0 8 10 19 50.5 9.6 8 3 20 274.9 4.5 8 5 29 68.5 13.7 8 8 8 103.5 6.2 8 10 20 102.3 4.9 8 3 21 100.9 6.2 8 5 30 31.5 14.0 8 8 9 409.8 6.1 8 10 21 33.8 11.6 8 3 22 134.4 4.6 8 6 0 26.0 7.9 8 8 10 464.5 6.5 8 10 22 53.3 10.9 8 3 23 169.1 4.2 8 6 1 588.4 11.4 8 8 11 416.2 16.7 8 10 23 94.5 8.0 8 3 24 128.0 5.6 8 6 2 140.2 2.8 8 8 12 178.5 4.1 8 10 24 26.2 11.6 8 3 25 27.4 12.1 8 6 3 207.5 3.2 8 8 13 168.9 5.2 8 10 25 397.4 13.7 8 3 26 270.2 18.8 8 6 4 43.9 9.3 8 8 14 182.9 4.1 8 10 26 97.4 7.0 8 3 27 104.8 6.6 8 6 5 56.9 8.3 8 8 15 344.9 5.5 8 10 27 22.8 11.3 8 3 28 226.2 5.3 8 6 6 678.8 9.4 8 8 16 123.8 4.6 8 10 28 105.0 8.8 8 3 29 248.0 6.1 8 6 7 305.3 5.0 8 8 17 205.7 4.6 8 10 29 33.1 15.1 8 3 30 59.7 15.1 8 6 8 185.9 3.9 8 8 18 230.3 4.4 8 10 30 53.6 19.0 8 3 31 160.9 7.5 8 6 9 264.0 4.5 8 8 19 79.8 6.2 8 11 0 451.3 6.3 8 4 0 453.1 6.0 8 6 10 675.3 9.8 8 8 20 167.4 4.6 8 11 1 316.6 5.1 8 4 1 83.0 3.9 8 6 11 37.9 14.5 8 8 21 148.0 4.4 8 11 2 560.8 9.6 8 4 2 506.0 7.0 8 6 12 115.7 10.4 8 8 22 130.2 4.8 8 11 3 754.3 9.9 8 4 3 254.7 4.1 8 6 13 352.0 5.2 8 8 23 127.6 4.9 8 11 4 312.4 4.3 8 4 4 73.7 4.3 8 6 14 304.9 5.3 8 8 24 184.2 4.8 8 11 5 116.6 4.4 8 4 5 222.7 3.7 8 6 15 96.1 9.2 8 8 26 29.6 13.9 8 11 6 468.2 7.0 8 4 6 146.5 3.3 8 6 16 354.0 5.1 8 8 27 49.6 14.5 8 11 7 537.6 10.6 8 4 7 91.7 5.6 8 6 17 79.8 9.7 8 8 28 101.5 9.8 8 11 8 54.6 8.8 8 4 8 554.7 8.4 8 6 18 65.5 7.6 8 8 29 105.2 8.7 8 11 9 352.3 9.6 8 4 9 510.5 8.0 8 6 19 161.4 4.1 8 8 30 32.8 14.2 8 11 10 325.0 4.8 8 4 10 512.6 7.4 8 6 20 157.1 4.3 8 9 0 494.8 8.6 8 11 11 426.7 7.3 8 4 11 238.1 4.1 8 6 21 237.9 4.2 8 9 1 210.1 3.9 8 11 12 307.0 4.9 8 4 12 748.3 19.7 8 6 22 66.0 9.0 8 9 2 313.2 4.5 8 11 13 111.0 4.6 8 4 13 225.7 4.2 8 6 23 71.5 8.3 8 9 3 252.4 3.8 8 11 14 220.8 4.1 WO 99/10379 PCT/GB98/02542 -135 8 11 15 322.6 5.1 8 13 28 41.1 16.7 8 16 14 299.7 4.6 8 19 2 21.2 8.2 8 11 16 158.8 3.9 8 13 29 81.6 11.0 8 16 15 84.2 5.8 8 19 3 446.3 6.7 8 11 17 217.0 5.4 8 14 0 328.6 5.9 8 16 16 192.4 3.7 8 19 4 538.6 8.3 8 11 18 119.3 4.7 8 14 1 308.8 5.5 8 16 17 107.5 5.2 8 19 5 331.5 4.7 8 11 19 81.2 5.9 8 14 2 660.6 11.7 8 16 18 56.1 8.1 8 19 6 233.3 3.7 8 11 20 116.4 5.1 8 14 3 259.6 5.9 8 16 19 227.1 4.1 8 19 7 298.0 4.4 8 11 21 137.6 5.0 8 14 4 79.8 4.4 8 16 20 130.3 4.0 8 19 8 291.8 4.5 8 11 22 107.6 7.4 8 14 5 504.0 8.3 8 16 21 227.0 4.4 8 19 9 251.0 4.1 8 11 23 94.4 7.0 8 14 7 184.0 4.3 8 16 22 88.5 6.9 8 19 10 230.3 3.6 8 11 24 21.2 10.2 8 14 8 17.7 8.5 8 16 23 395.5 16.9 8 19 11 221.1 4.3 8 11 25 182.5 16.2 8 14 9 148.4 5.3 8 16 24 114.9 6.3 8 19 12 207.3 3.6 8 11 26 104.3 6.4 8 14 10 283.6 4.9 8 16 25 100.2 7.5 8 19 13 256.1 4.2 8 11 27 202.8 5.9 8 14 11 306.9 5.4 8 16 26 70.9 10.1 8 19 14 152.2 3.4 8 11 28 110.1 8.6 8 14 12 425.2 6.9 8 16 27 218.8 5.5 8 19 15 355.2 4.7 8 11 29 172.8 6.3 8 14 13 292.7 4.8 8 16 28 128.9 6.6 8 19 16 320.8 4.5 8 12 0 268.4 4.0 8 14 14 198.0 3.9 8 17 0 362.6 9.9 8 19 17 111.6 4.0 8 12 1 346.1 5.8 8 14 15 314.3 5.0 8 17 1 333.3 5.5 8 19 18 119.4 4.5 8 12 2 379.5 7.1 8 14 16 208.1 4.8 8 17 2 119.7 4.5 8 19 19 90.7 6.7 8 12 3 168.5 3.2 8 14 17 141.6 4.5 8 17 3 259.7 4.3 8 19 20 139.6 4.3 8 12 4 289.6 5.5 8 14 18 32.5 12.3 8 17 4 189.5 3.8 8 19 21 56.4 10.6 8 12 5 269.2 4.8 8 14 19 112.1 4.6 8 17 5 131.6 3.5 8 19 23 231.6 4.8 8 12 6 294.1 6.3 8 14 20 17.6 8.8 8 17 6 17.9 8.3 8 19 24 163.3 9.1 8 12 7 25.2 11.5 8 14 21 161.0 5.1 8 17 7 186.6 3.4 8 19 25 80.1 8.9 8 12 9 23.1 11.0 8 14 22 67.3 10.1 8 17 8 170.4 3.5 8 19 26 164.8 6.8 8 12 10 521.3 7.9 8 14 23 115.2 6.0 8 17 9 151.9 3.8 8 19 27 96.1 7.1 8 12 11 49.1 10.9 8 14 24 175.3 11.4 8 17 10 38.7 11.7 8 20 0 389.2 7.4 8 12 12 69.7 7.1 8 14 25 147.9 5.3 8 17 11 355.7 5.7 8 20 1 122.4 4.7 8 12 13 112.2 4.6 8 14 26 86.0 9.6 8 17 12 84.5 5.3 8 20 2 146.0 3.3 8 12 14 246.8 5.1 8 14 27 130.1 8.4 8 17 13 167.8 3.6 8 20 3 183.6 3.6 8 12 15 339.9 5.1 8 14 28 113.4 8.5 8 17 14 95.8 5.0 8 20 4 446.9 7.4 8 12 16 190.0 4.1 8 14 29 78.5 11.7 8 17 15 244.6 3.8 8 20 5 325.6 4.8 8 12 17 218.0 3.9 8 15 0 471.2 7.7 8 17 16 296.4 4.5 8 20 6 60.8 5.8 8 12 18 137.9 4.6 8 15 1 500.2 8.1 8 17 17 269.7 4.5 8 20 7 261.3 4.0 8 12 19 193.2 3.8 8 15 2 183.8 4.7 8 17 18 16.9 8.3 8 20 8 386.9 6.7 8 12 20 102.6 4.9 8 15 3 265.6 4.0 8 17 19 69.5 8.6 8 20 9 173.7 3.3 8 12 21 268.8 4.5 8 15 4 310.4 12.6 8 17 20 193.6 4.3 8 20 10 15.5 7.7 8 12 22 122.5 6.2 8 15 5 290.1 13.0 8 17 21 53.3 13.9 8 20 11 328.2 5.7 8 12 23 303.6 4.8 8 15 6 840.5 12.6 8 17 24 75.1 9.1 8 20 12 121.9 4.5 8 12 24 90.7 8.0 8 15 7 240.2 3.9 8 17 25 69.4 11.3 8 20 13 88.5 4.8 8 12 25 110.8 7.9 8 15 8 250.1 4.0 8 17 26 118.4 8.3 8 20 14 48.5 12.0 8 12 26 34.4 15.7 8 15 9 476.2 7.0 8 17 27 24.1 11.8 8 20 15 63.4 7.0 8 12 27 238.3 5.2 8 15 10 302.7 5.0 8 17 28 53.9 16.0 8 20 16 78.5 5.0 8 12 28 111.2 8.7 8 15 11 16.9 8.4 8 18 0 279.3 4.3 8 20 17 77.8 5.9 8 12 29 128.8 6.5 8 15 12 69.0 6.1 8 18 1 275.0 4.8 8 20 18 80.6 6.6 8 13 0 229.0 3.8 8 15 13 221.0 3.8 8 18 2 247.6 6.2 8 20 19 85.5 6.4 8 13 1 17.2 7.6 8 15 14 254.7 4.4 8 18 3 292.7 4.9 8 20 20 209.4 4.1 8 13 2 168.8 3.0 8 15 15 214.3 3.7 8 18 4 332.1 4.8 8 20 21 328.0 18.0 8 13 3 897.6 12.4 8 15 16 154.5 4.7 8 18 5 190.1 3.4 8 20 22 87.6 6.8 8 13 4 336.8 6.3 8 15 17 119.2 3.8 8 18 6 135.3 3.5 8 20 23 160.6 5.7 8 13 5 544.3 7.8 8 15 18 147.0 4.0 8 18 7 248.3 4.0 8 20 24 172.7 4.8 8 13 6 212.8 3.9 8 15 19 81.4 6.5 8 18 8 228.5 3.8 8 20 25 318.9 5.4 8 1.3 7 578.0 18.5 8 15 20 77.5 5.9 8 18 9 207.5 3.7 8 20 26 119.3 7.0 8 13 8 388.3 6.2 8 15 21 90.7 6.5 8 18 10 141.1 3.4 8 21 0 383.8 6.1 8 13 9 776.7 15.8 8 15 22 158.6 4.9 8 18 11 168.1 3.6 8 21 1 264.3 5.7 8 13 10 329.1 6.6 8 15 23 139.2 5.3 8 18 12 130.0 3.6 8 21 2 386.5 6.2 8 13 11 155.9 4.4 8 15 24 21.5 10.4 8 18 13 191.6 3.7 8 21 3 297.3 6.3 8 13 12 230.1 4.9 8 15 25 156.1 5.9 8 18 14 189.4 3.7 8 21 4 121.5 4.0 8 13 13 435.2 6.3 8 15 26 168.4 6.5 8 18 15 100.1 4.1 8 21 5 267.6 4.5 8 13 14 289.4 4.7 8 15 27 159.8 6.8 8 18 16 69.8 6.6 8 21 6 188.2 4.0 8 13 15 150.9 4.7 8 15 28 149.9 6.5 8 18 17 152.9 3.9 8 21 7 47.0 7.0 8 13 16 414.4 6.0 8 16 0 406.3 8.8 8 18 18 24.0 10.4 8 21 8 112.8 4.3 8 13 17 81.3 6.6 8 16 1 171.5 10.8 8 18 19 188.2 4.1 8 21 9 68.7 5.7 8 13 18 141.5 3.9 8 16 4 313.1 5.2 8 18 20 215.3 4.2 8 21 10 392.2 6.9 8 13 19 257.7 4.2 8 16 5 293.6 4.2 8 18 21 144.7 5.4 8 21 11 229.9 4.1 8 13 20 58.0 9.4 8 16 6 46.4 9.2 8 18 22 284.6 21.9 8 21 12 286.8 4.5 8 13 21 248.3 4.4 8 16 7 363.4 5.0 8 18 23 95.0 6.4 8 21 13 54.5 6.3 8 13 22 111.0 7.4 8 16 8 307.4 5.2 8 18 24 165.0 5.2 8 21 14 143.9 3.8 8 13 23 129.4 5.1 8 16 9 328.4 5.3 8 18 25 202.9 4.8 8 21 15 213.9 3.6 8 13 24 248.5 12.7 8 16 10 206.9 4.1 8 18 26 26.6 12.4 8 21 16 94.2 5.6 8 13 25 98.3 8.0 8 16 11 292.6 4.5 8 18 27 208.1 5.9 8 21 17 79.5 5.3 8 13 26 73.0 10.5 8 16 12 89.0 5.7 8 19 0 422.8 8.9 8 21 18 33.9 11.4 8 13 27 61.7 14.3 8 16 13 260.8 4.6 8 19 1 346.6 5.6 8 21 19 66.8 7.1 WO 99/10379 PCT/GB98/02542 -136 8 21 21 14.6 7.4 8 24 14 150.5 3.4 8 27 12 151.1 3.8 8 30 18 130.3 6.0 8 21 22 44.4 12.3 8 24 15 158.7 3.5 8 27 13 53.8 8.4 8 30 19 58.6 9.6 8 21 23 163.2 5.5 8 24 16 72.9 6.6 8 27 14 88.2 5.5 8 30 20 159.5 5.6 8 21 24 141.0 6.6 8 24 17 164.8 3.7 8 27 16 276.0 6.4 8 31 0 17.1 8.2 8 21 25 113.9 11.9 8 24 18 149.0 11.4 8 27 17 120.6 3.9 8 31 1 169.1 4.0 8 21 26 124.2 7.7 8 24 19 175.4 4.2 8 27 18 25.6 11.0 8 31 2 167.3 4.2 8 22 0 258.1 5.4 8 24 20 157.2 5.2 8 27 19 165.0 4.5 8 31 3 204.2 4.7 8 22 1 132.6 2.8 8 24 21 106.7 5.7 8 27 20 115.6 5.2 8 31 4 105.5 4.2 8 22 2 157.4 4.9 8 24 22 125.8 5.2 8 27 21 90.1 7.2 8 31 5 90.7 4.8 8 22 3 103.5 5.0 8 24 23 118.8 7.4 8 27 22 67.1 11.1 8 31 6 154.9 3.4 8 22 4 199.4 3.3 8 24 24 98.1 6.9 8 28 0 318.1 5.4 8 31 7 154.5 3.2 8 22 5 90.1 3.7 8 25 0 153.1 3.2 8 28 1 48.4 7.6 8 31 8 36.6 8.7 8 22 6 334.5 5.1 8 25 1 179.4 3.7 8 28 2 320.7 6.4 8 31 9 65.5 7.5 8 22 7 71.2 5.1 8 25 2 184.2 4.6 8 28 3 13.8 6.9 8 31 10 238.7 8.7 8 22 8 373.0 5.2 8 25 3 198.2 4.7 8 28 4 92.4 3.2 8 31 11 89.1 4.9 8 22 9 49.0 7.0 8 25 4 198.2 3.6 8 28 5 112.0 4.4 8 31 12 48.2 9.9 8 22 10 221.7 4.3 8 25 5 272.0 3.9 8 28 6 126.7 3.1 8 31 13 196.2 3.7 8 22 11 111.0 4.9 8 25 6 30.1 9.0 8 28 7 48.9 7.8 8 31 14 118.4 4.6 8 22 12 357.1 4.6 8 25 7 228.8 3.6 8 28 8 156.6 3.3 8 31 15 104.1 6.5 8 22 13 403.5 5.7 8 25 8 35.1 9.8 8 28 9 139.4 3.1 8 31 16 119.3 4.5 8 22 14 153.1 3.9 8 25 9 16.7 8.0 8 28 10 33.8 10.3 8 31 17 71.5 8.0 8 22 15 149.5 3.5 8 25 10 89.4 4.0 8 28 11 230.5 3.9 8 31 18 140.9 4.7 8 22 16 62.8 6.8 8 25 11 132.0 3.5 8 28 12 111.8 4.6 8 31 19 17.8 8.8 8 22 17 105.7 6.1 8 25 12 101.7 4.1 8 28 13 114.2 4.3 8 32 0 151.0 3.8 8 22 18 78.4 6.5 8 25 13 217.8 3.7 8 28 14 338.9 13.8 8 32 1 94.0 4.2 8 22 19 113.7 6.7 8 25 14 74.5 5.2 8 28 15 160.0 4.9 8 32 2 67.8 5.8 8 22 20 265.5 7.8 8 25 15 32.1 11.2 8 28 16 133.6 4.7 8 32 3 187.0 3.7 8 22 21 71.4 8.1 8 25 16 102.9 4.8 8 28 17 148.1 4.7 8 32 4 105.2 4.8 8 22 22 171.7 4.3 8 25 17 70.4 19.9 8 28 18 53.5 8.6 8 32 5 87.7 4.8 8 22 23 104.8 5.7 8 25 18 115.8 4.9 8 28 19 143.9 7.1 8 32 6 136.3 3.6 8 22 24 21.5 10.7 8 25 19 28.6 11.3 8 28 20 26.5 11.3 8 32 7 205.5 6.6 8 22 25 138.9 5.9 8 25 20 92.6 7.8 8 28 21 154.4 6.6 8 32 8 274.7 12.5 8 23 0 515.4 9.0 8 25 21 136.9 4.6 8 28 22 91.9 20.0 8 32 9 267.1 4.6 8 23 1 20.8 8.6 8 25 22 87.0 8.6 8 29 0 134.3 2.9 8 32 10 30.2 10.5 8 23 2 431.7 7.2 8 25 23 78.2 10.2 8 29 1 86.7 4.8 8 32 11 290.4 4.6 8 23 3 212.5 3.9 8 25 24 134.8 7.3 8 29 2 162.4 3.1 8 32 12 112.8 4.5 8 23 4 220.6 3.8 8 26 0 224.9 4.9 8 29 3 69.5 8.8 8 32 13 171.6 3.8 8 23 5 174.9 2.9 8 26 1 300.3 5.9 8 29 4 166.3 3.2 8 32 14 122.1 4.5 8 23 6 182.3 3.0 8 26 2 374.4 7.4 8 29 5 88.8 3.8 8 32 15 178.5 3.9 8 23 7 218.3 3.4 8 26 3 205.3 4.6 8 29 6 116.4 3.4 8 32 16 110.4 4.6 8 23 8 84.8 4.9 8 26 4 41.7 13.0 8 29 7 132.7 3.2 8 32 17 84.1 5.4 8 23 9 74.4 4.6 8 26 5 348.2 5.0 8 29 8 146.9 3.0 8 33 0 61.3 6.7 8 23 10 133.6 3.1 8 26 6 52.8 5.5 8 29 9 196.6 3.4 8 33 1 144.7 4.6 8 23 11 471.1 7.2 8 26 7 88.4 3.9 8 29 10 282.0 4.4 8 33 2 83.1 5.7 8 23 12 354.7 5.4 8 26 8 66.6 4.3 8 29 11 87.9 4.4 8 33 3 163.2 6.0 8 23 13 133.0 3.7 8 26 9 224.9 3.7 8 29 12 166.8 3.8 8 33 4 93.9 12.3 8 23 14 15.4 7.5 8 26 10 35.7 7.7 8 29 13 310.8 8.9 8 33 5 239.6 7.7 8 23 15 115.1 4.9 8 26 11 32.4 10.6 8 29 15 223.8 3.9 8 33 7 63.2 6.1 8 23 16 97.4 4.9 8 26 12 26.3 10.0 8 29 16 33.8 11.9 8 33 8 120.3 3.8 8 23 17 20.9 9.5 8 26 13 24.0 10.1 8 29 17 87.3 7.6 8 33 9 86.7 4.2 8 23 18 176.1 3.8 8 26 14 304.6 4.2 8 29 18 148.7 4.0 8 33 10 163.3 3.6 8 3-3 19 365.9 17.3 8 26 15 215.7 3.9 8 29 19 138.5 4.8 8 33 11 85.7 5.0 8 23 20 96.4 7.0 8 26 16 111.6 9.2 8 29 20 169.4 4.3 8 33 12 49.4 9.5 8 23 21 183.1 4.9 8 26 17 50.5 16.2 8 29 21 71.2 9.3 8 33 13 164.0 4.8 8 23 22 139.5 5.2 8 26 18 105.9 5.4 8 30 0 86.8 4.6 8 33 14 182.6 4.5 8 23 23 235.9 5.3 8 26 19 109.4 6.5 8 30 1 119.8 3.8 8 33 15 157.5 4.3 8 23 24 230.7 6.0 8 26 20 85.2 6.8 8 30 2 96.5 4.2 8 33 16 86.8 5.9 8 23 25 68.5 9.9 8 26 21 84.6 8.1 8 30 3 151.1 3.8 8 33 17 64.0 9.2 8 24 0 551.5 11.1 8 26 22 16.0 8.0 8 30 4 227.9 5.0 8 34 0 83.7 9.2 8 24 1 301.8 4.7 8 26 23 30.3 12.2 8 30 5 115.9 3.9 8 34 2 137.5 4.7 8 24 2 550.7 10.9 8 27 0 182.2 3.3 8 30 6 154.8 3.1 8 34 4 126.4 4.1 8 24 3 123.1 6.4 8 27 1 132.4 4.0 8 30 7 236.2 3.6 8 34 5 66.4 5.9 8 24 4 268.2 4.3 8 27 2 94.6 4.5 8 30 8 75.6 4.4 8 34 6 181.3 4.4 8 24 5 96.3 3.4 8 27 3 236.5 4.5 8 30 9 116.0 3.1 8 34 7 250.5 5.5 8 24 6 11.4 5.7 8 27 4 244.2 5.4 8 30 10 140.9 3.6 8 34 8 106.9 3.6 8 24 7 161.7 3.1 8 27 5 273.9 6.1 8 30 11 22.6 11.1 8 34 9 104.6 4.5 8 24 8 224.2 3.7 8 27 6 193.1 3.9 8 30 12 141.9 16.4 8 34 10 61.3 6.1 8 24 9 298.7 4.8 8 27 7 126.4 3.1 8 30 13 122.1 4.5 8 34 11 236.4 4.0 8 24 10 171.9 3.2 8 27 8 99.7 3.6 8 30 14 113.6 4.8 8 34 12 124.8 3.9 8 24 11 281.2 4.6 8 27 9 139.5 3.3 8 30 15 112.6 5.8 8 34 13 181.3 4.0 8 24 12 174.8 3.4 8 27 10 146.1 3.3 8 30 16 194.0 3.9 8 34 14 77.8 6.6 8 24 13 107.0 4.0 8 27 11 177.5 4.1 8 30 17 85.8 5.9 8 34 15 22.2 10.2 WO 99/10379 PCT/GB98/02542 -137 8 35 0 80.6 5.5 9 0 16 129.8 6.5 9 2 27 117.6 6.5 9 5 7 654.9 8.9 8 35 1 108.0 4.1 9 0 17 291.8 7.9 9 2 28 53.2 16.1 9 5 8 252.8 13.1 8 35 2 99.7 3.9 9 0 18 193.7 5.8 9 2 29 120.2 7.1 9 5 9 164.4 4.0 8 35 3 135.5 3.7 9 0 19 13.5 10.0 9 2 30 200.2 5.8 9 5 10 534.8 20.5 8 35 4 113.1 4.1 9 0 20 25.3 15.3 9 3 0 250.3 3.9 9 5 11 286.7 4.6 8 35 5 125.5 5.0 9 0 21 52.4 16.0 9 3 1 217.9 4.6 9 5 12 69.2 10.5 8 35 6 127.7 4.5 9 0 22 92.8 8.8 9 3 2 373.1 5.7 9 5 13 225.8 4.3 8 35 7 235.1 4.3 9 0 23 71.9 16.0 9 3 3 269.3 4.2 9 5 14 221.0 5.0 8 35 8 124.3 3.5 9 0 24 57.1 18.9 9 3 4 115.9 5.0 9 5 15 312.5 4.7 8 35 9 173.5 3.4 9 0 25 15.0 11.2 9 3 5 79.2 4.9 9 5 16 104.9 5.7 8 35 10 57.0 6.9 9 0 26 31.6 21.2 9 3 6 13.0 6.6 9 5 17 94.6 6.2 8 35 11 118.5 4.1 9 0 27 150.7 8.0 9 3 7 64.0 7.8 9 5 18 136.4 5.6 8 35 12 67.8 7.3 9 0 28 39.9 22.4 9 3 8 238.4 4.9 9 5 19 99.2 5.5 8 35 13 50.2 7.3 9 0 29 302.6 8.8 9 3 9 382.5 6.1 9 5 20 102.0 6.3 8 35 14 89.8 6.8 9 0 30 30.9 20.6 9 3 11 24.9 11.9 9 5 21 86.3 6.6 8 36 0 50.1 8.1 9 1 0 883.2 15.4 9 3 12 667.6 9.4 9 5 22 142.6 5.7 8 36 1 101.1 3.8 9 1 1 546.5 9.6 9 3 13 417.5 7.0 9 5 23 90.3 6.2 8 36 2 84.8 4.2 9 1 2 334.8 5.0 9 3 14 283.2 4.5 9 5 24 60.9 11.4 8 36 3 91.4 4.4 9 1 3 161.7 3.6 9 3 15 313.5 5.6 9 5 25 345.8 11.3 8 36 4 14.7 7.2 9 1 4 508.6 7.4 9 3 16 106.9 6.0 9 5 26 144.3 7.4 8 36 5 120.5 4.4 9 1 5 586.3 8.6 9 3 17 214.0 4.8 9 5 27 93.7 12.1 8 36 6 124.2 4.1 9 1 6 229.7 4.0 9 3 18 122.7 4.6 9 5 28 174.4 5.5 8 36 7 210.8 4.1 9 1 7 231.4 3.9 9 3 19 116.8 5.2 9 5 29 22.9 11.4 8 36 8 254.7 4.9 9 1 8 558.5 8.5 9 3 20 131.4 5.0 9 6 0 378.3 5.6 8 36 9 122.0 3.6 9 1 9 356.7 6.7 9 3 21 86.9 6.3 9 6 1 252.6 3.6 8 36 10 55.5 6.9 9 1 10 315.8 9.4 9 3 22 152.9 4.9 9 6 2 265.9 4.2 8 36 11 102.9 4.5 9 1 11 103.2 18.5 9 3 23 54.0 14.0 9 6 3 208.3 3.3 8 36 12 54.3 7.2 9 1 12 411.6 6.2 9 3 24 104.3 6.0 9 6 4 385.8 5.6 8 36 13 64.6 13.9 9 1 13 252.6 5.1 9 3 25 195.9 13.6 9 6 5 451.9 6.7 8 37 0 102.3 4.3 9 1 14 70.7 9.2 9 3 26 32.9 14.8 9 6 6 212.6 3.8 8 37 1 204.2 5.1 9 1 15 274.1 5.0 9 3 27 196.3 5.0 9 6 7 345.2 6.4 8 37 2 91.8 4.4 9 1 16 19.8 9.8 9 3 28 89.9 9.9 9 6 8 163.1 4.4 8 37 3 32.4 9.9 9 1 17 190.3 4.3 9 3 29 175.3 6.6 9 6 10 355.3 12.7 8 37 4 69.9 6.6 9 1 18 212.0 7.3 9 3 30 85.8 11.2 9 6 11 381.9 5.6 8 37 5 65.7 6.5 9 1 19 63.7 8.7 9 4 0 67.4 4.6 9 6 12 72.4 8.9 8 37 6 199.3 4.6 9 1 20 160.2 4.1 9 4 1 356.1 6.2 9 6 13 598.6 8.9 8 37 7 14.4 7.2 9 1 21 112.2 5.2 9 4 2 320.2 4.5 9 6 14 167.8 5.9 8 37 8 102.2 5.7 9 1 22 72.8 7.9 9 4 3 629.3 8.7 9 6 15 264.2 4.8 8 37 9 118.4 3.8 9 1 23 48.9 13.9 9 4 4 246.9 4.4 9 6 16 263.5 5.1 8 37 10 129.2 3.6 9 1 24 20.8 10.3 9 4 5 238.8 3.9 9 6 17 284.2 4.7 8 37 11 121.6 4.2 9 1 26 95.2 10.4 9 4 6 42.9 9.1 9 6 18 221.2 4.1 8 38 0 118.5 3.7 9 1 27 243.5 5.4 9 4 7 741.0 9.5 9 6 19 119.0 4.9 8 38 1 137.7 3.6 9 1 28 177.9 6.1 9 4 8 379.8 18.4 9 6 20 217.3 4.0 8 38 2 133.6 3.5 9 1 29 90.2 10.4 9 4 9 18.0 8.9 9 6 21 89.8 6.5 8 38 3 100.0 4.5 9 1 30 144.5 7.6 9 4 10 386.8 13.2 9 6 22 77.2 6.8 8 38 4 78.1 5.5 9 2 0 179.0 3.4 9 4 11 91.3 6.1 9 6 23 76.6 9.0 8 38 5 49.8 9.1 9 2 1 575.3 9.3 9 4 12 315.8 4.8 9 6 24 197.2 5.4 8 38 6 26.0 11.2 9 2 2 185.6 3.7 9 4 13 26.9 11.7 9 6 25 257.9 10.5 8 38 7 148.9 4.5 9 2 3 241.5 4.0 9 4 14 257.5 4.4 9 6 26 32.9 13.9 8 38 8 71.9 6.8 9 2 4 520.7 7.6 9 4 15 139.1 5.0 9 6 27 162.9 9.9 8 39 0 204.9 8.3 9 2 5 424.9 6.3 9 4 16 114.1 7.0 9 6 28 105.6 9.1 8 39 1 132.2 4.2 9 2 6 182.6 3.7 9 4 17 309.7 5.0 9 6 29 101.4 9.2 8 39 2 67.0 5.4 9 2 7 186.5 3.6 9 4 18 76.3 6.8 9 6 30 28.6 13.4 8 39 3 24.7 10.0 9 2 8 497.1 7.4 9 4 19 167.6 3.7 9 7 0 521.0 9.4 8 39 4 69.1 5.8 9 2 9 500.9 7.8 9 4 20 109.9 5.3 9 7 1 494.8 7.8 8 39 5 71.4 5.8 9 2 10 337.0 11.0 9 4 21 120.4 5.5 9 7 2 164.3 3.8 8 39 6 106.3 5.3 9 2 11 211.7 6.1 9 4 22 191.5 4.5 9 7 3 323.8 4.5 9 0 0 680.5 18.8 9 2 12 270.7 4.4 9 4 23 153.5 4.7 9 7 4 335.9 4.8 9 0 1 81.9 20.8 9 2 13 335.2 5.8 9 4 24 214.7 4.6 9 7 5 466.2 7.1 9 0 2 321.0 6.6 9 2 14 252.1 4.5 9 4 25 206.4 15.6 9 7 6 288.4 5.1 9 0 3 12.2 8.9 9 2 15 148.3 5.2 9 4 26 66.6 12.9 9 7 7 325.2 8.4 9 0 4 155.7 11.1 9 2 16 322.2 5.4 9 4 27 154.0 6.7 9 7 8 161.1 4.4 9 0 5 165.6 5.4 9 2 17 64.6 8.0 9 4 28 111.9 8.8 9 7 9 405.2 19.1 9 0 6 291.6 6.5 9 2 18 59.3 8.5 9 4 29 155.5 6.0 9 7 10 270.2 4.9 9 0 7 290.8 8.9 9 2 19 108.9 5.4 9 4 30 30.0 14.6 9 7 11 367.6 5.8 9 0 8 48.6 24.0 9 2 20 64.1 8.4 9 5 0 276.2 4.1 9 7 12 79.3 7.5 9 0 9 452.8 9.9 9 2 21 27.9 11.9 9 5 1 388.8 6.3 9 7 13 106.9 8.7 9 0 10 274.7 11.5 9 2 22 128.5 4.6 9 5 2 286.9 4.2 9 7 14 230.5 4.1 9 0 12 184.4 6.5 9 2 23 170.3 4.4 9 5 3 370.4 5.7 9 7 15 202.6 3.9 9 0 13 602.5 13.7 9 2 24 60.2 9.9 9 5 4 70.8 5.0 9 7 16 395.3 5.7 9 0 14 183.2 6.7 9 2 25 39.3 16.5 9 5 5 388.9 7.3 9 7 17 170.7 3.8 9 0 15 178.9 5.7 9 2 26 30.5 14.0 9 5 6 508.0 7.6 9 7 18 145.3 4.7 WO 99/10379 PCT/GB98/02542 -138 9 7 19 150.7 4.5 9 10 4 143.8 10.9 9 12 22 114.8 5.2 9 15 10 283.5 4.7 9 7 20 172.9 4.8 9 10 5 392.0 6.4 9 12 23 29.8 13.1 9 15 11 329.8 5.3 9 7 21 186.3 4.2 9 10 8 155.2 6.2 9 12 25 170.2 4.7 9 15 12 127.5 4.3 9 7 22 90.4 7.3 9 10 9 538.8 8.0 9 12 26 167.7 5.1 9 15 13 65.0 6.4 9 7 23 195.5 5.2 9 10 10 135.4 4.7 9 12 27 110.4 8.9 9 15 14 70.4 6.2 9 7 24 24.4 11.7 9 10 11 116.8 4.6 9 12 28 144.1 6.4 9 15 15 80.0 8.4 9 7 25 198.4 8.2 9 10 12 126.4 4.8 9 13 0 337.2 4.7 9 15 16 92.2 5.1 9 7 26 133.3 6.3 9 10 13 472.4 7.0 9 13 1 113.9 3.5 9 15 17 53.6 10.3 9 7 27 25.4 12.6 9 10 15 95.2 6.6 9 13 2 470.8 7.2 9 15 18 53.9 10.5 9 7 28 143.0 6.6 9 10 16 17.5 8.7 9 13 4 315.0 19.4 9 15 19 181.8 4.1 9 7 29 91.6 9.5 9 10 17 193.9 4.4 9 13 5 129.8 5.0 9 15 20 119.0 5.1 9 8 0 317.2 6.7 9 10 18 218.8 4.1 9 13 6 478.4 8.3 9 15 21 212.8 4.2 9 8 1 468.3 8.1 9 10 19 223.2 4.3 9 13 7 342.1 5.1 9 15 22 63.1 15.2 9 8 2 138.0 3.8 9 10 20 165.9 4.4 9 13 8 563.2 8.8 9 15 23 118.8 7.6 9 8 3 461.4 7.0 9 10 21 140.5 4.7 9 13 9 356.9 5.6 9 15 24 64.2 12.2 9 8 4 365.4 5.4 9 10 22 35.2 15.4 9 13 10 312.9 6.0 9 15 25 86.3 7.6 9 8 5 527.0 7.7 9 10 23 181.3 4.3 9 13 11 595.4 8.6 9 15 26 185.3 5.8 9 8 6 501.1 7.9 9 10 24 229.5 15.8 9 13 12 301.4 5.1 9 15 27 99.0 10.1 9 8 7 302.2 4.8 9 10 25 156.6 6.3 9 13 13 193.2 3.8 9 15 28 108.3 9.2 9 8 10 690.3 9.9 9 10 26 109.3 8.8 9 13 14 86.4 5.9 9 16 0 74.3 5.9 9 8 11 161.9 4.6 9 10 27 135.8 8.2 9 13 15 128.6 3.8 9 16 1 387.0 6.8 9 8 12 254.8 4.5 9 10 28 113.8 8.2 9 13 16 38.1 12.3 9 16 2 332.2 4.9 9 8 13 20.7 10.2 9 10 29 210.1 5.6 9 13 17 124.9 4.2 9 16 3 294.3 7.0 9 8 14 174.6 4.1 9 11 0 85.8 4.2 9 13 18 108.3 6.0 9 16 4 232.6 4.1 9 8 15 260.2 4.5 9 11 1 121.2 4.0 9 13 19 154.6 3.9 9 16 5 214.7 3.7 9 8 16 230.6 4.6 9 11 2 396.4 7.1 9 13 20 131.1 5.2 9 16 6 257.2 4.5 9 8 17 205.9 5.2 9 11 3 404.0 5.8 9 13 21 48.6 14.9 9 16 7 375.8 7.2 9 8 18 36.5 11.9 9 11 4 99.8 5.0 9 13 22 144.9 4.9 9 16 8 184.2 4.1 9 8 19 171.7 3.8 9 11 5 173.4 3.7 9 13 23 200.6 13.6 9 16 9 200.9 4.4 9 8 20 121.1 4.3 9 11 7 27.5 13.3 9 13 24 68.5 10.1 9 16 10 103.9 4.8 9 8 21 126.8 5.0 9 11 8 114.2 5.3 9 13 25 47.0 13.1 9 16 11 163.0 4.7 9 8 22 160.6 4.3 9 11 9 421.4 6.5 9 13 26 75.5 11.2 9 16 12 273.3 4.5 9 8 23 63.2 13.8 9 11 10 432.0 6.5 9 13 27 74.5 12.3 9 16 13 18.6 8.8 9 8 24 18.1 9.0 9 11 11 307.1 5.3 9 13 28 54.2 14.6 9 16 14 135.5 4.3 9 8 25 178.5 5.7 9 11 12 268.9 4.8 9 14 0 383.1 13.6 9 16 15 197.3 3.7 9 8 26 21.1 10.6 9 11 13 75.0 6.5 9 14 1 342.4 13.7 9 16 16 241.8 4.0 9 8 27 56.7 14.0 9 11 14 219.0 4.1 9 14 2 267.3 7.9 9 16 17 210.3 3.9 9 8 28 96.1 11.7 9 11 15 254.7 4.2 9 14 3 485.8 12.5 9 16 18 160.1 4.2 9 8 29 135.9 7.2 9 11 16 156.4 4.1 9 14 4 270.0 4.4 9 16 19 135.2 4.2 9 9 0 260.2 5.3 9 11 17 179.1 3.9 9 14 5 351.7 5.3 9 16 20 181.3 5.1 9 9 1 553.0 9.9 9 11 18 74.6 6.8 9 14 6 102.4 4.5 9 16 21 118.7 6.6 9 9 2 196.5 4.2 9 11 19 236.3 4.6 9 14 7 190.1 4.2 9 16 22 359.4 9.3 9 9 3 186.7 3.4 9 11 20 161.5 4.4 9 14 8 819.5 12.2 9 16 23 143.4 5.4 9 9 4 629.8 8.3 9 11 21 79.2 8.2 9 14 9 37.5 10.9 9 16 24 58.6 11.1 9 9 5 118.3 7.6 9 11 22 159.0 5.3 9 14 10 215.9 4.4 9 16 25 59.8 15.3 9 9 6 372.4 6.8 9 11 23 131.2 5.0 9 14 11 444.5 7.1 9 16 26 137.9 9.0 9 9 8 472.4 17.6 9 11 24 531.6 47.8 9 14 12 200.6 4.0 9 16 27 74.4 11.6 9 9 9 368.7 7.0 9 11 25 86.1 11.0 9 14 13 284.8 4.6 9 17 0 322.3 6.1 9 9 10 347.7 5.4 9 11 26 137.3 5.5 9 14 14 142.0 3.7 9 17 1 280.3 5.5 9 9 11 389.2 5.8 9 11 27 26.5 13.2 9 14 15 127.4 3.8 9 17 2 302.1 4.8 9 9 12 200.0 4.9 9 11 28 46.3 14.9 9 14 16 87.1 5.4 9 17 3 334.5 6.4 9 J9 13 350.3 5.8 9 11 29 21.3 10.7 9 14 17 81.6 5.7 9 17 4 145.2 4.2 9 9 14 159.7 6.2 9 12 0 286.2 6.5 9 14 18 85.8 5.7 9 17 5 168.3 3.2 9 9 .15 104.1 6.2 9 12 1 462.9 8.3 9 14 19 108.1 6.0 9 17 6 254.4 3.9 9 9 16 188.9 3.6 9 12 2 255.7 7.3 9 14 20 197.6 4.1 9 17 7 149.6 4.0 9 9 17 127.3 4.5 9 12 3 17.3 8.2 9 14 21 81.1 7.9 9 17 8 200.6 3.7 9 9 18 140.7 4.0 9 12 4 243.1 4.0 9 14 22 119.9 5.3 9 17 9 145.4 4.1 9 9 19 149.6 4.1 9 12 7 232.5 3.9 9 14 23 244.1 11.9 9 17 10 149.0 3.8 9 9 20 74.7 7.4 9 12 8 201.3 4.0 9 14 25 57.3 14.2 9 17 11 348.2 6.6 9 9 21 152.3 4.3 9 12 9 226.8 4.5 9 14 26 185.1 5.7 9 17 12 132.6 4.4 9 9 22 17.0 8.6 9 12 10 337.5 5.5 9 14 27 134.3 10.5 9 17 13 161.2 3.8 9 9 23 110.0 6.2 9 12 11 334.9 5.2 9 14 28 49.0 16.4 9 17 14 56.7 7.4 9 9 24 102.9 8.7 9 12 12 18.8 8.8 9 15 0 257.7 4.5 9 17 15 224.2 4.3 9 9 25 69.0 13.8 9 12 13 368.5 6.0 9 15 1 182.2 3.8 9 17 16 40.7 11.8 9 9 26 112.1 8.9 9 12 14 263.1 4.5 9 15 2 209.3 5.5 9 17 17 48.0 10.8 9 9 27 67.5 14.2 9 12 15 307.5 4.3 9 15 3 176.1 4.2 9 17 18 55.7 7.5 9 9 28 22.5 11.1 9 12 16 47.1 13.3 9 15 4 68.9 7.7 9 17 19 34.3 12.5 9 9 29 38.5 14.6 9 12 17 107.8 5.8 9 15 5 297.8 5.3 9 17 20 194.1 3.9 9 10 0 583.7 8.6 9 12 18 115.5 4.7 9 15 6 506.2 6.9 9 17 21 27.9 13.0 9 10 1 289.9 4.4 9 12 19 155.4 5.4 9 15 7 312.2 4.7 9 17 22 151.6 4.9 9 10 2 271.5 4.1 9 12 20 232.1 4.1 9 15 8 109.5 4.7 9 17 23 167.5 4.6 9 10 3 375.5 5.4 9 12 21 171.7 4.9 9 15 9 378.1 5.8 9 17 24 101.5 9.0 WO 99/10379 PCT/GB98/02542 -139 9 17 25 188.3 5.7 9 20 15 97.3 4.5 9 23 11 162.2 3.9 9 26 11 18.2 8.4 9 17 26 20.0 9.7 9 20 16 72.3 7.0 9 23 12 287.0 5.2 9 26 12 87.9 6.4 9 17 27 18.7 9.4 9 20 17 64.6 8.8 9 23 13 90.6 5.1 9 26 13 85.7 8.9 9 18 0 86.8 4.4 9 20 18 78.8 6.8 9 23 14 125.0 4.5 9 26 14 136.4 3.8 9 18 1 256.8 4.7 9 20 19 57.8 8.6 9 23 15 162.1 3.7 9 26 15 227.5 14.1 9 18 2 101.7 5.7 9 20 20 348.5 11.8 9 23 16 133.6 4.7 9 26 16 64.4 10.0 9 18 3 219.2 5.0 9 20 21 46.0 11.9 9 23 17 26.7 11.8 9 26 17 154.5 5.1 9 18 4 79.0 4.3 9 20 22 157.8 4.8 9 23 18 240.2 11.7 9 26 18 169.1 6.6 9 18 5 438.7 6.5 9 20 23 81.2 7.8 9 23 19 197.5 4.3 9 26 19 52.8 12.0 9 18 6 98.9 4.9 9 20 24 75.0 9.8 9 23 21 111.6 7.6 9 26 20 26.3 11.2 9 18 7 324.6 4.8 9 20 25 24.1 11.5 9 23 22 155.6 5.6 9 26 21 124.7 5.0 9 18 8 76.6 5.2 9 20 26 89.4 12.5 9 23 23 130.6 5.8 9 26 22 83.6 6.4 9 18 9 264.5 4.4 9 21 0 179.2 3.0 9 23 24 30.5 13.0 9 27 0 123.8 4.3 9 18 10 129.3 4.0 9 21 1 120.2 7.3 9 24 0 355.4 9.0 9 27 1 128.2 4.1 9 18 11 143.8 4.3 9 21 2 343.2 5.5 9 24 1 265.6 4.5 9 27 2 135.6 3.1 9 18 12 123.1 3.8 9 21 3 219.2 3.6 9 24 2 296.0 5.2 9 27 3 109.0 3.8 9 18 13 114.1 4.0 9 21 4 424.1 5.8 9 24 3 117.2 4.3 9 27 4 166.3 4.1 9 18 14 211.3 3.7 9 21 5 287.1 4.7 9 24 4 25.2 9.5 9 27 5 214.3 3.7 9 18 15 50.4 8.2 9 21 6 205.9 3.3 9 24 5 116.3 3.3 9 27 6 236.4 3.7 9 18 16 139.0 3.7 9 21 7 126.4 4.1 9 24 6 15.1 7.2 9 27 7 138.3 3.2 9 18 17 49.0 11.6 9 21 8 154.4 3.5 9 24 7 19.2 8.5 9 27 8 70.6 6.2 9 18 18 206.3 4.6 9 21 9 398.4 5.4 9 24 8 67.6 5.1 9 27 9 206.0 3.5 9 18 19 216.5 4.1 9 21 10 263.1 4.4 9 24 9 192.7 3.2 9 27 10 125.4 3.7 9 18 20 92.5 5.9 9 21 11 366.1 5.2 9 24 10 153.4 3.3 9 27 11 35.0 9.0 9 18 21 413.7 17.6 9 21 12 39.4 10.8 9 24 11 148.7 3.7 9 27 12 83.9 4.9 9 18 22 83.1 7.0 9 21 13 127.3 4.2 9 24 12 166.9 3.8 9 27 14 276.6 13.2 9 18 23 71.2 12.9 9 21 14 150.5 3.7 9 24 13 37.3 10.6 9 27 15 100.7 6.1 9 18 24 134.1 7.6 9 21 15 75.5 8.2 9 24 14 181.6 3.8 9 27 16 267.1 4.6 9 18 25 23.4 11.2 9 21 16 121.6 4.5 9 24 15 63.2 7.4 9 27 17 87.4 6.5 9 18 26 18.0 8.9 9 21 17 52.7 12.3 9 24 16 193.2 4.2 9 27 18 80.1 7.8 9 19 0 139.9 4.7 9 21 18 61.3 7.9 9 24 17 369.7 14.8 9 27 19 98.6 6.4 9 19 1 192.7 3.7 9 21 19 160.5 15.1 9 24 18 229.8 4.1 9 27 20 27.1 11.7 9 19 2 228.5 3.6 9 21 20 183.4 4.9 9 24 19 38.3 13.4 9 27 21 103.3 6.9 9 19 3 91.3 4.0 9 21 21 163.3 5.7 9 24 20 91.6 8.3 9 28 0 170.3 4.4 9 19 4 317.1 4.4 9 21 22 205.2 4.7 9 24 21 84.9 6.6 9 28 1 211.0 3.5 9 19 5 46.0 9.3 9 21 23 174.1 7.2 9 24 22 54.0 11.7 9 28 2 152.8 4.1 9 19 6 234.5 4.0 9 21 24 83.8 9.4 9 24 23 99.6 6.4 9 28 3 152.3 3.3 9 19 7 69.0 5.2 9 21 25 110.4 7.3 9 25 0 141.1 4.2 9 28 4 59.4 8.2 9 19 8 85.3 5.7 9 22 0 228.6 4.2 9 25 1 197.1 3.9 9 28 5 61.9 4.7 9 19 9 120.4 3.7 9 22 1 349.8 5.2 9 25 2 107.1 5.2 9 28 6 68.2 5.2 9 19 10 228.4 3.6 9 22 2 49.9 5.3 9 25 3 204.7 3.7 9 28 7 188.5 3.4 9 19 11 109.7 4.7 9 22 3 504.0 10.5 9 25 4 136.8 5.9 9 28 8 98.5 3.9 9 19 12 127.2 3.7 9 22 4 201.3 3.9 9 25 5 186.9 3.6 9 28 9 155.9 5.0 9 19 13 131.9 3.7 9 22 5 389.9 5.9 9 25 6 82.5 4.8 9 28 10 98.8 4.7 9 19 14 181.7 3.6 9 22 6 206.9 3.9 9 25 7 66.2 5.1 9 28 11 135.6 3.7 9 19 15 270.8 4.2 9 22 7 327.6 5.9 9 25 8 121.5 3.4 9 28 12 81.8 7.2 9 19 16 168.5 4.1 9 22 8 103.8 3.5 9 25 9 68.6 6.7 9 28 13 184.1 24.7 9 19 17 78.8 6.3 9 22 9 136.9 3.2 9 25 10 209.4 3.6 9 28 14 141.2 4.0 9 19 18 279.1 4.6 9 22 10 55.0 7.5 9 25 11 37.2 9.2 9 28 15 60.9 8.6 9 19 19 95.2 9.4 9 22 11 247.4 4.2 9 25 12 70.5 5.8 9 28 16 231.0 4.5 9 19 20 19.6 9.7 9 22 12 265.5 4.1 9 25 13 160.0 3.7 9 28 17 55.6 10.6 9 1.9 21 155.1 7.6 9 22 13 62.3 7.6 9 25 14 228.7 3.7 9 28 18 65.0 7.8 9 19 22 180.3 6.3 9 22 14 224.3 3.9 9 25 15 214.0 4.0 9 28 19 39.7 15.8 9 19 23 127.5 6.5 9 22 15 148.3 3.7 9 25 16 268.2 10.5 9 28 20 66.1 8.5 9 19 24 62.4 10.3 9 22 16 99.6 5.8 9 25 17 229.6 4.2 9 29 0 140.5 4.2 9 19 25 210.3 5.0 9 22 17 163.8 4.3 9 25 18 132.2 6.5 9 29 1 116.1 5.9 9 19 26 159.4 6.2 9 22 19 131.7 7.2 9 25 19 210.2 4.2 9 29 2 187.4 4.3 9 20 0 276.8 5.3 9 22 20 23.8 10.9 9 25 20 103.3 6.2 9 29 3 133.3 3.5 9 20 1 217.1 3.7 9 22 21 101.0 6.1 9 25 21 55.2 11.9 9 29 4 210.4 4.5 9 20 2 159.4 4.7 9 22 23 73.5 9.5 9 25 22 49.9 15.1 9 29 5 198.2 4.6 9 20 3 179.5 3.6 9 22 24 109.0 7.8 9 25 23 89.4 11.8 9 29 6 166.4 4.0 9 20 4 131.8 3.8 9 23 0 632.6 11.1 9 26 0 250.2 4.5 9 29 7 116.6 3.5 9 20 5 199.4 3.3 9 23 1 230.7 3.9 9 26 1 134.0 3.2 9 29 8 223.1 3.7 9 20 6 64.5 5.6 9 23 2 397.9 6.7 9 26 2 132.3 3.9 9 29 9 104.3 3.5 9 20 7 227.7 4.6 9 23 3 413.7 7.9 9 26 3 182.0 3.5 9 29 10 219.5 3.5 9 20 8 66.3 7.4 9 23 4 209.1 3.2 9 26 4 160.5 4.2 9 29 11 192.6 12.4 9 20 9 138.5 3.5 9 23 5 129.5 4.1 9 26 5 66.3 6.0 9 29 12 39.3 13.2 9 20 10 134.3 3.6 9 23 6 156.7 3.1 9 26 6 173.5 3.2 9 29 13 187.7 3.8 9 20 11 16.8 8.1 9 23 7 173.1 4.0 9 26 7 134.1 3.6 9 29 14 110.8 5.9 9 20 12 121.1 3.8 9 23 8 93.7 4.2 9 26 8 134.9 3.6 9 29 15 146.0 5.5 9 20 13 112.1 3.9 9 23 9 60.1 5.7 9 26 9 104.0 4.2 9 29 16 69.2 8.5 9 20 14 125.1 3.6 9 23 10 173.5 3.5 9 26 10 131.0 3.6 9 29 17 131.7 5.8 WO 99/10379 PCT/GB98/02542 -140 9 29 18 59.2 12.9 9 33 13 155.3 4.9 10 0 11 276.3 7.1 10 2 23 73.1 9.1 9 29 19 123.0 5.1 9 33 14 124.5 4.9 10 0 12 247.4 6.3 10 2 24 128.2 35.5 9 29 20 121.2 6.4 9 33 15 105.3 4.6 10 0 13 17.4 12.3 10 2 25 159.6 6.0 9 30 0 176.1 3.5 9 34 0 106.6 4.5 10 0 14 84.5 19.2 10 2 26 126.7 9.3 9 30 1 172.7 4.5 9 34 1 71.1 6.3 10 0 15 147.9 6.8 10 2 27 157.0 6.6 9 30 2 132.5 3.9 9 34 2 248.5 5.1 10 0 16 105.8 12.4 10 2 28 199.9 5.7 9 30 3 168.0 4.8 9 34 3 125.1 4.7 10 0 17 84.8 19.8 10 2 29 74.3 11.4 9 30 4 96.6 4.7 9 34 4 47.4 13.0 10 0 18 158.9 5.8 10 3 0 384.8 5.6 9 30 5 152.2 4.4 9 34 5 88.8 6.0 10 0 19 187.7 6.0 10 3 1 244.8 4.0 9 30 6 38.0 9.3 9 34 6 24.3 10.8 10 0 20 193.3 6.2 10 3 2 403.0 6.8 9 30 7 172.9 3.3 9 34 7 32.4 11.1 10 0 21 260.2 6.6 10 3 3 344.0 6.4 9 30 8 187.6 3.6 9 34 8 219.8 3.8 10 0 22 32.5 17.1 10 3 4 384.4 6.0 9 30 9 69.6 16.6 9 34 9 19.7 9.1 10 0 23 164.6 7.0 10 3 5 373.9 22.8 9 30 10 261.2 15.8 9 34 10 85.3 5.6 10 0 24 35.8 23.9 10 3 6 513.2 9.4 9 30 11 72.8 7.1 9 34 11 185.5 3.8 10 0 25 32.7 19.3 10 3 7 278.0 9.2 9 30 12 98.7 4.3 9 34 12 61.8 9.3 10 0 26 60.4 23.1 10 3 8 644.6 22.0 9 30 13 22.7 10.5 9 34 13 56.0 9.1 10 0 27 251.1 7.7 10 3 9 369.9 5.9 9 30 14 111.1 6.5 9 34 14 106.5 4.9 10 0 28 22.3 15.6 10 3 10 203.7 5.0 9 30 15 112.6 6.1 9 35 0 94.9 7.1 10 0 29 137.4 14.5 10 3 11 437.8 6.5 9 30 16 101.8 4.8 9 35 1 188.2 4.9 10 1 0 496.7 7.1 10 3 12 189.5 4.4 9 30 17 191.1 4.1 9 35 2 83.4 7.5 10 1 1 584.0 8.9 10 3 13 211.6 4.8 9 30 18 140.5 8.6 9 35 3 59.0 7.2 10 1 2 505.2 6.7 10 3 14 228.0 4.4 9 30 19 61.3 10.0 9 35 4 43.9 10.3 10 1 3 94.5 4.5 10 3 15 189.0 4.2 9 31 0 23.7 9.7 9 35 5 46.3 10.6 10 1 4 347.3 4.9 10 3 16 290.8 4.8 9 31 1 35.5 11.1 9 35 6 197.0 4.9 10 1 5 16.5 8.3 10 3 17 183.9 6.4 9 31 2 101.9 5.1 9 35 7 66.5 7.0 10 1 6 166.0 10.3 10 3 18 167.7 4.2 9 31 3 66.8 4.4 9 35 8 215.3 4.2 10 1 7 495.7 7.5 10 3 19 222.0 4.7 9 31 4 297.5 7.5 9 35 9 149.5 3.5 10 1 8 549.9 12.4 10 3 20 48.9 12.1 9 31 5 56.5 5.8 9 35 10 56.7 7.5 10 1 9 368.2 8.2 10 3 21 132.1 5.0 9 31 6 105.8 7.8 9 35 11 69.4 9.6 10 1 10 26.3 12.7 10 3 22 208.9 4.6 9 31 7 92.7 20.5 9 35 12 107.8 4.9 10 1 11 204.2 5.0 10 3 23 77.2 9.0 9 31 9 157.9 4.4 9 35 13 168.2 7.8 10 1 12 127.3 4.8 10 3 24 140.8 16.0 9 31 10 43.0 8.3 9 36 0 161.3 4.6 10 1 13 214.3 4.6 10 3 25 195.6 4.9 9 31 11 212.8 4.5 9 36 1 103.5 4.6 10 1 14 17.7 8.9 10 3 26 135.5 7.6 9 31 12 176.7 3.9 9 36 2 130.9 4.1 10 1 15 260.2 4.4 10 3 27 226.5 5.4 9 31 13 231.8 4.1 9 36 3 158.9 4.0 10 1 16 157.8 4.9 10 3 28 134.1 7.6 9 31 14 18.6 9.0 9 36 4 104.1 5.2 10 1 17 102.1 6.8 10 3 29 113.8 7.5 9 31 15 87.1 5.9 9 36 5 96.3 5.4 10 1 18 147.9 4.7 10 4 0 23.8 10.1 9 31 16 44.8 12.3 9 36 6 137.4 4.9 10 1 19 63.2 8.7 10 4 1 307.6 4.7 9 31 17 106.8 4.4 9 36 7 123.4 4.8 10 1 20 82.3 7.9 10 4 2 19.0 8.9 9 31 18 49.8 13.4 9 36 8 77.8 7.0 10 1 21 71.0 8.1 10 4 3 196.1 3.7 9 32 0 22.0 10.0 9 36 9 90.2 7.0 10 1 22 98.8 5.8 10 4 4 671.7 9.6 9 32 1 122.9 5.1 9 36 10 82.4 5.2 10 1 23 142.7 5.4 10 4 5 383.4 7.1 9 32 2 76.4 6.7 9 36 11 152.8 4.6 10 1 24 29.4 14.7 10 4 6 199.2 4.1 9 32 3 128.2 8.8 9 37 0 40.0 10.8 10 1 25 118.7 6.7 10 4 9 210.0 4.9 9 32 4 212.6 16.7 9 37 1 45.6 9.5 10 1 26 64.0 14.6 10 4 10 164.2 6.7 9 32 5 276.6 12.7 9 37 2 83.4 5.7 10 1 27 140.7 10.4 10 4 11 235.0 4.5 9 32 6 226.2 6.2 9 37 3 181.7 4.1 10 1 28 182.8 7.0 10 4 12 372.7 6.3 9 32 7 176.1 3.9 9 37 4 86.5 5.3 10 1 29 82.2 13.3 10 4 13 47.5 12.2 9 32 8 95.7 4.1 9 37 5 19.7 8.9 10 2 0 190.1 3.6 10 4 14 25.3 11.5 9 32 9 124.1 3.9 9 37 6 18.0 8.7 10 2 1 264.6 4.0 10 4 15 174.8 4.2 9 32 10 106.7 5.1 9 37 7 96.8 5.6 10 2 2 821.1 13.0 10 4 16 245.6 4.9 9 32 11 216.2 4.5 9 37 8 108.6 4.3 10 2 3 351.1 5.7 10 4 17 264.9 4.7 9 32 12 167.7 4.1 9 37 9 126.1 5.8 10 2 4 330.3 5.0 10 4 18 97.7 6.5 9 32 13 195.8 4.0 9 38 0 197.7 4.6 10 2 5 343.2 7.0 10 4 19 106.6 5.8 9 32 14 112.5 5.3 9 38 1 218.2 5.0 10 2 6 476.3 7.8 10 4 20 171.3 4.2 9 32 15 221.1 4.5 9 38 2 102.6 4.7 10 2 7 181.0 4.1 10 4 21 94.9 8.1 9 32 16 90.4 6.5 9 38 3 163.3 5.2 10 2 8 347.9 11.5 10 4 22 130.8 5.0 9 32 17 81.1 7.4 9 38 4 136.2 4.5 10 2 9 165.8 4.6 10 4 23 100.9 9.0 9 33 0 161.9 9.0 9 38 5 64.2 9.9 10 2 10 223.1 5.1 10 4 24 270.0 12.9 9 33 1 34.5 10.9 9 38 6 172.0 8.1 10 2 11 606.4 8.4 10 4 25 131.1 7.4 9 33 2 33.7 11.9 9 39 0 28.0 12.0 10 2 12 154.0 4.1 10 4 26 168.8 7.9 9 33 3 113.3 4.8 10 0 0 11.9 8.8 10 2 13 196.1 4.3 10 4 27 162.3 7.4 9 33 4 162.3 4.0 10 0 1 16.9 11.5 10 2 14 121.8 5.5 10 4 28 118.7 9.6 9 33 5 57.8 5.1 10 0 2 538.1 10.4 10 2 15 72.7 9.0 10 4 29 121.5 9.0 9 33 6 127.3 4.7 10 0 3 90.7 10.2 10 2 16 185.4 4.3 10 5 0 173.0 3.7 9 33 7 183.7 3.2 10 0 4 807.9 14.6 10 2 17 89.1 10.0 10 5 1 402.2 6.7 9 33 8 137.0 3.8 10 0 5 57.8 18.8 10 2 18 165.9 4.1 10 5 2 402.5 7.9 9 33 9 146.3 3.4 10 0 6 402.9 9.0 10 2 19 147.8 4.0 10 5 3 236.3 4.8 9 33 10 114.7 4.5 10 0 7 178.6 6.6 10 2 20 107.3 5.5 10 5 4 110.6 10.1 9 33 11 214.5 4.0 10 0 9 44.0 19.9 10 2 21 165.5 4.1 10 5 5 282.2 6.6 9 33 12 69.7 7.4 10 0 10 103.5 16.7 10 2 22 47.3 11.5 10 5 6 118.4 5.7 WO 99/10379 PCT/GB98/02542 -141 10 5 7 531.9 15.3 10 7 21 205.5 4.3 10 10 10 418.1 8.1 10 12 25 108.3 8.6 10 5 8 337.2 5.7 10 7 22 86.4 6.5 10 10 11 103.6 5.1 10 12 26 71.5 11.3 10 5 9 216.2 4.6 10 7 23 122.6 5.5 10 10 12 335.5 5.7 10 12 27 45.1 15.2 10 5 10 315.1 6.0 10 7 24 42.5 19.9 10 10 13 199.9 4.5 10 12 28 56.9 24.4 10 5 11 215.0 4.1 10 7 25 130.1 6.4 10 10 14 193.6 3.9 10 13 0 407.7 6.6 10 5 12 106.8 5.6 10 7 26 131.6 7.1 10 10 15 237.7 5.2 10 13 1 209.0 4.6 10 5 13 267.7 4.6 10 7 27 117.3 9.2 10 10 16 20.0 9.9 10 13 2 173.8 3.8 10 5 14 231.1 4.5 10 7 28 160.9 6.1 10 10 17 61.8 7.2 10 13 3 157.9 5.0 10 5 15 350.1 5.5 10 7 29 225.1 5.7 10 10 18 135.7 4.6 10 13 4 252.1 4.2 10 5 16 359.8 5.5 10 8 0 391.0 5.8 10 10 19 165.1 4.6 10 13 5 91.6 5.6 10 5 17 165.9 4.2 10 8 1 464.2 7.2 10 10 20 44.6 12.2 10 13 6 484.6 7.1 10 5 18 64.3 8.5 10 8 2 188.7 5.4 10 10 21 158.9 5.2 10 13 7 377.5 5.5 10 5 19 111.3 6.6 10 8 3 17.4 8.8 10 10 22 119.3 5.6 10 13 8 144.6 4.8 10 5 20 221.0 4.4 10 8 4 38.4 11.7 10 10 23 424.5 12.1 10 13 9 368.0 5.8 10 5 21 32.7 12.6 10 8 7 282.4 4.6 10 10 24 161.2 5.8 10 13 10 86.4 5.5 10 5 22 92.8 8.2 10 8 8 209.3 5.4 10 10 25 28.3 13.7 10 13 11 272.7 4.3 10 5 23 60.9 9.6 10 8 9 281.6 4.8 10 10 26 97.5 11.2 10 13 12 86.2 7.1 10 5 24 448.6 11.8 10 8 10 141.0 4.2 10 10 27 22.4 10.9 10 13 13 244.8 4.5 10 5 25 25.5 12.0 10 8 12 317.3 4.9 10 10 28 118.5 10.1 10 13 14 136.1 4.1 10 5 26 135.2 6.8 10 8 13 250.9 4.4 10 11 0 358.7 11.2 10 13 15 209.0 3.8 10 5 27 178.0 6.0 10 8 14 288.9 4.6 10 11 1 545.4 22.0 10 13 16 178.4 4.4 10 5 28 163.4 6.8 10 8 15 178.4 4.1 10 11 2 585.0 17.7 10 13 17 97.5 5.6 10 5 29 44.7 17.8 10 8 16 211.9 4.1 10 11 4 351.6 5.3 10 13 18 111.7 5.0 10 6 0 166.5 3.3 10 8 17 26.7 12.5 10 11 5 64.8 8.5 10 13 19 88.8 6.0 10 6 1 188.3 3.3 10 8 18 114.3 7.1 10 11 6 125.9 5.0 10 13 20 45.7 12.3 10 6 2 294.5 5.5 10 8 19 168.1 3.8 10 11 7 340.3 5.8 10 13 21 19.4 9.6 10 6 3 232.5 5.3 10 8 20 84.0 6.4 10 11 8 166.2 4.5 10 13 22 305.6 13.2 10 6 4 593.5 7.9 10 8 21 63.1 9.6 10 11 9 107.3 5.2 10 13 23 96.2 10.1 10 6 5 45.4 13.2 10 8 22 86.3 6.3 10 11 10 102.1 6.0 10 13 24 220.1 5.3 10 6 8 272.9 4.9 10 8 23 20.8 10.4 10 11 11 251.7 4.4 10 13 25 117.8 6.8 10 6 9 223.6 4.6 10 8 25 21.9 10.6 10 11 12 265.0 4.5 10 13 26 150.7 7.5 10 6 10 75.8 10.4 10 8 26 200.2 6.4 10 11 13 192.6 4.0 10 13 27 114.0 7.9 10 6 11 52.7 10.6 10 8 27 38.6 15.7 10 11 14 132.7 5.0 10 14 0 399.1 8.2 10 6 12 407.0 6.3 10 8 28 152.3 6.1 10 11 15 145.5 3.9 10 14 1 176.5 3.6 10 6 13 210.6 4.9 10 9 0 519.6 7.9 10 11 16 171.3 4.2 10 14 2 264.8 4.1 10 6 14 338.1 5.6 10 9 1 314.9 6.3 10 11 17 63.3 8.0 10 14 3 450.7 8.1 10 6 15 119.7 4.8 10 9 2 74.3 6.2 10 11 18 108.5 5.3 10 14 4 318.0 5.0 10 6 16 125.0 7.7 10 9 3 96.5 6.9 10 11 19 150.6 5.2 10 14 5 90.5 6.4 10 6 17 206.7 4.3 10 9 4 460.7 23.8 10 11 20 201.6 4.3 10 14 6 186.2 3.8 10 6 18 105.8 4.8 10 9 5 253.2 24.8 10 11 21 193.6 4.3 10 14 7 219.5 5.0 10 6 19 106.9 5.9 10 9 6 428.6 6.1 10 11 22 127.6 6.5 10 14 8 489.6 7.4 10 6 20 178.4 5.0 10 9 7 354.7 5.2 10 11 23 246.6 25.1 10 14 9 135.5 4.5 10 6 21 84.0 8.2 10 9 8 205.6 4.7 10 11 24 76.3 9.7 10 14 10 226.2 4.0 10 6 22 222.6 4.6 10 9 9 184.0 6.2 10 11 25 195.1 6.3 10 14 11 179.8 4.1 10 6 23 106.4 5.8 10 9 10 179.8 4.1 10 11 26 148.0 6.3 10 14 12 157.1 4.4 10 6 24 367.4 12.4 10 9 11 237.8 5.0 10 11 27 138.2 8.0 10 14 13 22.6 10.2 10 6 25 254.8 6.2 10 9 12 350.6 5.4 10 11 28 20.6 10.4 10 14 14 73.2 6.2 10 6 26 195.1 6.1 10 9 13 26.7 11.3 10 12 0 18.5 8.7 10 14 15 75.5 10.5 10 6 27 147.8 10.6 10 9 14 158.0 4.8 10 12 1 119.4 4.6 10 14 17 69.1 10.8 10 6 28 97.1 12.8 10 9 15 208.1 4.3 10 12 2 19.4 9.0 10 14 18 159.4 4.1 10 6 29 59.7 18.0 10 9 16 84.9 7.1 10 12 3 217.8 4.0 10 14 19 93.1 5.5 10 .7 0 164.4 7.5 10 9 17 98.8 5.4 10 12 4 220.4 4.3 10 14 20 81.1 7.5 10 7 1 164.0 4.5 10 9 18 129.0 5.3 10 12 5 288.7 5.4 10 14 21 94.9 6.2 10 7 2 354.5 7.2 10 9 19 16.3 8.2 10 12 6 61.3 6.5 10 14 22 151.0 23.7 10 7 3 240.6 5.6 10 9 20 111.6 4.9 10 12 7 503.2 7.5 10 14 23 92.4 7.8 10 7 4 36.4 11.2 10 9 21 78.9 10.5 10 12 8 96.5 5.0 10 14 24 40.0 14.8 10 7 5 239.0 4.2 10 9 22 136.8 5.2 10 12 9 181.8 3.9 10 14 25 87.7 8.5 10 7 6 286.5 14.2 10 9 23 30.8 15.6 10 12 10 105.1 5.7 10 14 26 184.6 6.4 10 7 7 91.7 9.2 10 9 24 99.6 8.4 10 12 11 198.6 4.2 10 14 27 26.0 12.3 10 7 8 521.8 8.4 10 9 25 117.6 6.5 10 12 12 325.2 4.8 10 15 0 38.3 8.9 10 7 9 251.7 4.6 10 9 26 38.4 16.4 10 12 13 142.2 3.9 10 15 1 170.2 4.8 10 7 10 260.7 5.7 10 9 27 26.1 12.5 10 12 14 190.7 4.0 10 15 2 275.8 4.3 10 7 11 372.0 5.4 10 9 28 34.3 14.5 10 12 15 34.1 11.4 10 15 3 223.8 3.9 10 7 12 197.4 4.3 10 10 0 123.6 6.5 10 12 16 200.1 4.3 10 15 4 254.9 4.6 10 7 13 521.3 7.5 10 10 1 391.1 12.3 10 12 17 66.2 7.7 10 15 5 454.3 6.8 10 7 14 104.0 5.4 10 10 2 54.8 13.7 10 12 18 78.1 7.0 10 15 6 141.9 3.8 10 7 15 121.1 6.2 10 10 3 268.1 22.2 10 12 19 57.6 9.5 10 15 7 360.9 5.3 10 7 16 288.2 4.7 10 10 4 195.9 23.3 10 12 20 142.0 5.9 10 15 8 198.5 4.2 10 7 17 110.1 6.0 10 10 6 402.8 5.8 10 12 21 97.7 6.1 10 15 9 168.7 5.3 10 7 18 125.2 4.4 10 10 7 307.7 4.8 10 12 22 126.2 7.2 10 15 10 176.2 4.0 10 7 19 117.4 4.6 10 10 8 121.2 4.8 10 12 23 112.6 6.2 10 15 11 293.0 5.1 10 7 20 110.6 5.4 10 10 9 85.3 7.6 10 12 24 34.2 13.9 10 15 12 117.5 4.5 WO 99/10379 PCT/GB98/02542 -142 10 15 13 153.0 4.7 10 18 4 160.4 3.6 10 20 25 35.8 16.7 10 23 23 150.1 5.4 10 15 14 194.6 4.0 10 18 5 280.9 4.4 10 21 0 170.8 3.5 10 24 0 203.8 4.0 10 15 15 61.1 8.2 10 18 6 254.9 4.4 10 21 1 320.6 6.1 10 24 1 395.2 7.2 10 15 16 78.5 6.7 10 18 7 217.3 4.0 10 21 2 210.0 3.5 10 24 2 63.1 8.1 10 15 17 56.4 10.3 10 18 9 72.4 5.4 10 21 3 502.4 6.8 10 24 3 150.3 2.9 10 15 18 72.3 9.3 10 18 10 93.4 5.0 10 21 4 353.8 5.9 10 24 4 132.1 2.9 10 15 19 185.6 4.6 10 18 11 242.2 4.0 10 21 5 289.3 4.3 10 24 5 133.1 3.8 10 15 20 167.3 5.4 10 18 12 90.4 4.9 10 21 6 223.0 5.1 10 24 6 216.7 3.6 10 15 21 78.9 12.2 10 18 13 238.3 3.7 10 21 7 90.4 4.7 10 24 7 133.3 3.8 10 15 22 44.8 13.5 10 18 14 56.6 11.6 10 21 8 392.3 5.7 10 24 8 87.8 4.3 10 15 23 96.9 7.8 10 18 15 182.1 3.9 10 21 9 280.6 4.4 10 24 9 155.0 3.4 10 15 24 159.0 6.4 10 18 16 179.3 4.0 10 21 10 75.4 5.0 10 24 10 99.7 5.8 10 15 25 41.0 16.2 10 18 17 42.9 12.3 10 21 11 86.3 5.5 10 24 11 193.5 3.7 10 15 26 187.3 6.5 10 18 18 92.6 7.2 10 21 13 57.6 6.8 10 24 12 124.3 4.1 10 15 27 25.8 12.5 10 18 19 148.6 4.5 10 21 14 160.1 4.2 10 24 13 230.9 4.0 10 16 0 244.1 4.5 10 18 20 335.1 24.3 10 21 15 154.5 3.7 10 24 14 100.8 4.4 10 16 1 149.7 4.3 10 18 21 45.0 12.2 10 21 16 98.9 5.6 10 24 15 20.7 10.4 10 16 2 384.8 7.0 10 18 22 20.3 9.8 10 21 17 169.4 5.2 10 24 16 170.6 6.4 10 16 3 123.0 4.3 10 18 23 121.3 8.4 10 21 18 398.3 15.1 10 24 17 147.5 4.5 10 16 4 313.0 4.8 10 18 24 107.4 9.8 10 21 19 52.6 11.9 10 24 18 219.7 5.1 10 16 5 282.6 4.7 10 18 25 98.3 10.3 10 21 20 79.8 7.7 10 24 19 223.3 4.7 10 16 6 53.1 12.0 10 19 0 208.3 5.1 10 21 21 152.3 4.8 10 24 20 192.4 4.2 10 16 7 24.0 10.3 10 19 1 175.7 3.3 10 21 22 144.5 7.0 10 24 21 120.6 5.1 10 16 8 217.1 3.9 10 19 2 46.6 7.5 10 21 23 26.5 12.1 10 24 22 151.2 5.1 10 16 9 177.0 3.8 10 19 3 401.9 6.4 10 21 24 28.1 13.1 10 25 0 237.3 5.1 10 16 10 203.4 4.4 10 19 4 290.3 4.3 10 22 0 72.0 7.4 10 25 1 18.6 8.5 10 16 11 54.1 10.6 10 19 5 144.1 3.9 10 22 1 282.2 5.0 10 25 2 171.3 3.0 10 16 12 157.5 4.7 10 19 6 513.7 8.0 10 22 2 420.2 8.9 10 25 3 279.7 6.4 10 16 13 179.5 4.3 10 19 7 206.5 4.2 10 22 3 348.7 7.0 10 25 4 236.2 4.1 10 16 14 78.0 6.2 10 19 8 42.2 11.6 10 22 4 397.7 6.0 10 25 5 43.1 6.1 10 16 15 84.8 5.8 10 19 9 76.9 5.0 10 22 5 224.4 4.4 10 25 6 84.2 4.1 10 16 16 69.5 8.7 10 19 10 214.3 3.6 10 22 6 81.7 4.6 10 25 7 148.5 3.4 10 16 17 77.7 5.8 10 19 11 26.4 10.8 10 22 7 164.9 3.7 10 25 8 192.5 3.7 10 16 18 109.3 7.8 10 19 12 122.8 4.8 10 22 8 136.2 4.3 10 25 9 137.8 3.8 10 16 19 120.2 5.7 10 19 13 153.6 3.6 10 22 9 176.2 3.5 10 25 10 100.1 3.5 10 16 20 94.3 6.7 10 19 14 125.5 3.8 10 22 10 144.4 3.5 10 25 11 40.0 11.2 10 16 21 318.8 12.5 10 19 15 96.6 4.6 10 22 11 162.5 3.6 10 25 12 107.4 5.0 10 16 22 235.6 4.7 10 19 16 210.9 4.1 10 22 12 134.7 3.8 10 25 13 173.2 4.0 10 16 23 55.6 13.7 10 19 17 300.3 4.8 10 22 13 88.1 5.4 10 25 14 46.2 19.8 10 16 24 28.1 12.8 10 19 18 191.2 4.2 10 22 14 127.4 6.2 10 25 15 52.8 17.3 10 16 25 101.7 8.7 10 19 19 304.9 11.2 10 22 15 255.9 4.1 10 25 16 55.9 8.3 10 16 26 31.8 13.6 10 19 20 233.8 4.6 10 22 16 149.1 4.4 10 25 17 225.2 4.4 10 17 0 168.7 4.0 10 19 21 111.5 6.6 10 22 17 184.0 11.7 10 25 18 134.2 4.9 10 17 1 127.6 3.7 10 19 22 125.3 5.9 10 22 18 237.0 4.6 10 25 19 107.4 5.8 10 17 2 104.0 9.4 10 19 23 217.4 4.9 10 22 19 52.4 13.3 10 25 20 172.4 5.1 10 17 3 126.1 3.8 10 19 24 132.3 7.2 10 22 20 88.9 7.5 10 25 21 72.4 12.0 10 17 4 196.6 3.5 10 19 25 31.2 13.5 10 22 21 118.2 6.6 10 25 22 107.9 6.3 10 17 5 275.7 4.3 10 20 0 117.8 3.8 10 22 22 24.3 11.9 10 26 0 87.7 4.6 10 17 6 164.0 4.3 10 20 1 239.1 5.2 10 22 23 95.6 8.4 10 26 1 218.3 4.6 10 17 7 162.3 4.2 10 20 2 382.0 6.4 10 23 0 150.2 2.9 10 26 2 221.9 3.9 10 17 8 160.4 4.5 10 20 3 352.8 5.8 10 23 1 367.9 6.1 10 26 3 238.3 5.3 10 47 9 260.4 4.0 10 20 4 234.6 4.3 10 23 2 132.0 3.6 10 26 4 129.1 4.4 10 17 10 153.7 3.6 10 20 5 305.8 4.4 10 23 3 296.9 4.9 10 26 5 297.7 5.0 10 17 11 248.0 4.2 10 20 6 72.4 6.0 10 23 4 131.7 4.6 10 26 6 91.9 5.0 10 17 12 73.7 7.0 10 20 7 148.5 3.7 10 23 5 52.9 7.6 10 26 7 74.0 4.6 10 17 13 122.1 4.2 10 20 8 149.5 3.3 10 23 6 94.5 9.3 10 26 8 180.0 3.5 10 17 14 233.7 4.1 10 20 9 91.0 4.2 10 23 7 132.6 4.1 10 26 9 60.1 7.0 10 17 15 164.1 4.9 10 20 10 182.1 3.6 10 23 8 192.4 3.7 10 26 10 51.0 7.5 10 17 16 147.2 4.7 10 20 11 164.1 3.7 10 23 9 113.4 3.9 10 26 11 122.1 4.0 10 17 17 116.1 6.1 10 20 12 30.3 10.7 10 23 10 176.4 3.5 10 26 12 94.8 4.9 10 17 18 148.7 4.2 10 20 13 84.8 6.1 10 23 11 85.3 4.7 10 26 13 147.4 16.1 10 17 19 129.2 4.7 10 20 14 157.7 3.9 10 23 12 152.0 4.1 10 26 14 28.1 13.0 10 17 21 131.7 5.1 10 20 15 65.6 10.2 10 23 13 71.2 7.5 10 26 15 165.0 4.0 10 17 22 216.4 4.7 10 20 16 106.4 6.2 10 23 14 287.1 4.7 10 26 16 34.6 12.6 10 17 23 24.3 11.3 10 20 17 118.9 4.9 10 23 15 110.0 5.0 10 26 17 216.5 4.4 10 17 24 182.2 5.2 10 20 18 16.7 8.4 10 23 16 46.6 18.5 10 26 18 69.8 11.6 10 17 25 138.6 7.2 10 20 19 57.9 16.6 10 23 17 112.7 8.8 10 26 19 41.2 14.1 10 17 26 130.6 8.0 10 20 20 22.9 10.9 10 23 18 183.0 5.8 10 26 20 64.6 15.1 10 18 0 153.7 3.8 10 20 21 18.9 9.5 10 23 19 142.2 4.5 10 26 21 57.8 12.1 10 18 1 352.6 5.5 10 20 22 72.1 9.6 10 23 20 78.8 11.5 10 27 0 23.3 9.5 10 18 2 249.6 4.0 10 20 23 51.9 13.6 10 23 21 107.8 7.0 10 27 1 66.9 4.9 10 18 3 328.3 5.9 10 20 24 87.2 7.6 10 23 22 70.4 10.5 10 27 2 83.2 7.0 WO 99/10379 PCT/GB98/02542 -143 10 27 3 203.1 3.3 10 31 3 145.5 11.6 10 36 4 113.7 5.1 11 2 11 188.0 4.7 10 27 4 148.8 3.6 10 31 4 376.3 12.1 10 36 5 179.6 4.7 11 2 12 178.2 4.3 10 27 5 114.4 5.4 10 31 6 136.6 5.4 10 36 6 108.7 4.5 11 2 13 350.4 6.1 10 27 6 118.8 4.3 10 31 7 56.2 8.0 10 36 8 92.1 5.4 11 2 14 78.8 7.5 10 27 7 118.1 4.7 10 31 8 74.1 5.7 10 37 0 219.5 5.2 11 2 15 214.9 4.1 10 27 8 67.8 6.4 10 31 9 67.1 7.2 10 37 1 166.3 5.1 11 2 16 32.8 14.2 10 27 9 52.5 6.9 10 31 10 84.2 5.7 10 37 2 45.1 9.3 11 2 17 67.0 8.9 10 27 10 70.4 5.9 10 31 11 232.4 4.2 10 37 3 144.7 4.4 11 2 18 85.4 6.6 10 27 11 121.6 4.5 10 31 12 58.3 8.8 10 37 4 21.1 9.9 11 2 19 125.0 4.5 10 27 12 196.4 17.0 10 31 13 107.3 5.2 10 37 5 56.7 9.4 11 2 20 230.9 6.6 10 27 13 16.4 8.2 10 31 14 105.6 5.3 10 37 6 146.8 5.9 11 2 21 113.2 5.4 10 27 14 87.7 5.1 10 31 15 73.3 8.1 10 38 0 32.3 13.1 11 2 22 206.7 4.5 10 27 15 75.8 6.6 10 31 16 100.7 6.1 10 38 1 127.1 5.7 11 2 23 276.1 11.5 10 27 16 130.6 6.4 10 32 0 105.2 6.5 11 0 0 302.5 7.1 11 2 24 116.3 7.5 10 27 17 113.2 5.9 10 32 1 271.7 5.9 11 0 1 143.4 5.9 11 2 25 87.4 11.4 10 27 18 28.5 11.9 10 32 2 29.5 9.6 11 0 2 109.7 6.5 11 2 26 71.1 13.1 10 27 19 121.0 7.4 10 32 3 100.3 6.1 11 0 6 173.1 6.4 11 2 27 84.6 16.8 10 27 20 122.2 6.7 10 32 4 104.0 5.5 11 0 7 52.6 16.4 11 2 28 149.7 7.8 10 28 0 62.1 4.7 10 32 5 69.5 7.6 11 0 8 331.1 7.0 11 3 0 189.1 4.2 10 28 1 112.2 3.4 10 32 6 33.2 12.3 11 0 9 97.4 10.8 11 3 1 29.6 13.9 10 28 2 89.7 6.0 10 32 7 13.2 6.5 11 0 10 150.3 6.0 11 3 2 343.5 10.2 10 28 3 133.8 4.9 10 32 8 123.8 3.8 11 0 11 105.5 9.0 11 3 5 142.0 11.4 10 28 4 101.3 3.0 10 32 9 123.4 4.9 11 0 12 128.1 8.0 11 3 6 202.2 4.5 10 28 5 87.8 5.3 10 32 10 187.6 4.0 11 0 13 502.5 10.2 11 3 7 263.8 5.1 10 28 6 112.6 4.9 10 32 11 110.3 6.3 11 0 14 79.3 10.5 11 3 8 21.6 10.4 10 28 7 159.7 3.9 10 32 12 124.4 4.0 11 0 15 70.6 14.1 11 3 9 381.0 5.9 10 28 8 163.4 3.3 10 32 13 16.1 7.9 11 0 16 242.5 8.5 11 3 10 202.3 4.0 10 28 9 48.4 10.4 10 32 14 117.1 4.1 11 0 17 170.8 9.2 11 3 11 179.2 4.3 10 28 12 311.3 5.6 10 32 15 104.2 5.6 11 0 18 30.9 16.2 11 3 12 206.5 5.0 10 28 13 71.4 8.1 10 33 0 40.6 11.8 11 0 19 119.7 7.0 11 3 13 184.9 5.0 10 28 14 90.7 6.4 10 33 1 171.2 4.4 11 0 20 50.1 18.2 11 3 14 146.9 4.4 10 28 15 58.6 11.5 10 33 2 174.4 4.6 11 0 21 128.6 10.1 11 3 15 148.9 4.5 10 28 16 81.7 7.1 10 33 3 269.2 7.5 11 0 22 86.7 11.2 11 3 16 32.9 14.0 10 28 17 44.5 13.3 10 33 4 286.2 5.8 11 0 23 112.8 40.7 11 3 17 271.4 4.4 10 28 18 19.8 9.7 10 33 5 186.2 4.7 11 0 24 14.4 10.8 11 3 18 142.0 5.8 10 28 19 17.4 8.7 10 33 6 143.9 4.9 11 0 25 84.7 15.8 11 3 19 100.4 5.5 10 29 0 163.2 4.5 10 33 7 27.0 9.1 11 0 26 44.5 22.8 11 3 20 101.3 5.8 10 29 1 41.5 6.5 10 33 8 217.0 3.8 11 0 28 71.9 21.5 11 3 21 72.2 8.6 10 29 2 129.7 4.6 10 33 9 82.7 5.2 11 1 0 430.2 6.6 11 3 22 298.9 5.0 10 29 3 189.5 3.7 10 33 10 193.8 4.1 11 1 1 55.5 16.1 11 3 23 358.3 12.5 10 29 4 147.5 3.6 10 33 12 115.0 4.1 11 1 2 545.7 7.4 11 3 24 113.6 9.0 10 29 5 195.7 5.1 10 33 13 43.8 10.9 11 1 6 141.4 6.5 11 3 25 56.7 14.0 10 29 6 31.8 12.2 10 33 14 77.9 10.6 11 1 7 57.3 11.3 11 3 26 245.7 5.4 10 29 7 174.2 4.1 10 34 0 127.5 5.3 11 1 8 483.8 8.3 11 3 27 121.3 8.6 10 29 8 119.6 4.2 10 34 1 209.4 4.6 11 1 9 220.4 4.7 11 3 28 44.9 16.9 10 29 9 240.0 12.9 10 34 2 83.5 6.4 11 1 10 94.3 6.5 11 4 0 425.7 7.5 10 29 10 139.8 5.5 10 34 3 79.5 6.1 11 1 11 127.8 6.6 11 4 1 406.6 8.5 10 29 11 58.9 9.8 10 34 4 231.7 5.5 11 1 12 168.4 4.6 11 4 2 213.0 11.3 10 29 12 144.4 4.2 10 34 5 89.5 6.6 11 1 13 28.6 11.5 11 4 5 508.1 7.2 10 29 13 22.1 9.9 10 34 6 59.8 6.2 11 1 14 167.0 4.3 11 4 6 284.2 4.6 10 29 14 179.9 4.2 10 34 7 141.4 3.8 11 1 15 17.2 8.7 11 4 7 365.7 6.2 10 '29 15 196.5 4.2 10 34 8 99.1 5.5 11 1 16 27.0 12.2 11 4 8 63.3 12.4 10 29 16 114.6 5.5 10 34 9 95.7 6.3 11 1 17 218.2 4.3 11 4 9 25.5 11.7 10 29 17 141.8 5.0 10 34 10 61.3 7.0 11 1 18 110.5 4.7 11 4 10 92.6 6.0 10 29 18 131.3 5.6 10 34 11 99.3 5.6 11 1 19 18.7 9.1 11 4 12 32.2 12.3 10 30 0 109.0 3.7 10 34 12 135.9 4.1 11 1 20 31.2 12.5 11 4 13 178.3 4.2 10 30 1 77.4 6.1 10 35 0 143.4 5.1 11 1 21 66.0 9.3 11 4 14 20.1 9.9 10 30 2 62.0 8.5 10 35 1 73.1 7.3 11 1 22 173.9 4.8 11 4 15 71.4 10.3 10 30 3 132.6 3.5 10 35 2 96.6 5.9 11 1 23 211.8 15.6 11 4 16 247.0 5.2 10 30 4 251.9 5.3 10 35 3 54.3 9.8 11 1 24 51.5 16.6 11 4 17 79.1 7.0 10 30 5 110.9 5.7 10 35 4 132.3 3.5 11 1 25 177.2 9.0 11 4 18 110.1 5.6 10 30 8 154.1 4.0 10 35 5 80.8 6.4 11 1 26 54.9 15.4 11 4 19 149.9 4.4 10 30 9 72.2 6.8 10 35 6 27.4 10.2 11 1 27 92.7 13.6 11 4 20 107.4 6.4 10 30 10 58.5 6.7 10 35 7 198.1 5.0 11 1 28 162.9 7.2 11 4 21 165.4 5.3 10 30 11 188.6 4.0 10 35 8 42.2 13.0 11 2 0 387.8 6.0 11 4 22 66.9 10.7 10 30 12 298.4 4.6 10 35 9 40.2 10.9 11 2 2 119.8 10.7 11 4 23 468.1 12.6 10 30 13 75.7 10.0 10 35 10 67.9 5.8 11 2 4 525.0 22.2 11 4 24 118.6 11.7 10 30 14 136.4 5.5 10 35 11 22.2 11.1 11 2 6 234.1 4.4 11 4 25 28.0 12.9 10 30 15 31.8 12.4 10 36 0 56.6 8.3 11 2 7 385.3 5.7 11 4 26 101.9 10.1 10 30 16 90.9 7.2 10 36 1 68.4 7.3 11 2 8 85.0 7.2 11 4 27 110.2 9.6 10 30 17 136.0 5.7 10 36 2 67.6 6.0 11 2 9 102.8 6.5 11 4 28 125.1 8.7 10 31 1 70.9 9.6 10 36 3 94.5 5.4 11 2 10 160.9 4.2 11 5 1 107.8 27.4 WO 99/10379 PCT/GB98/02542 -144 11 5 2 410.8 21.0 11 7 21 94.0 6.7 11 10 10 251.0 4.3 11 13 0 363.7 6.4 11 5 5 211.5 5.0 11 7 22 23.5 11.4 11 10 11 215.4 4.1 11 13 1 107.1 7.1 11 5 6 104.3 5.7 11 7 24 240.7 5.8 11 10 12 339.3 5.7 11 13 2 163.5 5.5 11 5 7 273.8 5.8 11 7 25 130.9 10.5 11 10 13 111.3 4.8 11 13 3 298.7 5.1 11 5 8 685.6 9.6 11 7 26 137.3 8.0 11 10 14 208.3 3.9 11 13 4 80.5 6.3 11 5 9 364.5 6.3 11 7 27 85.3 13.3 11 10 15 153.2 3.9 11 13 5 389.7 6.1 11 5 10 213.3 4.4 11 7 28 68.6 15.9 11 10 16 106.7 5.0 11 13 6 146.2 3.8 11 5 11 141.6 4.5 11 8 0 333.1 5.7 11 10 17 199.2 4.0 11 13 7 192.3 4.4 11 5 12 51.4 13.9 11 8 1 276.8 5.0 11 10 18 115.4 12.4 11 13 8 249.3 5.2 11 5 13 232.4 4.8 11 8 2 658.2 11.1 11 10 19 164.4 4.7 11 13 9 305.1 4.6 11 5 14 277.5 4.6 11 8 3 132.7 4.3 11 10 20 213.2 4.3 11 13 10 126.2 4.7 11 5 15 203.8 4.3 11 8 4 96.7 5.0 11 10 21 24.5 11.7 11 13 11 134.9 4.2 11 5 16 159.7 4.2 11 8 5 334.2 6.1 11 10 22 272.3 11.2 11 13 12 69.1 6.9 11 5 17 58.4 9.2 11 8 6 206.0 5.5 11 10 23 130.8 7.6 11 13 13 299.6 5.0 11 5 18 26.6 11.5 11 8 7 128.9 5.3 11 10 24 29.0 13.4 11 13 14 180.7 3.9 11 5 19 133.3 5.4 11 8 8 232.5 4.3 11 10 25 106.1 7.7 11 13 15 18.0 8.7 11 5 20 70.7 8.6 11 8 9 353.2 5.9 11 10 26 37.8 16.8 11 13 16 61.5 8.1 11 5 21 86.1 7.5 11 8 10 262.6 5.3 11 10 27 27.2 12.9 11 13 17 148.7 4.0 11 5 22 142.5 5.5 11 8 11 193.9 6.8 11 11 0 284.1 5.3 11 13 18 170.9 5.0 11 5 23 315.2 12.6 11 8 12 201.4 4.8 11 11 1 158.3 3.5 11 13 19 118.8 6.0 11 5 24 36.3 14.5 11 8 13 226.7 4.5 11 11 2 496.5 10.7 11 13 20 36.9 12.9 11 5 25 210.4 5.3 11 8 14 36.0 13.0 11 11 3 90.3 6.7 11 13 21 315.2 15.2 11 5 26 162.5 5.7 11 8 15 232.7 4.7 11 11 4 601.7 9.6 11 13 22 173.3 4.8 11 5 27 93.3 9.4 11 8 16 93.8 6.5 11 11 5 192.4 4.0 11 13 23 31.5 13.1 11 5 28 74.9 15.8 11 8 17 53.0 14.7 11 11 6 292.0 5.1 11 13 24 85.6 11.2 11 6 0 835.4 28.0 11 8 18 61.9 9.5 11 11 7 297.7 5.6 11 13 25 23.9 11.7 11 6 1 289.7 18.4 11 8 19 38.1 12.3 11 11 8 346.3 5.4 11 13 26 19.4 9.7 11 6 4 312.3 4.8 11 8 20 91.5 10.1 11 11 9 151.3 6.2 11 14 0 530.8 8.0 11 6 5 134.8 4.5 11 8 21 96.6 5.7 11 11 10 276.3 4.7 11 14 1 350.7 6.1 11 6 6 735.7 11.1 11 8 22 36.5 17.0 11 11 11 131.1 4.3 11 14 2 244.7 4.2 11 6 7 81.0 11.4 11 8 24 121.2 9.9 11 11 12 209.6 4.4 11 14 3 146.1 6.2 11 6 8 481.8 6.6 11 8 25 112.7 7.6 11 11 13 148.2 4.6 11 14 4 227.0 3.8 11 6 9 120.3 6.1 11 8 26 41.6 15.0 11 11 14 157.4 5.1 11 14 5 261.1 4.0 11 6 10 219.2 4.3 11 8 27 19.1 9.7 11 11 15 196.1 4.5 11 14 6 233.2 4.4 11 6 11 108.0 5.8 11 9 0 59.3 14.5 11 11 16 121.7 5.2 11 14 7 52.9 11.2 11 6 12 39.3 12.1 11 9 1 433.7 6.4 11 11 17 170.3 3.7 11 14 8 230.4 3.9 11 6 13 183.3 4.0 11 9 2 175.7 3.4 11 11 18 20.7 10.2 11 14 9 245.8 4.9 11 6 14 49.9 9.9 11 9 3 225.0 5.2 11 11 19 136.9 5.6 11 14 10 76.6 7.6 11 6 15 104.1 5.2 11 9 4 139.5 4.7 11 11 20 82.1 8.3 11 14 11 156.3 5.0 11 6 16 136.4 6.7 11 9 5 145.0 5.1 11 11 21 30.8 13.6 11 14 12 165.9 4.9 11 6 17 203.9 4.1 11 9 6 594.3 8.1 11 11 23 101.0 8.1 11 14 13 166.5 4.1 11 6 18 189.1 3.9 11 9 7 164.0 4.5 11 11 24 174.3 4.6 11 14 14 221.6 3.9 11 6 19 200.7 4.5 11 9 8 340.3 5.4 11 11 25 106.3 9.1 11 14 15 141.9 5.2 11 6 20 153.0 4.9 11 9 9 225.0 4.3 11 11 26 141.5 8.0 11 14 16 59.2 9.7 11 6 21 183.3 4.9 11 9 10 287.3 5.2 11 11 27 86.4 9.9 11 14 17 151.9 4.3 11 6 22 89.1 9.3 11 9 11 92.9 7.1 11 12 0 176.1 4.1 11 14 18 60.4 9.7 11 6 24 92.3 8.7 11 9 12 98.8 6.1 11 12 1 236.3 4.1 11 14 19 181.0 4.5 11 6 25 40.4 15.2 11 9 13 16.0 8.1 11 12 2 83.9 4.2 11 14 20 130.3 11.3 11 6 26 207.9 6.7 11 9 14 63.8 7.8 11 12 3 29.9 12.0 11 14 21 135.8 7.7 11 6 27 54.3 15.5 11 9 15 238.6 4.4 11 12 4 173.5 3.6 11 14 22 116.6 6.2 11 6 28 26.3 12.9 11 9 16 41.2 13.1 11 12 5 111.5 4.6 11 14 23 116.9 6.9 11 -7 0 410.0 14.2 11 9 17 216.1 4.2 11 12 6 173.2 3.7 11 14 24 152.6 6.4 11 7 1 156.9 23.7 11 9 18 51.4 14.7 11 12 7 84.7 7.5 11 14 25 87.8 10.3 11 7 2 209.9 7.2 11 9 19 117.1 5.1 11 12 8 202.7 4.7 11 14 26 110.1 7.9 11 7 3 244.4 4.3 11 9 20 138.4 4.5 11 12 9 349.1 5.4 11 15 0 174.9 3.7 11 7 4 578.8 8.6 11 9 21 111.0 6.3 11 12 10 245.6 4.3 11 15 1 139.6 5.7 11 7 5 182.5 4.6 11 9 22 329.1 13.4 11 12 11 280.8 4.7 11 15 2 244.1 4.5 11 7 6 94.8 5.7 11 9 23 121.7 9.4 11 12 12 168.5 5.8 11 15 3 149.7 4.2 11 7 7 213.2 5.4 11 9 24 60.7 14.5 11 12 13 223.9 4.1 11 15 4 452.8 8.9 11 7 8 308.8 6.4 11 9 25 91.6 10.7 11 12 14 197.4 4.0 11 15 5 217.1 4.1 11 7 9 110.0 6.0 11 9 26 137.8 8.3 11 12 15 266.1 4.9 11 15 6 326.6 5.1 11 7 10 114.4 5.4 11 9 27 101.0 10.3 11 12 16 48.1 11.0 11 15 7 108.5 4.7 11 7 11 297.1 4.7 11 10 0 353.7 6.3 11 12 17 90.5 6.0 11 15 8 183.2 4.1 11 7 12 121.0 4.8 11 10 1 510.8 7.4 11 12 18 77.9 7.1 11 15 9 86.0 5.9 11 7 13 179.5 4.7 11 10 2 170.0 4.0 11 12 19 34.2 13.3 11 15 10 153.9 4.2 11 7 14 206.2 3.9 11 10 3 155.1 5.8 11 12 20 154.8 5.3 11 15 11 162.8 3.6 11 7 15 46.6 15.1 11 10 4 312.6 5.5 11 12 21 248.0 13.0 11 15 12 126.7 4.5 11 7 16 173.3 4.7 11 10 5 47.0 14.4 11 12 22 151.9 5.6 11 15 13 164.9 3.9 11 7 17 183.9 4.9 11 10 6 544.0 8.1 11 12 23 158.8 4.8 11 15 14 133.8 4.4 11 7 18 130.0 4.3 11 10 7 401.5 6.2 11 12 24 167.7 5.0 11 15 15 32.7 12.1 11 7 19 114.9 6.0 11 10 8 26.8 12.3 11 12 25 119.5 9.4 11 15 16 109.1 5.2 11 7 20 46.6 12.7 11 10 9 326.8 5.2 11 12 26 108.0 9.1 11 15 17 65.1 9.0 WO 99/10379 PCT/GB98/02542 -145 11 15 18 94.4 8.2 11 18 12 154.9 4.2 11 21 11 194.9 4.4 11 24 14 119.2 22.5 11 15 19 145.6 4.7 11 18 13 77.8 6.5 11 21 12 233.1 4.0 11 24 15 24.2 11.2 11 15 20 357.9 12.3 11 18 14 95.8 5.9 11 21 13 138.6 4.7 11 24 16 19.7 9.5 11 15 21 85.8 8.6 11 18 15 124.8 5.4 11 21 14 72.7 7.0 11 24 17 81.3 10.1 11 15 22 65.2 10.5 11 18 16 156.1 3.8 11 21 15 213.8 4.1 11 24 18 140.8 5.3 11 15 23 91.5 8.0 11 18 17 23.7 11.4 11 21 16 50.8 19.7 11 24 19 167.8 5.2 11 15 24 21.9 10.8 11 18 18 95.9 10.9 11 21 17 102.4 8.8 11 24 20 81.7 9.7 11 15 25 35.4 15.0 11 18 19 113.0 5.5 11 21 18 189.0 4.7 11 24 21 121.2 6.0 11 15 26 74.6 18.6 11 18 20 40.4 13.9 11 21 19 78.5 10.1 11 25 0 158.6 4.8 11 16 0 250.2 4.0 11 18 21 197.3 5.0 11 21 20 24.8 11.3 11 25 1 219.6 4.3 11 16 1 418.5 6.7 11 18 22 138.6 7.9 11 21 21 110.4 9.8 11 25 2 135.6 5.0 11 16 2 238.5 3.8 11 18 23 164.5 5.4 11 21 22 141.0 5.2 11 25 3 309.6 6.1 11 16 3 173.8 3.7 11 18 24 64.6 16.6 11 21 23 34.1 13.2 11 25 4 113.0 3.7 11 16 4 339.4 4.9 11 19 0 112.5 5.2 11 22 0 240.0 5.0 11 25 5 140.8 3.0 11 16 5 298.0 5.1 11 19 1 76.0 4.2 1122 1 171.5 4.7 11 25 6 79.2 6.4 1116 6 227.9 3.8 11 19 2 259.7 4.8 1122 2 62.0 6.1 1125 7 135.2 3.3 11 16 7 106.3 5.6 11 19 3 284.3 5.0 11 22 3 281.4 4.5 11 25 8 73.7 7.0 11 16 8 226.3 4.1 11 19 4 206.7 4.0 11 22 4 232.8 3.8 11 25 9 160.0 4.1 11 16 9 127.4 4.6 11 19 5 239.1 3.8 11 22 5 99.8 4.1 11 25 10 137.7 4.6 11 16 10 317.1 4.9 11 19 6 130.6 3.7 11 22 6 113.0 4.0 11 25 11 103.9 4.6 11 16 11 237.2 4.0 11 19 7 124.5 3.7 11 22 7 166.5 3.7 11 25 12 154.9 11.8 11 16 12 251.6 4.2 11 19 8 60.2 10.0 11 22 8 170.8 3.4 11 25 13 246.5 13.8 11 16 13 102.2 6.5 11 19 9 190.5 3.6 11 22 9 41.5 12.3 11 25 14 181.8 4.7 11 16 14 125.7 4.4 11 19 10 30.6 12.1 11 22 10 27.2 10.5 11 25 15 43.5 14.0 11 16 15 61.0 7.1 11 19 11 113.9 4.9 11 22 11 106.3 5.6 11 25 16 171.8 5.3 11 16 16 139.1 4.8 11 19 12 17.2 8.5 11 22 12 92.8 6.0 11 25 17 123.4 6.6 11 16 17 247.3 4.7 11 19 13 38.5 11.8 11 22 13 24.7 10.7 11 25 18 152.1 5.9 11 16 18 127.5 7.1 11 19 14 107.8 5.2 11 22 14 65.5 7.0 11 25 19 93.7 10.3 11 16 19 189.1 6.9 11 19 15 81.4 6.0 11 22 15 82.6 7.5 11 25 20 124.7 6.5 11 16 21 152.1 6.9 11 19 16 162.4 4.6 11 22 16 20.1 9.8 11 26 0 138.9 4.9 11 16 22 123.7 7.2 11 19 17 17.7 8.7 11 22 17 74.4 8.6 11 26 1 135.8 2.9 11 16 23 186.1 6.4 11 19 18 275.2 12.3 11 22 18 152.9 4.9 11 26 2 84.0 3.6 11 16 24 149.7 6.4 11 19 19 20.3 10.2 11 22 19 148.7 5.4 11 26 3 172.8 3.5 11 16 25 211.7 6.2 11 19 20 210.4 5.6 11 22 20 128.4 8.1 11 26 4 189.7 4.9 11 17 0 531.0 7.2 11 19 21 122.1 6.1 11 22 21 20.1 9.9 11 26 5 96.9 4.2 11 17 1 27.7 11.1 11 19 22 43.7 13.9 11 22 22 88.2 8.5 11 26 6 20.4 9.7 11 17 2 385.3 6.7 11 19 23 122.1 6.4 11 23 0 176.5 3.1 11 26 7 135.7 3.5 11 17 3 209.1 3.7 11 19 24 44.0 17.1 11 23 1 101.0 4.0 11 26 8 106.2 4.9 11 17 4 127.8 4.2 11 20 0 364.1 5.6 11 23 2 72.4 4.9 11 26 9 32.8 10.9 11 17 5 131.7 4.5 11 20 1 139.7 3.8 11 23 3 273.9 5.0 11 26 10 127.6 4.6 11 17 6 76.8 5.8 11 20 2 174.0 3.8 11 23 4 127.7 4.6 11 26 12 203.4 6.9 11 17 7 143.1 4.1 11 20 3 92.2 3.2 11 23 5 208.4 4.0 11 26 13 57.9 9.5 11 17 8 212.1 3.7 11 20 4 116.7 3.9 11 23 6 94.0 4.7 11 26 14 212.4 4.4 11 17 9 196.5 3.7 11 20 5 59.8 5.1 11 23 7 64.4 7.1 11 26 15 98.5 5.5 11 17 10 68.0 6.7 11 20 6 67.1 6.2 11 23 8 252.0 4.1 11 26 16 129.1 5.6 11 17 11 187.2 3.7 11 20 7 133.5 5.0 11 23 9 107.4 4.2 11 26 17 259.2 5.7 11 17 12 113.7 4.7 11 20 8 154.8 3.6 11 23 10 45.8 9.4 11 26 18 144.2 6.1 11 17 13 18.0 8.9 11 20 9 215.2 3.6 11 23 11 120.1 4.0 11 26 19 72.1 9.0 11 17 14 84.8 6.5 11 20 10 246.4 4.2 11 23 12 80.7 6.6 11 26 20 29.3 14.7 11 17 15 153.3 5.3 11 20 11 114.7 4.4 11 23 13 135.6 4.1 11 27 0 349.2 5.7 11 17 16 94.0 5.9 11 20 12 108.2 4.9 11 23 14 148.3 4.9 11 27 1 163.3 4.2 11 47 17 21.1 10.1 11 20 13 96.5 4.4 11 23 15 112.6 26.6 11 27 2 112.3 3.2 11 17 18 108.0 4.9 11 20 14 105.6 4.8 11 23 16 144.3 4.8 11 27 3 245.6 4.6 11 17 19 398.5 11.4 11 20 15 73.1 7.4 11 23 17 69.6 8.1 11 27 4 185.1 3.9 11 17 20 21.1 10.7 11 20 16 31.6 11.5 11 23 18 133.9 5.8 11 27 5 74.3 4.5 11 17 21 122.0 6.8 11 20 17 290.5 22.6 11 23 19 145.6 6.8 11 27 6 135.1 5.1 11 17 22 128.7 6.6 11 20 18 90.0 8.3 11 23 20 19.6 9.7 11 27 7 106.4 4.5 11 17 23 158.3 6.3 11 20 19 171.3 4.7 11 23 21 55.5 14.4 11 27 8 176.3 4.2 11 17 24 123.2 6.6 11 20 20 168.1 5.0 11 23 22 88.6 9.5 11 27 9 130.2 6.6 11 17 25 123.7 8.1 11 20 21 201.2 6.1 11 24 0 214.5 3.6 11 27 12 22.0 10.4 11 18 0 132.8 3.8 11 20 23 60.2 15.8 11 24 1 100.8 3.8 11 27 13 23.7 11.0 11 18 1 310.8 4.8 11 21 0 220.4 4.2 11 24 2 101.5 4.1 11 27 14 90.3 7.4 11 18 2 73.7 5.7 11 21 1 200.0 3.9 11 24 3 223.1 3.9 11 27 15 42.7 13.0 11 18 3 185.1 3.9 11 21 2 183.7 3.8 11 24 4 17.0 7.7 11 27 16 44.4 11.7 11 18 4 483.3 8.1 11 21 3 137.6 5.0 11 24 5 225.4 3.6 11 27 17 21.3 10.2 11 18 5 223.4 4.4 11 21 4 165.5 6.4 11 24 6 115.3 4.9 11 27 18 96.4 7.1 11 18 6 94.8 4.6 11 21 5 121.1 4.1 11 24 7 216.4 3.6 11 27 19 27.6 12.9 11 18 7 179.3 3.6 11 21 6 82.4 5.1 11 24 8 108.7 6.0 11 28 0 286.0 5.9 11 18 8 67.3 5.7 11 21 7 264.8 4.3 11 24 9 25.1 10.6 11 28 1 108.4 6.1 11 18 9 170.3 4.3 11 21 8 314.6 4.6 11 24 10 99.4 4.2 11 28 2 79.1 5.0 11 18 10 36.8 14.4 11 21 9 136.6 4.6 11 24 11 96.8 6.7 11 28 3 171.6 3.6 11 18 11 51.5 7.8 11 21 10 141.7 4.5 11 24 12 29.6 12.1 11 28 4 185.5 4.3 WO 99/10379 PCT/GB98/02542 -146 11 28 5 77.5 4.7 11 32 12 127.7 5.3 12 1 3 246.9 4.3 12 3 19 191.6 4.5 11 28 6 278.6 6.4 11 32 13 46.7 11.7 12 1 4 74.5 8.8 12 3 20 86.1 7.8 11 28 7 19.2 8.9 11 33 0 46.4 13.2 12 1 5 173.9 5.3 12 3 21 88.3 8.5 11 28 9 56.5 12.5 11 33 1 90.0 10.0 12 1 6 304.0 5.2 12 3 22 261.3 15.8 11 28 10 25.3 10.9 11 33 2 152.7 5.1 12 1 7 94.6 8.1 12 3 23 100.0 7.2 11 28 11 90.5 5.1 11 33 3 260.7 4.5 12 1 8 78.2 7.3 12 3 24 45.6 15.5 11 28 12 215.9 4.1 11 33 4 128.5 4.4 12 1 9 135.6 5.5 12 3 25 168.5 8.5 11 28 13 59.5 12.1 11 33 5 118.4 3.5 12 1 10 79.6 8.3 12 3 26 76.7 15.7 11 28 14 156.1 4.2 11 33 6 47.3 10.2 12 1 11 163.0 4.2 12 3 27 24.7 12.3 11 28 15 40.0 12.2 11 33 7 227.7 5.9 12 1 12 213.6 4.2 12 4 0 514.5 7.0 11 28 16 123.1 5.9 11 33 8 56.5 10.7 12 1 13 100.3 7.7 12 4 1 368.4 5.6 11 28 17 34.7 13.1 11 33 9 199.6 4.1 12 1 14 89.0 8.1 12 4 2 121.8 5.1 11 28 18 49.0 15.8 11 33 10 72.2 7.4 12 1 15 231.2 4.4 12 4 3 247.9 5.2 11 29 0 29.5 12.3 11 33 11 101.2 4.6 12 1 16 102.3 7.3 12 4 4 181.2 4.7 11 29 1 60.2 6.9 11 33 12 67.0 8.5 12 1 17 63.4 13.0 12 4 5 59.0 10.6 11 29 2 73.9 11.0 11 34 0 176.9 5.2 12 1 18 193.7 5.0 12 4 6 201.4 4.6 11 29 3 17.0 8.1 11 34 1 120.1 5.5 12 1 19 66.4 10.0 12 4 7 101.5 5.6 11 29 4 250.7 4.8 11 34 2 137.2 6.2 12 1 20 188.3 5.7 12 4 8 174.5 4.3 11 29 5 150.2 13.0 11 34 3 69.4 5.5 12 1 21 200.7 6.7 12 4 10 23.0 10.5 11 29 7 21.2 10.2 11 34 4 137.4 4.1 12 1 22 274.9 15.8 12 4 11 48.6 11.5 11 29 8 79.8 7.3 11 34 5 103.3 4.2 12 1 23 46.7 14.3 12 4 12 45.6 13.2 11 29 9 170.5 3.9 11 34 6 25.5 10.0 12 1 24 94.2 9.1 12 4 13 36.1 13.9 11 29 10 117.4 4.1 11 34 7 78.5 8.0 12 1 25 111.4 9.7 12 4 14 155.4 4.2 11 29 11 113.5 4.5 11 34 8 65.1 7.9 12 1 26 140.0 10.4 12 4 15 96.9 7.5 11 29 12 161.6 4.0 11 34 9 25.2 11.6 12 1 27 105.2 9.6 12 4 16 201.5 4.1 11 29 13 116.7 6.2 11 34 10 21.4 10.2 12 2 0 200.6 6.5 12 4 17 151.3 5.4 11 29 14 156.3 4.9 11 35 0 113.6 5.9 12 2 1 699.3 13.2 12 4 18 104.6 5.4 11 29 15 94.0 7.2 11 35 1 111.0 5.3 12 2 2 162.6 10.0 12 4 19 118.1 6.3 11 29 16 88.9 6.7 11 35 2 84.8 6.4 12 2 3 658.2 9.5 12 4 20 117.0 6.0 11 29 17 123.7 6.1 11 35 3 114.4 5.4 12 2 4 138.3 5.4 12 4 21 214.6 5.0 11 30 1 262.2 8.4 11 35 4 17.9 8.8 12 2 5 232.3 4.3 12 4 22 38.5 18.1 11 30 4 12.3 6.2 11 35 5 74.1 5.4 12 2 6 451.5 7.3 12 4 23 78.9 9.2 11 30 5 145.0 3.7 11 35 6 68.1 4.7 12 2 7 117.2 5.7 12 4 24 43.2 15.8 11 30 6 84.2 7.6 11 35 7 66.6 9.5 12 2 8 346.6 5.4 12 4 25 130.4 7.4 11 30 7 180.7 4.2 11 35 8 83.9 11.6 12 2 9 47.1 11.4 12 4 26 117.7 13.5 11 30 8 14.4 7.1 11 36 0 189.9 4.9 12 2 10 188.4 4.6 12 4 27 90.9 10.5 11 30 9 52.8 10.6 11 36 1 190.2 4.6 12 2 11 282.9 5.0 12 5 0 146.3 4.2 11 30 10 100.9 5.7 11 36 2 154.3 5.0 12 2 12 275.4 4.9 12 5 1 204.4 4.6 11 30 11 54.5 10.9 11 36 3 55.1 10.4 12 2 13 123.9 6.5 12 5 2 201.8 5.1 11 30 12 253.5 4.5 11 36 4 84.7 6.6 12 2 14 114.1 5.5 12 5 3 234.6 5.2 11 30 13 96.4 7.6 11 36 5 107.3 4.8 12 2 15 106.3 6.8 12 5 4 196.9 4.3 11 30 14 54.7 9.8 12 0 0 86.6 23.5 12 2 16 27.0 11.9 12 5 5 198.4 4.4 11 30 15 24.6 12.0 12 0 1 202.8 9.4 12 2 17 130.6 8.7 12 5 6 250.9 4.7 11 30 16 69.2 8.7 12 0 2 254.2 10.0 12 2 18 108.3 5.5 12 5 7 230.4 4.2 11 31 0 31.1 12.6 12 0 3 466.1 9.2 12 2 19 68.2 9.1 12 5 8 271.3 4.6 11 31 1 84.0 4.9 12 0 4 212.2 6.9 12 2 20 26.0 12.0 12 5 9 160.0 4.8 11 31 2 41.8 10.3 12 0 5 13.9 10.3 12 2 21 120.6 6.4 12 5 10 251.1 4.3 11 31 3 151.7 3.4 12 0 6 211.5 5.8 12 2 22 305.5 17.1 12 5 11 105.3 6.3 11 31 4 79.7 5.4 12 0 7 68.2 16.4 12 2 23 118.3 6.1 12 5 12 154.2 4.3 11 31 5 57.1 7.2 12 0 8 77.7 10.5 12 2 24 53.1 14.6 12 5 13 335.4 5.7 11 31 6 145.1 5.1 12 0 9 76.0 11.1 12 2 25 128.0 8.0 12 5 14 163.8 4.5 11 31 7 96.1 4.7 12 0 10 531.4 10.1 12 2 26 71.5 14.8 12 5 15 389.9 5.5 11 31 8 60.9 9.4 12 0 11 83.5 10.9 12 2 27 25.3 12.3 12 5 16 32.2 12.7 11 31 9 63.7 8.3 12 0 12 147.8 6.6 12 3 0 468.2 12.8 12 5 17 194.3 5.5 11 31 10 205.2 3.9 12 0 13 23.2 15.7 12 3 1 220.5 5.5 12 5 18 46.5 12.1 11 31 11 154.2 4.4 12 0 14 83.9 11.9 12 3 2 280.5 6.8 12 5 19 95.0 6.6 11 31 12 167.4 4.1 12 0 15 154.2 6.3 12 3 3 407.3 6.8 12 5 20 76.2 9.1 11 31 13 184.1 4.8 12 0 16 93.4 12.3 12 3 4 265.2 5.4 12 5 21 167.7 6.9 11 31 14 126.6 4.8 12 0 17 81.9 10.5 12 3 5 188.6 4.8 12 5 22 24.6 12.1 11 31 15 55.6 12.5 12 0 18 147.0 6.0 12 3 6 368.3 6.2 12 5 23 26.1 12.2 11 32 0 103.0 5.9 12 0 19 81.9 16.3 12 3 7 404.7 5.9 12 5 24 64.6 14.8 11 32 1 221.1 5.9 12 0 20 22.0 15.4 12 3 8 94.4 6.7 12 5 25 109.4 8.0 11 32 2 109.1 3.5 12 0 21 27.1 17.8 12 3 9 90.6 5.9 12 5 26 110.5 9.4 11 32 3 109.8 3.5 12 0 22 247.8 14.3 12 3 10 20.4 9.8 12 6 0 307.5 5.0 11 32 4 74.8 5.0 12 0 23 43.4 19.4 12 3 11 155.9 4.8 12 6 1 363.9 5.7 11 32 5 50.1 7.2 12 0 24 76.3 19.0 12 3 12 92.8 5.7 12 6 2 130.5 4.9 11 32 6 95.3 4.3 12 0 25 167.8 8.9 12 3 13 55.5 14.6 12 6 3 533.3 10.2 11 32 7 63.3 8.0 12 0 26 36.5 23.0 12 3 14 171.7 5.1 12 6 4 412.4 6.8 11 32 8 102.6 5.3 12 0 27 163.3 10.6 12 3 15 79.7 7.8 12 6 5 208.1 4.1 11 32 9 94.2 5.8 12 1 0 71.9 17.1 12 3 16 112.0 6.6 12 6 6 73.0 6.7 11 32 10 133.4 6.9 12 1 1 124.9 9.5 12 3 17 29.8 12.7 12 6 7 108.8 5.2 11 32 11 87.7 6.4 12 1 2 266.2 4.9 12 3 18 144.8 4.9 12 6 8 117.7 7.6 WO 99/10379 PCT/GB98/02542 -147 12 6 9 181.3 4.0 12 8 26 171.7 8.5 12 11 18 38.6 13.7 12 14 12 111.6 7.6 12 6 10 353.2 5.2 12 9 0 368.8 6.4 12 11 19 71.9 17.9 12 14 13 110.3 6.0 12 6 11 152.8 4.8 12 9 1 373.4 6.1 12 11 20 328.5 9.2 12 14 14 258.7 4.2 12 6 12 152.8 4.2 12 9 2 413.2 6.8 12 11 21 191.4 7.4 12 14 15 98.7 8.0 12 6 13 82.2 6.2 12 9 3 218.0 4.6 12 11 22 84.0 9.5 12 14 16 48.4 13.1 12 6 14 114.0 6.0 12 9 4 220.4 4.5 12 11 23 144.5 7.9 12 14 17 184.5 5.0 12 6 15 97.6 7.3 12 9 5 268.3 4.7 12 11 24 19.0 9.7 12 14 18 40.2 12.8 12 6 16 206.2 5.1 12 9 6 157.9 4.6 12 11 25 43.0 17.8 12 14 19 385.4 12.6 12 6 17 35.9 13.6 12 9 7 584.8 8.5 12 11 26 55.9 16.0 12 14 20 259.6 5.5 12 6 18 111.1 7.0 12 9 8 55.9 8.9 12 12 0 93.5 4.9 12 14 21 157.4 5.6 12 6 19 154.4 5.3 12 9 9 129.5 6.1 12 12 1 182.0 3.6 12 14 22 75.1 10.5 12 6 20 100.0 13.1 12 9 10 131.8 4.2 12 12 2 229.7 3.9 12 14 23 22.2 11.0 12 6 21 92.9 23.8 12 9 11 165.1 4.7 12 12 3 312.8 4.8 12 14 24 52.4 15.3 12 6 22 28.2 12.9 12 9 12 109.4 6.1 12 12 4 362.9 5.3 12 14 25 23.8 11.5 12 6 23 100.5 7.1 12 9 13 104.2 6.2 12 12 5 134.5 4.1 12 15 0 145.0 6.4 12 6 24 165.1 6.3 12 9 14 21.5 9.7 12 12 6 296.7 4.7 12 15 1 334.3 5.2 12 6 25 41.9 16.5 12 9 15 187.8 4.3 12 12 7 161.5 4.4 12 15 2 171.1 6.2 12 6 26 49.8 19.0 12 9 16 15.1 7.6 12 12 8 270.2 4.8 12 15 3 283.5 6.0 12 6 27 118.9 14.3 12 9 17 125.0 6.0 12 12 9 115.9 4.3 12 15 4 273.3 6.4 12 7 0 330.9 5.0 12 9 18 56.2 11.5 12 12 10 199.2 4.0 12 15 5 233.2 4.1 12 7 1 264.8 4.3 12 9 19 31.6 12.8 12 12 11 37.4 12.1 12 15 6 113.3 4.3 12 7 2 172.6 5.2 12 9 20 134.0 5.6 12 12 12 164.7 4.6 12 15 7 68.7 7.8 12 7 3 237.1 4.9 12 9 21 121.1 15.6 12 12 13 119.7 4.9 12 15 8 65.2 6.0 12 7 4 338.3 6.5 12 9 22 83.9 8.0 12 12 14 229.3 4.0 12 15 9 210.2 4.3 12 7 5 128.0 5.3 12 9 23 102.1 10.7 12 12 15 28.3 11.7 12 15 10 91.4 4.9 12 7 6 232.9 4.3 12 9 24 178.4 5.9 12 12 16 157.1 5.3 12 15 11 112.3 5.4 12 7 7 177.8 5.2 12 9 25 78.5 13.0 12 12 17 153.3 5.4 12 15 12 190.1 5.0 12 7 8 114.1 5.3 12 9 26 160.4 8.1 12 12 18 48.9 13.0 12 15 13 60.4 9.0 12 7 9 62.0 9.0 12 10 0 581.2 10.1 12 12 19 166.5 4.8 12 15 14 65.8 7.8 12 7 10 146.1 5.5 12 10 1 266.2 5.5 12 12 20 226.1 17.9 12 15 15 215.0 4.4 12 7 11 66.8 7.9 12 10 2 78.1 6.8 12 12 21 193.2 5.1 12 15 17 56.8 14.0 12 7 12 141.1 4.3 12 10 3 198.2 6.1 12 12 22 25.6 12.7 12 15 19 115.9 12.2 12 7 13 144.3 4.7 12 10 4 66.9 8.9 12 12 23 82.4 10.4 12 15 20 172.4 6.0 12 7 14 46.5 15.2 12 10 5 165.2 4.0 12 12 24 163.0 7.5 12 15 21 155.0 5.5 12 7 15 152.8 5.1 12 10 6 125.8 5.6 12 12 25 58.1 15.0 12 15 22 144.3 6.8 12 7 16 73.8 9.4 12 10 7 164.8 4.1 12 13 0 250.8 4.6 12 15 23 55.6 15.2 12 7 17 133.8 5.4 12 10 8 241.8 4.2 12 13 1 395.6 6.7 12 15 24 28.7 13.2 12 7 18 152.8 5.1 12 10 9 107.6 7.0 12 13 2 126.4 4.4 12 16 0 36.8 12.8 12 7 19 36.6 12.7 12 10 10 201.0 4.8 12 13 3 303.9 4.6 12 16 1 175.3 3.7 12 7 20 28.7 12.8 12 10 11 378.0 5.4 12 13 4 309.9 4.5 12 16 2 101.7 3.9 12 7 21 191.5 16.6 12 10 12 26.8 11.9 12 13 5 243.5 4.4 12 16 3 100.9 3.9 12 7 22 103.2 7.9 12 10 13 141.2 4.2 12 13 6 585.6 8.6 12 16 4 126.8 4.2 12 7 23 180.0 5.6 12 10 14 159.4 3.8 12 13 7 91.6 4.8 12 16 5 85.7 7.0 12 7 24 102.8 8.0 12 10 15 176.4 4.6 12 13 8 264.5 4.4 12 16 6 190.5 3.8 12 7 25 71.8 11.8 12 10 16 68.9 8.8 12 13 9 67.0 6.4 12 16 7 190.1 3.8 12 7 26 51.8 17.3 12 10 17 33.0 13.4 12 13 10 18.5 9.2 12 16 8 101.5 6.0 12 8 0 482.5 7.2 12 10 18 135.9 6.0 12 13 11 51.2 10.5 12 16 9 259.0 4.6 12 8 1 140.7 3.7 12 10 19 97.4 7.6 12 13 12 184.5 3.9 12 16 10 117.7 5.2 12 8 2 65.0 5.4 12 10 21 27.2 12.4 12 13 13 190.5 4.4 12 16 11 32.7 11.5 12 8 3 219.2 6.4 12 10 22 133.1 5.6 12 13 14 18.9 9.3 12 16 12 148.6 4.3 12 8 4 61.2 13.0 12 10 23 104.1 8.2 12 13 15 27.4 11.6 12 16 13 22.6 10.2 12 -8 5 185.8 4.1 12 10 24 85.8 10.5 12 13 16 199.4 4.8 12 16 14 36.9 11.9 12 8 6 222.9 5.0 12 10 25 44.4 17.8 12 13 17 65.7 8.8 12 16 15 114.5 4.5 12 8 7 17.8 8.8 12 10 26 101.4 8.2 12 13 18 93.4 6.7 12 16 16 91.2 7.5 12 8 8 241.9 5.0 12 11 0 203.4 5.4 12 13 19 122.0 23.7 12 16 17 54.9 10.3 12 8 9 149.3 4.6 12 11 1 286.5 8.3 12 13 21 242.0 4.6 12 16 18 350.7 11.6 12 8 10 375.9 5.9 12 11 2 238.3 4.5 12 13 22 145.7 6.5 12 16 19 72.9 9.5 12 8 11 232.7 4.4 12 11 3 142.6 6.5 12 13 23 111.7 7.7 12 16 20 138.1 5.7 12 8 12 321.5 5.0 12 11 4 233.3 4.9 12 13 24 89.6 10.6 12 16 21 41.1 15.6 12 8 13 60.2 12.8 12 11 5 24.8 11.2 12 13 25 30.0 13.2 12 16 22 45.6 13.9 12 8 14 161.6 6.6 12 11 6 83.0 6.2 12 14 0 107.0 5.3 12 16 23 148.7 11.9 12 8 15 125.4 6.3 12 11 7 360.8 5.1 12 14 1 211.3 5.0 12 16 24 138.3 6.9 12 8 16 60.6 11.8 12 11 8 62.5 8.4 12 14 2 134.2 4.1 12 17 0 210.8 6.9 12 8 17 47.7 13.9 12 11 9 168.8 4.0 12 14 3 204.8 3.7 12 17 1 229.1 4.4 12 8 18 89.2 7.3 12 11 10 162.5 4.0 12 14 4 116.6 4.2 12 17 2 122.5 4.6 12 8 19 28.7 12.4 12 11 11 80.5 6.7 12 14 5 235.2 4.3 12 17 3 156.9 3.9 12 8 20 19.9 9.7 12 11 12 266.5 4.8 12 14 6 121.2 5.4 12 17 4 188.2 4.5 12 8 21 404.0 12.4 12 11 13 158.5 5.1 12 14 7 99.9 4.9 12 17 5 85.4 5.3 12 8 22 63.6 10.6 12 11 14 78.3 7.2 12 14 8 128.7 4.3 12 17 6 183.2 3.6 12 8 23 76.3 9.6 12 11 15 118.5 4.9 12 14 9 69.0 6.7 12 17 7 204.1 3.9 12 8 24 54.9 15.9 12 11 16 150.2 4.5 12 14 10 28.9 11.2 12 17 8 201.4 3.9 12 8 25 33.4 14.5 12 11 17 70.8 9.1 12 14 11 239.4 4.1 12 17 9 162.3 3.8 WO 99/10379 PCT/GB98/02542 -148 12 17 10 158.9 3.8 12 20 10 96.9 6.1 12 23 15 128.8 6.0 12 27 8 57.5 11.4 12 17 11 64.7 7.0 12 20 11 14.4 7.3 12 23 16 97.5 6.9 12 27 9 167.9 4.3 12 17 12 95.1 5.3 12 20 12 96.5 7.1 12 23 17 132.9 5.0 12 27 10 117.8 4.3 12 17 13 56.3 11.8 12 20 13 115.0 5.9 12 23 18 128.3 5.2 12 27 11 145.0 4.4 12 17 14 139.9 6.2 12 20 14 74.2 7.3 12 23 19 31.9 13.7 12 27 12 103.8 9.5 12 17 15 18.9 9.2 12 20 15 163.6 13.0 12 23 20 74.5 12.1 12 27 13 82.8 7.9 12 17 16 95.0 7.3 12 20 16 140.2 6.7 12 24 0 185.1 4.8 12 27 14 70.5 8.4 12 17 17 36.6 15.7 12 20 17 129.0 5.3 12 24 1 192.2 5.2 12 27 15 239.2 4.9 12 17 18 17.5 8.8 12 20 18 19.1 9.4 12 24 2 116.7 4.1 12 27 16 52.6 11.8 12 17 19 20.7 10.4 12 20 19 74.8 11.6 12 24 3 165.8 3.7 12 27 17 57.2 11.9 12 17 20 113.1 7.6 12 20 20 50.2 13.8 12 24 4 162.0 3.9 12 28 0 80.2 16.1 12 17 21 74.4 10.7 12 20 21 63.4 11.4 12 24 5 93.6 4.8 12 28 2 81.5 7.4 12 17 22 37.9 15.2 12 20 22 70.0 13.3 12 24 6 52.7 8.4 12 28 3 160.4 12.1 12 17 23 30.1 13.9 12 21 0 156.6 3.8 12 24 7 94.5 5.2 12 28 4 192.6 8.4 12 17 24 67.3 17.6 12 21 1 118.8 3.8 12 24 8 312.0 5.3 12 28 5 105.2 20.9 12 18 0 23.4 9.8 12 21 2 161.9 4.1 12 24 9 62.4 7.8 12 28 6 144.6 5.6 12 18 1 137.6 4.1 12 21 3 226.8 3.9 12 24 10 87.8 5.9 12 28 7 34.9 12.4 12 18 2 33.4 10.4 12 21 4 164.9 5.0 12 24 11 88.9 23.8 12 28 8 225.2 4.4 12 18 3 131.4 3.7 12 21 5 47.4 10.8 12 24 12 20.8 10.2 12 28 9 98.0 5.5 12 18 4 203.4 5.9 12 21 7 103.1 4.4 12 24 13 62.1 10.0 12 28 10 129.5 4.8 12 18 5 44.7 10.9 12 21 8 228.9 4.0 12 24 14 88.4 7.1 12 28 11 184.8 4.3 12 18 6 249.1 4.2 12 21 9 95.8 5.2 12 24 15 137.3 5.0 12 28 12 182.9 5.3 12 18 7 125.4 4.0 12 21 10 89.8 5.3 12 24 16 112.6 6.0 12 28 13 75.3 8.8 12 18 8 130.3 4.4 12 21 11 108.1 4.9 12 24 17 67.7 10.8 12 28 14 118.7 7.0 12 18 9 58.9 8.0 12 21 12 120.8 5.6 12 24 18 173.1 5.3 12 28 15 132.5 5.7 12 18 10 202.8 3.8 12 21 13 128.7 4.9 12 24 19 161.0 6.3 12 28 16 55.9 12.1 12 18 11 147.9 4.6 12 21 14 22.9 11.6 12 24 20 70.3 13.6 12 29 0 174.5 5.2 12 18 12 150.6 4.5 12 21 15 102.4 13.3 12 25 0 90.5 8.0 12 29 1 192.8 6.7 12 18 13 142.3 4.9 12 21 16 30.5 12.3 12 25 1 19.1 9.5 12 29 2 121.5 4.5 12 18 14 122.8 5.5 12 21 17 40.2 14.3 12 25 2 65.8 5.0 12 29 3 128.2 4.2 12 18 15 25.6 11.7 12 21 18 163.3 5.2 12 25 3 32.3 9.4 12 29 4 108.2 3.4 12 18 16 25.3 11.8 12 21 19 171.1 5.9 12 25 4 15.6 7.4 12 29 5 71.6 5.2 12 18 17 268.2 20.2 12 21 20 75.7 10.9 12 25 5 241.6 4.5 12 29 6 101.8 4.1 12 18 18 28.4 12.0 12 21 21 121.6 7.1 12 25 6 214.4 4.4 12 29 7 59.8 6.0 12 18 19 31.7 12.7 12 21 22 57.8 22.9 12 25 7 207.7 4.1 12 29 8 75.0 8.2 12 18 20 66.8 14.4 12 22 0 149.4 5.1 12 25 8 131.2 5.0 12 29 9 34.3 12.8 12 18 21 168.3 5.6 12 22 1 152.0 3.9 12 25 9 16.4 8.3 12 29 10 104.5 5.1 12 18 22 27.0 13.2 12 22 2 79.8 5.4 12 25 10 277.0 18.0 12 29 11 212.1 4.9 12 18 23 19.2 9.7 12 22 3 145.8 3.8 12 25 11 15.0 7.6 12 29 12 27.3 12.8 12 19 0 62.0 10.3 12 22 4 150.0 3.1 12 25 12 112.0 5.2 12 29 13 48.2 15.3 12 19 1 205.0 4.1 12 22 5 116.1 3.7 12 25 13 239.6 4.6 12 29 14 93.8 6.2 12 19 2 126.9 4.0 12 22 6 211.1 3.6 12 25 14 207.1 6.7 12 29 15 107.7 6.0 12 19 3 202.3 4.1 12 22 7 139.9 3.7 12 25 15 79.7 8.8 12 30 0 67.0 4.5 12 19 4 159.9 4.6 12 22 8 178.6 3.7 12 25 16 197.9 4.5 12 30 1 182.0 5.6 12 19 5 63.4 7.4 12 22 9 219.7 3.8 12 25 17 34.2 12.4 12 30 2 96.5 7.5 12 19 6 25.4 11.0 12 22 10 126.3 4.6 12 25 18 22.9 11.1 12 30 3 18.2 9.0 12 19 7 144.1 3.6 12 22 11 98.8 4.8 12 25 19 168.8 7.9 12 30 4 27.9 11.0 12 19 8 38.2 11.9 12 22 12 135.1 5.0 12 26 0 118.4 6.4 12 30 5 100.8 4.8 12 19 9 176.4 3.6 12 22 13 114.7 8.1 12 26 1 141.6 3.8 12 30 6 89.9 10.7 12 19 10 204.6 4.2 12 22 14 228.3 9.6 12 26 2 192.3 5.5 12 30 7 133.4 4.8 12 19 11 79.5 5.6 12 22 15 19.1 9.2 12 26 3 145.2 7.5 12 30 8 147.5 4.2 12 19 12 53.8 10.0 12 22 16 128.8 5.5 12 26 4 222.4 5.4 12 30 9 157.7 5.2 12 19 13 92.7 5.5 12 22 17 186.5 5.1 12 26 5 59.5 7.1 12 30 10 161.3 5.8 12 19 14 72.5 8.3 12 22 18 77.4 11.3 12 26 6 44.6 13.7 12 30 11 26.3 12.1 12 19 15 132.8 5.5 12 22 19 18.2 9.1 12 26 8 178.3 14.0 12 30 12 34.4 12.8 12 19 16 258.0 10.3 12 22 20 133.0 5.8 12 26 9 188.1 17.7 12 30 13 48.3 13.0 12 19 17 19.5 9.9 12 22 21 42.0 14.1 12 26 10 127.7 5.1 12 30 14 95.3 6.1 12 19 18 36.5 13.9 12 23 0 115.8 3.2 12 26 11 39.1 12.4 12 31 0 104.1 7.0 12 19 19 90.3 7.6 12 23 1 125.5 3.2 12 26 12 40.5 12.4 12 31 1 98.9 5.0 12 19 20 37.5 13.7 12 23 2 57.8 5.9 12 26 13 54.5 12.2 12 31 2 36.1 12.6 12 19 21 28.3 12.9 12 23 3 135.4 3.4 12 26 14 73.8 8.6 12 31 3 114.6 4.2 12 19 22 111.1 6.8 12 23 4 120.3 5.5 12 26 15 126.7 6.7 12 31 4 82.7 7.9 12 19 23 23.5 11.7 12 23 5 88.5 4.2 12 26 16 96.0 6.6 12 31 5 81.7 7.9 12 20 0 170.3 3.7 12 23 6 75.1 5.8 12 26 17 189.2 4.8 12 31 6 139.0 5.3 12 20 1 72.3 5.1 12 23 7 86.4 4.7 12 26 18 124.6 5.8 12 31 7 144.6 5.1 12 20 2 40.0 9.6 12 23 8 35.2 11.3 12 27 0 238.0 4.0 12 31 8 77.9 6.5 12 20 3 259.2 4.8 12 23 9 101.3 4.8 12 27 1 395.6 5.8 12 31 9 70.6 6.6 12 20 4 233.2 3.9 12 23 10 116.0 4.3 12 27 2 65.9 5.3 12 31 10 87.3 6.5 12 20 5 23.1 10.4 12 23 11 48.8 13.3 12 27 3 95.0 4.7 12 31 11 100.4 6.5 12 20 6 161.7 3.7 12 23 12 45.0 15.0 12 27 4 163.2 4.3 12 31 12 31.8 11.8 12 20 8 60.3 6.8 12 23 13 215.7 21.4 12 27 5 33.7 14.0 12 31 13 77.7 7.8 12 20 9 116.2 5.0 12 23 14 239.6 4.3 12 27 6 193.6 9.5 12 32 0 220.7 7.3 WO 99/10379 PCT/GB98/02542 -149 12 32 1 50.7 9.3 13 1 12 161.2 6.9 13 4 5 389.5 6.2 13 7 0 175.9 3.9 12 32 2 111.6 5.1 13 1 13 54.6 13.5 13 4 6 168.8 4.4 13 7 1 98.8 4.4 12 32 3 132.4 9.6 13 1 14 196.4 3.9 13 4 7 374.7 5.5 13 7 2 138.6 4.7 12 32 4 97.3 7.4 13 1 15 102.5 8.2 13 4 8 220.8 4.3 13 7 3 261.7 5.0 12 32 5 111.7 3.8 13 1 16 26.0 12.3 13 4 9 217.9 5.1 13 7 4 242.6 5.3 12 32 6 93.1 4.6 13 1 17 106.6 6.5 13 4 10 228.2 4.7 13 7 5 230.7 4.4 12 32 7 90.7 4.7 13 1 18 170.9 5.4 13 4 11 127.6 4.5 13 7 6 196.3 4.3 12 32 8 90.6 7.1 13 1 19 112.8 8.0 13 4 12 127.9 5.5 13 7 7 26.3 12.8 12 32 9 112.0 5.5 13 1 20 143.4 20.6 13 4 13 171.6 4.4 13 7 8 19.3 9.4 12 32 10 70.6 6.6 13 1 21 26.1 12.9 13 4 14 138.8 4.6 13 7 9 152.2 5.0 12 32 11 83.0 6.8 13 1 22 76.6 14.2 13 4 15 74.6 8.2 13 7 10 96.0 5.9 12 33 0 76.0 5.6 13 1 23 128.7 9.1 13 4 16 175.2 4.4 13 7 11 115.7 7.0 12 33 1 149.2 5.6 13 1 24 143.7 6.9 13 4 17 72.6 8.1 13 7 12 254.2 4.4 12 33 2 90.4 5.0 13 125 74.8 12.4 13 4 18 159.0 4.8 13 7 13 182.7 4.3 12 33 3 169.6 3.9 13 1 26 20.6 10.4 13 4 19 21.1 10.6 13 7 14 230.8 4.8 12 33 4 146.3 7.9 13 2 0 323.0 5.1 13 4 20 373.2 14.4 13 7 15 211.3 5.1 12 33 5 50.6 16.4 13 2 1 496.1 6.8 13 4 21 137.0 6.2 13 7 16 111.5 5.7 12 33 6 23.0 10.8 13 2 2 175.6 5.6 13 4 22 48.3 16.5 13 7 17 134.8 5.6 12 33 7 113.3 5.4 13 2 3 241.0 4.2 13 4 23 190.4 5.9 13 7 18 81.3 11.8 12 33 8 64.1 8.5 13 2 4 93.7 7.8 13 4 24 38.4 16.8 13 7 21 55.8 15.2 12 33 9 100.6 6.8 13 2 5 97.3 5.3 13 4 25 69.6 15.5 13 7 22 67.2 12.8 12 34 0 48.1 13.4 13 2 6 210.2 5.2 13 4 26 72.3 13.8 13 7 23 159.3 8.7 12 34 1 114.4 7.9 13 2 7 30.4 13.2 13 5 0 164.3 5.9 13 7 24 83.5 10.8 12 34 2 77.9 8.4 13 2 8 168.6 5.8 13 5 1 183.3 5.9 13 7 25 46.7 17.0 12 34 3 33.4 11.9 13 2 9 184.1 4.0 13 5 2 57.4 7.5 13 8 0 317.3 8.8 12 34 4 121.8 6.0 13 2 10 127.1 6.3 13 5 3 183.3 6.1 13 8 1 254.5 4.9 12 34 5 73.6 7.6 13 2 11 173.2 4.3 13 5 4 153.0 6.2 13 8 2 173.1 4.1 12 34 6 107.2 9.4 13 2 12 208.6 5.9 13 5 5 292.1 4.7 13 8 3 94.3 4.9 12 34 7 13.6 6.9 13 2 13 181.5 4.1 13 5 6 202.2 4.0 13 8 4 174.9 4.9 12 35 0 182.4 5.2 13 2 14 36.1 12.0 13 5 7 219.4 4.3 13 8 5 345.4 5.6 12 35 1 36.9 13.0 13 2 15 199.6 4.9 13 5 8 33.7 13.5 13 8 6 247.6 5.2 12 35 2 122.8 5.5 13 2 16 108.3 6.1 13 5 9 179.5 4.7 13 8 7 63.6 7.9 12 35 3 21.9 10.2 13 2 17 101.8 7.1 13 5 10 70.0 7.6 13 8 8 99.0 6.6 12 35 4 53.8 8.0 13 2 18 40.8 16.0 13 5 11 83.7 7.1 13 8 9 245.3 4.2 13 0 0 456.7 9.7 13 2 19 47.9 15.3 13 5 12 86.8 8.7 13 8 10 247.8 4.1 13 0 1 378.7 7.8 13 2 20 221.5 10.4 13 5 13 79.8 7.2 13 8 11 161.9 4.6 13 0 2 265.8 9.4 13 2 21 40.9 15.4 13 5 14 100.5 5.5 13 8 12 71.9 8.1 13 0 3 100.0 17.5 13 2 22 86.7 10.0 13 5 15 33.1 12.9 13 8 13 90.9 8.9 13 0 4 39.5 19.7 13 2 23 136.7 9.4 13 5 16 236.0 4.3 13 8 14 92.4 5.8 13 0 5 192.1 5.7 13 2 24 89.2 10.4 13 5 17 73.1 9.4 13 8 15 224.8 5.6 13 0 6 67.0 17.2 13 2 25 34.9 15.7 13 5 18 59.5 11.6 13 8 16 132.7 6.9 13 0 7 48.6 21.0 13 2 26 61.5 15.1 13 5 19 106.2 6.3 13 8 17 23.1 10.7 13 0 8 243.7 6.3 13 3 0 481.9 6.9 13 5 20 387.5 11.8 13 8 18 92.7 8.9 13 0 9 63.7 14.6 13 3 1 114.6 4.6 13 5 21 72.3 9.8 13 8 19 131.7 12.7 13 0 10 47.8 21.2 13 3 2 306.7 4.8 13 5 22 49.9 16.8 13 8 20 84.0 12.0 13 0 11 73.0 14.2 13 3 3 72.5 6.2 13 5 23 50.1 17.0 13 8 21 50.5 16.7 13 0 12 204.3 6.6 13 3 4 106.3 6.7 13 5 24 104.0 9.7 13 8 22 130.4 6.4 13 0 13 172.4 6.3 13 3 5 258.4 4.8 13 5 25 65.7 18.1 13 8 23 78.3 18.8 13 0 14 89.8 9.1 13 3 6 227.9 4.5 13 6 0 208.2 4.1 13 8 24 79.9 16.7 13 0 15 45.9 20.7 13 3 7 39.9 13.6 13 6 1 273.1 6.5 13 8 25 85.4 17.2 13 0 16 149.3 6.4 13 3 8 89.7 7.8 13 6 2 128.2 4.7 13 9 0 221.3 4.8 13 -0 17 121.8 7.4 13 3 10 76.3 11.4 13 6 3 219.2 6.3 13 9 1 319.3 5.6 13 0 18 74.0 18.7 13 3 11 204.4 4.2 13 6 4 56.4 11.5 13 9 2 106.2 4.4 13 0 19 36.9 24.2 13 3 12 94.9 6.9 13 6 5 19.7 9.4 13 9 3 207.5 3.9 13 0 20 223.4 10.0 13 3 13 45.1 14.5 13 6 6 119.1 4.8 13 9 4 55.5 10.0 13 0 22 125.9 12.0 13 3 14 164.9 5.2 13 6 7 193.2 4.3 13 9 5 142.3 5.1 13 0 23 24.1 17.1 13 3 15 27.1 12.2 13 6 9 20.5 9.9 13 9 6 281.7 5.1 13 0 24 128.0 10.9 13 3 16 86.6 6.7 13 6 10 61.0 9.1 13 9 7 30.1 12.2 13 0 25 205.5 14.7 13 3 17 82.0 8.0 13 6 11 93.7 7.4 13 9 8 137.2 4.9 13 0 26 130.6 17.5 13 3 18 75.9 8.8 13 6 12 133.3 6.0 13 9 9 99.3 5.8 13 1 0 266.9 4.4 13 3 19 23.1 11.2 13 6 13 229.5 4.4 13 9 10 55.6 14.0 13 1 1 205.2 3.8 13 3 20 202.2 15.3 13 6 14 108.1 5.6 13 9 11 72.4 8.4 13 1 2 256.4 5.3 13 3 22 107.9 7.9 13 6 15 19.2 9.4 13 9 12 117.9 5.2 13 1 3 380.7 5.7 13 3 23 166.5 6.6 13 6 16 60.3 11.3 13 9 13 218.3 4.3 13 1 4 22.6 11.2 13 3 24 86.0 11.0 13 6 17 101.3 7.4 13 9 14 62.8 12.2 13 1 5 103.2 5.1 13 3 25 47.4 15.7 13 6 18 57.8 12.2 13 9 15 145.1 4.6 13 1 6 340.9 5.6 13 3 26 53.4 15.5 13 6 20 168.2 15.6 13 9 16 130.5 5.7 13 1 7 20.6 10.4 13 4 0 188.4 4.8 13 6 21 35.1 14.3 13 9 17 78.0 7.7 13 1 8 327.4 5.1 13 4 1 107.3 5.3 13 6 22 113.3 7.6 13 9 18 41.6 12.7 13 1 9 48.8 11.7 13 4 2 156.2 4.2 13 6 23 42.3 16.1 13 9 19 379.2 10.5 13 1 10 108.5 6.4 13 4 3 216.4 6.6 13 6 24 141.3 7.7 13 9 20 40.2 16.0 13 1 11 64.7 12.8 13 4 4 317.0 4.8 13 6 25 55.8 18.9 13 9 21 33.1 15.2 WO 99/10379 PCT/GB98/02542 -150 13 9 22 112.5 8.1 13 12 17 70.7 11.3 13 15 18 142.2 8.1 13 18 20 39.1 15.2 13 9 23 140.9 9.4 13 12 18 444.3 12.1 13 15 19 196.6 5.1 13 18 21 119.0 7.8 13 9 24 26.5 12.4 13 12 19 93.5 6.8 13 15 20 152.9 6.2 13 18 22 184.9 6.8 13 9 25 26.2 12.8 13 12 20 72.4 11.0 13 15 21 35.8 15.9 13 19 0 229.2 3.8 13 10 0 170.9 3.5 13 12 21 106.1 7.3 13 15 22 47.9 15.7 13 19 1 103.5 4.8 13 10 1 206.2 3.8 13 12 22 117.4 9.3 13 15 23 22.6 11.1 13 19 2 205.2 3.6 13 10 2 316.5 5.2 13 12 23 79.7 10.9 13 16 0 164.8 4.1 13 19 3 150.4 3.5 13 10 3 173.9 4.5 13 12 24 85.4 9.9 13 16 1 55.9 6.5 13 19 4 114.7 7.5 13 10 4 75.4 8.0 13 13 0 225.0 5.8 13 16 2 105.9 4.2 13 19 5 112.0 3.9 13 10 5 356.4 5.1 13 13 1 159.5 4.8 13 16 3 99.4 8.3 13 19 6 71.2 6.2 13 10 6 19.0 9.3 13 13 2 147.5 4.0 13 16 4 20.2 9.1 13 19 7 123.8 4.9 13 10 7 15.2 7.6 13 13 3 231.6 4.6 13 16 5 210.9 4.0 13 19 8 96.3 6.5 13 10 8 134.8 5.1 13 13 4 312.2 4.8 13 16 6 212.8 4.5 13 19 9 26.6 11.1 13 10 9 132.1 5.4 13 13 5 162.1 4.2 13 16 7 24.3 10.4 13 19 10 104.7 5.3 13 10 10 157.0 5.2 13 13 6 109.5 4.4 13 16 8 92.7 7.1 13 19 11 123.5 4.8 13 10 11 70.0 6.5 13 13 7 169.0 3.9 13 16 9 125.4 4.4 13 19 12 78.7 8.7 13 10 12 84.5 7.3 13 13 8 54.4 10.6 13 16 10 108.3 5.0 13 19 13 23.0 10.7 13 10 13 79.5 7.9 13 13 9 27.0 11.7 13 16 11 153.1 4.9 13 19 14 410.5 15.3 13 10 14 93.8 8.7 13 13 10 109.6 6.1 13 16 12 111.6 6.0 13 19 15 26.8 12.2 13 10 15 24.5 11.5 13 13 11 183.8 4.3 13 16 14 111.0 6.3 13 19 16 29.1 12.8 13 10 16 76.2 9.8 13 13 12 247.6 4.1 13 16 15 107.3 6.8 13 19 17 114.7 6.7 13 10 17 180.8 4.7 13 13 13 50.6 10.9 13 16 16 380.9 10.4 13 19 18 29.0 13.2 13 10 18 86.9 8.9 13 13 14 89.5 6.8 13 16 17 113.5 6.5 13 19 19 80.4 12.8 13 10 19 272.1 16.4 13 13 15 54.2 11.8 13 16 18 124.1 6.1 13 19 20 39.5 14.6 13 10 20 127.2 9.4 13 13 16 33.4 13.1 13 16 19 65.8 12.3 13 19 21 130.7 7.2 13 10 21 159.0 6.9 13 13 17 26.0 12.1 13 16 20 148.0 8.9 13 20 0 168.4 3.4 13 10 22 139.9 8.1 13 13 18 64.2 22.0 13 16 21 45.5 15.2 13 20 1 164.1 4.2 13 10 23 137.1 7.0 13 13 19 96.4 8.2 13 16 22 93.0 12.0 13 20 2 256.6 4.3 13 10 24 35.1 16.1 13 13 20 33.6 14.5 13 16 23 93.3 11.4 13 20 3 13.1 6.5 13 10 25 27.6 13.4 13 13 21 220.5 5.5 13 17 0 15.7 7.6 13 20 4 228.1 3.8 13 11 0 16.8 7.9 13 13 22 157.1 5.8 13 17 1 86.2 9.0 13 20 5 105.7 5.0 13 11 1 34.1 10.6 13 13 23 37.4 16.4 13 17 2 327.7 5.6 13 20 6 167.4 4.4 13 11 2 329.8 6.7 13 13 24 39.9 16.4 13 17 3 197.9 3.7 13 20 7 60.0 7.0 13 11 3 69.4 8.1 13 14 0 110.7 3.7 13 17 4 209.2 4.0 13 20 8 114.8 5.1 13 11 4 55.9 10.4 13 14 1 164.1 4.3 13 17 5 17.0 8.3 13 20 9 156.4 4.9 13 11 5 56.2 10.9 13 14 2 46.6 10.9 13 17 6 243.1 4.2 13 20 10 121.3 6.3 13 11 6 36.8 13.3 13 14 3 79.1 4.6 13 17 7 223.8 4.1 13 20 11 149.4 5.2 13 11 7 41.9 13.7 13 14 4 144.8 4.5 13 17 8 127.2 4.4 13 20 12 37.8 14.7 13 11 8 137.0 4.8 13 14 5 30.4 11.3 13 17 9 169.0 3.9 13 20 13 235.2 15.2 13 11 9 86.2 6.0 13 14 7 132.5 3.9 13 17 10 129.4 5.0 13 20 14 126.8 5.8 13 11 10 173.2 4.8 13 14 8 147.0 4.0 13 17 11 173.3 4.9 13 20 15 79.4 9.1 13 11 11 18.6 9.0 13 14 9 93.2 5.4 13 17 12 70.8 8.6 13 20 16 217.9 4.3 13 11 12 245.7 5.0 13 14 10 79.1 7.6 13 17 13 137.3 6.5 13 20 17 108.7 9.5 13 11 13 94.4 6.9 13 14 11 78.1 7.4 13 17 14 87.3 6.0 13 20 18 116.5 7.9 13 11 14 128.1 5.2 13 14 12 104.8 5.4 13 17 15 32.7 14.8 13 20 19 110.7 6.7 13 11 15 35.9 14.2 13 14 13 152.7 4.3 13 17 16 200.7 7.0 13 20 20 110.6 9.9 13 11 16 174.0 6.1 13 14 14 117.9 5.2 13 17 17 189.5 5.2 13 21 0 185.7 3.6 13 11 17 117.3 8.2 13 14 15 84.0 7.1 13 17 18 175.2 4.7 13 21 1 203.2 3.5 13 11 18 158.7 11.4 13 14 16 66.5 10.9 13 17 19 120.0 5.8 13 21 2 17.5 8.7 13 11 19 19.6 9.9 13 14 17 292.6 10.7 13 17 20 153.9 6.5 13 21 3 87.3 4.3 13 11 20 128.2 6.6 13 14 19 65.3 10.5 13 17 21 146.7 5.9 13 21 4 69.2 5.3 13 411 21 96.9 9.3 13 14 20 120.5 7.2 13 17 22 31.4 13.9 13 21 5 102.8 5.0 13 11 22 153.3 7.1 13 14 21 193.1 7.1 13 18 0 320.8 4.4 13 21 6 89.3 5.1 13 11 23 116.2 8.4 13 14 22 35.5 14.8 13 18 1 191.3 3.9 13 21 7 271.5 4.4 13 11 24 102.5 9.0 13 14 23 137.8 8.3 13 18 2 144.5 3.4 13 21 8 223.4 4.8 13 12 0 191.3 4.3 13 15 0 140.2 3.8 13 18 3 202.5 7.6 13 21 9 105.9 4.7 13 12 1 139.9 4.2 13 15 1 85.8 7.2 13 18 4 39.1 8.6 13 21 10 207.5 4.4 13 12 2 80.3 5.1 13 15 2 181.1 4.6 13 18 5 132.9 5.9 13 21 11 74.0 8.0 13 12 3 35.4 10.1 13 15 3 69.6 6.0 13 18 6 100.5 5.4 13 21 13 25.8 11.9 13 12 4 217.6 4.6 13 15 4 113.6 5.0 13 18 7 151.3 4.1 13 21 14 137.4 6.3 13 12 5 198.9 4.7 13 15 5 18.4 9.0 13 18 8 130.4 4.4 13 21 15 16.3 8.2 13 12 6 208.0 4.1 13 15 6 165.1 3.9 13 18 9 260.2 4.3 13 21 16 67.3 10.8 13 12 7 171.5 4.1 13 15 7 197.2 5.3 13 18 10 92.0 6.0 13 21 17 94.1 7.5 13 12 8 165.5 5.0 13 15 8 108.3 4.9 13 18 11 160.7 3.9 13 21 18 115.9 8.6 13 12 9 103.9 6.4 13 15 9 38.4 12.2 13 18 12 87.2 6.4 13 21 19 33.0 15.0 13 12 10 99.1 5.1 13 15 10 88.7 6.1 13 18 13 88.8 7.6 13 21 20 23.7 11.2 13 12 11 109.3 5.8 13 15 11 93.6 5.3 13 18 14 47.5 14.2 13 22 0 219.6 5.1 13 12 12 199.3 4.8 13 15 12 127.9 6.6 13 18 15 395.1 14.0 13 22 1 106.0 3.8 13 12 13 121.1 5.6 13 15 13 99.6 5.3 13 18 16 38.6 13.3 13 22 2 101.4 7.5 13 12 14 202.6 4.3 13 15 14 194.2 4.6 13 18 17 131.2 6.1 13 22 3 75.2 5.0 13 12 15 28.9 12.7 13 15 15 19.5 9.6 13 18 18 96.2 12.0 13 22 4 212.4 4.3 13 12 16 99.4 6.9 13 15 17 376.3 39.7 13 18 19 144.4 6.9 13 22 5 179.1 4.9 WO 99/10379 PCT/GB98/02542 -151 13 22 6 152.6 4.1 13 26 7 90.2 6.7 13 31 5 53.2 17.1 14 1 24 47.7 16.8 13 22 7 88.4 5.3 13 26 8 158.5 4.2 13 31 6 154.3 3.6 14 2 0 270.1 4.4 13 22 8 142.3 4.4 13 26 9 96.3 6.3 13 31 7 104.3 4.1 14 2 1 240.4 4.2 13 22 9 80.8 6.8 13 26 10 73.8 9.4 13 31 8 20.9 9.3 14 2 2 26.9 11.1 13 22 10 24.0 11.1 13 26 11 96.0 6.4 13 31 9 83.8 6.9 14 2 3 175.8 6.8 13 22 12 22.0 10.9 13 26 12 95.4 7.7 13 31 10 92.7 6.8 14 2 4 145.0 4.4 13 22 13 26.4 12.5 13 26 13 37.3 13.3 13 32 0 137.7 3.8 14 2 5 49.7 13.8 13 22 14 148.7 5.4 13 26 14 129.3 8.7 13 32 1 64.2 12.8 14 2 6 100.0 8.0 13 22 15 117.7 10.2 13 26 15 117.7 6.0 13 32 2 63.1 7.1 14 2 7 144.2 4.8 13 22 16 153.2 5.0 13 26 16 69.1 11.3 13 32 3 29.6 13.0 14 2 8 104.9 6.8 13 22 17 27.9 13.8 13 27 0 256.1 19.6 13 32 4 60.1 6.7 14 2 9 80.3 6.4 13 22 18 89.3 7.3 13 27 1 153.0 14.9 13 32 5 123.1 11.0 14 2 10 121.6 5.8 13 22 19 193.8 5.7 13 27 2 83.4 27.3 13 32 6 102.4 7.7 14 2 11 26.4 12.1 13 23 0 166.3 3.2 13 27 3 188.4 4.6 13 32 7 172.4 5.4 14 2 12 128.4 5.5 13 23 1 196.7 3.5 13 27 4 70.0 6.6 13 32 8 42.7 13.5 14 2 13 68.1 8.6 13 23 2 131.3 6.2 13 27 5 38.6 14.9 13 33 0 81.6 5.3 14 2 14 113.8 7.0 13 23 3 155.9 5.7 13 27 6 17.3 8.0 13 33 1 123.7 7.1 14 2 15 114.4 5.5 13 23 4 147.8 3.3 13 27 7 139.6 5.3 13 33 2 45.0 10.6 14 2 16 124.4 8.5 13 23 5 88.6 4.2 13 27 8 92.2 6.2 13 33 3 162.3 8.4 14 2 17 28.5 12.9 13 23 6 186.7 4.1 13 27 9 218.1 5.5 13 33 4 33.2 11.5 14 2 18 20.2 10.2 13 23 7 109.6 5.5 13 27 10 74.1 7.7 13 33 5 104.6 5.1 14 2 19 27.2 13.7 13 23 8 168.4 4.1 13 27 11 106.9 8.9 13 33 6 128.7 6.2 14 2 20 92.3 13.0 13 23 9 259.2 4.9 13 27 12 160.5 5.1 13 34 0 79.7 5.2 14 2 21 96.0 9.8 13 23 12 80.7 6.1 13 27 13 42.9 14.3 13 34 1 51.5 12.5 14 2 22 27.4 13.7 13 23 13 121.3 4.8 13 27 14 164.8 4.6 13 34 2 26.5 12.0 14 2 23 20.1 10.0 13 23 14 61.9 13.1 13 27 15 23.9 11.1 14 0 0 44.4 24.9 14 2 24 69.7 14.1 13 23 15 54.9 13.7 13 28 0 165.9 5.8 14 0 1 235.7 6.2 14 3 0 162.1 3.8 13 23 16 26.2 12.6 13 28 1 113.7 4.7 14 0 2 19.8 13.1 14 3 1 273.1 5.1 13 23 17 102.3 7.0 13 28 2 68.3 5.9 14 0 3 161.5 11.6 14 3 2 85.2 5.9 13 23 18 87.4 11.8 13 28 3 224.3 5.2 14 0 4 54.3 17.5 14 3 3 218.9 6.2 13 23 19 63.2 18.7 13 28 4 89.2 4.2 14 0 5 17.5 12.6 14 3 4 249.3 4.4 13 24 0 21.9 9.8 13 28 5 111.9 5.4 14 0 6 101.3 14.5 14 3 5 253.9 4.7 13 24 1 104.2 4.9 13 28 6 47.0 10.4 14 0 7 176.0 6.4 14 3 6 25.6 11.9 13 24 2 101.1 5.6 13 28 7 103.9 5.6 14 0 8 27.4 17.1 14 3 7 119.2 6.5 13 24 3 132.7 3.6 13 28 8 79.9 6.2 14 0 9 177.4 5.8 14 3 8 185.0 5.7 13 24 4 114.0 6.9 13 28 9 60.4 12.4 14 0 10 197.3 6.4 14 3 9 41.5 13.9 13 24 5 74.8 6.4 13 28 10 154.0 6.7 14 0 11 101.0 10.7 14 3 10 91.2 7.7 13 24 6 65.2 6.5 13 28 11 45.0 13.0 14 0 12 146.7 9.5 14 3 11 200.2 5.5 13 24 7 124.4 4.4 13 28 12 89.9 6.9 14 0 13 184.1 6.8 14 3 12 210.6 4.2 13 24 9 131.0 25.5 13 28 13 56.2 11.1 14 0 14 167.9 8.3 14 3 13 143.7 5.6 13 24 10 81.1 7.9 13 28 14 26.9 11.9 14 0 15 20.9 15.1 14 3 14 131.0 5.8 13 24 11 60.0 12.4 13 29 0 120.6 3.6 14 0 16 60.5 22.1 14 3 15 58.2 12.0 13 24 12 90.8 7.8 13 29 1 254.3 6.5 14 0 17 177.1 12.0 14 3 16 169.6 4.8 13 24 13 78.4 10.1 13 29 2 56.7 11.0 14 0 19 16.2 12.1 14 3 17 36.8 14.5 13 24 14 107.4 7.5 13 29 3 114.7 5.2 14 0 20 46.4 22.3 14 3 18 55.8 21.0 13 24 15 143.3 5.1 13 29 4 83.8 9.5 14 0 21 94.2 15.5 14 3 20 25.2 12.1 13 24 16 119.4 6.2 13 29 5 146.1 3.8 14 0 22 183.2 10.0 14 3 21 33.2 14.3 13 24 17 79.5 9.6 13 29 6 237.9 5.3 14 0 23 135.0 9.5 14 3 22 158.6 9.7 13 24 18 52.9 14.1 13 29 7 140.9 4.1 14 0 24 52.7 25.5 14 3 23 101.8 9.4 13 25 0 83.4 9.2 13 29 8 232.0 4.4 14 1 0 159.0 4.2 14 3 24 107.2 9.5 13 25 1 183.5 3.2 13 29 9 73.1 8.7 14 1 1 77.3 5.2 14 4 0 220.1 3.9 13 25 2 119.3 3.8 13 29 10 19.1 9.5 14 1 2 244.8 5.1 14 4 1 340.3 8.3 13 25 3 184.5 5.2 13 29 11 80.1 7.6 14 1 3 155.2 7.4 14 4 2 129.9 5.7 13 25 4 94.7 4.1 13 29 12 77.2 8.8 14 1 4 141.8 4.8 14 4 3 56.2 6.9 13 25 5 60.2 12.5 13 29 13 32.4 14.1 14 1 6 181.8 4.6 14 4 4 82.6 7.9 13 25 6 223.7 9.8 13 30 0 144.7 6.2 14 1 7 93.4 7.4 14 4 5 211.3 4.3 13 25 8 46.8 13.7 13 30 1 93.7 3.9 14 1 8 182.2 4.2 14 4 6 98.5 7.2 13 25 9 193.6 4.9 13 30 2 110.1 5.1 14 1 9 262.3 4.6 14 4 7 394.3 5.9 13 25 10 34.9 13.2 13 30 3 71.5 6.5 14 1 10 205.3 4.6 14 4 8 114.0 5.7 13 25 11 99.4 6.1 13 30 4 109.3 3.9 14 1 11 91.1 9.6 14 4 9 115.9 5.6 13 25 12 158.1 4.7 13 30 5 62.2 13.3 14 1 12 85.6 9.9 14 4 10 195.6 4.6 13 25 13 185.7 4.5 13 30 6 193.4 4.8 14 1 13 180.9 4.3 14 4 11 124.4 5.3 13 25 14 67.5 9.4 13 30 7 166.3 5.4 14 1 14 112.5 6.3 14 4 12 135.1 5.8 13 25 15 60.7 12.7 13 30 8 66.9 9.0 14 1 15 97.5 7.0 14 4 13 32.7 13.9 13 25 16 102.2 7.4 13 30 9 28.2 11.0 14 1 16 151.5 5.9 14 4 14 87.1 8.5 13 25 17 30.1 12.6 13 30 11 159.1 5.6 14 1 17 215.2 5.9 14 4 15 108.7 6.0 13 26 0 134.0 3.6 13 30 12 41.7 14.3 14 1 18 100.5 9.2 14 4 16 73.2 9.7 13 26 1 24.8 10.3 13 31 0 160.1 4.4 14 1 19 20.6 10.4 14 4 17 174.1 6.1 13 26 2 223.8 5.6 13 31 1 91.7 8.9 14 1 20 96.1 9.9 14 4 18 141.7 13.0 13 26 3 73.9 21.2 13 31 2 510.8 34.7 14 1 21 94.3 11.3 14 4 19 57.2 16.6 13 26 4 312.8 13.2 13 31 3 95.6 4.3 14 1 22 123.3 9.0 14 4 20 182.6 5.2 13 26 5 154.8 9.5 13 31 4 81.3 5.0 14 1 23 28.5 13.4 14 4 21 109.8 9.6 WO 99/10379 PCT/GB98/02542 -152 14 4 22 80.4 11.2 14 7 20 34.5 14.5 14 10 22 179.7 8.0 14 14 2 149.8 4.3 14 4 23 111.2 10.0 14 7 21 153.7 9.7 14 10 23 132.0 11.7 14 14 3 51.1 6.8 14 4 24 87.5 12.0 14 7 22 107.1 9.6 14 11 0 177.2 6.2 14 14 4 44.2 14.3 14 5 0 111.7 4.1 14 7 23 53.2 17.4 14 11 1 302.5 4.8 14 14 5 137.2 4.8 14 5 1 297.2 5.4 14 8 0 107.0 5.6 14 11 2 171.1 5.3 14 14 6 123.6 4.3 14 5 2 52.7 11.0 14 8 1 53.0 10.0 14 11 3 304.1 4.9 14 14 7 68.9 7.3 14 5 3 221.4 4.7 14 8 2 73.0 5.8 14 11 4 183.8 7.7 14 14 8 105.1 5.7 14 5 4 217.4 6.0 14 8 3 24.4 10.5 14 11 5 177.0 4.6 14 14 9 125.6 4.5 14 5 5 243.3 4.5 14 8 4 151.9 8.8 14 11 6 185.1 4.2 14 14 10 95.2 5.7 14 5 6 154.8 4.6 14 8 5 47.6 11.9 14 11 7 52.6 10.3 14 14 11 63.1 13.4 14 5 7 137.7 6.1 14 8 6 115.1 5.6 14 11 8 154.6 4.9 14 14 12 131.2 5.4 14 5 8 158.9 4.3 14 8 7 148.5 5.5 14 11 9 49.1 11.3 14 14 13 26.8 12.7 14 5 9 186.3 4.3 14 8 8 139.3 4.6 14 11 10 48.6 10.3 14 14 14 48.8 14.2 14 5 10 161.0 4.6 14 8 9 99.2 6.5 14 11 11 151.8 4.5 14 14 15 388.0 12.5 14 5 11 125.0 5.3 14 8 10 111.2 7.0 14 11 12 73.0 9.2 14 14 17 164.0 5.4 14 5 12 159.8 5.5 14 8 11 121.9 6.1 14 11 13 145.9 5.5 14 14 18 114.9 7.0 14 5 13 95.7 7.3 14 8 12 207.9 4.4 14 11 14 48.2 12.2 14 14 19 96.0 8.9 14 5 14 38.6 13.4 14 8 13 216.4 4.3 14 11 15 29.5 12.9 14 14 20 30.5 13.9 14 5 15 69.0 9.5 14 8 14 148.7 6.2 14 11 17 83.5 14.9 14 14 21 28.5 13.2 14 5 16 28.7 13.5 14 8 15 26.2 11.8 14 11 18 172.5 7.1 14 14 22 139.2 8.3 14 5 17 119.5 7.5 14 8 16 141.1 5.8 14 11 19 80.7 11.7 14 15 0 26.7 10.6 14 5 18 319.0 14.4 14 8 19 29.8 12.9 14 11 20 102.9 10.8 14 15 1 68.9 9.0 14 5 19 135.5 6.6 14 8 20 129.0 6.9 14 11 21 145.7 6.7 14 15 2 134.7 4.8 14 5 20 61.3 12.4 14 8 21 87.3 10.2 14 11 22 27.5 13.1 14 15 3 65.6 7.1 14 5 21 94.5 10.8 14 8 22 49.1 19.0 14 12 0 143.8 3.4 14 15 4 53.3 10.0 14 5 22 186.0 6.2 14 8 23 58.4 14.4 14 12 1 29.0 11.4 14 15 5 98.6 7.6 14 5 23 63.3 18.6 14 8 24 100.6 9.5 14 12 2 81.8 4.8 14 15 6 181.9 4.8 14 5 24 61.0 16.9 14 9 0 187.9 3.9 14 12 3 244.8 5.6 14 15 7 99.9 5.2 14 6 0 142.1 6.7 14 9 1 160.1 4.2 14 12 4 111.1 4.7 14 15 8 40.7 11.3 14 6 1 157.5 3.8 14 9 2 85.9 6.6 14 12 5 142.4 4.3 14 15 9 82.5 6.7 14 6 2 154.7 3.8 14 9 3 122.4 4.0 14 12 6 79.9 6.5 14 15 10 104.4 5.9 14 6 4 108.6 6.6 14 9 4 224.0 4.6 14 12 7 83.5 6.5 14 15 11 143.5 4.3 14 6 5 156.4 5.1 14 9 5 121.3 4.3 14 12 8 67.8 9.4 14 15 12 127.6 6.2 14 6 6 134.0 5.3 14 9 6 249.6 4.5 14 12 9 21.1 10.4 14 15 13 18.0 9.0 14 6 7 59.6 11.9 14 9 7 87.3 6.5 14 12 10 173.2 4.2 14 15 14 106.0 12.9 14 6 8 50.4 11.5 14 9 8 23.6 10.7 14 12 11 72.1 9.8 14 15 16 121.8 6.9 14 6 9 115.6 4.9 14 9 9 95.4 8.0 14 12 12 52.7 13.3 14 15 17 84.7 9.9 14 6 10 51.2 11.1 14 9 10 38.3 13.9 14 12 13 202.3 4.2 14 15 18 70.5 13.4 14 6 11 202.3 4.5 14 9 11 127.3 4.8 14 12 14 153.4 6.0 14 15 19 122.0 7.7 14 6 12 38.8 13.5 14 9 12 77.6 8.1 14 12 15 37.3 15.0 14 15 20 76.7 11.7 14 6 13 243.4 4.9 14 9 13 133.1 4.7 14 12 16 406.6 15.8 14 15 21 48.8 15.6 14 6 14 97.7 8.9 14 9 14 47.3 11.7 14 12 17 35.3 14.0 14 16 0 176.1 3.4 14 6 15 48.2 14.4 14 9 15 82.8 8.6 14 12 18 136.9 6.0 14 16 1 79.6 6.4 14 6 16 180.5 4.5 14 9 16 169.1 4.3 14 12 19 187.1 7.5 14 16 2 95.8 4.5 14 6 17 24.9 11.7 14 9 17 290.6 14.9 14 12 20 196.4 7.4 14 16 3 167.8 4.1 14 6 18 294.8 9.7 14 9 18 54.4 17.7 14 12 21 113.8 8.9 14 16 4 107.6 4.4 14 6 19 152.1 6.8 14 9 19 148.4 6.9 14 12 22 129.0 8.3 14 16 5 62.8 6.4 14 6 20 18.7 9.4 14 9 20 119.6 7.0 14 12 23 79.9 27.4 14 16 6 170.5 4.8 14 6 21 89.6 9.9 14 9 21 147.2 5.9 14 13 0 209.5 3.7 14 16 7 132.8 4.4 14 6 22 98.4 9.9 14 9 22 80.6 13.0 14 13 1 178.0 4.4 14 16 8 112.6 6.5 14 6 23 54.7 18.9 14 9 23 109.0 8.3 14 13 2 140.2 4.4 14 16 9 205.0 4.3 14 -6 24 24.8 12.1 14 10 0 249.6 4.7 14 13 3 156.0 6.2 14 16 10 170.9 4.5 14 7 0 128.8 4.1 14 10 1 184.4 3.6 14 13 4 186.9 3.4 14 16 11 145.3 6.4 14 7 1 136.5 5.2 14 10 2 64.8 8.2 14 13 5 46.2 11.2 14 16 12 121.9 5.0 14 7 2 169.5 3.5 14 10 3 172.4 3.9 14 13 6 33.4 12.4 14 16 13 15.7 7.9 14 7 3 148.3 3.7 14 10 4 183.8 6.3 14 13 7 146.2 4.7 14 16 14 231.9 14.5 14 7 4 248.7 5.2 14 10 5 125.5 4.3 14 13 8 41.7 12.3 14 16 15 25.7 12.0 14 7 5 119.9 5.7 14 10 6 167.0 4.4 14 13 9 24.9 11.3 14 16 16 193.5 4.8 14 7 6 277.1 4.9 14 10 7 22.0 10.4 14 13 10 86.1 8.2 14 16 17 160.4 5.7 14 7 7 188.5 4.5 14 10 8 205.2 4.0 14 13 11 113.7 5.8 14 16 18 91.9 10.2 14 7 8 214.4 4.3 14 10 9 91.8 7.0 14 13 12 169.6 4.4 14 16 19 55.6 16.5 14 7 9 63.7 8.1 14 10 10 70.5 7.3 14 13 13 118.7 6.2 14 16 20 103.5 12.2 14 7 10 73.8 7.8 14 10 11 176.7 4.3 14 13 14 85.5 9.3 14 16 21 123.1 11.1 14 7 11 126.7 5.4 14 10 12 143.5 4.5 14 13 16 162.2 11.0 14 17 0 21.5 9.8 14 7 12 104.4 7.5 14 10 13 206.1 4.5 14 13 17 19.7 10.0 14 17 1 201.5 3.5 14 7 13 94.1 6.4 14 10 14 18.4 8.9 14 13 18 122.1 7.8 14 17 2 126.5 4.9 14 7 14 57.0 12.2 14 10 15 148.1 7.2 14 13 19 27.7 13.1 14 17 3 160.6 3.7 14 7 15 124.1 6.4 14 10 17 436.6 13.1 14 13 20 121.7 8.0 14 17 4 137.9 4.0 14 7 16 126.7 6.4 14 10 18 161.6 6.7 14 13 21 147.0 7.5 14 17 5 30.8 10.7 14 7 17 22.5 11.2 14 10 19 145.8 5.7 14 13 22 32.4 14.7 14 17 6 139.0 4.1 14 7 18 157.5 13.4 14 10 20 23.4 11.3 14 14 0 309.9 5.4 14 17 7 140.2 4.5 14 7 19 121.9 6.8 14 10 21 134.6 8.5 14 14 1 59.8 6.8 14 17 8 86.0 6.3 WO 99/10379 PCT/GB98/02542 -153 14 17 9 71.0 7.3 14 20 18 62.4 17.7 14 25 3 169.1 3.9 14 30 8 64.0 12.4 14 17 10 117.1 6.2 14 20 19 24.0 11.8 14 25 4 133.6 4.6 14 30 9 208.0 5.3 14 17 11 105.2 6.5 14 21 0 92.1 6.2 14 25 5 19.0 9.0 14 31 0 18.4 9.2 14 17 12 92.7 7.7 14 21 1 51.1 15.0 14 25 6 199.5 4.0 14 31 1 66.4 12.8 14 17 13 299.5 13.6 14 21 2 66.7 8.0 14 25 7 90.1 8.3 14 31 2 67.4 6.0 14 17 15 160.5 5.2 14 21 3 91.8 5.6 14 25 8 82.4 6.2 14 31 3 139.8 4.9 14 17 16 47.4 14.2 14 21 4 132.8 4.7 14 25 9 25.5 11.4 14 31 4 40.4 10.5 14 17 17 77.1 9.5 14 21 5 125.8 4.4 14 25 10 55.9 12.3 14 31 5 101.0 8.3 14 17 18 207.2 5.5 14 21 6 130.3 7.4 14 25 11 179.7 5.2 14 31 6 76.7 7.1 14 17 19 60.8 16.3 14 21 7 80.0 7.0 14 25 12 104.3 7.4 14 31 7 56.3 12.8 14 17 20 107.3 9.8 14 21 8 16.1 8.1 14 25 13 60.5 12.5 14 32 0 87.4 4.8 14 17 21 52.7 16.7 14 21 10 110.5 19.8 14 25 14 170.0 5.5 14 32 1 106.7 12.4 14 18 0 130.2 3.6 14 21 11 89.9 7.1 14 25 15 30.6 13.3 14 32 2 42.8 15.1 14 18 1 166.9 4.0 14 21 12 17.6 8.8 14 26 0 128.5 3.3 14 32 3 18.7 8.8 14 18 2 127.6 4.4 14 21 13 91.6 6.8 14 26 1 149.4 6.6 15 0 0 264.6 8.5 14 18 3 21.2 9.5 14 21 14 131.6 6.6 14 26 2 53.2 9.8 15 0 1 114.6 6.0 14 18 4 142.6 4.0 14 21 15 240.3 5.8 14 26 3 140.0 6.9 15 0 2 52.2 14.4 14 18 5 182.4 4.1 14 21 16 165.3 11.6 14 26 4 96.3 5.5 15 0 3 116.4 13.2 14 18 6 68.3 9.6 14 21 17 161.2 6.2 14 26 5 109.3 6.0 15 0 4 21.5 13.2 14 18 7 32.3 12.0 14 21 18 98.2 7.8 14 26 6 21.5 10.1 15 0 5 135.3 7.9 14 18 8 65.0 8.5 14 22 0 109.7 5.3 14 26 7 282.3 5.4 15 0 6 150.4 12.9 14 18 9 171.3 5.1 14 22 1 182.0 4.0 14 26 8 31.8 13.1 15 0 7 176.1 6.1 14 18 10 168.1 9.6 14 22 2 245.3 6.1 14 26 9 160.4 5.9 15 0 8 140.4 9.0 14 18 11 20.6 9.9 14 22 3 192.8 4.6 14 26 10 156.7 6.5 15 0 9 332.9 7.2 14 18 12 165.8 18.5 14 22 4 138.7 4.6 14 26 11 30.2 13.4 15 0 10 109.8 9.7 14 18 13 20.0 10.1 14 22 5 216.3 5.7 14 26 12 94.0 7.3 15 0 11 202.9 9.8 14 18 14 68.9 9.4 14 22 8 269.7 14.5 14 26 13 77.4 9.7 15 0 12 90.7 12.2 14 18 15 38.7 14.1 14 22 10 63.8 9.3 14 27 0 70.1 12.5 15 0 13 205.5 7.1 14 18 16 131.1 9.1 14 22 11 18.5 9.3 14 27 1 24.6 10.4 15 0 14 24.6 16.5 14 18 17 100.1 7.9 14 22 12 86.7 11.6 14 27 2 124.7 10.4 15 0 15 161.2 8.4 14 18 18 154.3 6.2 14 22 13 136.5 5.8 14 27 3 201.7 5.1 15 0 16 80.6 25.5 14 18 19 120.5 8.5 14 22 14 67.8 10.4 14 27 4 145.2 3.8 15 0 17 21.4 15.4 14 18 20 31.1 14.2 14 22 15 59.2 15.9 14 27 5 94.6 6.6 15 0 18 28.1 18.0 14 19 0 199.7 4.4 14 22 16 76.6 11.5 14 27 6 49.3 11.2 15 0 19 19.1 14.0 14 19 1 154.3 6.6 14 22 17 49.8 15.5 14 27 7 38.9 13.1 15 0 20 18.3 13.2 14 19 2 128.2 3.7 14 22 18 83.7 11.3 14 27 8 193.0 10.6 15 0 21 27.9 19.8 14 19 3 76.5 6.3 14 23 0 164.1 3.8 14 27 9 17.7 8.7 15 0 22 116.0 13.2 14 19 4 22.4 9.7 14 23 1 19.9 9.5 14 27 10 39.2 14.7 15 1 0 104.8 9.0 14 19 5 76.1 6.7 14 23 2 22.6 11.1 14 27 11 40.9 12.8 15 1 1 47.0 9.0 14 19 6 136.7 4.3 14 23 3 115.6 6.7 14 27 12 19.8 9.8 15 1 2 93.2 5.6 14 19 7 69.8 9.6 14 23 4 103.2 10.3 14 28 0 133.0 5.1 15 1 3 82.1 12.1 14 19 8 219.7 4.5 14 23 5 86.8 5.3 14 28 1 173.8 4.5 15 1 4 114.9 4.1 14 19 9 88.0 6.9 14 23 7 60.6 23.7 14 28 2 107.8 5.3 15 1 5 89.1 7.2 14 19 10 154.0 4.2 14 23 8 155.0 5.5 14 28 3 47.4 8.7 15 1 6 62.2 11.2 14 19 11 148.4 11.1 14 23 9 38.0 13.8 14 28 4 215.6 4.6 15 1 7 192.8 4.1 14 19 12 146.1 10.8 14 23 10 66.3 10.3 14 28 5 68.7 9.0 15 1 8 66.1 8.9 14 19 13 31.9 14.2 14 23 11 204.6 4.7 14 28 6 84.0 5.3 15 1 9 24.0 11.5 14 19 14 119.8 8.5 14 23 12 18.5 9.3 14 28 7 109.2 6.9 15 1 10 27.2 12.4 14 19 15 123.4 6.0 14 23 13 27.4 12.5 14 28 8 118.3 6.4 15 1 11 89.9 9.7 14 19 16 81.2 11.1 14 23 14 27.3 12.5 14 28 9 20.0 9.9 15 1 12 140.6 6.0 14 19 17 24.1 12.0 14 23 15 100.5 6.6 14 28 10 100.6 8.2 15 1 13 50.6 14.3 14 19 18 123.3 6.9 14 23 16 21.7 10.8 14 28 11 62.9 13.5 15 1 14 78.6 10.5 14 19 19 53.5 13.4 14 23 17 118.5 10.9 14 28 12 164.3 6.0 15 1 15 137.2 7.0 14 19 20 97.7 21.5 14 24 1 70.2 14.1 14 29 0 44.5 9.3 15 1 16 40.6 16.1 14 20 0 70.1 6.8 14 24 2 53.2 14.4 14 29 1 60.4 14.5 15 1 18 141.6 6.3 14 20 1 108.7 4.1 14 24 3 145.8 11.1 14 29 2 158.2 4.8 15 1 19 86.5 13.9 14 20 2 207.0 4.4 14 24 4 225.6 12.2 14 29 3 85.4 6.4 15 1 20 102.0 8.8 14 20 3 132.8 3.7 14 24 5 42.7 15.4 14 29 4 131.5 4.8 15 1 21 55.5 16.9 14 20 4 78.2 6.6 14 24 6 27.4 11.9 14 29 5 140.8 4.3 15 1 22 169.5 7.5 14 20 5 18.5 9.3 14 24 7 153.2 4.1 14 29 6 105.8 5.5 15 1 23 83.9 17.5 14 20 6 107.6 5.3 14 24 8 105.5 6.5 14 29 7 168.6 4.8 15 2 0 93.4 9.4 14 20 7 133.5 4.8 14 24 9 62.8 10.1 14 29 8 53.6 7.5 15 2 1 169.8 3.7 14 20 8 161.8 6.3 14 24 10 94.2 6.6 14 29 9 43.3 11.2 15 2 2 130.7 6.5 14 20 9 30.1 12.7 14 24 11 22.0 10.7 14 29 10 143.5 4.8 15 2 3 119.5 7.0 14 20 10 92.0 33.0 14 24 12 138.0 5.9 14 30 0 20.8 9.8 15 2 4 96.0 5.3 14 20 11 177.6 17.5 14 24 13 138.1 5.5 14 30 1 38.2 10.0 15 2 5 80.1 8.1 14 20 12 33.5 14.9 14 24 14 39.2 14.7 14 30 2 64.8 8.2 15 2 6 139.9 5.2 14 20 13 153.0 7.3 14 24 15 20.5 10.3 14 30 3 77.2 9.4 15 2 7 25.9 11.2 14 20 14 159.0 5.5 14 24 16 20.7 10.2 14 30 4 164.8 4.3 15 2 8 155.9 4.7 14 20 15 116.7 6.9 14 25 0 147.8 21.2 14 30 5 78.3 11.4 15 2 9 48.9 13.1 14 20 16 32.1 14.3 14 25 1 114.0 10.2 14 30 6 177.7 4.5 15 2 10 169.8 5.4 14 20 17 20.9 10.6 14 25 2 62.7 8.7 14 30 7 147.3 4.3 15 2 11 108.4 6.3 WO 99/10379 PCT/GB98/02542 -154 15 2 12 106.0 6.6 15 5 16 276.4 8.8 15 8 21 30.0 13.5 15 12 5 71.0 8.4 15 2 13 153.8 6.0 15 5 17 71.6 11.4 15 8 22 24.6 11.9 15 12 6 177.7 4.4 15 2 14 145.2 9.9 15 5 18 97.0 10.5 15 9 0 120.2 5.4 15 12 7 124.1 4.6 15 2 15 72.3 11.8 15 5 19 110.0 8.5 15 9 1 133.1 4.7 15 12 8 186.0 4.3 15 2 16 142.6 9.6 15 5 20 121.6 8.2 15 9 2 169.0 3.6 15 12 9 24.6 11.1 15 2 17 20.6 10.3 15 5 21 18.8 9.5 15 9 3 122.7 3.7 15 12 10 64.4 9.5 15 2 18 124.2 9.1 15 5 22 70.6 17.4 15 9 4 93.6 5.6 15 12 11 31.2 13.6 15 2 19 95.8 11.8 15 5 23 80.8 17.3 15 9 5 311.4 4.9 15 12 12 140.0 8.2 15 2 20 52.6 15.2 15 6 0 69.5 6.0 15 9 6 188.3 4.3 15 12 13 20.4 10.3 15 2 21 24.5 12.4 15 6 1 37.1 11.4 15 9 7 144.0 5.1 15 12 14 327.6 19.7 15 2 22 141.8 11.4 15 6 2 136.3 3.9 15 9 8 51.6 13.2 15 12 15 64.6 12.0 15 3 0 80.3 11.5 15 6 3 27.9 11.7 15 9 9 101.3 8.1 15 12 16 70.4 12.8 15 3 1 144.4 4.3 15 6 4 186.3 3.9 15 9 10 72.3 9.2 15 12 17 36.4 16.4 15 3 2 75.3 8.0 15 6 5 157.9 4.6 15 9 11 240.5 4.5 15 12 18 152.7 7.0 15 3 3 219.4 4.8 15 6 6 29.6 12.8 15 9 12 183.4 4.7 15 12 19 29.6 13.5 15 3 4 163.6 3.8 15 6 7 19.6 9.6 15 9 13 155.5 5.0 15 12 20 45.9 16.8 15 3 5 110.7 6.0 15 6 9 163.7 5.2 15 9 14 30.6 12.6 15 12 21 54.6 16.3 15 3 6 201.6 4.9 15 6 10 40.7 14.4 15 9 15 432.6 13.5 15 13 0 65.0 8.0 15 3 7 169.3 4.1 15 6 11 28.6 12.2 15 9 16 61.1 15.2 15 13 1 15.8 7.9 15 3 8 116.8 5.1 15 6 12 100.9 7.5 15 9 17 93.9 8.0 15 13 2 78.0 5.3 15 3 9 55.0 10.9 15 6 13 84.6 10.4 15 9 18 20.1 10.1 15 13 3 111.1 8.6 15 3 10 104.4 6.5 15 6 14 25.2 12.2 15 9 19 69.2 16.1 15 13 4 82.6 5.1 15 3 11 155.5 5.1 15 6 15 23.0 11.5 15 9 20 22.2 11.0 15 13 5 41.7 11.6 15 3 12 78.7 8.3 15 6 16 449.6 15.1 15 9 21 87.6 11.5 15 13 6 92.9 6.1 15 3 13 213.4 5.2 15 6 17 130.0 6.9 15 9 22 28.2 13.9 15 13 7 85.2 6.4 15 3 14 86.7 8.2 15 6 18 176.0 5.7 15 10 0 126.3 3.8 15 13 8 141.1 5.1 15 3 15 195.3 5.5 15 6 19 176.3 9.1 15 10 1 118.9 5.8 15 13 9 138.9 5.8 15 3 16 97.5 20.2 15 6 20 169.9 6.4 15 10 2 251.2 4.7 15 13 10 24.0 11.4 15 3 18 83.8 13.5 15 6 21 48.7 17.0 15 10 3 41.2 10.8 15 13 11 76.5 9.0 15 3 19 98.4 12.9 15 6 22 56.1 14.9 15 10 4 71.3 8.3 15 13 13 285.1 12.8 15 3 20 44.1 16.7 15 7 0 173.6 3.6 15 10 5 29.7 12.6 15 13 14 25.4 12.0 15 3 21 30.5 15.0 15 7 1 58.2 11.6 15 10 6 176.8 5.1 15 13 15 185.2 5.7 15 3 22 117.8 8.4 15 7 2 166.4 4.3 15 10 7 56.2 11.4 15 13 16 39.6 13.9 15 3 23 67.8 15.5 15 7 3 81.5 6.3 15 10 8 189.0 5.6 15 13 17 64.3 13.7 15 4 0 57.8 15.9 15 7 4 129.2 3.9 15 10 9 156.2 4.9 15 13 18 159.2 7.8 15 4 1 196.8 3.9 15 7 5 126.8 6.2 15 10 10 177.7 5.3 15 13 19 87.6 9.5 15 4 2 245.8 4.9 15 7 6 157.6 7.7 15 10 11 126.1 7.5 15 13 21 177.1 9.8 15 4 3 160.7 6.0 15 7 7 71.0 10.0 15 10 12 157.6 4.8 15 14 0 71.4 6.0 15 4 4 53.2 7.7 15 7 8 67.2 9.1 15 10 13 125.3 6.3 15 14 1 84.9 7.4 15 4 5 131.9 8.3 15 7 9 75.8 7.9 15 10 14 80.8 12.9 15 14 2 205.8 3.8 15 4 6 67.9 9.1 15 7 10 95.1 8.9 15 10 15 128.1 19.6 15 14 3 82.9 5.8 15 4 7 134.9 5.9 15 7 11 167.1 5.1 15 10 16 58.0 15.8 15 14 4 30.0 13.2 15 4 8 213.2 4.2 15 7 12 119.2 5.7 15 10 17 110.9 8.7 15 14 5 102.3 6.4 15 4 9 147.1 5.1 15 7 13 178.9 5.7 15 10 18 100.3 8.2 15 14 6 148.2 6.3 15 4 10 34.5 15.7 15 7 14 77.5 11.1 15 10 19 79.3 12.9 15 14 7 83.4 7.7 15 4 11 49.8 12.7 15 7 16 76.6 22.7 15 10 20 49.4 18.9 15 14 8 19.9 10.0 15 4 12 142.1 4.9 15 7 17 112.7 6.7 15 10 21 32.4 14.5 15 14 9 93.7 7.3 15 4 13 101.7 8.5 15 7 18 39.0 15.3 15 11 0 41.7 10.2 15 14 10 61.6 11.6 15 4 14 135.1 5.6 15 7 19 55.3 16.6 15 11 1 16.2 8.1 15 14 11 48.4 13.6 15 4 15 89.7 9.7 15 7 20 131.4 8.2 15 11 2 74.7 5.8 15 14 13 123.1 34.3 15 4 16 400.8 53.1 15 7 21 42.6 16.3 15 11 3 47.6 11.0 15 14 14 21.1 10.3 15 -4 18 26.7 12.8 15 7 22 123.5 8.4 15 11 4 131.0 6.8 15 14 15 40.2 15.4 15 4 19 53.2 16.7 15 8 0 44.1 9.9 15 11 5 94.7 7.2 15 14 16 125.8 6.3 15 4 20 141.7 7.4 15 8 1 191.6 4.4 15 11 6 72.3 10.5 15 14 17 184.0 5.8 15 4 22 64.7 16.7 15 8 2 139.5 5.4 15 11 7 140.0 5.5 15 14 18 63.8 17.3 15 4 23 23.0 11.6 15 8 3 100.5 4.9 15 11 8 97.5 6.2 15 14 19 28.4 13.4 15 5 0 154.9 4.6 15 8 4 61.9 7.6 15 11 9 105.3 5.6 15 15 0 30.3 13.2 15 5 1 207.3 4.2 15 8 5 136.1 5.8 15 11 10 109.8 6.6 15 15 1 19.7 9.4 15 5 2 86.5 6.3 15 8 6 150.3 5.8 15 11 11 38.1 13.3 15 15 2 130.4 4.9 15 5 3 73.4 8.4 15 8 7 19.8 9.6 15 11 12 66.6 10.1 15 15 3 87.4 5.9 15 5 4 44.1 10.8 15 8 8 135.4 4.5 15 11 13 169.9 4.8 15 15 4 127.2 3.9 15 5 5 177.8 4.3 15 8 9 56.2 13.1 15 11 14 259.9 15.4 15 15 5 127.8 5.5 15 5 6 257.4 5.3 15 8 10 102.5 7.8 15 11 16 68.9 10.6 15 15 6 35.2 12.8 15 5 7 192.9 4.2 15 8 11 33.5 13.5 15 11 18 132.4 7.8 15 15 7 122.4 6.6 15 5 8 169.2 5.2 15 8 12 21.5 10.4 15 11 19 143.7 7.7 15 15 8 37.0 16.0 15 5 9 109.6 7.6 15 8 13 151.4 5.5 15 11 20 118.5 11.4 15 15 9 177.3 5.4 15 5 10 148.6 5.9 15 8 14 97.8 9.2 15 11 21 56.8 16.4 15 15 10 130.7 6.2 15 5 11 103.7 6.5 15 8 15 188.5 14.3 15 12 0 87.3 6.9 15 15 11 20.8 10.1 15 5 12 161.1 4.9 15 8 16 40.4 15.5 15 12 1 94.8 5.8 15 15 12 382.7 15.2 15 5 13 61.9 14.9 15 8 17 17.3 8.7 15 12 2 73.7 5.6 15 15 13 19.6 9.8 15 5 14 50.4 14.4 15 8 18 81.2 10.2 15 12 3 119.2 9.3 15 15 14 131.4 6.3 15 5 15 91.7 9.4 15 8 19 102.8 10.5 15 12 4 124.1 4.0 15 15 15 105.4 7.7 WO 99/10379 PCT/GB98/02542 -155 15 15 16 125.5 6.6 15 19 10 91.7 6.8 15 24 0 80.5 5.0 15 30 4 99.0 7.1 15 15 17 95.1 9.0 15 19 11 136.6 5.2 15 24 1 115.0 5.9 16 0 0 73.9 7.7 15 15 18 87.6 12.0 15 19 12 35.0 13.1 15 24 2 28.0 11.3 16 0 1 30.2 16.7 15 15 19 48.1 18.7 15 19 13 145.4 5.7 15 24 3 23.9 9.9 16 0 2 36.0 22.8 15 15 20 33.3 15.7 15 19 14 42.7 14.7 15 24 4 132.9 5.1 16 0 3 201.4 5.5 15 16 0 92.6 8.6 15 19 15 171.2 6.1 15 24 5 183.5 4.8 16 0 4 10.3 7.7 15 16 1 178.3 4.6 15 19 16 144.2 6.6 15 24 6 83.9 6.1 16 0 5 93.8 12.9 15 16 2 188.1 3.9 15 19 17 33.6 13.9 15 24 7 49.4 13.4 16 0 6 85.7 20.5 15 16 3 118.5 5.8 15 19 18 27.4 13.1 15 24 8 27.5 12.4 16 0 7 76.5 18.7 15 16 4 77.2 12.2 15 20 0 99.6 4.8 15 24 9 104.0 7.0 16 0 8 96.9 20.7 15 16 5 160.1 4.2 15 20 1 128.3 5.1 15 24 10 25.1 12.1 16 0 9 103.9 8.2 15 16 6 87.2 8.1 15 20 2 185.8 6.7 15 24 11 121.4 5.6 16 0 10 214.7 6.1 15 16 7 253.4 4.4 15 20 3 223.2 5.2 15 24 12 102.3 8.5 16 0 11 70.8 19.5 15 16 8 38.5 12.6 15 20 4 40.5 11.0 15 24 13 77.0 10.4 16 0 12 19.6 13.8 15 16 9 104.1 5.4 15 20 5 160.9 4.1 15 24 14 36.7 15.4 16 0 13 57.6 22.0 15 16 11 279.8 10.0 15 20 6 149.5 19.6 15 25 0 48.5 13.8 16 0 14 532.9 18.9 15 16 12 17.1 8.7 15 20 7 271.1 14.0 15 25 1 144.3 4.1 16 0 15 24.2 17.5 15 16 13 80.5 8.4 15 20 8 19.6 9.9 15 25 2 74.8 9.3 16 0 17 55.8 22.9 15 16 14 70.7 11.2 15 20 10 80.6 7.7 15 25 4 142.4 4.1 16 0 18 78.5 25.4 15 16 15 89.8 9.4 15 20 11 132.3 6.0 15 25 5 71.0 9.2 16 0 19 27.5 19.2 15 16 16 81.2 13.0 15 20 12 63.9 14.0 15 25 6 90.3 5.0 16 0 20 139.9 17.5 15 16 17 122.7 8.1 15 20 13 81.2 9.0 15 25 7 146.1 7.5 16 0 21 34.6 23.8 15 16 18 83.0 11.0 15 20 14 108.4 8.4 15 25 8 118.3 5.7 16 1 0 53.4 7.3 15 16 19 100.4 12.6 15 20 15 23.4 11.5 15 25 9 47.4 15.2 16 1 1 36.4 14.1 15 17 0 157.7 3.9 15 20 16 55.7 16.4 15 25 10 150.5 5.3 16 1 2 144.1 7.9 15 17 1 87.8 9.4 15 20 17 69.5 12.6 15 25 11 109.6 6.6 16 1 3 73.3 8.0 15 17 2 115.2 3.8 15 21 0 33.7 11.2 15 25 12 89.1 8.1 16 1 4 106.9 4.5 15 17 3 121.8 4.1 15 21 2 14.9 7.4 15 25 13 60.8 12.2 16 1 5 115.2 8.9 15 17 4 155.5 4.4 15 21 3 20.3 10.0 15 26 0 101.3 5.6 16 1 6 19.8 10.1 15 17 5 126.0 4.7 15 21 4 106.7 15.8 15 26 1 107.1 9.0 16 1 7 109.0 7.3 15 17 6 149.4 6.7 15 21 5 268.9 10.8 15 26 2 101.7 5.3 16 1 8 26.0 11.9 15 17 7 24.7 10.9 15 21 6 98.8 6.0 15 26 3 72.8 6.1 16 1 9 129.4 5.1 15 17 8 32.7 13.0 15 21 7 94.3 8.9 15 26 4 41.5 12.3 16 1 10 87.0 8.1 15 17 10 348.2 12.3 15 21 8 72.5 8.1 15 26 5 68.4 7.1 16 1 11 78.6 9.8 15 17 11 34.3 16.2 15 21 9 163.5 5.4 15 26 6 194.1 4.3 16 1 12 132.8 5.5 15 17 12 31.1 13.4 15 21 10 39.1 14.5 15 26 7 44.2 17.2 16 1 13 27.0 12.6 15 17 13 51.5 17.0 15 21 11 68.1 13.1 15 26 8 153.6 8.6 16 1 14 533.2 16.2 15 17 14 104.2 7.0 15 21 12 85.5 8.3 15 26 9 102.9 9.2 16 1 16 89.9 9.5 15 17 15 62.6 11.8 15 21 13 159.4 5.8 15 26 10 55.1 12.5 16 1 17 152.3 7.0 15 17 16 86.8 9.9 15 21 14 147.3 9.2 15 26 11 113.4 7.4 16 1 18 155.1 9.4 15 17 17 99.8 12.9 15 21 15 150.5 6.8 15 27 0 108.1 8.2 16 1 19 79.9 19.8 15 17 18 104.1 14.8 15 21 16 175.5 6.3 15 27 1 130.2 4.2 16 1 20 98.2 11.6 15 17 19 43.4 17.1 15 22 0 136.6 15.2 15 27 2 114.1 6.2 16 1 21 71.2 18.9 15 18 0 133.7 5.4 15 22 1 246.1 10.6 15 27 3 45.7 12.3 16 2 0 140.6 3.6 15 18 1 107.8 4.3 15 22 2 296.6 12.6 15 27 4 156.0 5.6 16 2 1 269.8 5.2 15 18 2 93.6 8.6 15 22 3 325.0 9.9 15 27 5 89.5 10.5 16 2 2 146.6 7.5 15 18 3 61.4 6.9 15 22 5 80.5 10.6 15 27 6 18.9 9.1 16 2 3 18.8 9.3 15 18 4 66.3 6.3 15 22 6 38.8 12.2 15 27 8 36.1 11.1 16 2 4 152.5 3.9 15 18 5 44.2 11.5 15 22 7 124.6 5.4 15 27 9 159.1 5.5 16 2 5 148.0 6.3 15 18 6 54.6 12.0 15 22 8 93.4 9.7 15 27 10 15.8 8.0 16 2 6 36.1 15.0 15 18 7 70.4 8.1 15 22 9 122.0 5.6 15 28 0 44.0 13.2 16 2 7 102.2 6.9 15 18 8 143.5 5.5 15 22 10 30.6 12.7 15 28 1 108.7 4.4 16 2 8 140.5 5.5 15 18 9 404.2 19.0 15 22 11 48.8 13.1 15 28 2 68.7 7.0 16 2 9 152.7 4.5 15 18 10 42.6 17.6 15 22 12 101.6 7.5 15 28 3 88.3 6.7 16 2 10 28.5 12.2 15 18 11 21.7 10.5 15 22 13 89.1 8.2 15 28 4 138.1 4.3 16 2 11 27.4 12.5 15 18 12 62.3 12.5 15 22 14 49.6 13.4 15 28 5 82.4 5.9 16 2 12 53.6 13.1 15 18 13 67.3 12.6 15 22 15 29.0 13.5 15 28 6 83.6 5.4 16 2 13 54.2 15.8 15 18 14 195.1 5.4 15 23 0 15.7 7.9 15 28 7 79.3 14.7 16 2 14 467.4 10.9 15 18 15 155.5 7.2 15 23 2 103.7 5.1 15 28 8 22.3 11.0 16 2 16 94.7 9.5 15 18 16 166.1 5.9 15 23 3 36.0 13.2 15 28 9 22.9 11.2 16 2 17 169.9 7.0 15 18 17 33.1 14.0 15 23 4 130.1 5.1 15 29 0 137.8 3.8 16 2 19 150.9 10.9 15 18 18 85.9 13.5 15 23 5 164.5 4.5 15 29 1 32.9 14.5 16 2 20 75.5 15.3 15 19 0 100.6 6.1 15 23 6 99.8 5.5 15 29 2 138.2 5.9 16 2 21 78.0 18.4 15 19 1 171.4 4.5 15 23 7 76.4 6.3 15 29 3 85.5 6.2 16 3 0 59.6 7.1 15 19 2 65.2 6.0 15 23 8 100.3 8.2 15 29 4 65.7 9.4 16 3 1 160.5 4.3 15 19 3 105.8 9.4 15 23 9 69.5 9.8 15 29 5 24.7 11.0 16 3 2 53.7 8.6 15 19 4 145.2 6.4 15 23 10 102.7 7.6 15 29 6 24.1 10.9 16 3 3 73.3 7.0 15 19 5 70.1 8.5 15 23 11 38.2 14.5 15 29 7 18.1 9.0 16 3 4 119.4 8.5 15 19 6 219.1 4.5 15 23 12 89.0 8.5 15 30 0 43.5 15.7 16 3 5 97.5 9.0 15 19 7 23.0 11.6 15 23 13 129.1 5.1 15 30 1 91.9 4.8 16 3 6 122.2 8.4 15 19 8 341.6 10.7 15 23 14 54.7 13.8 15 30 2 21.8 10.3 16 3 7 102.8 7.2 15 19 9 156.5 5.4 15 23 15 26.1 12.7 15 30 3 53.0 11.6 16 3 8 91.8 7.2 WO 99/10379 PCT/GB98/02542 -156 16 3 9 204.8 4.4 16 6 17 147.7 6.9 16 10 5 30.4 13.7 16 14 1 98.4 5.6 16 3 10 99.8 6.2 16 6 18 104.7 10.0 16 10 6 106.7 6.9 16 14 2 126.4 4.0 16 3 11 104.6 8.9 16 6 19 22.0 10.9 16 10 7 164.7 4.3 16 14 3 69.7 7.7 16 3 12 131.2 5.3 16 6 20 30.2 14.4 16 10 8 66.0 8.8 16 14 4 35.4 12.6 16 3 13 27.4 13.2 16 6 21 124.6 8.4 16 10 9 64.1 12.1 16 14 5 140.7 5.7 16 3 14 472.1 13.6 16 7 0 48.1 9.8 16 10 10 48.4 14.4 16 14 6 190.5 6.6 16 3 15 27.1 13.1 16 7 1 183.5 4.6 16 10 12 482.0 20.2 16 14 7 84.9 8.1 16 3 16 115.7 8.5 16 7 2 135.3 8.0 16 10 13 35.0 15.6 16 14 9 267.3 30.7 16 3 17 36.2 16.3 16 7 3 150.1 4.9 16 10 14 19.1 9.5 16 14 10 42.8 19.2 16 3 18 92.8 13.9 16 7 4 15.8 7.8 16 10 15 62.6 13.5 16 14 11 18.4 9.3 16 3 19 58.5 20.2 16 7 5 85.0 7.1 16 10 16 51.2 18.2 16 14 12 23.5 11.2 16 320 146.0 6.9 16 7 6 99.8 9.1 16 10 17 120.4 8.1 16 14 13 45.3 17.3 16 3 21 34.1 16.0 16 7 7 105.8 6.4 16 10 18 29.0 13.6 16 14 14 92.7 10.0 16 4 0 78.2 5.3 16 7 8 78.3 8.4 16 10 19 78.5 14.2 16 14 15 207.4 6.3 16 4 1 30.8 11.8 16 7 9 94.9 7.4 16 10 20 45.2 16.4 16 14 16 125.9 8.3 16 4 2 25.4 11.0 16 7 10 148.3 5.1 16 11 0 88.6 8.0 16 14 17 45.3 15.2 16 4 3 36.8 13.3 16 7 11 179.7 5.8 16 11 1 93.7 5.7 16 14 18 70.6 15.3 16 4 4 212.2 4.8 16 7 12 203.6 5.1 16 11 2 102.2 4.7 16 15 0 253.8 5.1 16 4 5 124.3 8.1 16 7 13 492.4 12.0 16 11 3 124.3 8.7 16 15 1 78.9 8.1 16 4 6 87.2 10.0 16 7 14 27.3 13.6 16 11 4 151.7 3.8 16 15 2 30.4 12.2 16 4 7 94.4 8.2 16 7 15 157.0 6.0 16 11 5 84.0 5.7 16 15 3 127.0 4.6 16 4 8 31.5 13.0 16 7 16 87.2 9.1 16 11 6 102.2 6.4 16 15 4 125.5 4.0 16 4 9 90.4 6.6 16 7 17 89.9 11.2 16 11 7 82.6 7.7 16 15 5 106.8 6.4 16 4 10 27.6 12.3 16 7 18 108.2 10.9 16 11 8 71.9 9.8 16 15 6 137.2 5.1 16 4 11 61.9 13.0 16 7 19 225.6 6.2 16 11 9 32.6 14.0 16 15 7 71.0 11.4 16 4 12 149.0 5.0 16 7 20 147.1 8.5 16 11 10 38.4 15.0 16 15 8 198.0 17.7 16 4 13 28.2 13.9 16 8 0 107.6 6.1 16 11 11 208.1 13.5 16 15 10 142.8 8.8 16 4 14 286.0 15.6 16 8 1 43.7 11.7 16 11 13 32.4 14.1 16 15 11 83.4 7.5 16 4 15 128.1 8.8 16 8 2 195.0 4.0 16 11 14 123.0 6.4 16 15 12 79.0 8.2 16 4 16 115.8 8.6 16 8 3 16.0 7.9 16 11 15 101.3 8.7 16 15 13 131.9 6.7 16 4 17 98.0 12.9 16 8 4 126.6 4.0 16 11 16 122.0 8.5 16 15 14 35.7 14.4 16 4 18 25.8 12.6 16 8 5 175.1 5.8 16 11 17 141.6 8.7 16 15 15 97.0 10.9 16 4 19 73.5 22.7 16 8 6 137.0 6.9 16 11 18 64.5 14.3 16 15 16 44.4 16.7 16 4 20 78.6 14.2 16 8 7 138.2 5.2 16 11 19 48.5 17.6 16 15 17 81.9 11.5 16 4 21 66.6 18.5 16 8 8 130.8 5.1 16 12 0 146.5 4.3 16 15 18 47.2 17.5 16 5 0 223.5 3.9 16 8 9 121.6 5.5 16 12 1 189.8 4.0 16 16 0 112.0 4.2 16 5 1 119.3 5.1 16 8 10 173.6 6.0 16 12 2 226.6 6.2 16 16 1 122.7 4.6 16 5 2 117.8 4.9 16 8 11 168.3 5.4 16 12 3 153.2 5.3 16 16 2 39.0 15.2 16 5 3 167.2 5.1 16 8 12 37.3 15.7 16 12 4 46.0 10.0 16 16 3 151.3 7.2 16 5 4 66.9 7.3 16 8 13 264.4 17.3 16 12 5 204.0 4.8 16 16 4 39.6 16.5 16 5 5 35.7 14.8 16 8 14 24.1 11.6 16 12 6 46.7 15.0 16 16 5 155.6 4.0 16 5 6 39.3 14.9 16 8 15 111.4 8.7 16 12 7 150.9 5.6 16 16 7 244.0 15.9 16 5 7 179.5 5.4 16 8 16 87.3 9.4 16 12 8 67.7 13.5 16 16 9 50.1 17.7 16 5 8 20.9 10.3 16 8 17 92.9 11.5 16 12 9 45.5 14.2 16 16 10 124.9 7.0 16 5 9 101.4 7.1 16 8 18 56.1 18.7 16 12 10 20.2 10.1 16 16 11 154.7 5.0 16 5 10 95.2 7.7 16 8 19 90.1 11.3 16 12 11 279.1 10.9 16 16 12 17.3 8.8 16 5 11 123.1 6.4 16 8 20 90.7 11.0 16 12 13 55.9 15.3 16 16 13 136.0 7.1 16 5 12 35.5 13.7 16 9 0 77.6 6.9 16 12 14 25.5 12.2 16 16 14 255.7 6.7 16 5 14 115.1 33.1 16 9 1 103.1 6.3 16 12 15 69.0 12.6 16 16 15 47.8 15.9 16 5 15 100.2 11.1 16 9 2 64.0 7.4 16 12 16 137.8 7.4 16 16 16 48.5 15.9 16 5 16 94.2 12.0 16 9 3 154.4 4.2 16 12 17 30.9 14.7 16 16 17 136.0 7.3 16 -5 17 106.4 9.3 16 9 4 29.7 12.6 16 12 18 28.9 13.7 16 17 0 92.5 6.2 16 5 18 225.7 7.1 16 9 5 73.2 9.8 16 12 19 25.3 12.2 16 17 1 169.6 3.9 16 5 19 21.9 11.0 16 9 6 189.2 4.8 16 13 0 80.0 7.2 16 17 2 64.1 9.5 16 5 20 71.9 15.0 16 9 7 44.6 14.8 16 13 1 37.4 12.8 16 17 3 213.1 4.1 16 5 21 49.9 19.1 16 9 8 71.9 8.5 16 13 2 106.7 6.3 16 17 4 18.8 9.4 16 6 0 122.0 4.9 16 9 9 103.3 6.5 16 13 3 145.9 4.2 16 17 5 41.7 12.5 16 6 1 79.3 6.1 16 9 10 163.1 5.1 16 13 4 47.2 13.8 16 17 6 365.1 12.5 16 6 2 95.2 4.7 16 9 11 67.8 10.9 16 13 5 34.8 12.5 16 17 7 67.1 19.0 16 6 3 178.6 4.6 16 9 12 313.0 10.3 16 13 7 66.0 10.9 16 17 8 113.4 11.6 16 6 4 79.2 5.7 16 9 14 135.6 5.4 16 13 8 33.9 14.2 16 17 9 86.5 8.7 16 6 5 183.7 6.5 16 9 15 101.1 12.3 16 13 9 32.3 13.4 16 17 10 127.9 7.0 16 6 6 34.3 14.3 16 9 16 138.8 7.5 16 13 10 408.6 14.8 16 17 11 69.7 16.4 16 6 7 103.8 7.1 16 9 17 89.9 9.1 16 13 12 32.9 13.6 16 17 12 51.1 16.2 16 6 8 51.5 13.3 16 9 18 25.2 12.4 16 13 13 69.2 11.5 16 17 13 58.2 15.7 16 6 9 103.5 10.5 16 9 19 45.5 18.0 16 13 14 53.8 16.6 16 17 14 132.0 7.5 16 6 10 124.0 6.2 16 9 20 30.6 14.1 16 13 15 61.9 16.1 16 17 15 30.5 14.1 16 6 11 218.5 4.9 16 10 0 120.5 5.5 16 13 16 73.0 13.9 16 17 16 98.0 10.4 16 6 12 31.4 13.5 16 10 1 122.3 5.6 16 13 17 171.0 7.3 16 17 17 60.2 16.5 16 6 13 290.3 16.0 16 10 2 100.6 6.2 16 13 18 36.3 16.0 16 18 0 17.6 8.7 16 6 15 40.9 14.8 16 10 3 149.9 5.2 16 13 19 87.4 13.0 16 18 3 25.1 11.4 16 6 16 60.8 14.9 16 10 4 87.9 12.5 16 14 0 27.9 11.8 16 18 4 274.3 12.4 WO 99/10379 PCT/GB98/02542 -157 16 18 5 355.2 20.7 16 22 13 92.5 8.5 17 0 17 165.7 11.0 17 4 16 179.6 7.3 16 18 6 73.9 18.4 16 23 0 87.4 7.1 17 0 18 107.8 24.7 17 4 17 176.8 6.7 16 18 7 17.6 8.8 16 23 I 83.5 12.7 17 0 19 35.7 22.9 17 4 18 151.5 7.5 16 18 8 93.2 9.4 16 23 2 72.6 9.5 17 1 0 67.5 15.3 17 4 19 72.5 14.9 16 18 9 59.6 11.3 16 23 3 173.5 5.0 17 1 1 50.0 16.2 17 5 0 49.4 11.6 16 18 10 183.8 5.0 16 23 4 90.4 6.8 17 1 2 70.2 7.8 17 5 1 166.0 4.1 16 18 11 93.4 8.3 16 23 5 154.8 4.8 17 1 3 32.4 13.0 17 5 2 33.9 13.2 16 18 12 57.0 13.0 16 23 6 37.0 15.1 17 1 4 72.3 8.0 17 5 3 42.0 12.7 16 18 13 123.6 10.6 16 23 7 35.7 13.4 17 1 5 63.8 15.8 17 5 4 231.4 7.2 16 18 14 183.2 6.4 16 23 8 95.1 7.8 17 1 6 153.5 9.6 17 5 5 83.8 9.5 16 18 15 30.7 14.1 16 23 9 103.4 9.8 17 1 7 44.0 14.8 17 5 6 69.0 9.8 16 18 16 106.8 7.9 16 23 10 186.7 5.5 17 1 8 53.6 13.0 17 5 7 105.4 8.0 16 19 0 103.2 13.8 16 23 11 72.5 13.2 17 1 9 144.2 8.6 17 5 8 87.0 10.0 16 19 1 221.2 10.0 16 23 12 79.4 11.9 17 1 10 30.0 14.9 17 5 9 117.4 8.7 16 19 2 252.1 13.1 16 24 0 140.8 4.0 17 1 11 316.3 10.6 17 5 10 237.2 16.9 16 19 3 155.0 21.4 16 24 1 17.5 8.8 17 1 13 32.4 13.6 17 5 12 87.8 9.2 16 19 4 21.9 11.1 16 24 2 121.8 6.3 17 1 14 120.8 9.6 17 5 13 20.5 10.3 16 19 5 67.3 8.5 16 24 3 62.6 17.2 17 1 15 80.6 15.1 17 5 14 132.9 7.4 16 19 6 65.3 8.8 16 24 4 80.2 11.2 17 1 16 112.7 9.7 17 5 16 124.2 8.9 16 19 7 76.1 10.3 16 24 5 86.7 7.7 17 1 18 102.3 14.5 17 5 17 81.7 10.9 16 19 8 77.5 8.9 16 24 6 27.6 12.3 17 2 0 170.5 6.2 17 5 18 37.2 15.5 16 19 9 25.3 11.5 16 24 7 118.9 5.0 17 2 1 73.9 11.5 17 5 19 33.9 15.7 16 19 10 108.3 9.3 16 24 8 79.5 11.2 17 2 2 203.9 5.1 17 6 0 94.4 6.0 16 19 11 30.5 13.2 16 24 9 68.6 14.3 17 2 3 139.1 4.5 17 6 2 25.5 11.4 16 19 12 71.9 10.7 16 24 10 55.4 14.3 17 2 4 172.2 4.3 17 6 3 102.6 5.9 16 19 13 53.0 14.8 16 24 11 19.8 10.0 17 2 5 152.4 6.6 17 6 4 118.6 4.9 16 19 14 150.1 6.4 16 25 0 130.6 6.2 17 2 6 156.1 6.0 17 6 5 56.1 10.1 16 19 15 74.5 13.3 16 25 1 211.5 6.7 17 2 7 106.4 7.0 17 6 6 87.1 8.4 16 20 0 133.6 7.6 16 25 2 80.8 9.0 17 2 8 122.8 6.1 17 6 7 127.9 8.1 16 20 1 88.3 6.4 16 25 3 51.7 9.6 17 2 11 334.7 8.3 17 6 8 145.7 5.5 16 20 2 83.6 8.2 16 25 4 130.2 4.9 17 2 12 26.3 13.0 17 6 10 298.6 10.7 16 20 3 14.6 7.3 16 25 5 37.5 12.9 17 2 13 71.1 10.9 17 6 12 76.7 11.2 16 20 4 19.6 9.8 16 25 6 68.4 6.8 17 2 14 67.5 16.0 17 6 13 35.5 14.8 16 20 5 54.3 9.0 16 25 7 31.1 11.9 17 2 15 52.2 19.8 17 6 14 72.8 14.6 16 20 6 109.5 11.2 16 25 8 21.3 10.1 17 2 16 141.3 7.4 17 6 15 186.0 7.5 16 20 7 66.8 14.5 16 25 9 47.3 17.2 17 2 17 136.4 8.1 17 6 16 101.9 9.7 16 20 8 37.9 15.2 16 25 10 34.5 16.8 17 2 18 32.6 15.0 17 6 17 185.2 6.8 16 20 9 144.4 6.3 16 26 1 29.7 11.4 17 2 19 138.6 8.3 17 6 18 93.1 10.8 16 20 10 146.6 8.2 16 26 2 102.5 5.9 17 3 0 107.5 6.5 17 6 19 141.7 7.5 16 20 11 179.2 9.0 16 26 3 65.5 8.4 17 3 1 26.5 12.1 17 7 0 143.4 3.9 16 20 12 110.7 9.2 16 26 4 124.8 6.5 17 3 2 122.1 4.8 17 7 1 55.0 11.7 16 20 13 81.0 9.1 16 26 5 25.1 11.6 17 3 3 140.3 5.2 17 7 2 26.7 11.0 16 20 14 24.6 11.7 16 26 6 71.0 8.3 17 3 4 139.1 6.0 17 7 3 142.8 4.3 16 20 15 23.6 11.6 16 26 7 47.5 17.5 17 3 5 127.7 5.9 17 7 4 47.3 10.8 16 21 0 120.7 6.1 16 26 8 60.0 17.3 17 3 6 21.2 10.5 17 7 5 99.6 7.0 16 21 1 118.9 9.6 16 27 0 69.5 7.2 17 3 8 117.2 6.2 17 7 6 84.9 10.0 16 21 2 103.9 5.4 16 27 1 100.2 8.3 17 3 9 31.6 14.7 17 7 7 42.2 14.9 16 21 3 71.5 6.7 16 27 2 107.4 10.8 17 3 11 301.4 10.9 17 7 8 29.0 12.8 16 21 4 56.9 8.2 16 27 3 23.9 10.8 17 3 12 21.1 10.5 17 7 10 297.7 14.1 16 21 5 64.0 7.4 16 27 4 43.1 12.7 17 3 13 100.3 10.3 17 7 11 27.0 12.8 16 21 6 51.8 9.4 16 27 5 73.9 6.6 17 3 14 61.6 17.4 17 7 12 47.3 15.1 16 -21 7 119.5 7.6 16 27 6 24.2 11.4 17 3 15 62.6 16.2 17 7 13 135.8 7.1 16 21 8 15.3 7.8 16 28 0 31.6 14.5 17 3 16 151.7 8.4 17 7 14 93.8 10.9 16 21 9 92.4 7.8 16 28 1 57.5 7.8 17 3 17 36.1 14.7 17 7 15 84.3 15.9 16 21 10 111.6 7.8 16 28 2 113.8 5.5 17 3 18 39.3 16.5 17 7 17 26.4 12.9 16 21 11 66.8 9.5 16 28 3 41.9 15.0 17 3 19 154.7 8.3 17 7 18 125.7 10.9 16 21 12 25.2 11.9 16 28 4 116.1 17.3 17 4 0 86.2 6.4 17 8 0 134.0 4.5 16 21 13 99.9 10.7 17 0 0 125.7 13.0 17 4 1 38.5 11.9 17 8 1 120.3 8.3 16 21 14 39.8 16.5 17 0 2 106.8 7.8 17 4 2 166.1 4.8 17 8 2 46.6 9.9 16 22 0 144.1 4.2 17 0 3 128.5 7.6 17 4 3 32.0 13.4 17 8 3 101.8 5.0 16 22 1 17.9 8.7 17 0 4 21.2 14.4 17 4 4 45.7 17.5 17 8 4 74.4 8.0 16 22 2 56.6 8.6 17 0 5 25.2 16.7 17 4 5 72.7 9.7 17 8 5 158.2 4.4 16 22 3 66.6 10.6 17 0 6 251.8 8.1 17 4 6 140.2 8.2 17 8 6 120.1 8.8 16 22 4 153.0 5.6 17 0 7 20.9 14.7 17 4 7 105.3 7.8 17 8 7 71.2 11.4 16 22 5 72.4 8.7 17 0 8 165.2 7.9 17 4 8 148.9 5.5 17 8 8 20.5 10.2 16 22 6 106.5 5.3 17 0 9 96.3 16.5 17 4 9 73.7 17.2 17 8 9 318.3 11.6 16 22 7 33.9 13.9 17 0 10 42.8 26.2 17 4 10 89.6 19.4 17 8 11 75.0 10.9 16 22 8 150.4 6.0 17 0 11 488.1 14.6 17 4 11 252.8 13.9 17 8 12 105.1 7.9 16 22 9 151.5 6.8 17 0 13 15.5 11.5 17 4 12 28.5 13.0 17 8 13 107.6 7.4 16 22 10 74.8 9.9 17 0 14 48.3 25.5 17 4 13 22.4 11.1 17 8 14 109.7 8.3 16 22 11 84.6 8.2 17 0 15 107.2 18.7 17 4 14 35.3 16.6 17 8 15 164.0 8.1 16 22 12 17.5 8.9 17 0 16 183.8 10.3 17 4 15 41.0 16.5 17 8 16 67.1 17.7 WO 99/10379 PCT/GB98/02542 -158 17 8 17 108.1 8.2 17 13 0 147.2 6.1 17 17 14 180.9 6.3 17 24 2 92.9 8.7 17 8 18 58.5 17.2 17 13 1 216.5 4.6 17 18 0 135.3 5.2 17 24 3 100.3 12.9 17 9 0 114.9 4.8 17 13 2 142.8 4.5 17 18 1 65.4 9.3 17 24 4 50.1 19.2 17 9 1 148.5 4.2 17 13 3 159.4 4.7 17 18 2 65.1 7.4 17 24 5 54.7 13.0 17 9 2 25.2 11.4 17 13 5 291.4 14.7 17 18 3 150.2 4.5 17 24 6 84.1 11.8 17 9 3 170.4 5.1 17 13 6 367.7 15.6 17 18 4 135.4 4.6 17 24 7 65.4 9.8 17 9 4 168.3 8.0 17 13 8 53.1 15.0 17 18 5 142.2 5.7 17 25 0 80.4 9.2 17 9 5 104.5 6.7 17 13 9 119.6 8.7 17 18 6 37.3 14.1 17 25 1 16.3 8.1 17 9 6 58.3 15.0 17 13 10 131.3 6.9 17 18 7 122.8 7.2 17 25 2 65.2 8.0 17 9 7 166.0 5.9 17 13 11 44.1 15.4 17 18 9 124.0 7.1 17 25 3 69.4 9.7 17 9 9 435.4 15.3 17 13 12 199.9 6.8 17 18 10 79.9 10.7 17 25 4 35.0 12.8 17 9 10 21.8 10.9 17 13 13 136.5 7.0 17 18 11 48.9 19.4 17 25 5 53.3 16.9 17 9 11 115.3 9.0 17 13 14 33.3 15.0 17 18 12 89.3 12.0 17 26 0 33.0 14.2 17 9 12 106.1 8.8 17 13 15 157.9 7.0 17 18 13 61.2 14.7 17 26 1 31.4 14.2 17 9 13 43.0 16.5 17 13 16 102.6 10.3 17 19 0 94.4 6.2 17 26 2 161.7 36.4 17 9 14 61.1 15.1 17 14 0 75.3 7.2 17 19 1 37.0 14.6 18 0 0 17.0 11.8 17 9 15 244.9 8.8 17 14 1 58.8 9.2 17 19 2 25.2 11.2 18 0 1 101.1 15.7 17 9 16 80.0 17.4 17 14 3 67.4 16.7 17 19 3 66.8 19.3 18 0 2 182.7 12.9 17 9 17 26.0 12.5 17 14 4 383.3 14.7 17 19 4 109.8 11.7 18 0 3 129.0 26.1 17 9 18 42.6 16.1 17 14 5 201.0 11.5 17 19 5 55.0 18.9 18 0 4 29.3 21.1 17 10 0 78.7 7.2 17 14 7 88.2 7.7 17 19 6 112.4 7.2 18 0 6 312.8 30.8 17 10 1 157.3 4.9 17 14 8 57.7 14.6 17 19 7 115.4 11.8 18 0 7 361.4 10.3 17 10 2 125.8 9.7 17 14 9 76.3 11.7 17 19 8 198.7 8.2 18 0 9 71.4 19.1 17 10 3 237.7 6.9 17 14 10 39.3 14.5 17 19 9 22.9 11.2 18 0 10 15.9 11.9 17 10 4 107.2 6.5 17 14 11 57.0 17.4 17 19 10 116.8 10.4 18 0 11 45.4 23.5 17 10 5 142.5 9.4 17 14 12 105.5 10.3 17 19 11 34.9 15.2 18 0 12 171.7 12.3 17 10 6 29.2 14.1 17 14 13 178.0 8.1 17 19 12 113.0 7.6 18 0 13 125.6 13.4 17 10 7 22.9 11.2 17 14 14 29.0 12.9 17 19 13 33.3 13.9 18 0 14 52.1 25.4 17 10 8 414.7 14.3 17 14 15 74.7 14.1 17 20 0 138.6 9.1 18 0 15 21.7 15.4 17 10 10 45.6 15.4 17 14 16 93.6 10.3 17 20 1 59.3 13.0 18 0 16 73.6 24.2 17 10 11 34.7 15.4 17 15 0 45.8 19.3 17 20 2 171.1 5.3 18 1 0 141.8 4.3 17 10 12 57.5 17.0 17 15 1 178.7 12.7 17 20 3 31.6 13.9 18 1 1 164.8 6.6 17 10 13 76.3 17.0 17 15 2 449.6 12.9 17 20 4 99.7 6.2 18 1 2 45.8 15.1 17 10 14 153.4 6.2 17 15 3 217.7 15.2 17 20 5 32.4 13.4 18 1 3 99.6 21.9 17 10 16 23.9 11.9 17 15 4 84.4 11.4 17 20 6 135.8 5.5 18 1 4 36.8 17.8 17 10 17 83.5 12.4 17 15 5 15.2 7.6 17 20 7 156.6 7.6 18 1 6 262.8 18.6 17 10 18 103.4 14.5 17 15 6 97.3 7.3 17 20 8 24.6 11.4 18 1 7 360.2 10.9 17 11 0 26.5 12.2 17 15 7 89.4 9.9 17 20 9 24.6 12.1 18 1 9 67.5 12.1 17 11 1 44.6 12.8 17 15 8 85.4 9.6 17 20 10 70.1 10.6 18 1 10 165.6 6.5 17 11 2 125.3 6.7 17 15 9 146.7 6.1 17 20 11 39.5 15.8 18 1 11 79.0 12.4 17 11 3 99.2 6.9 17 15 10 54.6 14.8 17 20 12 74.0 16.0 18 1 12 158.1 6.9 17 11 4 62.7 8.2 17 15 11 152.2 6.3 17 21 0 138.0 5.5 18 1 13 73.8 14.8 17 11 5 15.8 7.9 17 15 12 93.4 11.4 17 21 1 69.6 7.8 18 1 14 39.4 16.0 17 11 6 36.1 13.7 17 15 13 181.5 7.3 17 21 2 235.3 4.9 18 1 15 76.1 11.8 17 11 7 252.4 14.9 17 15 14 87.2 9.8 17 21 3 71.1 7.7 18 1 16 119.6 8.7 17 11 8 175.2 11.5 17 15 15 134.6 8.0 17 21 4 93.6 6.6 18 1 17 40.9 16.1 17 11 9 36.3 14.2 17 16 0 266.0 16.7 17 21 5 184.0 8.4 18 2 0 70.8 7.1 17 11 10 38.1 15.7 17 16 1 115.2 8.7 17 21 6 77.9 10.4 18 2 1 145.3 4.5 17 11 11 140.2 6.1 17 16 2 24.2 12.1 17 21 7 64.3 8.4 18 2 2 202.8 7.6 17 11 12 44.1 15.1 17 16 5 166.6 7.6 17 21 8 177.0 9.0 18 2 3 87.1 24.9 17 11 13 32.0 15.1 17 16 6 215.6 4.6 17 21 9 37.4 15.4 18 2 4 45.1 15.9 17 41 14 147.8 7.1 17 16 7 56.3 15.7 17 21 10 100.7 8.0 18 2 5 112.6 12.7 17 11 15 80.5 10.7 17 16 8 38.3 14.0 17 22 0 174.4 7.5 18 2 6 371.4 25.6 17 11 16 40.6 17.1 17 16 9 72.1 11.9 17 22 1 191.5 7.3 18 2 7 387.0 17.0 17 11 17 89.1 12.8 17 16 10 20.0 10.0 17 22 2 178.6 7.6 18 2 9 60.2 15.3 17 12 0 155.6 7.7 17 16 11 122.7 7.4 17 22 3 167.5 8.5 18 2 10 106.1 10.2 17 12 1 21.8 10.4 17 16 13 65.3 13.5 17 22 4 60.7 19.6 18 2 11 83.6 11.5 17 12 2 99.4 5.8 17 16 14 29.6 13.5 17 22 5 83.1 14.9 18 2 12 20.1 10.1 17 12 3 66.1 8.0 17 16 15 21.9 10.8 17 22 6 30.3 13.3 18 2 13 131.4 8.5 17 12 4 20.0 9.9 17 17 1 84.0 6.6 17 22 7 95.7 11.5 18 2 14 50.4 16.9 17 12 5 114.7 6.6 17 17 2 87.3 8.2 17 22 8 90.5 14.3 18 2 15 28.6 13.3 17 12 6 116.1 9.6 17 17 3 100.7 8.5 17 22 9 50.8 14.9 18 2 16 86.6 12.3 17 12 7 272.4 12.9 17 17 4 21.2 10.4 17 22 10 26.7 13.5 18 2 17 22.8 11.4 17 12 9 38.5 16.2 17 17 5 67.9 8.3 17 23 0 113.6 5.1 18 3 0 136.7 6.2 17 12 10 32.6 13.8 17 17 6 137.0 4.6 17 23 2 113.2 6.2 18 3 1 121.7 6.8 17 12 11 42.6 14.4 17 17 7 95.1 6.3 17 23 3 80.1 7.0 18 3 2 91.1 9.6 17 12 12 26.4 12.4 17 17 8 98.3 7.6 17 23 4 97.0 5.4 18 3 3 70.9 25.4 17 12 13 169.2 18.8 17 17 9 23.4 11.4 17 23 5 59.8 8.3 18 3 4 100.0 12.8 17 12 14 34.0 15.9 17 17 10 98.0 11.3 17 23 6 49.4 12.0 18 3 5 20.2 10.2 17 12 15 111.4 9.9 17 17 11 17.7 8.9 17 23 7 178.2 5.8 18 3 6 409.5 15.9 17 12 16 44.5 18.2 17 17 12 72.5 14.7 17 23 8 29.8 13.9 18 3 7 285.7 15.1 17 12 17 61.5 19.0 17 17 13 77.2 11.5 17 24 1 83.3 13.2 18 3 9 38.5 15.1 WO 99/10379 PCT/GB98/02542 -159 18 3 10 87.2 11.6 18 7 15 30.1 13.8 18 12 11 34.5 15.7 18 18 1 120.7 7.5 18 3 11 120.0 7.5 18 7 16 39.3 16.3 18 12 12 23.3 11.5 18 18 2 106.7 7.6 18 3 12 75.2 12.0 18 8 0 15.2 7.7 18 12 13 87.7 10.0 18 18 3 113.7 9.1 18 3 13 111.3 9.7 18 8 1 133.1 7.9 18 12 14 58.0 17.2 18 18 4 106.1 5.7 18 3 14 25.8 12.7 18 8 2 67.5 9.4 18 13 0 50.8 13.9 18 18 5 84.4 7.8 18 3 15 28.7 13.4 18 8 3 266.6 20.1 18 13 1 102.0 8.2 18 18 6 51.1 11.6 18 3 16 80.0 15.4 18 8 4 360.8 13.3 18 13 2 28.5 12.3 18 18 7 23.8 10.7 18 3 17 32.5 14.7 18 8 5 19.2 9.7 18 13 3 112.2 6.7 18 18 8 101.8 9.4 18 4 0 51.6 11.9 18 8 6 32.1 13.9 18 13 4 133.4 7.2 18 18 9 64.0 15.2 18 4 1 105.5 8.5 18 8 7 86.5 10.4 18 13 5 106.1 6.3 18 18 10 26.5 13.2 18 4 2 143.1 16.5 18 8 8 94.0 9.1 18 13 6 31.2 13.9 18 19 0 90.0 9.3 18 4 3 39.8 18.9 18 8 9 135.3 6.4 18 13 7 54.2 13.0 18 19 1 78.6 9.0 18 4 4 88.2 9.3 18 8 10 122.0 8.1 18 13 8 71.0 13.1 18 19 2 124.6 7.1 18 4 5 133.5 6.1 18 8 11 28.5 13.3 18 13 9 70.5 16.8 18 19 3 63.0 23.5 18 4 6 398.3 12.3 18 8 12 235.4 5.3 18 13 10 41.0 17.5 18 19 4 247.2 6.1 18 4 7 247.5 22.8 18 8 13 83.8 13.2 18 13 11 36.4 15.5 18 19 5 29.2 14.4 18 4 8 64.1 13.5 18 8 14 62.2 12.4 18 13 12 26.8 13.4 18 19 6 100.7 15.3 18 4 9 136.2 6.4 18 8 15 112.3 10.6 18 13 14 21.3 10.6 18 19 7 49.8 12.8 18 4 10 51.1 18.9 18 8 16 34.8 15.5 18 14 0 159.2 6.6 18 19 8 27.9 12.4 18 4 11 111.7 8.5 18 9 1 95.2 12.5 18 14 1 72.6 13.8 18 19 9 67.5 13.3 18 4 12 106.3 11.1 18 9 2 332.6 14.7 18 14 2 80.8 9.2 18 20 0 29.8 13.0 18 4 13 161.1 7.0 18 9 3 448.4 14.4 18 14 3 130.0 6.7 18 20 1 47.8 15.3 18 4 14 38.0 16.7 18 9 4 62.2 24.4 18 14 4 66.2 12.1 18 20 2 151.0 8.4 18 4 15 28.5 13.4 18 9 5 20.9 10.6 18 14 5 59.9 9.3 18 20 3 116.4 7.5 18 4 16 97.2 9.8 18 9 6 55.4 13.4 18 14 6 85.1 8.6 18 20 4 158.9 6.6 18 4 17 96.9 11.5 18 9 7 26.8 12.7 18 14 7 148.6 6.5 18 20 5 123.6 10.5 18 5 0 133.5 7.6 18 9 8 100.6 12.1 18 14 8 138.4 6.9 18 20 6 31.2 12.1 18 5 1 63.0 18.1 18 9 9 94.5 9.7 18 14 9 80.6 12.4 18 20 7 82.9 9.2 18 5 2 155.7 17.3 18 9 10 89.3 13.1 18 14 10 40.4 17.5 18 20 8 25.5 12.8 18 5 3 37.1 14.8 18 9 11 33.1 14.3 18 14 11 46.9 15.4 18 21 0 75.5 11.9 18 5 4 50.9 14.2 18 9 12 249.2 8.4 18 14 12 35.6 16.2 18 21 1 166.9 5.5 18 5 5 115.9 12.2 18 9 13 92.9 12.8 18 14 13 79.1 14.1 18 21 2 54.4 14.5 18 5 6 156.0 7.5 18 9 14 34.3 13.9 18 15 0 59.9 12.4 18 21 3 68.6 11.1 18 5 7 45.0 18.7 18 9 15 48.8 15.3 18 15 1 89.4 8.5 18 21 4 42.8 12.5 18 5 8 29.5 13.2 18 10 0 311.7 11.0 18 15 2 134.9 5.9 18 21 5 18.7 9.2 18 5 9 78.2 9.9 18 10 1 349.2 10.0 18 15 3 34.8 16.0 18 21 6 74.5 8.1 18 5 10 198.2 8.9 18 10 2 263.7 9.6 18 15 4 73.3 8.1 18 21 7 48.8 13.9 18 5 11 77.0 16.2 18 10 3 155.0 9.8 18 15 5 88.9 7.5 18 22 0 124.9 5.3 18 5 12 28.3 14.0 18 10 5 134.3 6.6 18 15 6 83.3 11.1 18 22 1 78.1 8.1 18 5 13 126.0 8.1 18 10 6 63.1 8.5 18 15 7 156.4 13.7 18 22 2 136.2 6.4 18 5 14 98.0 11.7 18 10 8 192.0 6.1 18 15 8 136.3 8.3 18 22 3 20.0 10.0 18 5 16 86.3 12.8 18 10 9 71.4 14.6 18 15 9 114.5 11.8 18 22 4 98.9 14.5 18 6 0 248.3 5.6 18 10 10 135.9 9.0 18 15 10 29.1 13.8 18 22 5 44.4 18.9 18 6 1 26.3 12.7 18 10 11 148.3 7.4 18 15 11 112.3 9.2 18 23 0 25.9 12.0 18 6 2 149.3 4.6 18 10 12 149.8 7.5 18 15 12 52.0 18.5 18 23 1 109.9 6.1 18 6 3 173.5 5.4 18 10 13 57.4 15.7 18 15 13 124.8 9.8 18 23 3 79.2 17.3 18 6 4 124.5 9.3 18 10 14 147.3 11.9 18 16 0 131.6 4.5 19 0 0 14.9 11.0 18 6 5 242.4 12.2 18 11 0 254.6 11.3 18 16 1 22.0 10.1 19 0 1 12.0 9.0 18 6 6 174.3 5.2 18 11 1 99.5 9.5 18 16 2 167.2 8.3 19 0 2 24.4 15.3 18 6 7 91.1 13.4 18 11 2 22.6 10.9 18 16 3 151.8 5.8 19 0 3 76.5 35.1 18 6 8 144.0 5.7 18 11 3 113.5 5.6 18 16 4 87.4 9.2 19 0 4 86.1 35.0 18 .6 9 56.1 15.6 18 11 4 177.2 4.6 18 16 5 137.4 7.9 19 0 5 129.9 7.7 18 6 10 159.1 6.7 18 11 5 18.2 9.1 18 16 6 29.9 13.0 19 0 6 203.9 7.3 18 6 11 115.9 10.6 18 11 6 108.0 5.9 18 16 7 421.3 59.6 19 0 7 22.9 16.7 18 6 12 101.3 9.8 18 11 7 111.6 8.3 18 16 8 51.1 16.1 19 0 8 67.5 21.5 18 6 13 119.8 9.2 18 11 8 137.3 8.6 18 16 9 136.4 8.0 19 0 9 108.2 18.4 18 6 14 28.7 13.5 18 11 9 91.7 12.6 18 16 10 136.3 8.3 19 0 10 117.8 15.1 18 6 15 35.7 16.3 18 11 10 60.7 19.7 18 16 11 83.9 13.4 19 0 11 194.2 15.8 18 6 16 111.5 9.7 18 11 11 361.6 17.9 18 16 12 26.7 12.7 19 0 12 63.2 21.8 18 7 0 64.5 9.3 18 11 12 69.6 14.5 18 17 0 121.0 6.8 19 0 13 125.8 12.2 18 7 1 99.2 6.5 18 11 14 30.6 13.5 18 17 1 54.2 12.7 19 0 14 85.1 25.1 18 7 3 36.2 13.9 18 11 15 25.8 12.7 18 17 2 106.1 12.8 19 1 0 101.1 7.4 18 7 4 185.2 9.4 18 12 1 114.8 5.6 18 17 3 54.4 16.5 19 1 1 77.7 8.2 18 7 5 308.5 15.8 18 12 2 144.6 5.9 18 17 4 95.0 10.6 19 1 2 109.6 5.7 18 7 7 34.7 14.7 18 12 3 20.9 10.2 18 17 5 132.6 5.8 19 1 3 33.2 16.4 18 7 8 51.7 13.9 18 12 4 45.4 14.4 18 17 6 186.8 10.8 19 1 4 86.5 20.4 18 7 9 30.9 14.0 18 12 5 139.6 5.6 18 17 7 17.1 8.6 19 1 5 147.0 11.6 18 7 10 98.7 10.8 18 12 6 29.0 12.1 18 17 8 127.4 11.4 19 1 6 50.9 16.2 18 7 11 83.5 12.3 18 12 7 91.4 9.8 18 17 9 26.7 12.5 19 1 7 55.2 19.2 18 7 12 29.0 13.9 18 12 8 91.9 8.4 18 17 10 18.0 9.2 19 1 8 115.5 7.9 18 7 13 186.1 7.1 18 12 9 108.0 12.3 18 17 11 144.7 8.6 19 1 9 122.0 11.5 18 7 14 87.0 10.7 18 12 10 193.5 9.6 18 18 0 153.9 5.9 19 1 10 139.6 7.8 WO 99/10379 PCT/GB98/02542 -160 19 1 11 52.2 20.6 19 6 9 170.9 6.7 19 12 3 149.8 7.3 20 0 1 40.1 26.9 19 1 12 51.2 16.0 19 6 10 130.5 12.1 19 12 4 95.8 7.6 20 0 2 66.5 14.7 19 1 13 111.2 10.7 19 6 11 97.4 10.7 19 12 5 182.6 6.1 20 0 3 113.4 9.4 19 1 14 38.8 16.5 19 6 12 47.0 20.1 19 12 6 67.1 12.2 20 0 4 162.5 8.5 19 2 0 18.9 9.4 19 6 13 39.3 16.5 19 12 7 28.0 12.8 20 0 5 237.2 14.2 19 2 1 43.1 15.5 19 7 0 112.2 6.3 19 12 8 106.1 10.5 20 0 6 153.5 20.4 19 2 2 80.4 9.7 19 7 1 91.4 7.4 19 12 9 96.9 9.9 20 0 7 65.9 22.0 19 2 3 83.7 12.3 19 7 2 55.3 19.9 19 12 10 26.6 13.3 20 0 8 99.7 16.8 19 2 4 135.3 14.0 19 7 3 117.8 8.8 19 12 11 20.8 10.4 20 0 9 88.6 22.8 19 2 5 59.9 9.5 19 7 4 129.3 7.7 19 13 0 17.0 8.6 20 0 10 42.5 26.1 19 2 6 105.6 6.5 19 7 5 111.3 13.3 19 13 1 90.2 9.7 20 0 11 29.3 19.1 19 2 7 72.1 19.4 19 7 6 55.5 20.8 19 13 2 24.7 11.9 20 1 0 82.4 21.4 19 2 8 98.7 9.0 19 7 7 59.0 14.5 19 13 3 126.1 7.4 20 1 1 67.8 14.0 19 2 9 68.4 16.2 19 7 8 27.5 13.3 19 13 4 232.0 8.7 20 1 2 43.0 13.6 19 2 10 131.4 8.8 19 7 9 137.2 9.6 19 13 5 29.6 13.5 20 1 3 25.2 12.0 19 2 11 30.1 15.1 19 7 10 26.2 13.0 19 13 6 30.1 12.6 20 1 4 155.6 6.2 19 2 12 28.4 13.8 19 7 11 72.7 16.8 19 13 7 71.6 17.8 20 1 5 57.8 14.8 19 2 13 70.1 15.9 19 7 12 28.2 13.7 19 13 8 42.7 15.8 20 1 6 88.2 12.2 19 3 0 34.8 13.0 19 7 13 25.4 12.6 19 13 9 33.3 14.9 20 1 7 24.0 12.0 19 3 1 51.1 15.8 19 8 0 134.6 8.8 19 13 10 127.2 14.4 20 1 8 63.4 14.1 19 3 2 30.8 13.4 19 8 1 35.3 14.8 19 14 0 42.2 14.0 20 1 9 50.3 18.5 19 3 3 129.9 8.3 19 8 2 74.4 13.4 19 14 1 190.0 5.0 20 1 10 33.6 15.7 19 3 4 33.4 13.2 19 8 3 35.8 14.3 19 14 2 115.7 6.1 20 1 11 39.5 17.3 19 3 5 74.3 7.7 19 8 4 42.3 13.8 19 14 3 167.1 8.4 20 2 0 48.4 21.0 19 3 6 40.0 13.7 19 8 5 63.9 12.2 19 14 4 158.4 9.0 20 2 1 54.3 17.9 19 3 7 241.7 9.3 19 8 6 40.1 14.0 19 14 5 142.8 7.2 20 2 2 21.0 10.1 19 3 8 164.3 6.1 19 8 7 21.2 10.5 19 14 6 131.2 13.0 20 2 3 191.7 6.8 19 3 9 136.9 8.2 19 8 8 165.1 7.6 19 14 7 69.0 11.3 20 2 4 119.8 7.7 19 3 10 214.1 10.5 19 8 9 178.9 7.2 19 14 8 67.3 13.9 20 2 5 74.1 14.2 19 3 11 45.5 18.5 19 8 10 68.7 15.0 19 14 9 29.1 13.7 20 2 6 32.9 15.4 19 3 12 88.3 11.4 19 8 11 44.1 18.7 19 14 10 31.7 14.8 20 2 7 50.0 17.7 19 3 13 128.8 8.9 19 8 12 34.3 15.7 19 15 0 153.8 9.6 20 2 8 37.1 16.4 19 3 14 44.5 17.0 19 8 13 21.5 10.9 19 15 1 202.0 7.9 20 2 9 62.3 18.7 19 4 0 69.3 8.1 19 9 0 47.6 16.9 19 15 2 152.2 8.2 20 2 10 70.2 18.1 19 4 1 150.4 4.8 19 9 1 35.6 13.8 19 15 3 29.5 13.3 20 2 11 54.3 21.7 19 4 2 153.0 9.0 19 9 2 83.8 8.5 19 15 4 154.6 5.2 20 3 0 37.4 18.4 19 4 3 119.8 9.1 19 9 3 116.1 6.4 19 15 5 135.3 12.0 20 3 1 142.6 8.5 19 4 4 32.9 14.6 19 9 4 49.9 14.5 19 15 6 147.5 9.4 20 3 2 88.3 7.9 19 4 5 17.0 8.5 19 9 5 118.3 12.5 19 15 7 163.7 10.8 20 3 3 143.8 8.7 19 4 6 103.3 6.8 19 9 7 75.8 11.6 19 15 8 31.4 13.5 20 3 4 224.7 8.1 19 4 7 133.9 12.7 19 9 8 110.8 11.2 19 15 9 22.5 11.3 20 3 5 137.8 11.9 19 4 8 86.6 10.3 19 9 9 75.0 10.9 19 16 0 39.9 15.5 20 3 6 249.5 10.5 19 4 9 142.0 7.8 19 9 10 115.4 11.5 19 16 1 18.6 9.4 20 3 7 51.4 17.5 19 4 10 93.1 12.6 19 9 11 97.9 11.6 19 16 2 80.9 10.9 20 3 8 152.4 8.4 19 4 11 23.3 11.6 19 9 12 115.4 8.7 19 16 3 38.1 14.5 20 3 9 40.5 16.9 19 4 12 47.7 16.6 19 10 0 39.3 14.0 19 16 4 23.9 11.6 20 3 10 53.8 22.0 19 4 13 115.2 8.1 19 10 1 180.4 4.8 19 16 5 61.8 13.2 20 4 0 111.7 10.1 19 4 14 23.3 11.6 19 10 2 93.4 6.4 19 16 6 142.1 10.8 20 4 1 71.7 11.4 19 5 0 152.1 5.9 19 10 3 44.5 13.9 19 16 7 77.2 9.5 20 4 2 69.9 9.1 19 5 1 61.2 9.5 19 10 4 47.1 14.5 19 16 8 57.3 15.2 20 4 3 188.7 5.6 19 5 2 168.8 5.8 19 10 5 81.6 27.1 19 17 0 97.2 9.1 20 4 4 71.6 15.1 19 .5 3 77.1 14.8 19 10 6 113.5 8.5 19 17 1 30.0 12.6 20 4 5 67.1 12.0 19 5 4 94.4 8.4 19 10 7 275.8 8.3 19 17 2 80.2 9.7 20 4 6 36.5 17.6 19 5 5 134.8 5.7 19 10 8 74.5 21.5 19 17 3 256.9 6.1 20 4 7 61.4 21.6 19 5 6 100.2 7.9 19 10 10 147.5 7.5 19 17 4 161.2 11.2 20 4 8 83.4 12.5 19 5 7 105.5 14.6 19 10 11 45.1 16.8 19 17 5 21.2 10.3 20 4 9 56.7 18.2 19 5 8 122.4 10.6 19 10 12 121.6 9.4 19 17 6 76.2 8.4 20 5 0 48.0 16.2 19 5 9 168.2 8.4 19 11 0 67.0 13.0 19 17 7 101.5 20.3 20 5 1 142.7 11.4 19 5 10 171.1 7.6 19 11 1 46.6 13.0 19 18 0 157.5 9.8 20 5 2 162.2 10.5 19 5 11 35.7 17.3 19 11 2 46.1 16.5 19 18 1 158.2 11.1 20 5 3 224.0 11.0 19 5 12 64.5 15.2 19 11 3 158.6 6.3 19 18 2 38.3 14.5 20 5 4 114.0 14.0 19 5 13 53.5 17.1 19 11 4 47.4 13.2 19 18 3 110.4 9.0 20 5 5 80.8 13.4 19 5 14 146.3 8.4 19 11 5 35.8 13.8 19 18 4 39.7 14.5 20 5 6 159.8 10.9 19 6 0 101.9 7.9 19 11 6 86.8 9.3 19 18 5 37.0 13.2 20 5 7 93.2 9.9 19 6 1 37.4 13.7 19 11 7 155.3 11.4 19 18 6 70.3 15.7 20 5 8 56.8 16.7 19 6 2 65.9 13.6 19 11 8 127.4 9.3 19 19 0 99.8 8.0 20 5 9 55.9 16.5 19 6 3 122.5 14.7 19 11 10 30.9 14.1 19 19 2 19.9 9.9 20 5 10 28.6 13.9 19 6 4 74.8 9.3 19 11 11 31.1 15.1 19 19 3 137.3 6.5 20 6 0 93.0 8.4 19 6 5 32.9 13.8 19 11 12 28.2 14.2 19 19 4 43.5 16.3 20 6 1 85.5 9.5 19 6 6 111.9 8.4 19 12 0 19.5 9.8 19 20 0 18.0 9.1 20 6 2 73.1 10.7 19 6 7 61.7 13.8 19 12 1 28.4 14.2 19 20 1 24.1 12.1 20 6 3 146.9 7.9 19 6 8 78.9 13.0 19 12 2 67.6 13.6 20 0 0 47.9 30.0 20 6 4 48.7 13.4 WO 99/10379 PCT/GB98/02542 -161 20 6 5 25.4 12.8 20 15 3 36.6 15.4 20 6 6 38.3 14.4 20 16 0 50.7 17.6 20 6 7 38.7 15.6 21 0 0 135.7 7.8 20 6 8 65.7 20.8 21 0 1 133.3 17.4 20 6 9 36.6 15.1 21 0 2 74.5 17.5 20 7 0 144.2 5.8 21 0 3 158.3 24.1 20 7 1 188.1 7.5 21 0 4 148.2 11.7 20 7 2 137.2 12.6 21 0 5 70.0 18.3 20 7 3 151.4 12.0 21 1 0 125.7 5.7 20 7 4 134.4 6.1 21 1 1 113.3 8.1 20 7 5 38.6 15.9 21 1 2 57.5 14.1 20 7 6 27.1 12.3 21 1 3 60.6 13.5 20 7 7 70.6 10.4 21 1 4 64.3 14.4 20 7 8 128.5 17.6 21 1 5 28.2 12.5 20 8 0 105.4 6.7 21 2 0 130.6 11.0 20 8 1 69.1 15.2 21 2 1 85.8 10.6 20 8 2 185.4 16.6 21 2 2 25.1 11.9 20 8 3 20.6 10.1 21 2 3 19.4 9.7 20 8 5 99.3 15.6 21 2 4 21.3 10.6 20 8 6 17.3 8.8 21 2 5 54.6 15.2 20 8 7 73.8 11.2 21 3 0 96.9 10.5 20 8 8 24.7 12.2 21 3 1 43.9 15.3 20 8 9 47.3 17.5 21 3 2 64.4 15.3 20 9 0 113.0 7.0 21 3 3 44.5 18.3 20 9 1 62.0 16.4 21 3 5 37.9 16.0 20 9 2 82.2 10.4 21 4 0 65.6 13.6 20 9 3 68.4 10.4 21 4 1 80.6 10.6 20 9 4 23.9 11.4 21 4 2 76.7 10.9 20 9 5 101.2 9.4 21 4 3 53.7 18.1 20 9 6 32.7 14.2 21 4 4 36.5 17.2 20 9 7 48.0 19.6 21 4 5 42.7 17.3 20 9 8 39.3 14.4 21 5 0 36.6 14.9 20 10 0 68.1 12.6 21 5 1 66.1 13.5 20 10 1 83.0 17.8 21 5 3 41.1 16.5 20 10 2 53.0 16.4 21 5 5 38.5 16.0 20 10 3 92.6 15.0 21 6 0 41.7 16.8 20 10 4 118.9 9.0 21 6 1 22.9 11.3 20 10 5 51.3 15.6 21 6 2 32.1 13.3 20 10 6 67.3 11.1 21 6 3 76.9 17.5 20 10 7 41.9 16.5 21 6 4 158.1 18.5 20 10 8 80.6 10.5 21 7 1 86.5 17.7 20 11 0 210.9 5.3 21 7 2 61.9 14.1 20 11 1 56.8 15.2 21 7 3 64.2 17.4 20 11 2 42.1 16.1 21 7 4 44.0 17.8 20 11 3 80.6 12.1 21 8 0 31.0 13.3 20 11 4 77.6 10.2 21 8 1 50.7 12.6 20 11 5 97.2 14.2 21 8 2 58.5 14.5 20 11 6 23.4 11.0 21 9 0 112.8 6.9 20 11 7 22.6 11.2 21 9 1 23.5 11.2 20 12 0 71.3 10.7 20 12 1 41.4 14.6 20 42 2 25.2 11.7 20 12 3 171.2 10.7 20 12 4 77.8 11.9 20 12 5 131.0 12.7 20 12 6 76.2 10.1 20 12 7 37.1 16.5 20 13 0 108.0 8.8 20 13 1 222.7 5.3 20 13 2 107.3 7.5 20 13 3 103.8 7.9 20 13 4 165.7 11.2 20 13 5 165.4 13.6 20 13 6 27.9 13.9 20 14 0 146.0 12.4 20 14 1 114.1 16.2 20 14 2 34.9 13.2 20 14 3 26.4 12.2 20 14 4 29.2 14.2 20 15 0 31.1 13.5 20 15 1 27.1 12.7 20 15 2 24.2 11.8 WO 99/10379 PCT/GB98/02542 -162 Table 2a. CRYSTI 42.196 83.729 67.237 90.00 93.30 90.00 P21 SCALE1 0.023699 0.000000 0.001366 0.00000 SCALE2 0.000000 0.011943 0.000000 0.00000 SCALE3 0.000000 0.000000 0.014897 0.00000 ATOM 1 CB ILEL 3 31.902 -1.191 8.768 1.0022.21 ATOM 2 CG2 ILE L 3 30.875 -2.276 8.525 1.00 27.45 ATOM 3 CG1 ILEL 3 31.406 0.116 8.180 1.0024.21 ATOM 4 CD ILE L 3 32.355 1.270 8.270 1.0025.48 ATOM 5 C ILE L 3 30.888 -0.418 10.820 1.00 21.44 ATOM 6 0 ILE L 3 29.871 -1.082 10.995 1.00 20.56 ATOM 9 NILE L 3 32.253 -2.429 10.853 1.00 20.99 ATOM 11 CA ILEL 3 32.105 -1.078 10.243 1.00 21.17 ATOM 12 N VALL 4 30.990 0.881 11.105 1.00 20.05 ATOM 14 CA VAL L 4 29.896 1.599 11.741 1.00 20.43 ATOM 15 CB VAL L 4 30.381 2.218 13.048 1.00 17.54 ATOM 16 CG1 VALL 4 29.197 2.800 13.811 1.00 19.60 ATOM 17 CG2 VAL L 4 31.096 1.156 13.881 1.00 17.28 ATOM 18 C VALL 4 29.326 2.701 10.850 1.00 20.60 ATOM 19 0 VALL 4 30.054 3.606 10.449 1.0020.97 ATOM 20 N VALL 5 28.011 2.621 10.592 1.0020.30 ATOM 22 CA VAL L 5 27.315 3.571 9.733 1.00 17.97 ATOM 23 CB VAL L 5 26.358 2.798 8.809 1.00 17.56 ATOM 24 CG1 VALL 5 25.506 3.735 7.957 1.00 16.02 ATOM 25 CG2 VAL L 5 27.175 1.852 7.930 1.00 17.98 ATOM 26 C VALL 5 26.543 4.542 10.611 1.00 18.99 ATOM 27 0 VALL 5 25.657 4.124 11.342 1.00 18.18 ATOM 28 N THRL 6 26.884 5.823 10.548 1.00 17.10 ATOM 30 CA THRL 6 26.268 6.830 11.456 1.00 16.73 ATOM 31 CB THRL 6 27.382 7.654 12.134 1.00 15.12 ATOM 32 OG1 THRL 6 28.147 6.801 12.972 1.00 17.77 ATOM 34 CG2THRL 6 26.834 8.782 12.972 1.00 20.38 ATOM 35 C THRL 6 25.301 7.783 10.753 1.00 15.26 ATOM 36 O THRL 6 25.593 8.273 9.658 1.00 14.60 ATOM 37 N GLNL 7 24.149 8.058 11.416 1.00 14.21 ATOM 39 CA GLN L 7 23.142 8.992 10.920 1.00 9.76 ATOM 40 CB GLN L 7 21.885 8.241 10.518 1.00 8.55 ATOM 41 CG GLN L 7 22.057 7.199 9.423 1.00 3.66 ATOM 42 CD GLN L 7 20.729 6.615 9.060 1.00 4.16 ATOM 43 OE1 GLN L 7 20.464 5.462 9.328 1.00 10.06 ATOM 44 NE2 GLN L 7 19.846 7.417 8.477 1.00 2.55 ATOM 47 C GLN L 7 22.792 9.979 12.041 1.00 12.95 ATOM 48 O GLN L 7 23.187 9.761 13.186 1.00 12.95 ATOM 49 N GLU L 8 22.069 11.059 11.708 1.00 14.59 ATOM 51 CA GLUL 8 21.637 12.040 12.711 1.00 9.44 ATOM 52 CB GLUL 8 21.113 13.314 12.073 1.00 3.83 ATOM 53 CG GLU L 8 22.174 14.132 11.394 1.00 8.12 ATOM 54 CD GLU L 8 22.252 13.870 9.886 1.00 12.60 ATOM 55 OEI GLU L 8 21.617 12.890 9.417 1.00 8.76 ATOM 56 OE2 GLU L 8 22.962 14.647 9.168 1.00 12.58 ATOM 57 C GLUL 8 20.521 11.441 13.515 1.00 9.97 ATOM 58 O GLU L 8 19.632 10.819 12.949 1.00 10.41 ATOM 59 N SERL 9 20.492 11.676 14.825 1.00 11.56 ATOM 61 CA SERL 9 19.452 11.049 15.611 1.00 8.58 ATOM 62 CB SERL 9 19.753 11.118 17.124 1.00 14.23 ATOM 63 OG SERL 9 20.332 12.351 17.498 1.0021.30 ATOM 65 C SERL 9 18.098 11.562 15.319 1.00 7.24 ATOM 66 O SERL 9 17.176 10.785 15.235 1.00 6.90 ATOM 67 N ALAL 10 17.926 12.851 15.161 1.00 6.82 ATOM 69 CA ALA L 10 16.586 13.348 14.866 1.00 6.68 ATOM 70 CB ALA L 10 15.775 13.505 16.147 1.00 9.20 ATOM 71 C ALA L 10 16.689 14.682 14.231 1.00 6.99 ATOM 72 O ALAL 10 17.644 15.388 14.502 1.00 8.81 ATOM 73 N LEUL 11 15.696 15.040 13.440 1.00 7.46 ATOM 75 CA LEUL 11 15.657 16.351 12.799 1.00 6.63 ATOM 76 CB LEUL 11 16.162 16.267 11.333 1.00 10.52 ATOM 77 CG LEUL 11 17.513 15.589 11.044 1.00 10.17 ATOM 78 CD1 LEUL 11 17.767 15.551 9.544 1.00 8.53 ATOM 79 CD2 LEU L 11 18.631 16.325 11.724 1.00 7.59 ATOM 80 C LEU L 11 14.205 16.806 12.766 1.00 5.60 ATOM 81 O LEUL 11 13.331 15.972 12.663 1.00 7.61 WO 99/10379 PCT/GB98/02542 -163 ATOM 82 N THRL 12 13.961 18.126 12.816 1.00 4.15 ATOM 84 CA THRL 12 12.600 18.697 12.814 1.00 6.68 ATOM 85 CB THRL 12 12.357 19.494 14.139 1.00 10.20 ATOM 86 OGI THRL 12 12.556 18.628 15.276 1.00 10.18 ATOM 88 CG2 THRL 12 10.955 20.089 14.157 1.00 4.50 ATOM 89 C THRL 12 12.442 19.705 11.661 1.00 9.42 ATOM 90 O THRL 12 13.343 20.532 11.404 1.00 11.76 ATOM 91 N THRL 13 11.321 19.713 11.016 1.00 12.34 ATOM 93 CA THR L 13 11.160 20.652 9.956 1.00 13.42 ATOM 94 CB THRL 13 11.709 20.016 8.626 1.00 15.26 ATOM 95 OGI THRL 13 12.053 21.031 7.672 1.00 19.73 ATOM 97 CG2THRL 13 10.695 19.089 8.020 1.00 15.31 ATOM 98 C THRL 13 9.703 21.053 9.814 1.00 13.88 ATOM 99 O THRL 13 8.766 20.263 10.131 1.00 12.15 ATOM 100 N SERL 14 9.474 22.296 9.389 1.00 8.75 ATOM 102 CA SERL 14 8.119 22.684 9.120 1.00 10.75 ATOM 103 CB SERL 14 7.964 24.220 9.106 1.00 15.90 ATOM 104 OG SERL 14 8.794 24.839 10.126 1.00 21.10 ATOM 106 C SERL 14 7.802 22.124 7.784 1.00 10.99 ATOM 107 O SERL 14 8.703 21.910 6.981 1.00 10.06 ATOM 108 N PROL 15 6.560 21.807 7.514 1.00 11.57 ATOM 109 CD PROL 15 5.417 21.894 8.417 1.00 11.51 ATOM 110 CA PROL 15 6.211 21.264 6.210 1.00 13.73 ATOM ll CB PRO L 15 4.712 20.965 6.322 1.00 12.67 ATOM 112 CG PRO L 15 4.257 21.810 7.463 1.00 13.25 ATOM 113 C PRO L 15 6.562 22.287 5.106 1.00 15.44 ATOM 114 O PROL 15 6.620 23.482 5.388 1.00 14.98 ATOM 115 N GLYL 16 6.849 21.806 3.887 1.00 12.73 ATOM 117 CA GLYL 16 7.184 22.686 2.796 1.00 11.86 ATOM 118 C GLYL 16 8.645 23.047 2.740 1.00 11.99 ATOM 119 O GLYL 16 9.097 23.650 1.786 1.00 16.69 ATOM 120 N GLU L 17 9.405 22.729 3.739 1.00 10.28 ATOM 122 CA GLU L 17 10.801 23.014 3.660 1.00 8.33 ATOM 123 CB GLUL 17 11.319 23.510 5.002 1.00 6.44 ATOM 124 CG GLU L 17 10.648 24.808 5.438 1.00 11.47 ATOM 125 CD GLU L 17 10.766 25.875 4.353 1.00 5.30 ATOM 126 OE1 GLUL 17 11.949 26.218 3.967 1.00 6.09 ATOM 127 OE2 GLU L 17 9.681 26.343 3.900 1.00 7.10 ATOM 128 C GLU L 17 11.553 21.772 3.219 1.00 8.34 ATOM 129 O GLU L 17 10.995 20.665 3.241 1.00 10.48 ATOM 130 N THRL 18 12.821 21.961 2.861 1.00 7.25 ATOM 132 CA THRL 18 13.682 20.866 2.407 1.00 6.74 ATOM 133 CB THRL 18 14.576 21.383 1.236 1.00 3.14 ATOM 134 OG I THRL 18 13.718 21.634 0.084 1.00 2.24 ATOM 136 CG2 THRL 18 15.708 20.418 0.909 1.00 5.50 ATOM 137 C THRL 18 14.587 20.422 3.544 1.00 5.28 ATOM 138 O THRL 18 15.129 21.265 4.271 1.00 4.15 ATOM 139 N VALL 19 14.815 19.121 3.646 1.00 5.05 ATOM 141 CA VALL 19 15.711 18.587 4.662 1.00 6.85 ATOM 142 CB VALL 19 14.934 17.754 5.770 1.00 8.11 ATOM 143 CG1 VALL 19 14.554 18.573 6.983 1.00 12.22 ATOM 144 CG2VALL 19 13.670 17.120 5.170 1.00 11.25 ATOM 145 C VALL 19 16.695 17.609 4.010 1.00 7.00 ATOM 146 0 VALL 19 16.323 16.856 3.123 1.00 8.38 ATOM 147 N THRL 20 17.897 17.588 4.511 1.00 7.91 ATOM 149 CA THRL 20 18.861 16.618 4.098 1.00 10.04 ATOM 150 CB THRL 20 20.046 17.270 3.319 1.00 8.38 ATOM 151 OGI THRL 20 19.553 17.736 2.053 1.00 10.18 ATOM 153 CG2THRL 20 21.188 16.287 3.104 1.00 7.29 ATOM 154 C THRL 20 19.379 15.843 5.324 1.00 10.78 ATOM 155 O THRL 20 19.752 16.441 6.354 1.00 14.77 ATOM 156 N LEUL 21 19.313 14.510 5.201 1.00 8.97 ATOM 158 CA LEUL 21 19.829 13.570 6.174 1.00 5.71 ATOM 159 CB LEUL 21 18.819 12.417 6.324 1.00 7.30 ATOM 160 CG LEUL 21 17.448 12.710 6.922 1.00 3.52 ATOM 161 CDI LEU L 21 16.618 13.549 5.972 1.00 12.30 ATOM 162 CD2LEUL 21 16.726 11.431 7.221 1.00 5.61 ATOM 163 C LEUL 21 21.108 13.008 5.612 1.00 5.00 ATOM 164 O LEU L 21 21.155 12.736 4.403 1.00 6.66 ATOM 165 N THRL 22 22.151 12.817 6.426 1.00 4.47 ATOM 167 CA THRL 22 23.366 12.204 5.920 1.00 8.68 ATOM 168 CB THRL 22 24.593 13.096 6.059 1.00 8.60 WO 99/10379 PCT/GB98/02542 -164 ATOM 169 OGI THR L 22 24.910 13.292 7.446 1.00 13.20 ATOM 171 CG2 THR L 22 24.362 14.415 5.379 1.00 12.92 ATOM 172 C THRL 22 23.674 10.813 6.543 1.00 12.45 ATOM 173 O THRL 22 23.079 10.380 7.573 1.00 12.78 ATOM 174 N CYS L 23 24.608 10.148 5.934 1.00 9.70 ATOM 176 CA CYS L 23 24.952 8.812 6.315 1.00 12.79 ATOM 177 CB CYSL 23 24.114 7.891 5.444 1.0011.70 ATOM 178 SG CYS L 23 24.573 6.172 5.437 1.00 14.38 ATOM 179 C CYS L 23 26.425 8.616 6.085 1.00 11.83 ATOM 180 O CYS L 23 26.880 8.699 4.961 1.00 13.63 ATOM 181 N ARG L 24 27.201 8.397 7.146 1.00 13.74 ATOM 183 CA ARG L 24 28.638 8.236 6.965 1.00 15.34 ATOM 184 CB ARG L 24 29.442 9.275 7.741 1.00 17.58 ATOM 185 CG ARGL 24 29.171 9.346 9.214 1.0023.61 ATOM 186 CD ARG L 24 30.177 10.263 9.890 1.00 27.66 ATOM 187 NE ARG L 24 31.558 9.839 9.613 1.0030.74 ATOM 189 CZ ARG L 24 32.508 10.677 9.195 0.01 28.45 ATOM 190 NHI ARG L 24 33.729 10.222 8.952 0.01 28.77 ATOM 193 NH2 ARG L 24 32.247 11.970 9.031 0.01 27.96 ATOM 196 C ARG L 24 29.123 6.869 7.327 1.00 16.36 ATOM 197 O ARG L 24 28.461 6.146 8.081 1.00 15.58 ATOM 198 N SERL 25 30.274 6.517 6.760 1.00 14.90 ATOM 200 CA SERL 25 30.900 5.237 7.014 1.00 15.33 ATOM 201 CB SERL 25 31.273 4.582 5.683 1.0020.16 ATOM 202 OG SERL 25 32.252 3.571 5.852 1.0023.32 ATOM 204 C SERL 25 32.145 5.470 7.869 1.00 14.75 ATOM 205 O SERL 25 32.859 6.422 7.653 1.00 16.11 ATOM 206 N SERL 26 32.381 4.626 8.851 1.00 15.20 ATOM 208 CA SERL 26 33.555 4.767 9.720 1.00 19.00 ATOM 209 CB SERL 26 33.381 3.884 10.959 1.00 16.96 ATOM 210 OG SERL 26 33.196 2.519 10.578 1.00 19.34 ATOM 212 C SERL 26 34.858 4.349 9.001 1.00 19.93 ATOM 213 O SERL 26 35.936 4.445 9.570 1.00 23.14 ATOM 214 N THRL 27 34.768 3.853 7.781 1.0020.53 ATOM 216 CA THRL 27 35.958 3.362 7.120 1.00 19.87 ATOM 217 CB THRL 27 35.651 2.067 6.419 1.00 21.22 ATOM 218 OGI THRL 27 34.472 2.209 5.633 1.00 24.06 ATOM 220 CG2 THR L 27 35.417 0.987 7.453 1.00 23.05 ATOM 221 C THRL 27 36.536 4.375 6.153 1.00 19.65 ATOM 222 O THR L 27 37.728 4.343 5.822 1.00 20.98 ATOM 223 N GLYL 27A 35.697 5.293 5.715 1.0020.47 ATOM 225 CA GLYL 27A 36.148 6.333 4.827 1.00 15.37 ATOM 226 C GLY L 27A 34.981 6.909 4.102 1.00 14.56 ATOM 227 O GLY L 27A 33.871 6.786 4.564 1.00 16.44 ATOM 228 N ALAL 27B 35.237 7.538 2.959 1.00 14.44 ATOM 230 CA ALA L 27B 34.183 8.158 2.158 1.00 13.84 ATOM 231 CB ALA L 27B 34.801 8.852 0.922 1.00 10.44 ATOM 232 C ALAL 27B 33.157 7.151 1.678 1.00 14.20 ATOM 233 O ALA L 27B 33.507 6.028 1.294 1.00 16.84 ATOM 234 N VALL 27C 31.915 7.550 1.682 1.00 12.61 ATOM 236 CA VALL 27C 30.894 6.755 1.040 1.00 14.17 ATOM 237 CB VALL 27C 29.533 7.077 1.632 1.00 13.42 ATOM 238 CGI VAL L 27C 28.465 6.232 0.979 1.00 14.92 ATOM 239 CG2 VAL L 27C 29.592 6.828 3.130 1.00 14.29 ATOM 240 C VAL L 27C 30.903 7.081 -0.471 1.00 16.22 ATOM 241 0 VALL 27C 30.837 8.264 -0.849 1.00 16.42 ATOM 242 N THRL 28 31.047 6.039 -1.322 1.00 15.73 ATOM 244 CA THRL 28 31.068 6.215 -2.805 1.00 14.38 ATOM 245 CB THRL 28 32.386 5.725 -3.453 1.00 12.94 ATOM 246 OG1 THRL 28 32.412 4.313 -3.470 1.00 13.65 ATOM 248 CG2 THR L 28 33.597 6.211 -2.699 1.00 11.90 ATOM 249 C THR L 28 29.924 5.439 -3.450 1.00 12.92 ATOM 250 O THR L 28 29.103 4.824 -2.764 1.00 9.64 ATOM 251 N THRL 29 29.850 5.474 -4.765 1.00 12.65 ATOM 253 CA THRL 29 28.780 4.786 -5.461 1.00 14.40 ATOM 254 CB THRL 29 28.797 5.088 -6.978 1.00 15.28 ATOM 255 OG1 THR L 29 30.146 4.883 -7.468 1.00 16.73 ATOM 257 CG2 THR L 29 28.337 6.524 -7.253 1.00 16.74 ATOM 258 C THRL 29 28.904 3.287 -5.275 1.00 14.04 ATOM 259 O THRL 29 27.939 2.555 -5.436 1.00 17.19 ATOM 260 N SERL 30 30.085 2.840 -4.924 1.00 14.83 ATOM 262 CA SER L 30 30.306 1.429 -4.697 1.00 16.69 WO 99/10379 PCT/GB98/02542 -165 ATOM 263 CB SERL 30 31.790 1.168 -4.607 1.00 18.52 ATOM 264 OG SERL 30 32.399 1.455 -5.845 1.00 22.73 ATOM 266 C SERL 30 29.628 0.939 -3.418 1.00 18.22 ATOM 267 O SERL 30 29.565 -0.247 -3.177 1.00 17.69 ATOM 268 N ASN L 31 29.154 1.843 -2.585 1.00 16.05 ATOM 270 CA ASN L 31 28.467 1.432 -1.358 1.00 12.29 ATOM 271 CB ASN L 31 28.710 2.456 -0.265 1.00 9.73 ATOM 272 CG ASNL 31 30.118 2.424 0.219 1.00 5.99 ATOM 273 ODI ASN L 31 30.833 3.398 0.117 1.00 9.76 ATOM 274 ND2 ASN L 31 30.548 1.320 0.741 1.00 3.79 ATOM 277 C ASN L 31 26.988 1.277 -1.585 1.00 10.21 ATOM 278 O ASN L 31 26.242 0.937 -0.663 1.00 9.59 ATOM 279 N TYRL 32 26.575 1.527 -2.829 1.00 8.64 ATOM 281 CA TYRL 32 25.176 1.475 -3.211 1.00 7.71 ATOM 282 CB TYRL 32 24.830 0.081 -3.773 1.00 11.29 ATOM 283 CG TYRL 32 25.721 -0.367 -4.925 1.00 11.41 ATOM 284 CDI TYRL 32 27.019 -0.834 -4.681 1.00 14.39 ATOM 285 CEI TYRL 32 27.869 -1.196 -5.711 1.00 14.44 ATOM 286 CD2 TYR L 32 25.296 -0.298 -6.259 1.00 17.67 ATOM 287 CE2 TYR L 32 26.145 -0.666 -7.326 1.00 11.36 ATOM 288 CZ TYRL 32 27.437 -1.108 -7.043 1.00 17.13 ATOM 289 OH TYRL 32 28.334 -1.419 -8.085 1.0021.48 ATOM 291 C TYRL 32 24.228 1.852 -2.055 1.00 11.23 ATOM 292 O TYRL 32 23.288 1.105 -1.733 1.00 6.50 ATOM 293 N ALA L 33 24.445 3.043 -1.455 1.00 11.42 ATOM 295 CA ALAL 33 23.624 3.480 -0.308 1.00 11.19 ATOM 296 CB ALA L 33 23.921 4.926 0.065 1.00 10.80 ATOM 297 C ALA L 33 22.133 3.371 -0.547 1.00 10.34 ATOM 298 O ALA L 33 21.660 3.893 -1.543 1.00 8.45 ATOM 299 N ASN L 34 21.401 2.715 0.396 1.00 7.12 ATOM 301 CA ASNL 34 19.925 2.664 0.367 1.00 5.84 ATOM 302 CB ASNL 34 19.388 1.251 0.564 1.00 3.46 ATOM 303 CG ASN L 34 19.488 0.414 -0.691 1.00 7.07 ATOM 304 ODI ASNL 34 18.487 -0.063 -1.223 1.00 5.20 ATOM 305 ND2 ASN L 34 20.700 0.240 -1.163 1.00 5.40 ATOM 308 C ASNL 34 19.318 3.528 1.458 1.00 5.10 ATOM 309 O ASN L 34 19.964 3.789 2.435 1.00 6.58 ATOM 310 N TRP L 35 18.076 3.957 1.259 1.00 5.01 ATOM 312 CA TRP L 35 17.339 4.694 2.278 1.00 6.70 ATOM 313 CB TRP L 35 17.175 6.215 1.933 1.00 7.73 ATOM 314 CG TRP L 35 18.477 6.997 1.932 1.00 7.11 ATOM 315 CD2TRP L 35 19.075 7.641 3.080 1.00 8.09 ATOM 316 CE2TRPL 35 20.330 8.111 2.697 1.00 5.38 ATOM 317 CE3 TRP L 35 18.654 7.858 4.418 1.00 10.50 ATOM 318 CDI TRPL 35 19.373 7.125 0.894 1.00 4.99 ATOM 319 NE1 TRP L 35 20.472 7.780 1.351 1.00 6.98 ATOM 321 CZ2 TRP L 35 21.206 8.791 3.595 1.00 5.76 ATOM 322 CZ3 TRP L 35 19.526 8.534 5.295 1.00 6.19 ATOM 323 CH2 TRP L 35 20.785 8.990 4.879 1.00 3.95 ATOM 324 C TRP L 35 16.000 4.036 2.414 1.00 6.29 ATOM 325 O TRP L 35 15.314 3.796 1.403 1.00 6.53 ATOM 326 N VALL 36 15.674 3.704 3.665 1.00 5.99 ATOM 328 CA VAL L 36 14.479 2.971 4.045 1.00 5.23 ATOM 329 CB VAL L 36 14.826 1.555 4.651 1.00 6.23 ATOM 330 CG1 VAL L 36 13.540 0.839 5.092 1.00 2.37 ATOM 331 CG2 VAL L 36 15.571 0.693 3.605 1.00 3.99 ATOM 332 C VALL 36 13.692 3.769 5.086 1.00 4.86 ATOM 333 0 VALL 36 14.255 4.313 6.025 1.00 7.07 ATOM 334 N GLN L 37 12.395 3.803 4.906 1.00 5.26 ATOM 336 CA GLNL 37 11.512 4.532 5.786 1.00 10.98 ATOM 337 CB GLNL 37 10.505 5.305 4.967 1.00 10.61 ATOM 338 CG GLN L 37 9.720 6.295 5.788 1.00 10.14 ATOM 339 CD GLN L 37 8.601 6.850 4.987 1.00 15.44 ATOM 340 OE1 GLNL 37 7.787 6.096 4.465 1.00 18.50 ATOM 341 NE2 GLN L 37 8.553 8.166 4.858 1.00 15.77 ATOM 344 C GLNL 37 10.723 3.613 6.694 1.00 11.84 ATOM 345 O GLN L 37 10.134 2.657 6.222 1.00 15.29 ATOM 346 N GLUL 38 10.689 3.945 7.989 1.00 13.42 ATOM 348 CA GLU L 38 9.861 3.213 8.930 1.00 12.58 ATOM 349 CB GLU L 38 10.678 2.719 10.133 1.00 12.59 ATOM 350 CG GLU L 38 9.830 1.991 11.202 1.00 11.75 ATOM 351 CD GLUL 38 10.622 1.505 12.384 1.00 9.26 WO 99/10379 PCT/GB98/02542 -166 ATOM 352 OE1 GLU L 38 11.751 1.915 12.540 1.00 12.30 ATOM 353 OE2 GLU L 38 10.103 0.690 13.161 1.00 17.41 ATOM 354 C GLU L 38 8.719 4.098 9.460 1.00 14.00 ATOM 355 O GLU L 38 8.964 5.098 10.173 1.00 12.02 ATOM 356 N LYSL 39 7.488 3.747 9.117 1.00 13.36 ATOM 358 CA LYS L 39 6.363 4.431 9.687 1.00 15.90 ATOM 359 CB LYS L 39 5.353 4.768 8.628 1.00 14.39 ATOM 360 CG LYS L 39 5.795 5.954 7.803 1.00 15.78 ATOM 361 CD LYS L 39 4.651 6.478 6.961 1.0022.14 ATOM 362 CE LYS L 39 5.167 7.451 5.905 1.0025.73 ATOM 363 NZ LYS L 39 4.106 7.921 4.959 1.0027.82 ATOM 367 C LYS L 39 5.723 3.624 10.838 1.0020.86 ATOM 368 O LYS L 39 5.775 2.359 10.890 1.00 18.39 ATOM 369 N PROL 40 5.128 4.335 11.810 1.0025.47 ATOM 370 CD PRO L 40 4.973 5.792 11.884 1.0028.62 ATOM 371 CA PRO L 40 4.486 3.717 12.952 1.00 28.32 ATOM 372 CB PROL 40 3.528 4.812 13.494 1.0028.73 ATOM 373 CG PROL 40 3.578 5.887 12.458 1.0030.27 ATOM 374 C PRO L 40 3.779 2.403 12.593 1.0028.70 ATOM 375 O PRO L 40 2.898 2.341 11.688 1.0025.53 ATOM 376 N ALAL 41 4.276 1.365 13.295 1.0030.46 ATOM 378 CA ALA L 41 3.803 -0.018 13.225 1.00 28.13 ATOM 379 CB ALAL 41 2.411 -0.129 12.599 1.0029.92 ATOM 380 C ALA L 41 4.789 -0.885 12.485 1.0024.45 ATOM 381 O ALAL 41 4.403 -1.889 11.908 1.0026.51 ATOM 382 N HISL 42 6.069 -0.511 12.499 1.0022.07 ATOM 384 CA HIS L 42 7.079 -1.337 11.853 1.0020.06 ATOM 385 CB HIS L 42 7.082 -2.734 12.472 1.0020.43 ATOM 386 CG HIS L 42 7.624 -2.730 13.832 1.00 17.71 ATOM 387 CD2 HIS L 42 7.030 -2.688 15.058 1.00 17.56 ATOM 388 ND1 HIS L 42 8.958 -2.573 14.058 1.00 21.55 ATOM 390 CE1 HIS L 42 9.230 -2.422 15.333 1.00 19.46 ATOM 391 NE2 HIS L 42 8.081 -2.487 15.944 1.00 17.49 ATOM 393 C HISL 42 6.815 -1.469 10.375 1.00 21.88 ATOM 394 O HIS L 42 7.010 -2.542 9.809 1.00 22.22 ATOM 395 N LEUL 43 6.335 -0.401 9.749 1.0020.03 ATOM 397 CA LEU L 43 6.067 -0.450 8.339 1.00 20.01 ATOM 398 CB LEUL 43 4.849 0.389 8.019 1.0024.58 ATOM 399 CG LEU L 43 3.599 0.015 8.814 1.0027.32 ATOM 400 CD1 LEUL 43 2.559 1.122 8.684 1.00 26.38 ATOM 401 CD2 LEU L 43 3.071 -1.374 8.380 1.00 24.37 ATOM 402 C LEUL 43 7.271 0.088 7.621 1.00 18.27 ATOM 403 O LEU L 43 7.582 1.270 7.742 1.00 18.64 ATOM 404 N PHE L 44 7.977 -0.790 6.930 1.00 17.14 ATOM 406 CA PHEL 44 9.188 -0.404 6.239 1.00 13.89 ATOM 407 CB PHEL 44 10.276 -1.395 6.558 1.00 10.76 ATOM 408 CG PHEL 44 10.863 -1.268 7.932 1.00 8.20 ATOM 409 CD1 PHE L 44 10.285 -1.925 9.005 1.00 10.99 ATOM 410 CD2 PHEL 44 12.017 -0.526 8.135 1.00 13.17 ATOM 411 CEI PHEL 44 10.834 -1.852 10.273 1.00 11.48 ATOM 412 CE2 PHE L 44 12.588 -0.445 9.399 1.00 12.05 ATOM 413 CZ PHEL 44 11.987 -1.110 10.476 1.00 12.67 ATOM 414 C PHEL 44 8.981 -0.332 4.726 1.00 14.13 ATOM 415 O PHEL 44 8.262 -1.129 4.142 1.00 14.69 ATOM 416 N THRL 45 9.634 0.619 4.092 1.00 14.63 ATOM 418 CA THRL 45 9.508 0.771 2.678 1.00 12.14 ATOM 419 CB THRL 45 8.295 1.652 2.352 1.00 14.73 ATOM 420 OG1 THRL 45 8.083 1.684 0.944 1.00 25.05 ATOM 422 CG2 THRL 45 8.519 3.065 2.828 1.00 19.97 ATOM 423 C THRL 45 10.773 1.398 2.181 1.00 11.69 ATOM 424 O THRL 45 11.316 2.253 2.826 1.00 9.53 ATOM 425 N GLYL 46 11.293 0.878 1.083 1.0011.34 ATOM 427 CA GLYL 46 12.521 1.398 0.526 1.00 7.20 ATOM 428 C GLYL 46 12.252 2.593 -0.331 1.00 7.78 ATOM 429 O GLYL 46 11.283 2.595 -1.140 1.00 10.42 ATOM 430 N LEU L 47 13.092 3.602 -0.166 1.00 7.54 ATOM 432 CA LEUL 47 12.929 4.861 -0.890 1.00 7.47 ATOM 433 CB LEU L 47 13.071 6.050 0.080 1.00 6.90 ATOM 434 CG LEU L 47 12.253 5.969 1.362 1.00 6.26 ATOM 435 CDI LEU L 47 12.782 6.944 2.383 1.00 11.14 ATOM 436 CD2 LEU L 47 10.785 6.173 1.052 1.00 2.41 ATOM 437 C LEU L 47 13.968 4.989 -2.015 1.00 5.84 WO 99/10379 PCT/GB98/02542 -167 ATOM 438 O LEU L 47 13.597 5.286 -3.141 1.00 8.92 ATOM 439 N ILEL 48 15.239 4.746 -1.673 1.00 9.03 ATOM 441 CA ILE L 48 16.377 4.909 -2.566 1.00 7.03 ATOM 442 CB ILE L 48 17.287 6.078 -2.094 1.00 7.21 ATOM 443 CG2 ILE L 48 18.552 6.176 -2.934 1.00 9.51 ATOM 444 CGI ILE L 48 16.524 7.405 -2.047 1.00 8.82 ATOM 445 CD ILEL 48 16.013 7.933 -3.364 1.00 7.80 ATOM 446 C ILE L 48 17.245 3.644 -2.530 1.00 8.61 ATOM 447 O ILEL 48 17.458 3.068 -1.462 1.00 10.60 ATOM 448 N GLY L 49 17.755 3.237 -3.704 1.00 7.04 ATOM 450 CA GLY L 49 18.697 2.142 -3.805 1.00 2.00 ATOM 451 C GLY L 49 19.833 2.550 -4.716 1.00 7.57 ATOM 452 O GLY L 49 19.716 3.479 -5.538 1.00 14.41 ATOM 453 N GLY L 50 20.941 1.930 -4.590 1.00 9.91 ATOM 455 CA GLY L 50 22.036 2.293 -5.431 1.00 9.21 ATOM 456 C GLY L 50 22.299 3.789 -5.458 1.00 12.31 ATOM 457 O GLY L 50 22.341 4.370 -6.518 1.00 12.48 ATOM 458 N THRL 51 22.465 4.390 -4.284 1.00 10.33 ATOM 460 CA THRL 51 22.795 5.834 -4.116 1.00 12.06 ATOM 461 CB THRL 51 24.092 6.281 -4.869 1.00 11.87 ATOM 462 OGI THRL 51 25.226 5.464 -4.501 1.00 7.57 ATOM 464 CG2THRL 51 24.409 7.726 -4.514 1.00 11.63 ATOM 465 C THRL 51 21.672 6.817 -4.460 1.00 11.67 ATOM 466 O THRL 51 21.343 7.660 -3.638 1.00 11.93 ATOM 467 N ASN L 52 21.046 6.703 -5.637 1.00 12.21 ATOM 469 CA ASNL 52 20.092 7.718 -6.054 1.00 13.73 ATOM 470 CB ASN L 52 20.824 8.824 -6.808 1.00 18.43 ATOM 471 CG ASNL 52 21.621 8.271 -7.967 1.0024.37 ATOM 472 OD1 ASN L 52 21.164 7.364 -8.639 1.00 22.65 ATOM 473 ND2 ASN L 52 22.842 8.774 -8.182 1.00 28.21 ATOM 476 C ASNL 52 18.964 7.205 -6.914 1.00 15.37 ATOM 477 O ASNL 52 18.318 7.975 -7.594 1.00 13.37 ATOM 478 N ASN L 53 18.730 5.916 -6.901 1.00 16.28 ATOM 480 CA ASN L 53 17.652 5.350 -7.676 1.00 17.34 ATOM 481 CB ASN L 53 18.079 3.979 -8.239 1.00 24.00 ATOM 482 CG ASNL 53 17.187 3.406 -9.349 1.0027.36 ATOM 483 ODI ASN L 53 17.659 2.594 -10.168 1.0033.10 ATOM 484 ND2ASNL 53 15.911 3.799 -9.410 1.0031.42 ATOM 487 C ASNL 53 16.415 5.210 -6.781 1.00 17.91 ATOM 488 O ASN L 53 16.352 4.394 -5.893 1.00 18.29 ATOM 489 N ARG L 54 15.447 6.010 -7.022 1.00 15.93 ATOM 491 CA ARG L 54 14.283 5.977 -6.241 1.00 18.87 ATOM 492 CB ARG L 54 13.500 7.233 -6.541 1.0022.33 ATOM 493 CG ARG L 54 12.109 7.273 -5.975 1.0025.55 ATOM 494 CD ARG L 54 11.778 8.681 -5.615 1.0029.54 ATOM 495 NE ARG L 54 12.126 9.582 -6.671 1.0027.82 ATOM 497 CZ ARGL 54 11.288 9.890 -7.630 1.0032.19 ATOM 498 NH1 ARG L 54 11.669 10.739 -8.561 1.00 35.27 ATOM 501 NH2 ARG L 54 10.071 9.344 -7.673 1.00 31.58 ATOM 504 C ARG L 54 13.483 4.725 -6.552 1.0021.41 ATOM 505 O ARG L 54 13.273 4.403 -7.738 1.0021.21 ATOM 506 N ALAL 55 13.061 4.010 -5.489 1.0020.79 ATOM 508 CA ALA L 55 12.237 2.803 -5.629 1.00 21.50 ATOM 509 CB ALA L 55 12.004 2.154 -4.262 1.00 18.92 ATOM 510 C ALAL 55 10.932 3.185 -6.282 1.0022.01 ATOM 511 O ALAL 55 10.488 4.307 -6.147 1.0023.44 ATOM 512 N PROL 56 10.264 2.268 -6.972 1.0025.55 ATOM 513 CD PRO L 56 10.602 0.823 -7.094 1.00 26.77 ATOM 514 CA PROL 56 9.019 2.583 -7.664 1.0024.82 ATOM 515 CB PROL 56 8.690 1.270 -8.406 1.0027.53 ATOM 516 CG PRO L 56 9.286 0.224 -7.522 1.00 27.71 ATOM 517 C PROL 56 7.914 3.046 -6.720 1.00 25.91 ATOM 518 O PROL 56 7.749 2.531 -5.608 1.0026.27 ATOM 519 N GLY L 57 7.148 4.025 -7.182 1.0026.28 ATOM 521 CA GLY L 57 6.054 4.562 -6.382 1.00 22.74 ATOM 522 C GLY L 57 6.486 5.620 -5.373 1.00 20.96 ATOM 523 O GLYL 57 5.666 6.381 -4.908 1.0023.79 ATOM 524 N VAL L 58 7.764 5.662 -5.014 1.0020.25 ATOM 526 CA VALL 58 8.231 6.660 -4.079 1.00 18.53 ATOM 527 CB VAL L 58 9.680 6.382 -3.699 1.00 15.29 ATOM 528 CGI VALL 58 10.238 7.551 -2.940 1.00 11.07 ATOM 529 CG2 VAL L 58 9.750 5.103 -2.874 1.00 12.65 WO 99/10379 PCT/GB98/02542 -168 ATOM 530 C VALL 58 8.119 8.077 -4.675 1.0022.04 ATOM 531 0 VALL 58 8.583 8.324 -5.803 1.0022.18 ATOM 532 N PRO L 59 7.524 9.045 -3.894 1.00 21.50 ATOM 533 CD PRO L 59 6.983 8.863 -2.521 1.0020.50 ATOM 534 CA PRO L 59 7.336 10.449 -4.315 1.00 17.94 ATOM 535 CB PRO L 59 6.841 11.133 -3.057 1.00 18.92 ATOM 536 CG PRO L 59 6.054 10.043 -2.414 1.00 18.97 ATOM 537 C PRO L 59 8.583 11.092 -4.837 1.00 16.82 ATOM 538 O PROL 59 9.706 10.918 -4.311 1.00 15.46 ATOM 539 N ALA L 60 8.370 11.873 -5.854 1.00 13.05 ATOM 541 CA ALA L 60 9.447 12.523 -6.521 1.00 14.83 ATOM 542 CB ALA L 60 8.871 13.289 -7.696 1.00 14.69 ATOM 543 C ALA L 60 10.233 13.424 -5.570 1.00 13.44 ATOM 544 O ALA L 60 11.407 13.633 -5.776 1.00 12.14 ATOM 545 N ARG L 61 9.593 13.928 -4.489 1.00 15.30 ATOM 547 CA ARG L 61 10.309 14.825 -3.522 1.00 12.59 ATOM 548 CB ARG L 61 9.349 15.408 -2.470 1.00 11.72 ATOM 549 CG ARG L 61 8.620 14.397 -1.586 1.00 14.79 ATOM 550 CD ARG L 61 7.890 15.077 -0.419 1.00 14.00 ATOM 551 NE ARGL 61 7.226 14.114 0.476 1.00 10.99 ATOM 553 CZ ARGL 61 6.131 13.465 0.114 1.00 11.79 ATOM 554 NH1 ARG L 61 5.556 12.582 0.908 1.00 10.75 ATOM 557 NH2 ARG L 61 5.624 13.684 -1.059 1.00 9.70 ATOM 560 C ARGL 61 11.500 14.173 -2.811 1.00 12.82 ATOM 561 O ARGL 61 12.291 14.876 -2.112 1.00 14.41 ATOM 562 N PHE L 62 11.649 12.845 -2.959 1.00 11.27 ATOM 564 CA PHEL 62 12.749 12.133 -2.305 1.00 10.94 ATOM 565 CB PHEL 62 12.274 10.739 -1.775 1.00 9.35 ATOM 566 CG PHE L 62 11.263 10.787 -0.649 1.00 9.62 ATOM 567 CDI PHEL 62 11.683 10.906 0.690 1.00 5.49 ATOM 568 CD2 PHE L 62 9.897 10.704 -0.919 1.00 6.68 ATOM 569 CE1 PHEL 62 10.760 10.943 1.698 1.00 2.51 ATOM 570 CE2PHEL 62 8.968 10.742 0.110 1.00 7.73 ATOM 571 CZ PHEL 62 9.399 10.864 1.419 1.00 4.66 ATOM 572 C PHEL 62 13.914 11.938 -3.265 1.00 9.16 ATOM 573 O PHEL 62 13.692 11.429 -4.340 1.00 8.82 ATOM 574 N SERL 63 15.160 12.325 -2.864 1.00 4.85 ATOM 576 CA SERL 63 16.307 12.112 -3.733 1.00 8.59 ATOM 577 CB SERL 63 16.671 13.353 -4.534 1.00 7.17 ATOM 578 OG SERL 63 17.269 14.319 -3.694 1.00 12.90 ATOM 580 C SERL 63 17.511 11.689 -2.946 1.00 7.30 ATOM 581 O SERL 63 17.703 12.187 -1.852 1.00 9.45 ATOM 582 N GLYL 64 18.286 10.728 -3.503 1.00 5.56 ATOM 584 CA GLY L 64 19.495 10.269 -2.889 1.00 4.07 ATOM 585 C GLY L 64 20.676 10.881 -3.568 1.00 9.49 ATOM 586 O GLY L 64 20.620 11.246 -4.766 1.00 12.20 ATOM 587 N SERL 65 21.758 11.031 -2.872 1.00 6.73 ATOM 589 CA SERL 65 22.865 11.665 -3.485 1.00 9.75 ATOM 590 CB SERL 65 22.581 13.171 -3.683 1.00 8.17 ATOM 591 OG SERL 65 22.791 13.906 -2.475 1.00 10.45 ATOM 593 C SER L 65 24.064 11.437 -2.652 1.00 10.16 ATOM 594 O SERL 65 23.978 10.692 -1.662 1.00 10.96 ATOM 595 N LEUL 66 25.182 12.009 -3.085 1.00 10.68 ATOM 597 CA LEU L 66 26.453 11.877 -2.394 1.00 9.69 ATOM 598 CB LEUL 66 27.441 11.114 -3.317 1.00 13.61 ATOM 599 CG LEUL 66 28.218 9.861 -2.820 1.00 9.87 ATOM 600 CD1 LEU L 66 27.385 8.987 -1.932 1.00 8.09 ATOM 601 CD2 LEU L 66 28.680 9.048 -4.022 1.00 8.69 ATOM 602 C LEUL 66 26.918 13.316 -2.147 1.00 12.92 ATOM 603 O LEU L 66 27.054 14.087 -3.082 1.00 10.87 ATOM 604 N ILE L 67 27.091 13.694 -0.865 1.00 12.45 ATOM 606 CA ILEL 67 27.534 15.048 -0.518 1.00 11.66 ATOM 607 CB ILE L 67 26.437 15.786 0.334 1.00 12.96 ATOM 608 CG2 ILE L 67 26.820 17.222 0.568 1.00 13.30 ATOM 609 CGI ILE L 67 25.074 15.750 -0.357 1.00 13.53 ATOM 610 CD ILEL 67 23.962 16.437 0.419 1.00 11.05 ATOM 611 C ILEL 67 28.837 14.913 0.268 1.00 12.31 ATOM 612 O ILEL 67 28.856 14.332 1.339 1.00 13.03 ATOM 613 N GLY L 68 29.946 15.384 -0.274 1.00 13.08 ATOM 615 CA GLY L 68 31.199 15.196 0.416 1.00 12.32 ATOM 616 C GLYL 68 31.463 13.701 0.568 1.00 17.92 ATOM 617 O GLY L 68 31.201 12.934 -0.393 1.00 16.67 WO 99/10379 PCT/GB98/02542 -169 ATOM 618 N ASP L 69 31.962 13.259 1.747 1.00 16.48 ATOM 620 CA ASPL 69 32.244 11.827 1.941 1.00 18.10 ATOM 621 CB ASP L 69 33.350 11.576 2.960 1.00 24.05 ATOM 622 CG ASP L 69 34.617 12.363 2.730 1.00 31.27 ATOM 623 ODI ASP L 69 35.202 12.302 1.597 1.00 32.40 ATOM 624 OD2 ASP L 69 35.038 13.053 3.707 1.00 39.08 ATOM 625 C ASPL 69 31.040 11.041 2.429 1.00 14.56 ATOM 626 0 ASPL 69 31.213 9.925 2.886 1.00 16.00 ATOM 627 N LYSL 70 29.837 11.573 2.321 1.00 11.13 ATOM 629 CA LYS L 70 28.693 10.853 2.847 1.00 11.46 ATOM 630 CB LYS L 70 28.125 11.600 4.028 1.00 11.39 ATOM 631 CG LYSL 70 29.012 11.550 5.248 1.00 18.50 ATOM 632 CD LYS L 70 28.263 12.078 6.455 1.0020.15 ATOM 633 CE LYS L 70 28.152 13.574 6.391 1.0022.74 ATOM 634 NZ LYS L 70 29.502 14.187 6.360 1.0027.69 ATOM 638 C LYS L 70 27.593 10.635 1.869 1.00 10.75 ATOM 639 O LYSL 70 27.478 11.366 0.879 1.00 11.35 ATOM 640 N ALAL 71 26.759 9.619 2.144 1.00 6.32 ATOM 642 CA ALA L 71 25.537 9.475 1.385 1.00 2.44 ATOM 643 CB ALA L 71 25.056 8.033 1.399 1.00 2.00 ATOM 644 C ALA L 71 24.483 10.396 2.027 1.00 6.77 ATOM 645 O ALAL 71 24.518 10.670 3.253 1.00 6.10 ATOM 646 N ALA L 72 23.557 10.888 1.235 1.00 5.00 ATOM 648 CA ALA L 72 22.570 11.814 1.741 1.00 6.21 ATOM 649 CB ALA L 72 23.042 13.257 1.524 1.00 3.82 ATOM 650 C ALAL 72 21.215 11.570 1.100 1.00 4.44 ATOM 651 O ALAL 72 21.109 11.043 -0.045 1.00 6.60 ATOM 652 N LEUL 73 20.186 11.854 1.883 1.00 5.08 ATOM 654 CA LEUL 73 18.799 11.765 1.446 1.00 4.01 ATOM 655 CB LEU L 73 17.970 10.823 2.319 1.00 4.42 ATOM 656 CG LEU L 73 16.494 10.793 1.959 1.00 4.74 ATOM 657 CD1 LEU L 73 16.290 9.999 0.667 1.00 4.42 ATOM 658 CD2LEUL 73 15.684 10.194 3.100 1.00 8.67 ATOM 659 C LEUL 73 18.198 13.141 1.576 1.00 5.38 ATOM 660 0 LEUL 73 18.297 13.756 2.622 1.00 9.62 ATOM 661 N THRL 74 17.617 13.635 0.531 1.00 7.72 ATOM 663 CA THR L 74 17.024 14.935 0.566 1.00 6.80 ATOM 664 CB THRL 74 17.721 15.910 -0.447 1.00 9.87 ATOM 665 OGI THRL 74 19.099 16.158 -0.011 1.00 4.69 ATOM 667 CG2 THRL 74 16.961 17.216 -0.538 1.00 4.65 ATOM 668 C THRL 74 15.593 14.857 0.275 1.00 7.31 ATOM 669 0 THRL 74 15.182 14.221 -0.672 1.00 6.60 ATOM 670 N ILEL 75 14.816 15.472 1.136 1.00 8.15 ATOM 672 CA ILEL 75 13.413 15.560 0.923 1.00 9.10 ATOM 673 CB ILEL 75 12.620 15.131 2.171 1.00 11.95 ATOM 674 CG2 ILE L 75 11.148 15.053 1.822 1.00 12.49 ATOM 675 CG1 ILE L 75 13.146 13.794 2.729 1.00 16.99 ATOM 676 CD ILEL 75 12.335 13.263 3.909 1.00 15.52 ATOM 677 C ILEL 75 13.092 17.018 0.628 1.00 12.05 ATOM 678 O ILEL 75 13.192 17.866 1.520 1.00 10.42 ATOM 679 N THRL 76 12.722 17.309 -0.627 1.00 13.27 ATOM 681 CA THRL 76 12.393 18.674 -1.039 1.00 11.86 ATOM 682 CB THRL 76 12.724 18.884 -2.519 1.00 8.49 ATOM 683 OGI THRL 76 14.092 18.564 -2.749 1.00 7.34 ATOM 685 CG2 THR L 76 12.480 20.309 -2.892 1.00 8.93 ATOM 686 C THR L 76 10.907 18.987 -0.848 1.00 15.75 ATOM 687 O THRL 76 10.051 18.407 -1.523 1.00 19.95 ATOM 688 N GLY L 77 10.593 19.939 0.038 1.00 17.30 ATOM 690 CA GLY L 77 9.197 20.267 0.278 1.00 15.95 ATOM 691 C GLYL 77 8.573 19.198 1.109 1.00 16.40 ATOM 692 O GLYL 77 7.498 18.704 0.788 1.00 17.47 ATOM 693 N ALA L 78 9.247 18.836 2.189 1.00 16.13 ATOM 695 CA ALA L 78 8.771 17.740 3.065 1.00 16.88 ATOM 696 CB ALA L 78 9.672 17.614 4.284 1.00 15.72 ATOM 697 C ALA L 78 7.304 17.900 3.476 1.00 17.09 ATOM 698 O ALA L 78 6.803 19.006 3.676 1.0020.02 ATOM 699 N GLNL 79 6.596 16.779 3.543 1.00 16.23 ATOM 701 CA GLN L 79 5.203 16.781 3.933 1.00 14.31 ATOM 702 CB GLN L 79 4.426 16.047 2.865 1.00 13.55 ATOM 703 CG GLN L 79 4.481 16.789 1.539 1.00 17.28 ATOM 704 CD GLN L 79 3.673 16.137 0.434 1.0022.72 ATOM 705 OEI GLNL 79 3.812 16.511 -0.749 1.00 28.20 WO 99/10379 PCT/GB98/02542 -170 ATOM 706 NE2 GLN L 79 2.814 15.173 0.777 1.00 22.58 ATOM 709 C GLN L 79 4.997 16.154 5.332 1.00 14.89 ATOM 710 O GLN L 79 5.885 15.484 5.845 1.00 14.38 ATOM 711 N THRL 80 3.836 16.376 5.932 1.00 12.50 ATOM 713 CA THRL 80 3.593 15.907 7.302 1.00 18.91 ATOM 714 CB THRL 80 2.233 16.385 7.818 1.00 17.20 ATOM 715 OGI THRL 80 1.228 15.959 6.895 1.00 21.04 ATOM 717 CG2THRL 80 2.207 17.905 7.935 1.00 19.65 ATOM 718 C THRL 80 3.631 14.391 7.375 1.00 19.00 ATOM 719 O THRL 80 4.022 13.822 8.414 1.00 21.72 ATOM 720 N GLU L 81 3.227 13.766 6.258 1.00 18.63 ATOM 722 CA GLUL 81 3.239 12.330 6.113 1.00 19.81 ATOM 723 CB GLUL 81 2.562 11.959 4.811 1.0024.17 ATOM 724 CG GLU L 81 3.364 12.403 3.595 1.00 34.44 ATOM 725 CD GLUL 81 2.692 12.102 2.262 1.0040.56 ATOM 726 OE1 GLU L 81 1.653 12.768 1.948 1.0044.10 ATOM 727 OE2GLUL 81 3.204 11.208 1.517 1.0043.81 ATOM 728 C GLUL 81 4.662 11.783 6.107 1.00 18.55 ATOM 729 O GLUL 81 4.842 10.589 6.074 1.0020.36 ATOM 730 N ASPL 82 5.677 12.654 6.111 1.00 14.45 ATOM 732 CA ASP L 82 7.037 12.191 6.090 1.00 11.96 ATOM 733 CB ASP L 82 7.919 13.129 5.269 1.00 11.90 ATOM 734 CG ASP L 82 7.522 13.200 3.796 1.00 13.46 ATOM 735 ODI ASP L 82 6.770 12.333 3.312 1.00 16.83 ATOM 736 OD2 ASPL 82 7.942 14.138 3.146 1.00 13.86 ATOM 737 C ASP L 82 7.618 12.080 7.489 1.00 12.84 ATOM 738 O ASP L 82 8.815 11.743 7.640 1.00 9.40 ATOM 739 N GLU L 83 6.854 12.472 8.523 1.00 13.25 ATOM 741 CA GLU L 83 7.368 12.247 9.879 1.00 13.46 ATOM 742 CB GLU L 83 6.377 12.778 10.935 1.00 17.14 ATOM 743 CG GLU L 83 6.860 12.654 12.394 1.00 21.93 ATOM 744 CD GLU L 83 6.084 13.563 13.357 1.0026.14 ATOM 745 OE1 GLU L 83 5.765 14.702 12.969 1.0022.27 ATOM 746 OE2GLUL 83 5.784 13.135 14.508 1.0027.48 ATOM 747 C GLU L 83 7.524 10.722 9.983 1.00 9.35 ATOM 748 O GLU L 83 6.546 9.998 9.788 1.00 12.41 ATOM 749 N ALA L 84 8.726 10.256 10.222 1.00 9.86 ATOM 751 CA ALAL 84 8.997 8.822 10.227 1.00 8.78 ATOM 752 CB ALA L 84 8.687 8.250 8.849 1.00 7.20 ATOM 753 C ALA L 84 10.444 8.637 10.557 1.00 8.36 ATOM 754 O ALAL 84 11.129 9.618 10.780 1.00 11.79 ATOM 755 N ILEL 85 10.930 7.406 10.620 1.00 8.82 ATOM 757 CA ILE L 85 12.365 7.197 10.876 1.00 7.36 ATOM 758 CB ILEL 85 12.576 6.149 11.967 1.00 5.25 ATOM 759 CG2 ILE L 85 14.058 5.950 12.279 1.00 9.66 ATOM 760 CG1 ILEL 85 11.829 6.632 13.216 1.00 13.36 ATOM 761 CD ILE L 85 11.520 5.579 14.233 1.00 10.12 ATOM 762 C ILE L 85 12.980 6.752 9.547 1.00 5.85 ATOM 763 O ILEL 85 12.301 6.101 8.761 1.00 6.76 ATOM 764 N TYRL 86 14.179 7.216 9.269 1.00 4.42 ATOM 766 CA TYRL 86 14.865 6.907 7.980 1.00 7.23 ATOM 767 CB TYRL 86 15.171 8.183 7.182 1.00 6.83 ATOM 768 CG TYRL 86 13.929 8.853 6.706 1.00 8.61 ATOM 769 CD1 TYRL 86 13.203 9.680 7.591 1.00 5.73 ATOM 770 CEI TYRL 86 11.959 10.169 7.242 1.00 8.65 ATOM 771 CD2TYRL 86 13.378 8.552 5.435 1.00 5.92 ATOM 772 CE2TYRL 86 12.118 9.046 5.095 1.00 6.08 ATOM 773 CZ TYRL 86 11.411 9.853 6.010 1.00 8.14 ATOM 774 OH TYRL 86 10.125 10.288 5.715 1.00 6.40 ATOM 776 C TYRL 86 16.156 6.236 8.237 1.00 2.00 ATOM 777 O TYR L 86 16.988 6.765 8.973 1.00 8.00 ATOM 778 N PHEL 87 16.316 5.060 7.681 1.00 5.92 ATOM 780 CA PHEL 87 17.574 4.313 7.849 1.00 4.34 ATOM 781 CB PHEL 87 17.276 2.846 8.207 1.00 8.38 ATOM 782 CG PHEL 87 16.579 2.690 9.499 1.00 9.99 ATOM 783 CDI PHE L 87 17.303 2.497 10.645 1.00 6.06 ATOM 784 CD2 PHE L 87 15.190 2.725 9.551 1.00 13.30 ATOM 785 CEl PHEL 87 16.642 2.328 11.868 1.00 10.61 ATOM 786 CE2 PHE L 87 14.523 2.562 10.757 1.00 14.04 ATOM 787 CZ PHEL 87 15.261 2.361 11.919 1.00 8.48 ATOM 788 C PHEL 87 18.331 4.301 6.563 1.00 3.22 ATOM 789 O PHEL 87 17.698 4.278 5.518 1.00 2.51 WO 99/10379 PCT/GB98/02542 -171 ATOM 790 N CYS L 88 19.647 4.308 6.639 1.00 5.93 ATOM 792 CA CYS L 88 20.437 4.146 5.446 1.00 9.35 ATOM 793 CB CYS L 88 21.402 5.306 5.236 1.00 5.49 ATOM 794 SG CYS L 88 22.756 5.378 6.415 1.00 15.50 ATOM 795 C CYS L 88 21.214 2.859 5.589 1.00 8.53 ATOM 796 O CYS L 88 21.502 2.427 6.714 1.00 8.84 ATOM 797 N ALA L 89 21.496 2.220 4.494 1.00 8.42 ATOM 799 CA ALA L 89 22.252 0.975 4.532 1.00 8.94 ATOM 800 CB ALA L 89 21.301 -0.198 4.197 1.00 6.42 ATOM 801 C ALA L 89 23.390 1.092 3.510 1.00 11.22 ATOM 802 O ALA L 89 23.172 1.603 2.416 1.00 10.12 ATOM 803 N LEU L 90 24.596 0.666 3.877 1.00 12.71 ATOM 805 CA LEU L 90 25.735 0.737 2.984 1.00 12.28 ATOM 806 CB LEU L 90 26.856 1.594 3.591 1.00 13.85 ATOM 807 CG LEU L 90 26.572 3.096 3.773 1.00 10.32 ATOM 808 CD1 LEU L 90 27.881 3.801 4.146 1.00 7.96 ATOM 809 CD2 LEU L 90 25.963 3.678 2.485 1.00 10.49 ATOM 810 C LEU L 90 26.279 -0.668 2.683 1.00 14.32 ATOM 811 O LEUL 90 26.363 -1.520 3.607 1.00 14.08 ATOM 812 N TRPL 91 26.664 -0.881 1.385 1.00 10.21 ATOM 814 CA TRP L 91 27.175 -2.175 0.892 1.00 9.56 ATOM 815 CB TRP L 91 26.710 -2.415 -0.556 1.00 13.24 ATOM 816 CG TRP L 91 27.344 -3.582 -1.305 1.00 16.93 ATOM 817 CD2 TRP L 91 26.959 -5.000 -1.258 1.00 18.28 ATOM 818 CE2 TRP L 91 27.643 -5.656 -2.300 1.00 18.63 ATOM 819 CE3 TRP L 91 26.093 -5.774 -0.450 1.00 18.52 ATOM 820 CD1 TRP L 91 28.238 -3.469 -2.337 1.00 18.74 ATOM 821 NEI TRP L 91 28.401 -4.692 -2.918 1.00 18.84 ATOM 823 CZ2 TRP L 91 27.502 -7.049 -2.570 1.00 17.39 ATOM 824 CZ3 TRP L 91 25.947 -7.155 -0.717 1.00 20.45 ATOM 825 CH2 TRP L 91 26.658 -7.779 -1.778 1.00 18.96 ATOM 826 C TRPL 91 28.657 -2.194 0.947 1.00 8.96 ATOM 827 O TRP L 91 29.308 -1.254 0.489 1.00 9.38 ATOM 828 N TYRL 92 29.194 -3.229 1.552 1.00 9.41 ATOM 830 CA TYRL 92 30.624 -3.377 1.642 1.00 10.88 ATOM 831 CB TYRL 92 31.083 -3.349 3.115 1.00 13.13 ATOM 832 CG TYR L 92 30.867 -2.023 3.840 1.00 12.25 ATOM 833 CD1 TYRL 92 29.721 -1.780 4.606 1.00 15.61 ATOM 834 CE1 TYRL 92 29.514 -0.552 5.234 1.00 11.01 ATOM 835 CD2TYRL 92 31.808 -1.003 3.741 1.00 14.35 ATOM 836 CE2 TYRL 92 31.607 0.208 4.358 1.00 12.95 ATOM 837 CZ TYRL 92 30.464 0.437 5.090 1.00 11.34 ATOM 838 OH TYRL 92 30.246 1.701 5.613 1.00 14.51 ATOM 840 C TYRL 92 31.048 -4.687 0.967 1.00 15.14 ATOM 841 O TYRL 92 31.339 -5.693 1.650 1.00 14.53 ATOM 842 N SERL 93 31.013 -4.663 -0.383 1.00 16.81 ATOM 844 CA SERL 93 31.449 -5.786 -1.249 1.00 18.41 ATOM 845 CB SERL 93 32.878 -6.169 -0.907 1.00 19.53 ATOM 846 OG SERL 93 33.736 -5.094 -1.258 1.00 25.55 ATOM 848 C SERL 93 30.564 -7.029 -1.238 1.00 20.20 ATOM 849 O SERL 93 30.249 -7.587 -2.322 1.00 17.43 ATOM 850 N ASN L 94 30.202 -7.492 -0.025 1.00 19.09 ATOM 852 CA ASNL 94 29.415 -8.690 0.109 1.00 19.31 ATOM 853 CB ASN L 94 30.341 -9.916 0.037 1.00 18.06 ATOM 854 CG ASNL 94 31.359 -9.928 1.153 1.0022.80 ATOM 855 ODI ASNL 94 31.378 -9.025 2.026 1.00 22.03 ATOM 856 ND2ASN L 94 32.210 -10.949 1.157 1.0021.52 ATOM 859 C ASN L 94 28.595 -8.688 1.403 1.00 20.27 ATOM 860 O ASN L 94 28.147 -9.737 1.863 1.0022.39 ATOM 861 N HIS L 95 28.396 -7.508 1.999 1.00 19.53 ATOM 863 CA HIS L 95 27.529 -7.400 3.161 1.00 18.65 ATOM 864 CB HIS L 95 28.237 -7.853 4.407 1.00 16.28 ATOM 865 CG HIS L 95 29.404 -7.005 4.792 1.00 19.96 ATOM 866 CD2 HIS L 95 30.622 -6.861 4.235 1.00 17.79 ATOM 867 ND1 HIS L 95 29.430 -6.221 5.938 1.00 20.98 ATOM 869 CEl HIS L 95 30.606 -5.630 6.085 1.00 22.66 ATOM 870 NE2 HIS L 95 31.326 -6.018 5.055 1.00 20.00 ATOM 872 C HIS L 95 27.016 -5.983 3.353 1.00 17.00 ATOM 873 O HIS L 95 27.555 -5.053 2.798 1.00 16.62 ATOM 874 N TRPL 96 25.973 -5.841 4.146 1.00 15.07 ATOM 876 CA TRP L 96 25.375 -4.539 4.379 1.00 13.84 ATOM 877 CB TRP L 96 23.874 -4.536 4.055 1.00 12.09 WO 99/10379 PCT/GB98/02542 -172 ATOM 878 CG TRP L 96 23.538 -4.737 2.603 1.00 14.83 ATOM 879 CD2 TRP L 96 23.352 -3.708 1.608 1.00 12.10 ATOM 880 CE2 TRP L 96 22.935 -4.340 0.424 1.00 13.36 ATOM 881 CE3 TRPL 96 23.490 -2.310 1.610 1.00 11.19 ATOM 882 CDI TRPL 96 23.243 -5.913 1.998 1.00 15.53 ATOM 883 NEI TRP L 96 22.883 -5.675 0.705 1.00 14.17 ATOM 885 CZ2 TRP L 96 22.659 -3.631 -0.762 1.00 9.46 ATOM 886 CZ3 TRP L 96 23.208 -1.605 0.441 1.00 7.52 ATOM 887 CH2 TRP L 96 22.800 -2.264 -0.725 1.00 11.56 ATOM 888 C TRP L 96 25.495 -4.170 5.810 1.00 14.61 ATOM 889 O TRPL 96 25.427 -5.064 6.666 1.00 12.87 ATOM 890 N VALL 97 25.684 -2.861 6.040 1.00 11.97 ATOM 892 CA VAL L 97 25.622 -2.286 7.380 1.00 13.35 ATOM 893 CB VAL L 97 26.975 -1.797 7.840 1.00 12.63 ATOM 894 CG1 VAL L 97 26.871 -1.164 9.220 1.00 14.09 ATOM 895 CG2 VAL L 97 27.888 -3.005 7.873 1.00 8.66 ATOM 896 C VALL 97 24.605 -1.151 7.396 1.00 14.93 ATOM 897 0 VAL L 97 24.590 -0.314 6.485 1.00 9.72 ATOM 898 N PHEL 98 23.668 -1.219 8.353 1.00 13.01 ATOM 900 CA PHE L 98 22.630 -0.221 8.460 1.00 12.29 ATOM 901 CB PHEL 98 21.310 -0.843 8.887 1.00 9.91 ATOM 902 CG PHEL 98 20.504 -1.468 7.803 1.00 7.44 ATOM 903 CD1 PHEL 98 20.808 -2.728 7.341 1.00 9.14 ATOM 904 CD2 PHE L 98 19.386 -0.836 7.316 1.00 6.37 ATOM 905 CE1 PHE L 98 20.000 -3.337 6.425 1.00 6.90 ATOM 906 CE2 PHE L 98 18.560 -1.438 6.388 1.00 8.01 ATOM 907 CZ PHEL 98 18.866 -2.696 5.939 1.00 7.78 ATOM 908 C PHEL 98 23.038 0.846 9.456 1.00 11.91 ATOM 909 O PHEL 98 23.874 0.594 10.318 1.00 11.43 ATOM 910 N GLY L 99 22.533 2.062 9.247 1.00 14.08 ATOM 912 CA GLYL 99 22.804 3.151 10.148 1.00 12.11 ATOM 913 C GLYL 99 21.820 3.098 11.296 1.00 11.79 ATOM 914 O GLYL 99 20.893 2.304 11.265 1.00 10.46 ATOM 915 N GLYL 100 22.005 3.957 12.289 1.00 12.00 ATOM 917 CA GLY L 100 21.125 3.950 13.458 1.00 8.79 ATOM 918 C GLYL 100 19.739 4.511 13.254 1.00 9.23 ATOM 919 O GLYL 100 18.840 4.293 14.098 1.00 12.86 ATOM 920 N GLYL 101 19.513 5.213 12.163 1.00 7.60 ATOM 922 CA GLYL 101 18.185 5.779 11.930 1.00 4.00 ATOM 923 C GLYL 101 18.156 7.209 12.445 1.00 7.52 ATOM 924 O GLYL 101 18.921 7.549 13.417 1.00 7.76 ATOM 925 N THRL 102 17.414 8.053 11.698 1.00 8.12 ATOM 927 CA THRL 102 17.192 9.492 12.014 1.00 7.96 ATOM 928 CB THRL 102 17.613 10.425 10.805 1.00 7.52 ATOM 929 OG1 THRL 102 19.020 10.319 10.576 1.00 4.45 ATOM 931 CG2THRL 102 17.266 11.885 11.056 1.00 4.44 ATOM 932 C THRL 102 15.707 9.657 12.212 1.00 10.01 ATOM 933 O THRL 102 14.965 9.257 11.330 1.00 11.13 ATOM 934 N LYSL 103 15.221 10.188 13.349 1.00 10.41 ATOM 936 CA LYSL 103 13.779 10.404 13.436 1.00 11.36 ATOM 937 CB LYSL 103 13.226 10.449 14.887 1.00 14.52 ATOM 938 CG LYS L 103 11.770 11.006 14.917 1.00 16.54 ATOM 939 CD LYSL 103 11.191 11.143 16.337 1.00 12.70 ATOM 940 CE LYS L 103 9.718 11.536 16.299 1.00 14.64 ATOM 941 NZ LYS L 103 8.869 10.602 15.451 1.00 17.17 ATOM 945 C LYS L 103 13.446 11.719 12.778 1.00 10.60 ATOM 946 O LYS L 103 14.022 12.721 13.143 1.00 12.19 ATOM 947 N LEU L 104 12.508 11.730 11.847 1.00 9.69 ATOM 949 CA LEUL 104 12.168 12.978 11.228 1.00 11.35 ATOM 950 CB LEU L 104 12.128 12.887 9.693 1.00 9.61 ATOM 951 CG LEUL 104 11.734 14.219 9.032 1.00 10.81 ATOM 952 CD1 LEU L 104 12.879 15.223 9.204 1.00 2.00 ATOM 953 CD2 LEUL 104 11.370 13.998 7.591 1.00 10.86 ATOM 954 C LEUL 104 10.849 13.494 11.718 1.00 10.04 ATOM 955 O LEUL 104 9.857 12.786 11.669 1.00 16.01 ATOM 956 N THRL 105 10.832 14.730 12.221 1.00 11.71 ATOM 958 CA THRL 105 9.581 15.367 12.551 1.00 7.07 ATOM 959 CB THRL 105 9.634 16.082 13.932 1.00 9.46 ATOM 960 OGI THRL 105 9.752 15.104 14.961 1.00 12.27 ATOM 962 CG2THRL 105 8.383 16.936 14.168 1.00 2.15 ATOM 963 C THRL 105 9.232 16.415 11.493 1.00 7.56 ATOM 964 O THRL 105 10.043 17.245 11.158 1.00 9.71 WO 99/10379 PCT/GB98/02542 -173 ATOM 965 N VAL L 106 8.045 16.320 10.958 1.00 9.73 ATOM 967 CA VAL L 106 7.502 17.366 10.095 1.00 11.58 ATOM 968 CB VAL L 106 7.077 16.862 8.710 1.00 9.06 ATOM 969 CGI VALL 106 6.497 18.013 7.899 1.00 6.52 ATOM 970 CG2 VAL L 106 8.310 16.244 8.006 1.00 10.40 ATOM 971 C VALL 106 6.301 17.925 10.847 1.00 11.09 ATOM 972 0 VAL L 106 5.207 17.320 10.868 1.00 13.54 ATOM 973 N LEUL 106A 6.577 19.053 11.520 1.00 12.43 ATOM 975 CA LEUL 106A 5.642 19.701 12.379 1.00 12.13 ATOM 976 CB LEU L 106A 6.113 21.124 12.661 1.00 9.12 ATOM 977 CG LEU L 106A 7.487 21.216 13.339 1.00 7.72 ATOM 978 CD1 LEU L 106A 7.977 22.640 13.275 1.00 9.05 ATOM 979 CD2 LEU L 106A 7.425 20.710 14.802 1.00 6.98 ATOM 980 C LEUL 106A 4.312 19.671 11.757 1.00 13.07 ATOM 981 O LEU L 106A 4.079 20.351 10.783 1.00 18.75 ATOM 982 N GLY L 107 3.459 18.809 12.289 1.00 14.91 ATOM 984 CA GLYL 107 2.110 18.678 11.759 1.00 16.40 ATOM 985 C GLYL 107 1.061 19.131 12.754 1.00 15.29 ATOM 986 O GLYL 107 -0.116 18.916 12.541 1.00 16.64 ATOM 987 N SERL 108 1.523 19.749 13.846 1.00 18.60 ATOM 989 CA SERL 108 0.654 20.252 14.900 1.00 18.91 ATOM 990 CB SERL 108 0.113 19.115 15.777 1.0021.02 ATOM 991 OG SERL 108 1.150 18.546 16.571 1.0027.15 ATOM 993 C SERL 108 1.466 21.163 15.756 1.00 17.58 ATOM 994 O SERL 108 2.689 21.205 15.631 1.00 17.99 ATOM 995 N GLUL 109 0.796 21.813 16.676 1.00 17.83 ATOM 997 CA GLUL 109 1.428 22.764 17.513 1.00 16.58 ATOM 998 CB GLUL 109 0.331 23.558 18.218 1.0021.42 ATOM 999 CG GLU L 109 -0.493 24.469 17.312 1.0026.54 ATOM 1000 CD GLU L 109 -1.293 23.737 16.238 0.50 27.76 ATOM 1001 OE1 GLU L 109 -1.724 22.605 16.512 0.50 28.73 ATOM 1002 OE2GLUL 109 -1.495 24.302 15.113 0.5026.82 ATOM 1003 C GLU L 109 2.297 22.034 18.519 1.00 17.20 ATOM 1004 O GLU L 109 1.920 20.963 18.969 1.00 14.41 ATOM 1005 N LYSL 110 3.437 22.590 18.885 1.00 16.72 ATOM 1007 CA LYS L 110 4.265 21.907 19.855 1.00 20.99 ATOM 1008 CB LYS L 110 5.610 22.576 20.013 1.00 22.20 ATOM 1009 CG LYS L 110 6.485 22.357 18.796 1.00 24.75 ATOM 1010 CD LYSL 110 7.790 23.103 18.889 1.0025.15 ATOM 1011 CE LYS L 110 8.528 23.039 17.563 1.00 30.78 ATOM 1012 NZ LYSL 110 9.928 23.555 17.661 1.0032.12 ATOM 1016 C LYSL 110 3.557 21.790 21.192 1.0021.68 ATOM 1017 O LYSL 110 2.753 22.651 21.562 1.0022.35 ATOM 1018 N SERL 111 3.836 20.687 21.879 1.00 22.71 ATOM 1020 CA SERL 111 3.205 20.372 23.162 1.0021.05 ATOM 1021 CB SERL 111 2.148 19.308 22.923 1.0022.18 ATOM 1022 OG SERL 111 1.301 19.149 24.046 1.00 23.73 ATOM 1024 C SERL 111 4.276 19.861 24.147 1.0021.55 ATOM 1025 O SERL 111 5.085 18.989 23.799 1.00 21.72 ATOM 1026 N SERL 112 4.347 20.473 25.339 1.00 19.80 ATOM 1028 CA SERL 112 5.317 20.077 26.346 1.00 17.43 ATOM 1029 CB SERL 112 5.389 21.174 27.397 1.00 20.85 ATOM 1030 OG SERL 112 6.341 22.165 27.033 1.0029.98 ATOM 1032 C SERL 112 4.918 18.749 26.998 1.00 14.25 ATOM 1033 O SERL 112 3.726 18.427 27.069 1.00 19.12 ATOM 1034 N PRO L 113 5.860 17.946 27.492 1.00 10.92 ATOM 1035 CD PROL 113 7.314 18.159 27.548 1.00 7.81 ATOM 1036 CA PROL 113 5.491 16.696 28.117 1.00 12.79 ATOM 1037 CB PROL 113 6.794 15.982 28.227 1.00 8.93 ATOM 1038 CG PRO L 113 7.734 17.088 28.499 1.00 9.20 ATOM 1039 C PRO L 113 4.824 16.896 29.483 1.00 13.59 ATOM 1040 O PROL 113 5.181 17.799 30.251 1.00 13.35 ATOM 1041 N SERL 114 3.810 16.116 29.741 1.00 15.55 ATOM 1043 CA SERL 114 3.233 16.066 31.058 1.00 15.08 ATOM 1044 CB SERL 114 1.734 15.863 30.975 1.00 17.33 ATOM 1045 OG SERL 114 1.142 15.947 32.273 1.00 25.09 ATOM 1047 C SERL 114 3.904 14.922 31.825 1.00 16.29 ATOM 1048 O SERL 114 3.795 13.732 31.458 1.00 15.53 ATOM 1049 N VALL 115 4.628 15.301 32.864 1.00 12.98 ATOM 1051 CA VAL L 115 5.425 14.374 33.668 1.00 12.33 ATOM 1052 CB VALL 115 6.750 15.005 33.997 1.00 6.39 ATOM 1053 CG1 VALL 115 7.689 13.957 34.586 1.00 3.44 WO 99/10379 PCT/GB98/02542 -174 ATOM 1054 CG2 VAL L 115 7.329 15.649 32.742 1.00 9.96 ATOM 1055 C VAL L 115 4.770 13.999 35.000 1.00 13.58 ATOM 1056 0 VAL L 115 4.200 14.837 35.678 1.00 13.43 ATOM 1057 N THRL 116 4.877 12.751 35.360 1.00 12.99 ATOM 1059 CA THRL 116 4.395 12.291 36.646 1.00 11.92 ATOM 1060 CB THRL 116 3.063 11.544 36.555 1.00 10.15 ATOM 1061 OGITHRL 116 2.131 12.353 35.844 1.00 5.53 ATOM 1063 CG2THRL 116 2.518 11.242 37.963 1.00 10.07 ATOM 1064 C THRL116 5.424 11.339 37.206 1.00 13.44 ATOM 1065 O THRL 116 5.890 10.420 36.477 1.00 13.00 ATOM 1066 N LEU L 117 5.817 11.574 38.463 1.00 9.86 ATOM 1068 CA LEUL 117 6.772 10.697 39.109 1.00 10.48 ATOM 1069 CB LEUL 117 7.979 11.494 39.504 1.00 8.99 ATOM 1070 CG LEUL 117 9.092 10.708 40.182 1.00 13.84 ATOM 1071 CD1 LEU L 117 9.754 9.741 39.203 1.00 10.30 ATOM 1072 CD2LEUL 117 10.103 11.683 40.772 1.00 17.17 ATOM 1073 C LEUL 117 6.129 9.969 40.328 1.00 9.98 ATOM 1074 O LEUL 117 5.449 10.575 41.149 1.00 12.16 ATOM 1075 N PHEL 118 6.314 8.676 40.398 1.00 9.99 ATOM 1077 CA PHEL 118 5.728 7.871 41.449 1.00 9.51 ATOM 1078 CB PHEL 118 4.868 6.756 40.872 1.00 6.53 ATOM 1079 CG PHEL 118 3.648 7.209 40.167 1.00 6.03 ATOM 1080 CDI PHEL 118 2.533 7.617 40.889 1.00 4.85 ATOM 1081 CD2PHEL 118 3.574 7.148 38.760 1.00 3.25 ATOM 1082 CEl PHEL 118 1.345 7.947 40.244 1.00 6.00 ATOM 1083 CE2PHEL 118 2.398 7.484 38.118 1.00 2.00 ATOM 1084 CZ PHEL 118 1.272 7.881 38.861 1.00 3.81 ATOM 1085 C PHEL 118 6.816 7.225 42.272 1.00 9.33 ATOM 1086 O PHEL 118 7.836 6.726 41.745 1.00 9.88 ATOM 1087 N PROL 119 6.624 7.227 43.591 1.00 9.00 ATOM 1088 CD PROL 119 5.458 7.837 44.283 1.00 7.59 ATOM 1089 CA PROL 119 7.582 6.622 44.541 1.00 8.55 ATOM 1090 CB PROL 119 7.173 7.283 45.851 1.00 9.62 ATOM 1091 CG PROL 119 5.685 7.380 45.703 1.00 9.04 ATOM 1092 C PROL 119 7.379 5.121 44.603 1.00 4.72 ATOM 1093 O PROL 119 6.383 4.647 44.105 1.00 6.50 ATOM 1094 N PROL 120 8.311 4.363 45.159 1.00 3.79 ATOM 1095 CD PRO L 120 9.661 4.784 45.473 1.00 6.28 ATOM 1096 CA PRO L 120 8.158 2.910 45.301 1.00 6.76 ATOM 1097 CB PRO L 120 9.507 2.416 45.767 1.00 9.39 ATOM 1098 CG PRO L 120 10.194 3.621 46.269 1.00 5.45 ATOM 1099 C PRO L 120 7.032 2.552 46.267 1.00 10.87 ATOM 1100 O PRO L 120 6.788 3.263 47.246 1.00 11.35 ATOM 1101 N SERL 121 6.276 1.518 45.944 1.00 12.02 ATOM 1103 CA SER L 121 5.172 1.105 46.811 1.00 14.15 ATOM 1104 CB SERL 121 4.160 0.187 46.055 1.00 13.52 ATOM 1105 OG SERL 121 4.706 -1.083 45.758 1.00 14.31 ATOM 1107 C SERL 121 5.737 0.415 48.061 1.00 15.89 ATOM 1108 O SERL 121 6.916 0.005 48.087 1.00 14.68 ATOM 1109 N SERL 122 4.923 0.342 49.116 1.00 15.71 ATOM 1111 CA SER L 122 5.363 -0.308 50.339 1.00 17.27 ATOM 1112 CB SERL 122 4.334 -0.057 51.448 1.00 17.69 ATOM 1113 OG SERL 122 3.023 -0.391 51.004 1.00 25.59 ATOM 1115 C SERL 122 5.512 -1.801 50.069 1.00 14.07 ATOM 1116 O SERL 122 6.481 -2.426 50.529 1.00 16.14 ATOM 1117 N ALA L 123 4.559 -2.338 49.272 1.00 11.63 ATOM 1119 CA ALAL 123 4.558 -3.769 48.934 1.00 10.10 ATOM 1120 CB ALA L 123 3.319 -4.106 48.130 1.00 13.01 ATOM 1121 C ALAL 123 5.828 -4.148 48.204 1.00 9.75 ATOM 1122 O ALAL 123 6.478 -5.134 48.560 1.00 6.87 ATOM 1123 N GLU L 124 6.253 -3.321 47.225 1.00 8.37 ATOM 1125 CA GLU L 124 7.493 -3.602 46.545 1.00 7.57 ATOM 1126 CB GLU L 124 7.789 -2.653 45.377 1.00 9.85 ATOM 1127 CG GLUL 124 9.123 -2.992 44.703 1.00 9.19 ATOM 1128 CD GLUL 124 9.466 -2.117 43.521 1.00 8.89 ATOM 1129 OE1 GLU L 124 8.843 -1.079 43.377 1.00 11.65 ATOM 1130 OE2 GLU L 124 10.370 -2.461 42.741 1.00 10.96 ATOM 1131 C GLUL 124 8.653 -3.537 47.482 1.00 8.44 ATOM 1132 O GLU L 124 9.501 -4.435 47.473 1.00 7.83 ATOM 1133 N LEU L 125 8.701 -2.484 48.325 1.00 10.06 ATOM 1135 CA LEU L 125 9.842 -2.287 49.268 1.00 8.99 ATOM 1136 CB LEUL 125 9.576 -1.049 50.147 1.00 6.82 WO 99/10379 PCT/GB98/02542 -175 ATOM 1137 CG LEU L 125 9.871 0.279 49.439 1.00 8.44 ATOM 1138 CDI LEU L 125 9.200 1.466 50.110 1.00 10.23 ATOM 1139 CD2 LEU L 125 11.373 0.475 49.349 1.00 10.82 ATOM 1140 C LEU L 125 10.121 -3.494 50.150 1.00 7.68 ATOM 1141 O LEU L 125 11.288 -3.786 50.519 1.00 6.19 ATOM 1142 N GLU L 126 9.069 -4.188 50.506 1.00 9.15 ATOM 1144 CA GLU L 126 9.227 -5.365 51.341 1.00 12.67 ATOM 1145 CB GLU L 126 7.899 -6.020 51.519 1.00 15.98 ATOM 1146 CG GLUL 126 6.888 -5.137 52.171 1.00 19.89 ATOM 1147 CD GLU L 126 5.648 -5.907 52.484 1.00 22.91 ATOM 1148 OEI GLU L 126 5.696 -7.174 52.467 1.00 24.59 ATOM 1149 OE2 GLU L 126 4.612 -5.254 52.744 1.00 26.87 ATOM 1150 C GLU L 126 10.169 -6.368 50.702 1.00 14.63 ATOM 1151 O GLU L 126 10.842 -7.132 51.421 1.00 12.25 ATOM 1152 N THR L 127 10.179 -6.388 49.326 1.00 13.98 ATOM 1154 CA THRL 127 11.054 -7.312 48.549 1.00 13.13 ATOM 1155 CB THR L 127 10.542 -7.570 47.086 1.00 11.80 ATOM 1156 OGI THRL 127 10.753 -6.412 46.267 1.00 10.21 ATOM 1158 CG2THRL 127 9.068 -7.926 47.066 1.00 12.12 ATOM 1159 C THR L 127 12.460 -6.775 48.453 1.00 12.72 ATOM 1160 O THRL 127 13.266 -7.316 47.715 1.00 14.85 ATOM 1161 N ASN L 128 12.740 -5.706 49.208 1.00 13.49 ATOM 1163 CA ASN L 128 14.045 -5.057 49.225 1.00 13.82 ATOM 1164 CB ASNL 128 15.145 -6.048 49.663 1.00 19.63 ATOM 1165 CG ASN L 128 15.125 -6.270 51.168 1.0023.79 ATOM 1166 OD1 ASNL 128 14.932 -7.391 51.638 1.00 26.72 ATOM 1167 ND2ASNL 128 15.314 -5.191 51.937 1.0025.77 ATOM 1170 C ASNL 128 14.399 -4.369 47.910 1.00 14.19 ATOM 1171 O ASNL 128 15.595 -4.130 47.597 1.00 13.24 ATOM 1172 N LYS L 129 13.354 -4.000 47.173 1.00 17.87 ATOM 1174 CA LYSL 129 13.501 -3.318 45.900 1.00 18.00 ATOM 1175 CB LYS L 129 13.046 -4.229 44.745 1.00 22.35 ATOM 1176 CG LYS L 129 13.716 -5.598 44.695 1.00 24.95 ATOM 1177 CD LYS L 129 15.206 -5.464 44.537 1.00 28.22 ATOM 1178 CE LYS L 129 15.848 -6.815 44.346 1.00 30.22 ATOM 1179 NZ LYS L 129 15.385 -7.425 43.073 1.00 34.30 ATOM 1183 C LYS L 129 12.666 -2.037 45.876 1.00 16.78 ATOM 1184 O LYSL 129 11.603 -1.956 46.464 1.00 15.40 ATOM 1185 N ALAL 130 13.165 -1.045 45.172 1.00 16.40 ATOM 1187 CA ALA L 130 12.452 0.224 45.009 1.00 15.30 ATOM 1188 CB ALAL 130 12.995 1.278 45.962 1.00 10.48 ATOM 1189 C ALAL 130 12.575 0.729 43.554 1.00 13.30 ATOM 1190 O ALA L 130 13.692 0.976 43.062 1.00 13.88 ATOM 1191 N THRL 131 11.420 0.825 42.873 1.00 10.24 ATOM 1193 CA THRL 131 11.369 1.338 41.527 1.00 8.65 ATOM 1194 CB THRL 131 10.689 0.363 40.539 1.00 9.65 ATOM 1195 OG1 THRL 131 11.282 -0.953 40.646 1.00 10.61 ATOM 1197 CG2THRL 131 10.801 0.902 39.092 1.00 8.13 ATOM 1198 C THRL 131 10.568 2.603 41.513 1.00 4.73 ATOM 1199 O THRL 131 9.464 2.621 42.019 1.00 7.42 ATOM 1200 N LEUL 132 11.149 3.647 40.968 1.00 5.79 ATOM 1202 CA LEU L 132 10.449 4.904 40.787 1.00 8.20 ATOM 1203 CB LEU L 132 11.386 6.086 41.075 1.00 7.00 ATOM 1204 CG LEUL 132 11.799 6.378 42.544 1.00 9.11 ATOM 1205 CD1 LEU L 132 12.650 5.258 43.104 1.00 6.00 ATOM 1206 CD2 LEU L 132 12.609 7.678 42.596 1.00 8.20 ATOM 1207 C LEU L 132 9.976 4.970 39.341 1.00 7.07 ATOM 1208 O LEU L 132 10.743 4.665 38.440 1.00 10.93 ATOM 1209 N VALL 133 8.742 5.331 39.116 1.00 7.44 ATOM 1211 CA VALL 133 8.234 5.363 37.756 1.00 7.69 ATOM 1212 CB VALL 133 6.923 4.598 37.629 1.00 5.71 ATOM 1213 CGI VALL 133 6.392 4.690 36.194 1.00 5.28 ATOM 1214 CG2 VALL 133 7.145 3.138 38.022 1.00 10.59 ATOM 1215 C VALL 133 7.970 6.779 37.300 1.00 8.68 ATOM 1216 0 VALL 133 7.296 7.541 37.962 1.00 8.54 ATOM 1217 N CYSL 134 8.448 7.117 36.140 1.00 12.17 ATOM 1219 CA CYS L 134 8.204 8.457 35.595 1.00 9.67 ATOM 1220 CB CYSL 134 9.558 9.120 35.346 1.00 8.40 ATOM 1221 SG CYS L 134 9.463 10.812 34.680 1.00 10.83 ATOM 1222 C CYS L 134 7.451 8.308 34.295 1.00 9.67 ATOM 1223 O CYS L 134 8.004 7.706 33.371 1.00 10.89 ATOM 1224 N THRL 135 6.195 8.745 34.238 1.00 6.29 WO 99/10379 PCT/GB98/02542 -176 ATOM 1226 CA THRL 135 5.469 8.655 33.028 1.00 5.35 ATOM 1227 CB .THRL 135 4.012 8.195 33.246 1.00 5.71 ATOM 1228 OGI THRL 135 3.231 9.219 33.891 1.00 11.96 ATOM 1230 CG2THRL 135 3.984 6.920 34.095 1.00 2.00 ATOM 1231 C THRL 135 5.547 9.987 32.316 1.00 9.71 ATOM 1232 O THRL 135 5.826 11.012 32.949 1.00 11.41 ATOM 1233 N ILEL 136 5.426 9.983 30.994 1.00 9.98 ATOM 1235 CA ILEL 136 5.672 11.228 30.205 1.00 11.09 ATOM 1236 CB ILEL 136 7.150 11.268 29.663 1.00 12.20 ATOM 1237 CG2 ILE L 136 7.420 12.602 28.960 1.00 10.90 ATOM 1238 CG1 ILE L 136 8.166 11.011 30.783 1.00 10.97 ATOM 1239 CD ILEL 136 9.578 10.697 30.284 1.00 11.49 ATOM 1240 C ILEL 136 4.723 11.215 29.019 1.00 10.64 ATOM 1241 O ILEL 136 4.806 10.326 28.215 1.00 11.08 ATOM 1242 N THRL 137 3.795 12.154 28.927 1.00 10.77 ATOM 1244 CA THRL 137 2.811 12.071 27.890 1.00 9.97 ATOM 1245 CB THR L 137 1.469 11.499 28.449 1.00 11.90 ATOM 1246 OGI THRL 137 0.866 12.381 29.434 1.00 11.66 ATOM 1248 CG2THRL 137 1.724 10.164 29.119 1.00 12.72 ATOM 1249 C THRL 137 2.596 13.417 27.221 1.00 13.30 ATOM 1250 O THRL 137 3.181 14.431 27.670 1.00 10.45 ATOM 1251 N ASPL 138 1.825 13.363 26.116 1.00 12.35 ATOM 1253 CA ASP L 138 1.342 14.541 25.354 1.00 14.23 ATOM 1254 CB ASP L 138 0.325 15.323 26.180 1.00 12.77 ATOM 1255 CG ASP L 138 -0.778 14.452 26.713 1.00 16.64 ATOM 1256 ODI ASPL 138 -1.699 14.084 25.926 1.00 15.94 ATOM 1257 OD2 ASP L 138 -0.734 14.127 27.929 1.00 16.10 ATOM 1258 C ASP L 138 2.407 15.499 24.869 1.00 12.96 ATOM 1259 O ASPL 138 2.181 16.698 24.879 1.00 13.42 ATOM 1260 N PHE L 139 3.568 15.004 24.439 1.00 15.33 ATOM 1262 CA PHE L 139 4.590 15.914 23.899 1.00 12.61 ATOM 1263 CB PHE L 139 5.988 15.685 24.488 1.00 13.93 ATOM 1264 CG PHEL 139 6.452 14.249 24.550 1.00 17.51 ATOM 1265 CDI PHE L 139 6.016 13.407 25.571 1.00 14.06 ATOM 1266 CD2 PHE L 139 7.344 13.747 23.599 1.00 18.44 ATOM 1267 CE1 PHEL 139 6.450 12.114 25.644 1.00 15.91 ATOM 1268 CE2 PHE L 139 7.781 12.440 23.674 1.00 17.97 ATOM 1269 CZ PHEL 139 7.331 11.616 24.701 1.00 19.08 ATOM 1270 C PHE L 139 4.671 15.822 22.398 1.00 14.58 ATOM 1271 O PHEL 139 4.364 14.779 21.822 1.00 13.97 ATOM 1272 N TYRL 140 5.003 16.967 21.771 1.00 14.53 ATOM 1274 CA TYRL 140 5.221 17.043 20.317 1.00 15.96 ATOM 1275 CB TYRL 140 3.934 17.281 19.554 1.00 9.65 ATOM 1276 CG TYRL 140 4.165 17.225 18.059 1.00 17.09 ATOM 1277 CDI TYRL 140 4.137 16.015 17.390 1.00 18.26 ATOM 1278 CE1 TYRL 140 4.377 15.939 16.022 1.00 18.78 ATOM 1279 CD2TYRL 140 4.445 18.376 17.314 1.00 17.33 ATOM 1280 CE2TYRL 140 4.691 18.309 15.948 1.00 17.98 ATOM 1281 CZ TYRL 140 4.650 17.083 15.318 1.00 19.92 ATOM 1282 OH TYRL 140 4.861 17.000 13.970 1.0021.97 ATOM 1284 C TYRL 140 6.157 18.195 20.052 1.00 14.90 ATOM 1285 O TYRL 140 5.831 19.286 20.462 1.00 17.79 ATOM 1286 N PRO L 141 7.343 18.014 19.373 1.00 17.44 ATOM 1287 CD PRO L 141 8.353 19.083 19.188 1.00 18.49 ATOM 1288 CA PRO L 141 7.859 16.742 18.793 1.00 16.51 ATOM 1289 CB PRO L 141 9.251 17.124 18.303 1.00 16.41 ATOM 1290 CG PRO L 141 9.134 18.569 18.033 1.00 18.35 ATOM 1291 C PRO L 141 7.977 15.581 19.781 1.00 17.49 ATOM 1292 O PRO L 141 8.147 15.784 21.000 1.00 16.25 ATOM 1293 N GLY L 142 7.918 14.379 19.234 1.00 16.47 ATOM 1295 CA GLY L 142 8.090 13.192 20.037 1.00 17.96 ATOM 1296 C GLY L 142 9.530 12.886 20.377 1.00 17.11 ATOM 1297 O GLY L 142 9.975 11.757 20.259 1.00 20.37 ATOM 1298 N VAL L 143 10.292 13.854 20.777 1.00 17.91 ATOM 1300 CA VALL 143 11.632 13.552 21.210 1.0020.37 ATOM 1301 CB VALL 143 12.695 13.972 20.179 1.00 25.23 ATOM 1302 CGI VAL L 143 12.502 15.421 19.764 1.00 27.03 ATOM 1303 CG2 VAL L 143 14.083 13.765 20.778 1.00 23.81 ATOM 1304 C VAL L 143 11.921 14.205 22.557 1.00 20.36 ATOM 1305 0 VALL 143 11.713 15.416 22.712 1.00 18.56 ATOM 1306 N VALL 144 12.396 13.381 23.522 1.00 18.00 ATOM 1308 CA VAL L 144 12.718 13.845 24.891 1.00 18.09 WO 99/10379 PCT/GB98/02542 -177 ATOM 1309 CB VALL 144 11.582 13.532 25.913 1.00 15.31 ATOM 1310 CGI VAL L 144 10.334 14.306 25.602 1.00 13.05 ATOM 1311 CG2VALL 144 11.282 12.036 25.925 1.00 15.08 ATOM 1312 C VALL 144 13.941 13.125 25.397 1.00 17.23 ATOM 1313 OVALL 144 14.189 11.991 24.992 1.00 15.86 ATOM 1314 N THRL 145 14.744 13.798 26.217 1.00 16.98 ATOM 1316 CA THRL 145 15.795 13.107 26.924 1.00 17.36 ATOM 1317 CB THRL 145 17.233 13.739 26.775 1.00 22.21 ATOM 1318 OG1 THRL 145 17.569 14.568 27.897 1.00 22.36 ATOM 1320 CG2 THR L 145 17.366 14.530 25.486 1.00 19.06 ATOM 1321 C THRL 145 15.378 13.091 28.392 1.00 19.55 ATOM 1322 O THRL 145 14.813 14.077 28.871 1.00 15.45 ATOM 1323 N VAL L 146 15.578 11.946 29.064 1.00 19.67 ATOM 1325 CA VAL L 146 15.185 11.787 30.463 1.00 17.75 ATOM 1326 CB VAL L 146 14.353 10.502 30.668 1.00 15.39 ATOM 1327 CG1 VAL L 146 14.100 10.249 32.158 1.00 16.28 ATOM 1328 CG2 VAL L 146 13.051 10.633 29.945 1.00 12.45 ATOM 1329 C VALL 146 16.429 11.709 31.327 1.00 18.57 ATOM 1330 O VALL 146 17.354 10.986 31.018 1.0020.82 ATOM 1331 N ASPL 147 16.442 12.464 32.396 1.00 16.64 ATOM 1333 CA ASP L 147 17.574 12.502 33.271 1.00 16.87 ATOM 1334 CB ASP L 147 18.284 13.862 33.104 1.0022.38 ATOM 1335 CG ASPL 147 19.067 13.963 31.791 1.0025.15 ATOM 1336 ODIASPL 147 20.153 13.344 31.712 1.0025.53 ATOM 1337 OD2 ASP L 147 18.586 14.651 30.843 1.00 24.06 ATOM 1338 C ASP L 147 17.104 12.315 34.710 1.00 13.63 ATOM 1339 O ASPL 147 16.220 13.032 35.167 1.00 17.40 ATOM 1340 N TRP L 148 17.676 11.358 35.399 1.00 12.32 ATOM 1342 CA TRP L 148 17.287 11.061 36.792 1.00 8.34 ATOM 1343 CB TRP L 148 17.209 9.521 36.985 1.00 7.75 ATOM 1344 CG TRP L 148 16.010 8.879 36.377 1.00 9.41 ATOM 1345 CD2 TRP L 148 14.738 8.705 37.013 1.00 7.75 ATOM 1346 CE2 TRP L 148 13.895 8.079 36.088 1.00 9.98 ATOM 1347 CE3TRPL 148 14.241 9.019 38.304 1.00 11.38 ATOM 1348 CD1 TRPL 148 15.889 8.362 35.116 1.00 5.30 ATOM 1349 NE1 TRP L 148 14.627 7.895 34.964 1.00 10.25 ATOM 1351 CZ2 TRP L 148 12.576 7.750 36.379 1.00 10.62 ATOM 1352 CZ3 TRP L 148 12.929 8.690 38.606 1.00 8.84 ATOM 1353 CH2TRPL 148 12.106 8.061 37.642 1.00 9.81 ATOM 1354 C TRPL 148 18.328 11.611 37.741 1.00 10.55 ATOM 1355 O TRPL 148 19.526 11.572 37.440 1.00 11.66 ATOM 1356 N LYSL 149 17.904 12.113 38.891 1.00 10.12 ATOM 1358 CA LYS L 149 18.858 12.592 39.860 1.00 10.24 ATOM 1359 CB LYS L 149 18.985 14.121 39.739 1.00 9.85 ATOM 1360 CG LYS L 149 19.879 14.486 38.551 1.00 15.84 ATOM 1361 CD LYS L 149 19.786 15.934 38.146 1.0020.45 ATOM 1362 CE LYS L 149 20.968 16.327 37.251 1.0025.03 ATOM 1363 NZ LYS L 149 21.280 15.297 36.192 1.0026.83 ATOM 1367 C LYS L 149 18.508 12.120 41.265 1.00 9.83 ATOM 1368 O LYS L 149 17.341 11.959 41.593 1.00 8.42 ATOM 1369 N VAL L 150 19.554 11.804 42.034 1.00 12.70 ATOM 1371 CA VALL 150 19.402 11.385 43.438 1.00 13.13 ATOM 1372 CB VAL L 150 19.928 9.952 43.602 1.00 14.08 ATOM 1373 CG1 VAL L 150 20.396 9.706 45.001 1.00 9.65 ATOM 1374 CG2 VAL L 150 18.814 8.969 43.242 1.00 12.12 ATOM 1375 C VALL 150 20.157 12.351 44.369 1.00 13.82 ATOM 1376 0 VALL 150 21.401 12.411 44.353 1.00 11.33 ATOM 1377 N ASP L 151 19.404 13.120 45.185 1.00 15.72 ATOM 1379 CA ASPL 151 20.015 14.144 46.055 1.00 13.64 ATOM 1380 CB ASP L 151 20.890 13.514 47.148 1.00 17.87 ATOM 1381 CG ASPL 151 20.098 12.911 48.300 1.0018.72 ATOM 1382 ODI ASP L 151 18.864 13.024 48.312 1.00 17.99 ATOM 1383 OD2ASPL 151 20.716 12.318 49.203 1.0020.12 ATOM 1384 C ASP L 151 20.831 15.094 45.207 1.00 12.12 ATOM 1385 O ASPL 151 21.950 15.539 45.548 1.00 14.72 ATOM 1386 N GLY L 152 20.291 15.366 44.072 1.00 13.53 ATOM 1388 CA GLY L 152 20.915 16.310 43.184 1.00 15.70 ATOM 1389 C GLY L 152 21.962 15.737 42.261 1.00 16.31 ATOM 1390 O GLY L 152 22.367 16.417 41.334 1.00 17.83 ATOM 1391 N THRL 153 22.402 14.503 42.469 1.00 18.56 ATOM 1393 CA THRL 153 23.470 13.953 41.618 1.00 18.43 ATOM 1394 CB THRL 153 24.506 13.187 42.455 1.00 19.60 WO 99/10379 PCT/GB98/02542 -178 ATOM 1395 OGI THRL 153 23.922 11.995 42.976 1.00 25.85 ATOM 1397 CG2 THR L 153 24.950 14.035 43.642 1.00 23.47 ATOM 1398 C THRL 153 22.898 13.092 40.464 1.00 18.68 ATOM 1399 O THRL 153 21.884 12.405 40.595 1.00 18.23 ATOM 1400 N PRO L 154 23.513 13.163 39.280 1.00 18.73 ATOM 1401 CD PRO L 154 24.731 13.947 38.974 1.00 19.95 ATOM 1402 CA PRO L 154 23.033 12.415 38.103 1.00 18.94 ATOM 1403 CB PRO L 154 23.849 13.028 36.966 1.00 18.59 ATOM 1404 CG PRO L 154 25.139 13.351 37.660 1.00 18.89 ATOM 1405 C PRO L 154 23.197 10.907 38.242 1.00 15.33 ATOM 1406 O PROL 154 24.228 10.437 38.673 1.00 16.30 ATOM 1407 N VAL L 155 22.154 10.137 37.959 1.00 16.59 ATOM 1409 CA VAL L 155 22.332 8.695 38.029 1.00 19.40 ATOM 1410 CB VAL L 155 21.085 7.954 38.622 1.00 19.34 ATOM 1411 CGI VAL L 155 20.152 8.939 39.284 1.00 18.37 ATOM 1412 CG2 VAL L 155 20.364 7.120 37.576 1.00 18.74 ATOM 1413 C VAL L 155 22.758 8.134 36.630 1.00 21.02 ATOM 1414 0 VAL L 155 22.403 8.683 35.565 1.00 19.02 ATOM 1415 N THRL 156 23.590 7.103 36.649 1.0022.42 ATOM 1417 CA THRL 156 24.084 6.518 35.421 1.0023.32 ATOM 1418 CB THRL 156 25.572 6.776 35.297 1.00 23.16 ATOM 1419 OGI THRL 156 26.227 6.308 36.480 1.00 25.01 ATOM 1421 CG2THRL 156 25.825 8.259 35.140 1.00 25.87 ATOM 1422 C THRL 156 23.868 5.030 35.422 1.00 25.17 ATOM 1423 O THRL 156 24.366 4.330 34.557 1.00 28.73 ATOM 1424 N GLNL 157 23.119 4.542 36.379 1.0023.46 ATOM 1426 CA GLNL 157 22.911 3.142 36.481 1.0023.50 ATOM 1427 CB GLNL 157 23.955 2.603 37.417 1.0029.55 ATOM 1428 CG GLN L 157 24.082 1.104 37.377 1.00 37.55 ATOM 1429 CD GLNL 157 25.314 0.646 38.117 1.0043.33 ATOM 1430 OE1 GLNL 157 25.777 1.317 39.059 1.0043.65 ATOM 1431 NE2GLNL 157 25.865 -0.493 37.685 1.00 45.54 ATOM 1434 C GLN L 157 21.518 2.866 37.002 1.00 19.92 ATOM 1435 O GLNL 157 21.011 3.632 37.773 1.00 18.81 ATOM 1436 N GLY L 158 20.889 1.810 36.538 1.00 18.99 ATOM 1438 CA GLY L 158 19.556 1.472 37.015 1.00 20.19 ATOM 1439 C GLY L 158 18.384 2.250 36.379 1.00 22.36 ATOM 1440 O GLYL 158 17.258 2.080 36.791 1.00 22.31 ATOM 1441 N METL 159 18.624 3.105 35.392 1.0024.81 ATOM 1443 CA METL 159 17.529 3.817 34.750 1.00 22.88 ATOM 1444 CB MET L 159 17.796 5.327 34.682 1.00 23.15 ATOM 1445 CG METL 159 18.824 5.803 33.688 1.0026.34 ATOM 1446 SD MET L 159 20.513 5.742 34.305 1.0034.44 ATOM 1447 CE METL 159 21.012 4.154 33.640 1.0031.53 ATOM 1448 C METL 159 17.266 3.230 33.363 1.0023.01 ATOM 1449 O METL 159 18.173 2.800 32.688 1.00 24.49 ATOM 1450 N GLU L 160 16.020 3.191 32.958 1.00 19.49 ATOM 1452 CA GLUL 160 15.666 2.598 31.715 1.00 19.70 ATOM 1453 CB GLUL 160 15.367 1.118 31.969 1.0021.50 ATOM 1454 CG GLU L 160 14.549 0.400 30.931 1.0024.34 ATOM 1455 CD GLU L 160 15.309 0.068 29.669 1.00 30.12 ATOM 1456 OEI GLU L 160 16.548 -0.128 29.774 1.00 28.32 ATOM 1457 OE2 GLU L 160 14.660 0.005 28.567 1.00 30.69 ATOM 1458 C GLU L 160 14.484 3.332 31.146 1.00 19.64 ATOM 1459 O GLUL 160 13.438 3.390 31.774 1.00 18.31 ATOM 1460 N THR L 161 14.663 3.904 29.945 1.00 20.21 ATOM 1462 CA THRL 161 13.606 4.711 29.285 1.00 18.39 ATOM 1463 CB THRL 161 14.152 6.135 28.966 1.00 19.35 ATOM 1464 OGI THRL 161 14.634 6.725 30.180 1.00 15.43 ATOM 1466 CG2THRL 161 13.085 7.028 28.361 1.00 13.84 ATOM 1467 C THR L 161 13.089 4.048 27.992 1.00 18.90 ATOM 1468 O THRL 161 13.855 3.391 27.282 1.00 18.53 ATOM 1469 N THRL 162 11.776 4.198 27.724 1.00 17.02 ATOM 1471 CA THR L 162 11.162 3.604 26.558 1.00 14.46 ATOM 1472 CB THRL 162 9.771 3.023 26.877 1.00 9.31 ATOM 1473 OGI THR L 162 8.882 4.060 27.343 1.00 8.44 ATOM 1475 CG2 THRL 162 9.890 1.934 27.939 1.00 8.50 ATOM 1476 C THRL 162 11.080 4.614 25.407 1.00 15.09 ATOM 1477 O THRL 162 11.086 5.838 25.608 1.00 14.93 ATOM 1478 N ALAL 163 11.055 4.106 24.190 1.00 12.96 ATOM 1480 CA ALA L 163 11.045 4.973 23.048 1.00 10.76 ATOM 1481 CB ALA L 163 11.436 4.206 21.765 1.00 15.08 WO 99/10379 PCT/GB98/02542 -179 ATOM 1482 C ALAL 163 9.711 5.563 22.914 1.00 8.59 ATOM 1483 O ALA L 163 8.730 4.859 22.998 1.00 11.96 ATOM 1484 N PRO L 164 9.639 6.885 22.727 1.00 11.37 ATOM 1485 CD PRO L 164 10.782 7.823 22.601 1.00 12.89 ATOM 1486 CA PRO L 164 8.372 7.584 22.589 1.00 11.21 ATOM 1487 CB PRO L 164 8.786 8.958 22.082 1.00 11.04 ATOM 1488 CG PROL 164 10.083 9.139 22.783 1.00 11.07 ATOM 1489 C PRO L 164 7.506 6.838 21.620 1.00 12.84 ATOM 1490 O PRO L 164 8.003 6.161 20.722 1.00 17.44 ATOM 1491 N SERL 165 6.241 6.881 21.819 1.00 14.17 ATOM 1493 CA SERL 165 5.355 6.186 20.922 1.00 16.08 ATOM 1494 CB SERL 165 4.917 4.813 21.480 1.00 17.01 ATOM 1495 OG SER L 165 3.832 4.924 22.378 1.00 22.35 ATOM 1497 C SER L 165 4.220 7.095 20.722 1.00 15.78 ATOM 1498 O SERL 165 3.950 7.910 21.590 1.00 15.19 ATOM 1499 N LYS L 166 3.597 7.013 19.588 1.00 17.84 ATOM 1501 CA LYS L 166 2.582 7.984 19.248 1.00 19.88 ATOM 1502 CB LYS L 166 2.391 8.017 17.746 1.00 22.34 ATOM 1503 CG LYS L 166 2.325 9.408 17.139 1.0021.36 ATOM 1504 CD LYSL 166 2.273 9.317 15.606 1.0025.05 ATOM 1505 CE LYS L 166 2.601 10.656 14.965 0.01 22.27 ATOM 1506 NZ LYS L 166 2.538 10.600 13.475 0.01 22.15 ATOM 1510 C LYSL 166 1.282 7.698 19.914 1.0021.48 ATOM 1511 O LYSL 166 0.893 6.541 20.046 1.00 23.82 ATOM 1512 N GLN L 167 0.624 8.768 20.360 1.00 20.46 ATOM 1514 CA GLN L 167 -0.706 8.663 20.929 1.00 19.43 ATOM 1515 CB GLNL 167 -0.959 9.744 21.957 1.00 19.09 ATOM 1516 CG GLNL 167 0.073 9.829 23.070 1.00 13.91 ATOM 1517 CD GLNL 167 -0.173 10.995 24.012 1.00 12.43 ATOM 1518 OE1GLNL 167 0.487 11.132 25.070 1.00 12.78 ATOM 1519 NE2GLNL 167 -1.121 11.854 23.651 1.00 12.35 ATOM 1522 C GLN L 167 -1.691 8.864 19.808 1.0020.58 ATOM 1523 O GLN L 167 -1.337 9.390 18.777 1.00 19.43 ATOM 1524 N SERL 168 -2.917 8.477 20.015 1.0024.20 ATOM 1526 CA SERL 168 -3.932 8.620 18.983 1.0028.22 ATOM 1527 CB SERL 168 -5.283 8.203 19.551 1.0029.04 ATOM 1528 OG SERL 168 -5.480 8.808 20.824 1.0034.62 ATOM 1530 C SERL 168 -4.005 10.061 18.471 1.0030.48 ATOM 1531 O SERL 168 -4.452 10.321 17.331 1.0034.63 ATOM 1532 N ASN L 169 -3.569 11.002 19.285 1.00 26.12 ATOM 1534 CA ASN L 169 -3.650 12.370 18.871 1.00 25.93 ATOM 1535 CB ASNL 169 -4.070 13.284 20.021 1.00 29.63 ATOM 1536 CG ASN L 169 -3.094 13.375 21.169 1.0029.04 ATOM 1537 ODI ASNL 169 -2.067 12.703 21.217 1.00 31.37 ATOM 1538 ND2ASNL 169 -3.431 14.220 22.100 1.00 31.92 ATOM 1541 C ASNL 169 -2.362 12.794 18.299 1.00 25.86 ATOM 1542 O ASN L 169 -2.067 13.967 18.208 1.0026.70 ATOM 1543 N ASN L 170 -1.592 11.830 17.924 1.0023.96 ATOM 1545 CA ASNL 170 -0.328 12.075 17.287 1.00 23.68 ATOM 1546 CB ASNL 170 -0.560 12.714 15.923 1.00 25.27 ATOM 1547 CG ASNL 170 -1.128 11.651 14.991 1.0028.14 ATOM 1548 ODI ASN L 170 -0.430 10.692 14.635 1.00 30.35 ATOM 1549 ND2 ASN L 170 -2.403 11.769 14.642 1.00 29.66 ATOM 1552 C ASNL 170 0.675 12.826 18.113 1.0022.90 ATOM 1553 O ASN L 170 1.705 13.241 17.610 1.0025.60 ATOM 1554 N LYS L 171 0.396 13.038 19.371 1.0021.22 ATOM 1556 CA LYS L 171 1.449 13.518 20.252 1.00 19.04 ATOM 1557 CB LYS L 171 0.892 14.301 21.438 1.00 17.22 ATOM 1558 CG LYSL 171 0.172 15.582 21.119 1.0017.62 ATOM 1559 CD LYSL 171 -0.349 16.198 22.418 1.00 15.11 ATOM 1560 CE LYSL 171 -1.324 17.333 22.147 1.00 18.27 ATOM 1561 NZ LYS L 171 -1.550 18.177 23.353 1.00 14.34 ATOM 1565 C LYS L 171 2.139 12.244 20.757 1.00 17.36 ATOM 1566 O LYSL 171 1.728 11.151 20.397 1.00 17.98 ATOM 1567 N TYRL 172 3.136 12.351 21.587 1.00 14.79 ATOM 1569 CA TYRL 172 3.861 11.169 21.974 1.00 14.85 ATOM 1570 CB TYRL 172 5.296 11.312 21.506 1.00 15.82 ATOM 1571 CG TYRL 172 5.439 11.262 20.008 1.00 17.24 ATOM 1572 CDI TYRL 172 5.187 12.380 19.192 1.00 15.15 ATOM 1573 CEl TYRL 172 5.340 12.297 17.802 1.00 18.45 ATOM 1574 CD2TYRL 172 5.834 10.084 19.402 1.00 17.80 ATOM 1575 CE2TYRL 172 5.986 9.997 18.025 1.0020.12 WO 99/10379 PCT/GB98/02542 -180 ATOM 1576 CZ TYR L 172 5.748 11.093 17.223 1.00 18.23 ATOM 1577 OH TYR L 172 5.957 10.976 15.856 1.00 13.35 ATOM 1579 C TYRL 172 3.841 10.900 23.464 1.00 15.41 ATOM 1580 O TYRL 172 3.602 11.815 24.277 1.00 14.17 ATOM 1581 N METL 173 4.112 9.631 23.818 1.00 13.34 ATOM 1583 CA METL 173 4.194 9.234 25.193 1.00 9.55 ATOM 1584 CB METL 173 2.931 8.486 25.587 1.00 10.24 ATOM 1585 CG MET L 173 2.794 7.099 24.973 1.00 15.16 ATOM 1586 SD METL 173 1.458 6.141 25.711 1.0020.11 ATOM 1587 CE MET L 173 0.057 6.915 24.983 1.00 12.86 ATOM 1588 C MET L 173 5.456 8.378 25.432 1.00 10.38 ATOM 1589 O METL 173 6.004 7.765 24.500 1.00 10.40 ATOM 1590 N ALAL 174 5.930 8.343 26.659 1.00 7.39 ATOM 1592 CA ALA L 174 7.129 7.587 27.004 1.00 7.66 ATOM 1593 CB ALA L 174 8.390 8.338 26.542 1.00 4.47 ATOM 1594 C ALA L 174 7.156 7.374 28.522 1.00 8.50 ATOM 1595 O ALA L 174 6.346 7.968 29.237 1.00 7.42 ATOM 1596 N SERL 175 8.060 6.527 28.988 1.00 8.85 ATOM 1598 CA SERL 175 8.159 6.230 30.403 1.00 9.69 ATOM 1599 CB SERL 175 7.271 5.021 30.757 1.00 8.09 ATOM 1600 OG SERL 175 7.689 3.814 30.105 1.00 12.41 ATOM 1602 C SERL 175 9.605 5.954 30.779 1.00 10.11 ATOM 1603 O SERL 175 10.411 5.525 29.919 1.00 9.58 ATOM 1604 N SERL 176 9.977 6.234 32.047 1.00 6.07 ATOM 1606 CA SERL 176 11.314 5.932 32.491 1.00 3.46 ATOM 1607 CB SERL 176 12.184 7.164 32.459 1.00 2.00 ATOM 1608 OG SERL 176 13.552 6.858 32.672 1.00 2.00 ATOM 1610 C SERL 176 11.231 5.316 33.891 1.00 5.39 ATOM 1611 0 SERL 176 10.250 5.490 34.564 1.00 7.78 ATOM 1612 N TYRL 177 12.225 4.527 34.231 1.00 6.76 ATOM 1614 CA TYRL 177 12.241 3.756 35.441 1.00 8.12 ATOM 1615 CB TYRL 177 12.040 2.273 35.114 1.00 6.07 ATOM 1616 CG TYRL 177 10.666 1.876 34.571 1.00 6.17 ATOM 1617 CD1 TYRL 177 9.606 1.588 35.440 1.00 6.94 ATOM 1618 CE1 TYRL 177 8.349 1.237 34.936 1.00 8.14 ATOM 1619 CD2 TYRL 177 10.422 1.793 33.200 1.00 6.52 ATOM 1620 CE2 TYRL 177 9.168 1.445 32.703 1.00 7.03 ATOM 1621 CZ TYRL 177 8.134 1.170 33.568 1.00 6.45 ATOM 1622 OH TYRL 177 6.868 0.863 33.077 1.00 6.11 ATOM 1624 C TYRL 177 13.563 3.877 36.093 1.00 6.87 ATOM 1625 O TYRL 177 14.572 3.831 35.422 1.00 9.13 ATOM 1626 N LEUL 178 13.555 4.030 37.390 1.00 6.48 ATOM 1628 CA LEUL 178 14.757 3.989 38.155 1.00 6.11 ATOM 1629 CB LEUL 178 14.992 5.304 38.851 1.00 6.46 ATOM 1630 CG LEU L 178 16.223 5.442 39.717 1.00 7.03 ATOM 1631 CD1 LEU L 178 17.486 5.050 38.981 1.00 10.30 ATOM 1632 CD2 LEU L 178 16.302 6.871 40.214 1.00 13.82 ATOM 1633 C LEUL 178 14.621 2.881 39.154 1.00 8.35 ATOM 1634 O LEU L 178 13.684 2.853 39.899 1.00 10.42 ATOM 1635 N THRL 179 15.562 1.969 39.137 1.00 11.56 ATOM 1637 CA THRL 179 15.533 0.803 39.975 1.00 13.47 ATOM 1638 CB THRL 179 15.700 -0.458 39.109 1.00 15.12 ATOM 1639 OGI THRL 179 14.533 -0.594 38.335 1.00 14.73 ATOM 1641 CG2THRL 179 15.877 -1.731 39.945 1.00 19.56 ATOM 1642 C THRL 179 16.622 0.899 41.026 1.00 16.41 ATOM 1643 O THRL 179 17.818 1.131 40.717 1.00 15.41 ATOM 1644 N LEU L 180 16.179 0.754 42.267 1.00 16.98 ATOM 1646 CA LEUL 180 17.023 0.921 43.402 1.00 17.38 ATOM 1647 CB LEU L 180 16.617 2.198 44.178 1.00 17.62 ATOM 1648 CG LEU L 180 16.662 3.554 43.451 1.00 18.66 ATOM 1649 CDI LEU L 180 16.088 4.652 44.341 1.00 15.82 ATOM 1650 CD2 LEU L 180 18.095 3.911 43.065 1.00 19.60 ATOM 1651 C LEUL 180 16.795 -0.231 44.317 1.00 15.89 ATOM 1652 O LEU L 180 15.745 -0.869 44.249 1.00 20.00 ATOM 1653 N THRL 181 17.772 -0.505 45.141 1.00 16.39 ATOM 1655 CA THRL 181 17.568 -1.429 46.251 1.00 16.84 ATOM 1656 CB THRL 181 18.896 -1.823 46.933 1.00 15.01 ATOM 1657 OGI THRL 181 19.588 -0.632 47.377 1.00 18.96 ATOM 1659 CG2THRL 181 19.784 -2.619 45.988 1.00 16.62 ATOM 1660 C THRL 181 16.757 -0.659 47.281 1.00 14.44 ATOM 1661 O THRL 181 16.709 0.580 47.225 1.00 16.04 ATOM 1662 N ALA L 182 16.125 -1.333 48.209 1.00 15.12 WO 99/10379 PCT/GB98/02542 -181 ATOM 1664 CA ALA L 182 15.433 -0.599 49.267 1.00 13.02 ATOM 1665 CB ALA L 182 14.687 -1.565 50.182 1.00 13.78 ATOM 1666 C ALA L 182 16.448 0.264 50.092 1.00 14.39 ATOM 1667 O ALA L 182 16.130 1.387 50.509 1.00 16.28 ATOM 1668 N ARG L 183 17.676 -0.237 50.310 1.00 14.52 ATOM 1670 CA ARG L 183 18.648 0.523 51.082 1.00 16.24 ATOM 1671 CB ARG L 183 19.921 -0.291 51.326 1.00 19.45 ATOM 1672 CG ARG L 183 21.102 0.533 51.850 1.0024.50 ATOM 1673 CD ARG L 183 22.136 -0.338 52.559 1.0029.62 ATOM 1674 NE ARG L 183 23.493 0.292 52.608 1.00 35.27 ATOM 1676 CZ ARG L 183 24.446 -0.025 53.534 1.00 35.81 ATOM 1677 NH1 ARG L 183 25.675 0.517 53.472 1.00 35.30 ATOM 1680 NH2 ARG L 183 24.152 -0.841 54.534 1.00 36.43 ATOM 1683 C ARG L 183 18.953 1.862 50.414 1.00 18.26 ATOM 1684 O ARG L 183 18.907 2.894 51.070 1.00 19.19 ATOM 1685 N ALAL 184 19.225 1.853 49.099 1.00 16.18 ATOM 1687 CA ALA L 184 19.485 3.073 48.394 1.00 10.91 ATOM 1688 CB ALA L 184 19.784 2.741 46.944 1.00 9.98 ATOM 1689 C ALA L 184 18.280 4.006 48.509 1.00 12.19 ATOM 1690 O ALA L 184 18.419 5.219 48.696 1.00 11.01 ATOM 1691 N TRPL 185 17.086 3.448 48.419 1.00 10.53 ATOM 1693 CA TRP L 185 15.876 4.254 48.476 1.00 11.80 ATOM 1694 CB TRPL 185 14.661 3.373 48.247 1.00 11.64 ATOM 1695 CG TRPL 185 13.419 4.037 48.677 1.00 9.64 ATOM 1696 CD2 TRP L 185 12.835 5.234 48.127 1.00 14.47 ATOM 1697 CE2 TRP L 185 11.640 5.477 48.834 1.00 14.89 ATOM 1698 CE3 TRP L 185 13.193 6.124 47.097 1.00 14.90 ATOM 1699 CDI TRP L 185 12.589 3.618 49.671 1.00 15.33 ATOM 1700 NEI TRPL 185 11.530 4.481 49.749 1.00 15.12 ATOM 1702 CZ2 TRP L 185 10.804 6.560 48.553 1.00 15.58 ATOM 1703 CZ3 TRP L 185 12.368 7.185 46.812 1.00 12.52 ATOM 1704 CH2 TRP L 185 11.186 7.397 47.541 1.00 12.84 ATOM 1705 C TRPL 185 15.702 5.014 49.807 1.00 16.85 ATOM 1706 O TRPL 185 15.357 6.209 49.811 1.00 15.42 ATOM 1707 N GLUL 186 15.928 4.327 50.930 1.00 16.92 ATOM 1709 CA GLU L 186 15.739 4.959 52.239 1.00 19.08 ATOM 1710 CB GLUL 186 15.777 3.908 53.352 1.0021.77 ATOM 1711 CG GLUL 186 14.991 2.625 53.087 1.0025.99 ATOM 1712 CD GLUL 186 15.309 1.533 54.128 0.5026.59 ATOM 1713 OEI GLUL 186 16.198 1.755 54.966 0.5023.57 ATOM 1714 OE2 GLU L 186 14.674 0.457 54.095 0.50 23.36 ATOM 1715 C GLUL 186 16.831 5.972 52.544 1.00 20.25 ATOM 1716 O GLUL 186 16.675 6.841 53.407 1.0020.91 ATOM 1717 N ARG L 187 17.952 5.850 51.875 1.00 18.94 ATOM 1719 CA ARG L 187 19.087 6.649 52.227 1.00 18.58 ATOM 1720 CB ARGL 187 20.330 5.943 51.777 1.0020.96 ATOM 1721 CG ARG L 187 21.508 6.859 51.649 1.0027.24 ATOM 1722 CD ARG L 187 22.605 6.165 50.910 1.0036.91 ATOM 1723 NE ARG L 187 23.278 5.168 51.730 1.00 39.36 ATOM 1725 CZ ARG L 187 24.599 5.050 51.731 1.0042.54 ATOM 1726 NH1 ARG L 187 25.192 4.147 52.498 1.00 45.47 ATOM 1729 NH2ARGL 187 25.330 5.841 50.948 1.00 46.06 ATOM 1732 C ARG L 187 19.054 8.072 51.679 1.00 18.28 ATOM 1733 O ARG L 187 19.749 8.944 52.205 1.00 20.00 ATOM 1734 N HISL 188 18.277 8.324 50.623 1.00 17.48 ATOM 1736 CA HIS L 188 18.250 9.671 50.014 1.00 16.15 ATOM 1737 CB HIS L 188 18.574 9.596 48.475 1.00 13.42 ATOM 1738 CG HIS L 188 19.894 8.957 48.210 1.00 14.37 ATOM 1739 CD2 HIS L 188 20.268 7.652 48.233 1.00 15.01 ATOM 1740 ND1 HIS L 188 21.083 9.664 48.217 1.00 14.95 ATOM 1742 CE1 HIS L 188 22.132 8.871 48.278 1.00 13.98 ATOM 1743 NE2 HIS L 188 21.646 7.644 48.301 1.00 15.86 ATOM 1745 C HISL 188 16.898 10.317 50.245 1.00 16.60 ATOM 1746 O HISL 188 15.897 9.616 50.404 1.00 18.56 ATOM 1747 N SERL 189 16.868 11.658 50.300 1.00 18.06 ATOM 1749 CA SERL 189 15.605 12.392 50.478 1.00 17.30 ATOM 1750 CB SERL 189 15.809 13.590 51.419 1.0020.51 ATOM 1751 OG SERL 189 16.974 14.322 51.095 1.00 18.48 ATOM 1753 C SERL 189 15.061 12.894 49.153 1.00 18.08 ATOM 1754 O SERL 189 13.853 12.896 48.923 1.0021.50 ATOM 1755 N SERL 190 15.967 13.277 48.262 1.00 17.95 ATOM 1757 CA SERL 190 15.582 13.885 46.984 1.00 17.18 WO 99/10379 PCT/GB98/02542 -182 ATOM 1758 CB SERL 190 16.455 15.103 46.722 1.00 14.84 ATOM 1759 OG SERL 190 15.885 15.899 45.705 1.00 24.95 ATOM 1761 C SERL 190 15.694 12.933 45.810 1.00 15.72 ATOM 1762 O SERL 190 16.732 12.295 45.605 1.00 16.39 ATOM 1763 N TYRL 191 14.628 12.850 45.058 1.00 15.74 ATOM 1765 CA TYRL 191 14.620 12.066 43.811 1.00 18.47 ATOM 1766 CB TYRL 191 13.883 10.737 44.028 1.0020.26 ATOM 1767 CG TYRL 191 14.571 9.846 45.036 1.00 20.87 ATOM 1768 CD1 TYR L 191 15.609 9.014 44.623 1.0023.39 ATOM 1769 CEI TYR L 191 16.310 8.223 45.512 1.0022.95 ATOM 1770 CD2TYRL 191 14.227 9.864 46.412 1.0024.18 ATOM 1771 CE2TYRL 191 14.929 9.066 47.317 1.0026.25 ATOM 1772 CZ TYRL 191 15.986 8.247 46.847 1.0026.73 ATOM 1773 OH TYRL 191 16.779 7.529 47.725 1.0030.08 ATOM 1775 C TYR L 191 13.935 12.894 42.700 1.00 17.55 ATOM 1776 O TYRL 191 12.932 13.528 42.950 1.00 14.74 ATOM 1777 N SERL 192 14.465 12.884 41.473 1.00 16.33 ATOM 1779 CA SERL 192 13.898 13.735 40.454 1.00 15.90 ATOM 1780 CB SER L 192 14.701 15.039 40.443 1.00 18.03 ATOM 1781 OG SERL 192 14.126 15.961 39.550 1.0023.10 ATOM 1783 C SER L 192 13.953 13.134 39.074 1.00 12.29 ATOM 1784 O SER L 192 14.990 12.656 38.672 1.00 14.68 ATOM 1785 N CYSL 193 12.855 13.191 38.355 1.00 11.59 ATOM 1787 CA CYS L 193 12.853 12.802 36.945 1.00 14.23 ATOM 1788 CB CYS L 193 11.629 11.969 36.620 1.00 15.78 ATOM 1789 SG CYSL 193 11.551 11.355 34.910 1.00 15.09 ATOM 1790 C CYS L 193 12.850 14.061 36.089 1.00 12.46 ATOM 1791 O CYSL 193 11.931 14.841 36.189 1.00 14.42 ATOM 1792 N GLN L 194 13.866 14.264 35.249 1.00 14.04 ATOM 1794 CA GLN L 194 13.938 15.495 34.451 1.00 14.30 ATOM 1795 CB GLN L 194 15.219 16.234 34.720 1.0020.47 ATOM 1796 CG GLN L 194 15.534 16.382 36.170 1.0026.89 ATOM 1797 CD GLN L 194 16.720 17.269 36.375 1.00 33.09 ATOM 1798 OE1 GLN L 194 16.900 17.827 37.468 1.00 36.67 ATOM 1799 NE2 GLN L 194 17.551 17.413 35.332 1.0036.22 ATOM 1802 C GLN L 194 13.882 15.206 32.984 1.00 13.96 ATOM 1803 O GLNL 194 14.743 14.534 32.463 1.00 11.43 ATOM 1804 N VAL L 195 12.885 15.763 32.339 1.00 13.39 ATOM 1806 CA VALL 195 12.624 15.500 30.942 1.00 15.15 ATOM 1807 CB VALL 195 11.177 15.057 30.783 1.00 13.26 ATOM 1808 CG1 VAL L 195 10.871 14.802 29.321 1.00 12.28 ATOM 1809 CG2 VAL L 195 10.912 13.829 31.659 1.00 8.74 ATOM 1810 C VAL L 195 12.836 16.749 30.071 1.00 16.35 ATOM 1811 0 VALL 195 12.025 17.685 30.106 1.00 15.34 ATOM 1812 N THRL 196 13.925 16.755 29.301 1.00 16.92 ATOM 1814 CA THRL 196 14.195 17.864 28.382 1.00 15.93 ATOM 1815 CB THRL 196 15.708 18.008 28.168 1.00 18.12 ATOM 1816 OGI THRL 196 16.349 18.212 29.431 1.00 22.55 ATOM 1818 CG2THRL 196 16.022 19.183 27.264 1.0021.24 ATOM 1819 C THRL 196 13.507 17.634 27.035 1.00 16.18 ATOM 1820 O THRL 196 13.738 16.581 26.401 1.00 14.99 ATOM 1821 N HIS L 197 12.654 18.626 26.614 1.00 14.43 ATOM 1823 CA HIS L 197 11.933 18.569 25.350 1.00 13.60 ATOM 1824 CB HIS L 197 10.444 18.344 25.574 1.00 12.56 ATOM 1825 CG HIS L 197 9.598 18.345 24.318 1.00 9.47 ATOM 1826 CD2 HIS L 197 9.559 17.496 23.283 1.00 8.75 ATOM 1827 ND1 HIS L 197 8.524 19.223 24.096 1.00 13.69 ATOM 1829 CEl HIS L 197 7.874 18.920 22.993 1.00 10.65 ATOM 1830 NE2 HIS L 197 8.493 17.880 22.507 1.00 13.24 ATOM 1832 C HIS L 197 12.079 19.889 24.609 1.00 19.15 ATOM 1833 O HISL 197 11.361 20.879 24.932 1.0021.46 ATOM 1834 N GLU L 198 12.904 19.875 23.571 1.00 19.88 ATOM 1836 CA GLUL 198 13.178 21.067 22.771 1.0023.30 ATOM 1837 CB GLUL 198 11.897 21.658 22.160 1.0025.45 ATOM 1838 CG GLU L 198 11.074 20.703 21.325 1.0025.96 ATOM 1839 CD GLUL 198 11.437 20.714 19.863 1.0029.67 ATOM 1840 OEI GLU L 198 12.403 20.003 19.479 1.00 31.64 ATOM 1841 OE2GLUL 198 10.744 21.423 19.089 1.0027.15 ATOM 1842 C GLU L 198 13.840 22.126 23.632 1.0025.19 ATOM 1843 O GLU L 198 13.378 23.250 23.683 1.00 25.37 ATOM 1844 N GLY L 199 14.874 21.736 24.360 1.00 26.71 ATOM 1846 CA GLY L 199 15.647 22.699 25.107 1.00 28.67 WO 99/10379 PCT/GB98/02542 -183 ATOM 1847 C GLY L 199 15.025 23.177 26.398 1.00 30.20 ATOM 1848 O GLY L 199 15.631 24.007 27.078 1.00 31.36 ATOM 1849 N HIS L200 13.821 22.685 26.738 1.0029.31 ATOM 1851 CA HIS L 200 13.164 23.095 27.979 1.0029.70 ATOM 1852 CB HIS L200 11.788 23.748 27.741 1.0034.13 ATOM 1853 CG HIS L 200 11.606 24.407 26.407 1.0042.18 ATOM 1854 CD2 HIS L 200 12.497 24.946 25.537 1.00 44.52 ATOM 1855 NDI HIS L 200 10.379 24.476 25.758 1.00 45.60 ATOM 1857 CEl HIS L 200 10.501 25.004 24.543 1.0046.26 ATOM 1858 NE2 HIS L 200 11.777 25.293 24.405 1.00 46.19 ATOM 1860 C HIS L 200 12.959 21.876 28.832 1.00 27.60 ATOM 1861 O HIS L 200 12.335 20.909 28.372 1.0027.65 ATOM 1862 N THR L 201 13.458 21.932 30.064 1.0027.03 ATOM 1864 CA THR L 201 13.375 20.797 30.979 1.0025.96 ATOM 1865 CB THR L 201 14.629 20.751 31.867 1.0022.54 ATOM 1866 OGI THR L 201 15.756 20.698 31.036 1.00 21.22 ATOM 1868 CG2THR L 201 14.670 19.519 32.748 1.0022.94 ATOM 1869 C THRL 201 12.109 20.851 31.845 1.00 26.78 ATOM 1870 O THR L 201 11.855 21.863 32.498 1.0029.53 ATOM 1871 N VAL L 202 11.274 19.784 31.774 1.0025.81 ATOM 1873 CA VAL L 202 10.113 19.636 32.674 1.0022.79 ATOM 1874 CB VAL L 202 8.877 19.139 31.905 1.0024.16 ATOM 1875 CG1 VAL L 202 7.656 19.088 32.826 1.00 24.52 ATOM 1876 CG2VAL L 202 8.621 20.060 30.717 1.0024.14 ATOM 1877 C VAL L 202 10.492 18.614 33.772 1.0021.74 ATOM 1878 0 VAL L 202 10.951 17.538 33.472 1.00 19.01 ATOM 1879 N GLU L 203 10.315 18.949 35.044 1.0020.40 ATOM 1881 CA GLU L 203 10.780 18.077 36.078 1.00 19.67 ATOM 1882 CB GLU L 203 12.018 18.713 36.708 1.0022.14 ATOM 1883 CG GLU L 203 12.565 17.936 37.876 1.0027.78 ATOM 1884 CD GLU L 203 13.321 18.815 38.856 0.5030.15 ATOM 1885 OE1 GLU L 203 14.570 18.902 38.736 0.50 30.52 ATOM 1886 OE2 GLU L 203 12.662 19.418 39.748 0.50 30.93 ATOM 1887 C GLU L 203 9.736 17.757 37.155 1.00 18.69 ATOM 1888 O GLU L 203 8.856 18.556 37.465 1.00 19.41 ATOM 1889 N LYS L 204 9.810 16.552 37.676 1.00 16.36 ATOM 1891 CA LYS L 204 9.052 16.197 38.843 1.0014.59 ATOM 1892 CB LYS L 204 7.969 15.235 38.542 1.00 15.55 ATOM 1893 CG LYS L 204 6.861 15.888 37.769 1.0021.54 ATOM 1894 CD LYS L 204 6.406 17.133 38.481 1.0021.69 ATOM 1895 CE LYS L 204 5.275 17.775 37.720 1.0022.39 ATOM 1896 NZ LYS L 204 4.051 16.981 37.871 1.0020.85 ATOM 1900 C LYS L204 9.994 15.617 39.854 1.00 15.55 ATOM 1901 O LYS L204 11.022 14.984 39.499 1.00 13.34 ATOM 1902 N SER L 205 9.673 15.854 41.125 1.00 17.28 ATOM 1904 CA SERL 205 10.536 15.433 42.199 1.00 16.96 ATOM 1905 CB SER L 205 11.321 16.626 42.766 1.00 18.69 ATOM 1906 OG SER L 205 12.422 16.990 41.919 1.00 25.46 ATOM 1908 C SER L 205 9.743 14.825 43.299 1.00 16.29 ATOM 1909 O SERL 205 8.584 15.118 43.445 1.00 12.40 ATOM 1910 N LEU L 206 10.409 13.959 44.032 1.00 17.28 ATOM 1912 CA LEU L 206 9.869 13.340 45.223 1.00 20.60 ATOM 1913 CB LEU L 206 9.926 11.804 45.106 1.00 18.66 ATOM 1914 CG LEU L 206 9.060 11.155 44.021 1.00 17.51 ATOM 1915 CD1 LEU L 206 9.529 9.738 43.756 1.00 19.23 ATOM 1916 CD2LEU L 206 7.587 11.167 44.424 1.00 16.04 ATOM 1917 C LEU L 206 10.748 13.756 46.392 1.00 22.29 ATOM 1918 O LEU L 206 11.966 13.806 46.263 1.0020.72 ATOM 1919 N SER L 207 10.137 14.114 47.488 1.0026.92 ATOM 1921 CA SERL 207 10.898 14.334 48.709 1.00 33.08 ATOM 1922 CB SER L 207 10.508 15.631 49.412 1.0032.95 ATOM 1923 OG SER L 207 11.284 15.814 50.584 1.0035.61 ATOM 1925 C SERL 207 10.580 13.160 49.618 1.00 35.86 ATOM 1926 O SER L 207 9.401 12.806 49.798 1.0038.31 ATOM 1927 N ARG L 208 11.603 12.538 50.143 1.0036.32 ATOM 1929 CA ARG L 208 11.421 11.382 50.977 1.00 36.19 ATOM 1930 CB ARG L 208 12.244 10.211 50.365 1.0033.25 ATOM 1931 CG ARG L 208 11.945 8.857 50.961 1.0031.97 ATOM 1932 CD ARG L 208 13.215 8.117 51.322 1.0032.82 ATOM 1933 NE ARG L 208 13.075 7.314 52.547 1.0037.28 ATOM 1935 CZ ARG L 208 13.873 7.494 53.619 1.0043.16 ATOM 1936 NHI ARG L 208 13.749 6.729 54.723 1.00 43.30 WO 99/10379 PCT/GB98/02542 -184 ATOM 1939 NH2 ARG L 208 14.794 8.460 53.596 1.00 45.46 ATOM 1942 C ARG L208 11.855 11.788 52.407 1.00 37.35 ATOM 1943 OTI ARG L 208 12.824 11.196 52.969 1.00 38.30 ATOM 1944 OT2 ARG L 208 11.246 12.774 52.926 1.00 37.56 ATOM 1945 CB ALA H 1 -0.771 -4.993 -4.626 1.00 35.02 ATOM 1946 C ALA H 1 1.178 -6.505 -4.919 1.00 32.62 ATOM 1947 O ALA H 1 0.788 -7.588 -4.494 1.00 32.59 ATOM 1950 N ALA H 1 -0.545 -6.367 -6.682 1.00 37.70 ATOM 1952 CA ALA H 1 0.204 -5.591 -5.634 1.00 34.79 ATOM 1953 N VAL H 2 2.429 -6.057 -4.804 1.0029.87 ATOM 1955 CA VALH 2 3.463 -6.831 -4.147 1.0028.68 ATOM 1956 CB VAL H 2 4.806 -6.124 -4.242 1.00 27.24 ATOM 1957 CG1 VAL H 2 5.892 -6.933 -3.552 1.00 30.14 ATOM 1958 CG2 VAL H 2 5.136 -5.894 -5.708 1.00 30.41 ATOM 1959 C VALH 2 3.135 -7.053 -2.694 1.0027.59 ATOM 1960 0 VAL H 2 2.532 -6.207 -2.034 1.0027.26 ATOM 1961 N GLNH 3 3.506 -8.200 -2.213 1.0025.47 ATOM 1963 CA GLN H 3 3.315 -8.504 -0.833 1.00 24.24 ATOM 1964 CB GLN H 3 1.885 -9.027 -0.578 1.00 26.56 ATOM 1965 CG GLN H 3 1.609 -9.380 0.905 1.00 33.26 ATOM 1966 CD GLN H 3 0.370 -10.261 1.157 1.00 38.06 ATOM 1967 OE1 GLNH 3 0.094-11.216 0.415 1.00 40.20 ATOM 1968 NE2 GLN H 3 -0.369 -9.958 2.240 1.00 38.60 ATOM 1971 C GLN H 3 4.334 -9.535 -0.380 1.00 21.45 ATOM 1972 O GLN H 3 4.464 -10.584 -0.995 1.00 22.59 ATOM 1973 N LEU H 4 5.099 -9.192 0.641 1.00 19.37 ATOM 1975 CA LEU H 4 5.998 -10.150 1.300 1.00 16.61 ATOM 1976 CB LEU H 4 7.394 -9.545 1.486 1.00 13.50 ATOM 1977 CG LEUH 4 8.174 -9.232 0.194 1.00 8.19 ATOM 1978 CD1 LEU H 4 9.510 -8.607 0.523 1.00 3.80 ATOM 1979 CD2 LEU H 4 8.394 -10.506 -0.603 1.00 8.33 ATOM 1980 C LEU H 4 5.388 -10.500 2.669 1.00 15.88 ATOM 1981 O LEUH 4 4.960 -9.611 3.396 1.00 15.82 ATOM 1982 N GLNH 5 5.324-11.767 3.017 1.00 14.17 ATOM 1984 CA GLN H 5 4.655 -12.155 4.267 1.00 15.42 ATOM 1985 CB GLN H 5 3.283 -12.680 3.908 1.00 16.35 ATOM 1986 CG GLNH 5 2.311 -12.925 5.035 1.0022.48 ATOM 1987 CD GLN H 5 1.003 -13.532 4.494 1.00 29.57 ATOM 1988 OEI GLN H 5 0.366 -14.355 5.154 1.00 35.66 ATOM 1989 NE2 GLN H 5 0.593 -13.150 3.278 1.00 31.58 ATOM 1992 C GLN H 5 5.470 -13.205 5.002 1.00 13.97 ATOM 1993 O GLNH 5 5.590-14.349 4.539 1.00 9.52 ATOM 1994 N GLU H 6 6.059 -12.801 6.131 1.00 13.08 ATOM 1996 CA GLU H 6 6.917 -13.705 6.900 1.00 9.47 ATOM 1997 CB GLU H 6 7.848 -12.956 7.823 1.00 9.95 ATOM 1998 CG GLU H 6 8.813 -12.021 7.131 1.00 9.95 ATOM 1999 CD GLU H 6 8.237 -10.662 6.799 1.00 5.17 ATOM 2000 OEI GLUH 6 9.055 -9.778 6.461 1.00 8.80 ATOM 2001 OE2 GLU H 6 6.983 -10.462 6.843 1.00 4.90 ATOM 2002 C GLU H 6 6.088 -14.632 7.736 1.00 12.71 ATOM 2003 O GLUH 6 4.884-14.408 7.914 1.00 13.94 ATOM 2004 N SERH 7 6.742-15.650 8.270 1.00 13.48 ATOM 2006 CA SERH 7 6.095 -16.642 9.106 1.00 13.96 ATOM 2007 CB SERH 7 5.381 -17.653 8.220 1.00 15.10 ATOM 2008 OG SERH 7 4.049-17.289 8.102 1.0023.26 ATOM 2010 C SERH 7 7.104-17.404 9.919 1.00 12.29 ATOM 2011 O SERH 7 8.268 -17.411 9.591 1.00 13.84 ATOM 2012 N GLYH 8 6.622-18.093 10.961 1.00 12.53 ATOM 2014 CA GLYH 8 7.462-19.033 11.663 1.00 10.51 ATOM 2015 C GLYH 8 8.096-18.494 12.907 1.00 12.14 ATOM 2016 O GLYH 8 8.763-19.233 13.581 1.00 16.56 ATOM 2017 N GLYH 9 7.903-17.217 13.236 1.00 10.59 ATOM 2019 CA GLY H 9 8.527 -16.709 14.450 1.00 14.05 ATOM 2020 C GLY H 9 7.920 -17.295 15.753 1.00 16.57 ATOM 2021 O GLY H 9 6.760 -17.800 15.770 1.00 17.72 ATOM 2022 N GLY H 10 8.667 -17.200 16.843 1.00 16.58 ATOM 2024 CA GLYH 10 8.149-17.666 18.129 1.00 15.33 ATOM 2025 C GLYH 10 9.140-17.445 19.220 1.00 12.28 ATOM 2026 O GLYH 10 10.150-16.758 19.006 1.00 11.60 ATOM 2027 N LEU H 11 8.841 -18.042 20.383 1.00 13.95 ATOM 2029 CA LEUH 11 9.706-17.995 21.590 1.00 14.48 ATOM 2030 CB LEU H 11 8.814-18.096 22.825 1.00 14.29 WO 99/10379 PCT/GB98/02542 -185 ATOM 2031 CG LEUH 11 9.200-17.433 24.155 1.00 13.64 ATOM 2032 CDI LEUH 11 8.420-18.169 25.235 1.00 13.85 ATOM 2033 CD2 LEU H 11 10.696 -17.445 24.479 1.00 4.07 ATOM 2034 C LEU H 11 10.586 -19.229 21.577 1.00 14.46 ATOM 2035 O LEU H 11 10.096 -20.290 21.346 1.00 15.77 ATOM 2036 N VALH 12 11.855-19.096 21.901 1.00 18.00 ATOM 2038 CA VAL H 12 12.774 -20.220 21.888 1.00 15.52 ATOM 2039 CB VAL H 12 13.455 -20.297 20.469 1.00 18.43 ATOM 2040 CGI VAL H 12 14.970-20.237 20.592 1.00 13.84 ATOM 2041 CG2 VAL H 12 13.024 -21.558 19.726 1.00 16.77 ATOM 2042 C VAL H 12 13.832 -20.013 22.992 1.00 15.38 ATOM 2043 0 VAL H 12 14.172 -18.875 23.352 1.00 13.69 ATOM 2044 N GLN H 13 14.355 -21.090 23.558 1.00 16.57 ATOM 2046 CA GLN H 13 15.372 -20.934 24.580 1.00 15.98 ATOM 2047 CB GLNH 13 15.310-22.083 25.580 1.00 19.24 ATOM 2048 CG GLN H 13 14.104 -22.074 26.537 1.0026.05 ATOM 2049 CD GLN H 13 14.446 -22.629 27.939 1.0028.25 ATOM 2050 OEI GLN H 13 15.429-23.367 28.124 1.0031.14 ATOM 2051 NE2 GLN H 13 13.645 -22.259 28.945 1.00 33.04 ATOM 2054 C GLN H 13 16.729 -20.924 23.920 1.00 14.00 ATOM 2055 O GLN H 13 16.870 -21.344 22.773 1.00 15.42 ATOM 2056 N PRO H 14 17.722 -20.356 24.540 1.00 12.23 ATOM 2057 CD PRO H 14 17.659 -19.512 25.729 1.00 12.38 ATOM 2058 CA PRO H 14 19.046 -20.372 23.965 1.00 12.75 ATOM 2059 CB PRO H 14 19.907 -19.769 25.057 1.00 10.09 ATOM 2060 CG PRO H 14 18.951 -18.757 25.601 1.00 13.06 ATOM 2061 C PRO H 14 19.398-21.817 23.621 1.00 14.12 ATOM 2062 O PRO H 14 19.080 -22.734 24.394 1.00 16.21 ATOM 2063 N GLYH 15 20.019-22.013 22.451 1.00 10.07 ATOM 2065 CA GLY H 15 20.300-23.355 21.945 1.00 7.80 ATOM 2066 C GLY H 15 19.221 -23.789 20.965 1.00 5.91 ATOM 2067 O GLY H 15 19.394 -24.744 20.198 1.00 6.43 ATOM 2068 N GLY H 16 18.137 -23.048 20.952 1.00 2.35 ATOM 2070 CA GLY H 16 17.015 -23.406 20.134 1.00 6.43 ATOM 2071 C GLY H 16 17.260 -23.284 18.627 1.00 6.38 ATOM 2072 O GLY H 16 18.264 -22.765 18.168 1.00 6.92 ATOM 2073 N SER H 17 16.262 -23.672 17.887 1.00 12.18 ATOM 2075 CA SERH 17 16.323 -23.705 16.436 1.00 11.41 ATOM 2076 CB SERH 17 16.774-25.123 16.079 1.00 15.73 ATOM 2077 OG SERH 17 16.883 -25.332 14.702 1.00 22.31 ATOM 2079 C SERH 17 14.909-23.414 15.882 1.00 12.78 ATOM 2080 O SERH 17 13.930-23.826 16.500 1.00 16.32 ATOM 2081 N MET H 18 14.783 -22.667 14.769 1.00 8.79 ATOM 2083 CA MET H 18 13.488 -22.464 14.117 1.00 10.28 ATOM 2084 CB MET H 18 12.565 -21.433 14.815 1.00 13.63 ATOM 2085 CG METH 18 13.176-20.133 15.324 1.00 16.88 ATOM 2086 SD MET H 18 11.965 -19.096 16.237 1.00 27.06 ATOM 2087 CE METH 18 10.504-20.163 16.269 1.00 3.15 ATOM 2088 C MET H 18 13.665 -22.059 12.668 1.00 9.07 ATOM 2089 O METH 18 14.738-21.626 12.254 1.00 10.49 ATOM 2090 N LYSH 19 12.612-22.185 11.907 1.00 10.93 ATOM 2092 CA LYS H 19 12.675 -21.815 10.531 1.00 11.83 ATOM 2093 CB LYS H 19 12.600 -23.056 9.625 1.00 14.90 ATOM 2094 CG LYS H 19 12.550 -22.773 8.094 1.00 17.52 ATOM 2095 CD LYS H 19 13.043 -23.984 7.299 1.00 20.23 ATOM 2096 CE LYS H 19 12.526 -24.038 5.865 1.00 19.51 ATOM 2097 NZ LYSH 19 11.280-24.851 5.769 1.0022.58 ATOM 2101 C LYSH 19 11.572-20.843 10.207 1.00 13.18 ATOM 2102 O LYS H 19 10.395 -21.073 10.502 1.00 12.84 ATOM 2103 N LEUH 20 11.995-19.731 9.610 1.00 12.76 ATOM 2105 CA LEUH 20 11.094-18.710 9.160 1.00 9.79 ATOM 2106 CB LEU H 20 11.700-17.326 9.443 1.00 11.85 ATOM 2107 CG LEUH 20 12.231 -17.080 10.874 1.00 9.81 ATOM 2108 CD1 LEU H 20 12.775 -15.658 10.967 1.00 4.16 ATOM 2109 CD2LEUH 20 11.135-17.333 11.908 1.00 4.65 ATOM 2110 C LEU H 20 10.855 -18.856 7.673 1.00 9.78 ATOM 2111 O LEUH 20 11.714-19.325 6.922 1.00 8.56 ATOM 2112 N SERH 21 9.699-18.478 7.281 1.00 9.36 ATOM 2114 CA SERH 21 9.317-18.520 5.911 1.00 13.01 ATOM 2115 CB SER H 21 8.269-19.586 5.707 1.00 14.00 ATOM 2116 OG SER H 21 8.803 -20.857 5.993 1.00 19.15 ATOM 2118 C SERH 21 8.764 -17.193 5.469 1.00 13.78 WO 99/10379 PCT/GB98/02542 -186 ATOM 2119 O SERH 21 8.160-16.471 6.260 1.00 18.18 ATOM 2120 N CYS H 22 9.003 -16.860 4.194 1.00 16.70 ATOM 2122 CA CYS H 22 8.497 -15.627 3.596 1.00 13.01 ATOM 2123 CB CYS H 22 9.603 -14.560 3.511 1.00 11.58 ATOM 2124 SG CYS H 22 9.160 -13.148 2.429 1.00 13.80 ATOM 2125 C CYSH 22 7.993-15.912 2.193 1.00 11.47 ATOM 2126 O CYS H 22 8.708 -16.423 1.375 1.00 13.22 ATOM 2127 N VAL H 23 6.768 -15.578 1.938 1.00 14.16 ATOM 2129 CA VALH 23 6.184-15.802 0.639 1.00 16.31 ATOM 2130 CB VAL H 23 4.857 -16.604 0.748 1.00 17.85 ATOM 2131 CGI VALH 23 5.151-17.911 1.457 1.0021.18 ATOM 2132 CG2 VAL H 23 3.799 -15.822 1.518 1.00 19.36 ATOM 2133 C VALH 23 5.922-14.476 -0.023 1.00 16.44 ATOM 2134 0 VAL H 23 5.303 -13.570 0.574 1.00 12.06 ATOM 2135 N ALA H 24 6.400 -14.380 -1.263 1.00 19.48 ATOM 2137 CA ALA H 24 6.275 -13.152 -2.068 1.00 19.91 ATOM 2138 CB ALA H 24 7.604 -12.884 -2.748 1.00 18.96 ATOM 2139 C ALAH 24 5.182-13.278 -3.117 1.0021.31 ATOM 2140 O ALA H 24 4.953 -14.374 -3.667 1.00 24.23 ATOM 2141 N SERH 25 4.500-12.194 -3.409 1.00 19.69 ATOM 2143 CA SER H 25 3.488 -12.248 -4.429 1.00 20.48 ATOM 2144 CB SERH 25 2.159-12.558 -3.789 1.00 19.79 ATOM 2145 OG SERH 25 1.875 -11.574 -2.821 1.0022.03 ATOM 2147 C SERH 25 3.390-10.925 -5.133 1.0020.75 ATOM 2148 O SERH 25 3.863 -9.909 -4.618 1.0020.32 ATOM 2149 N GLY H 26 2.746-10.932 -6.294 1.00 22.48 ATOM 2151 CA GLY H 26 2.508 -9.680 -7.010 1.00 24.12 ATOM 2152 C GLYH 26 3.713 -9.139 -7.796 1.0025.02 ATOM 2153 O GLY H 26 3.709 -7.955 -8.176 1.00 22.99 ATOM 2154 N PHE H 27 4.728-10.018 -8.013 1.00 24.04 ATOM 2156 CA PHE H 27 5.932 -9.707 -8.790 1.0022.13 ATOM 2157 CB PHE H 27 6.819 -8.649 -8.091 1.00 23.23 ATOM 2158 CG PHE H 27 7.740 -9.173 -6.996 1.00 20.65 ATOM 2159 CD1 PHEH 27 9.114 -9.356 -7.245 1.00 19.81 ATOM 2160 CD2 PHE H 27 7.255 -9.425 -5.712 1.00 19.64 ATOM 2161 CE1 PHE H 27 9.970 -9.775 -6.231 1.00 18.67 ATOM 2162 CE2PHEH 27 8.117 -9.832 -4.703 1.00 16.42 ATOM 2163 CZ PHE H 27 9.464 -10.010 -4.959 1.00 16.29 ATOM 2164 C PHE H 27 6.736-10.993 -9.003 1.0022.10 ATOM 2165 O PHE H 27 6.519 -12.007 -8.308 1.00 25.47 ATOM 2166 N THRH 28 7.689-10.939 -9.919 1.00 17.46 ATOM 2168 CA THR H 28 8.483 -12.084 -10.233 1.00 16.95 ATOM 2169 CB THRH 28 9.046-11.951-11.625 1.00 18.84 ATOM 2170 OGI THRH 28 7.939-11.733 -12.511 1.00 19.87 ATOM 2172 CG2 THR H 28 9.793 -13.214 -12.017 1.00 17.78 ATOM 2173 C THRH 28 9.594-12.306 -9.258 1.00 16.32 ATOM 2174 O THR H 28 10.757-11.907 -9.499 1.00 13.29 ATOM 2175 N PHEH 29 9.237-13.013 -8.176 1.00 17.39 ATOM 2177 CA PHE H 29 10.185 -13.319 -7.092 1.00 12.65 ATOM 2178 CB PHE H 29 9.520 -14.291 -6.099 1.00 14.38 ATOM 2179 CG PHE H 29 10.415 -14.836 -5.010 1.00 13.29 ATOM 2180 CDI PHE H 29 10.570-14.135 -3.802 1.00 17.17 ATOM 2181 CD2PHEH 29 11.067-16.058 -5.159 1.00 11.79 ATOM 2182 CE1 PHEH 29 11.370-14.654 -2.765 1.00 16.24 ATOM 2183 CE2PHEH 29 11.864-16.586 -4.138 1.00 8.50 ATOM 2184 CZ PHE H 29 12.022-15.887 -2.946 1.00 14.16 ATOM 2185 C PHEH 29 11.482-13.895 -7.605 1.00 11.31 ATOM 2186 O PHEH 29 12.555-13.533 -7.112 1.00 11.15 ATOM 2187 N SERH 30 11.385 -14.789 -8.631 1.00 10.88 ATOM 2189 CA SERH 30 12.565-15.474 -9.210 1.00 10.24 ATOM 2190 CB SERH 30 12.113-16.379-10.389 1.00 10.59 ATOM 2191 OG SERH 30 10.698-16.481 -10.425 1.00 20.09 ATOM 2193 C SERH 30 13.661 -14.529 -9.727 1.00 8.21 ATOM 2194 O SERH 30 14.839-14.924 -9.823 1.00 6.56 ATOM 2195 N ASNH 31 13.257-13.299-10.109 1.00 10.86 ATOM 2197 CA ASN H 31 14.172 -12.323 -10.737 1.00 10.45 ATOM 2198 CB ASNH 31 13.378-11.306-11.569 1.00 13.88 ATOM 2199 CG ASNH 31 12.865-11.830-12.887 1.00 17.90 ATOM 2200 ODI ASN H 31 13.200-12.948-13.307 1.00 17.77 ATOM 2201 ND2ASNH 31 12.035-11.023-13.549 1.0020.48 ATOM 2204 C ASNH 31 15.033-11.520 -9.762 1.00 11.11 ATOM 2205 O ASNH 31 15.987-10.848-10.199 1.00 11.57 WO 99/10379 PCT/GB98/02542 -187 ATOM 2206 N TYRH 32 14.689-11.518 -8.473 1.00 10.42 ATOM 2208 CA TYRH 32 15.459-10.727 -7.512 1.00 7.72 ATOM 2209 CB TYRH 32 14.575 -9.640 -6.921 1.00 10.35 ATOM 2210 CG TYRH 32 13.995 -8.726 -7.958 1.00 10.12 ATOM 2211 CDI TYRH 32 12.717 -8.975 -8.451 1.00 11.35 ATOM 2212 CEl TYR H 32 12.192 -8.238 -9.513 1.00 13.96 ATOM 2213 CD2 TYR H 32 14.752 -7.703 -8.543 1.00 10.05 ATOM 2214 CE2 TYR H 32 14.232 -6.947 -9.624 1.00 10.42 ATOM 2215 CZ TYRH 32 12.948 -7.222-10.096 1.00 13.65 ATOM 2216 OH TYRH 32 12.367 -6.454-11.099 1.00 13.93 ATOM 2218 C TYRH 32 16.069-11.541 -6.376 1.00 8.75 ATOM 2219 O TYRH 32 15.564-12.610 -5.991 1.00 8.92 ATOM 2220 N TRPH 33 17.176-11.022 -5.853 1.00 7.78 ATOM 2222 CA TRP H 33 17.752 -11.580 -4.698 1.00 6.34 ATOM 2223 CB TRPH 33 19.106-10.961 -4.343 1.00 3.32 ATOM 2224 CG TRPH 33 20.136-10.905 -5.409 1.00 5.31 ATOM 2225 CD2 TRP H 33 21.486-10.435 -5.224 1.00 2.32 ATOM 2226 CE2 TRP H 33 22.122 -10.485 -6.481 1.00 3.83 ATOM 2227 CE3 TRP H 33 22.204 -9.973 -4.111 1.00 5.74 ATOM 2228 CD1 TRP H 33 19.998 -11.225 -6.740 1.00 2.00 ATOM 2229 NE1 TRP H 33 21.192 -10.969 -7.368 1.00 3.99 ATOM 2231 CZ2 TRP H 33 23.432 -10.079 -6.667 1.00 5.36 ATOM 2232 CZ3 TRP H 33 23.509 -9.569 -4.289 1.00 8.48 ATOM 2233 CH2 TRP H 33 24.108 -9.621 -5.564 1.00 7.99 ATOM 2234 C TRP H 33 16.815 -11.212 -3.551 1.00 8.26 ATOM 2235 O TRPH 33 16.037-10.228 -3.655 1.00 6.24 ATOM 2236 N METH 34 16.909 -11.993 -2.473 1.00 7.22 ATOM 2238 CA METH 34 16.136-11.747 -1.260 1.00 8.81 ATOM 2239 CB METH 34 15.113 -12.849 -1.097 1.00 7.01 ATOM 2240 CG MET H 34 13.926-12.741 -2.048 1.00 10.07 ATOM 2241 SD METH 34 12.892-11.274 -1.831 1.00 17.49 ATOM 2242 CE MET H 34 11.950-11.773 -0.390 1.00 17.44 ATOM 2243 C METH 34 17.089-11.678 -0.049 1.00 7.51 ATOM 2244 O MET H 34 18.193 -12.255 -0.093 1.00 10.32 ATOM 2245 N ASN H 35 16.724 -10.902 0.988 1.00 6.44 ATOM 2247 CA ASNH 35 17.570-10.757 2.181 1.00 4.54 ATOM 2248 CB ASN H 35 18.186 -9.341 2.317 1.00 5.78 ATOM 2249 CG ASNH 35 18.891 -8.806 1.076 1.00 3.57 ATOM 2250 ODI ASNH 35 20.129 -8.691 1.016 1.00 2.44 ATOM 2251 ND2 ASN H 35 18.102 -8.488 0.098 1.00 2.00 ATOM 2254 C ASN H 35 16.725 -10.942 3.442 1.00 4.23 ATOM 2255 O ASN H 35 15.486-10.826 3.400 1.00 2.00 ATOM 2256 N TRPH 36 17.398-11.276 4.537 1.00 4.82 ATOM 2258 CA TRPH 36 16.746-11.240 5.834 1.00 6.51 ATOM 2259 CB TRPH 36 16.864-12.558 6.601 1.00 4.15 ATOM 2260 CG TRPH 36 15.872-13.568 6.103 1.00 6.17 ATOM 2261 CD2 TRP H 36 14.487 -13.756 6.501 1.00 5.59 ATOM 2262 CE2 TRP H 36 13.954 -14.755 5.666 1.00 7.68 ATOM 2263 CE3TRPH 36 13.621-13.187 7.474 1.00 3.55 ATOM 2264 CDI TRPH 36 16.100-14.433 5.087 1.00 7.43 ATOM 2265 NE1 TRPH 36 14.963-15.123 4.843 1.00 11.31 ATOM 2267 CZ2 TRP H 36 12.625 -15.216 5.745 1.00 7.42 ATOM 2268 CZ3 TRP H 36 12.274 -13.649 7.551 1.00 2.61 ATOM 2269 CH2 TRP H 36 11.798-14.642 6.698 1.00 5.75 ATOM 2270 C TRP H 36 17.375 -10.107 6.625 1.00 3.69 ATOM 2271 O TRPH 36 18.599 -9.923 6.618 1.00 3.88 ATOM 2272 N VAL H 37 16.546 -9.299 7.239 1.00 8.04 ATOM 2274 CA VAL H 37 17.063 -8.196 8.049 1.00 4.88 ATOM 2275 CB VAL H 37 16.851 -6.839 7.327 1.00 7.93 ATOM 2276 CGI1 VALH 37 17.141 -5.666 8.291 1.00 5.70 ATOM 2277 CG2 VAL H 37 17.755 -6.752 6.084 1.00 4.88 ATOM 2278 C VALH 37 16.264 -8.195 9.353 1.00 7.96 ATOM 2279 0 VALH 37 15.041 -8.274 9.288 1.00 10.89 ATOM 2280 N ARG H 38 16.920 -8.092 10.498 1.00 4.79 ATOM 2282 CA ARGH 38 16.179 -8.134 11.783 1.00 6.19 ATOM 2283 CB ARG H 38 16.710 -9.288 12.699 1.00 2.00 ATOM 2284 CG ARGH 38 18.086 -9.070 13.392 1.00 5.85 ATOM 2285 CD ARG H 38 18.656 -10.358 14.059 1.00 7.03 ATOM 2286 NE ARGH 38 20.110-10.251 14.276 1.00 5.02 ATOM 2288 CZ ARG H 38 20.873 -11.259 14.656 1.00 7.94 ATOM 2289 NH1 ARG H 38 22.155 -11.056 14.911 1.00 8.02 ATOM 2292 NH2 ARG H 38 20.371 -12.477 14.749 1.00 10.78 WO 99/10379 PCT/GB98/02542 -188 ATOM 2295 C ARG H 38 16.218 -6.778 12.557 1.00 9.00 ATOM 2296 O ARG H 38 17.166 -5.974 12.456 1.00 7.20 ATOM 2297 N GLN H 39 15.192 -6.533 13.332 1.00 10.07 ATOM 2299 CA GLN H 39 15.154 -5.306 14.106 1.00 13.88 ATOM 2300 CB GLN H 39 13.927 -4.499 13.692 1.00 12.70 ATOM 2301 CG GLN H 39 13.871 -3.134 14.351 1.00 13.88 ATOM 2302 CD GLN H 39 12.577 -2.435 14.096 1.00 10.90 ATOM 2303 OEl GLN H 39 11.578 -3.045 13.669 1.00 14.02 ATOM 2304 NE2 GLN H 39 12.570 -1.148 14.354 1.00 19.33 ATOM 2307 C GLNH 39 15.104 -5.631 15.638 1.00 17.21 ATOM 2308 O GLN H 39 14.152 -6.292 16.096 1.00 11.06 ATOM 2309 N SERH 40 16.149 -5.178 16.387 1.0020.54 ATOM 2311 CA SERH 40 16.224 -5.375 17.840 1.0025.32 ATOM 2312 CB SERH 40 17.438 -6.241 18.210 1.0024.24 ATOM 2313 OG SERH 40 18.604 -5.445 18.333 1.0026.93 ATOM 2315 C SERH 40 16.372 -4.024 18.534 1.0026.35 ATOM 2316 O SERH 40 17.020 -3.133 17.987 1.0027.60 ATOM 2317 N PRO H 41 15.807 -3.856 19.773 1.00 29.80 ATOM 2318 CD PROH 41 15.073 -4.886 20.544 0.5026.67 ATOM 2319 CA PROH 41 15.898 -2.583 20.548 1.0029.86 ATOM 2320 CB PRO H 41 15.219 -2.942 21.868 0.50 28.55 ATOM 2321 CG PRO H 41 15.354 -4.430 21.937 0.50 27.83 ATOM 2322 C PRO H 41 17.364 -2.097 20.737 1.00 33.07 ATOM 2323 O PRO H 41 17.739 -0.945 20.398 1.00 33.27 ATOM 2324 N ALA H 42 18.195 -3.003 21.209 1.00 34.06 ATOM 2326 CA ALA H 42 19.604 -2.687 21.463 1.00 37.51 ATOM 2327 CB ALA H 42 20.217 -3.817 22.304 1.00 37.30 ATOM 2328 C ALA H 42 20.448 -2.486 20.178 1.00 37.45 ATOM 2329 O ALA H 42 21.615 -2.062 20.265 1.00 38.47 ATOM 2330 N LYS H 43 19.875 -2.769 18.997 1.00 36.93 ATOM 2332 CA LYS H 43 20.689 -2.786 17.797 1.00 35.11 ATOM 2333 CB LYS H 43 21.042 -4.231 17.444 1.00 36.81 ATOM 2334 CG LYSH 43 21.939 -4.939 18.459 1.0040.66 ATOM 2335 CD LYSH 43 22.518 -6.260 17.908 1.0040.17 ATOM 2336 CE LYS H 43 21.551 -7.452 18.065 1.00 38.65 ATOM 2337 NZ LYS H 43 22.189 -8.748 17.670 1.00 34.06 ATOM 2341 C LYS H 43 20.078 -2.132 16.570 1.0032.32 ATOM 2342 O LYS H 43 20.735 -2.094 15.541 1.00 32.74 ATOM 2343 N GLYH 44 18.867 -1.613 16.648 1.0028.07 ATOM 2345 CA GLY H 44 18.254 -1.086 15.428 1.00 26.41 ATOM 2346 C GLY H 44 18.243 -2.166 14.329 1.00 22.61 ATOM 2347 O GLY H 44 18.060 -3.372 14.656 1.00 21.36 ATOM 2348 N LEU H 45 18.487 -1.765 13.052 1.00 18.78 ATOM 2350 CA LEUH 45 18.452 -2.735 11.913 1.00 14.74 ATOM 2351 CB LEUH 45 18.017 -2.075 10.586 1.00 10.90 ATOM 2352 CG LEUH 45 16.517 -1.769 10.423 1.00 7.35 ATOM 2353 CD1 LEUH 45 16.263 -1.084 9.109 1.00 8.68 ATOM 2354 CD2 LEU H 45 15.661 -3.020 10.517 1.00 4.89 ATOM 2355 C LEU H 45 19.768 -3.456 11.710 1.00 13.85 ATOM 2356 O LEUH 45 20.871 -2.869 11.727 1.00 11.97 ATOM 2357 N GLUH 46 19.674 -4.761 11.517 1.00 13.05 ATOM 2359 CA GLU H 46 20.873 -5.546 11.302 1.00 10.92 ATOM 2360 CB GLU H 46 21.260 -6.307 12.583 1.00 12.86 ATOM 2361 CG GLUH 46 22.733 -6.645 12.659 1.0021.14 ATOM 2362 CD GLU H 46 23.067 -7.738 13.653 1.00 24.52 ATOM 2363 OE1 GLU H 46 22.400 -7.816 14.716 1.00 28.63 ATOM 2364 OE2 GLU H 46 24.015 -8.510 13.375 1.00 25.36 ATOM 2365 C GLU H 46 20.648 -6.540 10.150 1.00 9.90 ATOM 2366 O GLU H 46 19.726 -7.366 10.196 1.00 6.95 ATOM 2367 N TRPH 47 21.476 -6.428 9.123 1.00 7.54 ATOM 2369 CA TRPH 47 21.355 -7.311 7.982 1.00 7.90 ATOM 2370 CB TRP H 47 22.064 -6.701 6.740 1.00 10.76 ATOM 2371 CG TRP H 47 22.169 -7.636 5.565 1.00 5.45 ATOM 2372 CD2 TRP H 47 23.313 -8.463 5.242 1.00 3.79 ATOM 2373 CE2TRPH 47 23.012 -9.172 4.083 1.00 2.00 ATOM 2374 CE3 TRP H 47 24.572 -8.670 5.845 1.00 3.96 ATOM 2375 CD1 TRP H 47 21.210 -7.873 4.602 1.00 4.22 ATOM 2376 NEl TRP H 47 21.740 -8.799 3.718 1.00 5.25 ATOM 2378 CZ2 TRPH 47 23.913 -10.066 3.502 1.00 2.56 ATOM 2379 CZ3 TRP H 47 25.451 -9.562 5.268 1.00 2.00 ATOM 2380 CH2 TRP H 47 25.116-10.235 4.110 1.00 2.00 ATOM 2381 C TRPH 47 21.937 -8.650 8.367 1.00 2.55 WO 99/10379 PCT/GB98/02542 -189 ATOM 2382 O TRP H 47 22.989 -8.736 8.994 1.00 5.06 ATOM 2383 N VAL H 48 21.234 -9.664 8.006 1.00 6.21 ATOM 2385 CA VAL H 48 21.553 -10.994 8.436 1.00 7.94 ATOM 2386 CB VAL H 48 20.271 -11.532 9.165 1.00 7.86 ATOM 2387 CGI VAL H 48 20.199-13.039 9.174 1.00 10.48 ATOM 2388 CG2 VAL H 48 20.244 -10.967 10.598 1.00 4.08 ATOM 2389 C VAL H 48 22.056-11.928 7.267 1.00 8.81 ATOM 2390 0 VAL H 48 23.101 -12.618 7.404 1.00 5.89 ATOM 2391 N ALAH 49 21.351-11.914 6.127 1.00 6.18 ATOM 2393 CA ALA H 49 21.700 -12.813 5.035 1.00 4.66 ATOM 2394 CB ALA H 49 21.208 -14.203 5.342 1.00 2.00 ATOM 2395 C ALA H 49 21.057 -12.384 3.736 1.00 5.58 ATOM 2396 O ALA H 49 20.010 -11.747 3.745 1.00 7.99 ATOM 2397 N GLU H 50 21.711 -12.787 2.620 1.00 7.04 ATOM 2399 CA GLU H 50 21.177 -12.560 1.275 1.00 8.25 ATOM 2400 CB GLU H 50 21.983 -11.507 0.518 1.00 9.60 ATOM 2401 CG GLU H 50 23.415 -11.900 0.271 1.00 7.83 ATOM 2402 CD GLUH 50 24.059-11.043 -0.762 1.00 13.01 ATOM 2403 OE1 GLUH 50 24.860-11.574 -1.536 1.00 9.53 ATOM 2404 OE2 GLU H 50 23.750 -9.830 -0.806 1.00 13.19 ATOM 2405 C GLU H 50 21.287 -13.872 0.493 1.00 6.87 ATOM 2406 O GLU H 50 22.120 -14.702 0.832 1.00 5.50 ATOM 2407 N ILE H 51 20.423 -14.049 -0.489 1.00 7.46 ATOM 2409 CA ILE H 51 20.525 -15.201 -1.407 1.00 6.66 ATOM 2410 CB ILEH 51 19.542-16.318 -1.060 1.00 3.45 ATOM 2411 CG2ILEH 51 18.094-15.845 -1.218 1.00 9.97 ATOM 2412 CG1 ILEH 51 19.820-17.559 -1.892 1.00 2.00 ATOM 2413 CD ILEH 51 18.849-18.673 -1.582 1.00 2.00 ATOM 2414 C ILE H 51 20.265-14.716 -2.841 1.00 5.59 ATOM 2415 O ILEH 51 19.323-13.991 -3.108 1.00 5.07 ATOM 2416 N ARGH 52 21.116-15.123 -3.745 1.00 6.35 ATOM 2418 CA ARG H 52 21.016-14.633 -5.108 1.00 8.96 ATOM 2419 CB ARG H 52 22.421 -14.501 -5.684 1.00 5.72 ATOM 2420 CG ARG H 52 23.496-14.350 -4.591 1.00 12.48 ATOM 2421 CD ARG H 52 24.049 -12.963 -4.426 1.00 13.83 ATOM 2422 NE ARG H 52 25.266 -12.784 -5.163 1.00 12.25 ATOM 2424 CZ ARG H 52 26.261 -11.942 -4.831 1.00 12.96 ATOM 2425 NH1 ARG H 52 27.292 -11.867 -5.607 1.00 11.49 ATOM 2428 NH2 ARG H 52 26.235 -11.166 -3.765 1.00 14.67 ATOM 2431 C ARG H 52 20.091 -15.492 -5.959 1.00 10.32 ATOM 2432 O ARGH 52 19.256-16.204 -5.416 1.00 8.96 ATOM 2433 N LEUH 52A 20.247-15.437 -7.310 1.00 9.13 ATOM 2435 CA LEU H 52A 19.293 -16.088 -8.198 1.00 9.35 ATOM 2436 CB LEU H 52A 19.218 -15.294 -9.498 1.00 8.23 ATOM 2437 CG LEU H 52A 19.030 -13.759 -9.350 1.00 4.43 ATOM 2438 CD1 LEU H 52A 19.087 -13.099 -10.721 1.00 9.87 ATOM 2439 CD2 LEU H 52A 17.701 -13.450 -8.694 1.00 4.72 ATOM 2440 C LEU H 52A 19.642 -17.538 -8.507 1.00 6.27 ATOM 2441 O LEU H 52A 20.735 -18.003 -8.227 1.00 6.95 ATOM 2442 N LYS H 52B 18.707 -18.240 -9.087 1.00 7.45 ATOM 2444 CA LYS H 52B 19.002 -19.570 -9.564 1.00 11.04 ATOM 2445 CB LYS H 52B 17.851 -20.082 -10.394 1.00 13.40 ATOM 2446 CG LYS H 52B 18.080 -21.505 -10.842 1.00 18.86 ATOM 2447 CD LYS H 52B 16.950 -22.008 -11.699 1.00 21.41 ATOM 2448 CE LYS H 52B 17.363 -23.307 -12.408 1.00 27.85 ATOM 2449 NZ LYS H 52B 16.327 -23.728 -13.385 1.00 34.07 ATOM 2453 C LYSH 52B 20.277-19.571 -10.407 1.00 11.82 ATOM 2454 O LYS H 52B 21.175 -20.365 -10.168 1.00 10.65 ATOM 2455 N SERH 52C 20.364-18.627-11.377 1.00 10.14 ATOM 2457 CA SERH 52C 21.522-18.520-12.231 1.00 8.75 ATOM 2458 CB SER H 52C 21.276 -17.513 -13.352 1.00 11.63 ATOM 2459 OG SERH 52C 20.872-16.286-12.838 1.00 15.43 ATOM 2461 C SERH 52C 22.788-18.173-11.499 1.00 11.06 ATOM 2462 O SERH 52C 23.851 -18.241 -12.089 1.00 9.23 ATOM 2463 N ASN H 53 22.694 -17.799 -10.197 1.00 10.74 ATOM 2465 CA ASN H 53 23.902-17.544 -9.381 1.00 11.27 ATOM 2466 CB ASN H 53 23.666-16.359 -8.458 1.00 10.94 ATOM 2467 CG ASN H 53 23.335 -15.136 -9.252 1.00 8.42 ATOM 2468 ODI ASN H 53 22.251 -14.580 -9.150 1.00 12.13 ATOM 2469 ND2 ASN H 53 24.262 -14.729 -10.060 1.00 10.17 ATOM 2472 C ASN H 53 24.216 -18.790 -8.543 1.00 10.33 ATOM 2473 O ASN H 53 25.160 -18.808 -7.705 1.00 9.92 WO 99/10379 PCT/GB98/02542 -190 ATOM 2474 N ASN H 54 23.439 -19.852 -8.826 1.00 10.20 ATOM 2476 CA ASN H 54 23.551 -21.163 -8.120 1.00 10.20 ATOM 2477 CB ASN H 54 25.011 -21.606 -7.986 1.00 6.42 ATOM 2478 CG ASN H 54 25.726 -21.683 -9.341 1.00 8.73 ATOM 2479 ODI ASNH 54 25.244-22.312-10.274 1.00 8.04 ATOM 2480 ND2 ASN H 54 26.858 -21.024 -9.453 1.00 4.73 ATOM 2483 C ASN H 54 22.950 -21.062 -6.718 1.00 11.89 ATOM 2484 O ASN H 54 23.297 -21.860 -5.839 1.00 12.26 ATOM 2485 N TYR H 55 22.046-20.090 -6.524 1.00 9.38 ATOM 2487 CA TYRH 55 21.484-19.806 -5.175 1.00 8.46 ATOM 2488 CB TYR H 55 20.698 -21.003 -4.697 1.00 2.42 ATOM 2489 CG TYRH 55 19.528 -21.295 -5.577 1.00 8.11 ATOM 2490 CDI TYRH 55 19.514-22.432 -6.404 1.00 9.49 ATOM 2491 CEI TYRH 55 18.407-22.701 -7.215 1.00 12.87 ATOM 2492 CD2 TYR H 55 18.427 -20.461 -5.589 1.00 4.03 ATOM 2493 CE2 TYR H 55 17.335 -20.717 -6.381 1.00 11.68 ATOM 2494 CZ TYRH 55 17.325 -21.845 -7.207 1.00 15.91 ATOM 2495 OH TYR H 55 16.234 -22.076 -8.070 1.00 20.99 ATOM 2497 C TYRH 55 22.609-19.434 -4.168 1.00 8.90 ATOM 2498 O TYRH 55 22.572-19.819 -2.968 1.00 12.11 ATOM 2499 N ALA H 56 23.598 -18.646 -4.647 1.00 5.77 ATOM 2501 CA ALA H 56 24.707 -18.204 -3.818 1.00 7.06 ATOM 2502 CB ALAH 56 25.729-17.514 -4.713 1.00 11.84 ATOM 2503 C ALA H 56 24.215 -17.266 -2.660 1.00 7.10 ATOM 2504 O ALA H 56 23.166 -16.609 -2.757 1.00 5.63 ATOM 2505 N THRH 57 24.970-17.229 -1.566 1.00 7.85 ATOM 2507 CA THRH 57 24.513 -16.532 -0.373 1.00 6.03 ATOM 2508 CB THRH 57 23.978-17.545 0.679 1.00 4.33 ATOM 2509 OGI THRH 57 25.028-18.473 1.037 1.00 3.89 ATOM 2511 CG2THRH 57 22.769-18.316 0.163 1.00 3.87 ATOM 2512 C THRH 57 25.632-15.814 0.287 1.00 4.64 ATOM 2513 O THRH 57 26.812-16.091 0.021 1.00 7.15 ATOM 2514 N HIS H 58 25.284-14.850 1.141 1.00 5.83 ATOM 2516 CA HIS H 58 26.293 -14.231 2.021 1.00 2.00 ATOM 2517 CB HISH 58 26.921 -12.931 1.497 1.00 4.50 ATOM 2518 CG HIS H 58 27.572 -13.120 0.170 1.00 4.63 ATOM 2519 CD2 HIS H 58 28.846-13.287 -0.205 1.00 7.27 ATOM 2520 NDI HIS H 58 26.845 -13.170 -0.966 1.00 5.48 ATOM 2522 CEl HISH 58 27.570-13.365 -2.011 1.00 8.70 ATOM 2523 NE2 HIS H 58 28.800 -13.435 -1.577 1.00 9.97 ATOM 2525 C HIS H 58 25.601 -13.989 3.345 1.00 2.00 ATOM 2526 O HIS H 58 24.381 -13.898 3.362 1.00 2.00 ATOM 2527 N TYRH 59 26.384-13.961 4.399 1.00 3.87 ATOM 2529 CA TYR H 59 25.864 -13.906 5.777 1.00 6.14 ATOM 2530 CB TYRH 59 26.107 -15.252 6.467 1.00 4.65 ATOM 2531 CG TYRH 59 25.271 -16.347 5.898 1.00 2.93 ATOM 2532 CD1 TYRH 59 25.758-17.152 4.887 1.00 7.71 ATOM 2533 CE1 TYRH 59 24.947-18.093 4.278 1.00 5.29 ATOM 2534 CD2TYRH 59 23.946-16.515 6.295 1.00 4.20 ATOM 2535 CE2TYRH 59 23.149-17.452 5.690 1.00 5.04 ATOM 2536 CZ TYRH 59 23.678-18.232 4.673 1.00 5.90 ATOM 2537 OH TYRH 59 22.939-19.182 4.123 1.00 9.69 ATOM 2539 C TYRH 59 26.594-12.892 6.574 1.00 6.82 ATOM 2540 O TYRH 59 27.761 -12.666 6.335 1.00 7.72 ATOM 2541 N ALAH 60 25.931 -12.299 7.550 1.00 8.95 ATOM 2543 CA ALA H 60 26.650 -11.388 8.438 1.00 6.79 ATOM 2544 CB ALA H 60 25.673 -10.579 9.283 1.00 8.53 ATOM 2545 C ALA H 60 27.503 -12.219 9.336 1.00 10.22 ATOM 2546 O ALAH 60 27.113 -13.351 9.701 1.00 11.26 ATOM 2547 N ALAH 61 28.650-11.676 9.743 1.00 13.53 ATOM 2549 CA ALA H 61 29.577-12.429 10.584 1.00 14.91 ATOM 2550 CB ALAH 61 30.802-11.573 10.930 1.00 14.40 ATOM 2551 C ALAH 61 28.908-12.963 11.864 1.0017.24 ATOM 2552 O ALA H 61 29.237-14.047 12.320 1.0021.67 ATOM 2553 N SERH 62 27.932-12.239 12.405 1.00 18.88 ATOM 2555 CA SERH 62 27.306 -12.631 13.682 1.00 20.00 ATOM 2556 CB SERH 62 26.509-11.457 14.200 1.00 16.39 ATOM 2557 OG SERH 62 25.622-10.968 13.202 1.00 18.61 ATOM 2559 C SERH 62 26.370 -13.836 13.548 1.0021.12 ATOM 2560 O SERH 62 25.769-14.313 14.527 1.00 19.05 ATOM 2561 N VAL H 63 26.256 -14.333 12.352 1.00 18.08 ATOM 2563 CA VALH 63 25.250-15.311 12.067 1.00 17.68 WO 99/10379 PCT/GB98/02542 -191 ATOM 2564 CB VAL H 63 24.137 -14.526 11.349 1.00 18.65 ATOM 2565 CG1 VAL H 63 23.649 -15.184 10.084 1.00 16.99 ATOM 2566 CG2 VAL H 63 23.022 -14.241 12.351 1.00 12.88 ATOM 2567 C VAL H 63 25.837 -16.469 11.264 1.00 15.76 ATOM 2568 0 VAL H 63 25.280 -17.560 11.194 1.00 14.97 ATOM 2569 N LYS H 64 27.015 -16.231 10.750 1.00 18.14 ATOM 2571 CA LYS H 64 27.685 -17.200 9.940 1.0020.28 ATOM 2572 CB LYS H 64 29.060 -16.647 9.528 1.0022.43 ATOM 2573 CG LYS H 64 29.192 -16.198 8.089 1.0020.56 ATOM 2574 CD LYS H 64 30.621 -15.730 7.833 1.0023.16 ATOM 2575 CE LYS H 64 30.812 -15.238 6.413 0.01 21.98 ATOM 2576 NZ LYS H 64 32.230 -14.876 6.134 0.01 23.60 ATOM 2580 C LYS H 64 27.845 -18.489 10.730 1.00 18.78 ATOM 2581 O LYSH 64 28.206-18.455 11.907 1.0020.26 ATOM 2582 N GLY H 65 27.545 -19.606 10.084 1.00 17.68 ATOM 2584 CA GLY H 65 27.676 -20.907 10.732 1.00 16.07 ATOM 2585 C GLYH 65 26.461 -21.337 11.563 1.00 14.30 ATOM 2586 O GLY H 65 26.362 -22.497 11.930 1.00 14.97 ATOM 2587 N ARG H 66 25.536-20.421 11.858 1.00 14.24 ATOM 2589 CA ARG H 66 24.324 -20.777 12.607 1.00 10.28 ATOM 2590 CB ARG H 66 24.245 -19.925 13.845 1.00 7.89 ATOM 2591 CG ARG H 66 25.480 -20.014 14.692 1.00 7.93 ATOM 2592 CD ARG H 66 25.663 -18.698 15.446 1.00 14.73 ATOM 2593 NE ARG H 66 24.524 -18.447 16.242 1.00 17.33 ATOM 2595 CZ ARG H 66 23.908 -17.292 16.364 1.00 17.22 ATOM 2596 NHI ARG H 66 22.878 -17.269 17.125 1.00 18.44 ATOM 2599 NI-12 ARG H 66 24.306 -16.173 15.772 1.00 15.39 ATOM 2602 C ARG H 66 23.078 -20.588 11.793 1.00 9.54 ATOM 2603 O ARG H 66 22.054-21.264 12.017 1.00 11.68 ATOM 2604 N PHE H 67 23.098 -19.625 10.874 1.00 9.08 ATOM 2606 CA PHEH 67 21.902-19.383 10.053 1.00 8.27 ATOM 2607 CB PHE H 67 21.489 -17.883 10.070 1.00 14.66 ATOM 2608 CG PHE H 67 20.947 -17.325 11.376 1.00 11.27 ATOM 2609 CD1 PHEH 67 20.920-18.097 12.555 1.00 16.10 ATOM 2610 CD2 PHE H 67 20.467 -16.026 11.430 1.00 12.21 ATOM 2611 CE1 PHEH 67 20.433 -17.564 13.746 1.00 15.15 ATOM 2612 CE2 PHE H 67 19.982-15.490 12.625 1.00 16.05 ATOM 2613 CZ PHEH 67 19.968-16.259 13.774 1.00 14.19 ATOM 2614 C PHEH 67 22.159-19.801 8.590 1.00 8.04 ATOM 2615 O PHEH 67 23.317-19.732 8.113 1.00 7.14 ATOM 2616 N THRH 68 21.076-20.208 7.898 1.00 5.55 ATOM 2618 CA THRH 68 21.144-20.637 6.500 1.00 6.31 ATOM 2619 CB THRH 68 21.151 -22.179 6.428 1.00 10.66 ATOM 2620 OG1 THRH 68 22.306-22.665 7.128 1.00 8.86 ATOM 2622 CG2 THRH 68 21.133 -22.687 4.978 1.00 10.19 ATOM 2623 C THRH 68 19.917-20.126 5.738 1.00 6.07 ATOM 2624 O THRH 68 18.767 -20.466 6.071 1.00 9.45 ATOM 2625 N ILEH 69 20.141 -19.270 4.750 1.00 4.87 ATOM 2627 CA ILEH 69 19.049-18.764 3.958 1.00 2.00 ATOM 2628 CB ILE H 69 19.310-17.256 3.524 1.00 6.99 ATOM 2629 CG2 ILE H 69 20.538 -17.123 2.645 1.00 7.03 ATOM 2630 CG1 ILE H 69 18.097 -16.669 2.798 1.00 2.00 ATOM 2631 CD ILEH 69 18.320-15.236 2.400 1.00 2.00 ATOM 2632 C ILEH 69 18.897-19.669 2.718 1.00 2.51 ATOM 2633 O ILEH 69 19.876-20.196 2.252 1.00 2.38 ATOM 2634 N SER H 70 17.680 -19.873 2.253 1.00 2.57 ATOM 2636 CA SERH 70 17.469 -20.669 1.076 1.00 6.14 ATOM 2637 CB SERH 70 17.380 -22.175 1.448 1.00 9.52 ATOM 2638 OG SERH 70 16.268 -22.503 2.279 1.00 10.39 ATOM 2640 C SER H 70 16.207 -20.196 0.385 1.00 6.48 ATOM 2641 O SERH 70 15.460-19.431 0.959 1.00 7.77 ATOM 2642 N ARG H 71 15.973 -20.612 -0.858 1.00 7.82 ATOM 2644 CA ARG H 71 14.761-20.181 -1.550 1.00 8.16 ATOM 2645 CB ARG H 71 15.000 -18.914 -2.446 1.00 10.92 ATOM 2646 CG ARGH 71 15.996-19.087 -3.614 1.00 8.76 ATOM 2647 CD ARG H 71 16.362-17.741 -4.294 1.00 4.61 ATOM 2648 NE ARG H 71 15.191 -17.036 -4.849 1.00 7.09 ATOM 2650 CZ ARG H 71 15.228 -15.735 -5.189 1.00 7.29 ATOM 2651 NHI ARGH 71 14.156-15.124 -5.665 1.00 8.76 ATOM 2654 NH2ARGH 71 16.331 -15.058 -5.011 1.00 3.13 ATOM 2657 C ARG H 71 14.174 -21.274 -2.383 1.00 9.04 ATOM 2658 O ARG H 71 14.844-22.180 -2.800 1.00 11.10 WO 99/10379 PCT/GB98/02542 -192 ATOM 2659 N ASP H 72 12.918 -21.163 -2.626 1.00 8.40 ATOM 2661 CA ASP H 72 12.289 -22.068 -3.482 1.00 13.86 ATOM 2662 CB ASP H 72 11.481 -23.065 -2.666 1.00 18.00 ATOM 2663 CG ASPH 72 10.864-24.131 -3.538 1.0022.29 ATOM 2664 ODI ASP H 72 9.974 -23.794 -4.325 1.00 18.82 ATOM 2665 OD2 ASP H 72 11.258-25.307 -3.419 1.00 29.08 ATOM 2666 C ASP H 72 11.420-21.246 -4.406 1.00 12.87 ATOM 2667 O ASP H 72 10.344-20.782 -4.047 1.00 11.56 ATOM 2668 N ASP H 73 11.919-21.035 -5.587 1.00 14.62 ATOM 2670 CA ASP H 73 11.199-20.236 -6.513 1.00 12.47 ATOM 2671 CB ASP H 73 12.041 -19.914 -7.757 1.00 14.32 ATOM 2672 CG ASP H 73 13.310 -19.140 -7.394 1.00 12.44 ATOM 2673 ODI ASP H 73 13.277 -18.373 -6.416 1.00 13.98 ATOM 2674 OD2 ASP H 73 14.341 -19.316 -8.059 1.00 14.38 ATOM 2675 C ASPH 73 9.931 -20.899 -6.869 1.00 15.39 ATOM 2676 O ASPH 73 8.975-20.159 -7.118 1.00 17.19 ATOM 2677 N SERH 74 9.856-22.293 -6.824 1.00 16.30 ATOM 2679 CA SERH 74 8.538-22.984 -7.156 1.00 17.45 ATOM 2680 CB SER H 74 8.532 -24.599 -7.050 1.00 15.19 ATOM 2681 OG SER H 74 9.312 -25.282 -6.029 1.00 2.00 ATOM 2683 C SERH 74 7.418-22.406 -6.305 1.00 19.15 ATOM 2684 O SER H 74 6.276 -22.222 -6.769 1.00 16.07 ATOM 2685 N LYS H 75 7.797 -22.022 -5.063 1.00 20.59 ATOM 2687 CA LYS H 75 6.840 -21.532 -4.071 1.00 22.07 ATOM 2688 CB LYS H 75 7.137 -22.236 -2.744 1.0022.73 ATOM 2689 CG LYS H 75 7.181 -23.747 -2.878 1.00 30.86 ATOM 2690 CD LYS H 75 8.082 -24.387 -1.825 1.00 34.56 ATOM 2691 CE LYSH 75 7.988 -25.896 -1.899 1.0036.81 ATOM 2692 NZ LYS H 75 6.598 -26.374 -1.597 1.00 38.63 ATOM 2696 C LYS H 75 6.880 -20.022 -3.865 1.00 21.01 ATOM 2697 O LYS H 75 6.121 -19.481 -3.032 1.00 18.31 ATOM 2698 N SERH 76 7.737-19.329 -4.598 1.00 18.64 ATOM 2700 CA SERH 76 7.852-17.876 -4.417 1.00 16.65 ATOM 2701 CB SERH 76 6.539-17.182 -4.738 1.00 18.03 ATOM 2702 OG SERH 76 6.413 -16.873 -6.103 1.0023.00 ATOM 2704 C SERH 76 8.154-17.593 -2.969 1.00 15.08 ATOM 2705 O SER H 76 7.553 -16.704 -2.411 1.00 13.71 ATOM 2706 N SERH 77 9.089-18.353 -2.376 1.00 12.40 ATOM 2708 CA SER H 77 9.333 -18.222 -0.957 1.00 11.32 ATOM 2709 CB SER H 77 8.666 -19.385 -0.235 1.00 5.62 ATOM 2710 OG SERH 77 7.244-19.338 -0.349 1.00 11.83 ATOM 2712 C SERH 77 10.801 -18.209 -0.653 1.00 11.23 ATOM 2713 O SERH 77 11.586-18.826 -1.386 1.00 10.52 ATOM 2714 N VALH 78 11.178-17.438 0.380 1.00 11.36 ATOM 2716 CA VAL H 78 12.557 -17.449 0.908 1.00 9.82 ATOM 2717 CB VALH 78 13.284-16.055 0.778 1.00 2.05 ATOM 2718 CG1 VAL H 78 12.638 -15.004 1.613 1.00 8.95 ATOM 2719 CG2VALH 78 14.736-16.175 1.126 1.00 6.47 ATOM 2720 C VAL H 78 12.439 -17.924 2.378 1.00 10.77 ATOM 2721 0 VALH 78 11.339-17.884 2.943 1.00 10.22 ATOM 2722 N TYRH 79 13.510-18.447 2.962 1.00 9.85 ATOM 2724 CA TYRH 79 13.401 -19.059 4.298 1.00 11.42 ATOM 2725 CB TYR H 79 13.279 -20.578 4.167 1.00 8.95 ATOM 2726 CG TYRH 79 12.223 -21.091 3.208 1.00 9.83 ATOM 2727 CDI TYRH 79 10.890-21.229 3.592 1.00 13.08 ATOM 2728 CEl TYRH 79 9.939-21.770 2.734 1.00 13.31 ATOM 2729 CD2 TYR H 79 12.569 -21.502 1.923 1.00 16.54 ATOM 2730 CE2TYRH 79 11.640-22.047 1.060 1.00 13.14 ATOM 2731 CZ TYRH 79 10.327-22.194 1.470 1.00 15.87 ATOM 2732 OH TYRH 79 9.436-22.916 0.674 1.0021.63 ATOM 2734 C TYRH 79 14.652-18.789 5.081 1.00 8.87 ATOM 2735 O TYRH 79 15.679-18.519 4.485 1.00 7.96 ATOM 2736 N LEUH 80 14.561 -18.851 6.418 1.00 7.68 ATOM 2738 CA LEU H 80 15.758 -18.726 7.275 1.00 6.13 ATOM 2739 CB LEU H 80 15.864 -17.318 7.922 1.00 3.75 ATOM 2740 CG LEU H 80 17.142 -17.034 8.797 1.00 5.89 ATOM 2741 CDI LEU H 80 18.360 -16.802 7.906 1.00 7.66 ATOM 2742 CD2 LEU H 80 16.934 -15.797 9.679 1.00 7.64 ATOM 2743 C LEUH 80 15.721 -19.813 8.388 1.00 6.11 ATOM 2744 O LEUH 80 14.831-19.837 9.212 1.00 10.81 ATOM 2745 N GLN H 81 16.662 -20.692 8.332 1.00 9.34 ATOM 2747 CA GLNH 81 16.836-21.742 9.294 1.00 7.35 WO 99/10379 PCT/GB98/02542 -193 ATOM 2748 CB GLN H 81 17.458 -22.950 8.601 1.00 10.80 ATOM 2749 CG GLN H 81 17.874 -24.108 9.496 1.00 7.67 ATOM 2750 CD GLN H 81 16.703 -24.581 10.254 1.00 12.30 ATOM 2751 OEl GLN H 81 15.676-24.859 9.669 1.00 9.50 ATOM 2752 NE2 GLN H 81 16.824 -24.628 11.577 1.00 14.89 ATOM 2755 C GLN H 81 17.772 -21.246 10.299 1.00 7.63 ATOM 2756 O GLN H 81 18.925 -20.973 9.982 1.00 6.37 ATOM 2757 N METH 82 17.327-21.119 11.526 1.00 8.18 ATOM 2759 CA METH 82 18.231 -20.598 12.573 1.00 8.53 ATOM 2760 CB MET H 82 17.574-19.407 13.273 1.00 11.01 ATOM 2761 CG MET H 82 17.021 -18.404 12.305 1.00 12.29 ATOM 2762 SD METH 82 15.941 -17.230 13.061 1.00 13.74 ATOM 2763 CE MET H 82 14.457-18.124 12.844 1.00 14.37 ATOM 2764 C MET H 82 18.512-21.687 13.592 1.00 8.43 ATOM 2765 O MET H 82 17.574-22.300 14.079 1.00 5.71 ATOM 2766 N ASN H 82A 19.784 -21.874 13.889 1.00 8.95 ATOM 2768 CA ASN H 82A 20.240 -22.876 14.802 1.00 11.83 ATOM 2769 CB ASNH 82A 21.152-23.871 14.094 1.00 14.31 ATOM 2770 CG ASN H 82A 20.435 -24.642 13.030 1.00 14.14 ATOM 2771 OD1 ASN H 82A 19.202 -24.697 13.022 1.00 20.53 ATOM 2772 ND2 ASN H 82A 21.186 -25.207 12.109 1.00 19.33 ATOM 2775 C ASN H 82A 21.062 -22.227 15.874 1.00 14.07 ATOM 2776 O ASNH 82A 21.560-21.114 15.685 1.00 12.90 ATOM 2777 N ASN H 82B 21.232 -22.938 16.971 1.00 13.76 ATOM 2779 CA ASN H 82B 22.088 -22.462 18.073 1.00 17.95 ATOM 2780 CB ASN H 82B 23.590 -22.671 17.708 1.00 20.73 ATOM 2781 CG ASN H 82B 23.871 -24.023 16.988 1.0029.83 ATOM 2782 OD1 ASN H 82B 23.782 -25.129 17.563 1.00 32.41 ATOM 2783 ND2 ASN H 82B 24.219-23.953 15.704 1.00 33.10 ATOM 2786 C ASNH 82B 21.759-20.982 18.397 1.00 15.91 ATOM 2787 O ASN H 82B 22.633 -20.118 18.520 1.00 12.49 ATOM 2788 N LEU H 82C 20.445 -20.717 18.497 1.00 14.84 ATOM 2790 CA LEUH 82C 19.944-19.382 18.758 1.00 13.25 ATOM 2791 CB LEUH 82C 18.409-19.392 18.668 1.00 7.42 ATOM 2792 CG LEU H 82C 17.787 -19.362 17.248 1.00 7.73 ATOM 2793 CD1 LEU H 82C 16.312-19.737 17.258 1.00 4.66 ATOM 2794 CD2 LEUH 82C 17.920-17.971 16.669 1.00 2.94 ATOM 2795 C LEUH 82C 20.473 -18.838 20.110 1.00 16.15 ATOM 2796 O LEU H 82C 20.775 -19.596 21.050 1.00 17.22 ATOM 2797 N ARG H 83 20.641 -17.525 20.163 1.00 16.23 ATOM 2799 CA ARGH 83 21.147-16.838 21.318 1.00 16.47 ATOM 2800 CB ARG H 83 22.474 -16.221 21.000 1.00 17.57 ATOM 2801 CG ARG H 83 23.503 -17.159 20.472 1.0023.38 ATOM 2802 CD ARG H 83 24.656 -16.319 19.994 1.0029.30 ATOM 2803 NE ARG H 83 25.722 -17.091 19.407 1.00 30.53 ATOM 2805 CZ ARG H 83 26.685 -16.527 18.696 1.00 33.66 ATOM 2806 NH1 ARG H 83 27.658 -17.280 18.201 1.00 37.56 ATOM 2809 NH2 ARG H 83 26.680 -15.199 18.477 1.00 35.33 ATOM 2812 C ARG H 83 20.185-15.715 21.668 1.00 17.82 ATOM 2813 O ARG H 83 19.461 -15.226 20.798 1.00 19.55 ATOM 2814 N ALA H 84 20.185 -15.255 22.900 1.00 14.91 ATOM 2816 CA ALA H 84 19.254 -14.173 23.249 1.00 16.48 ATOM 2817 CB ALA H 84 19.366 -13.837 24.723 1.00 15.35 ATOM 2818 C ALA H 84 19.493 -12.909 22.384 1.00 14.44 ATOM 2819 O ALA H 84 18.559-12.129 22.125 1.00 16.17 ATOM 2820 N ALA H 85 20.748 -12.735 21.929 1.00 15.72 ATOM 2822 CA ALAH 85 21.104-11.596 21.076 1.00 15.91 ATOM 2823 CB ALA H 85 22.628 -11.499 20.932 1.00 11.61 ATOM 2824 C ALA H 85 20.433 -11.691 19.678 1.00 15.42 ATOM 2825 O ALA H 85 20.438 -10.694 18.921 1.00 14.28 ATOM 2826 N ASP H 86 19.877-12.880 19.335 1.00 12.78 ATOM 2828 CA ASP H 86 19.172 -13.064 18.045 1.00 10.42 ATOM 2829 CB ASP H 86 19.198-14.509 17.571 1.00 4.96 ATOM 2830 CG ASP H 86 20.590-15.028 17.411 1.00 10.01 ATOM 2831 ODI ASPH 86 20.820-16.182 17.780 1.00 12.26 ATOM 2832 OD2 ASP H 86 21.453 -14.293 16.934 1.00 8.11 ATOM 2833 C ASPH 86 17.739-12.640 18.142 1.00 8.78 ATOM 2834 O ASP H 86 16.999-12.683 17.168 1.00 12.52 ATOM 2835 N THRH 87 17.331-12.241 19.311 1.00 8.30 ATOM 2837 CA THRH 87 15.957-11.796 19.500 1.00 8.21 ATOM 2838 CB THRH 87 15.706-11.463 21.037 1.00 7.33 ATOM 2839 OGI THRH 87 15.888-12.655 21.802 1.00 6.98 WO 99/10379 PCT/GB98/02542 -194 ATOM 2841 CG2THRH 87 14.304-10.960 21.286 1.00 5.67 ATOM 2842 C THR H 87 15.687 -10.575 18.603 1.00 9.42 ATOM 2843 O THRH 87 16.557 -9.719 18.446 1.00 13.23 ATOM 2844 N GLY H 88 14.533 -10.533 17.980 1.00 7.71 ATOM 2846 CA GLY H 88 14.193 -9.374 17.192 1.00 9.10 ATOM 2847 C GLYH 88 13.113 -9.691 16.243 1.00 9.84 ATOM 2848 O GLY H 88 12.644 -10.824 16.234 1.00 7.86 ATOM 2849 N ILE H 89 12.655 -8.677 15.485 1.00 9.11 ATOM 2851 CA ILEH 89 11.644 -8.885 14.456 1.00 10.31 ATOM 2852 CB ILEH 89 10.781 -7.639 14.300 1.00 11.02 ATOM 2853 CG2 ILE H 89 9.724 -7.873 13.233 1.00 10.51 ATOM 2854 CG1 ILE H 89 10.139 -7.330 15.659 1.00 11.28 ATOM 2855 CD ILE H 89 9.284 -6.073 15.682 1.00 17.09 ATOM 2856 C ILEH 89 12.385 -9.170 13.146 1.00 11.03 ATOM 2857 O ILEH 89 13.322 -8.442 12.807 1.00 11.03 ATOM 2858 N TYRH 90 12.039-10.285 12.488 1.00 11.24 ATOM 2860 CA TYRH 90 12.742-10.687 11.281 1.00 9.58 ATOM 2861 CB TYRH 90 13.136-12.141 11.351 1.00 4.73 ATOM 2862 CG TYRH 90 14.348-12.417 12.227 1.00 4.17 ATOM 2863 CDI TYRH 90 14.286-12.296 13.633 1.00 2.00 ATOM 2864 CE1 TYRH 90 15.385-12.594 14.426 1.00 2.00 ATOM 2865 CD2TYRH 90 15.539-12.851 11.669 1.00 2.40 ATOM 2866 CE2TYRH 90 16.635-13.147 12.465 1.00 2.17 ATOM 2867 CZ TYRH 90 16.544-13.008 13.855 1.00 2.00 ATOM 2868 OH TYRH 90 17.665 -13.223 14.644 1.00 2.45 ATOM 2870 C TYRH 90 11.923 -10.416 10.062 1.00 9.22 ATOM 2871 O TYRH 90 10.740-10.839 9.964 1.00 12.19 ATOM 2872 N TYRH 91 12.547 -9.679 9.131 1.00 8.92 ATOM 2874 CA TYRH 91 11.874 -9.271 7.878 1.00 6.94 ATOM 2875 CB TYRH 91 11.967 -7.735 7.705 1.00 8.51 ATOM 2876 CG TYRH 91 11.498 -6.910 8.859 1.00 7.13 ATOM 2877 CDI TYRH 91 10.185 -6.466 8.912 1.00 6.14 ATOM 2878 CEI TYRH 91 9.718 -5.698 9.980 1.00 7.31 ATOM 2879 CD2TYRH 91 12.358 -6.571 9.896 1.00 4.90 ATOM 2880 CE2 TYR H 91 11.889 -5.806 10.981 1.00 8.04 ATOM 2881 CZ TYRH 91 10.566 -5.379 11.012 1.00 5.99 ATOM 2882 OH TYRH 91 10.080 -4.630 12.114 1.00 13.80 ATOM 2884 C TYRH 91 12.588 -9.873 6.643 1.00 5.68 ATOM 2885 O TYRH 91 13.811 -9.911 6.613 1.00 10.68 ATOM 2886 N CYS H 92 11.858-10.371 5.667 1.00 5.92 ATOM 2888 CA CYS H 92 12.504 -10.601 4.362 1.00 9.62 ATOM 2889 CB CYS H 92 11.878-11.758 3.625 1.00 8.20 ATOM 2890 SG CYS H 92 10.133 -11.548 3.675 1.00 16.35 ATOM 2891 C CYS H 92 12.266 -9.322 3.536 1.00 7.60 ATOM 2892 O CYS H 92 11.183 -8.723 3.585 1.00 8.00 ATOM 2893 N THRH 93 13.239 -8.913 2.792 1.00 8.87 ATOM 2895 CA THRH 93 13.129 -7.658 2.043 1.00 9.75 ATOM 2896 CB THRH 93 13.594 -6.438 2.916 1.00 7.13 ATOM 2897 OG1 THRH 93 13.882 -5.296 2.069 1.00 8.11 ATOM 2899 CG2THRH 93 14.829 -6.781 3.713 1.00 6.38 ATOM 2900 C THRH 93 13.999 -7.733 0.801 1.00 9.01 ATOM 2901 O THRH 93 15.047 -8.368 0.860 1.00 8.92 ATOM 2902 N GLYH 94 13.576 -7.103 -0.311 1.00 8.19 ATOM 2904 CA GLY H 94 14.410 -7.128 -1.482 1.00 9.97 ATOM 2905 C GLY H 94 13.978 -6.140 -2.538 1.00 11.34 ATOM 2906 O GLY H 94 13.075 -5.369 -2.322 1.00 8.22 ATOM 2907 N VAL H 95 14.692 -6.178 -3.672 1.00 13.48 ATOM 2909 CA VAL H 95 14.458 -5.332 -4.849 1.00 10.59 ATOM 2910 CB VALH 95 13.011 -5.255 -5.260 1.00 9.92 ATOM 2911 CG1 VAL H 95 12.943 -4.461 -6.543 1.00 12.93 ATOM 2912 CG2 VAL H 95 12.405 -6.638 -5.477 1.00 12.57 ATOM 2913 C VALH 95 14.999 -3.909 -4.732 1.00 12.91 ATOM 2914 0 VALH 95 14.430 -3.040 -4.058 1.00 16.60 ATOM 2915 N GLYH 96 16.114 -3.704 -5.374 1.00 14.72 ATOM 2917 CA GLYH 96 16.735 -2.365 -5.516 1.00 17.50 ATOM 2918 C GLY H 96 16.907 -1.394 -4.292 1.00 15.41 ATOM 2919 O GLY H 96 16.437 -0.244 -4.355 1.00 16.20 ATOM 2920 N GLN H 97 17.519 -1.780 -3.174 1.00 13.46 ATOM 2922 CA GLNH 97 17.941 -3.130 -2.865 1.00 13.51 ATOM 2923 CB GLN H 97 19.422 -3.160 -2.463 1.00 11.95 ATOM 2924 CG GLN H 97 20.404 -3.131 -3.631 1.00 15.05 ATOM 2925 CD GLN H 97 20.374 -1.861 -4.476 1.00 16.43 WO 99/10379 PCT/GB98/02542 -195 ATOM 2926 OEI GLN H 97 20.856 -0.810 -4.064 1.00 17.08 ATOM 2927 NE2 GLN H 97 19.826 -1.965 -5.675 1.00 18.31 ATOM 2930 C GLN H 97 17.071 -3.627 -1.687 1.00 10.81 ATOM 2931 O GLN H 97 17.133 -4.792 -1.295 1.00 8.86 ATOM 2932 N PHE H 98 16.232 -2.733 -1.171 1.00 8.60 ATOM 2934 CA PHE H 98 15.370 -3.030 -0.030 1.00 8.66 ATOM 2935 CB PHE H 98 16.036 -2.546 1.263 1.00 11.54 ATOM 2936 CG PHE H 98 17.347 -3.195 1.612 1.00 9.16 ATOM 2937 CD1 PHE H 98 17.375 -4.422 2.262 1.00 6.51 ATOM 2938 CD2 PHE H 98 18.559 -2.584 1.291 1.00 9.14 ATOM 2939 CEI PHEH 98 18.590 -5.041 2.585 1.00 9.69 ATOM 2940 CE2 PHE H 98 19.764 -3.190 1.617 1.00 8.35 ATOM 2941 CZ PHEH 98 19.785 -4.432 2.266 1.00 6.22 ATOM 2942 C PHEH 98 14.061 -2.278 -0.191 1.00 10.16 ATOM 2943 O PHEH 98 13.591 -1.636 0.736 1.00 11.80 ATOM 2944 N ALA H 101 13.475 -2.339 -1.365 1.00 9.29 ATOM 2946 CA ALA H 101 12.250 -1.634 -1.622 1.00 8.04 ATOM 2947 CB ALAH 101 11.991 -1.549 -3.111 1.00 6.69 ATOM 2948 C ALA H 101 11.074 -2.298 -0.962 1.00 11.49 ATOM 2949 O ALA H 101 10.142 -1.595 -0.529 1.00 11.63 ATOM 2950 N TYRH 102 11.101 -3.645 -0.923 1.00 8.89 ATOM 2952 CA TYR H 102 9.998 -4.417 -0.365 1.00 13.48 ATOM 2953 CB TYRH 102 9.566 -5.515 -1.327 1.00 17.64 ATOM 2954 CG TYR H 102 9.270 -5.035 -2.711 1.00 19.49 ATOM 2955 CD1 TYR H 102 8.742 -3.765 -2.921 1.00 19.65 ATOM 2956 CE1 TYRH 102 8.440 -3.311 -4.190 1.00 19.68 ATOM 2957 CD2 TYR H 102 9.498 -5.856 -3.816 1.00 21.83 ATOM 2958 CE2 TYR H 102 9.193 -5.399 -5.093 1.00 24.66 ATOM 2959 CZ TYRH 102 8.658 -4.126 -5.266 1.0021.57 ATOM 2960 OH TYR H 102 8.255 -3.706 -6.526 1.00 29.25 ATOM 2962 C TYRH 102 10.410 -5.062 0.923 1.00 10.63 ATOM 2963 O TYRH 102 11.507 -5.608 1.019 1.00 10.52 ATOM 2964 N TRP H 103 9.522 -4.971 1.884 1.00 12.90 ATOM 2966 CA TRP H 103 9.734 -5.491 3.246 1.00 12.06 ATOM 2967 CB TRP H 103 9.979 -4.325 4.256 1.00 10.97 ATOM 2968 CG TRPH 103 11.293 -3.613 4.125 1.00 7.64 ATOM 2969 CD2 TRP H 103 12.445 -3.715 5.028 1.00 7.34 ATOM 2970 CE2 TRP H 103 13.461 -2.945 4.476 1.00 2.00 ATOM 2971 CE3 TRP H 103 12.692 -4.388 6.241 1.00 2.00 ATOM 2972 CDI TRPH 103 11.676 -2.790 3.109 1.00 2.00 ATOM 2973 NE1 TRP H 103 12.957 -2.399 3.334 1.00 5.49 ATOM 2975 CZ2 TRP H 103 14.718 -2.824 5.073 1.00 6.14 ATOM 2976 CZ3 TRP H 103 13.922 -4.274 6.837 1.00 4.72 ATOM 2977 CH2 TRP H 103 14.930 -3.503 6.264 1.00 4.93 ATOM 2978 C TRP H 103 8.450 -6.196 3.663 1.00 10.58 ATOM 2979 O TRPH 103 7.349 -5.699 3.367 1.00 12.28 ATOM 2980 N GLYH 104 8.555 -7.366 4.288 1.00 9.92 ATOM 2982 CA GLYH 104 7.338 -7.982 4.799 1.00 8.86 ATOM 2983 C GLYH 104 6.892 -7.280 6.088 1.00 11.03 ATOM 2984 O GLY H 104 7.500 -6.276 6.495 1.00 7.62 ATOM 2985 N GLNH 105 5.872 -7.822 6.744 1.00 14.11 ATOM 2987 CA GLN H 105 5.368 -7.248 7.997 1.00 13.52 ATOM 2988 CB GLN H 105 3.900 -7.701 8.254 1.00 16.08 ATOM 2989 CG GLN H 105 3.725 -9.073 8.885 1.00 16.34 ATOM 2990 CD GLN H 105 4.174 -10.239 8.022 1.00 17.73 ATOM 2991 OE1 GLN H 105 4.238 -10.158 6.808 1.0021.14 ATOM 2992 NE2 GLN H 105 4.489 -11.338 8.655 1.0022.59 ATOM 2995 C GLN H 105 6.271 -7.593 9.179 1.00 13.99 ATOM 2996 O GLN H 105 6.235 -6.907 10.203 1.00 12.82 ATOM 2997 N GLYH 106 7.108 -8.638 9.007 1.00 13.67 ATOM 2999 CA GLY H 106 8.032 -9.058 10.049 1.00 11.11 ATOM 3000 C GLY H 106 7.440 -10.150 10.927 1.00 12.32 ATOM 3001 O GLYH 106 6.213 -10.266 11.071 1.00 11.02 ATOM 3002 N THR H 107 8.303 -10.969 11.489 1.00 14.65 ATOM 3004 CA THR H 107 7.861 -12.050 12.387 1.00 12.73 ATOM 3005 CB THRH 107 7.916-13.415 11.638 1.00 10.15 ATOM 3006 OGI THRH 107 7.388-14.451 12.478 1.00 15.55 ATOM 3008 CG2 THR H 107 9.320 -13.770 11.204 1.00 4.69 ATOM 3009 C THRH 107 8.746-12.030 13.619 1.00 10.17 ATOM 3010 O THRH 107 9.951 -11.941 13.485 1.00 10.87 ATOM 3011 N THRH 108 8.174-12.063 14.843 1.00 12.24 ATOM 3013 CA THR H 108 9.036-11.947 16.022 1.00 10.94 WO 99/10379 PCT/GB98/02542 -196 ATOM 3014 CB THRH 108 8.392-11.090 17.206 1.00 12.32 ATOM 3015 OGI THRH 108 9.309-10.902 18.318 1.00 13.78 ATOM 3017 CG2 THR H 108 7.162-11.704 17.736 1.00 15.73 ATOM 3018 C THRH 108 9.597-13.283 16.497 1.00 9.14 ATOM 3019 O THR H 108 8.928 -14.325 16.556 1.00 6.78 ATOM 3020 N VAL H 109 10.857 -13.228 16.755 1.00 8.85 ATOM 3022 CA VAL H 109 11.603 -14.334 17.259 1.00 9.39 ATOM 3023 CB VALH 109 12.782-14.660 16.313 1.00 11.58 ATOM 3024 CGI VALH 109 13.746-15.632 16.965 1.00 5.51 ATOM 3025 CG2 VAL H 109 12.254 -15.239 14.982 1.00 10.69 ATOM 3026 C VALH 109 12.175-13.884 18.594 1.00 12.15 ATOM 3027 OVAL H 109 12.918-12.923 18.638 1.00 12.01 ATOM 3028 N THRH 110 11.785-14.562 19.680 1.00 11.46 ATOM 3030 CA THR H 110 12.309-14.249 21.010 1.00 11.24 ATOM 3031 CB THRH 110 11.175-14.060 22.037 1.00 9.63 ATOM 3032 OGI THRH 110 10.208-13.127 21.544 1.00 10.83 ATOM 3034 CG2 THRH 110 11.740-13.573 23.346 1.00 8.99 ATOM 3035 C THRH 110 13.144-15.405 21.498 1.00 7.60 ATOM 3036 O THRH 110 12.661-16.519 21.509 1.00 12.38 ATOM 3037 N VALH 111 14.372-15.151 21.857 1.00 9.00 ATOM 3039 CA VALH 111 15.227-16.192 22.420 1.00 12.99 ATOM 3040 CB VALH 111 16.640 -16.282 21.736 1.00 10.01 ATOM 3041 CGI VAL H 11l 17.398 -17.484 22.286 1.00 8.99 ATOM 3042 CG2 VAL H 111 16.505 -16.383 20.206 1.00 14.22 ATOM 3043 C VALH 111 15.458-15.895 23.918 1.00 13.42 ATOM 3044 O VALHIII 16.267-15.051 24.277 1.0014.03 ATOM 3045 N SERH 112 14.806-16.618 24.779 1.00 15.10 ATOM 3047 CA SERH 112 14.993 -16.380 26.185 1.00 17.45 ATOM 3048 CB SERH 112 13.871 -15.496 26.699 1.00 17.57 ATOM 3049 OG SERH 112 14.114-15.136 28.034 1.00 18.71 ATOM 3051 C SERH 112 14.966-17.667 26.953 1.00 18.74 ATOM 3052 O SERH 112 14.136-18.525 26.687 1.00 21.32 ATOM 3053 N SERH 113 15.847-17.795 27.926 1.0022.03 ATOM 3055 CA SERH 113 15.794-18.957 28.828 1.00 26.34 ATOM 3056 CB SERH 113 17.205 -19.273 29.321 1.00 28.00 ATOM 3057 OG SERH 113 17.811 -18.109 29.887 1.0035.95 ATOM 3059 C SERH 113 14.818-18.759 30.049 1.00 26.98 ATOM 3060 O SER H 113 14.673 -19.666 30.891 1.00 26.75 ATOM 3061 N ALAH 114 14.144-17.583 30.119 1.0025.34 ATOM 3063 CA ALAH 114 13.242-17.263 31.218 1.0023.14 ATOM 3064 CB ALAH 114 12.860-15.786 31.184 1.0022.38 ATOM 3065 C ALAH 114 11.977-18.113 31.210 1.0024.60 ATOM 3066 O ALAH 114 11.415-18.438 30.137 1.0024.23 ATOM 3067 N LYSH 115 11.514-18.449 32.436 1.0023.35 ATOM 3069 CA LYSH 115 10.315-19.244 32.615 1.0023.70 ATOM 3070 CB LYSH 115 10.461 -20.136 33.834 1.0024.56 ATOM 3071 CG LYSH 115 11.658-21.039 33.758 1.0031.61 ATOM 3072 CD LYS H 115 11.624-22.085 34.863 1.00 37.03 ATOM 3073 CE LYS H 115 12.721 -23.133 34.688 1.00 36.28 ATOM 3074 NZ LYSH 115 12.668-24.162 35.769 1.0037.66 ATOM 3078 C LYS H 115 9.095 -18.361 32.786 1.00 21.83 ATOM 3079 O LYSH 115 9.202-17.207 33.182 1.00 19.35 ATOM 3080 N THRH 116 7.929-18.915 32.513 1.0022.54 ATOM 3082 CA THRH 116 6.719-18.145 32.646 1.0025.02 ATOM 3083 CB THRH 116 5.481 -18.992 32.343 1.00 28.05 ATOM 3084 OGI THR H 116 5.582 -19.477 30.988 1.00 31.99 ATOM 3086 CG2 THR H 116 4.195 -18.183 32.500 1.00 25.98 ATOM 3087 C THRH 116 6.667-17.602 34.036 1.00 23.95 ATOM 3088 O THRH 116 7.072 -18.274 34.977 1.00 23.92 ATOM 3089 N THRH 117 6.225-16.385 34.168 1.0024.46 ATOM 3091 CA THRH 117 6.255 -15.706 35.461 1.00 22.17 ATOM 3092 CB THRH 117 7.605-15.005 35.649 1.00 22.94 ATOM 3093 OGI THRH 117 8.671 -15.961 35.443 1.00 19.91 ATOM 3095 CG2THRH 117 7.730-14.414 37.043 1.00 25.03 ATOM 3096 C THRH 117 5.135-14.686 35.504 1.0022.41 ATOM 3097 O THRH117 5.031-13.806 34.631 1.0022.33 ATOM 3098 N PROH 118 4.236-14.811 36.481 1.0021.47 ATOM 3099 CD PRO H 118 4.285 -15.779 37.622 1.00 24.37 ATOM 3100 CA PROH 118 3.128-13.886 36.620 1.0019.44 ATOM 3101 CB PROH 118 2.249-14.585 37.664 1.0021.47 ATOM 3102 CG PROH 118 3.274-15.198 38.569 1.0023.59 ATOM 3103 C PROHll8 3.744-12.593 37.114 1.0016.22 WO 99/10379 PCT/GB98/02542 -197 ATOM 3104 O PRO H 118 4.804-12.624 37.750 1.00 13.84 ATOM 3105 N PROH 119 3.181-11.442 36.814 1.00 14.35 ATOM 3106 CD PROH 119 1.959 -11.207 36.027 1.00 14.96 ATOM 3107 CA PROH 119 3.775-10.192 37.278 1.00 14.79 ATOM 3108 CB PROH 119 3.119 -9.167 36.378 1.00 13.18 ATOM 3109 CG PROH 119 1.742 -9.716 36.246 1.00 13.05 ATOM 3110 C PROH 119 3.420 -9.954 38.716 1.00 13.65 ATOM 3111 O PROH 119 2.351-10.392 39.166 1.00 14.64 ATOM 3112 N THRH 120 4.281 -9.290 39.445 1.00 13.96 ATOM 3114 CA THRH 120 3.852 -8.825 40.759 1.00 12.82 ATOM 3115 CB THRH 120 4.974 -8.766 41.783 1.00 5.50 ATOM 3116 OGI THRH 120 5.854 -7.766 41.423 1.00 20.74 ATOM 3118 CG2THRH 120 5.743 -10.044 41.845 1.00 8.80 ATOM 3119 C THRH 120 3.343 -7.454 40.486 1.00 8.85 ATOM 3120 O THR H 120 4.065 -6.662 39.870 1.00 10.44 ATOM 3121 N VALH 121 2.070 -7.208 40.783 1.00 11.59 ATOM 3123 CA VALH 121 1.455 -5.896 40.488 1.00 8.52 ATOM 3124 CB VALH 121 0.011 -6.064 40.025 1.00 6.26 ATOM 3125 CG1 VALH 121 -0.610 -4.713 39.693 1.00 3.84 ATOM 3126 CG2VALH 121 -0.004 -6.987 38.822 1.00 9.50 ATOM 3127 C VALH 121 1.522 -4.968 41.701 1.0012.01 ATOM 3128 0 VAL H 121 1.283 -5.388 42.839 1.00 10.41 ATOM 3129 N TYRH 122 1.871 -3.715 41.459 1.00 11.35 ATOM 3131 CA TYRH 122 2.094 -2.768 42.551 1.00 11.02 ATOM 3132 CB TYRH 122 3.597 -2.475 42.697 1.00 7.81 ATOM 3133 CG TYRH 122 4.422 -3.681 43.099 1.00 15.44 ATOM 3134 CDI TYR H 122 4.080 -4.436 44.244 1.00 16.70 ATOM 3135 CE1 TYRH 122 4.846 -5.523 44.662 1.00 12.55 ATOM 3136 CD2TYRH 122 5.553 -4.057 42.382 1.00 7.91 ATOM 3137 CE2TYRH 122 6.328 -5.128 42.784 1.00 8.28 ATOM 3138 CZ TYRH 122 5.977 -5.861 43.932 1.00 11.52 ATOM 3139 OH TYRH 122 6.815 -6.850 44.397 1.00 11.02 ATOM 3141 C TYRH 122 1.359 -1.504 42.255 1.00 12.61 ATOM 3142 O TYRH 122 1.438 -0.973 41.184 1.00 11.44 ATOM 3143 N PRO H 123 0.606 -1.001 43.195 1.00 18.80 ATOM 3144 CD PRO H 123 0.485 -1.489 44.591 1.00 19.13 ATOM 3145 CA PRO H 123 -0.164 0.223 43.008 1.00 18.57 ATOM 3146 CB PROH 123 -1.109 0.182 44.199 1.00 15.86 ATOM 3147 CG PROH 123 -0.191 -0.319 45.247 1.00 19.34 ATOM 3148 C PRO H 123 0.769 1.403 43.074 1.00 18.37 ATOM 3149 O PROH 123 1.773 1.373 43.802 1.0024.31 ATOM 3150 N LEU H 124 0.477 2.416 42.305 1.00 17.89 ATOM 3152 CA LEUH 124 1.270 3.628 42.346 1.00 18.57 ATOM 3153 CB LEUH 124 1.954 3.898 41.015 1.00 17.71 ATOM 3154 CG LEUH 124 2.962 2.838 40.535 1.0020.67 ATOM 3155 CDI LEU H 124 3.662 3.341 39.297 1.00 18.20 ATOM 3156 CD2LEUH 124 3.950 2.459 41.651 1.00 18.24 ATOM 3157 C LEUH 124 0.396 4.805 42.758 1.00 18.06 ATOM 3158 O LEUH 124 -0.483 5.272 41.994 1.00 14.26 ATOM 3159 N ALAH 125 0.589 5.214 44.013 1.00 18.65 ATOM 3161 CA ALAH 125 -0.168 6.314 44.583 1.00 16.82 ATOM 3162 CB ALA H 125 -0.580 6.007 46.029 1.00 13.74 ATOM 3163 C ALA H 125 0.682 7.548 44.523 1.00 15.68 ATOM 3164 O ALAH 125 1.896 7.462 44.551 1.00 16.41 ATOM 3165 N PRO H 126 0.059 8.704 44.406 1.00 16.40 ATOM 3166 CD PRO H 126 -1.415 8.893 44.331 1.00 13.85 ATOM 3167 CA PRO H 126 0.771 9.978 44.333 1.00 16.02 ATOM 3168 CB PROH 126 -0.372 11.000 44.314 1.00 15.53 ATOM 3169 CG PRO H 126 -1.481 10.224 43.672 1.00 14.07 ATOM 3170 C PRO H 126 1.740 10.188 45.498 1.00 18.31 ATOM 3171 O PROH 126 1.461 9.848 46.671 1.00 16.34 ATOM 3172 N GLY H 127 2.878 10.736 45.166 1.00 22.48 ATOM 3174 CA GLYH 127 3.860 11.012 46.166 1.0030.63 ATOM 3175 C GLY H 127 3.583 12.326 46.845 1.00 33.75 ATOM 3176 OTI GLYH 127 4.359 13.283 46.589 1.00 39.27 ATOM 3177 OT2 GLY H 127 2.581 12.409 47.625 1.00 35.28 ATOM 3178 CB ALA H 134 -7.921 19.962 39.302 1.00 21.74 ATOM 3179 C ALAH 134 -8.377 17.510 39.469 1.00 25.40 ATOM 3180 O ALAH 134 -9.457 16.953 39.269 1.0026.02 ATOM 3183 N ALAH 134 -7.261 18.732 41.332 1.0024.67 ATOM 3185 CA ALA H 134 -8.291 18.835 40.244 1.00 23.36 ATOM 3186 N METH 135 -7.229 17.059 38.997 1.0024.22 WO 99/10379 PCT/GB98/02542 -198 ATOM 3188 CA MET H 135 -7.095 15.775 38.333 1.0026.09 ATOM 3189 CB METH 135 -6.684 15.971 36.852 1.0030.45 ATOM 3190 CG MET H 135 -7.835 16.193 35.855 1.0034.99 ATOM 3191 SD METH 135 -8.958 14.753 35.759 1.0046.83 ATOM 3192 CE METH 135 -8.784 14.216 34.059 1.0042.78 ATOM 3193 C METH 135 -5.978 15.070 39.074 1.0025.74 ATOM 3194 O METH 135 -5.028 15.734 39.523 1.0025.90 ATOM 3195 N VALH 136 -6.074 13.773 39.258 1.0022.09 ATOM 3197 CA VAL H 136 -5.001 13.072 39.935 1.00 18.97 ATOM 3198 CB VALH 136 -5.429 12.618 41.367 1.00 16.24 ATOM 3199 CGI VALH 136 -6.694 11.797 41.355 1.00 15.37 ATOM 3200 CG2 VAL H 136 -4.297 11.870 42.020 1.00 16.51 ATOM 3201 C VALH 136 -4.555 11.889 39.100 1.00 17.30 ATOM 3202 0 VAL H 136 -5.397 11.220 38.485 1.00 17.97 ATOM 3203 N THRH 137 -3.245 11.643 39.035 1.00 17.82 ATOM 3205 CA THRH 137 -2.783 10.483 38.276 1.00 18.38 ATOM 3206 CB THRH 137 -1.731 10.855 37.238 1.00 15.72 ATOM 3207 OGI THRH 137 -2.313 11.857 36.384 1.00 16.58 ATOM 3209 CG2THRH 137 -1.374 9.644 36.382 1.00 13.21 ATOM 3210 C THRH 137 -2.287 9.336 39.164 1.00 16.41 ATOM 3211 O THRH 137 -1.405 9.514 40.023 1.00 14.38 ATOM 3212 N LEUH 138 -2.924 8.182 38.940 1.00 13.46 ATOM 3214 CA LEUH 138 -2.617 6.950 39.647 1.00 11.93 ATOM 3215 CB LEU H 138 -3.897 6.401 40.222 1.00 9.54 ATOM 3216 CG LEU H 138 -4.690 7.402 41.030 1.00 9.64 ATOM 3217 CDI LEUH 138 -5.943 6.750 41.531 1.00 11.85 ATOM 3218 CD2 LEU H 138 -3.839 7.920 42.174 1.00 6.56 ATOM 3219 C LEUH 138 -2.046 5.964 38.649 1.00 12.78 ATOM 3220 O LEU H 138 -2.281 6.106 37.457 1.00 10.57 ATOM 3221 N GLYH 139 -1.316 4.988 39.106 1.00 11.80 ATOM 3223 CA GLYH 139 -0.770 4.041 38.174 1.00 11.77 ATOM 3224 C GLYH 139 -0.578 2.682 38.763 1.00 14.58 ATOM 3225 O GLY H 139 -0.863 2.452 39.936 1.00 14.52 ATOM 3226 N CYS H 140 -0.090 1.781 37.952 1.00 13.05 ATOM 3228 CA CYS H 140 0.182 0.447 38.375 1.00 12.15 ATOM 3229 CB CYS H 140 -0.942 -0.487 37.970 1.00 15.82 ATOM 3230 SG CYS H 140 -1.991 -0.935 39.377 1.00 30.05 ATOM 3231 C CYS H 140 1.438 -0.028 37.762 1.00 9.66 ATOM 3232 O CYS H 140 1.589 0.121 36.548 1.00 8.35 ATOM 3233 N LEU H 141 2.337 -0.555 38.594 1.00 6.85 ATOM 3235 CA LEUH 141 3.554 -1.210 38.112 1.00 10.45 ATOM 3236 CB LEUH 141 4.728 -1.024 39.075 1.00 3.00 ATOM 3237 CG LEUH 141 6.061 -1.672 38.701 1.00 7.34 ATOM 3238 CD1 LEU H 141 6.581 -1.153 37.363 1.00 7.63 ATOM 3239 CD2 LEU H 141 7.091 -1.374 39.751 1.00 2.28 ATOM 3240 C LEU H 141 3.299 -2.708 37.948 1.00 9.22 ATOM 3241 O LEU H 141 2.819 -3.363 38.869 1.00 8.85 ATOM 3242 N VALH 142 3.550 -3.220 36.751 1.0010.01 ATOM 3244 CA VAL H 142 3.449 -4.641 36.484 1.00 7.47 ATOM 3245 CB VAL H 142 2.629 -4.891 35.208 1.00 10.12 ATOM 3246 CGI VAL H 142 2.421 -6.409 34.967 1.00 8.96 ATOM 3247 CG2VALH 142 1.282 -4.167 35.330 1.00 6.58 ATOM 3248 C VALH 142 4.880 -5.167 36.351 1.00 11.16 ATOM 3249 0 VAL H 142 5.513 -5.101 35.263 1.00 6.29 ATOM 3250 N LYS H 143 5.393 -5.690 37.460 1.00 9.75 ATOM 3252 CA LYS H 143 6.804 -6.016 37.537 1.00 12.16 ATOM 3253 CB LYS H 143 7.348 -5.453 38.844 1.00 9.61 ATOM 3254 CG LYS H 143 8.868 -5.354 38.937 1.00 9.64 ATOM 3255 CD LYS H 143 9.275 -4.918 40.340 1.00 11.17 ATOM 3256 CE LYS H 143 10.793 -4.938 40.495 1.00 15.36 ATOM 3257 NZ LYS H 143 11.200 -5.003 41.925 1.00 13.08 ATOM 3261 C LYS H 143 7.158 -7.514 37.403 1.00 14.70 ATOM 3262 O LYS H 143 6.437 -8.400 37.861 1.00 17.80 ATOM 3263 N GLY H 144 8.250 -7.745 36.687 1.00 16.56 ATOM 3265 CA GLY H 144 8.881 -9.067 36.594 1.00 18.62 ATOM 3266 C GLY H 144 8.089-10.220 36.006 1.00 16.58 ATOM 3267 O GLYH 144 8.190-11.328 36.517 1.0020.26 ATOM 3268 N TYR H 145 7.362-10.004 34.922 1.00 15.03 ATOM 3270 CA TYRH 145 6.614-11.103 34.286 1.00 12.99 ATOM 3271 CB TYR H 145 5.208 -10.660 33.827 1.00 10.99 ATOM 3272 CG TYRH 145 5.135 -9.584 32.771 1.00 13.14 ATOM 3273 CDI TYRH 145 5.416 -8.267 33.096 1.00 15.73 WO 99/10379 PCT/GB98/02542 -199 ATOM 3274 CEl TYR H 145 5.282 -7.258 32.165 1.00 12.07 ATOM 3275 CD2 TYR H 145 4.716 -9.850 31.460 1.00 15.71 ATOM 3276 CE2 TYR H 145 4.582 -8.826 30.509 1.00 9.54 ATOM 3277 CZ TYRH 145 4.873 -7.534 30.876 1.00 10.77 ATOM 3278 OH TYRH 145 4.831 -6.497 29.946 1.00 9.76 ATOM 3280 C TYRH 145 7.377-11.654 33.088 1.00 13.49 ATOM 3281 O TYRH 145 8.359-11.074 32.659 1.00 12.72 ATOM 3282 N PHE H 146 6.944 -12.803 32.602 1.00 16.82 ATOM 3284 CA PHE H 146 7.473 -13.382 31.370 1.00 18.55 ATOM 3285 CB PHEH 146 8.904-13.878 31.511 1.00 18.86 ATOM 3286 CG PHE H 146 9.412 -14.458 30.205 1.00 23.23 ATOM 3287 CDI PHE H 146 10.213 -13.700 29.365 1.00 25.00 ATOM 3288 CD2 PHE H 146 8.973 -15.715 29.749 1.00 24.90 ATOM 3289 CEI PHE H 146 10.555 -14.162 28.084 1.00 26.32 ATOM 3290 CE2 PHE H 146 9.304-16.185 28.488 1.0026.32 ATOM 3291 CZ PHEH 146 10.092-15.407 27.646 1.0025.16 ATOM 3292 C PHEH 146 6.649-14.556 31.022 1.00 19.54 ATOM 3293 O PHEH 146 6.362-15.325 31.931 1.00 18.10 ATOM 3294 N PRO H 147 6.212 -14.746 29.719 1.0021.47 ATOM 3295 CD PRO H 147 4.947 -15.427 29.403 1.00 21.60 ATOM 3296 CA PRO H 147 6.425 -13.870 28.551 1.00 21.86 ATOM 3297 CB PRO H 147 6.189 -14.884 27.403 1.0021.39 ATOM 3298 CG PRO H 147 5.240-15.912 28.012 1.00 19.80 ATOM 3299 C PRO H 147 5.429 -12.695 28.485 1.00 18.87 ATOM 3300 O PRO H 147 4.635 -12.517 29.377 1.00 15.77 ATOM 3301 N GLU H 148 5.418 -11.983 27.333 1.00 19.05 ATOM 3303 CA GLU H 148 4.398 -10.982 27.056 1.00 19.21 ATOM 3304 CB GLU H 148 4.970 -9.897 26.157 1.00 17.80 ATOM 3305 CG GLU H 148 6.120 -9.149 26.752 1.00 15.35 ATOM 3306 CD GLU H 148 6.491 -7.960 25.920 1.00 19.90 ATOM 3307 OE1 GLU H 148 7.608 -7.957 25.354 1.00 23.72 ATOM 3308 OE2 GLU H 148 5.670 -7.015 25.826 1.00 17.13 ATOM 3309 C GLU H 148 3.287 -11.666 26.280 1.00 19.80 ATOM 3310 O GLUH 148 3.495-12.766 25.824 1.0021.47 ATOM 3311 N PROH 149 2.074-11.085 26.123 1.00 19.34 ATOM 3312 CD PROH 149 0.842-11.841 25.966 1.00 15.47 ATOM 3313 CA PRO H 149 1.637 -9.812 26.659 1.00 18.47 ATOM 3314 CB PROH 149 0.524 -9.460 25.678 1.00 18.21 ATOM 3315 CG PROH 149 0.018-10.824 25.214 1.00 17.16 ATOM 3316 C PRO H 149 1.103 -9.887 28.117 1.00 18.85 ATOM 3317 O PROH 149 1.155-10.899 28.823 1.00 16.35 ATOM 3318 N VALH 150 0.418 -8.814 28.427 1.00 19.66 ATOM 3320 CA VALH 150 -0.234 -8.572 29.679 1.00 16.78 ATOM 3321 CB VAL H 150 0.816 -7.977 30.670 1.00 16.55 ATOM 3322 CGI VAL H 150 0.488 -6.566 31.077 1.00 17.59 ATOM 3323 CG2 VAL H 150 0.998 -8.878 31.854 1.00 13.17 ATOM 3324 C VAL H 150 -1.324 -7.580 29.302 1.00 16.49 ATOM 3325 0 VALH 150 -1.165 -6.832 28.343 1.00 18.33 ATOM 3326 N THRH 151 -2.459 -7.653 29.919 1.00 14.32 ATOM 3328 CA THRH 151 -3.527 -6.716 29.637 1.00 14.69 ATOM 3329 CB THRH 151 -4.778 -7.448 29.097 1.00 17.81 ATOM 3330 OGI THRH 151 -5.351 -8.263 30.141 1.00 22.14 ATOM 3332 CG2 THR H 151 -4.396 -8.364 27.922 1.00 20.30 ATOM 3333 C THRH 151 -3.899 -5.978 30.920 1.00 13.72 ATOM 3334 O THRH 151 -4.195 -6.613 31.921 1.00 13.94 ATOM 3335 N VAL H 152 -3.912 -4.657 30.864 1.00 12.98 ATOM 3337 CA VALH 152 -4.175 -3.843 32.041 1.00 12.73 ATOM 3338 CB VAL H 152 -2.967 -2.947 32.373 1.00 11.49 ATOM 3339 CG1 VALH 152 -3.279 -2.108 33.610 1.00 11.37 ATOM 3340 CG2 VAL H 152 -1.719 -3.792 32.608 1.00 9.03 ATOM 3341 C VALH 152 -5.401 -2.965 31.864 1.00 15.95 ATOM 3342 0 VALH 152 -5.481 -2.170 30.914 1.00 19.74 ATOM 3343 N THRH 153 -6.370 -3.124 32.770 1.00 19.44 ATOM 3345 CA THRH 153 -7.587 -2.324 32.746 1.00 19.80 ATOM 3346 CB THRH 153 -8.820 -3.223 32.528 1.00 21.72 ATOM 3347 OGI THR H 153 -8.652 -4.412 33.286 1.00 26.52 ATOM 3349 CG2THRH 153 -8.974 -3.597 31.063 1.00 21.56 ATOM 3350 C THRH 153 -7.761 -1.521 34.064 1.00 17.98 ATOM 3351 O THR H 153 -7.047 -1.744 35.043 1.00 17.86 ATOM 3352 N TRP H 154 -8.681 -0.562 34.054 1.00 18.02 ATOM 3354 CA TRPH 154 -8.954 0.231 35.232 1.00 16.37 ATOM 3355 CB TRPH 154 -8.438 1.620 35.052 1.00 15.29 WO 99/10379 PCT/GB98/02542 -200 ATOM 3356 CG TRP H 154 -6.960 1.649 34.987 1.00 14.01 ATOM 3357 CD2 TRP H 154 -6.070 1.827 36.097 1.00 14.22 ATOM 3358 CE2 TRP H 154 -4.766 1.906 35.577 1.00 12.55 ATOM 3359 CE3 TRP H 154 -6.261 1.950 37.493 1.00 13.71 ATOM 3360 CD1 TRP H 154 -6.189 1.608 33.866 1.00 13.72 ATOM 3361 NEI TRP H 154 -4.881 1.763 34.225 1.00 14.65 ATOM 3363 CZ2TRPH 154 -3.652 2.112 36.377 1.00 11.60 ATOM 3364 CZ3 TRPH 154 -5.153 2.164 38.288 1.00 13.74 ATOM 3365 CH2 TRP H 154 -3.865 2.247 37.720 1.00 15.50 ATOM 3366 C TRPH 154 -10.423 0.226 35.482 1.00 16.57 ATOM 3367 O TRP H 154 -11.208 0.444 34.565 1.00 19.07 ATOM 3368 N ASN H 155 -10.781 -0.062 36.722 1.00 18.63 ATOM 3370 CA ASN H 155 -12.177 -0.278 37.117 1.00 19.34 ATOM 3371 CB ASN H 155 -12.895 1.047 37.330 1.00 19.07 ATOM 3372 CG ASN H 155 -12.499 1.668 38.658 1.00 19.37 ATOM 3373 ODI ASN H 155 -11.818 1.048 39.479 1.00 17.72 ATOM 3374 ND2 ASN H 155 -12.904 2.898 38.869 1.0021.85 ATOM 3377 C ASNH 155 -12.902 -1.167 36.114 1.0020.59 ATOM 3378 O ASNH 155 -13.989 -0.851 35.645 1.00 19.83 ATOM 3379 N SERH 156 -12.232 -2.290 35.767 1.0022.94 ATOM 3381 CA SERH 156 -12.740 -3.255 34.801 1.0023.80 ATOM 3382 CB SERH 156 -14.028 -3.890 35.333 1.0024.08 ATOM 3383 OG SERH 156 -13.778 -4.574 36.550 1.0023.19 ATOM 3385 C SERH 156 -12.968 -2.650 33.393 1.0026.88 ATOM 3386 O SERH 156 -13.730 -3.185 32.575 1.0029.20 ATOM 3387 N GLYH 157 -12.293 -1.561 33.090 1.00 26.24 ATOM 3389 CA GLY H 157 -12.488 -0.966 31.798 1.0028.52 ATOM 3390 C GLYH 157 -13.553 0.129 31.789 1.0028.13 ATOM 3391 O GLYH 157 -13.793 0.740 30.741 1.0028.70 ATOM 3392 N SERH 158 -14.194 0.371 32.945 1.0027.82 ATOM 3394 CA SERH 158 -15.164 1.445 33.049 1.0027.17 ATOM 3395 CB SERH 158 -16.045 1.301 34.334 1.00 28.51 ATOM 3396 OG SERH 158 -15.342 1.560 35.537 1.0025.88 ATOM 3398 C SERH 158 -14.420 2.768 33.007 1.00 27.55 ATOM 3399 O SERH 158 -14.947 3.772 32.555 1.0028.23 ATOM 3400 N LEUH 159 -13.177 2.753 33.491 1.0029.42 ATOM 3402 CA LEU H 159 -12.295 3.898 33.352 1.0030.68 ATOM 3403 CB LEUH 159 -11.288 3.966 34.495 1.00 31.18 ATOM 3404 CG LEUH 159 -11.756 4.650 35.788 1.0029.87 ATOM 3405 CD1 LEUH 159 -10.635 4.657 36.819 1.00 34.45 ATOM 3406 CD2 LEU H 159 -12.186 6.067 35.491 1.0029.03 ATOM 3407 C LEUH 159 -11.571 3.717 32.042 1.0031.97 ATOM 3408 O LEU H 159 -10.554 3.036 31.980 1.00 31.21 ATOM 3409 N ALA H 160 -12.168 4.261 30.990 1.0034.61 ATOM 3411 CA ALA H 160 -11.634 4.120 29.629 1.00 35.80 ATOM 3412 CB ALA H 160 -12.804 3.926 28.668 1.00 34.51 ATOM 3413 C ALA H 160 -10.776 5.337 29.226 1.0035.27 ATOM 3414 O ALA H 160 -9.611 5.209 28.796 1.00 34.38 ATOM 3415 N SERH 161 -11.347 6.517 29.381 1.0033.77 ATOM 3417 CA SERH 161 -10.624 7.747 29.083 1.00 33.98 ATOM 3418 CB SERH I61 -11.613 8.911 29.028 1.0033.96 ATOM 3419 OG SERH 161 -12.943 8.420 28.847 1.00 38.30 ATOM 3421 C SERH 161 -9.560 8.020 30.155 1.00 30.88 ATOM 3422 O SERH 161 -9.693 7.603 31.314 1.00 32.73 ATOM 3423 N GLYH 162 -8.502 8.702 29.765 1.0028.58 ATOM 3425 CA GLY H 162 -7.480 9.082 30.742 1.00 23.36 ATOM 3426 C GLYH 162 -6.467 8.005 31.081 1.00 19.44 ATOM 3427 O GLYH 162 -5.669 8.193 32.016 1.00 17.19 ATOM 3428 N VAL H 163 -6.462 6.913 30.296 1.00 16.90 ATOM 3430 CA VAL H 163 -5.546 5.808 30.529 1.00 14.28 ATOM 3431 CB VAL H 163 -6.243 4.469 30.285 1.00 11.19 ATOM 3432 CGI VAL H 163 -5.256 3.321 30.477 1.00 9.55 ATOM 3433 CG2 VAL H 163 -7.402 4.343 31.259 1.00 8.14 ATOM 3434 C VAL H 163 -4.318 5.896 29.644 1.00 16.70 ATOM 3435 0 VAL H 163 -4.409 6.341 28.504 1.00 20.46 ATOM 3436 N HIS H 164 -3.190 5.493 30.176 1.00 12.44 ATOM 3438 CA HIS H 164 -1.964 5.449 29.434 1.00 12.24 ATOM 3439 CB HIS H 164 -1.048 6.574 29.835 1.00 12.04 ATOM 3440 CG HIS H 164 -1.363 7.839 29.187 1.00 17.45 ATOM 3441 CD2 HIS H 164 -1.795 9.016 29.683 1.00 16.45 ATOM 3442 NDI HIS H 164 -1.111 8.058 27.848 1.00 19.78 ATOM 3444 CE1 HIS H 164 -1.345 9.283 27.520 1.00 18.88 WO 99/10379 PCT/GB98/02542 -201 ATOM 3445 NE2 HIS H 164 -1.749 9.883 28.620 1.00 19.92 ATOM 3447 C HIS H 164 -1.249 4.202 29.775 1.00 12.66 ATOM 3448 O HIS H 164 -0.920 4.010 30.928 1.00 12.50 ATOM 3449 N THRH 165 -1.023 3.327 28.830 1.00 12.38 ATOM 3451 CA THRH 165 -0.198 2.176 29.140 1.00 10.10 ATOM 3452 CB THRH 165 -0.932 0.859 28.952 1.00 9.55 ATOM 3453 OGI THRH 165 -2.129 0.919 29.729 1.00 11.21 ATOM 3455 CG2 THR H 165 -0.086 -0.307 29.427 1.00 8.04 ATOM 3456 C THRH 165 1.047 2.227 28.313 1.00 11.67 ATOM 3457 O THRH 165 0.973 2.441 27.118 1.00 10.32 ATOM 3458 N PHEH 166 2.188 2.057 28.992 1.00 11.57 ATOM 3460 CA PHE H 166 3.508 2.196 28.398 1.00 12.01 ATOM 3461 CB PHE H 166 4.399 2.957 29.415 1.00 9.65 ATOM 3462 CG PHE H 166 3.773 4.286 29.831 1.00 8.07 ATOM 3463 CD1 PHE H 166 2.850 4.349 30.874 1.00 4.17 ATOM 3464 CD2 PHE H 166 4.009 5.459 29.082 1.00 10.68 ATOM 3465 CE1 PHEH 166 2.156 5.542 31.164 1.00 8.24 ATOM 3466 CE2 PHE H 166 3.318 6.659 29.363 1.00 11.02 ATOM 3467 CZ PHE H 166 2.385 6.699 30.401 1.00 5.44 ATOM 3468 C PHEH 166 4.110 0.820 28.001 1.00 15.40 ATOM 3469 O PHE H 166 3.559 -0.237 28.381 1.00 16.48 ATOM 3470 N PRO H 167 5.212 0.823 27.173 1.00 14.51 ATOM 3471 CD PRO H 167 5.834 2.019 26.553 1.00 14.57 ATOM 3472 CA PRO H 167 5.902 -0.394 26.687 1.00 13.56 ATOM 3473 CB PRO H 167 6.851 0.140 25.578 1.00 15.95 ATOM 3474 CG PROH 167 6.300 1.475 25.231 1.00 15.19 ATOM 3475 C PROH 167 6.713 -1.111 27.754 1.00 13.70 ATOM 3476 O PRO H 167 7.304 -0.467 28.629 1.00 8.91 ATOM 3477 N ALA H 168 6.768 -2.446 27.620 1.00 14.48 ATOM 3479 CA ALAH 168 7.525 -3.290 28.526 1.00 13.11 ATOM 3480 CB ALA H 168 7.259 -4.768 28.238 1.00 12.04 ATOM 3481 C ALA H 168 8.998 -3.015 28.403 1.00 15.12 ATOM 3482 O ALA H 168 9.510 -2.693 27.324 1.00 14.20 ATOM 3483 N VAL H 169 9.674 -3.048 29.527 1.00 14.23 ATOM 3485 CA VAL H 169 11.092 -2.935 29.530 1.00 11.53 ATOM 3486 CB VAL H 169 11.646 -1.809 30.491 1.00 10.77 ATOM 3487 CG1 VAL H 169 11.409 -0.432 29.901 1.00 5.38 ATOM 3488 CG2 VAL H 169 10.977 -1.881 31.846 1.00 8.65 ATOM 3489 C VAL H 169 11.580 -4.290 29.967 1.00 14.43 ATOM 3490 0 VAL H 169 10.866 -4.984 30.681 1.00 13.16 ATOM 3491 N LEU H 170 12.733 -4.698 29.458 1.00 16.49 ATOM 3493 CA LEU H 170 13.360 -5.934 29.890 1.00 20.55 ATOM 3494 CB LEU H 170 13.982 -6.690 28.693 1.00 17.41 ATOM 3495 CG LEU H 170 14.389 -8.169 28.931 1.00 16.89 ATOM 3496 CD1 LEUH 170 13.177 -8.978 29.315 1.00 11.20 ATOM 3497 CD2 LEU H 170 15.030 -8.777 27.681 1.00 13.43 ATOM 3498 C LEUH 170 14.432 -5.611 30.913 1.00 21.20 ATOM 3499 O LEU H 170 15.435 -4.967 30.608 1.00 23.98 ATOM 3500 N GLNH 171 14.191 -6.002 32.149 1.0025.48 ATOM 3502 CA GLNH 171 15.171 -5.804 33.183 1.0027.97 ATOM 3503 CB GLN H 171 14.922 -4.486 33.992 1.0033.14 ATOM 3504 CG GLNH 171 13.467 -4.032 34.231 1.0035.78 ATOM 3505 CD GLNH 171 13.348 -2.498 34.464 1.0041.72 ATOM 3506 OE1 GLNH 171 14.208 -1.718 34.023 1.0043.19 ATOM 3507 NE2 GLN H 171 12.286 -2.049 35.139 1.00 39.50 ATOM 3510 C GLN H 171 15.236 -7.032 34.075 1.00 30.85 ATOM 3511 O GLNH 171 14.308 -7.309 34.845 1.0030.30 ATOM 3512 N ALAH 172 16.311 -7.811 33.886 1.0030.98 ATOM 3514 CA ALA H 172 16.565 -9.035 34.683 1.00 32.89 ATOM 3515 CB ALA H 172 16.048 -8.870 36.135 1.00 34.56 ATOM 3516 C ALA H 172 15.964 -10.296 34.037 1.00 32.42 ATOM 3517 O ALAH 172 15.562-11.243 34.745 1.0033.51 ATOM 3518 N ALAH 173 15.975-10.316 32.681 1.0028.84 ATOM 3520 CA ALAH 173 15.362-11.388 31.898 1.0024.12 ATOM 3521 CB ALA H 173 15.866-12.773 32.316 1.0024.73 ATOM 3522 C ALAH 173 13.846-11.340 31.998 1.0022.90 ATOM 3523 O ALA H 173 13.168-12.169 31.422 1.0024.63 ATOM 3524 N LEU H 174 13.301 -10.353 32.701 1.00 19.03 ATOM 3526 CA LEU H 174 11.859-10.286 32.881 1.00 16.09 ATOM 3527 CB LEU H 174 11.495 -10.523 34.374 1.00 13.53 ATOM 3528 CG LEU H 174 11.811 -11.911 35.012 1.00 13.70 ATOM 3529 CDI LEU H 174 11.331 -11.910 36.473 1.00 13.19 WO 99/10379 PCT/GB98/02542 -202 ATOM 3530 CD2 LEU H 174 11.119-13.044 34.233 1.00 7.07 ATOM 3531 C LEU H 174 11.362 -8.938 32.423 1.00 11.64 ATOM 3532 O LEU H 174 12.101 -7.992 32.465 1.00 13.03 ATOM 3533 N TYRH 175 10.141 -8.885 31.993 1.00 11.45 ATOM 3535 CA TYRH 175 9.528 -7.647 31.500 1.00 13.69 ATOM 3536 CB TYRH 175 8.486 -7.939 30.415 1.00 13.82 ATOM 3537 CG TYRH 175 9.037 -8.570 29.180 1.00 14.75 ATOM 3538 CD1 TYRH 175 9.958 -7.891 28.408 1.00 17.41 ATOM 3539 CE1 TYRH 175 10.501 -8.438 27.254 1.00 18.34 ATOM 3540 CD2 TYR H 175 8.648 -9.834 28.779 1.00 18.01 ATOM 3541 CE2 TYR H 175 9.177 -10.401 27.619 1.0020.37 ATOM 3542 CZ TYRH 175 10.111 -9.689 26.860 1.00 19.65 ATOM 3543 OH TYRH 175 10.636 -10.221 25.713 1.00 21.14 ATOM 3545 C TYRH 175 8.792 -6.860 32.607 1.00 16.88 ATOM 3546 O TYRH 175 8.132 -7.440 33.503 1.00 15.69 ATOM 3547 N THRH 176 8.837 -5.537 32.473 1.00 14.27 ATOM 3549 CA THRH 176 8.140 -4.643 33.386 1.00 13.28 ATOM 3550 CB THRH 176 9.132 -3.928 34.356 1.00 11.07 ATOM 3551 OG1 THRH 176 9.739 -4.862 35.272 1.00 9.99 ATOM 3553 CG2 THR H 176 8.402 -2.859 35.144 1.00 7.94 ATOM 3554 C THRH 176 7.416 -3.575 32.590 1.00 11.40 ATOM 3555 O THRH 176 8.006 -2.982 31.696 1.00 10.96 ATOM 3556 N LEUH 177 6.149 -3.354 32.842 1.00 9.44 ATOM 3558 CA LEUH 177 5.521 -2.199 32.219 1.00 11.96 ATOM 3559 CB LEU H 177 4.761 -2.522 30.908 1.00 12.44 ATOM 3560 CG LEU H 177 3.533 -3.426 30.906 1.00 13.51 ATOM 3561 CD1 LEU H 177 2.348 -2.763 31.614 1.00 16.92 ATOM 3562 CD2 LEU H 177 3.147 -3.709 29.455 1.00 19.97 ATOM 3563 C LEUH 177 4.690 -1.441 33.227 1.00 11.72 ATOM 3564 O LEU H 177 4.676 -1.805 34.410 1.00 12.02 ATOM 3565 N SERH 178 4.086 -0.366 32.806 1.00 9.83 ATOM 3567 CA SERH 178 3.269 0.430 33.698 1.00 12.66 ATOM 3568 CB SERH 178 4.026 1.657 34.240 1.00 16.23 ATOM 3569 OG SERH 178 5.018 1.303 35.164 1.0021.15 ATOM 3571 C SERH 178 2.070 0.944 32.978 1.00 11.78 ATOM 3572 O SERH 178 2.032 0.978 31.750 1.00 12.05 ATOM 3573 N SERH 179 1.112 1.350 33.755 1.00 10.09 ATOM 3575 CA SERH 179 -0.072 1.975 33.256 1.00 9.78 ATOM 3576 CB SERH 179 -1.203 0.965 33.162 1.00 7.12 ATOM 3577 OG SERH 179 -2.348 1.479 32.502 1.00 13.99 ATOM 3579 C SERH 179 -0.424 3.060 34.240 1.00 11.73 ATOM 3580 O SERH 179 0.023 3.028 35.402 1.00 10.99 ATOM 3581 N SERH 180 -1.190 4.008 33.791 1.00 12.62 ATOM 3583 CA SERH 180 -1.623 5.095 34.634 1.00 11.78 ATOM 3584 CB SERH 180 -0.620 6.257 34.502 1.00 15.26 ATOM 3585 OG SERH 180 -0.740 6.935 33.258 1.00 15.98 ATOM 3587 C SERH 180 -3.036 5.542 34.226 1.00 11.26 ATOM 3588 O SERH 180 -3.404 5.337 33.078 1.00 12.64 ATOM 3589 N VALH 181 -3.845 6.053 35.189 1.00 12.70 ATOM 3591 CA VAL H 181 -5.145 6.681 34.903 1.00 12.65 ATOM 3592 CB VALH 181 -6.398 6.141 35.610 1.00 14.52 ATOM 3593 CGI VALH 181 -7.464 5.805 34.614 1.00 8.51 ATOM 3594 CG2 VAL H 181 -6.095 5.069 36.613 1.00 15.67 ATOM 3595 C VALH 181 -5.132 8.053 35.502 1.00 13.40 ATOM 3596 0 VAL H 181 -4.566 8.240 36.557 1.00 10.66 ATOM 3597 N THRH 182 -5.823 8.979 34.847 1.00 15.42 ATOM 3599 CA THRH 182 -6.030 10.289 35.405 1.00 12.05 ATOM 3600 CB THRH 182 -5.479 11.385 34.498 1.00 12.00 ATOM 3601 OGI THRH 182 -4.067 11.178 34.367 1.00 12.34 ATOM 3603 CG2 THR H 182 -5.725 12.775 35.097 1.00 10.88 ATOM 3604 C THRH 182 -7.500 10.451 35.616 1.00 15.30 ATOM 3605 O THRH 182 -8.317 10.224 34.692 1.00 15.69 ATOM 3606 N VAL H 183 -7.839 10.749 36.868 1.00 15.89 ATOM 3608 CA VAL H 183 -9.228 10.916 37.295 1.00 15.70 ATOM 3609 CB VALH 183 -9.692 9.764 38.256 1.00 13.11 ATOM 3610 CG1 VAL H 183 -9.836 8.464 37.491 1.00 16.73 ATOM 3611 CG2 VAL H 183 -8.703 9.586 39.372 1.00 7.49 ATOM 3612 C VAL H 183 -9.376 12.225 38.045 1.00 14.30 ATOM 3613 0 VALH 183 -8.403 12.765 38.527 1.00 15.26 ATOM 3614 N PRO H 184 -10.595 12.766 38.162 1.00 15.74 ATOM 3615 CD PRO H 184 -11.858 12.234 37.661 1.00 15.39 ATOM 3616 CA PRO H 184 -10.802 14.004 38.892 1.00 16.30 WO 99/10379 PCT/GB98/02542 -203 ATOM 3617 CB PRO H 184 -12.304 14.274 38.739 1.00 15.06 ATOM 3618 CG PRO H 184 -12.679 13.484 37.534 1.00 15.56 ATOM 3619 C PRO H 184 -10.444 13.704 40.330 1.00 15.62 ATOM 3620 O PRO H 184 -10.863 12.702 40.860 1.00 17.90 ATOM 3621 N SERH 185 -9.670 14.539 40.949 1.0021.17 ATOM 3623 CA SERH 185 -9.293 14.319 42.331 1.0023.69 ATOM 3624 CB SER H 185 -8.349 15.428 42.797 1.0026.61 ATOM 3625 OG SERH 185 -8.816 16.703 42.357 1.0031.23 ATOM 3627 C SERH 185 -10.519 14.255 43.250 1.0026.32 ATOM 3628 O SERH 185 -10.428 13.761 44.375 1.0029.50 ATOM 3629 N SERH 186 -11.680 14.744 42.806 1.0025.25 ATOM 3631 CA SERH 186 -12.862 14.639 43.647 1.00 25.46 ATOM 3632 CB SERH 186 -14.002 15.509 43.091 1.00 26.27 ATOM 3633 OG SERH 186 -14.525 15.018 41.851 1.0029.82 ATOM 3635 C SERH 186 -13.341 13.173 43.770 1.0024.07 ATOM 3636 O SERH 186 -14.195 12.888 44.575 1.0024.17 ATOM 3637 N THRH 187 -12.784 12.249 42.971 1.0021.70 ATOM 3639 CA THRH 187 -13.287 10.862 42.968 1.00 21.99 ATOM 3640 CB THRH 187 -13.730 10.442 41.555 1.00 20.90 ATOM 3641 OG1 THRH 187 -12.589 10.451 40.677 1.00 18.99 ATOM 3643 CG2 THRH 187 -14.774 11.407 41.023 1.00 18.74 ATOM 3644 C THRH 187 -12.261 9.848 43.494 1.0023.01 ATOM 3645 O THRH 187 -12.477 8.628 43.470 1.0023.61 ATOM 3646 N TRP H 188 -11.140 10.363 43.936 1.00 20.48 ATOM 3648 CA TRP H 188 -10.135 9.556 44.546 1.00 21.24 ATOM 3649 CB TRP H 188 -9.142 8.943 43.524 1.00 15.29 ATOM 3650 CG TRPH 188 -8.158 7.982 44.185 1.00 11.67 ATOM 3651 CD2 TRP H 188 -6.862 8.304 44.783 1.00 8.04 ATOM 3652 CE2TRPH 188 -6.334 7.115 45.311 1.00 8.99 ATOM 3653 CE3 TRP H 188 -6.107 9.487 44.935 1.00 8.90 ATOM 3654 CDI TRP H 188 -8.345 6.630 44.385 1.00 13.61 ATOM 3655 NEI TRP H 188 -7.250 6.131 45.054 1.00 14.95 ATOM 3657 CZ2 TRP H 188 -5.089 7.066 45.964 1.00 12.53 ATOM 3658 CZ3 TRP H 188 -4.885 9.441 45.589 1.00 10.52 ATOM 3659 CH2 TRP H 188 -4.381 8.232 46.093 1.00 12.29 ATOM 3660 C TRP H 188 -9.392 10.449 45.511 1.0020.69 ATOM 3661 O TRP H 188 -8.948 11.534 45.134 1.0020.70 ATOM 3662 N PRO H 189 -9.142 9.960 46.713 1.0020.09 ATOM 3663 CD PRO H 189 -8.341 10.639 47.755 1.00 22.74 ATOM 3664 CA PRO H 189 -9.520 8.612 47.148 1.0020.72 ATOM 3665 CB PROH 189 -8.458 8.316 48.180 1.0022.60 ATOM 3666 CG PRO H 189 -8.350 9.627 48.879 1.0020.47 ATOM 3667 C PRO H 189 -10.913 8.372 47.708 1.0021.08 ATOM 3668 O PROH 189 -11.095 7.388 48.390 1.0022.85 ATOM 3669 N SERH 190 -11.898 9.205 47.432 1.0023.42 ATOM 3671 CA SERH 190 -13.249 8.934 47.944 1.00 21.96 ATOM 3672 CB SERH 190 -14.176 10.098 47.640 1.00 23.31 ATOM 3673 OG SER H 190 -14.449 10.189 46.244 1.00 23.23 ATOM 3675 C SERH 190 -13.824 7.671 47.323 1.00 24.54 ATOM 3676 O SERH 190 -14.591 6.939 47.994 1.00 25.15 ATOM 3677 N GLUH 191 -13.505 7.444 46.003 1.0025.58 ATOM 3679 CA GLU H 191 -13.961 6.235 45.287 1.0023.69 ATOM 3680 CB GLU H 191 -14.754 6.554 43.999 1.00 25.22 ATOM 3681 CG GLU H 191 -15.884 7.588 44.164 1.0028.53 ATOM 3682 CD GLUH 191 -16.949 7.225 45.207 1.0028.30 ATOM 3683 OEI GLU H 191 -16.826 6.164 45.856 1.00 31.06 ATOM 3684 OE2 GLU H 191 -17.917 8.006 45.375 1.00 26.40 ATOM 3685 C GLUH 191 -12.796 5.366 44.937 1.00 23.74 ATOM 3686 O GLUH 191 -11.652 5.824 44.872 1.00 21.49 ATOM 3687 N THRH 192 -13.097 4.115 44.698 1.00 20.79 ATOM 3689 CA THRH 192 -12.071 3.133 44.454 1.00 21.97 ATOM 3690 CB THRH 192 -12.594 1.711 44.731 1.0023.80 ATOM 3691 OGI THRH 192 -13.011 1.628 46.109 1.00 29.80 ATOM 3693 CG2 THRH 192 -11.496 0.677 44.486 1.00 27.22 ATOM 3694 C THRH 192 -11.549 3.169 43.053 1.00 18.87 ATOM 3695 O THRH 192 -12.317 3.268 42.099 1.00 15.94 ATOM 3696 N VAL H 193 -10.239 3.094 42.950 1.00 16.81 ATOM 3698 CA VALH 193 -9.591 2.917 41.671 1.00 16.97 ATOM 3699 CB VALH 193 -8.778 4.194 41.194 1.00 16.54 ATOM 3700 CGI VAL H 193 -7.944 3.904 39.924 1.00 11.61 ATOM 3701 CG2 VAL H 193 -9.780 5.326 40.894 1.00 14.87 ATOM 3702 C VALH 193 -8.725 1.643 41.776 1.00 16.78 WO 99/10379 PCT/GB98/02542 -204 ATOM 3703 0 VAL H 193 -7.889 1.501 42.643 1.00 14.37 ATOM 3704 N THRH 194 -9.032 0.687 40.931 1.00 18.51 ATOM 3706 CA THR H 194 -8.347 -0.574 40.934 1.00 19.26 ATOM 3707 CB THRH 194 -9.341 -1.665 41.316 1.00 19.05 ATOM 3708 OG I THRH 194 -10.064 -1.248 42.490 1.00 22.10 ATOM 3710 CG2 THR H 194 -8.644 -2.983 41.590 1.00 17.95 ATOM 3711 C THRH 194 -7.867 -0.855 39.526 1.00 20.35 ATOM 3712 O THRH 194 -8.574 -0.556 38.558 1.00 18.99 ATOM 3713 N CYS H 195 -6.671 -1.388 39.397 1.0022.03 ATOM 3715 CA CYSH 195 -6.231 -1.850 38.101 1.0021.55 ATOM 3716 CB CYS H 195 -4.827 -1.383 37.796 1.00 22.21 ATOM 3717 SG CYS H 195 -3.518 -2.342 38.560 1.0026.24 ATOM 3718 C CYS H 195 -6.308 -3.366 38.063 1.0020.83 ATOM 3719 O CYS H 195 -6.010 -4.064 39.046 1.0021.96 ATOM 3720 N ASN H 196 -6.718 -3.855 36.927 1.00 19.29 ATOM 3722 CA ASN H 196 -6.918 -5.285 36.687 1.00 16.40 ATOM 3723 CB ASN H 196 -8.285 -5.444 36.035 1.00 16.17 ATOM 3724 CG ASN H 196 -9.245 -4.402 36.544 1.00 13.27 ATOM 3725 ODI ASN H 196 -9.644 -3.478 35.833 1.00 20.19 ATOM 3726 ND2 ASN H 196 -9.601 -4.529 37.793 1.00 11.17 ATOM 3729 C ASN H 196 -5.865 -5.762 35.703 1.00 16.19 ATOM 3730 O ASN H 196 -5.877 -5.335 34.560 1.00 13.42 ATOM 3731 N VALH 197 -4.938 -6.594 36.149 1.00 15.57 ATOM 3733 CA VAL H 197 -3.888 -7.065 35.275 1.00 14.42 ATOM 3734 CB VAL H 197 -2.508 -6.855 35.888 1.00 9.60 ATOM 3735 CG1 VALH 197 -1.452 -7.394 34.943 1.00 7.11 ATOM 3736 CG2 VAL H 197 -2.269 -5.382 36.162 1.00 12.01 ATOM 3737 C VAL H 197 -4.036 -8.543 34.954 1.00 16.35 ATOM 3738 0 VAL H 197 -4.130 -9.370 35.872 1.00 14.56 ATOM 3739 N ALA H 198 -4.039 -8.871 33.646 1.00 17.13 ATOM 3741 CA ALA H 198 -4.125 -10.267 33.222 1.00 16.34 ATOM 3742 CB ALAH 198 -5.306-10.470 32.319 1.00 17.48 ATOM 3743 C ALA H 198 -2.866 -10.680 32.506 1.00 18.98 ATOM 3744 O ALAH 198 -2.326 -9.928 31.688 1.00 18.73 ATOM 3745 N HIS H 199 -2.355 -11.850 32.864 1.00 18.76 ATOM 3747 CA HIS H 199 -1.185-12.410 32.209 1.00 17.07 ATOM 3748 CB HIS H 199 -0.031 -12.507 33.168 1.00 8.69 ATOM 3749 CG HIS H 199 1.221-12.958 32.491 1.00 13.16 ATOM 3750 CD2 HIS H 199 1.798-12.594 31.293 1.00 11.24 ATOM 3751 ND1 HIS H 199 2.094 -13.865 33.052 1.00 12.67 ATOM 3753 CE1 HIS H 199 3.159 -14.054 32.275 1.00 15.05 ATOM 3754 NE2HISH 199 2.979-13.293 31.211 1.00 9.04 ATOM 3756 C HIS H 199 -1.561 -13.804 31.708 1.00 20.77 ATOM 3757 O HISH 199 -1.319-14.821 32.406 1.0022.61 ATOM 3758 N PRO H 200 -2.194-13.865 30.504 1.0023.38 ATOM 3759 CD PRO H 200 -2.490 -12.708 29.606 1.00 23.82 ATOM 3760 CA PRO H 200 -2.642-15.118 29.886 1.0022.74 ATOM 3761 CB PRO H 200 -2.776 -14.742 28.420 1.00 23.09 ATOM 3762 CG PRO H 200 -3.296-13.344 28.504 1.00 23.84 ATOM 3763 C PRO H 200 -1.680-16.267 30.112 1.0022.03 ATOM 3764 O PRO H 200 -2.105 -17.306 30.542 1.00 25.71 ATOM 3765 N ALA H 201 -0.392 -16.059 29.881 1.00 21.74 ATOM 3767 CA ALA H201 0.595 -17.135 30.006 1.00 22.02 ATOM 3768 CB ALA H 201 1.975 -16.601 29.722 1.00 21.34 ATOM 3769 C ALA H 201 0.587-17.840 31.379 1.0025.49 ATOM 3770 O ALA H 201 0.600 -19.086 31.456 1.0027.00 ATOM 3771 N SER H 202 0.590 -17.056 32.458 1.00 23.97 ATOM 3773 CA SER H 202 0.551 -17.620 33.806 1.00 23.02 ATOM 3774 CB SERH 202 1.084 -16.580 34.768 1.00 20.89 ATOM 3775 OG SER H 202 0.362-15.375 34.574 1.00 22.36 ATOM 3777 C SER H 202 -0.886-17.950 34.191 1.0022.44 ATOM 3778 O SER H 202 -1.162-18.406 35.288 1.0024.26 ATOM 3779 N ALA H 203 -1.795 -17.698 33.281 1.00 23.52 ATOM 3781 CA ALA H203 -3.211 -17.834 33.554 1.00 24.82 ATOM 3782 CB ALA H 203 -3.592-19.312 33.629 1.0025.98 ATOM 3783 C ALA H 203 -3.609 -17.062 34.843 1.00 28.71 ATOM 3784 O ALA H 203 -4.389 -17.541 35.682 1.00 33.42 ATOM 3785 N THR H 204 -3.105-15.844 35.003 1.0027.17 ATOM 3787 CA THR H 204 -3.456-15.069 36.191 1.0027.24 ATOM 3788 CB THR H 204 -2.236 -14.718 36.997 1.00 26.73 ATOM 3789 OGI THR H 204 -1.363 -13.914 36.205 1.00 29.32 ATOM 3791 CG2THR H 204 -1.511 -15.983 37.415 1.00 30.85 WO 99/10379 PCT/GB98/02542 -205 ATOM 3792 C THR H 204 -4.184-13.774 35.844 1.0028.10 ATOM 3793 O THR H 204 -4.013 -13.205 34.749 1.00 27.08 ATOM 3794 N LYS H205 -4.988 -13.325 36.796 1.0029.70 ATOM 3796 CA LYS H 205 -5.789 -12.107 36.657 1.00 29.70 ATOM 3797 CB LYS H205 -7.157-12.465 36.050 1.0026.59 ATOM 3798 CG LYS H 205 -8.091 -11.304 35.756 1.00 30.12 ATOM 3799 CD LYS H 205 -7.386 -10.115 35.126 1.0032.29 ATOM 3800 CE LYS H 205 -8.357 -9.001 34.726 1.0028.46 ATOM 3801 NZ LYS H205 -9.140 -9.329 33.482 1.0032.30 ATOM 3805 C LYS H 205 -5.905 -11.468 38.047 1.00 29.50 ATOM 3806 O LYS H 205 -6.666 -11.937 38.903 1.0029.82 ATOM 3807 N VAL H 206 -5.086-10.427 38.273 1.0027.91 ATOM 3809 CA VAL H 206 -5.028 -9.777 39.556 1.00 27.55 ATOM 3810 CB VAL H 206 -3.558 -9.752 40.106 1.0027.51 ATOM 3811 CGI VAL H 206 -2.894-11.102 39.902 1.00 29.90 ATOM 3812 CG2VAL H 206 -2.746 -8.647 39.462 1.0025.31 ATOM 3813 C VAL H 206 -5.608 -8.349 39.561 1.0026.86 ATOM 3814 0 VAL H 206 -5.512 -7.615 38.590 1.0025.39 ATOM 3815 N ASP H 207 -6.237 -7.996 40.683 1.00 27.63 ATOM 3817 CA ASP H 207 -6.741 -6.650 40.923 1.00 25.50 ATOM 3818 CB ASP H 207 -8.170 -6.687 41.430 1.0028.55 ATOM 3819 CG ASP H 207 -9.155 -6.937 40.330 1.0029.54 ATOM 3820 ODI ASP H 207 -8.722 -7.007 39.163 1.00 36.07 ATOM 3821 OD2 ASP H 207 -10.359 -7.064 40.621 1.00 32.67 ATOM 3822 C ASP H 207 -5.917 -6.004 41.988 1.0024.44 ATOM 3823 O ASP H 207 -5.558 -6.682 42.958 1.00 23.66 ATOM 3824 N ALA H208 -5.604 -4.711 41.808 1.0021.43 ATOM 3826 CA ALA H 208 -4.900 -3.949 42.830 1.00 17.91 ATOM 3827 CB ALA H 208 -3.418 -3.791 42.505 1.0020.11 ATOM 3828 C ALA H 208 -5.549 -2.577 43.033 1.00 16.62 ATOM 3829 O ALA H 208 -5.643 -1.754 42.093 1.00 10.62 ATOM 3830 N LYS H 209 -6.048 -2.360 44.266 1.00 16.90 ATOM 3832 CA LYS H 209 -6.670 -1.077 44.630 1.00 15.48 ATOM 3833 CB LYS H 209 -7.658 -1.223 45.807 1.00 10.13 ATOM 3834 CG LYS H 209 -8.246 0.110 46.195 0.50 10.96 ATOM 3835 CD LYS H209 -9.147 -0.015 47.400 0.50 14.26 ATOM 3836 CE LYS H 209 -9.549 1.352 47.908 0.50 12.83 ATOM 3837 NZ LYS H209 -10.556 1.242 48.990 0.50 14.36 ATOM 3841 C LYS H 209 -5.614 -0.010 44.948 1.00 12.92 ATOM 3842 O LYS H 209 -4.631 -0.266 45.641 1.00 10.83 ATOM 3843 N ILEH 210 -5.785 1.178 44.388 1.00 12.54 ATOM 3845 CA ILE H 210 -4.840 2.249 44.672 1.00 14.57 ATOM 3846 CB ILEH 210 -4.665 3.261 43.478 1.00 10.03 ATOM 3847 CG2 ILE H 210 -3.416 4.066 43.683 1.00 9.58 ATOM 3848 CG1 ILEH210 -4.626 2.544 42.096 1.00 11.38 ATOM 3849 CD ILEH210 -3.475 1.591 41.874 1.00 9.16 ATOM 3850 C ILEH210 -5.370 2.972 45.914 1.00 16.98 ATOM 3851 O ILEH210 -6.520 3.462 45.931 1.00 18.38 ATOM 3852 N VAL H 211 -4.544 2.945 46.936 1.00 19.13 ATOM 3854 CA VAL H 211 -4.827 3.524 48.248 1.00 20.34 ATOM 3855 CB VAL H 211 -4.668 2.412 49.313 1.0021.28 ATOM 3856 CGI VAL H 211 -4.884 2.972 50.722 1.0025.89 ATOM 3857 CG2 VAL H 211 -5.624 1.268 49.025 1.00 18.88 ATOM 3858 C VAL H 211 -3.794 4.628 48.528 1.00 19.87 ATOM 3859 0 VAL H 211 -2.612 4.467 48.205 1.0020.58 ATOM 3860 N PRO H212 -4.185 5.764 49.138 1.0021.21 ATOM 3861 CD PRO H 212 -5.552 6.108 49.602 1.00 18.81 ATOM 3862 CA PRO H 212 -3.239 6.879 49.416 1.00 20.72 ATOM 3863 CB PRO H212 -4.124 7.924 50.083 1.00 18.51 ATOM 3864 CG PRO H212 -5.473 7.608 49.550 1.00 18.18 ATOM 3865 C PRO H 212 -2.105 6.454 50.335 1.00 23.63 ATOM 3866 O PRO H 212 -2.305 5.569 51.173 1.0027.07 ATOM 3867 N ARG H 213 -0.907 7.050 50.156 1.0024.57 ATOM 3869 CA ARG H 213 0.202 6.768 51.064 1.0026.72 ATOM 3870 CB ARG H 213 1.594 6.820 50.368 1.0027.15 ATOM 3871 CG ARG H 213 1.881 7.964 49.394 1.00 33.85 ATOM 3872 CD ARG H 213 3.294 7.833 48.788 1.00 33.12 ATOM 3873 NE ARG H 213 3.507 6.488 48.238 1.00 40.88 ATOM 3875 CZ ARG H 213 4.598 5.713 48.492 1.0040.65 ATOM 3876 NHI ARG H 213 4.653 4.479 47.981 1.00 39.58 ATOM 3879 NH2 ARG H 213 5.635 6.171 49.213 1.00 37.54 ATOM 3882 C ARG H 213 0.157 7.700 52.274 1.0027.92 WO 99/10379 PCT/GB98/02542 -206 ATOM 3883 OTI ARG H 213 0.571 7.257 53.377 1.00 31.74 ATOM 3884 OT2 ARG H 213 -0.333 8.846 52.120 1.00 29.09 ATOM 3885 CB ALAP 2 31.230 -8.005 -6.156 1.0023.82 ATOM 3886 C ALA P 2 29.841 -5.882 -6.164 1.00 18.78 ATOM 3887 O ALA P 2 29.790 -5.466 -5.014 1.00 18.94 ATOM 3890 N ALAP 2 32.320 -5.788 -6.175 1.0024.56 ATOM 3892 CA ALA P 2 31.130 -6.567 -6.663 1.00 20.94 ATOM 3893 N ALA P 3 28.823 -5.793 -7.033 1.00 15.73 ATOM 3895 CA ALA P 3 27.589 -5.071 -6.738 1.00 14.42 ATOM 3896 CB ALA P 3 27.052 -4.456 -8.026 1.00 13.90 ATOM 3897 C ALA P 3 26.482 -5.937 -6.142 1.00 14.34 ATOM 3898 O ALA P 3 26.488 -7.186 -6.247 1.00 12.83 ATOM 3899 N PROP 4 25.526 -5.262 -5.467 1.00 12.41 ATOM 3900 CD PROP 4 25.574 -3.831 -5.096 1.00 10.70 ATOM 3901 CA PROP 4 24.357 -5.901 -4.882 1.00 9.09 ATOM 3902 CB PRO P 4 23.878 -4.858 -3.887 1.00 10.23 ATOM 3903 CG PROP 4 24.156 -3.611 -4.622 1.00 10.28 ATOM 3904 C PROP 4 23.348 -6.156 -6.006 1.00 8.50 ATOM 3905 O PROP 4 23.721 -6.099 -7.155 1.00 12.29 ATOM 3906 N ASPP 5 22.112 -6.430 -5.714 1.00 3.44 ATOM 3908 CA ASP P 5 21.183 -6.689 -6.752 1.00 6.24 ATOM 3909 CB ASPP 5 19.985 -7.497 -6.235 1.00 4.87 ATOM 3910 CG ASPP 5 18.944 -7.827 -7.325 1.00 8.73 ATOM 3911 ODI ASPP 5 19.267 -7.802 -8.566 1.00 5.17 ATOM 3912 OD2 ASP P 5 17.791 -8.100 -6.961 1.00 6.00 ATOM 3913 C ASP P 5 20.723 -5.380 -7.397 1.00 11.49 ATOM 3914 O ASP P 5 19.844 -4.711 -6.901 1.00 13.66 ATOM 3915 N THRP 6 21.312 -5.037 -8.536 1.00 13.74 ATOM 3917 CA THRP 6 20.982 -3.798 -9.202 1.00 13.90 ATOM 3918 CB THRP 6 22.265 -3.139 -9.756 1.00 13.32 ATOM 3919 OGITHRP 6 22.906 -3.998-10.711 1.00 19.82 ATOM 3921 CG2THRP 6 23.249 -2.904 -8.618 1.00 17.80 ATOM 3922 C THRP 6 19.950 -3.963-10.307 1.00 13.91 ATOM 3923 0 THRP 6 19.797 -3.065-11.140 1.00 16.59 ATOM 3924 N ARGP 7 19.218 -5.085 -10.346 1.00 12.22 ATOM 3926 CA ARGP 7 18.215 -5.219-11.389 1.00 12.33 ATOM 3927 CB ARG P 7 17.668 -6.648 -11.528 1.00 11.79 ATOM 3928 CG ARG P 7 16.434 -6.709 -12.418 1.00 14.75 ATOM 3929 CD ARG P 7 15.734 -8.048 -12.427 1.00 18.52 ATOM 3930 NE ARGP 7 16.524 -9.011 -13.140 1.0027.19 ATOM 3932 CZ ARGP 7 16.088 -9.705-14.179 1.0026.31 ATOM 3933 NH1 ARG P 7 16.917 -10.544 -14.764 1.00 31.37 ATOM 3936 NH2 ARG P 7 14.850 -9.578 -14.628 1.00 25.93 ATOM 3939 C ARGP 7 17.075 -4.264-11.100 1.00 15.83 ATOM 3940 O ARGP 7 16.766 -4.007 -9.921 1.00 15.84 ATOM 3941 N PROP 8 16.456 -3.660-12.161 1.00 15.86 ATOM 3942 CD PROP 8 16.842 -3.743-13.611 1.00 15.67 ATOM 3943 CA PROP 8 15.351 -2.743 -11.991 1.00 11.60 ATOM 3944 CB PROP 8 15.111 -2.160-13.407 1.00 16.26 ATOM 3945 CG PROP 8 16.425 -2.376-14.102 1.00 12.50 ATOM 3946 C PROP 8 14.108 -3.457-11.438 1.00 15.08 ATOM 3947 O PROP 8 13.722 -4.583 -11.855 1.00 7.39 ATOM 3948 N ALA P 9 13.531 -2.772 -10.458 1.00 14.65 ATOM 3950 CA ALAP 9 12.334 -3.191 -9.773 1.00 16.28 ATOM 3951 CB ALA P 9 12.055 -2.157 -8.654 1.00 13.79 ATOM 3952 C ALAP 9 11.159 -3.193-10.733 1.00 17.17 ATOM 3953 O ALAP 9 11.212 -2.524-11.754 1.00 19.75 ATOM 3954 N PROP 10 10.139 -4.010-10.493 1.00 17.47 ATOM 3955 CD PROP 10 10.126 -5.169 -9.587 1.00 17.04 ATOM 3956 CA PROP 10 8.958 -3.975-11.315 1.0020.33 ATOM 3957 CB PRO P 10 8.080 -5.081 -10.728 1.00 14.66 ATOM 3958 CG PROP 10 8.673 -5.374 -9.408 1.00 18.16 ATOM 3959 C PROP 10 8.307 -2.555 -11.248 1.0023.98 ATOM 3960 OTI PROP 10 8.684 -1.768-10.339 1.0029.12 ATOM 3961 OT2 PRO P 10 7.456 -2.226 -12.120 1.00 32.81 ATOM 3962 OH2 WAT W 1 6.426 14.867 -4.480 1.00 14.28 ATOM 3965 OH2WATW 2 17.532-23.833 -4.169 1.0021.81 ATOM 3968 OH2WATW 3 18.622 4.070 58.161 1.00 6.32 ATOM 3971 OH2 WATW 4 25.532 3.202 -6.059 1.00 13.58 ATOM 3974 OH2 WAT W 5 16.979 -5.181 -7.499 1.00 13.00 ATOM 3977 OH2 WAT W 6 24.971 -23.001 6.210 1.00 30.37 ATOM 3980 OH2 WATW 7 21.577 -21.666 -1.335 1.00 3.40 WO 99/10379 PCT/GB98/02542 -207 ATOM 3983 OH2 WAT W 8 -3.006 -3.287 28.222 1.00 30.92 ATOM 3986 OH2 WAT W 9 28.986-11.555 3.882 1.00 9.44 ATOM 3989 OH2 WAT W 10 -1.960 11.311 49.070 1.00 32.00 ATOM 3992 OH2 WAT W 11 8.423 -21.487 8.622 1.00 13.78 ATOM 3995 OH2 WAT W 12 13.684 27.060 30.432 1.00 39.32 ATOM 3998 OH2 WAT W 13 3.579 4.654 44.811 1.00 13.19 ATOM 4001 OH2 WAT W 14 1.208 15.938 14.282 1.0022.53 ATOM 4004 OH2WATW 15 12.850-17.174 34.625 1.00 19.15 ATOM 4007 OH2 WAT W 16 10.906 -8.230 -12.637 1.00 21.26 ATOM 4010 OH2 WATW 17 8.121 -14.509 21.168 1.0037.92 ATOM 4013 OH2 WAT W 18 21.322 7.473 14.563 1.00 18.86 ATOM 4016 OH2 WAT W 19 -1.612 1.908 47.043 1.00 15.06 ATOM 4019 OH2 WAT W 20 16.800 9.409 27.271 1.00 14.21 ATOM 4022 OH2 WAT W 21 20.637 12.454 -7.154 1.00 16.36 ATOM 4025 OH2 WAT W 22 7.902 -12.529 25.324 1.00 10.64 ATOM 4028 OH2 WAT W 23 -3.580 16.239 24.865 1.00 33.41 ATOM 4031 OH2 WAT W 24 33.184 3.198 45.354 1.00 8.24 ATOM 4034 OH2 WAT W 25 -12.001 -7.854 37.177 1.0026.57 ATOM 4037 OH2WATW 26 25.811 12.550 -5.985 1.0021.74 ATOM 4040 OH2 WAT W 27 -2.669 4.036 26.084 1.00 17.07 ATOM 4043 OH2 WAT W 28 7.584 17.991 41.795 1.00 22.01 ATOM 4046 OH2 WAT W 29 23.880 -14.784 24.981 1.00 8.54 ATOM 4049 OH2 WATW 30 31.343 -2.339 -1.788 1.00 19.31 ATOM 4052 OH2 WAT W 31 17.604 7.877 16.208 1.0028.03 ATOM 4055 OH2 WAT W 32 6.000 -12.613 39.963 1.00 20.30 ATOM 4058 OH2 WAT W 33 5.465 -1.162 17.848 1.0034.15 ATOM 4061 OH2 WAT W 34 11.035 -16.416 36.570 1.00 16.42 ATOM 4064 OH2 WAT W 35 6.472 -14.869 -8.218 1.00 16.12 ATOM 4067 OH2 WAT W 36 9.170 0.957 -2.297 1.00 22.74 ATOM 4070 OH2 WAT W 37 4.454 -4.651 10.416 1.00 20.60 ATOM 4073 OH2 WAT W 38 20.460 -25.521 7.764 1.00 26.25 ATOM 4076 OH2 WAT W 39 7.681 -2.544 1.721 1.00 13.86 ATOM 4079 OH2 WAT W 40 21.029 -25.146 -8.372 1.00 17.33 ATOM 4082 OH2 WAT W 41 14.028 -12.601 28.828 1.00 15.39 ATOM 4085 OH2 WAT W 42 25.022 -8.547 16.118 1.00 16.92 ATOM 4088 OH2WATW 43 18.057 -3.215 49.932 1.0025.44 ATOM 4091 OH2WATW 44 8.711 -22.401 12.910 1.0022.95 ATOM 4094 OH2 WAT W 45 12.338 -7.514 37.880 1.00 26.88 ATOM 4097 OH2 WAT W 46 3.271 -16.775 -4.316 1.00 19.56 ATOM 4100 OH2 WAT W 47 0.541 0.196 50.275 1.00 30.33 ATOM 4103 OH2 WAT W 48 19.110 -25.008 2.771 1.00 5.88 ATOM 4106 OH2 WAT W 49 19.857 5.736 -10.627 1.00 15.25 ATOM 4109 OH2 WAT W 50 27.580 -18.786 1.731 1.00 12.48 ATOM 4112 OH2 WATW 51 18.435 -0.552-10.469 1.0026.95 ATOM 4115 OH2 WAT W 52 14.333 -24.451 3.097 1.0021.65 ATOM 4118 OH2 WAT W 53 15.425 -11.850 25.550 1.00 19.62 ATOM 4121 OH2 WAT W 54 7.024 -3.615 7.466 1.00 10.22 ATOM 4124 OH2 WAT W 55 8.753 -20.576 29.006 1.00 24.86 ATOM 4127 OH2WATW 56 7.171 14.326 47.574 1.0038.64 ATOM 4130 OH2 WAT W 57 27.936 -19.870 -6.755 1.00 5.62 ATOM 4133 OH2 WAT W 58 25.912-19.577 7.753 1.00 10.53 ATOM 4136 OH2 WAT W 59 21.018 -23.427 -10.452 1.00 13.82 ATOM 4139 OH2WATW 60 27.633 -1.667 12.559 1.00 16.07 ATOM 4142 OH2WATW 61 4.313-13.120 12.150 1.0029.58 ATOM 4145 OH2 WAT W 62 10.813 -25.473 15.402 1.00 30.70 ATOM 4148 OH2WATW 63 16.114 5.482 14.710 1.0033.54 ATOM 4151 OH2WATW 64 18.745 -2.391 28.646 1.0029.04 ATOM 4154 OH2 WAT W 65 11.904 1.212 24.223 1.0027.66 ATOM 4157 OH2WATW 66 20.618 0.166 12.936 1.00 13.20 ATOM 4160 OH2 WAT W 67 2.553 2.198 49.034 1.0025.99 ATOM 4163 OH2 WAT W 68 18.383 -9.766 -9.807 1.00 8.99 ATOM 4166 OH2 WAT W 69 12.289 -2.356 38.708 1.00 18.95 ATOM 4169 OH2 WAT W 70 28.530 -9.247 -6.290 1.00 15.87 ATOM 4172 OH2 WAT W 71 7.140 2.348 42.142 1.00 24.77 ATOM 4175 OH2 WATW 72 5.506 -6.185 1.158 1.0025.37 ATOM 4178 OH2 WAT W 73 27.109 -2.182-10.612 1.00 35.24 ATOM 4181 OH2 WAT W 74 23.698 -4.681 9.146 1.00 10.39 ATOM 4184 OH2 WAT W 75 21.899 -8.055 -10.315 1.00 19.23 ATOM 4187 OH2WATW 76 9.190 21.320 27.616 1.0022.97 ATOM 4190 OH2 WAT W 77 -1.064 9.065 47.775 1.00 17.17 ATOM 4193 OH2WATW 78 23.562 -2.845 10.941 1.00 11.39 ATOM 4196 OH2 WAT W 79 14.925 -18.028 -13.375 1.00 38.75 WO 99/10379 PCT/GB98/02542 -208 ATOM 4199 OH2 WAT W 80 18.839 -22.015 -1.607 1.00 16.43 ATOM 4202 OH2 WAT W 81 6.261 9.572 3.405 1.00 10.35 ATOM 4205 OH2 WAT W 82 8.820 -8.947 40.170 1.00 19.41 ATOM 4208 OH2 WAT W 83 14.036 26.574 5.609 1.00 30.50 ATOM 4211 OH2WATW 84 14.876 15.952 -3.144 1.00 14.73 ATOM 4214 OH2 WAT W 85 22.298 -12.049 -10.100 1.00 12.02 ATOM 4217 OH2 WAT W 86 11.954 -24.973 2.713 1.00 17.04 ATOM 4220 OH2 WAT W 87 14.498 -25.610 19.360 1.00 12.97 ATOM 4223 OH2 WAT W 88 26.234 0.908 12.149 1.00 14.84 ATOM 4226 OH2 WATW 89 3.924 18.064 34.080 1.00 14.92 ATOM 4229 OH2 WAT W 90 2.892 -12.720 -0.149 1.00 30.35 ATOM 4232 OH2 WATW 91 21.001 -0.118 -7.935 1.00 11.45 ATOM 4235 OH2 WAT W 92 17.735 4.125 55.330 1.00 23.03 ATOM 4238 OH2 WAT W 93 30.909-19.022 0.239 1.00 18.12 ATOM 4241 OH2 WAT W 94 8.234 0.633 -11.962 1.00 35.87 ATOM 4244 OH2 WATW 95 -0.136 11.812 40.540 1.00 19.09 ATOM 4247 OH2 WAT W 96 25.485 11.712 48.976 1.00 39.93 ATOM 4250 OH2 WAT W 97 13.430 9.938 61.213 1.00 17.48 ATOM 4253 OH2 WATW 98 31.700 7.812 -5.575 1.00 19.58 ATOM 4256 OH2 WAT W 99 15.210 0.308 35.919 1.00 11.83 ATOM 4259 OH2 WAT W 100 -5.288 -15.339 38.902 1.00 16.58 ATOM 4262 OH2 WAT W 101 1.823 -1.479 48.170 1.00 29.29 ATOM 4265 OH2 WAT W 102 -10.016 4.695 47.612 1.0027.17 ATOM 4268 OH2 WAT W 103 6.921 1.076 30.534 1.00 21.69 ATOM 4271 OH2 WAT W 104 20.055 0.656 43.920 1.00 28.97 ATOM 4274 OH2 WAT W 105 6.463 6.212 15.982 1.00 21.65 ATOM 4277 OH2 WAT W 106 13.122 23.767 -4.210 1.00 9.47 ATOM 4280 OH2 WAT W 107 -9.026 -5.522 44.747 1.00 32.78 ATOM 4283 OH2 WAT W 108 29.646 -16.411 0.821 1.00 23.02 ATOM 4286 OH2 WAT W 109 1.361 12.084 -0.538 1.00 27.33 ATOM 4289 OH2 WATW 110 32.303 10.466 -1.708 1.00 22.13 ATOM 4292 OH2 WAT W 111 28.782 -8.621 8.705 1.00 16.73 ATOM 4295 OH2 WAT W 112 24.255 5.940 -10.096 1.00 17.97 ATOM 4298 OH2 WAT W 113 13.049 -12.039 26.267 1.00 17.02 ATOM 4301 OH2 WATW 114 23.675-12.526 16.932 1.00 18.85 ATOM 4304 OH2WATW 115 28.157 2.239-10.357 1.0057.76 ATOM 4307 OH2 WAT W 116 16.617 -26.364 6.730 1.00 14.43 ATOM 4310 OH2WATW 117 25.797 11.257 9.549 1.0020.54 ATOM 4313 OH2 WAT W 118 32.533 10.022 -4.580 1.0028.60 ATOM 4316 OH2 WATW 119 32.447 4.104 -6.869 1.0045.04 ATOM 4319 OH2 WATW 120 -11.651 12.202 46.743 1.0024.53 ATOM 4322 OH2 WAT W 121 2.087 -13.590 -7.699 1.00 34.84 ATOM 4325 OH2 WATW 122 5.697 -8.611 46.172 1.00 13.18 ATOM 4328 OH2 WAT W 123 15.700 -9.174 24.055 1.00 30.63 ATOM 4331 OH2WATW 124 27.694-17.178 14.423 1.00 14.55 ATOM 4334 OH2 WAT W 125 -17.440 6.655 48.327 1.00 17.20 ATOM 4337 OH2 WAT W 126 23.385 -13.611 22.762 1.00 26.67 ATOM 4340 OH2 WAT W 127 17.644 1.422 26.967 1.00 47.02 ATOM 4343 OH2 WAT W 128 14.055 5.694 21.684 1.00 23.91 ATOM 4346 OH2 WAT W 129 -9.680 0.519 31.262 1.00 16.36 ATOM 4349 OH2 WAT W 130 5.299 -6.710 -15.375 1.00 38.16 ATOM 4352 OH2 WATW 131 31.933 8.550 5.211 1.00 13.75 ATOM 4355 OH2 WAT W 132 14.320 -2.736 27.730 1.00 27.48 ATOM 4358 OH2 WAT W 133 34.024 -3.394 1.152 1.00 28.35 ATOM 4361 OH2 WAT W 134 8.372 -8.434 -11.747 1.00 16.01 ATOM 4364 OH2 WAT W 135 21.336 -24.763 25.455 1.00 21.80 ATOM 4367 OH2 WAT W 136 38.405 7.861 2.254 1.00 18.43 ATOM 4370 OH2 WAT W 137 7.136 11.670 49.549 1.00 16.91 ATOM 4373 OH2 WAT W 138 22.371 8.145 -1.106 1.00 3.60 ATOM 4376 OH2 WAT W 139 -0.599 13.866 38.934 1.00 53.27 ATOM 4379 OH2 WATW 140 3.559 20.513 33.347 1.00 25.23 ATOM 4382 OH2 WAT W 141 26.012-21.730 3.659 1.00 8.89 ATOM 4385 OH2 WATW 142 16.747 19.742 12.697 1.00 12.58 ATOM 4388 OH2 WAT W 143 22.905 1.078 -9.223 1.00 33.61 ATOM 4391 OH2 WAT W 144 13.909 -25.966 12.927 1.00 18.24 ATOM 4394 OH2 WAT W 145 -1.880 -13.590 5.375 1.00 22.46 ATOM 4397 OH2 WATW 146 31.991 -3.241 6.307 1.0021.74 ATOM 4400 OH2 WAT W 147 -4.296 -0.541 28.947 1.00 26.69 ATOM 4403 OH2 WAT W 148 21.118-26.880 23.879 1.00 16.34 ATOM 4406 OH2 WATW 149 21.937 7.882-11.795 1.0026.06 ATOM 4409 OH2 WAT W 150 10.669 -24.334 12.632 1.00 21.28 ATOM 4412 OH2 WAT W 151 4.579 13.840 -6.207 1.00 7.70 WO 99/10379 PCT/GB98/02542 -209 ATOM 4415 OH2 WATW 152 30.211 6.160 11.009 1.00 16.94 ATOM 4418 OH2 WATW 153 24.991 -7.106 9.808 1.00 17.58 ATOM 4421 OH2 WAT W 154 11.324 -3.831 36.762 1.00 23.50 ATOM 4424 OH2 WATW 155 -15.285 3.508 41.805 1.00 35.32 ATOM 4427 OH2 WAT W 156 15.119-24.580 -4.682 1.00 18.53 ATOM 4430 OH2 WAT W 157 1.432 -5.537 7.573 1.00 23.51 ATOM 4433 OH2 WAT W 158 -11.941 17.134 41.007 1.00 30.42 ATOM 4436 OH2 WAT W 159 6.869 -18.832 28.614 1.00 19.33 ATOM 4439 OH2 WATW 160 12.995 -0.649 26.156 1.0021.36 ATOM 4442 OH2 WAT W 161 33.416 -5.676 6.213 1.00 23.60 ATOM 4445 OH2 WAT W 162 14.014 24.636 31.376 1.00 36.78 ATOM 4448 OH2 WAT W 163 1.227 -14.938 26.127 1.00 29.62 ATOM 4451 OH2 WAT W 164 24.359 -8.407 -9.667 1.00 15.70 ATOM 4454 OH2 WATW 165 3.110 11.622 42.033 1.0020.46 ATOM 4457 OH2 WAT W 166 10.688 22.835 -4.459 1.00 13.45 ATOM 4460 OH2 WAT W 167 -6.717 -5.186 46.427 1.00 31.64 ATOM 4463 OH2 WATW 168 5.512 -4.116 17.944 1.00 32.66 ATOM 4466 OH2 WATW 169 -20.353 5.803 45.273 1.00 11.80 ATOM 4469 OH2 WAT W 170 18.354 -6.705 -2.499 1.00 3.86 ATOM 4472 OH2 WATW 171 29.217-15.191 3.806 1.00 14.16 ATOM 4475 OH2 WAT W 172 15.303 12.187 54.784 1.00 37.54 ATOM 4478 OH2 WAT W 173 17.118 -25.005 -9.465 1.00 35.04 ATOM 4481 OH2 WAT W 174 8.913 -1.469 19.169 1.00 36.48 ATOM 4484 OH2 WATW 175 32.173 -8.909 4.706 1.00 19.69 ATOM 4487 OH2 WAT W 176 28.509 -17.036 -2.194 1.00 5.68 ATOM 4490 OH2 WAT W 177 6.008 25.018 11.066 1.00 22.81 ATOM 4493 OH2 WAT W 178 20.228 3.127 40.490 1.0023.82 ATOM 4496 OH2 WAT W 179 -0.663 -13.682 40.615 1.00 30.50 ATOM 4499 OH2 WAT W 180 34.602 -2.615 5.839 1.00 21.60 ATOM 4502 OH2 WAT W 181 7.201 4.595 25.466 1.00 15.09 ATOM 4505 OH2 WAT W 182 -4.692 11.606 31.073 1.0020.86 ATOM 4508 OH2 WAT W 183 21.437 -23.456 9.533 1.00 31.82 ATOM 4511 OH2 WAT W 184 13.849 17.698 46.008 1.00 21.96 ATOM 4514 OH2 WATW 185 17.169-16.870-12.443 1.0020.68 ATOM 4517 OH2WATW 186 19.737-21.287-14.670 1.0027.48 ATOM 4520 OH2 WAT W 187 12.044 14.653 15.347 1.00 19.96 ATOM 4523 OH2 WAT W 188 5.432 -6.588 -12.779 1.00 35.66 ATOM 4526 OH2 WAT W 189 4.591 13.681 39.908 1.00 20.33 ATOM 4529 OH2 WAT W 190 21.602 5.346 41.670 1.00 36.13 ATOM 4532 OH2 WAT W 191 29.191 -21.778 7.396 1.00 20.15 ATOM 4535 OH2 WAT W 192 18.030 -9.969 24.699 1.00 36.15 ATOM 4538 OH2 WATW 193 12.481 -28.048 4.388 1.00 18.19 ATOM 4541 OH2 WAT W 194 12.908 10.097 21.791 1.00 38.97 ATOM 4544 OH2 WAT W 195 25.645 8.682 49.741 1.00 27.52 ATOM 4547 OH2 WAT W 196 24.782 10.751 46.034 1.00 10.14 ATOM 4550 OH2 WAT W 197 28.043 -17.199 -7.803 1.00 47.72 ATOM 4553 OH2 WAT W 198 26.889 3.775 48.529 1.00 27.25 ATOM 4556 OH2 WATW 199 15.947 0.435 -1.489 1.00 13.61 ATOM 4559 OH2 WAT W 200 5.673 -3.788 25.327 1.0030.04 ATOM 4562 OH2 WAT W 201 23.387 6.262 13.666 1.00 11.98 ATOM 4565 OH2 WAT W202 4.263 5.267 17.454 1.00 21.77 ATOM 4568 OH2WAT W 203 0.248 -9.252 42.163 1.00 15.59 ATOM 4571 OH2 WAT W 204 25.046 2.931 -8.777 1.00 19.57 ATOM 4574 OH2 WAT W 205 20.186 1.205 -9.775 1.00 34.32 ATOM 4577 OH2 WAT W 206 -3.206 8.912 32.847 1.00 6.08 ATOM 4580 OH2WAT W 207 16.094-17.057 -8.819 1.0022.31 ATOM 4583 OH2 WAT W 208 19.191 8.829 -10.872 1.0042.96 ATOM 4586 OH2 WAT W 209 1.679 -6.926 45.370 1.00 37.43 ATOM 4589 OH2 WAT W 210 -8.601 4.482 49.821 1.0025.82 ATOM 4592 OH2WAT W 211 3.765 -7.431 27.914 1.0027.19 ATOM 4595 OH2 WAT W 212 23.683 -2.641 -13.590 1.00 28.44 ATOM 4598 OH2WAT W 213 29.132 12.371 -6.415 1.0038.04 ATOM 4601 OH2 WAT W 214 23.909 -20.852 2.386 1.00 5.04 ATOM 4604 OH2 WAT W 215 27.253 3.777 37.228 1.00 24.05 ATOM 4607 OH2WAT W 216 5.162-12.163 14.867 1.00 13.79 ATOM 4610 OH2WAT W 217 7.513 3.997 14.327 1.0026.14 ATOM 4613 OH2WAT W 218 20.390 10.391 8.341 1.00 2.00 ATOM 4616 OH2 WAT W 219 17.322 -1.860 -8.500 1.00 18.45 ATOM 4619 OH2WAT W 220 6.864 18.400 -1.951 1.00 18.17 ATOM 4622 OH2 WAT W 221 30.509 -17.379 -8.974 1.00 9.31 ATOM 4625 OH2WAT W 222 1.115 -13.852 28.538 1.00 22.20 ATOM 4628 OH2 WAT W 223 4.674 4.615 24.939 1.00 14.99 WO 99/10379 PCT/GB98/02542 -210 ATOM 4631 OH2 WAT W 224 0.142 17.456 18.372 1.0024.15 ATOM 4634 OH2 WAT W 225 9.859 -27.543 -4.527 1.00 24.23 ATOM 4637 OH2 WAT W 226 17.960 7.797 29.085 1.0026.71 ATOM 4640 OH2WAT W 227 26.317 5.155 -2.166 1.00 7.58 ATOM 4643 OH2 WAT W 228 16.430 -0.855 25.960 1.00 51.29 ATOM 4646 OH2 WAT W 229 8.210-11.591 39.186 1.0024.13 ATOM 4649 OH2 WAT W 230 -0.777 11.927 32.428 1.00 14.96 ATOM 4652 OH2 WAT W 231 10.186 -6.629 43.558 1.0027.57 ATOM 4655 OH2 WAT W 232 0.958 9.102 32.585 1.0024.54 ATOM 4658 OH2 WAT W 233 2.553 11.712 32.867 1.0021.65 ATOM 4661 OH2 WAT W 234 6.680 -0.006 43.521 1.00 10.20 ATOM 4664 OH2 WAT W 235 18.239-24.609 5.252 1.00 11.95 ATOM 4667 OH2 WAT W 236 8.204 6.152 12.418 1.0021.41 ATOM 4670 OH2 WAT W 237 23.369 13.641 49.711 1.00 30.08 ATOM 4673 OH2 WAT W 238 17.028 -7.732 -4.387 1.00 15.78 ATOM 4676 OH2 WAT W 239 30.807 -10.059 6.565 1.0027.21 ATOM 4679 OH2 WAT W 240 -6.711 -6.520 32.290 1.0029.81 ATOM 4682 OH2 WAT W 241 16.555 -12.917 28.106 1.00 36.06 ATOM 4685 OH2 WAT W 242 12.165 -24.551 -7.873 1.00 19.39 ATOM 4688 OH2 WAT W 243 21.126 12.813 35.206 1.00 24.60 ATOM 4691 OH2WAT W 244 18.219 -8.460 20.415 1.0023.62 ATOM 4694 OH2 WAT W 245 20.193 10.009 34.435 1.00 11.86 ATOM 4697 OH2 WAT W 246 29.732 9.455 -8.377 1.00 34.43 ATOM 4700 OH2WAT W 247 13.170 2.121 14.946 1.0024.74 ATOM 4703 OH2 WAT W 248 23.497 -25.395 4.299 1.00 13.44 ATOM 4706 OH2 WAT W 249 14.041 -22.771 -6.627 1.00 17.30 ATOM 4709 OH2 WAT W 250 10.311 0.550 16.295 1.0041.70 ATOM 4712 OH2WAT W 251 13.522 2.361 -9.507 1.0020.28 ATOM 4715 OH2 WAT W 252 13.590-26.409 -3.831 1.00 15.20 ATOM 4718 OH2 WAT W 253 24.905 10.098 -7.007 1.00 29.35 ATOM 4721 OH2 WAT W 254 13.023 -15.944 -13.638 1.00 26.25 ATOM 4724 OH2 WAT W 255 -15.059 5.616 39.922 1.0039.38 ATOM 4727 OH2WAT W 256 16.372 15.953 31.052 1.00 19.01 ATOM 4730 OH2WAT W 257 12.577 -9.193 43.694 1.0020.05 ATOM 4733 OH2 WAT W 258 13.243 -8.179 23.993 1.0041.00 ATOM 4736 OH2 WAT W 259 14.788 0.546-10.706 1.0028.58 ATOM 4739 OH2WAT W 260 19.882 -1.770-13.479 1.0035.11 ATOM 4742 OH2 WAT W 261 31.349 -15.664 -0.850 1.00 26.24 ATOM 4745 OH2 WAT W 262 14.405 -13.078 -16.126 1.00 16.37 ATOM 4748 OH2 WAT W 263 22.733 13.041 16.231 1.0021.47 ATOM 4751 OH2 WAT W 264 16.542 21.606 39.036 1.0026.03 ATOM 4754 OH2 WAT W 265 -6.590 -9.660 42.823 1.00 26.79 ATOM 4757 OH2 WAT W 266 32.784 6.735 -7.882 1.00 26.76 ATOM 4760 OH2 WAT W 267 7.826 14.049 16.469 1.00 18.53 ATOM 4763 OH2 WAT W 268 35.586 1.152 10.429 1.0031.99 ATOM 4766 OH2 WAT W 269 13.273 -7.774 41.272 1.00 27.81 ATOM 4769 OH2 WAT W 270 26.613 -16.200-10.311 1.0024.35 ATOM 4772 OH2WAT W 271 9.380 21.735 36.262 1.0026.21 ATOM 4775 OH2WAT W 272 2.143 -1.862 26.631 1.00 19.18 ATOM 4778 OH2 WAT W 273 4.996 -16.490 24.247 1.00 21.38 ATOM 4781 OH2 WAT W 274 -3.681 11.524 26.326 1.00 32.16 ATOM 4784 OH2WAT W 275 -0.488 20.208 19.551 1.0028.61 ATOM 4787 OH2 WAT W 276 20.222 13.839 -1.397 1.00 6.13 ATOM 4790 OH2 WAT W 277 7.951 8.338 14.092 1.0026.36 ATOM 4793 OH2 WAT W 278 -0.102 -4.099 27.252 1.0022.58 ATOM 4796 OH2 WAT W 279 6.465 -12.539 22.787 1.00 39.32 ATOM 4799 OH2 WAT W 280 27.940 -9.420 11.870 1.0021.31 ATOM 4802 OH2WAT W 281 18.053 -5.607 47.195 1.0028.13 ATOM 4805 OH2 WAT W 282 27.663 -20.337 5.833 1.00 29.05 ATOM 4808 OH2 WAT W 283 7.299 3.352 5.485 1.00 15.35 ATOM 4811 OH2WAT W 284 -1.957 14.568 1.632 1.0030.36 ATOM 4814 OH2WAT W 285 11.592 -3.121 17.799 1.00 19.72 ATOM 4817 OH2 WAT W 286 21.824 -21.684 1.192 1.00 14.10 ATOM 4820 OH2 WAT W287 21.037 -6.590 -2.851 1.00 10.76 ATOM 4823 OH2 WAT W 288 15.218 0.054 17.590 1.0023.02 ATOM 4826 OH2 WAT W 289 17.319 -6.704 54.240 1.0023.81 ATOM 4829 OH2WAT W 290 22.151 -16.769 24.819 1.0026.10 ATOM 4832 OH2WAT W 291 11.461 -1.517-14.214 1.00 17.37 ATOM 4835 OH2 WAT W 292 9.524 1.115 23.430 1.00 18.75 ATOM 4838 OH2 WAT W 293 13.384 17.543 21.896 1.00 32.59 ATOM 4841 OH2 WAT W 294 26.874 -7.117 7.979 1.00 19.34 ATOM 4844 OH2 WAT W 295 21.770 -13.114 -13.708 1.00 29.49 WO 99/10379 PCT/GB98/02542 -211 ATOM 4847 OH2 WAT W 296 11.447 -7.221 35.170 1.00 22.34 ATOM 4850 OH2 WAT W 297 18.712 0.549 -7.664 1.00 16.39 ATOM 4853 OH2 WAT W298 -15.915 3.391 44.805 1.00 37.24 ATOM 4856 OH2 WAT W 299 8.370 -8.297 42.696 1.00 28.38 ATOM 4859 OH2 WAT W 300 2.495 -9.286 23.003 1.00 35.16 ATOM 4862 OH2 WAT W 301 22.017 -7.975 -0.795 1.00 6.11 ATOM 4865 OH2 WAT W 302 21.946 -24.501 2.086 1.00 8.66 ATOM 4868 OH2 WAT W 303 20.054 -25.320 17.657 1.00 9.01 ATOM 4871 OH2 WAT W 304 16.993 -22.098 5.024 1.00 5.97 ATOM 4874 OH2 WAT W 305 5.968 -7.519 14.076 1.0041.33 ATOM 4877 OH2 WATW 306 32.836-13.233 -1.523 1.00 7.51 ATOM 4880 OH2 WAT W 307 -7.127 13.283 28.100 1.00 26.60 ATOM 4883 OH2 WAT W 308 6.091 -19.633 20.653 1.00 34.63 ATOM 4886 OH2 WAT W 309 5.315 8.969 12.397 1.00 19.78 ATOM 4889 OH2 WAT W 310 12.008 2.607 52.956 1.0021.69 ATOM 4892 OH2 WAT W 311 10.006 19.903 41.503 1.0033.05 ATOM 4895 OH2 WAT W 312 13.090 -23.821 -10.159 1.00 36.76 ATOM 4898 OH2 WAT W 313 8.580 -24.171 7.883 1.0034.91 ATOM 4901 OH2WAT W 314 29.016 -9.885 -3.451 1.0029.41 ATOM 4904 OH2 WAT W 315 14.762 -9.284 46.366 1.00 40.86 ATOM 4907 OH2 WAT W 316 7.236 26.011 3.913 1.0028.36 ATOM 4910 OH2WAT W 317 24.009 5.886 39.309 1.00 21.45 ATOM 4913 OH2 WAT W 318 8.878 7.302 16.729 1.0036.71 ATOM 4916 OH2 WAT W 319 -1.085 -7.737 23.652 1.0040.27 ATOM 4919 OH2 WAT W 320 22.737 3.022 44.290 1.0031.90 ATOM 4922 OH2 WAT W 321 11.113 -9.661 22.079 1.0038.45 ATOM 4925 OH2 WAT W 322 22.328 0.316 -12.103 1.0023.98 ATOM 4928 OH2 WAT W 323 6.697 14.352 -9.527 1.00 45.55 ATOM 4931 OH2 WAT W 324 -8.008 -4.161 27.922 1.0029.83 ATOM 4934 OH2 WAT W 325 1.400 17.962 34.791 1.00 30.61 ATOM 4937 OH2 WAT W 326 19.807 10.037 25.470 1.00 33.30 ATOM 4940 OH2WAT W 327 2.104 14.448 12.247 1.0037.11 ATOM 4943 OH2 WAT W 328 15.269 -4.273 25.237 1.0029.17 ATOM 4946 OH2 WAT W 329 12.997 28.118 24.336 1.0030.90 ATOM 4949 OH2 WAT W 330 1.930 -6.058 27.027 1.00 18.90 ATOM 4952 OH2WAT W 331 20.207 17.499 33.744 1.0041.90 ATOM 4955 CD HET I 1 -3.670 11.897 28.662 1.00 34.52 ATOM 4956 CD HET I 2 7.058 -2.556 18.576 1.00 56.55 ATOM 4957 CD HETI 3 -18.942 6.315 46.932 1.0025.08 ATOM 4958 CD HETI 4 31.184-13.965 -2.378 1.00 17.70 ATOM 4959 CD HET I 5 7.095 -7.647 -14.341 1.0057.21 ATOM 4960 CD HET I 6 9.338 21.684 24.997 0.75 48.85 ATOM 4961 CD HET I 7 22.060 5.827 -10.270 0.7526.79 ATOM 4962 CD HET I 8 17.857 -0.598 27.682 0.75 56.40 ATOM 4963 CL CHL I 1 -19.060 3.947 48.046 1.0022.14 ATOM 4964 CL CHL I 2 30.936 -12.255 -4.119 1.0026.88 WO 99/10379 PCT/GB98/02542 -212 Table 2b CRYSTI 42.196 83.729 67.237 90.00 93.30 90.00 P21 SCALE 1 0.023699 0.000000 0.001366 0.00000 SCALE2 0.000000 0.011943 0.000000 0.00000 SCALE3 0.000000 0.000000 0.014897 0.00000 ATOM 1 CB ILEL 3 31.905 -1.198 8.770 1.0022.21 ATOM 2 CG2 ILE L 3 30.889 -2.301 8.558 1.00 27.45 ATOM 3 CGI ILEL 3 31.377 0.099 8.176 1.00 24.21 ATOM 4 CD ILEL 3 32.325 1.259 8.206 1.0025.48 ATOM 5 C ILEL 3 30.908 -0.419 10.822 1.0021.44 ATOM 6 0 ILE L 3 29.898 -1.093 10.998 1.00 20.56 ATOM 9 N ILEL 3 32.310 -2.410 10.862 1.0020.99 ATOM 11 CA ILEL 3 32.131 -1.068 10.239 1.0021.17 ATOM 12 N VALL 4 31.004 0.881 11.110 1.00 20.05 ATOM 14 CA VAL L 4 29.901 1.600 11.728 1.0020.43 ATOM 15 CB VAL L 4 30.358 2.220 13.042 1.00 17.54 ATOM 16 CGI VAL L 4 29.161 2.832 13.761 1.00 19.60 ATOM 17 CG2 VAL L 4 31.020 1.155 13.907 1.00 17.28 ATOM 18 C VALL 4 29.350 2.705 10.834 1.00 20.60 ATOM 19 0 VAL L 4 30.091 3.599 10.429 1.0020.97 ATOM 20 N VALL 5 28.037 2.646 10.593 1.0020.30 ATOM 22 CA VALL 5 27.341 3.599 9.739 1.00 17.97 ATOM 23 CB VALL 5 26.378 2.823 8.824 1.00 17.56 ATOM 24 CG1 VALL 5 25.504 3.752 7.989 1.00 16.02 ATOM 25 CG2 VAL L 5 27.188 1.881 7.940 1.00 17.98 ATOM 26 C VALL 5 26.565 4.566 10.620 1.00 18.99 ATOM 27 0 VALL 5 25.672 4.143 11.342 1.00 18.18 ATOM 28 N THRL 6 26.898 5.849 10.560 1.0017.10 ATOM 30 CA THR L 6 26.267 6.854 11.460 1.00 16.73 ATOM 31 CB THRL 6 27.374 7.687 12.137 1.00 15.12 ATOM 32 OG1 THRL 6 28.157 6.832 12.966 1.00 17.77 ATOM 34 CG2THRL 6 26.816 8.801 12.988 1.00 20.38 ATOM 35 C THRL 6 25.290 7.797 10.746 1.00 15.26 ATOM 36 O THRL 6 25.573 8.275 9.635 1.00 14.60 ATOM 37 N GLN L 7 24.135 8.069 11.409 1.00 14.21 ATOM 39 CA GLN L 7 23.121 9.003 10.914 1.00 9.76 ATOM 40 CB GLN L 7 21.856 8.252 10.519 1.00 8.55 ATOM 41 CG GLN L 7 22.020 7.230 9.405 1.00 3.66 ATOM 42 CD GLN L 7 20.712 6.612 9.060 1.00 4.16 ATOM 43 OE1 GLN L 7 20.484 5.461 9.343 1.00 10.06 ATOM 44 NE2 GLN L 7 19.805 7.378 8.473 1.00 2.55 ATOM 47 C GLN L 7 22.787 9.986 12.037 1.00 12.95 ATOM 48 O GLN L 7 23.200 9.764 13.175 1.00 12.95 ATOM 49 N GLU L 8 22.072 11.070 11.713 1.00 14.59 ATOM 51 CA GLU L 8 21.644 12.044 12.720 1.00 9.44 ATOM 52 CB GLU L 8 21.124 13.317 12.081 1.00 3.83 ATOM 53 CG GLUL 8 22.179 14.142 11.390 1.00 8.12 ATOM 54 CD GLUL 8 22.261 13.874 9.885 1.00 12.60 ATOM 55 OE1 GLU L 8 21.670 12.870 9.432 1.00 8.76 ATOM 56 OE2 GLU L 8 22.936 14.667 9.156 1.00 12.58 ATOM 57 C GLUL 8 20.520 11.439 13.522 1.00 9.97 ATOM 58 O GLUL 8 19.634 10.812 12.954 1.00 10.41 ATOM 59 N SERL 9 20.478 11.677 14.833 1.00 11.56 ATOM 61 CA SERL 9 19.438 11.043 15.608 1.00 8.58 ATOM 62 CB SERL 9 19.742 11.078 17.117 1.00 14.23 WO 99/10379 PCT/GB98/02542 -213 ATOM 63 OG SERL 9 20.274 12.318 17.522 1.0021.30 ATOM 65 C SERL 9 18.090 11.570 15.330 1.00 7.24 ATOM 66 O SERL 9 17.164 10.799 15.246 1.00 6.90 ATOM 67 N ALA L 10 17.922 12.864 15.189 1.00 6.82 ATOM 69 CA ALA L 10 16.587 13.364 14.882 1.00 6.68 ATOM 70 CB ALA L 10 15.774 13.542 16.158 1.00 9.20 ATOM 71 C ALA L 10 16.692 14.689 14.233 1.00 6.99 ATOM 72 O ALA L 10 17.644 15.397 14.502 1.00 8.81 ATOM 73 N LEUL 11 15.711 15.033 13.431 1.00 7.46 ATOM 75 CA LEU L 11 15.669 16.344 12.794 1.00 6.63 ATOM 76 CB LEU L 11 16.167 16.277 11.323 1.00 10.52 ATOM 77 CG LEUL 11 17.504 15.576 11.023 1.00 10.17 ATOM 78 CDI LEUL 11 17.757 15.548 9.520 1.00 8.53 ATOM 79 CD2 LEU L 11 18.639 16.275 11.718 1.00 7.59 ATOM 80 C LEUL 11 14.217 16.796 12.773 1.00 5.60 ATOM 81 O LEUL 11 13.341 15.965 12.677 1.00 7.61 ATOM 82 N THRL 12 13.973 18.114 12.826 1.00 4.15 ATOM 84 CA THRL 12 12.609 18.685 12.814 1.00 6.68 ATOM 85 CB THRL 12 12.361 19.471 14.143 1.00 10.20 ATOM 86 OG1 THRL 12 12.509 18.579 15.267 1.00 10.18 ATOM 88 CG2THRL 12 10.975 20.098 14.149 1.00 4.50 ATOM 89 C THRL 12 12.461 19.702 11.663 1.00 9.42 ATOM 90 O THRL 12 13.361 20.537 11.422 1.00 11.76 ATOM 91 N THRL 13 11.347 19.705 11.003 1.00 12.34 ATOM 93 CA THRL 13 11.179 20.647 9.945 1.00 13.42 ATOM 94 CB THRL 13 11.707 20.011 8.610 1.00 15.26 ATOM 95 OG1 THRL 13 11.997 21.027 7.647 1.00 19.73 ATOM 97 CG2THRL 13 10.696 19.059 8.027 1.00 15.31 ATOM 98 C THRL 13 9.719 21.052 9.816 1.00 13.88 ATOM 99 O THRL 13 8.787 20.272 10.151 1.00 12.15 ATOM 100 N SERL 14 9.479 22.283 9.368 1.00 8.75 ATOM 102 CA SERL 14 8.124 22.660 9.114 1.00 10.75 ATOM 103 CB SERL 14 7.950 24.194 9.110 1.00 15.90 ATOM 104 OG SERL 14 8.798 24.824 10.110 1.00 21.10 ATOM 106 C SERL 14 7.802 22.100 7.778 1.00 10.99 ATOM 107 O SERL 14 8.697 21.878 6.976 1.00 10.06 ATOM 108 N PROL 15 6.561 21.792 7.514 1.00 11.57 ATOM 109 CD PROL 15 5.423 21.907 8.418 1.00 11.51 ATOM 110 CA PROL 15 6.202 21.253 6.217 1.00 13.73 ATOM 111 CB PROL 15 4.703 20.978 6.340 1.00 12.67 ATOM 112 CG PROL 15 4.267 21.855 7.461 1.00 13.25 ATOM 113 C PROL 15 6.559 22.283 5.121 1.00 15.44 ATOM 114 O PROL 15 6.623 23.473 5.418 1.00 14.98 ATOM 115 N GLY L 16 6.852 21.807 3.898 1.00 12.73 ATOM 117 CA GLYL 16 7.189 22.698 2.804 1.00 11.86 ATOM 118 C GLYL 16 8.654 23.047 2.741 1.00 11.99 ATOM 119 O GLYL 16 9.108 23.638 1.781 1.00 16.69 ATOM 120 N GLU L 17 9.412 22.738 3.747 1.00 10.28 ATOM 122 CA GLU L 17 10.807 23.015 3.671 1.00 8.33 ATOM 123 CB GLUL 17 11.328 23.510 5.013 1.00 6.44 ATOM 124 CG GLU L 17 10.669 24.816 5.440 1.00 11.47 ATOM 125 CD GLU L 17 10.780 25.884 4.351 1.00 5.30 ATOM 126 OE1 GLU L 17 11.953 26.232 3.965 1.00 6.09 ATOM 127 OE2 GLUL 17 9.701 26.346 3.902 1.00 7.10 ATOM 128 C GLU L 17 11.560 21.779 3.226 1.00 8.34 ATOM 129 O GLU L 17 11.006 20.676 3.238 1.00 10.48 WO 99/10379 PCT/GB98/02542 -214 ATOM 130 N THRL 18 12.825 21.968 2.878 1.00 7.25 ATOM 132 CA THRL 18 13.676 20.874 2.418 1.00 6.74 ATOM 133 CB THRL 18 14.569 21.384 1.242 1.00 3.14 ATOM 134 OGI THRL 18 13.715 21.629 0.088 1.00 2.24 ATOM 136 CG2 THRL 18 15.708 20.416 0.919 1.00 5.50 ATOM 137 C THRL 18 14.579 20.429 3.555 1.00 5.28 ATOM 138 O THRL 18 15.121 21.267 4.286 1.00 4.15 ATOM 139 N VALL 19 14.815 19.129 3.652 1.00 5.05 ATOM 141 CA VAL L 19 15.714 18.598 4.666 1.00 6.85 ATOM 142 CB VALL 19 14.949 17.763 5.781 1.00 8.11 ATOM 143 CGI VAL L 19 14.478 18.604 6.951 1.00 12.22 ATOM 144 CG2 VAL L 19 13.748 17.040 5.167 1.00 11.25 ATOM 145 C VAL L 19 16.693 17.624 4.009 1.00 7.00 ATOM 146 0 VALL 19 16.323 16.880 3.113 1.00 8.38 ATOM 147 N THRL 20 17.894 17.605 4.503 1.00 7.91 ATOM 149 CA THRL 20 18.852 16.632 4.094 1.00 10.04 ATOM 150 CB THRL 20 20.042 17.279 3.312 1.00 8.38 ATOM 151 OG1 THRL 20 19.537 17.742 2.053 1.00 10.18 ATOM 153 CG2THRL 20 21.179 16.295 3.071 1.00 7.29 ATOM 154 C THRL 20 19.360 15.859 5.320 1.00 10.78 ATOM 155 O THRL 20 19.729 16.451 6.353 1.00 14.77 ATOM 156 N LEUL 21 19.296 14.530 5.192 1.00 8.97 ATOM 158 CA LEUL 21 19.814 13.586 6.162 1.00 5.71 ATOM 159 CB LEUL 21 18.807 12.431 6.310 1.00 7.30 ATOM 160 CG LEUL 21 17.445 12.710 6.929 1.00 3.52 ATOM 161 CD1 LEUL 21 16.597 13.551 5.999 1.00 12.30 ATOM 162 CD2LEUL 21 16.737 11.422 7.224 1.00 5.61 ATOM 163 C LEUL 21 21.092 13.017 5.599 1.00 5.00 ATOM 164 O LEUL 21 21.132 12.728 4.388 1.00 6.66 ATOM 165 N THRL 22 22.136 12.830 6.414 1.00 4.47 ATOM 167 CA THRL 22 23.353 12.205 5.913 1.00 8.68 ATOM 168 CB THRL 22 24.584 13.092 6.055 1.00 8.60 ATOM 169 OGI THRL 22 24.895 13.288 7.446 1.00 13.20 ATOM 171 CG2 THRL 22 24.361 14.408 5.365 1.00 12.92 ATOM 172 C THRL 22 23.656 10.817 6.538 1.00 12.45 ATOM 173 O THRL 22 23.039 10.375 7.556 1.00 12.78 ATOM 174 N CYS L 23 24.623 10.165 5.949 1.00 9.70 ATOM 176 CA CYS L 23 24.969 8.822 6.322 1.00 12.79 ATOM 177 CB CYSL 23 24.119 7.903 5.457 1.00 11.70 ATOM 178 SG CYSL 23 24.572 6.174 5.429 1.00 14.38 ATOM 179 C CYSL 23 26.443 8.613 6.089 1.00 11.83 ATOM 180 O CYS L 23 26.903 8.673 4.959 1.00 13.63 ATOM 181 N ARGL 24 27.216 8.399 7.154 1.00 13.74 ATOM 183 CA ARG L 24 28.651 8.235 6.975 1.00 15.34 ATOM 184 CB ARG L 24 29.459 9.273 7.740 1.00 17.58 ATOM 185 CG ARG L 24 29.196 9.359 9.212 1.0023.61 ATOM 186 CD ARG L 24 30.230 10.251 9.878 1.00 27.66 ATOM 187 NE ARG L 24 31.602 9.792 9.607 1.00 30.74 ATOM 189 CZ ARGL 24 32.571 10.611 9.199 0.01 28.45 ATOM 190 NH1 ARG L 24 33.788 10.139 8.972 0.01 28.77 ATOM 193 NH2 ARG L 24 32.325 11.905 9.015 0.01 27.96 ATOM 196 C ARG L 24 29.134 6.869 7.335 1.00 16.36 ATOM 197 O ARG L 24 28.469 6.140 8.083 1.00 15.58 ATOM 198 N SERL 25 30.284 6.522 6.765 1.00 14.90 ATOM 200 CA SERL 25 30.913 5.239 7.014 1.00 15.33 ATOM 201 CB SERL 25 31.289 4.603 5.681 1.00 20.16 WO 99/10379 PCT/GB98/02542 -215 ATOM 202 OG SER L 25 32.145 3.490 5.853 1.00 23.32 ATOM 204 C SER L 25 32.156 5.467 7.879 1.00 14.75 ATOM 205 O SERL 25 32.869 6.421 7.673 1.00 16.11 ATOM 206 N SERL 26 32.385 4.616 8.864 1.00 15.20 ATOM 208 CA SERL 26 33.552 4.747 9.736 1.00 19.00 ATOM 209 CB SERL 26 33.376 3.841 10.960 1.00 16.96 ATOM 210 OG SERL 26 33.203 2.482 10.552 1.00 19.34 ATOM 212 C SER L 26 34.856 4.349 9.012 1.00 19.93 ATOM 213 O SER L 26 35.939 4.489 9.559 1.00 23.14 ATOM 214 N THR L 27 34.761 3.836 7.800 1.00 20.53 ATOM 216 CA THRL 27 35.952 3.358 7.128 1.00 19.87 ATOM 217 CB THRL 27 35.633 2.079 6.411 1.00 21.22 ATOM 218 OGI THRL 27 34.457 2.255 5.626 1.00 24.06 ATOM 220 CG2 THRL 27 35.388 0.990 7.430 1.0023.05 ATOM 221 C THRL 27 36.520 4.385 6.163 1.00 19.65 ATOM 222 O THRL 27 37.711 4.370 5.825 1.0020.98 ATOM 223 N GLY L 27A 35.672 5.287 5.721 1.0020.47 ATOM 225 CA GLY L 27A 36.115 6.334 4.835 1.00 15.37 ATOM 226 C GLY L 27A 34.954 6.903 4.102 1.00 14.56 ATOM 227 O GLY L 27A 33.832 6.766 4.539 1.00 16.44 ATOM 228 N ALA L 27B 35.225 7.549 2.975 1.00 14.44 ATOM 230 CA ALA L 27B 34.181 8.166 2.158 1.00 13.84 ATOM 231 CB ALAL 27B 34.819 8.849 0.926 1.00 10.44 ATOM 232 C ALA L 27B 33.160 7.161 1.671 1.00 14.20 ATOM 233 O ALA L 27B 33.516 6.038 1.285 1.00 16.84 ATOM 234 N VALL 27C 31.911 7.559 1.666 1.00 12.61 ATOM 236 CA VALL 27C 30.898 6.761 1.026 1.00 14.17 ATOM 237 CB VALL 27C 29.531 7.067 1.621 1.00 13.42 ATOM 238 CGI VAL L 27C 28.472 6.199 0.983 1.00 14.92 ATOM 239 CG2VALL 27C 29.592 6.824 3.116 1.00 14.29 ATOM 240 C VAL L 27C 30.907 7.097 -0.478 1.00 16.22 ATOM 241 0 VAL L 27C 30.841 8.282 -0.851 1.00 16.42 ATOM 242 N THRL 28 31.067 6.061 -1.325 1.00 15.73 ATOM 244 CA THRL 28 31.082 6.232 -2.803 1.00 14.38 ATOM 245 CB THR L 28 32.401 5.745 -3.445 1.00 12.94 ATOM 246 OGI THR L 28 32.448 4.336 -3.415 1.00 13.65 ATOM 248 CG2 THR L 28 33.606 6.278 -2.713 1.00 11.90 ATOM 249 C THR L 28 29.940 5.448 -3.447 1.00 12.92 ATOM 250 O THRL 28 29.134 4.821 -2.760 1.00 9.64 ATOM 251 N THRL 29 29.859 5.480 -4.763 1.00 12.65 ATOM 253 CA THR L 29 28.776 4.795 -5.453 1.00 14.40 ATOM 254 CB THR L 29 28.778 5.093 -6.972 1.00 15.28 ATOM 255 OGI THRL 29 30.119 4.879 -7.479 1.00 16.73 ATOM 257 CG2 THR L 29 28.322 6.530 -7.249 1.00 16.74 ATOM 258 C THRL 29 28.891 3.296 -5.273 1.00 14.04 ATOM 259 O THRL 29 27.922 2.566 -5.455 1.00 17.19 ATOM 260 N SERL 30 30.066 2.849 -4.912 1.00 14.83 ATOM 262 CA SERL 30 30.284 1.440 -4.697 1.00 16.69 ATOM 263 CB SERL 30 31.769 1.177 -4.630 1.00 18.52 ATOM 264 OG SER L 30 32.359 1.484 -5.874 1.00 22.73 ATOM 266 C SERL 30 29.621 0.945 -3.416 1.00 18.22 ATOM 267 O SERL 30 29.584 -0.237 -3.168 1.00 17.69 ATOM 268 N ASN L 31 29.127 1.846 -2.590 1.00 16.05 ATOM 270 CA ASN L 31 28.449 1.434 -1.355 1.00 12.29 WO 99/10379 PCT/GB98/02542 -216 ATOM 271 CB ASN L 31 28.704 2.472 -0.271I 1.00 9.73 ATOM 272 CG ASN L 31 30.112 2.426 0.212 1.00 5.99 ATOM 273 ODI ASN L 31 30.847 3.384 0.091 1.00 9.76 ATOM 274 ND2 ASN L 31 30.523 1.324 0.761 1.00 3.79 ATOM 277 C ASN L 31 26.972 1.276 -1.580 1.00 10.21 ATOM 278 O ASN L 31 26.222 0.938 -0.658 1.00 9.59 ATOM 279 N TYRL 32 26.555 1.527 -2.830 1.00 8.64 ATOM 281 CA TYRL 32 25.160 1.473 -3.217 1.00 7.71 ATOM 282 CB TYRL 32 24.818 0.076 -3.775 1.00 11.29 ATOM 283 CG TYRL 32 25.710 -0.373 -4.931 1.00 11.41 ATOM 284 CDI TYRL 32 27.010 -0.830 -4.688 1.00 14.39 ATOM 285 CEl TYRL 32 27.859 -1.197 -5.716 1.00 14.44 ATOM 286 CD2 TYR L 32 25.282 -0.310 -6.262 1.00 17.67 ATOM 287 CE2TYRL 32 26.131 -0.680 -7.329 1.00 11.36 ATOM 288 CZ TYRL 32 27.425 -1.114 -7.045 1.00 17.13 ATOM 289 OH TYRL 32 28.323 -1.410 -8.087 1.0021.48 ATOM 291 C TYRL 32 24.203 1.855 -2.063 1.00 11.23 ATOM 292 O TYR L 32 23.269 1.105 -1.741 1.00 6.50 ATOM 293 N ALA L 33 24.408 3.053 -1.461 1.00 11.42 ATOM 295 CA ALAL 33 23.576 3.476 -0.310 1.00 11.19 ATOM 296 CB ALAL 33 23.873 4.918 0.090 1.00 10.80 ATOM 297 C ALAL 33 22.086 3.359 -0.549 1.00 10.34 ATOM 298 O ALA L 33 21.603 3.857 -1.555 1.00 8.45 ATOM 299 N ASNL 34 21.357 2.711 0.404 1.00 7.12 ATOM 301 CA ASN L 34 19.892 2.659 0.373 1.00 5.84 ATOM 302 CB ASNL 34 19.358 1.247 0.571 1.00 3.46 ATOM 303 CG ASN L 34 19.466 0.414 -0.680 1.00 7.07 ATOM 304 ODI ASN L 34 18.468 -0.071 -1.209 1.00 5.20 ATOM 305 ND2 ASN L 34 20.684 0.244 -1.154 1.00 5.40 ATOM 308 C ASNL 34 19.299 3.525 1.459 1.00 5.10 ATOM 309 O ASN L 34 19.956 3.794 2.431 1.00 6.58 ATOM 310 N TRPL 35 18.064 3.959 1.259 1.00 5.01 ATOM 312 CA TRPL 35 17.332 4.692 2.283 1.00 6.70 ATOM 313 CB TRPL 35 17.171 6.216 1.946 1.00 7.73 ATOM 314 CG TRPL 35 18.477 6.997 1.949 1.00 7.11 ATOM 315 CD2TRPL 35 19.085 7.645 3.093 1.00 8.09 ATOM 316 CE2TRPL 35 20.339 8.113 2.703 1.00 5.38 ATOM 317 CE3 TRPL 35 18.678 7.870 4.430 1.00 10.50 ATOM 318 CDI TRPL 35 19.367 7.124 0.911 1.00 4.99 ATOM 319 NEl TRPL 35 20.473 7.778 1.362 1.00 6.98 ATOM 321 CZ2 TRPL 35 21.221 8.799 3.589 1.00 5.76 ATOM 322 CZ3 TRP L 35 19.551 8.549 5.297 1.00 6.19 ATOM 323 CH2TRPL 35 20.810 9.005 4.874 1.00 3.95 ATOM 324 C TRPL 35 16.000 4.031 2.417 1.00 6.29 ATOM 325 O TRPL 35 15.325 3.778 1.405 1.00 6.53 ATOM 326 N VALL 36 15.672 3.703 3.666 1.00 5.99 ATOM 328 CA VAL L 36 14.478 2.972 4.045 1.00 5.23 ATOM 329 CB VAL L 36 14.813 1.554 4.655 1.00 6.23 ATOM 330 CGI VAL L 36 13.506 0.851 5.082 1.00 2.37 ATOM 331 CG2 VAL L 36 15.564 0.684 3.614 1.00 3.99 ATOM 332 C VALL 36 13.691 3.768 5.084 1.00 4.86 ATOM 333 0 VAL L 36 14.248 4.303 6.022 1.00 7.07 ATOM 334 N GLN L 37 12.399 3.809 4.899 1.00 5.26 ATOM 336 CA GLNL 37 11.519 4.533 5.779 1.00 10.98 ATOM 337 CB GLN L 37 10.525 5.309 4.957 1.00 10.61 ATOM 338 CG GLN L 37 9.741 6.290 5.782 1.00 10.14 WO 99/10379 PCT/GB98/02542 -217 ATOM 339 CD GLN L 37 8.607 6.827 4.999 1.00 15.44 ATOM 340 OE1 GLN L 37 7.788 6.066 4.504 1.00 18.50 ATOM 341 NE2 GLN L 37 8.549 8.139 4.859 1.00 15.77 ATOM 344 C GLNL 37 10.722 3.614 6.683 1.00 11.84 ATOM 345 O GLN L 37 10.126 2.656 6.211 1.00 15.29 ATOM 346 N GLU L 38 10.675 3.956 7.976 1.00 13.42 ATOM 348 CA GLU L 38 9.853 3.223 8.919 1.00 12.58 ATOM 349 CB GLU L 38 10.677 2.724 10.118 1.00 12.59 ATOM 350 CG GLU L 38 9.839 1.948 11.160 1.00 11.75 ATOM 351 CD GLU L 38 10.618 1.491 12.372 1.00 9.26 ATOM 352 OEI GLU L 38 11.747 1.908 12.546 1.00 12.30 ATOM 353 OE2 GLU L 38 10.081 0.690 13.157 1.00 17.41 ATOM 354 C GLU L 38 8.713 4.100 9.455 1.00 14.00 ATOM 355 O GLU L 38 8.958 5.094 10.163 1.00 12.02 ATOM 356 N LYS L 39 7.484 3.742 9.126 1.00 13.36 ATOM 358 CA LYS L 39 6.358 4.424 9.695 1.00 15.90 ATOM 359 CB LYS L 39 5.348 4.743 8.626 1.00 14.39 ATOM 360 CG LYS L 39 5.777 5.942 7.806 1.00 15.78 ATOM 361 CD LYS L 39 4.645 6.445 6.935 1.00 22.14 ATOM 362 CE LYS L 39 5.167 7.426 5.888 1.0025.73 ATOM 363 NZ LYS L 39 4.104 7.912 4.945 1.0027.82 ATOM 367 C LYS L 39 5.728 3.607 10.852 1.00 20.86 ATOM 368 O LYS L 39 5.778 2.341 10.896 1.00 18.39 ATOM 369 N PROL 40 5.134 4.308 11.828 1.0025.47 ATOM 370 CD PROL 40 4.954 5.763 11.895 1.0028.62 ATOM 371 CA PROL 40 4.505 3.681 12.975 1.00 28.32 ATOM 372 CB PROL 40 3.543 4.770 13.526 1.0028.73 ATOM 373 CG PROL 40 3.563 5.834 12.480 1.00 30.27 ATOM 374 C PRO L 40 3.804 2.365 12.616 1.00 28.70 ATOM 375 O PRO L 40 2.930 2.301 11.709 1.0025.53 ATOM 376 N ALA L 41 4.290 1.328 13.333 1.00 30.46 ATOM 378 CA ALAL 41 3.831 -0.059 13.244 1.00 28.13 ATOM 379 CB ALA L 41 2.435 -0.174 12.622 1.00 29.92 ATOM 380 C ALA L 41 4.819 -0.905 12.481 1.00 24.45 ATOM 381 O ALA L 41 4.434 -1.889 11.871 1.00 26.51 ATOM 382 N HISL 42 6.101 -0.531 12.505 1.0022.07 ATOM 384 CA HISL 42 7.107 -1.346 11.839 1.0020.06 ATOM 385 CB HIS L 42 7.123 -2.746 12.437 1.0020.43 ATOM 386 CG HIS L 42 7.624 -2.738 13.806 1.00 17.71 ATOM 387 CD2 HIS L 42 6.999 -2.731 15.013 1.00 17.56 ATOM 388 NDI HIS L 42 8.945 -2.550 14.068 1.00 21.55 ATOM 390 CE1 HIS L 42 9.186 -2.412 15.347 1.00 19.46 ATOM 391 NE2 HIS L 42 8.025 -2.519 15.929 1.00 17.49 ATOM 393 C HISL 42 6.823 -1.474 10.366 1.0021.88 ATOM 394 O HIS L 42 6.999 -2.549 9.799 1.00 22.22 ATOM 395 N LEU L 43 6.326 -0.408 9.750 1.00 20.03 ATOM 397 CA LEUL 43 6.057 -0.452 8.337 1.00 20.01 ATOM 398 CB LEU L 43 4.844 0.394 8.018 1.00 24.58 ATOM 399 CG LEU L 43 3.587 0.058 8.828 1.00 27.32 ATOM 400 CD1 LEU L 43 2.565 1.181 8.678 1.00 26.38 ATOM 401 CD2 LEU L 43 3.027 -1.328 8.423 1.00 24.37 ATOM 402 C LEU L 43 7.264 0.087 7.623 1.00 18.27 ATOM 403 O LEUL 43 7.576 1.266 7.750 1.00 18.64 ATOM 404 N PHEL 44 7.966 -0.785 6.919 1.00 17.14 ATOM 406 CA PHEL 44 9.184 -0.395 6.237 1.00 13.89 ATOM 407 CB PHE L 44 10.265 -1.388 6.547 1.00 10.76 WO 99/10379 PCT/GB98/02542 -218 ATOM 408 CG PHE L 44 10.846 -1.269 7.917 1.00 8.20 ATOM 409 CDI PHE L 44 10.255 -1.929 8.985 1.00 10.99 ATOM 410 CD2 PHE L 44 12.002 -0.541 8.127 1.00 13.17 ATOM 411 CEI PHE L 44 10.796 -1.866 10.252 1.00 11.48 ATOM 412 CE2 PHE L 44 12.566 -0.471 9.394 1.00 12.05 ATOM 413 CZ PHEL 44 11.954 -1.135 10.462 1.00 12.67 ATOM 414 C PHEL 44 8.986 -0.319 4.731 1.00 14.13 ATOM 415 O PHEL 44 8.261 -1.106 4.146 1.00 14.69 ATOM 416 N THRL 45 9.655 0.615 4.100 1.00 14.63 ATOM 418 CA THR L 45 9.527 0.762 2.686 1.00 12.14 ATOM 419 CB THRL 45 8.316 1.644 2.361 1.00 14.73 ATOM 420 OGI THRL 45 8.095 1.663 0.958 1.0025.05 ATOM 422 CG2 THR L 45 8.557 3.064 2.814 1.00 19.97 ATOM 423 C THRL 45 10.787 1.386 2.187 1.00 11.69 ATOM 424 O THRL 45 11.314 2.243 2.824 1.00 9.53 ATOM 425 N GLYL 46 11.317 0.861 1.096 1.00 11.34 ATOM 427 CA GLYL 46 12.535 1.388 0.532 1.00 7.20 ATOM 428 C GLY L 46 12.250 2.581 -0.326 1.00 7.78 ATOM 429 O GLY L 46 11.266 2.582 -1.130 1.00 10.42 ATOM 430 N LEU L 47 13.086 3.592 -0.168 1.00 7.54 ATOM 432 CA LEU L 47 12.912 4.859 -0.884 1.00 7.47 ATOM 433 CB LEU L 47 13.083 6.035 0.087 1.00 6.90 ATOM 434 CG LEU L 47 12.285 5.959 1.375 1.00 6.26 ATOM 435 CD1 LEUL 47 12.862 6.905 2.403 1.00 11.14 ATOM 436 CD2 LEU L 47 10.820 6.197 1.085 1.00 2.41 ATOM 437 C LEUL 47 13.940 4.988 -2.015 1.00 5.84 ATOM 438 O LEUL 47 13.563 5.288 -3.139 1.00 8.92 ATOM 439 N ILEL 48 15.209 4.749 -1.675 1.00 9.03 ATOM 441 CA ILE L 48 16.350 4.907 -2.568 1.00 7.03 ATOM 442 CB ILE L 48 17.257 6.079 -2.090 1.00 7.21 ATOM 443 CG2ILEL 48 18.525 6.173 -2.924 1.00 9.51 ATOM 444 CG1 ILE L 48 16.497 7.409 -2.042 1.00 8.82 ATOM 445 CD ILEL 48 16.008 7.937 -3.363 1.00 7.80 ATOM 446 C ILE L 48 17.230 3.640 -2.525 1.00 8.61 ATOM 447 O ILE L 48 17.458 3.073 -1.451 1.00 10.60 ATOM 448 N GLY L 49 17.740 3.224 -3.700 1.00 7.04 ATOM 450 CA GLY L 49 18.702 2.140 -3.794 1.00 2.00 ATOM 451 C GLY L 49 19.833 2.557 -4.709 1.00 7.57 ATOM 452 O GLYL 49 19.696 3.467 -5.544 1.00 14.41 ATOM 453 N GLY L 50 20.957 1.959 -4.582 1.00 9.91 ATOM 455 CA GLYL 50 22.027 2.316 -5.453 1.00 9.21 ATOM 456 C GLY L 50 22.297 3.805 -5.479 1.00 12.31 ATOM 457 O GLYL 50 22.358 4.388 -6.535 1.00 12.48 ATOM 458 N THRL 51 22.456 4.402 -4.305 1.00 10.33 ATOM 460 CA THRL 51 22.787 5.841 -4.140 1.00 12.06 ATOM 461 CB THRL 51 24.098 6.283 -4.882 1.00 11.87 ATOM 462 OG1 THRL 51 25.218 5.449 -4.521 1.00 7.57 ATOM 464 CG2 THRL 51 24.449 7.719 -4.497 1.00 11.63 ATOM 465 C THR L 51 21.668 6.825 -4.481 1.00 11.67 ATOM 466 O THRL 51 21.346 7.664 -3.651 1.00 11.93 ATOM 467 N ASN L 52 21.034 6.712 -5.662 1.00 12.21 ATOM 469 CA ASN L 52 20.063 7.719 -6.076 1.00 13.73 ATOM 470 CB ASN L 52 20.764 8.826 -6.841 1.00 18.43 ATOM 471 CG ASN L 52 21.598 8.273 -7.968 1.0024.37 ATOM 472 ODI ASN L 52 21.193 7.327 -8.623 1.00 22.65 ATOM 473 ND2ASNL 52 22.788 8.821 -8.173 1.0028.21 WO 99/10379 PCT/GB98/02542 -219 ATOM 476 C ASN L 52 18.943 7.197 -6.931 1.00 15.37 ATOM 477 O ASN L 52 18.295 7.964 -7.613 1.00 13.37 ATOM 478 N ASN L 53 18.726 5.906 -6.928 1.00 16.28 ATOM 480 CA ASN L 53 17.637 5.343 -7.691 1.00 17.34 ATOM 481 CB ASN L 53 18.056 3.969 -8.244 1.00 24.00 ATOM 482 CG ASN L 53 17.181 3.420 -9.373 1.0027.36 ATOM 483 ODI ASN L 53 17.664 2.624 -10.199 1.00 33.10 ATOM 484 ND2 ASN L 53 15.903 3.812 -9.439 1.00 31.42 ATOM 487 C ASN L 53 16.409 5.216 -6.784 1.00 17.91 ATOM 488 O ASN L 53 16.369 4.427 -5.870 1.00 18.29 ATOM 489 N ARG L 54 15.431 6.003 -7.032 1.00 15.93 ATOM 491 CA ARG L 54 14.269 5.978 -6.237 1.00 18.87 ATOM 492 CB ARG L 54 13.494 7.239 -6.542 1.0022.33 ATOM 493 CG ARGL 54 12.114 7.315 -5.958 1.0025.55 ATOM 494 CD ARG L 54 11.818 8.740 -5.619 1.0029.54 ATOM 495 NE ARG L 54 12.156 9.611 -6.703 1.0027.82 ATOM 497 CZ ARGL 54 11.305 9.903 -7.653 1.0032.19 ATOM 498 NHI ARG L 54 11.676 10.713 -8.622 1.00 35.27 ATOM 501 NH2 ARG L 54 10.080 9.380 -7.644 1.00 31.58 ATOM 504 C ARG L 54 13.462 4.730 -6.545 1.0021.41 ATOM 505 O ARG L 54 13.238 4.418 -7.734 1.0021.21 ATOM 506 N ALA L 55 13.049 4.008 -5.480 1.0020.79 ATOM 508 CA ALA L 55 12.226 2.802 -5.620 1.00 21.50 ATOM 509 CB ALAL 55 11.976 2.164 -4.253 1.00 18.92 ATOM 510 C ALAL 55 10.925 3.180 -6.285 1.0022.01 ATOM 511 O ALAL 55 10.492 4.311 -6.184 1.0023.44 ATOM 512 N PROL 56 10.249 2.257 -6.952 1.0025.55 ATOM 513 CD PROL 56 10.577 0.805 -7.061 1.0026.77 ATOM 514 CA PRO L 56 9.009 2.580 -7.645 1.0024.82 ATOM 515 CB PRO L 56 8.686 1.274 -8.405 1.0027.53 ATOM 516 CG PRO L 56 9.270 0.215 -7.526 1.0027.71 ATOM 517 C PRO L 56 7.903 3.030 -6.696 1.0025.91 ATOM 518 O PROL 56 7.736 2.500 -5.588 1.0026.27 ATOM 519 N GLY L 57 7.138 4.016 -7.146 1.0026.28 ATOM 521 CA GLY L 57 6.045 4.544 -6.338 1.00 22.74 ATOM 522 C GLY L 57 6.471 5.629 -5.360 1.0020.96 ATOM 523 O GLYL 57 5.654 6.415 -4.928 1.0023.79 ATOM 524 N VAL L 58 7.749 5.670 -4.998 1.0020.25 ATOM 526 CA VALL 58 8.228 6.677 -4.084 1.00 18.53 ATOM 527 CB VAL L 58 9.676 6.383 -3.720 1.00 15.29 ATOM 528 CGI VAL L 58 10.261 7.548 -2.974 1.00 11.07 ATOM 529 CG2 VAL L 58 9.742 5.104 -2.893 1.00 12.65 ATOM 530 C VALL 58 8.120 8.092 -4.688 1.00 22.04 ATOM 531 0 VAL L 58 8.591 8.337 -5.814 1.00 22.18 ATOM 532 N PROL 59 7.523 9.061 -3.910 1.00 21.50 ATOM 533 CD PRO L 59 6.971 8.873 -2.543 1.0020.50 ATOM 534 CA PRO L 59 7.338 10.464 -4.326 1.00 17.94 ATOM 535 CB PRO L 59 6.866 11.147 -3.063 1.00 18.92 ATOM 536 CG PRO L 59 6.066 10.068 -2.423 1.00 18.97 ATOM 537 C PROL 59 8.586 11.100 -4.852 1.00 16.82 ATOM 538 O PROL 59 9.708 10.921 -4.327 1.00 15.46 ATOM 539 N ALA L 60 8.374 11.880 -5.867 1.00 13.05 ATOM 541 CA ALA L 60 9.448 12.535 -6.530 1.00 14.83 ATOM 542 CB ALA L 60 8.866 13.317 -7.685 1.00 14.69 ATOM 543 C ALA L 60 10.238 13.427 -5.574 1.00 13.44 ATOM 544 O ALA L 60 11.412 13.644 -5.782 1.00 12.14 WO 99/10379 PCT/GB98/02542 -220 ATOM 545 N ARG L 61 9.601 13.919 -4.488 1.00 15.30 ATOM 547 CA ARG L 61 10.313 14.815 -3.524 1.00 12.59 ATOM 548 CB ARG L 61 9.351 15.398 -2.478 1.00 11.72 ATOM 549 CG ARG L 61 8.625 14.385 -1.596 1.00 14.79 ATOM 550 CD ARG L 61 7.915 15.063 -0.415 1.00 14.00 ATOM 551 NE ARG L 61 7.241 14.100 0.466 1.00 10.99 ATOM 553 CZ ARGL 61 6.124 13.482 0.102 1.00 11.79 ATOM 554 NHI ARG L 61 5.532 12.600 0.889 1.00 10.75 ATOM 557 NH2 ARG L 61 5.617 13.726 -1.066 1.00 9.70 ATOM 560 C ARG L 61 11.499 14.160 -2.810 1.00 12.82 ATOM 561 O ARG L 61 12.289 14.863 -2.103 1.00 14.41 ATOM 562 N PHEL 62 11.648 12.826 -2.955 1.00 11.27 ATOM 564 CA PHEL 62 12.755 12.125 -2.302 1.00 10.94 ATOM 565 CB PHE L 62 12.288 10.734 -1.773 1.00 9.35 ATOM 566 CG PHEL 62 11.285 10.782 -0.645 1.00 9.62 ATOM 567 CDI PHEL 62 11.712 10.900 0.694 1.00 5.49 ATOM 568 CD2 PHE L 62 9.924 10.700 -0.909 1.00 6.68 ATOM 569 CEI PHEL 62 10.780 10.933 1.709 1.00 2.51 ATOM 570 CE2 PHE L 62 8.998 10.735 0.116 1.00 7.73 ATOM 571 CZ PHEL 62 9.424 10.854 1.425 1.00 4.66 ATOM 572 C PHEL 62 13.913 11.936 -3.265 1.00 9.16 ATOM 573 O PHEL 62 13.679 11.434 -4.344 1.00 8.82 ATOM 574 N SERL 63 15.160 12.336 -2.872 1.00 4.85 ATOM 576 CA SERL 63 16.310 12.117 -3.737 1.00 8.59 ATOM 577 CB SERL 63 16.686 13.360 -4.530 1.00 7.17 ATOM 578 OG SERL 63 17.272 14.327 -3.676 1.00 12.90 ATOM 580 C SERL 63 17.512 11.684 -2.949 1.00 7.30 ATOM 581 O SERL 63 17.714 12.184 -1.861 1.00 9.45 ATOM 582 N GLYL 64 18.284 10.714 -3.503 1.00 5.56 ATOM 584 CA GLY L 64 19.500 10.258 -2.891 1.00 4.07 ATOM 585 C GLY L 64 20.685 10.879 -3.565 1.00 9.49 ATOM 586 O GLYL 64 20.628 11.253 -4.757 1.00 12.20 ATOM 587 N SERL 65 21.761 11.034 -2.869 1.00 6.73 ATOM 589 CA SERL 65 22.876 11.673 -3.482 1.00 9.75 ATOM 590 CB SERL 65 22.603 13.184 -3.669 1.00 8.17 ATOM 591 OG SERL 65 22.777 13.907 -2.443 1.00 10.45 ATOM 593 C SER L 65 24.064 11.432 -2.648 1.00 10.16 ATOM 594 O SERL 65 23.959 10.685 -1.670 1.00 10.96 ATOM 595 N LEUL 66 25.194 11.991 -3.078 1.00 10.68 ATOM 597 CA LEU L 66 26.460 11.858 -2.382 1.00 9.69 ATOM 598 CB LEUL 66 27.453 11.096 -3.303 1.00 13.61 ATOM 599 CG LEU L 66 28.203 9.827 -2.816 1.00 9.87 ATOM 600 CD1 LEUL 66 27.339 8.952 -1.958 1.00 8.09 ATOM 601 CD2 LEU L 66 28.667 9.029 -4.026 1.00 8.69 ATOM 602 C LEUL 66 26.931 13.303 -2.134 1.00 12.92 ATOM 603 O LEU L 66 27.044 14.080 -3.070 1.00 10.87 ATOM 604 N ILEL 67 27.136 13.678 -0.858 1.00 12.45 ATOM 606 CA ILEL 67 27.577 15.035 -0.515 1.00 11.66 ATOM 607 CB ILEL 67 26.479 15.768 0.341 1.00 12.96 ATOM 608 CG2 ILE L 67 26.874 17.196 0.608 1.00 13.30 ATOM 609 CG1 I ILE L 67 25.123 15.753 -0.357 1.00 13.53 ATOM 610 CD ILEL 67 24.013 16.437 0.425 1.00 11.05 ATOM 611 C ILEL 67 28.879 14.904 0.276 1.00 12.31 ATOM 612 O ILEL 67 28.896 14.327 1.350 1.00 13.03 ATOM 613 N GLYL 68 29.987 15.387 -0.260 1.00 13.08 ATOM 615 CA GLY L 68 31.238 15.196 0.431 1.00 12.32 WO 99/10379 PCT/GB98/02542 -221 ATOM 616 C GLY L 68 31.485 13.701 0.579 1.00 17.92 ATOM 617 O GLY L 68 31.193 12.939 -0.379 1.00 16.67 ATOM 618 N ASP L 69 31.987 13.249 1.750 1.00 16.48 ATOM 620 CA ASP L 69 32.247 11.813 1.933 1.00 18.10 ATOM 621 CB ASPL 69 33.366 11.533 2.931 1.0024.05 ATOM 622 CG ASPL 69 34.618 12.344 2.727 1.0031.27 ATOM 623 ODI ASP L 69 35.210 12.318 1.596 1.00 32.40 ATOM 624 OD2 ASP L 69 35.021 13.019 3.724 1.00 39.08 ATOM 625 C ASP L 69 31.040 11.037 2.437 1.00 14.56 ATOM 626 O ASP L 69 31.214 9.924 2.915 1.00 16.00 ATOM 627 N LYSL 70 29.837 11.568 2.319 1.00 11.13 ATOM 629 CA LYS L 70 28.688 10.854 2.852 1.00 11.46 ATOM 630 CB LYS L 70 28.116 11.608 4.037 1.00 11.39 ATOM 631 CG LYS L 70 28.992 11.536 5.269 1.00 18.50 ATOM 632 CD LYS L 70 28.255 12.102 6.467 1.0020.15 ATOM 633 CE LYS L 70 28.208 13.604 6.394 1.0022.74 ATOM 634 NZ LYS L 70 29.587 14.158 6.382 1.0027.69 ATOM 638 C LYS L 70 27.589 10.639 1.872 1.00 10.75 ATOM 639 O LYSL 70 27.473 11.369 0.883 1.00 11.35 ATOM 640 N ALA L 71 26.762 9.623 2.137 1.00 6.32 ATOM 642 CA ALA L 71 25.546 9.487 1.377 1.00 2.44 ATOM 643 CB ALA L 71 25.071 8.044 1.378 1.00 2.00 ATOM 644 C ALA L 71 24.490 10.404 2.020 1.00 6.77 ATOM 645 O ALA L 71 24.528 10.675 3.251 1.00 6.10 ATOM 646 N ALAL 72 23.549 10.888 1.230 1.00 5.00 ATOM 648 CA ALAL 72 22.564 11.807 1.736 1.00 6.21 ATOM 649 CB ALAL 72 23.027 13.252 1.512 1.00 3.82 ATOM 650 C ALAL 72 21.207 11.564 1.102 1.00 4.44 ATOM 651 O ALAL 72 21.089 11.053 -0.049 1.00 6.60 ATOM 652 N LEUL 73 20.183 11.857 1.885 1.00 5.08 ATOM 654 CA LEU L 73 18.796 11.776 1.446 1.00 4.01 ATOM 655 CB LEUL 73 17.970 10.826 2.307 1.00 4.42 ATOM 656 CG LEU L 73 16.498 10.785 1.936 1.00 4.74 ATOM 657 CD1 LEU L 73 16.312 9.970 0.656 1.00 4.42 ATOM 658 CD2 LEU L 73 15.675 10.211 3.083 1.00 8.67 ATOM 659 C LEU L 73 18.191 13.148 1.579 1.00 5.38 ATOM 660 O LEU L 73 18.287 13.764 2.621 1.00 9.62 ATOM 661 N THRL 74 17.593 13.629 0.537 1.00 7.72 ATOM 663 CA THRL 74 16.998 14.928 0.562 1.00 6.80 ATOM 664 CB THRL 74 17.695 15.896 -0.460 1.00 9.87 A'IOM 665 OGI THRL 74 19.076 16.149 -0.017 1.00 4.69 ATOM 667 CG2 THR L 74 16.936 17.208 -0.559 1.00 4.65 ATOM 668 C THRL 74 15.571 14.855 0.277 1.00 7.31 ATOM 669 O THRL 74 15.153 14.227 -0.676 1.00 6.60 ATOM 670 N ILEL 75 14.799 15.464 1.142 1.00 8.15 ATOM 672 CA ILE L 75 13.396 15.553 0.932 1.00 9.10 ATOM 673 CB ILEL 75 12.611 15.126 2.187 1.00 11.95 ATOM 674 CG2 ILE L 75 11.132 15.053 1.856 1.00 12.49 ATOM 675 CG1 ILE L 75 13.152 13.789 2.734 1.00 16.99 ATOM 676 CD ILEL 75 12.418 13.281 3.963 1.00 15.52 ATOM 677 C ILE L 75 13.081 17.010 0.632 1.00 12.05 ATOM 678 O ILEL 75 13.212 17.857 1.514 1.00 10.42 ATOM 679 N THRL 76 12.693 17.302 -0.620 1.00 13.27 ATOM 681 CA THRL 76 12.379 18.674 -1.036 1.00 11.86 ATOM 682 CB THR L 76 12.740 18.887 -2.519 1.00 8.49 ATOM 683 OGI THRL 76 14.102 18.539 -2.723 1.00 7.34 WO 99/10379 PCT/GB98/02542 -222 ATOM 685 CG2 THR L 76 12.546 20.321 -2.892 1.00 8.93 ATOM 686 C THR L 76 10.893 18.986 -0.861 1.00 15.75 ATOM 687 O THRL 76 10.044 18.392 -1.538 1.00 19.95 ATOM 688 N GLY L 77 10.567 19.944 0.019 1.00 17.30 ATOM 690 CA GLY L 77 9.167 20.257 0.271 1.00 15.95 ATOM 691 C GLY L 77 8.560 19.175 1.109 1.00 16.40 ATOM 692 O GLY L 77 7.497 18.653 0.784 1.00 17.47 ATOM 693 N ALA L 78 9.237 18.824 2.193 1.00 16.13 ATOM 695 CA ALA L 78 8.765 17.723 3.068 1.00 16.88 ATOM 696 CB ALA L 78 9.674 17.601 4.282 1.00 15.72 ATOM 697 C ALA L 78 7.298 17.890 3.483 1.00 17.09 ATOM 698 O ALAL 78 6.811 18.996 3.691 1.0020.02 ATOM 699 N GLN L 79 6.571 16.773 3.535 1.00 16.23 ATOM 701 CA GLN L 79 5.184 16.787 3.933 1.00 14.31 ATOM 702 CB GLN L 79 4.397 16.061 2.875 1.00 13.55 ATOM 703 CG GLN L 79 4.447 16.805 1.555 1.00 17.28 ATOM 704 CD GLN L 79 3.680 16.127 0.447 1.0022.72 ATOM 705 OEI GLN L 79 3.849 16.479 -0.737 1.00 28.20 ATOM 706 NE2 GLN L 79 2.817 15.163 0.790 1.0022.58 ATOM 709 C GLN L 79 4.972 16.160 5.327 1.00 14.89 ATOM 710 O GLNL 79 5.861 15.498 5.849 1.00 14.38 ATOM 711 N THRL 80 3.796 16.364 5.919 1.00 12.50 ATOM 713 CA THRL 80 3.552 15.895 7.291 1.00 18.91 ATOM 714 CB THRL 80 2.186 16.359 7.810 1.00 17.20 ATOM 715 OGI THRL 80 1.189 15.931 6.884 1.0021.04 ATOM 717 CG2THRL 80 2.139 17.881 7.940 1.00 19.65 ATOM 718 C THRL 80 3.606 14.380 7.362 1.00 19.00 ATOM 719 O THRL 80 4.000 13.812 8.394 1.00 21.72 ATOM 720 N GLU L 81 3.215 13.759 6.252 1.00 18.63 ATOM 722 CA GLUL 81 3.235 12.325 6.104 1.00 19.81 ATOM 723 CB GLUL 81 2.555 11.956 4.801 1.0024.17 ATOM 724 CG GLU L 81 3.338 12.428 3.585 1.00 34.44 ATOM 725 CD GLU L 81 2.657 12.143 2.251 1.0040.56 ATOM 726 OE1 GLU L 81 1.603 12.792 1.960 1.0044.10 ATOM 727 OE2 GLU L 81 3.180 11.280 1.479 1.0043.81 ATOM 728 C GLU L 81 4.660 11.785 6.097 1.00 18.55 ATOM 729 O GLUL 81 4.853 10.588 6.062 1.0020.36 ATOM 730 N ASPL 82 5.665 12.663 6.113 1.00 14.45 ATOM 732 CA ASP L 82 7.027 12.212 6.091 1.00 11.96 ATOM 733 CB ASPL 82 7.902 13.160 5.268 1.00 11.90 ATOM 734 CG ASP L 82 7.523 13.214 3.783 1.00 13.46 ATOM 735 OD1 ASP L 82 6.822 12.310 3.288 1.00 16.83 ATOM 736 OD2ASPL 82 7.906 14.176 3.131 1.00 13.86 ATOM 737 C ASPL 82 7.608 12.087 7.492 1.00 12.84 ATOM 738 O ASPL 82 8.798 11.739 7.639 1.00 9.40 ATOM 739 N GLU L 83 6.844 12.479 8.535 1.00 13.25 ATOM 741 CA GLU L 83 7.360 12.253 9.890 1.00 13.46 ATOM 742 CB GLU L 83 6.371 12.783 10.953 1.00 17.14 ATOM 743 CG GLU L 83 6.849 12.635 12.411 1.0021.93 ATOM 744 CD GLU L 83 6.097 13.555 13.389 1.0026.14 ATOM 745 OE1 GLU L 83 5.812 14.703 13.018 1.00 22.27 ATOM 746 OE2GLUL 83 5.781 13.123 14.531 1.0027.48 ATOM 747 C GLU L 83 7.522 10.729 9.996 1.00 9.35 ATOM 748 O GLU L 83 6.538 10.002 9.819 1.00 12.41 ATOM 749 N ALA L 84 8.733 10.261 10.224 1.00 9.86 ATOM 751 CA ALA L 84 9.002 8.826 10.218 1.00 8.78 WO 99/10379 PCT/GB98/02542 -223 ATOM 752 CB ALA L 84 8.680 8.265 8.839 1.00 7.20 ATOM 753 C ALA L 84 10.451 8.635 10.544 1.00 8.36 ATOM 754 O ALAL 84 11.142 9.614 10.771 1.00 11.79 ATOM 755 N ILE L 85 10.935 7.404 10.597 1.00 8.82 ATOM 757 CA ILE L 85 12.374 7.195 10.869 1.00 7.36 ATOM 758 CB ILE L 85 12.587 6.155 11.972 1.00 5.25 ATOM 759 CG2 ILE L 85 14.073 5.990 12.304 1.00 9.66 ATOM 760 CGI ILEL 85 11.812 6.631 13.206 1.00 13.36 ATOM 761 CD ILE L 85 11.467 5.568 14.201 1.00 10.12 ATOM 762 C ILE L 85 12.996 6.745 9.551 1.00 5.85 ATOM 763 O ILE L 85 12.329 6.082 8.770 1.00 6.76 ATOM 764 N TYRL 86 14.192 7.215 9.275 1.00 4.42 ATOM 766 CA TYRL 86 14.866 6.918 7.986 1.00 7.23 ATOM 767 CB TYRL 86 15.159 8.203 7.200 1.00 6.83 ATOM 768 CG TYRL 86 13.913 8.870 6.716 1.00 8.61 ATOM 769 CD1 TYRL 86 13.172 9.704 7.586 1.00 5.73 ATOM 770 CE1 TYRL 86 11.924 10.187 7.218 1.00 8.65 ATOM 771 CD2 TYRL 86 13.369 8.555 5.449 1.00 5.92 ATOM 772 CE2TYRL 86 12.111 9.039 5.092 1.00 6.08 ATOM 773 CZ TYRL 86 11.391 9.850 5.989 1.00 8.14 ATOM 774 OH TYRL 86 10.104 10.252 5.681 1.00 6.40 ATOM 776 C TYRL 86 16.153 6.242 8.233 1.00 2.00 ATOM 777 O TYRL 86 16.996 6.769 8.949 1.00 8.00 ATOM 778 N PHE L 87 16.301 5.063 7.681 1.00 5.92 ATOM 780 CA PHEL 87 17.557 4.307 7.841 1.00 4.34 ATOM 781 CB PHE L 87 17.251 2.842 8.184 1.00 8.38 ATOM 782 CG PHE L 87 16.602 2.687 9.499 1.00 9.99 ATOM 783 CDI PHEL 87 17.366 2.481 10.618 1.00 6.06 ATOM 784 CD2 PHE L 87 15.220 2.729 9.601 1.00 13.30 ATOM 785 CE1 PHEL 87 16.743 2.308 11.862 1.00 10.61 ATOM 786 CE2 PHE L 87 14.595 2.562 10.826 1.00 14.04 ATOM 787 CZ PHEL 87 15.365 2.348 11.957 1.00 8.48 ATOM 788 C PHEL 87 18.328 4.303 6.562 1.00 3.22 ATOM 789 O PHEL 87 17.707 4.281 5.510 1.00 2.51 ATOM 790 N CYS L 88 19.641 4.310 6.649 1.00 5.93 ATOM 792 CA CYS L 88 20.434 4.144 5.459 1.00 9.35 ATOM 793 CB CYS L 88 21.404 5.297 5.251 1.00 5.49 ATOM 794 SG CYS L 88 22.767 5.371 6.415 1.00 15.50 ATOM 795 C CYS L 88 21.204 2.852 5.597 1.00 8.53 ATOM 796 O CYS L 88 21.483 2.413 6.720 1.00 8.84 ATOM 797 N ALAL 89 21.489 2.213 4.498 1.00 8.42 ATOM 799 CA ALA L 89 22.254 0.975 4.533 1.00 8.94 ATOM 800 CB ALA L 89 21.298 -0.202 4.212 1.00 6.42 ATOM 801 C ALAL 89 23.388 1.099 3.503 1.00 11.22 ATOM 802 O ALA L 89 23.165 1.628 2.418 1.00 10.12 ATOM 803 N LEUL 90 24.596 0.655 3.854 1.00 12.71 ATOM 805 CA LEU L 90 25.735 0.735 2.957 1.00 12.28 ATOM 806 CB LEUL 90 26.855 1.595 3.564 1.00 13.85 ATOM 807 CG LEU L 90 26.569 3.094 3.774 1.00 10.32 ATOM 808 CDI LEU L 90 27.882 3.794 4.141 1.00 7.96 ATOM 809 CD2 LEU L 90 25.941 3.694 2.503 1.00 10.49 ATOM 810 C LEU L 90 26.287 -0.669 2.660 1.00 14.32 ATOM 811 0 LEU L 90 26.362 -1.520 3.582 1.00 14.08 ATOM 812 N TRPL 91 26.696 -0.882 1.373 1.00 10.21 ATOM 814 CA TRPL 91 27.201 -2.184 0.894 1.00 9.56 ATOM 815 CB TRPL 91 26.734 -2.435 -0.548 1.00 13.24 WO 99/10379 PCT/GB98/02542 -224 ATOM 816 CG TRP L 91 27.370 -3.606 -1.295 1.00 16.93 ATOM 817 CD2 TRP L 91 26.974 -5.018 -1.253 1.00 18.28 ATOM 818 CE2 TRP L 91 27.660 -5.679 -2.291 1.00 18.63 ATOM 819 CE3 TRP L 91 26.094 -5.782 -0.455 1.00 18.52 ATOM 820 CDI TRP L 91 28.273 -3.498 -2.320 1.00 18.74 ATOM 821 NEI TRP L 91 28.432 -4.721 -2.902 1.00 18.84 ATOM 823 CZ2 TRP L 91 27.509 -7.069 -2.564 1.00 17.39 ATOM 824 CZ3 TRP L 91 25.935 -7.162 -0.726 1.00 20.45 ATOM 825 CH2 TRP L 91 26.650 -7.793 -1.782 1.00 18.96 ATOM 826 C TRPL 91 28.684 -2.211 0.955 1.00 8.96 ATOM 827 O TRP L 91 29.339 -1.272 0.509 1.00 9.38 ATOM 828 N TYRL 92 29.220 -3.247 1.556 1.00 9.41 ATOM 830 CA TYRL 92 30.649 -3.389 1.630 1.00 10.88 ATOM 831 CB TYRL 92 31.124 -3.365 3.095 1.00 13.13 ATOM 832 CG TYRL 92 30.902 -2.043 3.827 1.00 12.25 ATOM 833 CD1 TYRL 92 29.753 -1.810 4.591 1.00 15.61 ATOM 834 CE1 TYRL 92 29.535 -0.583 5.219 1.00 11.01 ATOM 835 CD2 TYR L 92 31.836 -1.015 3.730 1.00 14.35 ATOM 836 CE2 TYR L 92 31.622 0.197 4.345 1.00 12.95 ATOM 837 CZ TYRL 92 30.472 0.415 5.077 1.00 11.34 ATOM 838 OH TYRL 92 30.237 1.671 5.601 1.00 14.51 ATOM 840 C TYRL 92 31.066 -4.693 0.951 1.00 15.14 ATOM 841 O TYRL 92 31.333 -5.699 1.630 1.00 14.53 ATOM 842 N SERL 93 31.044 -4.664 -0.393 1.00 16.81 ATOM 844 CA SERL 93 31.475 -5.795 -1.251 1.00 18.41 ATOM 845 CB SERL 93 32.907 -6.178 -0.911 1.00 19.53 ATOM 846 OG SERL 93 33.774 -5.132 -1.332 1.00 25.55 ATOM 848 C SERL 93 30.582 -7.038 -1.232 1.0020.20 ATOM 849 O SERL 93 30.266 -7.607 -2.311 1.00 17.43 ATOM 850 N ASN L 94 30.200 -7.482 -0.020 1.00 19.09 ATOM 852 CA ASNL 94 29.417 -8.684 0.119 1.00 19.31 ATOM 853 CB ASN L 94 30.343 -9.906 0.036 1.00 18.06 ATOM 854 CG ASN L 94 31.362 -9.915 1.145 1.0022.80 ATOM 855 ODI ASN L 94 31.381 -9.018 2.021 1.00 22.03 ATOM 856 ND2 ASN L 94 32.219 -10.924 1.140 1.00 21.52 ATOM 859 C ASN L 94 28.618 -8.688 1.425 1.00 20.27 ATOM 860 O ASN L 94 28.207 -9.740 1.908 1.00 22.39 ATOM 861 N HIS L 95 28.396 -7.508 2.003 1.00 19.53 ATOM 863 CA HIS L 95 27.542 -7.405 3.172 1.00 18.65 ATOM 864 CB HIS L 95 28.273 -7.846 4.411 1.00 16.28 ATOM 865 CG HIS L 95 29.434 -6.995 4.785 1.00 19.96 ATOM 866 CD2 HIS L 95 30.655 -6.852 4.227 1.00 17.79 ATOM 867 ND1 HIS L 95 29.472 -6.234 5.944 1.00 20.98 ATOM 869 CEl HIS L 95 30.652 -5.659 6.104 1.00 22.66 ATOM 870 NE2HISL 95 31.371 -6.031 5.064 1.0020.00 ATOM 872 C HIS L 95 27.026 -5.989 3.352 1.00 17.00 ATOM 873 O HIS L 95 27.564 -5.066 2.790 1.00 16.62 ATOM 874 N TRPL 96 25.985 -5.837 4.147 1.00 15.07 ATOM 876 CA TRPL 96 25.383 -4.537 4.360 1.00 13.84 ATOM 877 CB TRP L 96 23.884 -4.547 4.040 1.00 12.09 ATOM 878 CG TRP L 96 23.550 -4.745 2.591 1.00 14.83 ATOM 879 CD2 TRP L 96 23.350 -3.711 1.602 1.00 12.10 ATOM 880 CE2 TRP L 96 22.934 -4.340 0.417 1.00 13.36 ATOM 881 CE3TRPL 96 23.475 -2.311 1.612 1.00 11.19 ATOM 882 CDI TRPL 96 23.265 -5.919 1.979 1.00 15.53 ATOM 883 NEI TRP L 96 22.893 -5.677 0.692 1.00 14.17 WO 99/10379 PCT/GB98/02542 -225 ATOM 885 CZ2 TRP L 96 22.643 -3.626 -0.760 1.00 9.46 ATOM 886 CZ3 TRP L 96 23.181 -1.602 0.451 1.00 7.52 ATOM 887 CH2 TRP L 96 22.774 -2.257 -0.716 1.00 11.56 ATOM 888 C TRP L 96 25.501 -4.165 5.786 1.00 14.61 ATOM 889 O TRP L 96 25.451 -5.057 6.646 1.00 12.87 ATOM 890 N VAL L 97 25.664 -2.859 6.014 1.00 11.97 ATOM 892 CA VAL L 97 25.612 -2.292 7.355 1.00 13.35 ATOM 893 CB VAL L 97 26.971 -1.817 7.809 1.00 12.63 ATOM 894 CGI VAL L 97 26.881 -1.178 9.180 1.00 14.09 ATOM 895 CG2 VAL L 97 27.865 -3.039 7.849 1.00 8.66 ATOM 896 C VAL L 97 24.600 -1.158 7.382 1.00 14.93 ATOM 897 0 VALL 97 24.581 -0.311 6.477 1.00 9.72 ATOM 898 N PHEL 98 23.666 -1.233 8.342 1.00 13.01 ATOM 900 CA PHEL 98 22.629 -0.239 8.458 1.00 12.29 ATOM 901 CB PHEL 98 21.317 -0.875 8.885 1.00 9.91 ATOM 902 CG PHEL 98 20.505 -1.489 7.798 1.00 7.44 ATOM 903 CD1 PHEL 98 20.799 -2.748 7.325 1.00 9.14 ATOM 904 CD2 PHE L 98 19.392 -0.848 7.326 1.00 6.37 ATOM 905 CE1 PHEL 98 19.985 -3.342 6.410 1.00 6.90 ATOM 906 CE2 PHE L 98 18.557 -1.432 6.398 1.00 8.01 ATOM 907 CZ PHEL 98 18.849 -2.688 5.932 1.00 7.78 ATOM 908 C PHEL 98 23.034 0.838 9.452 1.00 11.91 ATOM 909 O PHEL 98 23.871 0.596 10.313 1.00 11.43 ATOM 910 N GLYL 99 22.517 2.053 9.239 1.00 14.08 ATOM 912 CA GLY L 99 22.775 3.153 10.134 1.00 12.11 ATOM 913 C GLYL 99 21.797 3.085 11.289 1.00 11.79 ATOM 914 O GLY L 99 20.892 2.267 11.267 1.00 10.46 ATOM 915 N GLY L 100 21.971 3.955 12.280 1.00 12.00 ATOM 917 CA GLYL 100 21.103 3.943 13.451 1.00 8.79 ATOM 918 C GLY L 100 19.723 4.507 13.256 1.00 9.23 ATOM 919 O GLYL 100 18.832 4.282 14.101 1.00 12.86 ATOM 920 N GLY L 101 19.494 5.204 12.159 1.00 7.60 ATOM 922 CA GLYL 101 18.172 5.776 11.925 1.00 4.00 ATOM 923 C GLYL 101 18.149 7.204 12.428 1.00 7.52 ATOM 924 O GLY L 101 18.914 7.549 13.399 1.00 7.76 ATOM 925 N THRL 102 17.410 8.046 11.676 1.00 8.12 ATOM 927 CA THRL 102 17.197 9.482 11.996 1.00 7.96 ATOM 928 CB THRL 102 17.621 10.421 10.792 1.00 7.52 ATOM 929 OGI THRL 102 19.018 10.307 10.564 1.00 4.45 ATOM 931 CG2THRL 102 17.291 11.883 11.056 1.00 4.44 ATOM 932 C THRL 102 15.717 9.657 12.207 1.00 10.01 ATOM 933 O THRL 102 14.961 9.267 11.332 1.00 11.13 ATOM 934 N LYSL 103 15.248 10.189 13.349 1.00 10.41 ATOM 936 CA LYS L 103 13.807 10.407 13.447 1.00 11.36 ATOM 937 CB LYS L 103 13.261 10.443 14.902 1.00 14.52 ATOM 938 CG LYS L 103 11.801 10.989 14.933 1.00 16.54 ATOM 939 CD LYSL 103 11.212 11.110 16.350 1.00 12.70 ATOM 940 CE LYS L 103 9.750 11.551 16.305 1.00 14.64 ATOM 941 NZ LYSL 103 8.858 10.636 15.481 1.00 17.17 ATOM 945 C LYSL 103 13.468 11.724 12.798 1.00 10.60 ATOM 946 O LYSL 103 14.030 12.728 13.180 1.00 12.19 ATOM 947 N LEUL 104 12.546 11.725 11.853 1.00 9.69 ATOM 949 CA LEU L 104 12.183 12.968 11.229 1.00 11.35 ATOM 950 CB LEUL 104 12.125 12.864 9.693 1.00 9.61 ATOM 951 CG LEUL 104 11.724 14.187 9.012 1.00 10.81 ATOM 952 CDI LEUL 104 12.847 15.212 9.199 1.00 2.00 WO 99/10379 PCT/GB98/02542 -226 ATOM 953 CD2 LEU L 104 11.408 13.947 7.560 1.00 10.86 ATOM 954 C LEU L 104 10.866 13.484 11.728 1.00 10.04 ATOM 955 0 LEU L 104 9.862 12.794 11.656 1.00 16.01 ATOM 956 N THRL 105 10.861 14.711 12.251 1.00 11.71 ATOM 958 CA THRL 105 9.614 15.361 12.576 1.00 7.07 ATOM 959 CB THRL 105 9.682 16.091 13.949 1.00 9.46 ATOM 960 OGI THR L 105 9.844 15.129 14.983 1.00 12.27 ATOM 962 CG2THRL 105 8.415 16.918 14.200 1.00 2.15 ATOM 963 C THR L 105 9.271 16.410 11.513 1.00 7.56 ATOM 964 O THR L 105 10.093 17.241 11.182 1.00 9.71 ATOM 965 N VAL L 106 8.084 16.320 10.974 1.00 9.73 ATOM 967 CA VALL 106 7.541 17.364 10.106 1.00 11.58 ATOM 968 CB VAL L 106 7.106 16.851 8.725 1.00 9.06 ATOM 969 CGI VALL 106 6.526 18.000 7.911 1.00 6.52 ATOM 970 CG2 VAL L 106 8.329 16.228 8.011 1.00 10.40 ATOM 971 C VALL 106 6.335 17.931 10.856 1.00 11.09 ATOM 972 0 VALL 106 5.242 17.324 10.877 1.00 13.54 ATOM 973 N LEUL 106A 6.601 19.071 11.521 1.00 12.43 ATOM 975 CA LEU L 106A 5.655 19.710 12.378 1.00 12.13 ATOM 976 CB LEU L 106A 6.116 21.132 12.666 1.00 9.12 ATOM 977 CG LEU L 106A 7.488 21.225 13.349 1.00 7.72 ATOM 978 CD1 LEU L 106A 7.990 22.640 13.270 1.00 9.05 ATOM 979 CD2 LEU L 106A 7.413 20.730 14.816 1.00 6.98 ATOM 980 C LEU L 106A 4.325 19.678 11.752 1.00 13.07 ATOM 981 O LEU L 106A 4.094 20.360 10.779 1.00 18.75 ATOM 982 N GLYL 107 3.468 18.816 12.284 1.00 14.91 ATOM 984 CA GLYL 107 2.117 18.689 11.760 1.00 16.40 ATOM 985 C GLYL 107 1.065 19.137 12.762 1.00 15.29 ATOM 986 O GLYL 107 -0.112 18.925 12.547 1.00 16.64 ATOM 987 N SERL 108 1.523 19.742 13.859 1.00 18.60 ATOM 989 CA SERL 108 0.647 20.251 14.907 1.00 18.91 ATOM 990 CB SERL 108 0.095 19.123 15.790 1.00 21.02 ATOM 991 OG SERL 108 1.115 18.543 16.596 1.0027.15 ATOM 993 C SERL 108 1.453 21.165 15.760 1.00 17.58 ATOM 994 O SER L 108 2.676 21.208 15.641 1.00 17.99 ATOM 995 N GLU L 109 0.776 21.825 16.671 1.00 17.83 ATOM 997 CA GLU L 109 1.409 22.775 17.516 1.00 16.58 ATOM 998 CB GLU L 109 0.305 23.562 18.224 1.00 21.42 ATOM 999 CG GLU L 109 -0.525 24.468 17.320 1.00 26.54 ATOM 1000 CD GLUL 109 -1.319 23.742 16.234 0.50 27.76 ATOM 1001 OE1 GLU L 109 -1.764 22.614 16.502 0.50 28.73 ATOM 1002 OE2 GLU L 109 -1.502 24.309 15.104 0.50 26.82 ATOM 1003 C GLU L 109 2.287 22.041 18.513 1.00 17.20 ATOM 1004 O GLU L 109 1.915 20.964 18.956 1.00 14.41 ATOM 1005 N LYSL 110 3.430 22.599 18.883 1.00 16.72 ATOM 1007 CA LYS L 110 4.266 21.914 19.845 1.0020.99 ATOM 1008 CB LYSL 110 5.618 22.584 19.993 1.0022.20 ATOM 1009 CG LYS L 110 6.477 22.377 18.759 1.0024.75 ATOM 1010 CD LYS L 110 7.786 23.126 18.835 1.0025.15 ATOM 1011 CE LYS L 110 8.531 23.023 17.513 1.0030.78 ATOM 1012 NZ LYS L 110 9.941 23.516 17.611 1.0032.12 ATOM 1016 C LYSLII 0 3.566 21.804 21.187 1.0021.68 ATOM 1017 O LYSL 110 2.769 22.673 21.557 1.0022.35 ATOM 1018 N SERLlll 3.834 20.699 21.876 1.0022.71 ATOM 1020 CA SERL 11 3.196 20.395 23.158 1.0021.05 ATOM 1021 CB SERLI 111 2.113 19.354 22.921 1.0022.18 WO 99/10379 PCT/GB98/02542 -227 ATOM 1022 OG SERL Ill 1.309 19.148 24.070 1.00 23.73 ATOM 1024 C SERLIll 4.253 19.859 24.139 1.0021.55 ATOM 1025 O SERLlll 5.049 18.979 23.790 1.0021.72 ATOM 1026 N SERL 112 4.318 20.457 25.339 1.00 19.80 ATOM 1028 CA SERL 112 5.272 20.047 26.347 1.00 17.43 ATOM 1029 CB SERL 112 5.370 21.141 27.399 1.00 20.85 ATOM 1030 OG SERL 112 6.322 22.114 27.001 1.0029.98 ATOM 1032 C SERL 112 4.864 18.727 26.995 1.00 14.25 ATOM 1033 O SERL 112 3.669 18.409 27.067 1.00 19.12 ATOM 1034 N PRO L 113 5.812 17.929 27.481 1.00 10.92 ATOM 1035 CD PRO L 113 7.264 18.153 27.529 1.00 7.81 ATOM 1036 CA PRO L 113 5.463 16.677 28.106 1.00 12.79 ATOM 1037 CB PROL 113 6.784 15.979 28.215 1.00 8.93 ATOM 1038 CG PRO L 113 7.704 17.092 28.478 1.00 9.20 ATOM 1039 C PROL 113 4.802 16.881 29.473 1.00 13.59 ATOM 1040 O PROL 113 5.173 17.782 30.241 1.00 13.35 ATOM 1041 N SERL 114 3.781 16.101 29.736 1.00 15.55 ATOM 1043 CA SERL 114 3.219 16.052 31.062 1.00 15.08 ATOM 1044 CB SERL 114 1.722 15.844 31.000 1.00 17.33 ATOM 1045 OG SER L 114 1.154 15.908 32.312 1.0025.09 ATOM 1047 C SERL 114 3.903 14.913 31.831 1.00 16.29 ATOM 1048 O SERL 114 3.804 13.718 31.467 1.00 15.53 ATOM 1049 N VALL 115 4.617 15.295 32.871 1.00 12.98 ATOM 1051 CA VALL 115 5.426 14.370 33.674 1.00 12.33 ATOM 1052 CB VALL 115 6.752 15.009 33.988 1.00 6.39 ATOM 1053 CG1 VAL L 115 7.709 13.979 34.583 1.00 3.44 ATOM 1054 CG2 VAL L 115 7.306 15.645 32.716 1.00 9.96 ATOM 1055 C VALL 115 4.779 13.996 35.004 1.00 13.58 ATOM 1056 0 VALL 115 4.226 14.837 35.693 1.00 13.43 ATOM 1057 N THRL 116 4.880 12.748 35.361 1.00 12.99 ATOM 1059 CA THR L 116 4.398 12.295 36.649 1.00 11.92 ATOM 1060 CB THRL 116 3.062 11.557 36.565 1.00 10.15 ATOM 1061 OGI THRL 116 2.138 12.351 35.833 1.00 5.53 ATOM 1063 CG2THRL 116 2.519 11.284 37.978 1.00 10.07 ATOM 1064 C THRL 116 5.419 11.336 37.207 1.00 13.44 ATOM 1065 O THRL 116 5.864 10.407 36.480 1.00 13.00 ATOM 1066 N LEU L 117 5.820 11.574 38.463 1.00 9.86 ATOM 1068 CA LEUL 117 6.777 10.703 39.114 1.00 10.48 ATOM 1069 CB LEUL 117 7.978 11.514 39.513 1.00 8.99 ATOM 1070 CG LEU L 117 9.092 10.738 40.197 1.00 13.84 ATOM 1071 CDI LEU L 117 9.766 9.779 39.216 1.00 10.30 ATOM 1072 CD2 LEU L 117 10.091 11.720 40.799 1.00 17.17 ATOM 1073 C LEUL 117 6.142 9.970 40.330 1.00 9.98 ATOM 1074 O LEUL 117 5.456 10.564 41.158 1.00 12.16 ATOM 1075 N PHEL 118 6.332 8.676 40.390 1.00 9.99 ATOM 1077 CA PHEL 118 5.750 7.864 41.440 1.00 9.51 ATOM 1078 CB PHEL 118 4.876 6.751 40.867 1.00 6.53 ATOM 1079 CG PHEL 118 3.652 7.208 40.172 1.00 6.03 ATOM 1080 CDI PHEL 118 2.538 7.603 40.901 1.00 4.85 ATOM 1081 CD2PHEL 118 3.569 7.161 38.762 1.00 3.25 ATOM 1082 CEI PHEL 118 1.345 7.933 40.264 1.00 6.00 ATOM 1083 CE2PHEL 118 2.385 7.501 38.128 1.00 2.00 ATOM 1084 CZ PHEL 118 1.263 7.883 38.881 1.00 3.81 ATOM 1085 C PHEL 118 6.835 7.216 42.272 1.00 9.33 ATOM 1086 O PHEL 118 7.864 6.711 41.759 1.00 9.88 ATOM 1087 N PRO L 119 6.623 7.228 43.586 1.00 9.00 WO 99/10379 PCT/GB98/02542 -228 ATOM 1088 CD PRO L 119 5.434 7.839 44.252 1.00 7.59 ATOM 1089 CA PRO L 19 7.553 6.629 44.549 1.00 8.55 ATOM 1090 CB PROL 119 7.113 7.293 45.852 1.00 9.62 ATOM 1091 CG PRO L 119 5.627 7.381 45.676 1.00 9.04 ATOM 1092 C PRO L 119 7.347 5.128 44.604 1.00 4.72 ATOM 1093 O PRO L 119 6.358 4.656 44.103 1.00 6.50 ATOM 1094 N PRO L 120 8.278 4.373 45.160 1.00 3.79 ATOM 1095 CD PRO L 120 9.622 4.803 45.475 1.00 6.28 ATOM 1096 CA PRO L 120 8.131 2.923 45.298 1.00 6.76 ATOM 1097 CB PRO L 120 9.489 2.431 45.730 1.00 9.39 ATOM 1098 CG PRO L 120 10.182 3.627 46.233 1.00 5.45 ATOM 1099 C PRO L 120 7.022 2.552 46.275 1.00 10.87 ATOM 1100 O PRO L 120 6.768 3.266 47.252 1.00 11.35 ATOM 1101 N SERL 121 6.290 1.505 45.965 1.00 12.02 ATOM 1103 CA SERL 121 5.183 1.088 46.829 1.00 14.15 ATOM 1104 CB SERL 121 4.178 0.155 46.082 1.00 13.52 ATOM 1105 OG SERL 121 4.763 -1.084 45.722 1.00 14.31 ATOM 1107 C SERL 121 5.748 0.403 48.072 1.00 15.89 ATOM 1108 O SERL 121 6.927 -0.008 48.091 1.00 14.68 ATOM 1109 N SERL 122 4.932 0.332 49.125 1.00 15.71 ATOM 1111 CA SERL 122 5.367 -0.320 50.342 1.00 17.27 ATOM 1112 CB SERL 122 4.344 -0.069 51.454 1.00 17.69 ATOM 1113 OG SERL 122 3.021 -0.319 50.990 1.00 25.59 ATOM 1115 C SERL 122 5.508 -1.809 50.072 1.00 14.07 ATOM 1116 O SERL 122 6.469 -2.436 50.541 1.00 16.14 ATOM 1117 N ALA L 123 4.563 -2.344 49.269 1.00 11.63 ATOM 1119 CA ALA L 123 4.568 -3.775 48.940 1.00 10.10 ATOM 1120 CB ALA L 123 3.326 -4.126 48.147 1.00 13.01 ATOM 1121 C ALAL 123 5.839 -4.151 48.206 1.00 9.75 ATOM 1122 O ALA L 123 6.494 -5.134 48.561 1.00 6.87 ATOM 1123 N GLU L 124 6.260 -3.325 47.226 1.00 8.37 ATOM 1125 CA GLU L 124 7.492 -3.604 46.547 1.00 7.57 ATOM 1126 CB GLUL 124 7.788 -2.653 45.376 1.00 9.85 ATOM 1127 CG GLU L 124 9.105 -3.016 44.693 1.00 9.19 ATOM 1128 CD GLU L 124 9.483 -2.129 43.532 1.00 8.89 ATOM 1129 OEI GLU L 124 8.883 -1.080 43.391 1.00 11.65 ATOM 1130 OE2 GLU L 124 10.390 -2.478 42.764 1.00 10.96 ATOM 1131 C GLUL 124 8.648 -3.537 47.490 1.00 8.44 ATOM 1132 O GLUL 124 9.501 -4.428 47.481 1.00 7.83 ATOM 1133 N LEUL 125 8.687 -2.489 48.336 1.00 10.06 ATOM 1135 CA LEU L 125 9.820 -2.290 49.278 1.00 8.99 ATOM 1136 CB LEUL 125 9.562 -1.051 50.156 1.00 6.82 ATOM 1137 CG LEUL 125 9.870 0.278 49.456 1.00 8.44 ATOM 1138 CD1LEUL 125 9.233 1.465 50.157 1.00 10.23 ATOM 1139 CD2 LEU L 125 11.372 0.457 49.354 1.00 10.82 ATOM 1140 C LEUL 125 10.101 -3.500 50.160 1.00 7.68 ATOM 1141 O LEUL 125 11.267 -3.786 50.516 1.00 6.19 ATOM 1142 N GLUL 126 9.055 -4.208 50.514 1.00 9.15 ATOM 1144 CA GLUL 126 9.226 -5.389 51.339 1.00 12.67 ATOM 1145 CB GLU L 126 7.906 -6.055 51.525 1.00 15.98 ATOM 1146 CG GLU L 126 6.902 -5.183 52.204 1.00 19.89 ATOM 1147 CD GLU L 126 5.648 -5.941 52.477 1.00 22.91 ATOM 1148 OE1 GLU L 126 5.674 -7.203 52.445 1.00 24.59 ATOM 1149 OE2 GLU L 126 4.627 -5.286 52.726 1.00 26.87 ATOM 1150 C GLUL 126 10.169 -6.381 50.692 1.00 14.63 ATOM 1151 O GLUL 126 10.849 -7.147 51.409 1.00 12.25 WO 99/10379 PCT/GB98/02542 -229 ATOM 1152 N THRL 127 10.177 -6.394 49.316 1.00 13.98 ATOM 1154 CA THR L 127 11.063 -7.308 48.538 1.00 13.13 ATOM 1155 CB THRL 127 10.565 -7.557 47.071 1.00 11.80 ATOM 1156 OGI THRL 127 10.749 -6.384 46.266 1.00 10.21 ATOM 1158 CG2THRL 127 9.095 -7.940 47.045 1.00 12.12 ATOM 1159 C THRL 127 12.468 -6.773 48.455 1.00 12.72 ATOM 1160 O THRL 127 13.278 -7.319 47.728 1.00 14.85 ATOM 1161 N ASN L 128 12.744 -5.701 49.209 1.00 13.49 ATOM 1163 CA ASN L 128 14.053 -5.049 49.228 1.00 13.82 ATOM 1164 CB ASN L 128 15.159 -6.035 49.674 1.00 19.63 ATOM 1165 CG ASN L 128 15.148 -6.262 51.183 1.0023.79 ATOM 1166 ODI ASN L 128 14.978 -7.388 51.646 1.00 26.72 ATOM 1167 ND2ASNL 128 15.329 -5.186 51.962 1.0025.77 ATOM 1170 C ASN L 128 14.414 -4.367 47.901 1.00 14.19 ATOM 1171 O ASNL 128 15.611 -4.119 47.595 1.00 13.24 ATOM 1172 N LYSL 129 13.375 -4.018 47.146 1.00 17.87 ATOM 1174 CA LYS L 129 13.534 -3.327 45.875 1.00 18.00 ATOM 1175 CB LYS L 129 13.092 -4.229 44.705 1.00 22.35 ATOM 1176 CG LYS L 129 13.737 -5.609 44.662 1.00 24.95 ATOM 1177 CD LYS L 129 15.231 -5.502 44.540 1.0028.22 ATOM 1178 CE LYS L 129 15.855 -6.861 44.340 1.00 30.22 ATOM 1179 NZ LYS L 129 15.417 -7.440 43.042 1.00 34.30 ATOM 1183 C LYS L 129 12.686 -2.050 45.854 1.00 16.78 ATOM 1184 O LYSL 129 11.623 -1.980 46.448 1.00 15.40 ATOM 1185 N ALAL 130 13.173 -1.048 45.154 1.00 16.40 ATOM 1187 CA ALA L 130 12.448 0.214 44.999 1.00 15.30 ATOM 1188 CB ALAL 130 12.977 1.267 45.964 1.00 10.48 ATOM 1189 C ALA L 130 12.572 0.727 43.545 1.00 13.30 ATOM 1190 O ALA L 130 13.691 0.988 43.056 1.00 13.88 ATOM 1191 N THRL 131 11.412 0.808 42.863 1.00 10.24 ATOM 1193 CA THRL 131 11.349 1.323 41.522 1.00 8.65 ATOM 1194 CB THRL 131 10.665 0.346 40.546 1.00 9.65 ATOM 1195 OGI THRL 131 11.277 -0.964 40.640 1.00 10.61 ATOM 1197 CG2THRL 131 10.733 0.897 39.099 1.00 8.13 ATOM 1198 C THRL 131 10.550 2.594 41.507 1.00 4.73 ATOM 1199 O THRL 131 9.443 2.621 42.017 1.00 7.42 ATOM 1200 N LEUL 132 11.136 3.637 40.962 1.00 5.79 ATOM 1202 CA LEU L 132 10.436 4.899 40.780 1.00 8.20 ATOM 1203 CB LEUL 132 11.372 6.085 41.065 1.00 7.00 ATOM 1204 CG LEU L 132 11.780 6.385 42.529 1.00 9.11 ATOM 1205 CDI LEU L 132 12.638 5.274 43.087 1.00 6.00 ATOM 1206 CD2 LEU L 132 12.583 7.694 42.582 1.00 8.20 ATOM 1207 C LEU L 132 9.971 4.967 39.336 1.00 7.07 ATOM 1208 O LEU L 132 10.752 4.681 38.446 1.00 10.93 ATOM 1209 N VAL L 133 8.735 5.309 39.105 1.00 7.44 ATOM 1211 CA VALL 133 8.228 5.345 37.740 1.00 7.69 ATOM 1212 CB VALL 133 6.906 4.586 37.603 1.00 5.71 ATOM 1213 CGI VAL L 133 6.388 4.659 36.159 1.00 5.28 ATOM 1214 CG2 VALL 133 7.115 3.122 38.014 1.00 10.59 ATOM 1215 C VALL 133 7.979 6.767 37.291 1.00 8.68 ATOM 1216 0 VALL 133 7.319 7.530 37.961 1.00 8.54 ATOM 1217 N CYS L 134 8.460 7.109 36.130 1.00 12.17 ATOM 1219 CA CYS L 134 8.218 8.450 35.589 1.00 9.67 ATOM 1220 CB CYSL 134 9.569 9.119 35.343 1.00 8.40 ATOM 1221 SG CYSL 134 9.446 10.804 34.667 1.00 10.83 ATOM 1222 C CYS L 134 7.465 8.302 34.290 1.00 9.67 WO 99/10379 PCT/GB98/02542 -230 ATOM 1223 O CYS L 134 8.017 7.705 33.364 1.00 10.89 ATOM 1224 N THRL 135 6.209 8.737 34.238 1.00 6.29 ATOM 1226 CA THRL 135 5.480 8.651 33.029 1.00 5.35 ATOM 1227 CB THRL 135 4.031 8.177 33.248 1.00 5.71 ATOM 1228 OGI THRL 135 3.243 9.196 33.888 1.00 11.96 ATOM 1230 CG2 THRL 135 4.020 6.904 34.103 1.00 2.00 ATOM 1231 C THRL 135 5.549 9.988 32.324 1.00 9.71 ATOM 1232 O THRL 135 5.820 11.015 32.958 1.00 11.41 ATOM 1233 N ILEL 136 5.440 9.989 31.002 1.00 9.98 ATOM 1235 CA ILE L 136 5.696 11.237 30.220 1.00 11.09 ATOM 1236 CB ILE L 136 7.171 11.270 29.677 1.00 12.20 ATOM 1237 CG2 ILE L 136 7.447 12.606 28.973 1.00 10.90 ATOM 1238 CG1 ILEL 136 8.185 11.008 30.796 1.00 10.97 ATOM 1239 CD ILEL 136 9.585 10.663 30.291 1.00 11.49 ATOM 1240 C ILEL 136 4.750 11.230 29.030 1.00 10.64 ATOM 1241 O ILEL 136 4.856 10.351 28.213 1.00 11.08 ATOM 1242 N THRL 137 3.811 12.165 28.941 1.00 10.77 ATOM 1244 CA THRL 137 2.822 12.072 27.911 1.00 9.97 ATOM 1245 CB THRL 137 1.480 11.508 28.492 1.00 11.90 ATOM 1246 OGI THRL 137 0.871 12.407 29.467 1.00 11.66 ATOM 1248 CG2 THR L 137 1.739 10.177 29.180 1.00 12.72 ATOM 1249 C THRL 137 2.603 13.412 27.228 1.00 13.30 ATOM 1250 O THRL 137 3.179 14.432 27.673 1.00 10.45 ATOM 1251 N ASP L 138 1.843 13.350 26.118 1.00 12.35 ATOM 1253 CA ASP L 138 1.351 14.531 25.355 1.00 14.23 ATOM 1254 CB ASP L 138 0.323 15.306 26.176 1.00 12.77 ATOM 1255 CG ASP L 138 -0.780 14.436 26.702 1.00 16.64 ATOM 1256 ODI ASPL 138 -1.708 14.078 25.914 1.00 15.94 ATOM 1257 OD2 ASP L 138 -0.734 14.100 27.912 1.00 16.10 ATOM 1258 C ASPL 138 2.413 15.502 24.881 1.00 12.96 ATOM 1259 O ASPL 138 2.186 16.705 24.905 1.00 13.42 ATOM 1260 N PHEL 139 3.568 15.011 24.444 1.00 15.33 ATOM 1262 CA PHEL 139 4.597 15.917 23.904 1.00 12.61 ATOM 1263 CB PHEL 139 5.991 15.682 24.506 1.00 13.93 ATOM 1264 CG PHE L 139 6.464 14.248 24.548 1.00 17.51 ATOM 1265 CDI PHE L 139 6.004 13.382 25.535 1.00 14.06 ATOM 1266 CD2 PHE L 139 7.387 13.775 23.609 1.00 18.44 ATOM 1267 CEl PHE L 139 6.444 12.088 25.589 1.00 15.91 ATOM 1268 CE2 PHE L 139 7.829 12.467 23.665 1.00 17.97 ATOM 1269 CZ PHEL 139 7.354 11.618 24.659 1.00 19.08 ATOM 1270 C PHE L 139 4.685 15.810 22.403 1.00 14.58 ATOM 1271 O PHEL 139 4.391 14.757 21.835 1.00 13.97 ATOM 1272 N TYRL 140 5.010 16.951 21.763 1.00 14.53 ATOM 1274 CA TYRL 140 5.219 17.022 20.306 1.00 15.96 ATOM 1275 CB TYRL 140 3.929 17.256 19.548 1.00 9.65 ATOM 1276 CG TYRL 140 4.150 17.200 18.050 1.00 17.09 ATOM 1277 CDI TYRL 140 4.110 15.993 17.372 1.00 18.26 ATOM 1278 CE1 TYR L 140 4.355 15.923 16.003 1.00 18.78 ATOM 1279 CD2 TYR L 140 4.443 18.351 17.312 1.00 17.33 ATOM 1280 CE2 TYR L 140 4.691 18.289 15.945 1.00 17.98 ATOM 1281 CZ TYRL 140 4.639 17.069 15.307 1.00 19.92 ATOM 1282 OH TYRL 140 4.842 16.999 13.958 1.0021.97 ATOM 1284 C TYRL 140 6.148 18.174 20.045 1.00 14.90 ATOM 1285 O TYRL 140 5.815 19.264 20.460 1.00 17.79 ATOM 1286 N PRO L 141 7.336 18.004 19.364 1.00 17.44 ATOM 1287 CD PRO L 141 8.342 19.079 19.203 1.00 18.49 WO 99/10379 PCT/GB98/02542 -231 ATOM 1288 CA PRO L 141 7.877 16.736 18.791 1.00 16.51 ATOM 1289 CB PRO L 141 9.278 17.128 18.347 1.00 16.41 ATOM 1290 CG PRO L 141 9.148 18.569 18.067 1.00 18.35 ATOM 1291 C PRO L 141 7.979 15.574 19.770 1.00 17.49 ATOM 1292 O PROL 141 8.111 15.777 20.988 1.0016.25 ATOM 1293 N GLY L 142 7.960 14.373 19.221 1.00 16.47 ATOM 1295 CA GLY L 142 8.127 13.182 20.027 1.00 17.96 ATOM 1296 C GLY L 142 9.568 12.873 20.379 1.00 17.11 ATOM 1297 O GLY L 142 10.011 11.740 20.287 1.0020.37 ATOM 1298 N VAL L 143 10.332 13.846 20.753 1.00 17.91 ATOM 1300 CA VAL L 143 11.674 13.548 21.201 1.00 20.37 ATOM 1301 CB VAL L 143 12.750 13.989 20.189 1.00 25.23 ATOM 1302 CG1 VAL L 143 12.526 15.434 19.776 1.00 27.03 ATOM 1303 CG2VALL 143 14.139 13.811 20.807 1.00 23.81 ATOM 1304 C VAL L 143 11.937 14.194 22.555 1.0020.36 ATOM 1305 0 VALL 143 11.696 15.394 22.719 1.00 18.56 ATOM 1306 N VAL L 144 12.421 13.375 23.518 1.00 18.00 ATOM 1308 CA VAL L 144 12.729 13.837 24.885 1.00 18.09 ATOM 1309 CB VAL L 144 11.586 13.520 25.905 1.00 15.31 ATOM 1310 CGI VAL L 144 10.361 14.336 25.624 1.00 13.05 ATOM 1311 CG2VALL 144 11.246 12.034 25.879 1.00 15.08 ATOM 1312 C VAL L 144 13.952 13.124 25.398 1.00 17.23 ATOM 1313 0 VALL 144 14.204 11.987 24.997 1.00 15.86 ATOM 1314 N THRL 145 14.747 13.803 26.217 1.00 16.98 ATOM 1316 CA THRL 145 15.794 13.116 26.930 1.00 17.36 ATOM 1317 CB THRL 145 17.242 13.734 26.774 1.00 22.21 ATOM 1318 OG1 THRL 145 17.616 14.518 27.914 1.0022.36 ATOM 1320 CG2THRL 145 17.364 14.570 25.512 1.00 19.06 ATOM 1321 C THRL 145 15.373 13.105 28.394 1.00 19.55 ATOM 1322 O THR L 145 14.797 14.085 28.864 1.00 15.45 ATOM 1323 N VALL 146 15.581 11.966 29.070 1.00 19.67 ATOM 1325 CA VAL L 146 15.178 11.799 30.468 1.00 17.75 ATOM 1326 CB VALL 146 14.336 10.511 30.665 1.00 15.39 ATOM 1327 CGI VAL L 146 14.047 10.262 32.148 1.00 16.28 ATOM 1328 CG2 VAL L 146 13.047 10.641 29.918 1.00 12.45 ATOM 1329 C VALL 146 16.425 11.702 31.322 1.00 18.57 ATOM 1330 0 VAL L 146 17.336 10.964 30.998 1.00 20.82 ATOM 1331 N ASP L 147 16.464 12.470 32.388 1.00 16.64 ATOM 1333 CA ASP L 147 17.595 12.483 33.267 1.00 16.87 ATOM 1334 CB ASPL 147 18.330 13.834 33.113 1.0022.38 ATOM 1335 CG ASPL 147 19.078 13.955 31.783 1.0025.15 ATOM 1336 ODI ASPL 147 20.155 13.339 31.665 1.00 25.53 ATOM 1337 OD2 ASP L 147 18.579 14.656 30.862 1.00 24.06 ATOM 1338 C ASPL 147 17.111 12.297 34.702 1.00 13.63 ATOM 1339 O ASP L 147 16.206 13.007 35.146 1.00 17.40 ATOM 1340 N TRPL 148 17.692 11.353 35.403 1.00 12.32 ATOM 1342 CA TRP L 148 17.296 11.059 36.799 1.00 8.34 ATOM 1343 CB TRPL 148 17.205 9.517 37.013 1.00 7.75 ATOM 1344 CG TRPL 148 16.011 8.871 36.393 1.00 9.41 ATOM 1345 CD2TRPL 148 14.735 8.685 37.020 1.00 7.75 ATOM 1346 CE2 TRP L 148 13.897 8.085 36.079 1.00 9.98 ATOM 1347 CE3TRPL 148 14.234 8.974 38.312 1.00 11.38 ATOM 1348 CDI TRP L 148 15.894 8.383 35.122 1.00 5.30 ATOM 1349 NEI TRP L 148 14.636 7.923 34.955 1.00 10.25 ATOM 1351 CZ2 TRP L 148 12.570 7.753 36.354 1.00 10.62 ATOM 1352 CZ3 TRPL 148 12.921 8.645 38.604 1.00 8.84 WO 99/10379 PCT/GB98/02542 -232 ATOM 1353 CH2 TRP L 148 12.095 8.040 37.623 1.00 9.81 ATOM 1354 C TRP L 148 18.339 11.610 37.747 1.00 10.55 ATOM 1355 O TRP L 148 19.536 11.570 37.449 1.00 11.66 ATOM 1356 N LYS L 149 17.912 12.107 38.895 1.00 10.12 ATOM 1358 CA LYS L 149 18.860 12.586 39.861 1.00 10.24 ATOM 1359 CB LYS L 149 18.984 14.117 39.736 1.00 9.85 ATOM 1360 CG LYS L 149 19.865 14.477 38.528 1.00 15.84 ATOM 1361 CD LYS L 149 19.782 15.929 38.126 1.0020.45 ATOM 1362 CE LYS L 149 20.998 16.333 37.272 1.0025.03 ATOM 1363 NZ LYS L 149 21.311 15.344 36.170 1.0026.83 ATOM 1367 C LYS L 149 18.493 12.114 41.261 1.00 9.83 ATOM 1368 O LYS L 149 17.327 11.939 41.568 1.00 8.42 ATOM 1369 N VAL L 150 19.529 11.821 42.045 1.00 12.70 ATOM 1371 CA VALL 150 19.363 11.400 43.445 1.00 13.13 ATOM 1372 CB VAL L 150 19.874 9.958 43.597 1.00 14.08 ATOM 1373 CG1 VALL 150 20.311 9.690 45.000 1.00 9.65 ATOM 1374 CG2 VAL L 150 18.760 8.990 43.198 1.00 12.12 ATOM 1375 C VAL L 150 20.137 12.357 44.381 1.00 13.82 ATOM 1376 OVAL L 150 21.379 12.391 44.371 1.00 11.33 ATOM 1377 N ASP L 151 19.393 13.156 45.184 1.00 15.72 ATOM 1379 CA ASPL 151 20.020 14.166 46.056 1.00 13.64 ATOM 1380 CB ASP L 151 20.884 13.516 47.141 1.00 17.87 ATOM 1381 CG ASP L 151 20.085 12.908 48.292 1.00 18.72 ATOM 1382 ODI ASPL 151 18.851 13.014 48.304 1.00 17.99 ATOM 1383 OD2ASPL 151 20.701 12.320 49.195 1.00 20.12 ATOM 1384 C ASPL 151 20.841 15.107 45.202 1.00 12.12 ATOM 1385 O ASPL 151 21.967 15.546 45.535 1.00 14.72 ATOM 1386 N GLY L 152 20.285 15.373 44.070 1.00 13.53 ATOM 1388 CA GLY L 152 20.889 16.313 43.159 1.00 15.70 ATOM 1389 C GLY L 152 21.951 15.745 42.250 1.00 16.31 ATOM 1390 O GLY L 152 22.364 16.424 41.322 1.00 17.83 ATOM 1391 N THRL 153 22.399 14.515 42.476 1.00 18.56 ATOM 1393 CA THR L 153 23.473 13.958 41.634 1.00 18.43 ATOM 1394 CB THRL 153 24.498 13.190 42.480 1.00 19.60 ATOM 1395 OGI THR L 153 23.896 12.012 43.019 1.00 25.85 ATOM 1397 CG2 THR L 153 24.964 14.055 43.650 1.00 23.47 ATOM 1398 C THR L 153 22.904 13.094 40.482 1.00 18.68 ATOM 1399 O THRL 153 21.899 12.393 40.614 1.00 18.23 ATOM 1400 N PRO L 154 23.516 13.173 39.299 1.00 18.73 ATOM 1401 CD PRO L 154 24.730 13.967 38.997 1.00 19.95 ATOM 1402 CA PRO L 154 23.038 12.424 38.120 1.00 18.94 ATOM 1403 CB PRO L 154 23.865 13.030 36.987 1.00 18.59 ATOM 1404 CG PRO L 154 25.150 13.360 37.688 1.00 18.89 ATOM 1405 C PRO L 154 23.196 10.914 38.253 1.00 15.33 ATOM 1406 O PRO L 154 24.232 10.443 38.662 1.00 16.30 ATOM 1407 N VAL L 155 22.150 10.147 37.978 1.00 16.59 ATOM 1409 CA VAL L 155 22.323 8.703 38.040 1.00 19.40 ATOM 1410 CB VAL L 155 21.065 7.962 38.617 1.00 19.34 ATOM 1411 CGI VALL 155 20.124 8.947 39.276 1.00 18.37 ATOM 1412 CG2 VAL L 155 20.353 7.132 37.558 1.00 18.74 ATOM 1413 C VALL 155 22.760 8.141 36.641 1.0021.02 ATOM 1414 OVALL 155 22.397 8.681 35.565 1.00 19.02 ATOM 1415 N THRL 156 23.606 7.121 36.664 1.0022.42 ATOM 1417 CA THRL 156 24.093 6.532 35.438 1.00 23.32 ATOM 1418 CB THRL 156 25.579 6.770 35.317 1.00 23.16 ATOM 1419 OG I THR L 156 26.227 6.276 36.494 1.00 25.01 WO 99/10379 PCT/GB98/02542 -23)3 ATOM 1421 CG2THRL 156 25.845 8.249 35.181 1.00 25.87 ATOM 1422 C THRL 156 23.858 5.049 35.421 1.0025.17 ATOM 1423 O THR L 156 24.327 4.357 34.533 1.00 28.73 ATOM 1424 N GLN L 157 23.119 4.554 36.376 1.0023.46 ATOM 1426 CA GLN L 157 22.909 3.152 36.465 1.0023.50 ATOM 1427 CB GLN L 157 23.954 2.603 37.389 1.0029.55 ATOM 1428 CG GLN L 157 24.032 1.102 37.399 1.00 37.55 ATOM 1429 CD GLN L 157 25.281 0.639 38.106 1.0043.33 ATOM 1430 OEI GLN L 157 25.750 1.288 39.060 1.0043.65 ATOM 1431 NE2 GLN L 157 25.845 -0.472 37.631 1.00 45.54 ATOM 1434 C GLN L 157 21.525 2.871 36.994 1.00 19.92 ATOM 1435 O GLN L 157 21.025 3.631 37.778 1.00 18.81 ATOM 1436 N GLYL 158 20.895 1.817 36.526 1.00 18.99 ATOM 1438 CA GLYL 158 19.569 1.471 37.010 1.0020.19 ATOM 1439 C GLY L 158 18.397 2.250 36.382 1.0022.36 ATOM 1440 O GLYL 158 17.281 2.099 36.815 1.0022.31 ATOM 1441 N METL 159 18.630 3.080 35.374 1.0024.81 ATOM 1443 CA MET L 159 17.539 3.802 34.741 1.0022.88 ATOM 1444 CB METL 159 17.810 5.312 34.684 1.0023.15 ATOM 1445 CG METL 159 18.833 5.795 33.687 1.0026.34 ATOM 1446 SD MET L 159 20.522 5.748 34.304 1.00 34.44 ATOM 1447 CE METL 159 21.030 4.165 33.643 1.0031.53 ATOM 1448 C METL 159 17.277 3.230 33.351 1.0023.01 ATOM 1449 O METL 159 18.188 2.833 32.662 1.0024.49 ATOM 1450 N GLU L 160 16.026 3.169 32.960 1.00 19.49 ATOM 1452 CA GLUL 160 15.670 2.591 31.710 1.00 19.70 ATOM 1453 CB GLU L 160 15.366 1.107 31.939 1.0021.50 ATOM 1454 CG GLU L 160 14.501 0.431 30.913 1.0024.34 ATOM 1455 CD GLU L 160 15.230 0.049 29.644 1.00 30.12 ATOM 1456 OE1 GLUL 160 16.464 -0.184 29.733 1.0028.32 ATOM 1457 OE2 GLU L 160 14.558 -0.021 28.551 1.00 30.69 ATOM 1458 C GLUL 160 14.491 3.326 31.156 1.00 19.64 ATOM 1459 O GLU L 160 13.446 3.366 31.785 1.00 18.31 ATOM 1460 N THRL 161 14.667 3.908 29.959 1.0020.21 ATOM 1462 CA THRL 161 13.611 4.715 29.300 1.00 18.39 ATOM 1463 CB THRL 161 14.163 6.137 28.972 1.00 19.35 ATOM 1464 OGI THRL 161 14.627 6.741 30.188 1.00 15.43 ATOM 1466 CG2THRL 161 13.107 7.025 28.342 1.00 13.84 ATOM 1467 C THRL 161 13.091 4.047 28.007 1.00 18.90 ATOM 1468 O THRL 161 13.859 3.391 27.292 1.00 18.53 ATOM 1469 N THRL 162 11.777 4.198 27.738 1.00 17.02 ATOM 1471 CA THRL 162 11.163 3.603 26.573 1.00 14.46 ATOM 1472 CB THRL 162 9.768 3.023 26.890 1.00 9.31 ATOM 1473 OG1 THR L 162 8.866 4.067 27.336 1.00 8.44 ATOM 1475 CG2 THR L 162 9.880 1.940 27.965 1.00 8.50 ATOM 1476 C THRL 162 11.085 4.614 25.421 1.00 15.09 ATOM 1477 O THRL 162 11.083 5.834 25.624 1.00 14.93 ATOM 1478 N ALAL 163 11.071 4.110 24.200 1.00 12.96 ATOM 1480 CA ALA L 163 11.054 4.983 23.052 1.00 10.76 ATOM 1481 CB ALAL 163 11.434 4.212 21.768 1.00 15.08 ATOM 1482 C ALA L 163 9.719 5.567 22.921 1.00 8.59 ATOM 1483 O ALA L 163 8.749 4.856 23.017 1.00 11.96 ATOM 1484 N PROL 164 9.632 6.894 22.721 1.00 11.37 ATOM 1485 CD PRO L 164 10.762 7.849 22.597 1.00 12.89 ATOM 1486 CA PROL 164 8.352 7.578 22.587 1.00 11.21 ATOM 1487 CB PRO L 164 8.746 8.956 22.069 1.00 11.04 WO 99/10379 PCT/GB98/02542 -234 ATOM 1488 CG PRO L 164 10.047 9.160 22.761 1.00 11.07 ATOM 1489 C PRO L 164 7.488 6.825 21.632 1.00 12.84 ATOM 1490 O PRO L 164 7.986 6.130 20.746 1.00 17.44 ATOM 1491 N SERL 165 6.221 6.878 21.829 1.00 14.17 ATOM 1493 CA SERL 165 5.334 6.188 20.925 1.00 16.08 ATOM 1494 CB SERL 165 4.889 4.810 21.470 1.00 17.01 ATOM 1495 OG SERL 165 3.841 4.922 22.407 1.00 22.35 ATOM 1497 C SERL 165 4.201 7.099 20.724 1.00 15.78 ATOM 1498 O SER L 165 3.927 7.920 21.584 1.00 15.19 ATOM 1499 N LYS L 166 3.588 7.018 19.594 1.00 17.84 ATOM 1501 CA LYS L 166 2.573 7.988 19.257 1.00 19.88 ATOM 1502 CB LYS L 166 2.382 8.012 17.758 1.0022.34 ATOM 1503 CG LYS L 166 2.308 9.398 17.150 1.0021.36 ATOM 1504 CD LYSL 166 2.292 9.300 15.619 1.0025.05 ATOM 1505 CE LYS L 166 2.623 10.640 14.981 0.01 22.27 ATOM 1506 NZ LYS L 166 2.568 10.579 13.495 0.01 22.15 ATOM 1510 C LYS L 166 1.276 7.704 19.925 1.00 21.48 ATOM 1511 0 LYS L 166 0.893 6.547 20.063 1.00 23.82 ATOM 1512 N GLNL 167 0.614 8.770 20.372 1.0020.46 ATOM 1514 CA GLN L 167 -0.716 8.658 20.935 1.00 19.43 ATOM 1515 CB GLNL 167 -0.983 9.729 21.969 1.00 19.09 ATOM 1516 CG GLN L 167 0.047 9.821 23.080 1.00 13.91 ATOM 1517 CD GLNL 167 -0.193 10.992 24.017 1.00 12.43 ATOM 1518 OEI GLNL 167 0.488 11.145 25.066 1.00 12.78 ATOM 1519 NE2GLNL 167 -1.157 11.834 23.670 1.00 12.35 ATOM 1522 C GLN L 167 -1.702 8.865 19.814 1.0020.58 ATOM 1523 O GLNL 167 -1.347 9.393 18.782 1.00 19.43 ATOM 1524 N SER L 168 -2.929 8.494 20.029 1.00 24.20 ATOM 1526 CA SER L 168 -3.955 8.647 19.009 1.00 28.22 ATOM 1527 CB SER L 168 -5.305 8.283 19.615 1.00 29.04 ATOM 1528 OG SER L 168 -5.428 8.880 20.904 1.00 34.62 ATOM 1530 C SERL 168 -3.996 10.085 18.468 1.0030.48 ATOM 1531 O SERL 168 -4.401 10.335 17.308 1.0034.63 ATOM 1532 N ASN L 169 -3.579 11.035 19.279 1.00 26.12 ATOM 1534 CA ASN L 169 -3.644 12.398 18.848 1.00 25.93 ATOM 1535 CB ASNL 169 -4.066 13.329 19.982 1.00 29.63 ATOM 1536 CG ASN L 169 -3.125 13.386 21.158 1.0029.04 ATOM 1537 OD1ASNL 169 -2.107 12.704 21.219 1.0031.37 ATOM 1538 ND2 ASN L 169 -3.479 14.214 22.099 1.00 31.92 ATOM 1541 C ASN L 169 -2.351 12.815 18.283 1.00 25.86 AT OM 1542 O ASN L 169 -2.052 13.991 18.186 1.00 26.70 ATOM 1543 N ASNL 170 -1.578 11.847 17.927 1.0023.96 ATOM 1545 CA ASN L 170 -0.314 12.085 17.286 1.00 23.68 ATOM 1546 CB ASN L 170 -0.543 12.718 15.919 1.00 25.27 ATOM 1547 CG ASNL 170 -1.095 11.647 14.987 1.0028.14 ATOM 1548 ODI ASN L 170 -0.390 10.682 14.651 1.00 30.35 ATOM 1549 ND2ASNL 170 -2.362 11.765 14.614 1.00 29.66 ATOM 1552 C ASNL 170 0.690 12.837 18.108 1.0022.90 ATOM 1553 O ASNL 170 1.720 13.248 17.607 1.0025.60 ATOM 1554 N LYS L 171 0.407 13.049 19.361 1.0021.22 ATOM 1556 CA LYS L 171 1.452 13.524 20.244 1.00 19.04 ATOM 1557 CB LYS L 171 0.888 14.296 21.429 1.00 17.22 ATOM 1558 CG LYS L 171 0.207 15.595 21.112 1.00 17.62 ATOM 1559 CD LYS L 171 -0.340 16.198 22.407 1.00 15.11 ATOM 1560 CE LYS L 171 -1.277 17.358 22.132 1.00 18.27 ATOM 1561 NZ LYS L 171 -1.526 18.187 23.347 1.00 14.34 WO 99/10379 PCT/GB98/02542 -235 ATOM 1565 C LYS L 171 2.140 12.247 20.744 1.00 17.36 ATOM 1566 O LYS L 171 1.728 11.156 20.373 1.00 17.98 ATOM 1567 N TYRL 172 3.132 12.353 21.586 1.00 14.79 ATOM 1569 CA TYRL 172 3.863 11.178 21.976 1.00 14.85 ATOM 1570 CB TYRL 172 5.301 11.331 21.516 1.00 15.82 ATOM 1571 CG TYRL 172 5.451 11.261 20.022 1.00 17.24 ATOM 1572 CDI TYRL 172 5.218 12.372 19.196 1.00 15.15 ATOM 1573 CEl TYRL 172 5.377 12.281 17.812 1.00 18.45 ATOM 1574 CD2 TYRL 172 5.836 10.071 19.427 1.00 17.80 ATOM 1575 CE2TYRL 172 5.995 9.974 18.053 1.0020.12 ATOM 1576 CZ TYRL 172 5.773 11.070 17.242 1.00 18.23 ATOM 1577 OH TYRL 172 5.968 10.945 15.874 1.00 13.35 ATOM 1579 C TYRL 172 3.838 10.907 23.461 1.00 15.41 ATOM 1580 O TYRL 172 3.585 11.820 24.271 1.00 14.17 ATOM 1581 N METL 173 4.111 9.639 23.811 1.00 13.34 ATOM 1583 CA METL 173 4.195 9.241 25.192 1.00 9.55 ATOM 1584 CB METL 173 2.927 8.498 25.600 1.00 10.24 ATOM 1585 CG METL 173 2.767 7.121 24.973 1.00 15.16 ATOM 1586 SD METL 173 1.450 6.149 25.719 1.0020.11 ATOM 1587 CE METL 173 0.045 6.910 24.992 1.00 12.86 ATOM 1588 C METL 173 5.455 8.386 25.429 1.00 10.38 ATOM 1589 O METL 173 6.005 7.778 24.500 1.00 10.40 ATOM 1590 N ALAL 174 5.935 8.354 26.658 1.00 7.39 ATOM 1592 CA ALA L 174 7.131 7.594 27.005 1.00 7.66 ATOM 1593 CB ALAL 174 8.410 8.325 26.532 1.00 4.47 ATOM 1594 C ALAL 174 7.164 7.383 28.521 1.00 8.50 ATOM 1595 O ALA L 174 6.371 7.983 29.240 1.00 7.42 ATOM 1596 N SERL 175 8.055 6.519 28.984 1.00 8.85 ATOM 1598 CA SERL 175 8.163 6.231 30.404 1.00 9.69 ATOM 1599 CB SERL 175 7.275 5.031 30.782 1.00 8.09 ATOM 1600 OG SERL 175 7.633 3.838 30.073 1.00 12.41 ATOM 1602 C SERL 175 9.606 5.949 30.777 1.00 10.11 ATOM 1603 O SERL 175 10.408 5.513 29.919 1.00 9.58 ATOM 1604 N SERL 176 9.975 6.223 32.048 1.00 6.07 ATOM 1606 CA SERL 176 11.313 5.918 32.495 1.00 3.46 ATOM 1607 CB SERL 176 12.179 7.152 32.471 1.00 2.00 ATOM 1608 OG SER L 176 13.547 6.852 32.684 1.00 2.00 ATOM 1610 C SERL 176 11.221 5.305 33.892 1.00 5.39 ATOM 1611 O SERL 176 10.237 5.487 34.558 1.00 7.78 ATOM 1612 N TYRL 177 12.212 4.513 34.237 1.00 6.76 ATOM 1614 CA TYRL 177 12.235 3.758 35.455 1.00 8.12 ATOM 1615 CB TYRL 177 12.051 2.273 35.151 1.00 6.07 ATOM 1616 CG TYRL 177 10.695 1.871 34.600 1.00 6.17 ATOM 1617 CDI TYRL 177 9.630 1.577 35.457 1.00 6.94 ATOM 1618 CEl TYRL 177 8.371 1.231 34.938 1.00 8.14 ATOM 1619 CD2TYRL 177 10.461 1.799 33.224 1.00 6.52 ATOM 1620 CE2TYRL 177 9.212 1.459 32.716 1.00 7.03 ATOM 1621 CZ TYRL 177 8.169 1.178 33.568 1.00 6.45 ATOM 1622 OH TYRL 177 6.901 0.894 33.061 1.00 6.11 ATOM 1624 C TYRL 177 13.560 3.886 36.100 1.00 6.87 ATOM 1625 O TYRL 177 14.563 3.836 35.428 1.00 9.13 ATOM 1626 N LEU L 178 13.558 4.034 37.400 1.00 6.48 ATOM 1628 CA LEU L 178 14.761 3.993 38.156 1.00 6.11 ATOM 1629 CB LEU L 178 14.999 5.312 38.847 1.00 6.46 ATOM 1630 CG LEU L 178 16.228 5.448 39.722 1.00 7.03 ATOM 1631 CDI LEU L 178 17.496 5.055 38.993 1.00 10.30 WO 99/10379 PCT/GB98/02542 -236 ATOM 1632 CD2 LEU L 178 16.308 6.878 40.219 1.00 13.82 ATOM 1633 C LEU L 178 14.618 2.885 39.156 1.00 8.35 ATOM 1634 O LEU L 178 13.687 2.862 39.902 1.00 10.42 ATOM 1635 N THRL 179 15.550 1.969 39.130 1.00 11.56 ATOM 1637 CA THRL 179 15.522 0.802 39.963 1.00 13.47 ATOM 1638 CB THRL 179 15.703 -0.456 39.096 1.00 15.12 ATOM 1639 OG I THR L 179 14.558 -0.594 38.292 1.00 14.73 ATOM 1641 CG2 THR L 179 15.847 -1.722 39.940 1.00 19.56 ATOM 1642 C THRL 179 16.613 0.903 41.008 1.00 16.41 ATOM 1643 O THRL 179 17.808 1.133 40.693 1.00 15.41 ATOM 1644 N LEU L 180 16.177 0.755 42.248 1.00 16.98 ATOM 1646 CA LEU L 180 17.021 0.929 43.383 1.00 17.38 ATOM 1647 CB LEU L 180 16.614 2.210 44.155 1.00 17.62 ATOM 1648 CG LEUL 180 16.667 3.566 43.424 1.00 18.66 ATOM 1649 CDI LEU L 180 16.074 4.662 44.300 1.00 15.82 ATOM 1650 CD2 LEU L 180 18.108 3.926 43.067 1.00 19.60 ATOM 1651 C LEU L 180 16.793 -0.217 44.300 1.00 15.89 ATOM 1652 O LEU L 180 15.742 -0.853 44.241 1.00 20.00 ATOM 1653 N THRL 181 17.766 -0.482 45.130 1.00 16.39 ATOM 1655 CA THRL 181 17.562 -1.407 46.238 1.00 16.84 ATOM 1656 CB THRL 181 18.888 -1.803 46.924 1.00 15.01 ATOM 1657 OGI THRL 181 19.566 -0.615 47.398 1.00 18.96 ATOM 1659 CG2 THR L 181 19.791 -2.578 45.975 1.00 16.62 ATOM 1660 C THR L 181 16.753 -0.634 47.265 1.00 14.44 ATOM 1661 O THRL 181 16.705 0.607 47.201 1.00 16.04 ATOM 1662 N ALA L 182 16.120 -1.307 48.192 1.00 15.12 ATOM 1664 CA ALAL 182 15.421 -0.582 49.249 1.00 13.02 ATOM 1665 CB ALA L 182 14.687 -1.564 50.157 1.00 13.78 ATOM 1666 C ALA L 182 16.427 0.289 50.076 1.00 14.39 ATOM 1667 O ALA L 182 16.111 1.422 50.478 1.00 16.28 ATOM 1668 N ARG L 183 17.645 -0.219 50.307 1.00 14.52 ATOM 1670 CA ARG L 183 18.623 0.535 51.069 1.00 16.24 ATOM 1671 CB ARG L 183 19.894 -0.287 51.295 1.00 19.45 ATOM 1672 CG ARG L 183 21.080 0.527 51.825 1.0024.50 ATOM 1673 CD ARG L 183 22.102 -0.351 52.538 1.00 29.62 ATOM 1674 NE ARG L 183 23.465 0.263 52.582 1.00 35.27 ATOM 1676 CZ ARG L 183 24.403 -0.026 53.535 1.00 35.81 ATOM 1677 NH1 ARG L 183 25.633 0.509 53.470 1.00 35.30 ATOM 1680 NH2 ARG L 183 24.098 -0.817 54.555 1.00 36.43 ATOM 1683 C ARG L 183 18.930 1.869 50.400 1.00 18.26 A'iOM 1684 O ARG L 183 18.887 2.903 51.049 1.00 19.19 ATOM 1685 N ALA L 184 19.195 1.857 49.091 1.00 16.18 ATOM 1687 CA ALA L 184 19.460 3.076 48.392 1.00 10.91 ATOM 1688 CB ALA L 184 19.774 2.735 46.955 1.00 9.98 ATOM 1689 C ALAL 184 18.248 4.012 48.496 1.00 12.19 ATOM 1690 O ALAL 184 18.383 5.227 48.667 1.00 11.01 ATOM 1691 N TRPL 185 17.057 3.453 48.408 1.00 10.53 ATOM 1693 CA TRPL 185 15.851 4.264 48.467 1.00 11.80 ATOM 1694 CB TRPL 185 14.630 3.391 48.243 1.00 11.64 ATOM 1695 CG TRP L 185 13.402 4.062 48.687 1.00 9.64 ATOM 1696 CD2 TRP L 185 12.818 5.261 48.138 1.00 14.47 ATOM 1697 CE2 TRP L 185 11.622 5.500 48.840 1.00 14.89 ATOM 1698 CE3 TRP L 185 13.177 6.149 47.109 1.00 14.90 ATOM 1699 CDI TRP L 185 12.572 3.639 49.683 1.00 15.33 ATOM 1700 NEI TRPL 185 11.511 4.503 49.757 1.00 15.12 ATOM 1702 CZ2TRP L 185 10.783 6.583 48.556 1.00 15.58 WO 99/10379 PCT/GB98/02542 -237 ATOM 1703 CZ3 TRP L 185 12.349 7.209 46.821 1.00 12.52 ATOM 1704 CH2 TRP L 185 11.162 7.419 47.544 1.00 12.84 ATOM 1705 C TRPL 185 15.693 5.024 49.798 1.00 16.85 ATOM 1706 O TRP L 185 15.351 6.222 49.809 1.00 15.42 ATOM 1707 N GLU L 186 15.942 4.343 50.918 1.00 16.92 ATOM 1709 CA GLU L 186 15.757 4.979 52.223 1.00 19.08 ATOM 1710 CB GLUL 186 15.767 3.927 53.332 1.0021.77 ATOM 1711 CG GLU L 186 14.962 2.655 53.073 1.00 25.99 ATOM 1712 CD GLU L 186 15.288 1.566 54.110 0.5026.59 ATOM 1713 OEI GLU L 186 16.183 1.799 54.944 0.50 23.57 ATOM 1714 OE2 GLU L 186 14.663 0.485 54.086 0.50 23.36 ATOM 1715 C GLU L 186 16.871 5.975 52.537 1.00 20.25 ATOM 1716 O GLU L 186 16.733 6.824 53.421 1.0020.91 ATOM 1717 N ARG L 187 17.991 5.852 51.861 1.00 18.94 ATOM 1719 CA ARG L 187 19.129 6.651 52.216 1.00 18.58 ATOM 1720 CB ARG L 187 20.376 5.949 51.760 1.0020.96 ATOM 1721 CG ARG L 187 21.574 6.848 51.702 1.0027.24 ATOM 1722 CD ARG L 187 22.687 6.156 50.972 1.0036.91 ATOM 1723 NE ARGL 187 23.339 5.146 51.793 1.0039.36 ATOM 1725 CZ ARG L 187 24.660 5.032 51.834 1.0042.54 ATOM 1726 NH1 ARGL 187 25.231 4.124 52.607 1.0045.47 ATOM 1729 NH2ARGL 187 25.415 5.827 51.081 1.0046.06 ATOM 1732 C ARG L 187 19.089 8.077 51.671 1.00 18.28 ATOM 1733 O ARG L 187 19.798 8.946 52.176 1.00 20.00 ATOM 1734 N HIS L 188 18.281 8.333 50.647 1.00 17.48 ATOM 1736 CA HIS L 188 18.247 9.674 50.027 1.00 16.15 ATOM 1737 CB HIS L 188 18.559 9.585 48.486 1.00 13.42 ATOM 1738 CG HIS L 188 19.880 8.962 48.214 1.00 14.37 ATOM 1739 CD2 HIS L 188 20.267 7.658 48.229 1.00 15.01 ATOM 1740 NDI HIS L 188 21.060 9.680 48.221 1.00 14.95 ATOM 1742 CE1 HISL 188 22.118 8.897 48.281 1.00 13.98 ATOM 1743 NE2 HIS L 188 21.646 7.663 48.299 1.00 15.86 ATOM 1745 C HIS L 188 16.893 10.318 50.255 1.00 16.60 ATOM 1746 O HIS L 188 15.897 9.614 50.431 1.00 18.56 ATOM 1747 N SERL 189 16.855 11.660 50.285 1.00 18.06 ATOM 1749 CA SERL 189 15.587 12.384 50.467 1.00 17.30 ATOM 1750 CB SERL 189 15.790 13.568 51.425 1.00 20.51 ATOM 1751 OG SERL 189 16.943 14.314 51.086 1.00 18.48 ATOM 1753 C SERL 189 15.038 12.891 49.144 1.00 18.08 ATOM 1754 O SERL 189 13.827 12.891 48.917 1.0021.50 ATOM 1755 N SERL 190 15.942 13.272 48.248 1.00 17.95 ATOM 1757 CA SERL 190 15.557 13.876 46.968 1.00 17.18 ATOM 1758 CB SERL 190 16.428 15.100 46.714 1.00 14.84 ATOM 1759 OG SERL 190 15.884 15.885 45.679 1.00 24.95 ATOM 1761 C SERL 190 15.684 12.922 45.798 1.00 15.72 ATOM 1762 O SER L 190 16.726 12.282 45.606 1.00 16.39 ATOM 1763 N TYRL 191 14.629 12.845 45.031 1.00 15.74 ATOM 1765 CA TYRL 191 14.623 12.054 43.793 1.00 18.47 ATOM 1766 CB TYRL 191 13.878 10.730 44.016 1.0020.26 ATOM 1767 CG TYRL 191 14.562 9.836 45.023 1.0020.87 ATOM 1768 CDI TYRL 191 15.601 9.008 44.611 1.0023.39 ATOM 1769 CEl TYR L 191 16.300 8.219 45.503 1.00 22.95 ATOM 1770 CD2TYRL 191 14.217 9.856 46.395 1.0024.18 ATOM 1771 CE2 TYR L 191 14.919 9.060 47.302 1.00 26.25 ATOM 1772 CZ TYRL 191 15.972 8.245 46.835 1.0026.73 ATOM 1773 OH TYR L 191 16.740 7.505 47.709 1.00 30.08 WO 99/10379 PCT/GB98/02542 -238 ATOM 1775 C TYR L 191 13.939 12.880 42.683 1.00 17.55 ATOM 1776 O TYRL 191 12.923 13.505 42.929 1.00 14.74 ATOM 1777 N SER L 192 14.477 12.883 41.464 1.00 16.33 ATOM 1779 CA SERL 192 13.909 13.741 40.451 1.00 15.90 ATOM 1780 CB SERL 192 14.734 15.031 40.432 1.00 18.03 ATOM 1781 OG SERL 192 14.167 15.951 39.536 1.0023.10 ATOM 1783 C SERL 192 13.938 13.135 39.071 1.00 12.29 ATOM 1784 O SERL 192 14.958 12.641 38.661 1.00 14.68 ATOM 1785 N CYS L 193 12.839 13.208 38.359 1.00 11.59 ATOM 1787 CA CYS L 193 12.832 12.817 36.950 1.00 14.23 ATOM 1788 CB CYS L 193 11.604 11.985 36.621 1.00 15.78 ATOM 1789 SG CYS L 193 11.540 11.360 34.913 1.00 15.09 ATOM 1790 C CYS L 193 12.834 14.075 36.093 1.00 12.46 ATOM 1791 O CYSL 193 11.918 14.867 36.192 1.00 14.42 ATOM 1792 N GLN L 194 13.849 14.261 35.247 1.00 14.04 ATOM 1794 CA GLN L 194 13.936 15.485 34.450 1.00 14.30 ATOM 1795 CB GLN L 194 15.225 16.209 34.730 1.0020.47 ATOM 1796 CG GLN L 194 15.471 16.453 36.182 1.0026.89 ATOM 1797 CD GLN L 194 16.704 17.282 36.393 1.00 33.09 ATOM 1798 OE1 GLN L 194 16.913 17.828 37.488 1.00 36.67 ATOM 1799 NE2 GLN L 194 17.538 17.392 35.352 1.00 36.22 ATOM 1802 C GLN L 194 13.873 15.200 32.978 1.00 13.96 ATOM 1803 O GLNL 194 14.730 14.526 32.449 1.00 11.43 ATOM 1804 N VALL 195 12.867 15.763 32.335 1.00 13.39 ATOM 1806 CA VALL 195 12.608 15.511 30.936 1.00 15.15 ATOM 1807 CB VALL 195 11.165 15.065 30.770 1.00 13.26 ATOM 1808 CG1 VALL 195 10.866 14.807 29.311 1.00 12.28 ATOM 1809 CG2 VAL L 195 10.902 13.839 31.643 1.00 8.74 ATOM 1810 C VALL 195 12.823 16.764 30.072 1.00 16.35 ATOM 1811 0 VALL 195 12.012 17.702 30.111 1.00 15.34 ATOM 1812 N THRL 196 13.904 16.763 29.295 1.00 16.92 ATOM 1814 CA THRL 196 14.192 17.876 28.379 1.00 15.93 ATOM 1815 CB THRL 196 15.716 17.992 28.176 1.00 18.12 ATOM 1816 OGI THRL 196 16.349 18.183 29.443 1.00 22.55 ATOM 1818 CG2THRL 196 16.071 19.156 27.273 1.0021.24 ATOM 1819 C THRL 196 13.507 17.647 27.035 1.00 16.18 ATOM 1820 O THRL 196 13.746 16.598 26.400 1.00 14.99 ATOM 1821 N HIS L 197 12.638 18.625 26.619 1.00 14.43 ATOM 1823 CA HIS L 197 11.923 18.563 25.348 1.00 13.60 ATOM 1824 CB HIS L 197 10.429 18.345 25.566 1.00 12.56 ATOM 1825 CG HIS L 197 9.581 18.336 24.308 1.00 9.47 ATOM 1826 CD2 HIS L 197 9.549 17.479 23.275 1.00 8.75 ATOM 1827 NDI HIS L 197 8.492 19.191 24.088 1.00 13.69 ATOM 1829 CE1 HIS L 197 7.842 18.873 22.994 1.00 10.65 ATOM 1830 NE2 HIS L 197 8.472 17.842 22.506 1.00 13.24 ATOM 1832 C HIS L 197 12.084 19.882 24.607 1.00 19.15 ATOM 1833 O HIS L 197 11.393 20.882 24.950 1.00 21.46 ATOM 1834 N GLUL 198 12.900 19.865 23.560 1.00 19.88 ATOM 1836 CA GLU L 198 13.180 21.058 22.766 1.0023.30 ATOM 1837 CB GLUL 198 11.899 21.642 22.147 1.0025.45 ATOM 1838 CG GLUL 198 11.076 20.681 21.322 1.0025.96 ATOM 1839 CD GLU L 198 11.425 20.689 19.856 1.00 29.67 ATOM 1840 OE1 GLU L 198 12.387 19.979 19.468 1.0031.64 ATOM 1841 OE2GLUL 198 10.725 21.393 19.086 1.0027.15 ATOM 1842 C GLU L 198 13.834 22.126 23.630 1.0025.19 ATOM 1843 O GLUL 198 13.366 23.251 23.670 1.0025.37 WO 99/10379 PCT/GB98/02542 -239 ATOM 1844 N GLY L 199 14.863 21.742 24.369 1.0026.71 ATOM 1846 CA GLYL 199 15.636 22.709 25.110 1.0028.67 ATOM 1847 C GLY L 199 15.019 23.191 26.406 1.00 30.20 ATOM 1848 O GLY L 199 15.623 24.028 27.078 1.00 31.36 ATOM 1849 N HIS L200 13.825 22.693 26.755 1.00 29.31 ATOM 1851 CA HIS L200 13.168 23.108 27.996 1.0029.70 ATOM 1852 CB HIS L 200 11.793 23.766 27.747 1.0034.13 ATOM 1853 CG HIS L 200 11.620 24.410 26.399 1.0042.18 ATOM 1854 CD2 HIS L 200 12.517 24.952 25.533 1.00 44.52 ATOM 1855 NDI HIS L 200 10.401 24.456 25.729 1.00 45.60 ATOM 1857 CEI HIS L200 10.537 24.971 24.507 1.0046.26 ATOM 1858 NE2HIS L 200 11.811 25.274 24.385 1.0046.19 ATOM 1860 C HIS L 200 12.960 21.888 28.849 1.00 27.60 ATOM 1861 O HIS L 200 12.335 20.927 28.385 1.00 27.65 ATOM 1862 N THR L 201 13.457 21.938 30.084 1.0027.03 ATOM 1864 CA THR L 201 13.372 20.796 30.993 1.0025.96 ATOM 1865 CB THR L 201 14.635 20.732 31.874 1.0022.54 ATOM 1866 OG1 THR L 201 15.758 20.710 31.032 1.0021.22 ATOM 1868 CG2 THR L 201 14.693 19.477 32.724 1.00 22.94 ATOM 1869 C THR L 201 12.108 20.846 31.863 1.0026.78 ATOM 1870 O THR L 201 11.847 21.857 32.522 1.0029.53 ATOM 1871 N VAL L 202 11.279 19.777 31.789 1.0025.81 ATOM 1873 CA VAL L 202 10.124 19.623 32.694 1.0022.79 ATOM 1874 CB VAL L 202 8.881 19.138 31.929 1.0024.16 ATOM 1875 CG1 VAL L 202 7.668 19.067 32.862 1.00 24.52 ATOM 1876 CG2VAL L 202 8.612 20.091 30.773 1.0024.14 ATOM 1877 C VAL L 202 10.507 18.598 33.784 1.0021.74 ATOM 1878 0 VAL L 202 10.960 17.519 33.480 1.00 19.01 ATOM 1879 N GLU L 203 10.340 18.934 35.055 1.0020.40 ATOM 1881 CA GLU L 203 10.807 18.063 36.086 1.00 19.67 ATOM 1882 CB GLU L 203 12.045 18.700 36.717 1.00 22.14 ATOM 1883 CG GLU L 203 12.600 17.919 37.883 1.0027.78 ATOM 1884 CD GLU L 203 13.320 18.803 38.886 0.5030.15 ATOM 1885 OEI GLU L 203 14.564 18.934 38.777 0.50 30.52 ATOM 1886 OE2 GLU L 203 12.636 19.369 39.785 0.50 30.93 ATOM 1887 C GLU L 203 9.760 17.754 37.162 1.00 18.69 ATOM 1888 O GLU L 203 8.894 18.569 37.477 1.00 19.41 ATOM 1889 N LYS L 204 9.814 16.550 37.679 1.00 16.36 ATOM 1891 CA LYS L 204 9.046 16.210 38.837 1.00 14.59 ATOM 1892 CB LYS L204 7.953 15.262 38.527 1.00 15.55 AIOM 1893 CG LYS L 204 6.869 15.915 37.724 1.0021.54 ATOM 1894 CD LYS L 204 6.405 17.166 38.415 1.0021.69 ATOM 1895 CE LYS L 204 5.248 17.766 37.666 1.0022.39 ATOM 1896 NZ LYS L 204 4.040 16.962 37.885 1.0020.85 ATOM 1900 C LYS L 204 9.977 15.621 39.853 1.00 15.55 ATOM 1901 O LYS L204 11.004 14.995 39.505 1.00 13.34 ATOM 1902 N SER L 205 9.650 15.852 41.124 1.00 17.28 ATOM 1904 CA SER L 205 10.512 15.428 42.198 1.00 16.96 ATOM 1905 CB SERL 205 11.296 16.622 42.760 1.00 18.69 ATOM 1906 OG SER L 205 12.404 16.972 41.916 1.00 25.46 ATOM 1908 C SERL 205 9.722 14.826 43.299 1.00 16.29 ATOM 1909 O SER L 205 8.568 15.117 43.445 1.00 12.40 ATOM 1910 N LEU L 206 10.389 13.967 44.035 1.00 17.28 ATOM 1912 CA LEU L 206 9.856 13.360 45.233 1.00 20.60 ATOM 1913 CB LEU L 206 9.911 11.825 45.136 1.00 18.66 ATOM 1914 CG LEU L 206 9.048 11.160 44.061 1.00 17.51 WO 99/10379 PCT/GB98/02542 -240 ATOM 1915 CDI LEU L 206 9.516 9.738 43.844 1.00 19.23 ATOM 1916 CD2 LEU L206 7.572 11.192 44.444 1.00 16.04 ATOM 1917 C LEU L 206 10.746 13.776 46.393 1.0022.29 ATOM 1918 O LEU L 206 11.965 13.812 46.254 1.0020.72 ATOM 1919 N SER L 207 10.140 14.155 47.487 1.0026.92 ATOM 1921 CA SER L 207 10.896 14.355 48.713 1.00 33.08 ATOM 1922 CB SER L 207 10.498 15.640 49.434 1.00 32.95 ATOM 1923 OG SER L 207 11.247 15.787 50.628 1.0035.61 ATOM 1925 C SER L 207 10.579 13.157 49.602 1.0035.86 ATOM 1926 O SER L 207 9.404 12.760 49.734 1.0038.31 ATOM 1927 N ARG L 208 11.601 12.563 50.163 1.00 36.32 ATOM 1929 CA ARG L 208 11.422 11.391 50.979 1.00 36.19 ATOM 1930 CB ARG L 208 12.255 10.230 50.361 1.00 33.25 ATOM 1931 CG ARG L 208 11.930 8.860 50.912 1.0031.97 ATOM 1932 CD ARG L 208 13.184 8.107 51.300 1.0032.82 ATOM 1933 NE ARG L 208 13.021 7.329 52.540 1.00 37.28 ATOM 1935 CZ ARG L 208 13.846 7.478 53.597 1.0043.16 ATOM 1936 NHI ARG L208 13.703 6.735 54.711 1.00 43.30 ATOM 1939 NH2 ARG L208 14.811 8.395 53.547 1.0045.46 ATOM 1942 C ARG L 208 11.840 11.779 52.420 1.00 37.35 ATOM 1943 OT1ARG L 208 12.794 11.173 52.989 1.0038.30 ATOM 1944 OT2 ARG L 208 11.231 12.763 52.940 1.00 37.56 ATOM 1945 CB ALA H 1 -0.820 -5.033 -4.579 1.00 35.02 ATOM 1946 C ALA H 1 1.166 -6.495 -4.905 1.00 32.62 ATOM 1947 O ALA H 1 0.782 -7.582 -4.499 1.00 32.59 ATOM 1950 N ALA H 1 -0.539 -6.302 -6.690 1.00 37.70 ATOM 1952 CA ALA H 1 0.184 -5.565 -5.595 1.00 34.79 ATOM 1953 N VAL H 2 2.419 -6.048 -4.790 1.0029.87 ATOM 1955 CA VAL H 2 3.463 -6.829 -4.153 1.00 28.68 ATOM 1956 CB VALH 2 4.803 -6.111 -4.242 1.0027.24 ATOM 1957 CG1 VALH 2 5.901 -6.933 -3.589 1.00 30.14 ATOM 1958 CG2 VALH 2 5.116 -5.835 -5.701 1.00 30.41 ATOM 1959 C VALH 2 3.149 -7.059 -2.701 1.00 27.59 ATOM 1960 0 VAL H 2 2.553 -6.216 -2.033 1.0027.26 ATOM 1961 N GLN H 3 3.531 -8.199 -2.220 1.0025.47 ATOM 1963 CA GLN H 3 3.343 -8.497 -0.838 1.0024.24 ATOM 1964 CB GLN H 3 1.917 -9.019 -0.574 1.0026.56 ATOM 1965 CG GLN H 3 1.653 -9.370 0.912 1.00 33.26 ATOM 1966 CD GLN H 3 0.397 -10.222 1.180 1.00 38.06 ATOM 1967 OE1 GLN H 3 0.071 -11.150 0.423 1.0040.20 ATOM 1968 NE2 GLN H 3 -0.306 -9.919 2.289 1.00 38.60 ATOM 1971 C GLN H 3 4.357 -9.524 -0.384 1.00 21.45 ATOM 1972 O GLN H 3 4.500 -10.565 -1.013 1.00 22.59 ATOM 1973 N LEU H 4 5.102 -9.185 0.652 1.00 19.37 ATOM 1975 CA LEUH 4 5.999-10.140 1.312 1.00 16.61 ATOM 1976 CB LEU H 4 7.398 -9.539 1.501 1.00 13.50 ATOM 1977 CG LEU H 4 8.171 -9.234 0.201 1.00 8.19 ATOM 1978 CD1 LEU H 4 9.498 -8.580 0.509 1.00 3.80 ATOM 1979 CD2 LEU H 4 8.404 -10.519 -0.575 1.00 8.33 ATOM 1980 C LEU H 4 5.379 -10.490 2.673 1.00 15.88 ATOM 1981 O LEU H 4 4.921 -9.604 3.387 1.00 15.82 ATOM 1982 N GLNH 5 5.342-11.758 3.027 1.00 14.17 ATOM 1984 CA GLNH 5 4.665-12.158 4.271 1.00 15.42 ATOM 1985 CB GLN H 5 3.297 -12.694 3.909 1.00 16.35 ATOM 1986 CG GLN H 5 2.309 -12.889 5.034 1.00 22.48 ATOM 1987 CD GLN H 5 1.010 -13.514 4.506 1.00 29.57 WO 99/10379 PCT/GB98/02542 -241 ATOM 1988 OEl GLN H 5 0.404 -14.362 5.167 1.00 35.66 ATOM 1989 NE2 GLN H 5 0.575-13.126 3.295 1.0031.58 ATOM 1992 C GLN H 5 5.480 -13.205 5.006 1.00 13.97 ATOM 1993 O GLN H 5 5.597 -14.352 4.546 1.00 9.52 ATOM 1994 N GLU H 6 6.070 -12.798 6.134 1.00 13.08 ATOM 1996 CA GLU H 6 6.934 -13.696 6.901 1.00 9.47 ATOM 1997 CB GLU H 6 7.857 -12.941 7.828 1.00 9.95 ATOM 1998 CG GLU H 6 8.818 -12.002 7.134 1.00 9.95 ATOM 1999 CD GLU H 6 8.227 -10.652 6.796 1.00 5.17 ATOM 2000 OEI GLU H 6 9.024 -9.769 6.455 1.00 8.80 ATOM 2001 OE2 GLU H 6 6.969 -10.462 6.840 1.00 4.90 ATOM 2002 C GLU H 6 6.109 -14.632 7.730 1.00 12.71 ATOM 2003 O GLU H 6 4.908 -14.417 7.907 1.00 13.94 ATOM 2004 N SERH 7 6.772-15.648 8.266 1.00 13.48 ATOM 2006 CA SERH 7 6.122-16.647 9.092 1.00 13.96 ATOM 2007 CB SERH 7 5.433 -17.672 8.201 1.00 15.10 ATOM 2008 OG SERH 7 4.111 -17.308 8.015 1.00 23.26 ATOM 2010 C SER H 7 7.122 -17.398 9.914 1.00 12.29 ATOM 2011 0 SERH 7 8.286-17.424 9.582 1.00 13.84 ATOM 2012 N GLY H 8 6.633 -18.079 10.951 1.00 12.53 ATOM 2014 CA GLYH 8 7.470-19.010 11.664 1.00 10.51 ATOM 2015 C GLYH 8 8.102-18.466 12.905 1.00 12.14 ATOM 2016 O GLY H 8 8.796 -19.199 13.565 1.00 16.56 ATOM 2017 N GLYH 9 7.891-17.195 13.244 1.00 10.59 ATOM 2019 CA GLY H 9 8.519 -16.693 14.462 1.00 14.05 ATOM 2020 C GLY H 9 7.917 -17.287 15.762 1.00 16.57 ATOM 2021 O GLY H 9 6.760 -17.790 15.781 1.00 17.72 ATOM 2022 N GLY H 10 8.670 -17.207 16.848 1.00 16.58 ATOM 2024 CA GLYH 10 8.148-17.666 18.134 1.00 15.33 ATOM 2025 C GLYH 10 9.138-17.451 19.225 1.00 12.28 ATOM 2026 O GLYH 10 10.157-16.779 19.006 1.00 11.60 ATOM 2027 N LEU H 11 8.830 -18.039 20.393 1.00 13.95 ATOM 2029 CA LEU H 11 9.698 -17.991 21.604 1.00 14.48 ATOM 2030 CB LEU H 11 8.808 -18.086 22.841 1.00 14.29 ATOM 2031 CG LEU H 11 9.212 -17.437 24.171 1.00 13.64 ATOM 2032 CD1 LEU H 11 8.438 -18.173 25.257 1.00 13.85 ATOM 2033 CD2 LEU H 11 10.709-17.464 24.470 1.00 4.07 ATOM 2034 C LEU H 11 10.568-19.230 21.585 1.00 14.46 ATOM 2035 O LEU H 11 10.064-20.286 21.346 1.00 15.77 ATOM 2036 N VALH 12 11.839-19.104 21.907 1.00 18.00 ATOM 2038 CA VALH 12 12.751 -20.224 21.891 1.00 15.52 ATOM 2039 CB VALH 12 13.407-20.306 20.461 1.00 18.43 ATOM 2040 CGI VAL H 12 14.920-20.197 20.558 1.00 13.84 ATOM 2041 CG2 VAL H 12 13.000 -21.593 19.746 1.00 16.77 ATOM 2042 C VAL H 12 13.825 -20.016 22.989 1.00 15.38 ATOM 2043 0 VAL H 12 14.178 -18.879 23.340 1.00 13.69 ATOM 2044 N GLN H 13 14.336 -21.091 23.567 1.00 16.57 ATOM 2046 CA GLN H 13 15.365 -20.936 24.581 1.00 15.98 ATOM 2047 CB GLN H 13 15.307 -22.086 25.580 1.00 19.24 ATOM 2048 CG GLN H 13 14.095 -22.089 26.528 1.00 26.05 ATOM 2049 CD GLN H 13 14.433 -22.626 27.933 1.0028.25 ATOM 2050 OEI GLN H 13 15.448 -23.315 28.141 1.0031.14 ATOM 2051 NE2 GLN H 13 13.591 -22.299 28.915 1.00 33.04 ATOM 2054 C GLN H 13 16.710 -20.932 23.907 1.00 14.00 ATOM 2055 O GLN H 13 16.827 -21.336 22.748 1.00 15.42 ATOM 2056 N PRO H 14 17.718-20.384 24.524 1.00 12.23 WO 99/10379 PCT/GB98/02542 -242 ATOM 2057 CD PRO H 14 17.678 -19.542 25.718 1.00 12.38 ATOM 2058 CA PRO H 14 19.033 -20.406 23.936 1.00 12.75 ATOM 2059 CB PRO H 14 19.910 -19.799 25.013 1.00 10.09 ATOM 2060 CG PRO H 14 18.968 -18.787 25.569 1.00 13.06 ATOM 2061 C PRO H 14 19.388 -21.846 23.592 1.00 14.12 ATOM 2062 O PRO H 14 19.071 -22.767 24.361 1.00 16.21 ATOM 2063 N GLY H 15 20.018 -22.031 22.424 1.00 10.07 ATOM 2065 CA GLY H 15 20.307 -23.367 21.913 1.00 7.80 ATOM 2066 C GLY H 15 19.223 -23.801 20.950 1.00 5.91 ATOM 2067 O GLY H 15 19.386-24.766 20.199 1.00 6.43 ATOM 2068 N GLY H 16 18.140 -23.060 20.939 1.00 2.35 ATOM 2070 CA GLY H 16 17.015 -23.419 20.123 1.00 6.43 ATOM 2071 C GLYH 16 17.257-23.299 18.610 1.00 6.38 ATOM 2072 O GLY H 16 18.252 -22.759 18.149 1.00 6.92 ATOM 2073 N SER H 17 16.260 -23.700 17.869 1.00 12.18 ATOM 2075 CA SERH 17 16.315 -23.739 16.416 1.00 11.41 ATOM 2076 CB SERH 17 16.721 -25.170 16.065 1.00 15.73 ATOM 2077 OG SERH 17 16.994-25.349 14.706 1.0022.31 ATOM 2079 C SERH 17 14.907-23.420 15.869 1.00 12.78 ATOM 2080 O SER H 17 13.922 -23.816 16.484 1.00 16.32 ATOM 2081 N MET H 18 14.790 -22.664 14.769 1.00 8.79 ATOM 2083 CA METH 18 13.498-22.456 14.119 1.00 10.28 ATOM 2084 CB MET H 18 12.582-21.425 14.819 1.00 13.63 ATOM 2085 CG METH 18 13.212-20.131 15.329 1.00 16.88 ATOM 2086 SD METH 18 12.014-19.091 16.241 1.0027.06 ATOM 2087 CE METH 18 10.544-20.141 16.251 1.00 3.15 ATOM 2088 C METH 18 13.678-22.055 12.669 1.00 9.07 ATOM 2089 O MET H 18 14.753 -21.621 12.252 1.00 10.49 ATOM 2090 N LYSH 19 12.630-22.199 11.905 1.00 10.93 ATOM 2092 CA LYS H 19 12.683 -21.822 10.529 1.00 11.83 ATOM 2093 CB LYS H 19 12.600 -23.061 9.621 1.00 14.90 ATOM 2094 CG LYS H 19 12.550 -22.781 8.090 1.00 17.52 ATOM 2095 CD LYS H 19 13.032 -23.996 7.304 1.0020.23 ATOM 2096 CE LYS H 19 12.542 -24.031 5.860 1.00 19.51 ATOM 2097 NZ LYS H 19 11.259-24.781 5.747 1.0022.58 ATOM 2101 C LYSH 19 11.578-20.848 10.212 1.00 13.18 ATOM 2102 O LYS H 19 10.407 -21.070 10.524 1.00 12.84 ATOM 2103 N LEUH 20 11.994-19.744 9.604 1.00 12.76 ATOM 2105 CA LEU H 20 11.101-18.717 9.170 1.00 9.79 ATOM 2106 CB LEU H 20 11.715-17.332 9.456 1.00 11.85 ATOM 2107 CG LEU H 20 12.256 -17.078 10.883 1.00 9.81 ATOM 2108 CD1 LEU H 20 12.803 -15.654 10.965 1.00 4.16 ATOM 2109 CD2 LEU H 20 11.165 -17.325 11.928 1.00 4.65 ATOM 2110 C LEU H 20 10.864 -18.860 7.681 1.00 9.78 ATOM 2111 O LEUH 20 11.728-19.320 6.927 1.00 8.56 ATOM 2112 N SERH 21 9.704-18.485 7.288 1.00 9.36 ATOM 2114 CA SERH 21 9.321 -18.533 5.915 1.00 13.01 ATOM 2115 CB SERH 21 8.273 -19.604 5.717 1.00 14.00 ATOM 2116 OG SERH 21 8.807-20.875 6.012 1.00 19.15 ATOM 2118 C SERH 21 8.766-17.205 5.473 1.00 13.78 ATOM 2119 0 SERH 21 8.163-16.482 6.268 1.00 18.18 ATOM 2120 N CYS H 22 8.997 -16.872 4.199 1.00 16.70 ATOM 2122 CA CYS H 22 8.489-15.640 3.604 1.00 13.01 ATOM 2123 CB CYS H 22 9.587 -14.560 3.529 1.00 11.58 ATOM 2124 SG CYSH 22 9.150-13.158 2.425 1.00 13.80 ATOM 2125 C CYS H 22 7.995 -15.917 2.193 1.00 11.47 WO 99/10379 PCT/GB98/02542 -243 ATOM 2126 O CYSH 22 8.718-16.418 1.374 1.00 13.22 ATOM 2127 N VAL H 23 6.773 -15.589 1.935 1.00 14.16 ATOM 2129 CA VAL H 23 6.195 -15.809 0.631 1.00 16.31 ATOM 2130 CB VAL H 23 4.871 -16.609 0.733 1.00 17.85 ATOM 2131 CG1 VALH 23 5.162-17.918 1.444 1.0021.18 ATOM 2132 CG2VALH 23 3.811 -15.831 1.493 1.00 19.36 ATOM 2133 C VAL H 23 5.927 -14.486 -0.033 1.00 16.44 ATOM 2134 0 VAL H 23 5.313 -13.580 0.565 1.00 12.06 ATOM 2135 N ALA H 24 6.385 -14.400 -1.280 1.00 19.48 ATOM 2137 CA ALAH 24 6.247-13.181 -2.088 1.00 19.91 ATOM 2138 CB ALA H 24 7.568 -12.903 -2.774 1.00 18.96 ATOM 2139 C ALAH 24 5.143-13.311 -3.132 1.0021.31 ATOM 2140 O ALA H 24 4.881 -14.410 -3.666 1.0024.23 ATOM 2141 N SERH 25 4.488-12.222 -3.434 1.00 19.69 ATOM 2143 CA SER H 25 3.474-12.266 -4.447 1.00 20.48 ATOM 2144 CB SERH 25 2.151 -12.592 -3.804 1.00 19.79 ATOM 2145 OG SERH 25 1.844-11.601 -2.853 1.0022.03 ATOM 2147 C SERH 25 3.379-10.931 -5.124 1.0020.75 ATOM 2148 O SERH 25 3.861 -9.929 -4.589 1.00 20.32 ATOM 2149 N GLY H 26 2.745 -10.910 -6.292 1.00 22.48 ATOM 2151 CA GLY H 26 2.518 -9.640 -6.979 1.00 24.12 ATOM 2152 C GLYH 26 3.711 -9.128 -7.798 1.0025.02 ATOM 2153 O GLY H 26 3.707 -7.958 -8.219 1.0022.99 ATOM 2154 N PHE H 27 4.720-10.012 -8.005 1.0024.04 ATOM 2156 CA PHEH 27 5.913 -9.716 -8.804 1.0022.13 ATOM 2157 CB PHEH 27 6.808 -8.655 -8.126 1.0023.23 ATOM 2158 CG PHEH 27 7.717 -9.176 -7.022 1.0020.65 ATOM 2159 CDI PHE H 27 9.094 -9.334 -7.249 1.00 19.81 ATOM 2160 CD2 PHE H 27 7.213 -9.450 -5.750 1.00 19.64 ATOM 2161 CE1 PHE H 27 9.940 -9.755 -6.225 1.00 18.67 ATOM 2162 CE2 PHE H 27 8.061 -9.857 -4.730 1.00 16.42 ATOM 2163 CZ PHE H 27 9.416-10.009 -4.964 1.00 16.29 ATOM 2164 C PHEH 27 6.718-11.005 -9.015 1.0022.10 ATOM 2165 O PHE H 27 6.502 -12.018 -8.322 1.00 25.47 ATOM 2166 N THRH 28 7.682-10.944 -9.919 1.00 17.46 ATOM 2168 CA THR H 28 8.478 -12.086 -10.239 1.00 16.95 ATOM 2169 CB THRH 28 9.042-11.939-11.629 1.00 18.84 ATOM 2170 OG1 THRH 28 7.933 -11.701 -12.512 1.00 19.87 ATOM 2172 CG2THRH 28 9.787-13.199-12.039 1.00 17.78 ATOM 2173 C THRH 28 9.588-12.303 -9.265 1.00 16.32 ATOM 2174 O THR H 28 10.746-11.886 -9.500 1.00 13.29 ATOM 2175 N PHE H 29 9.237 -13.018 -8.187 1.00 17.39 ATOM 2177 CA PHEH 29 10.182-13.315 -7.097 1.00 12.65 ATOM 2178 CB PHEH 29 9.507-14.279 -6.097 1.00 14.38 ATOM 2179 CG PHEH 29 10.397-14.838 -5.015 1.00 13.29 ATOM 2180 CDI PHEH 29 10.551 -14.153 -3.797 1.00 17.17 ATOM 2181 CD2 PHE H 29 11.053 -16.054 -5.178 1.00 11.79 ATOM 2182 CE1 PHEH 29 11.356-14.678 -2.770 1.00 16.24 ATOM 2183 CE2PHEH 29 11.856-16.589 -4.162 1.00 8.50 ATOM 2184 CZ PHEH 29 12.012-15.903 -2.965 1.00 14.16 ATOM 2185 C PHEH 29 11.474-13.895 -7.603 1.00 11.31 ATOM 2186 O PHEH 29 12.546-13.535 -7.107 1.00 11.15 ATOM 2187 N SERH 30 11.384-14.789 -8.634 1.00 10.88 ATOM 2189 CA SERH 30 12.574-15.473 -9.198 1.00 10.24 ATOM 2190 CB SERH 30 12.135-16.414-10.355 1.00 10.59 ATOM 2191 OG SER H 30 10.724-16.474-10.445 1.00 20.09 WO 99/10379 PCT/GB98/02542 -244 ATOM 2193 C SERH 30 13.663 -14.525 -9.728 1.00 8.21 ATOM 2194 O SERH 30 14.843 -14.915 -9.841 1.00 6.56 ATOM 2195 N ASNH 31 13.251-13.294-10.108 1.00 10.86 ATOM 2197 CA ASNH 31 14.160-12.317-10.733 1.00 10.45 ATOM 2198 CB ASNH 31 13.370-11.295-11.558 1.00 13.88 ATOM 2199 CG ASNH 31 12.872-11.818-12.880 1.00 17.90 ATOM 2200 ODI ASN H 31 13.232 -12.928 -13.299 1.00 17.77 ATOM 2201 ND2ASNH 31 12.031 -11.021 -13.543 1.0020.48 ATOM 2204 C ASNH 31 15.023-11.519 -9.758 1.00 11.11 ATOM 2205 O ASNH 31 15.975-10.849-10.191 1.00 11.57 ATOM 2206 N TYRH 32 14.675 -11.517 -8.473 1.00 10.42 ATOM 2208 CA TYRH 32 15.442-10.727 -7.515 1.00 7.72 ATOM 2209 CB TYRH 32 14.550 -9.654 -6.923 1.00 10.35 ATOM 2210 CG TYRH 32 13.981 -8.740 -7.960 1.00 10.12 ATOM 2211 CDI TYRH 32 12.704 -8.983 -8.463 1.00 11.35 ATOM 2212 CEI TYRH 32 12.183 -8.238 -9.523 1.00 13.96 ATOM 2213 CD2 TYR H 32 14.743 -7.719 -8.533 1.00 10.05 ATOM 2214 CE2TYRH 32 14.228 -6.955 -9.615 1.00 10.42 ATOM 2215 CZ TYRH 32 12.946 -7.222-10.097 1.00 13.65 ATOM 2216 OH TYRH 32 12.371 -6.438-11.090 1.00 13.93 ATOM 2218 C TYR H 32 16.056-11.540 -6.386 1.00 8.75 ATOM 2219 O TYRH 32 15.547-12.606 -6.002 1.00 8.92 ATOM 2220 N TRPH 33 17.167-11.022 -5.866 1.00 7.78 ATOM 2222 CA TRPH 33 17.751 -11.575 -4.714 1.00 6.34 ATOM 2223 CB TRPH 33 19.104-10.957 -4.367 1.00 3.32 ATOM 2224 CG TRPH 33 20.137-10.913 -5.428 1.00 5.31 ATOM 2225 CD2 TRP H 33 21.483 -10.438 -5.249 1.00 2.32 ATOM 2226 CE2TRPH 33 22.117-10.500 -6.509 1.00 3.83 ATOM 2227 CE3 TRP H 33 22.201 -9.970 -4.150 1.00 5.74 ATOM 2228 CD1 TRPH 33 19.998 -11.243 -6.757 1.00 2.00 ATOM 2229 NE1 TRPH 33 21.186-10.988 -7.387 1.00 3.99 ATOM 2231 CZ2TRPH 33 23.426-10.096 -6.703 1.00 5.36 ATOM 2232 CZ3 TRP H 33 23.503 -9.568 -4.337 1.00 8.48 ATOM 2233 CH2 TRP H 33 24.101 -9.632 -5.608 1.00 7.99 ATOM 2234 C TRP H 33 16.821 -11.212 -3.557 1.00 8.26 ATOM 2235 O TRP H 33 16.053 -10.225 -3.649 1.00 6.24 ATOM 2236 N MET H 34 16.911 -11.997 -2.481 1.00 7.22 ATOM 2238 CA METH 34 16.133 -11.752 -1.269 1.00 8.81 ATOM 2239 CB METH 34 15.113-12.860 -1.108 1.00 7.01 ATOM 2240 CG MET H 34 13.919-12.749 -2.056 1.00 10.07 ATOM 2241 SD METH 34 12.885-11.275 -1.844 1.00 17.49 ATOM 2242 CE MET H 34 11.928 -11.767 -0.412 1.00 17.44 ATOM 2243 C METH 34 17.094-11.681 -0.057 1.00 7.51 ATOM 2244 O METH 34 18.197-12.256 -0.107 1.00 10.32 ATOM 2245 N ASN H 35 16.736 -10.899 0.981 1.00 6.44 ATOM 2247 CA ASN H 35 17.586-10.755 2.175 1.00 4.54 ATOM 2248 CB ASN H 35 18.198 -9.339 2.317 1.00 5.78 ATOM 2249 CG ASN H 35 18.906 -8.804 1.078 1.00 3.57 ATOM 2250 OD1 ASN H 35 20.148 -8.700 1.016 1.00 2.44 ATOM 2251 ND2 ASN H 35 18.121 -8.476 0.102 1.00 2.00 ATOM 2254 C ASN H 35 16.737 -10.941 3.433 1.00 4.23 ATOM 2255 O ASN H 35 15.499 -10.824 3.380 1.00 2.00 ATOM 2256 N TRP H 36 17.404 -11.282 4.532 1.00 4.82 ATOM 2258 CA TRPH 36 16.755 -11.238 5.831 1.00 6.51 ATOM 2259 CB TRP H 36 16.888 -12.554 6.607 1.00 4.15 ATOM 2260 CG TRPH 36 15.911-13.575 6.121 1.00 6.17 WO 99/10379 PCT/GB98/02542 -245 ATOM 2261 CD2 TRP H 36 14.527 -13.755 6.513 1.00 5.59 ATOM 2262 CE2 TRP H 36 13.987 -14.743 5.672 1.00 7.68 ATOM 2263 CE3 TRP H 36 13.668 -13.180 7.489 1.00 3.55 ATOM 2264 CD1 TRPH 36 16.138-14.443 5.102 1.00 7.43 ATOM 2265 NEI TRPH 36 14.995-15.119 4.847 1.0011.31 ATOM 2267 CZ2 TRP H 36 12.650 -15.189 5.749 1.00 7.42 ATOM 2268 CZ3 TRP H 36 12.315 -13.631 7.564 1.00 2.61 ATOM 2269 CH2 TRP H 36 11.829-14.613 6.706 1.00 5.75 ATOM 2270 C TRP H 36 17.391 -10.102 6.614 1.00 3.69 ATOM 2271 O TRP H 36 18.617 -9.907 6.585 1.00 3.88 ATOM 2272 N VALH 37 16.565 -9.310 7.251 1.00 8.04 ATOM 2274 CA VAL H 37 17.074 -8.206 8.049 1.00 4.88 ATOM 2275 CB VALH 37 16.856 -6.854 7.314 1.00 7.93 ATOM 2276 CGI VALH 37 17.122 -5.671 8.277 1.00 5.70 ATOM 2277 CG2 VAL H 37 17.779 -6.772 6.078 1.00 4.88 ATOM 2278 C VALH 37 16.275 -8.201 9.356 1.00 7.96 ATOM 2279 0 VALH 37 15.062 -8.279 9.294 1.00 10.89 ATOM 2280 N ARG H 38 16.929 -8.083 10.499 1.00 4.79 ATOM 2282 CA ARG H 38 16.186 -8.134 11.784 1.00 6.19 ATOM 2283 CB ARG H 38 16.715 -9.294 12.691 1.00 2.00 ATOM 2284 CG ARG H 38 18.083 -9.070 13.402 1.00 5.85 ATOM 2285 CD ARG H 38 18.660 -10.356 14.068 1.00 7.03 ATOM 2286 NE ARG H 38 20.113 -10.243 14.278 1.00 5.02 ATOM 2288 CZ ARG H 38 20.880-11.237 14.678 1.00 7.94 ATOM 2289 NH1 ARG H 38 22.163 -11.027 14.921 1.00 8.02 ATOM 2292 NH2 ARG H 38 20.378 -12.448 14.813 1.00 10.78 ATOM 2295 C ARG H 38 16.224 -6.783 12.565 1.00 9.00 ATOM 2296 O ARG H 38 17.177 -5.984 12.474 1.00 7.20 ATOM 2297 N GLNH 39 15.193 -6.535 13.334 1.00 10.07 ATOM 2299 CA GLN H 39 15.146 -5.313 14.106 1.00 13.88 ATOM 2300 CB GLN H 39 13.914 -4.517 13.693 1.00 12.70 ATOM 2301 CG GLN H 39 13.835 -3.170 14.378 1.00 13.88 ATOM 2302 CD GLN H 39 12.562 -2.454 14.079 1.00 10.90 ATOM 2303 OEI GLN H 39 11.554 -3.054 13.637 1.00 14.02 ATOM 2304 NE2GLNH 39 12.580 -1.161 14.311 1.00 19.33 ATOM 2307 C GLN H 39 15.092 -5.640 15.634 1.00 17.21 ATOM 2308 O GLNH 39 14.153 -6.324 16.086 1.00 11.06 ATOM 2309 N SERH 40 16.117 -5.159 16.390 1.0020.54 ATOM 2311 CA SERH 40 16.190 -5.352 17.844 1.0025.32 ATOM 2312 CB SERH 40 17.407 -6.212 18.210 1.0024.24 ATOM 2313 OG SERH 40 18.567 -5.412 18.281 1.0026.93 ATOM 2315 C SERH 40 16.346 -3.997 18.533 1.0026.35 ATOM 2316 O SERH 40 16.983 -3.109 17.969 1.0027.60 ATOM 2317 N PROH 41 15.798 -3.822 19.781 1.0029.80 ATOM 2318 CD PROH 41 15.063 -4.844 20.562 0.5026.67 ATOM 2319 CA PRO H 41 15.899 -2.545 20.545 1.00 29.86 ATOM 2320 CB PRO H 41 15.210 -2.883 21.864 0.50 28.55 ATOM 2321 CG PROH 41 15.328 -4.371 21.952 0.5027.83 ATOM 2322 C PRO H 41 17.369 -2.074 20.736 1.00 33.07 ATOM 2323 O PRO H 41 17.754 -0.924 20.401 1.00 33.27 ATOM 2324 N ALA H 42 18.194 -2.987 21.203 1.00 34.06 ATOM 2326 CA ALA H 42 19.603 -2.677 21.457 1.00 37.51 ATOM 2327 CB ALA H 42 20.208 -3.808 22.297 1.00 37.30 ATOM 2328 C ALA H 42 20.447 -2.482 20.170 1.00 37.45 ATOM 2329 O ALA H 42 21.605 -2.039 20.248 1.00 38.47 ATOM 2330 N LYS H 43 19.881 -2.791 18.996 1.00 36.93 WO 99/10379 PCT/GB98/02542 -246 ATOM 2332 CA LYS H 43 20.694 -2.812 17.802 1.0035.11 ATOM 2333 CB LYS H 43 21.032 -4.263 17.457 1.00 36.81 ATOM 2334 CG LYS H 43 21.896 -4.979 18.496 1.00 40.66 ATOM 2335 CD LYS H 43 22.480 -6.299 17.956 1.0040.17 ATOM 2336 CE LYS H 43 21.507 -7.487 18.083 1.00 38.65 ATOM 2337 NZ LYS H 43 22.138 -8.774 17.647 1.00 34.06 ATOM 2341 C LYS H 43 20.086 -2.153 16.574 1.0032.32 ATOM 2342 O LYSH 43 20.742 -2.115 15.545 1.0032.74 ATOM 2343 N GLY H 44 18.883 -1.625 16.653 1.0028.07 ATOM 2345 CA GLYH 44 18.269 -1.095 15.433 1.0026.41 ATOM 2346 C GLY H 44 18.252 -2.177 14.336 1.0022.61 ATOM 2347 O GLY H 44 18.077 -3.382 14.667 1.00 21.36 ATOM 2348 N LEU H 45 18.484 -1.780 13.056 1.00 18.78 ATOM 2350 CA LEUH 45 18.439 -2.758 11.923 1.00 14.74 ATOM 2351 CB LEUH 45 17.995 -2.110 10.590 1.00 10.90 ATOM 2352 CG LEU H 45 16.506 -1.789 10.431 1.00 7.35 ATOM 2353 CDI LEUH 45 16.262 -1.110 9.115 1.00 8.68 ATOM 2354 CD2 LEU H 45 15.627 -3.031 10.533 1.00 4.89 ATOM 2355 C LEU H 45 19.759 -3.470 11.715 1.00 13.85 ATOM 2356 O LEU H 45 20.859 -2.873 11.722 1.00 11.97 ATOM 2357 N GLU H 46 19.676 -4.774 11.523 1.00 13.05 ATOM 2359 CA GLU H 46 20.884 -5.550 11.294 1.00 10.92 ATOM 2360 CB GLUH 46 21.280 -6.310 12.572 1.00 12.86 ATOM 2361 CG GLU H 46 22.748 -6.634 12.653 1.0021.14 ATOM 2362 CD GLU H 46 23.081 -7.707 13.669 1.00 24.52 ATOM 2363 OEI GLU H 46 22.443 -7.735 14.753 1.00 28.63 ATOM 2364 OE2 GLU H 46 23.996 -8.514 13.387 1.00 25.36 ATOM 2365 C GLUH 46 20.644 -6.543 10.145 1.00 9.90 ATOM 2366 O GLU H 46 19.712 -7.358 10.197 1.00 6.95 ATOM 2367 N TRPH 47 21.457 -6.432 9.110 1.00 7.54 ATOM 2369 CA TRP H 47 21.327 -7.309 7.968 1.00 7.90 ATOM 2370 CB TRP H 47 22.045 -6.698 6.731 1.00 10.76 ATOM 2371 CG TRP H 47 22.145 -7.629 5.553 1.00 5.45 ATOM 2372 CD2 TRP H 47 23.284 -8.459 5.230 1.00 3.79 ATOM 2373 CE2TRPH 47 22.977 -9.168 4.069 1.00 2.00 ATOM 2374 CE3 TRP H 47 24.546 -8.669 5.829 1.00 3.96 ATOM 2375 CDI TRP H 47 21.183 -7.863 4.590 1.00 4.22 ATOM 2376 NE1 TRP H 47 21.707 -8.793 3.707 1.00 5.25 ATOM 2378 CZ2 TRP H 47 23.875 -10.060 3.490 1.00 2.56 ATOM 2379 CZ3 TRP H 47 25.423 -9.560 5.251 1.00 2.00 ATOM 2380 CH2 TRP H 47 25.079 -10.232 4.094 1.00 2.00 ATOM 2381 C TRPH 47 21.908 -8.649 8.352 1.00 2.55 ATOM 2382 O TRPH 47 22.958 -8.730 8.976 1.00 5.06 ATOM 2383 N VAL H 48 21.209 -9.667 7.995 1.00 6.21 ATOM 2385 CA VALH 48 21.538-10.996 8.431 1.00 7.94 ATOM 2386 CB VALH 48 20.256-11.544 9.165 1.00 7.86 ATOM 2387 CGI VAL H 48 20.190 -13.054 9.168 1.00 10.48 ATOM 2388 CG2 VAL H 48 20.234 -10.992 10.603 1.00 4.08 ATOM 2389 C VAL H 48 22.041 -11.928 7.262 1.00 8.81 ATOM 2390 O VAL H 48 23.086 -12.617 7.396 1.00 5.89 ATOM 2391 N ALAH 49 21.334-11.913 6.123 1.00 6.18 ATOM 2393 CA ALA H 49 21.687 -12.816 5.031 1.00 4.66 ATOM 2394 CB ALA H 49 21.194 -14.210 5.349 1.00 2.00 ATOM 2395 C ALA H 49 21.046 -12.385 3.728 1.00 5.58 ATOM 2396 O ALA H 49 20.003 -11.745 3.740 1.00 7.99 ATOM 2397 N GLU H 50 21.696 -12.784 2.609 1.00 7.04 WO 99/10379 PCT/GB98/02542 -247 ATOM 2399 CA GLU H 50 21.163 -12.558 1.264 1.00 8.25 ATOM 2400 CB GLU H 50 21.979-11.510 0.501 1.00 9.60 ATOM 2401 CG GLU H 50 23.410-11.908 0.258 1.00 7.83 ATOM 2402 CD GLU H 50 24.060-11.041 -0.762 1.00 13.01 ATOM 2403 OEI GLU H 50 24.890-11.555 -1.523 1.00 9.53 ATOM 2404 OE2 GLU H 50 23.733 -9.831 -0.810 1.00 13.19 ATOM 2405 C GLU H 50 21.271 -13.869 0.479 1.00 6.87 ATOM 2406 O GLU H 50 22.100 -14.697 0.811 1.00 5.50 ATOM 2407 N ILEH 51 20.411 -14.037 -0.511 1.00 7.46 ATOM 2409 CA ILEH 51 20.504-15.187 -1.426 1.00 6.66 ATOM 2410 CB ILEH 51 19.517-16.301 -1.071 1.00 3.45 ATOM 2411 CG2 ILEH 51 18.070 -15.818 -1.217 1.00 9.97 ATOM 2412 CGI ILEH 51 19.780-17.539 -1.911 1.00 2.00 ATOM 2413 CD ILE H 51 18.845 -18.675 -1.563 1.00 2.00 ATOM 2414 C ILE H 51 20.238-14.704 -2.859 1.00 5.59 ATOM .2415 O ILEH 51 19.284-13.985 -3.134 1.00 5.07 ATOM 2416 N ARG H 52 21.096 -15.107 -3.756 1.00 6.35 ATOM 2418 CA ARG H 52 20.994 -14.629 -5.120 1.00 8.96 ATOM 2419 CB ARG H 52 22.408 -14.461 -5.694 1.00 5.72 ATOM 2420 CG ARG H 52 23.474 -14.344 -4.589 1.00 12.48 ATOM 2421 CD ARG H 52 24.048 -12.970 -4.373 1.00 13.83 ATOM 2422 NE ARG H 52 25.246 -12.780 -5.134 1.00 12.25 ATOM 2424 CZ ARG H 52 26.246-11.933 -4.828 1.00 12.96 ATOM 2425 NHI ARG H 52 27.255 -11.857 -5.635 1.00 11.49 ATOM 2428 NH2 ARG H 52 26.249 -11.156 -3.759 1.00 14.67 ATOM 2431 C ARG H 52 20.089 -15.503 -5.973 1.00 10.32 ATOM 2432 O ARG H 52 19.257-16.224 -5.438 1.00 8.96 ATOM 2433 N LEU H 52A 20.244 -15.437 -7.320 1.00 9.13 ATOM 2435 CA LEUH 52A 19.300-16.095 -8.199 1.00 9.35 ATOM 2436 CB LEU H 52A 19.204 -15.297 -9.499 1.00 8.23 ATOM 2437 CG LEUH 52A 19.031 -13.765 -9.341 1.00 4.43 ATOM 2438 CD1 LEU H 52A 19.048 -13.106 -10.712 1.00 9.87 ATOM 2439 CD2 LEU H 52A 17.727 -13.445 -8.645 1.00 4.72 ATOM 2440 C LEU H 52A 19.657 -17.540 -8.504 1.00 6.27 ATOM 2441 O LEU H 52A 20.750 -18.001 -8.220 1.00 6.95 ATOM 2442 N LYS H 52B 18.723 -18.250 -9.074 1.00 7.45 ATOM 2444 CA LYSH 52B 19.023 -19.580 -9.558 1.00 11.04 ATOM 2445 CB LYS H 52B 17.873 -20.081 -10.384 1.00 13.40 ATOM 2446 CG LYS H 52B 18.078-21.510-10.825 1.00 18.86 ATOM 2447 CD LYS H 52B 16.930-21.989 -11.679 1.0021.41 ATOM 2448 CE LYS H 52B 17.323 -23.278 -12.418 1.0027.85 ATOM 2449 NZ LYS H 52B 16.318 -23.616 -13.459 1.0034.07 ATOM 2453 C LYSH 52B 20.289-19.578-10.406 1.00 11.82 ATOM 2454 O LYS H 52B 21.181 -20.376 -10.179 1.00 10.65 ATOM 2455 N SERH 52C 20.369-18.635-11.381 1.00 10.14 ATOM 2457 CA SER H 52C 21.525 -18.526 -12.237 1.00 8.75 ATOM 2458 CB SERH 52C 21.282-17.520-13.358 1.00 11.63 ATOM 2459 OG SER H 52C 20.885 -16.286 -12.846 1.00 15.43 ATOM 2461 C SERH 52C 22.786-18.177-11.507 1.00 11.06 ATOM 2462 O SER H 52C 23.852 -18.244 -12.093 1.00 9.23 ATOM 2463 N ASN H 53 22.687 -17.797 -10.207 1.00 10.74 ATOM 2465 CA ASNH 53 23.890-17.552 -9.399 1.00 11.27 ATOM 2466 CB ASN H 53 23.664 -16.369 -8.474 1.00 10.94 ATOM 2467 CG ASN H 53 23.347 -15.139 -9.257 1.00 8.42 ATOM 2468 ODI ASN H 53 22.269 -14.573 -9.150 1.00 12.13 ATOM 2469 ND2 ASN H 53 24.281 -14.733 -10.056 1.00 10.17 WO 99/10379 PCT/GB98/02542 -248 ATOM 2472 C ASN H 53 24.200 -18.799 -8.559 1.00 10.33 ATOM 2473 O ASN H 53 25.123 -18.802 -7.711 1.00 9.92 ATOM 2474 N ASN H 54 23.433 -19.867 -8.841 1.00 10.20 ATOM 2476 CA ASN H 54 23.553 -21.171 -8.120 1.00 10.20 ATOM 2477 CB ASN H 54 25.018 -21.608 -7.987 1.00 6.42 ATOM 2478 CG ASN H 54 25.728 -21.672 -9.344 1.00 8.73 ATOM 2479 OD1 ASN H 54 25.259 -22.310 -10.276 1.00 8.04 ATOM 2480 ND2 ASN H 54 26.831 -20.992 -9.465 1.00 4.73 ATOM 2483 C ASN H 54 22.954-21.063 -6.718 1.00 11.89 ATOM 2484 O ASNH 54 23.310-21.844 -5.837 1.00 12.26 ATOM 2485 N TYRH 55 22.027-20.102 -6.536 1.00 9.38 ATOM 2487 CA TYRH 55 21.467-19.805 -5.191 1.00 8.46 ATOM 2488 CB TYRH 55 20.675 -20.998 -4.712 1.00 2.42 ATOM 2489 CG TYRH 55 19.506-21.296 -5.592 1.00 8.11 ATOM 2490 CD1 TYR H 55 19.493 -22.436 -6.421 1.00 9.49 ATOM 2491 CE1 TYRH 55 18.379-22.709 -7.234 1.00 12.87 ATOM 2492 CD2 TYRH 55 18.408 -20.468 -5.600 1.00 4.03 ATOM 2493 CE2TYRH 55 17.313 -20.726 -6.393 1.00 11.68 ATOM 2494 CZ TYRH 55 17.296-21.852 -7.220 1.00 15.91 ATOM 2495 OH TYRH 55 16.178 -22.098 -8.056 1.0020.99 ATOM 2497 C TYRH 55 22.591 -19.439 -4.184 1.00 8.90 ATOM 2498 O TYRH 55 22.558-19.848 -3.000 1.00 12.11 ATOM 2499 N ALA H 56 23.578 -18.631 -4.656 1.00 5.77 ATOM 2501 CA ALA H 56 24.694 -18.199 -3.833 1.00 7.06 ATOM 2502 CB ALA H 56 25.723 -17.516 -4.733 1.00 11.84 ATOM 2503 C ALAH 56 24.214-17.266 -2.667 1.00 7.10 ATOM 2504 O ALAH 56 23.170-16.606 -2.757 1.00 5.63 ATOM 2505 N THRH 57 24.963 -17.246 -1.571 1.00 7.85 ATOM 2507 CA THR H 57 24.500 -16.552 -0.372 1.00 6.03 ATOM 2508 CB THRH 57 23.968-17.571 0.680 1.00 4.33 ATOM 2509 OG1 THRH 57 25.027-18.488 1.036 1.00 3.89 ATOM 2511 CG2THRH 57 22.767-18.362 0.166 1.00 3.87 ATOM 2512 C THRH 57 25.616-15.821 0.286 1.00 4.64 ATOM 2513 O THR H 57 26.803 -16.086 0.030 1.00 7.15 ATOM 2514 N HIS H 58 25.259-14.857 1.133 1.00 5.83 ATOM 2516 CA HIS H 58 26.265 -14.223 2.005 1.00 2.00 ATOM 2517 CB HIS H 58 26.868 -12.919 1.470 1.00 4.50 ATOM 2518 CG HIS H 58 27.547 -13.109 0.164 1.00 4.63 ATOM 2519 CD2 HIS H 58 28.832 -13.271 -0.177 1.00 7.27 ATOM 2520 ND1 HIS H 58 26.850 -13.173 -0.991 1.00 5.48 ATOM 2522 CEI HIS H 58 27.613 -13.361 -2.013 1.00 8.70 ATOM 2523 NE2 HIS H 58 28.822 -13.418 -1.542 1.00 9.97 ATOM 2525 C HIS H 58 25.588 -13.987 3.334 1.00 2.00 ATOM 2526 O HIS H 58 24.363 -13.904 3.369 1.00 2.00 ATOM 2527 N TYRH 59 26.384-13.953 4.377 1.00 3.87 ATOM 2529 CA TYR H 59 25.875 -13.909 5.761 1.00 6.14 ATOM 2530 CB TYRH 59 26.152-15.253 6.442 1.00 4.65 ATOM 2531 CG TYRH 59 25.309-16.336 5.884 1.00 2.93 ATOM 2532 CD1 TYR H 59 25.788 -17.155 4.883 1.00 7.71 ATOM 2533 CE1 TYR H 59 24.973 -18.093 4.290 1.00 5.29 ATOM 2534 CD2TYRH 59 23.985 -16.488 6.289 1.00 4.20 ATOM 2535 CE2TYRH 59 23.184-17.418 5.699 1.00 5.04 ATOM 2536 CZ TYR H 59 23.705 -18.212 4.689 1.00 5.90 ATOM 2537 OH TYR H 59 22.942 -19.140 4.124 1.00 9.69 ATOM 2539 C TYRH 59 26.600-12.897 6.559 1.00 6.82 ATOM 2540 O TYRH 59 27.771 -12.697 6.337 1.00 7.72 WO 99/10379 PCT/GB98/02542 -249 ATOM 2541 N ALA H 60 25.925 -12.282 7.515 1.00 8.95 ATOM 2543 CA ALA H 60 26.639 -11.382 8.424 1.00 6.79 ATOM 2544 CB ALA H 60 25.661 -10.580 9.276 1.00 8.53 ATOM 2545 C ALA H 60 27.486 -12.224 9.322 1.00 10.22 ATOM 2546 O ALA H 60 27.095 -13.356 9.685 1.00 11.26 ATOM 2547 N ALAH 61 28.630-11.687 9.731 1.00 13.53 ATOM 2549 CA ALA H 61 29.557 -12.439 10.577 1.00 14.91 ATOM 2550 CB ALAH 61 30.778-11.575 10.917 1.00 14.40 ATOM 2551 C ALA H 61 28.899 -12.973 11.866 1.00 17.24 ATOM 2552 O ALA H 61 29.251 -14.049 12.335 1.00 21.67 ATOM 2553 N SERH 62 27.923 -12.257 12.408 1.00 18.88 ATOM 2555 CA SERH 62 27.304-12.651 13.691 1.0020.00 ATOM 2556 CB SER H 62 26.493 -11.485 14.211 1.00 16.39 ATOM 2557 OG SERH 62 25.625 -10.986 13.206 1.00 18.61 ATOM 2559 C SERH 62 26.378 -13.857 13.557 1.0021.12 ATOM 2560 O SERH 62 25.799-14.355 14.542 1.00 19.05 ATOM 2561 N VAL H 63 26.235 -14.324 12.350 1.00 18.08 ATOM 2563 CA VALH 63 25.239-15.311 12.066 1.00 17.68 ATOM 2564 CB VAL H 63 24.130 -14.543 11.334 1.00 18.65 ATOM 2565 CG1 VAL H 63 23.637 -15.237 10.092 1.00 16.99 ATOM 2566 CG2 VAL H 63 23.017 -14.228 12.333 1.00 12.88 ATOM 2567 C VAL H 63 25.838-16.474 11.274 1.00 15.76 ATOM 2568 0 VALH 63 25.290-17.566 11.214 1.00 14.97 ATOM 2569 N LYS H 64 27.015 -16.239 10.768 1.00 18.14 ATOM 2571 CA LYS H 64 27.688-17.213 9.966 1.0020.28 ATOM 2572 CB LYS H 64 29.059 -16.666 9.545 1.00 22.43 ATOM 2573 CG LYS H 64 29.150 -16.132 8.136 1.0020.56 ATOM 2574 CD LYSH 64 30.593 -15.735 7.835 1.0023.16 ATOM 2575 CE LYS H 64 30.751 -15.203 6.425 0.01 21.98 ATOM 2576 NZ LYS H 64 32.163 -14.833 6.129 0.01 23.60 ATOM 2580 C LYS H 64 27.858 -18.496 10.756 1.00 18.78 ATOM 2581 O LYS H 64 28.225 -18.458 11.926 1.0020.26 ATOM 2582 N GLY H 65 27.565 -19.618 10.110 1.00 17.68 ATOM 2584 CA GLY H 65 27.700 -20.919 10.761 1.00 16.07 ATOM 2585 C GLY H 65 26.476 -21.353 11.581 1.00 14.30 ATOM 2586 O GLYH 65 26.364-22.517 11.931 1.00 14.97 ATOM 2587 N ARG H 66 25.553 -20.432 11.876 1.00 14.24 ATOM 2589 CA ARG H 66 24.336 -20.780 12.624 1.00 10.28 ATOM 2590 CB ARG H 66 24.261 -19.924 13.862 1.00 7.89 ATOM 2591 CG ARG H 66 25.503 -20.000 14.713 1.00 7.93 ATOM 2592 CD ARG H 66 25.673 -18.695 15.483 1.00 14.73 ATOM 2593 NE ARG H 66 24.525 -18.448 16.272 1.00 17.33 ATOM 2595 CZ ARG H 66 23.913 -17.292 16.390 1.00 17.22 ATOM 2596 NH I ARG H 66 22.879 -17.258 17.140 1.00 18.44 ATOM 2599 NH2ARGH 66 24.319-16.184 15.800 1.00 15.39 ATOM 2602 C ARG H 66 23.090-20.589 11.803 1.00 9.54 ATOM 2603 O ARGH 66 22.071 -21.275 12.011 1.00 11.68 ATOM 2604 N PHEH 67 23.106-19.623 10.884 1.00 9.08 ATOM 2606 CA PHE H 67 21.905 -19.393 10.055 1.00 8.27 ATOM 2607 CB PHE H 67 21.485 -17.896 10.062 1.00 14.66 ATOM 2608 CG PHE H 67 20.955 -17.333 11.365 1.00 11.27 ATOM 2609 CDI PHEH 67 20.951 -18.096 12.552 1.00 16.10 ATOM 2610 CD2 PHE H 67 20.441 -16.043 11.410 1.00 12.21 ATOM 2611 CEI PHEH 67 20.452-17.567 13.739 1.00 15.15 ATOM 2612 CE2 PHE H 67 19.943 -15.515 12.603 1.00 16.05 ATOM 2613 CZ PHE H 67 19.952 -16.276 13.758 1.00 14.19 WO 99/10379 PCT/GB98/02542 -250 ATOM 2614 C PHEH 67 22.151 -19.809 8.590 1.00 8.04 ATOM 2615 O PHEH 67 23.308-19.737 8.107 1.00 7.14 ATOM 2616 N THRH 68 21.069-20.222 7.902 1.00 5.55 ATOM 2618 CA THRH 68 21.135 -20.635 6.488 1.00 6.31 ATOM 2619 CB THR H 68 21.138 -22.179 6.392 1.00 10.66 ATOM 2620 OGI THR H 68 22.268 -22.681 7.120 1.00 8.86 ATOM 2622 CG2 THRH 68 21.158 -22.667 4.935 1.00 10.19 ATOM 2623 C THRH 68 19.909-20.118 5.735 1.00 6.07 ATOM 2624 O THRH 68 18.761 -20.448 6.076 1.00 9.45 ATOM 2625 N ILE H 69 20.134 -19.267 4.742 1.00 4.87 ATOM 2627 CA ILE H 69 19.048 -18.766 3.956 1.00 2.00 ATOM 2628 CB ILE H 69 19.312 -17.255 3.525 1.00 6.99 ATOM 2629 CG2 ILEH 69 20.551 -17.113 2.660 1.00 7.03 ATOM 2630 CGI ILE H 69 18.099 -16.665 2.797 1.00 2.00 ATOM 2631 CD ILEH 69 18.333 -15.229 2.387 1.00 2.00 ATOM 2632 C ILEH 69 18.896-19.677 2.718 1.00 2.51 ATOM 2633 O ILE H 69 19.874 -20.221 2.257 1.00 2.38 ATOM 2634 N SER H 70 17.690 -19.872 2.253 1.00 2.57 ATOM 2636 CA SERH 70 17.478-20.679 1.081 1.00 6.14 ATOM 2637 CB SERH 70 17.375 -22.176 1.473 1.00 9.52 ATOM 2638 OG SERH 70 16.243 -22.479 2.291 1.00 10.39 ATOM 2640 C SERH 70 16.224 -20.206 0.384 1.00 6.48 ATOM 2641 O SERH 70 15.483 -19.433 0.956 1.00 7.77 ATOM 2642 N ARG H 71 15.977 -20.635 -0.859 1.00 7.82 ATOM 2644 CA ARG H 71 14.771 -20.200 -1.545 1.00 8.16 ATOM 2645 CB ARG H 71 15.013 -18.926 -2.433 1.00 10.92 ATOM 2646 CG ARG H 71 16.003 -19.089 -3.610 1.00 8.76 ATOM 2647 CD ARG H 71 16.351 -17.736 -4.291 1.00 4.61 ATOM 2648 NE ARG H 71 15.173 -17.037 -4.839 1.00 7.09 ATOM 2650 CZ ARG H 71 15.201 -15.734 -5.185 1.00 7.29 ATOM 2651 NH1 ARG H 71 14.129 -15.130 -5.657 1.00 8.76 ATOM 2654 NH2ARG H 71 16.294-15.048 -5.020 1.00 3.13 ATOM 2657 C ARG H 71 14.170 -21.289 -2.385 1.00 9.04 ATOM 2658 O ARG H 71 14.832 -22.200 -2.814 1.00 11.10 ATOM 2659 N ASP H 72 12.920 -21.167 -2.619 1.00 8.40 ATOM 2661 CA ASP H 72 12.275 -22.064 -3.477 1.00 13.86 ATOM 2662 CB ASP H 72 11.461 -23.048 -2.660 1.00 18.00 ATOM 2663 CG ASP H 72 10.873 -24.134 -3.531 1.00 22.29 ATOM 2664 OD1 ASP H 72 9.993 -23.818 -4.333 1.00 18.82 ATOM 2665 OD2 ASP H 72 11.286 -25.303 -3.392 1.00 29.08 ATOM 2666 C ASP H 72 11.402-21.244 -4.397 1.00 12.87 ATOM 2667 O ASP H 72 10.324-20.782 -4.036 1.00 11.56 ATOM 2668 N ASP H 73 11.894-21.045 -5.587 1.00 14.62 ATOM 2670 CA ASP H 73 11.183 -20.241 -6.506 1.00 12.47 ATOM 2671 CB ASP H 73 12.023 -19.903 -7.750 1.00 14.32 ATOM 2672 CG ASP H 73 13.316-19.152 -7.394 1.00 12.44 ATOM 2673 ODI ASP H 73 13.315 -18.402 -6.404 1.00 13.98 ATOM 2674 OD2 ASP H 73 14.333 -19.334 -8.080 1.00 14.38 ATOM 2675 C ASP H 73 9.918 -20.906 -6.865 1.00 15.39 ATOM 2676 O ASPH 73 8.966-20.160 -7.111 1.00 17.19 ATOM 2677 N SER H 74 9.842 -22.307 -6.828 1.00 16.30 ATOM 2679 CA SERH 74 8.521 -22.992 -7.159 1.00 17.45 ATOM 2680 CB SERH 74 8.491 -24.605 -7.038 1.00 15.19 ATOM 2681 OG SERH 74 9.303 -25.285 -6.039 1.00 2.00 ATOM 2683 C SERH 74 7.416-22.405 -6.303 1.00 19.15 ATOM 2684 O SER H 74 6.283 -22.217 -6.761 1.00 16.07 WO 99/10379 PCT/GB98/02542 -251 ATOM 2685 N LYS H 75 7.806 -22.025 -5.060 1.00 20.59 ATOM 2687 CA LYS H 75 6.859 -21.536 -4.058 1.0022.07 ATOM 2688 CB LYS H 75 7.170 -22.240 -2.730 1.0022.73 ATOM 2689 CG LYS H 75 7.169 -23.755 -2.843 1.0030.86 ATOM 2690 CD LYS H 75 8.092 -24.404 -1.815 1.00 34.56 ATOM 2691 CE LYS H 75 7.990 -25.915 -1.886 1.00 36.81 ATOM 2692 NZ LYS H 75 6.612 -26.394 -1.547 1.00 38.63 ATOM 2696 C LYS H 75 6.895 -20.023 -3.852 1.00 21.01 ATOM 2697 O LYS H 75 6.150 -19.485 -3.012 1.00 18.31 ATOM 2698 N SERH 76 7.738-19.325 -4.592 1.00 18.64 ATOM 2700 CA SER H 76 7.840 -17.868 -4.412 1.00 16.65 ATOM 2701 CB SERH 76 6.519 -17.188 -4.729 1.00 18.03 ATOM 2702 OG SER H 76 6.400 -16.854 -6.090 1.0023.00 ATOM 2704 C SERH 76 8.150-17.583 -2.961 1.00 15.08 ATOM 2705 O SERH 76 7.560-16.691 -2.397 1.00 13.71 ATOM 2706 N SERH 77 9.072-18.354 -2.371 1.00 12.40 ATOM 2708 CA SERH 77 9.328-18.216 -0.955 1.00 11.32 ATOM 2709 CB SER H 77 8.642 -19.362 -0.220 1.00 5.62 ATOM 2710 OG SERH 77 7.217-19.321 -0.359 1.00 11.83 ATOM 2712 C SERH 77 10.798-18.213 -0.655 1.00 11.23 ATOM 2713 O SERH 77 11.586-18.831 -1.383 1.00 10.52 ATOM 2714 N VALH 78 11.174-17.444 0.375 1.00 11.36 ATOM 2716 CA VAL H 78 12.553 -17.452 0.903 1.00 9.82 ATOM 2717 CB VAL H 78 13.271 -16.054 0.775 1.00 2.05 ATOM 2718 CGI VALH 78 12.610-15.007 1.602 1.00 8.95 ATOM 2719 CG2VALH 78 14.718-16.159 1.131 1.00 6.47 ATOM 2720 C VAL H 78 12.442 -17.927 2.373 1.00 10.77 ATOM 2721 0 VALH 78 11.348-17.873 2.946 1.00 10.22 ATOM 2722 N TYRH 79 13.512-18.464 2.944 1.00 9.85 ATOM 2724 CA TYRH 79 13.408-19.077 4.283 1.00 11.42 ATOM 2725 CB TYRH 79 13.281 -20.600 4.156 1.00 8.95 ATOM 2726 CG TYRH 79 12.220-21.110 3.202 1.00 9.83 ATOM 2727 CD1 TYRH 79 10.886-21.256 3.590 1.00 13.08 ATOM 2728 CE1 TYRH 79 9.933 -21.792 2.727 1.00 13.31 ATOM 2729 CD2 TYRH 79 12.565 -21.505 1.916 1.00 16.54 ATOM 2730 CE2 TYR H 79 11.642 -22.044 1.053 1.00 13.14 ATOM 2731 CZ TYR H 79 10.327 -22.200 1.458 1.00 15.87 ATOM 2732 OH TYRH 79 9.440 -22.907 0.647 1.0021.63 ATOM 2734 C TYRH 79 14.656 -18.799 5.072 1.00 8.87 ATOM 2735 O TYRH 79 15.682-18.508 4.482 1.00 7.96 ATOM 2736 N LEU H 80 14.563 -18.863 6.414 1.00 7.68 ATOM 2738 CA LEUH 80 15.756-18.731 7.274 1.00 6.13 ATOM 2739 CB LEU H 80 15.865 -17.319 7.926 1.00 3.75 ATOM 2740 CG LEU H 80 17.161 -17.024 8.774 1.00 5.89 ATOM 2741 CDI LEU H 80 18.360 -16.785 7.857 1.00 7.66 ATOM 2742 CD2 LEU H 80 16.965 -15.789 9.665 1.00 7.64 ATOM 2743 C LEUH 80 15.717-19.812 8.384 1.00 6.11 ATOM 2744 O LEU H 80 14.834 -19.823 9.212 1.00 10.81 ATOM 2745 N GLNH 81 16.636-20.703 8.314 1.00 9.34 ATOM 2747 CA GLN H 81 16.809 -21.750 9.279 1.00 7.35 ATOM 2748 CB GLN H 81 17.433 -22.959 8.585 1.00 10.80 ATOM 2749 CG GLN H 81 17.864 -24.103 9.486 1.00 7.67 ATOM 2750 CD GLN H 81 16.700 -24.584 10.255 1.00 12.30 ATOM 2751 OE1 GLN H 81 15.667 -24.853 9.682 1.00 9.50 ATOM 2752 NE2 GLN H 81 16.834 -24.650 11.577 1.00 14.89 ATOM 2755 C GLN H 81 17.760 -21.249 10.279 1.00 7.63 WO 99/10379 PCT/GB98/02542 -252 ATOM 2756 0 GLN H 81 18.905 -20.980 9.946 1.00 6.37 ATOM 2757 N METH 82 17.330-21.109 11.519 1.00 8.18 ATOM 2759 CA METH 82 18.239-20.590 12.561 1.00 8.53 ATOM 2760 CB METH 82 17.585 -19.400 13.268 1.00 11.01 ATOM 2761 CG METH 82 17.055 -18.374 12.312 1.00 12.29 ATOM 2762 SD METH 82 15.951 -17.219 13.067 1.00 13.74 ATOM 2763 CE MET H 82 14.487 -18.141 12.822 1.00 14.37 ATOM 2764 C MET H 82 18.515 -21.680 13.589 1.00 8.43 ATOM 2765 O MET H 82 17.572-22.280 14.081 1.00 5.71 ATOM 2766 N ASN H 82A 19.781 -21.872 13.891 1.00 8.95 ATOM 2768 CA ASN H 82A 20.234 -22.884 14.806 1.00 11.83 ATOM 2769 CB ASN H 82A 21.152 -23.876 14.109 1.00 14.31 ATOM 2770 CG ASN H 82A 20.457 -24.638 13.025 1.00 14.14 ATOM 2771 ODI ASN H 82A 19.230-24.729 13.011 1.00 20.53 ATOM 2772 ND2 ASN H 82A 21.227 -25.160 12.091 1.00 19.33 ATOM 2775 C ASN H 82A 21.065 -22.233 15.867 1.00 14.07 ATOM 2776 O ASN H 82A 21.572 -21.134 15.663 1.00 12.90 ATOM 2777 N ASN H 82B 21.234 -22.937 16.970 1.00 13.76 ATOM 2779 CA ASN H 82B 22.093 -22.461 18.068 1.00 17.95 ATOM 2780 CB ASN H 82B 23.592 -22.660 17.695 1.00 20.73 ATOM 2781 CG ASN H 82B 23.893 -24.013 16.977 1.0029.83 ATOM 2782 OD1 ASN H 82B 23.763 -25.120 17.540 1.00 32.41 ATOM 2783 ND2ASNH 82B 24.310-23.938 15.711 1.0033.10 ATOM 2786 C ASN H 82B 21.755 -20.982 18.401 1.00 15.91 ATOM 2787 O ASNH 82B 22.626-20.117 18.539 1.00 12.49 ATOM 2788 N LEU H 82C 20.438 -20.717 18.487 1.00 14.84 ATOM 2790 CA LEU H 82C 19.930 -19.385 18.761 1.00 13.25 ATOM 2791 CB LEU H 82C 18.398 -19.413 18.672 1.00 7.42 ATOM 2792 CG LEU H 82C 17.778 -19.383 17.253 1.00 7.73 ATOM 2793 CDI LEU H 82C 16.299 -19.736 17.262 1.00 4.66 ATOM 2794 CD2 LEU H 82C 17.929 -18.000 16.670 1.00 2.94 ATOM 2795 C LEUH 82C 20.463-18.841 20.118 1.00 16.15 ATOM 2796 O LEU H 82C 20.746 -19.599 21.059 1.00 17.22 ATOM 2797 N ARG H 83 20.662 -17.536 20.166 1.00 16.23 ATOM 2799 CA ARG H 83 21.172 -16.854 21.323 1.00 16.47 ATOM 2800 CB ARG H 83 22.493 -16.228 20.989 1.00 17.57 ATOM 2801 CG ARG H 83 23.517 -17.164 20.447 1.0023.38 ATOM 2802 CD ARG H 83 24.663 -16.327 19.937 1.0029.30 ATOM 2803 NE ARGH 83 25.731 -17.110 19.366 1.0030.53 ATOM 2805 CZ ARG H 83 26.727 -16.556 18.689 1.00 33.66 ATOM 2806 NHI ARG H 83 27.699 -17.323 18.213 1.00 37.56 ATOM 2809 NH2 ARG H 83 26.754 -15.227 18.483 1.00 35.33 ATOM 2812 C ARG H 83 20.209 -15.733 21.680 1.00 17.82 ATOM 2813 O ARG H 83 19.500 -15.237 20.805 1.00 19.55 ATOM 2814 N ALA H 84 20.198 -15.271 22.920 1.00 14.91 ATOM 2816 CA ALA H 84 19.259 -14.191 23.263 1.00 16.48 ATOM 2817 CB ALA H 84 19.353 -13.846 24.737 1.00 15.35 ATOM 2818 C ALA H 84 19.489 -12.925 22.398 1.00 14.44 ATOM 2819 O ALA H 84 18.540-12.166 22.124 1.00 16.17 ATOM 2820 N ALA H 85 20.743 -12.729 21.953 1.00 15.72 ATOM 2822 CA ALA H 85 21.087-11.588 21.103 1.00 15.91 ATOM 2823 CB ALAH 85 22.610-11.473 20.964 1.00 11.61 ATOM 2824 C ALA H 85 20.428 -11.685 19.703 1.00 15.42 ATOM 2825 O ALA H 85 20.460 -10.694 18.938 1.00 14.28 ATOM 2826 N ASP H 86 19.859 -12.870 19.362 1.00 12.78 ATOM 2828 CA ASP H 86 19.166 -13.055 18.066 1.00 10.42 WO 99/10379 PCT/GB98/02542 -253 ATOM 2829 CB ASP H 86 19.191 -14.501 17.595 1.00 4.96 ATOM 2830 CG ASP H 86 20.581 -15.025 17.414 1.00 10.01 ATOM 2831 ODI ASP H 86 20.814-16.181 17.786 1.00 12.26 ATOM 2832 OD2 ASP H 86 21.440 -14.291 16.916 1.00 8.11 ATOM 2833 C ASP H 86 17.735 -12.629 18.149 1.00 8.78 ATOM 2834 O ASP H 86 17.003 -12.673 17.172 1.00 12.52 ATOM 2835 N THRH 87 17.316-12.239 19.320 1.00 8.30 ATOM 2837 CA THRH 87 15.948-11.788 19.506 1.00 8.21 ATOM 2838 CB THRH 87 15.713-11.445 21.041 1.00 7.33 ATOM 2839 OGI THRH 87 15.904-12.634 21.815 1.00 6.98 ATOM 2841 CG2 THR H 87 14.316 -10.935 21.301 1.00 5.67 ATOM 2842 C THR H 87 15.688 -10.568 18.601 1.00 9.42 ATOM 2843 O THRH 87 16.564 -9.721 18.445 1.00 13.23 ATOM 2844 N GLY H 88 14.534 -10.520 17.972 1.00 7.71 ATOM 2846 CA GLY H 88 14.200 -9.359 17.178 1.00 9.10 ATOM 2847 C GLYH 88 13.112 -9.674 16.231 1.00 9.84 ATOM 2848 O GLY H 88 12.640 -10.813 16.227 1.00 7.86 ATOM 2849 N ILEH 89 12.641 -8.653 15.476 1.00 9.11 ATOM 2851 CA ILEH 89 11.638 -8.868 14.444 1.00 10.31 ATOM 2852 CB ILE H 89 10.773 -7.624 14.277 1.00 11.02 ATOM 2853 CG2 ILE H 89 9.706 -7.876 13.226 1.00 10.51 ATOM 2854 CG1 ILE H 89 10.139 -7.299 15.641 1.00 11.28 ATOM 2855 CD ILEH 89 9.326 -6.014 15.674 1.00 17.09 ATOM 2856 C ILEH 89 12.393 -9.160 13.141 1.00 11.03 ATOM 2857 O ILEH 89 13.338 -8.436 12.810 1.00 11.03 ATOM 2858 N TYRH 90 12.054-10.278 12.480 1.00 11.24 ATOM 2860 CA TYR H 90 12.766 -10.682 11.279 1.00 9.58 ATOM 2861 CB TYRH 90 13.153-12.144 11.352 1.00 4.73 ATOM 2862 CG TYRH 90 14.367-12.437 12.228 1.00 4.17 ATOM 2863 CD1 TYRH 90 14.304-12.317 13.632 1.00 2.00 ATOM 2864 CE1 TYRH 90 15.398-12.607 14.428 1.00 2.00 ATOM 2865 CD2TYRH 90 15.562-12.865 11.673 1.00 2.40 ATOM 2866 CE2TYRH 90 16.660-13.156 12.473 1.00 2.17 ATOM 2867 CZ TYRH 90 16.559-13.011 13.862 1.00 2.00 ATOM 2868 OH TYRH 90 17.670-13.217 14.659 1.00 2.45 ATOM 2870 C TYRH 90 11.941 -10.411 10.053 1.00 9.22 ATOM 2871 O TYRH 90 10.768-10.839 9.955 1.00 12.19 ATOM 2872 N TYRH 91 12.555 -9.661 9.125 1.00 8.92 ATOM 2874 CA TYRH 91 11.882 -9.261 7.869 1.00 6.94 ATOM 2875 CB TYRH 91 11.971 -7.724 7.693 1.00 8.51 ATOM 2876 CG TYRH 91 11.501 -6.909 8.859 1.00 7.13 ATOM 2877 CDI TYRH 91 10.187 -6.477 8.923 1.00 6.14 ATOM 2878 CE1 TYRH 91 9.726 -5.715 9.997 1.00 7.31 ATOM 2879 CD2 TYR H 91 12.367 -6.566 9.890 1.00 4.90 ATOM 2880 CE2TYRH 91 11.904 -5.806 10.978 1.00 8.04 ATOM 2881 CZ TYRH 91 10.578 -5.389 11.017 1.00 5.99 ATOM 2882 OH TYRH 91 10.097 -4.640 12.115 1.00 13.80 ATOM 2884 C TYR H 91 12.596 -9.868 6.640 1.00 5.68 ATOM 2885 O TYRH 91 13.819 -9.926 6.618 1.00 10.68 ATOM 2886 N CYS H 92 11.858-10.361 5.661 1.00 5.92 ATOM 2888 CA CYS H 92 12.499 -10.597 4.354 1.00 9.62 ATOM 2889 CB CYS H 92 11.868-11.756 3.624 1.00 8.20 ATOM 2890 SG CYS H 92 10.125-11.557 3.662 1.00 16.35 ATOM 2891 C CYS H 92 12.263 -9.318 3.528 1.00 7.60 ATOM 2892 O CYS H 92 11.176 -8.703 3.579 1.00 8.00 ATOM 2893 N THRH 93 13.236 -8.917 2.785 1.00 8.87 WO 99/10379 PCT/GB98/02542 -254 ATOM 2895 CA THRH 93 13.120 -7.666 2.031 1.00 9.75 ATOM 2896 CB THRH 93 13.581 -6.438 2.904 1.00 7.13 ATOM 2897 OG1 THRH 93 13.889 -5.309 2.059 1.00 8.11 ATOM 2899 CG2 THRH 93 14.789 -6.775 3.729 1.00 6.38 ATOM 2900 C THRH 93 13.983 -7.740 0.786 1.00 9.01 ATOM 2901 O THRH 93 15.024 -8.385 0.836 1.00 8.92 ATOM 2902 N GLY H 94 13.559 -7.104 -0.319 1.00 8.19 ATOM 2904 CA GLY H 94 14.395 -7.122 -1.486 1.00 9.97 ATOM 2905 C GLY H 94 13.962 -6.132 -2.539 1.00 11.34 ATOM 2906 O GLY H 94 13.054 -5.370 -2.318 1.00 8.22 ATOM 2907 N VAL H 95 14.679 -6.169 -3.673 1.00 13.48 ATOM 2909 CA VAL H 95 14.454 -5.327 -4.858 1.00 10.59 ATOM 2910 CB VAL H 95 13.009 -5.252 -5.284 1.00 9.92 ATOM 2911 CGI VAL H 95 12.943 -4.469 -6.574 1.00 12.93 ATOM 2912 CG2 VAL H 95 12.412 -6.635 -5.491 1.00 12.57 ATOM 2913 C VALH 95 14.985 -3.907 -4.740 1.00 12.91 ATOM 2914 0 VAL H 95 14.407 -3.047 -4.075 1.00 16.60 ATOM 2915 N GLY H 96 16.113 -3.695 -5.364 1.00 14.72 ATOM 2917 CA GLY H 96 16.722 -2.351 -5.505 1.00 17.50 ATOM 2918 C GLYH 96 16.912 -1.389 -4.282 1.00 15.41 ATOM 2919 O GLY H 96 16.467 -0.233 -4.348 1.00 16.20 ATOM 2920 N GLN H 97 17.515 -1.782 -3.162 1.00 13.46 ATOM 2922 CA GLN H 97 17.931 -3.133 -2.860 1.00 13.51 ATOM 2923 CB GLNH 97 19.415 -3.173 -2.470 1.00 11.95 ATOM 2924 CG GLN H 97 20.392 -3.138 -3.645 1.00 15.05 ATOM 2925 CD GLN H 97 20.369 -1.859 -4.476 1.00 16.43 ATOM 2926 OEI GLN H 97 20.832 -0.809 -4.044 1.00 17.08 ATOM 2927 NE2 GLN H 97 19.846 -1.954 -5.688 1.00 18.31 ATOM 2930 C GLNH 97 17.061 -3.628 -1.680 1.00 10.81 ATOM 2931 O GLNH 97 17.109 -4.795 -1.297 1.00 8.86 ATOM 2932 N PHEH 98 16.237 -2.728 -1.153 1.00 8.60 ATOM 2934 CA PHE H 98 15.365 -3.030 -0.021 1.00 8.66 ATOM 2935 CB PHEH 98 16.024 -2.558 1.275 1.00 11.54 ATOM 2936 CG PHE H 98 17.333 -3.213 1.620 1.00 9.16 ATOM 2937 CDI PHEH 98 17.356 -4.439 2.271 1.00 6.51 ATOM 2938 CD2 PHE H 98 18.544 -2.603 1.305 1.00 9.14 ATOM 2939 CE1 PHE H 98 18.564 -5.059 2.603 1.00 9.69 ATOM 2940 CE2 PHEH 98 19.744 -3.211 1.639 1.00 8.35 ATOM 2941 CZ PHE H 98 19.759 -4.454 2.296 1.00 6.22 ATOM 2942 C PHEH 98 14.056 -2.275 -0.180 1.00 10.16 ATOM 2943 O PHEH 98 13.588 -1.638 0.747 1.00 11.80 ATOM 2944 N ALA H 101 13.468 -2.339 -1.351 1.00 9.29 ATOM 2946 CA ALA H 101 12.252 -1.628 -1.609 1.00 8.04 ATOM 2947 CB ALAH 101 11.995 -1.543 -3.099 1.00 6.69 ATOM 2948 C ALAH 101 11.071 -2.292 -0.957 1.00 11.49 ATOM 2949 O ALAH 101 10.138 -1.589 -0.533 1.00 11.63 ATOM 2950 N TYRH 102 11.105 -3.644 -0.910 1.00 8.89 ATOM 2952 CA TYRH 102 9.998 -4.423 -0.366 1.00 13.48 ATOM 2953 CB TYRH 102 9.584 -5.528 -1.335 1.00 17.64 ATOM 2954 CG TYR H 102 9.293 -5.047 -2.725 1.00 19.49 ATOM 2955 CD1 TYR H 102 8.791 -3.766 -2.940 1.00 19.65 ATOM 2956 CE1 TYR H 102 8.480 -3.313 -4.208 1.00 19.68 ATOM 2957 CD2TYRH 102 9.490 -5.879 -3.831 1.0021.83 ATOM 2958 CE2TYRH 102 9.178 -5.422 -5.110 1.0024.66 ATOM 2959 CZ TYRH 102 8.667 -4.140 -5.282 1.0021.57 ATOM 2960 OH TYR H 102 8.253 -3.720 -6.536 1.00 29.25 WO 99/10379 PCT/GB98/02542 -255 ATOM 2962 C TYRH 102 10.402 -5.063 0.928 1.00 10.63 ATOM 2963 O TYR H 102 11.504 -5.604 1.031 1.00 10.52 ATOM 2964 N TRPH 103 9.509 -4.971 1.883 1.00 12.90 ATOM 2966 CA TRP H 103 9.710 -5.489 3.242 1.00 12.06 ATOM 2967 CB TRP H 103 9.957 -4.323 4.251 1.00 10.97 ATOM 2968 CG TRPH 103 11.277 -3.615 4.121 1.00 7.64 ATOM 2969 CD2 TRP H 103 12.428 -3.716 5.024 1.00 7.34 ATOM 2970 CE2 TRP H 103 13.445 -2.949 4.472 1.00 2.00 ATOM 2971 CE3 TRP H 103 12.677 -4.386 6.241 1.00 2.00 ATOM 2972 CD1 TRP H 103 11.664 -2.792 3.104 1.00 2.00 ATOM 2973 NEl TRP H 103 12.945 -2.407 3.329 1.00 5.49 ATOM 2975 CZ2 TRP H 103 14.706 -2.828 5.070 1.00 6.14 ATOM 2976 CZ3 TRP H 103 13.905 -4.272 6.837 1.00 4.72 ATOM 2977 CH2 TRP H 103 14.916 -3.504 6.262 1.00 4.93 ATOM 2978 C TRP H 103 8.426 -6.189 3.650 1.00 10.58 ATOM 2979 O TRPH 103 7.324 -5.684 3.357 1.00 12.28 ATOM 2980 N GLYH 104 8.524 -7.363 4.264 1.00 9.92 ATOM 2982 CA GLY H 104 7.304 -7.969 4.775 1.00 8.86 ATOM 2983 C GLY H 104 6.887 -7.282 6.081 1.00 11.03 ATOM 2984 O GLY H 104 7.519 -6.295 6.494 1.00 7.62 ATOM 2985 N GLNH 105 5.863 -7.817 6.742 1.00 14.11 ATOM 2987 CA GLN H 105 5.373 -7.251 8.007 1.00 13.52 ATOM 2988 CB GLN H 105 3.904 -7.694 8.265 1.00 16.08 ATOM 2989 CG GLN H 105 3.722 -9.067 8.895 1.00 16.34 ATOM 2990 CD GLN H 105 4.141 -10.239 8.024 1.00 17.73 ATOM 2991 OEI GLN H 105 4.224 -10.145 6.813 1.0021.14 ATOM 2992 NE2 GLN H 105 4.400 -11.364 8.646 1.00 22.59 ATOM 2995 C GLN H 105 6.276 -7.602 9.188 1.00 13.99 ATOM 2996 O GLN H 105 6.240 -6.925 10.216 1.00 12.82 ATOM 2997 N GLYH 106 7.111 -8.648 9.017 1.00 13.67 ATOM 2999 CA GLY H 106 8.029 -9.065 10.056 1.00 11.11 ATOM 3000 C GLY H 106 7.439-10.154 10.931 1.00 12.32 ATOM 3001 O GLY H 106 6.213 -10.270 11.084 1.00 11.02 ATOM 3002 N THRH 107 8.301 -10.977 11.484 1.00 14.65 ATOM 3004 CA THRH 107 7.855 -12.055 12.387 1.00 12.73 ATOM 3005 CB THRH 107 7.902-13.416 11.638 1.00 10.15 ATOM 3006 OG1 THR H 107 7.382-14.453 12.483 1.00 15.55 ATOM 3008 CG2 THRH 107 9.304 -13.766 11.191 1.00 4.69 ATOM 3009 C THRH 107 8.745-12.027 13.618 1.00 10.17 ATOM 3010 O THRH 107 9.944-11.924 13.479 1.00 10.87 ATOM 3011 N THRH 108 8.179-12.063 14.843 1.00 12.24 ATOM 3013 CA THR H 108 9.039 -11.937 16.025 1.00 10.94 ATOM 3014 CB THR H 108 8.360 -11.094 17.205 1.00 12.32 ATOM 3015 OGI THRH 108 9.224-10.934 18.347 1.00 13.78 ATOM 3017 CG2 THR H 108 7.088 -11.693 17.677 1.00 15.73 ATOM 3018 C THRH 108 9.605 -13.274 16.492 1.00 9.14 ATOM 3019 O THRH 108 8.933 -14.316 16.539 1.00 6.78 ATOM 3020 N VAL H 109 10.865 -13.225 16.754 1.00 8.85 ATOM 3022 CA VAL H 109 11.605 -14.332 17.261 1.00 9.39 ATOM 3023 CB VAL H 109 12.788-14.662 16.322 1.00 11.58 ATOM 3024 CG1 VAL H 109 13.739 -15.639 16.980 1.00 5.51 ATOM 3025 CG2 VAL H 109 12.268 -15.232 14.986 1.00 10.69 ATOM 3026 C VALH 109 12.174-13.883 18.589 1.00 12.15 ATOM 3027 O VAL H 109 12.926 -12.926 18.623 1.00 12.01 ATOM 3028 N THRH 110 11.781-14.552 19.681 1.00 11.46 ATOM 3030 CA THRH 110 12.306 -14.238 21.009 1.00 11.24 WO 99/10379 PCT/GB98/02542 -256 ATOM 3031 CB THR H 110 11.175 -14.040 22.044 1.00 9.63 ATOM 3032 OGI THRH 110 10.211 -13.106 21.552 1.00 10.83 ATOM 3034 CG2 THR H 110 11.749-13.553 23.348 1.00 8.99 ATOM 3035 C THRH 110 13.132 -15.399 21.501 1.00 7.60 ATOM 3036 O THRH 110 12.632-16.511 21.519 1.00 12.38 ATOM 3037 N VALH 111 14.366-15.155 21.840 1.00 9.00 ATOM 3039 CA VALHI 11 15.217-16.191 22.409 1.0012.99 ATOM 3040 CB VAL H 111 16.629 -16.276 21.720 1.00 10.01 ATOM 3041 CG1 VALH 111 17.395-17.471 22.276 1.00 8.99 ATOM 3042 CG2 VAL H 111 16.484-16.393 20.188 1.00 14.22 ATOM 3043 C VALH 111I 15.450 -15.894 23.907 1.00 13.42 ATOM 3044 O VALH 111 16.248 -15.046 24.261 1.00 14.03 ATOM 3045 N SERH 112 14.814 -16.628 24.769 1.00 15.10 ATOM 3047 CA SERH 112 15.002-16.385 26.179 1.00 17.45 ATOM 3048 CB SERH 112 13.877-15.495 26.689 1.00 17.57 ATOM 3049 OG SERH 112 14.108-15.154 28.028 1.00 18.71 ATOM 3051 C SERH 112 14.966-17.673 26.950 1.00 18.74 ATOM 3052 O SERH 112 14.128-18.522 26.691 1.0021.32 ATOM 3053 N SERH 113 15.847-17.807 27.923 1.0022.03 ATOM 3055 CA SERH 113 15.786-18.966 28.831 1.00 26.34 ATOM 3056 CB SER H 113 17.195 -19.287 29.323 1.00 28.00 ATOM 3057 OG SERH 113 17.820-18.122 29.857 1.00 35.95 ATOM 3059 C SERH 113 14.807-18.758 30.055 1.00 26.98 ATOM 3060 O SER H 113 14.655 -19.664 30.898 1.00 26.75 ATOM 3061 N ALA H 114 14.139 -17.579 30.126 1.0025.34 ATOM 3063 CA ALAH 114 13.236-17.259 31.225 1.0023.14 ATOM 3064 CB ALA H 114 12.850 -15.782 31.187 1.00 22.38 ATOM 3065 C ALAH 114 11.977-18.116 31.207 1.0024.60 ATOM 3066 O ALAH 114 11.432-18.441 30.128 1.0024.23 ATOM 3067 N LYS H 115 11.502 -18.459 32.429 1.00 23.35 ATOM 3069 CA LYS H 115 10.298-19.260 32.595 1.0023.70 ATOM 3070 CB LYSH 115 10.436-20.151 33.818 1.0024.56 ATOM 3071 CG LYSH 115 11.651-21.034 33.784 1.0031.61 ATOM 3072 CD LYSH 115 11.555 -22.124 34.846 1.0037.03 ATOM 3073 CE LYS H 115 12.681 -23.149 34.714 1.0036.28 ATOM 3074 NZ LYSH 115 12.625-24.161 35.810 1.0037.66 ATOM 3078 C LYS H 115 9.075 -18.376 32.767 1.00 21.83 ATOM 3079 O LYS H 115 9.186-17.219 33.163 1.00 19.35 ATOM 3080 N THR H 116 7.896-18.924 32.501 1.00 22.54 ATOM 3082 CA THRH 116 6.699-18.136 32.650 1.00 25.02 ATOM 3083 CB THR H 116 5.433 -18.954 32.354 1.00 28.05 ATOM 3084 OG1 THRH 116 5.489-19.417 30.987 1.00 31.99 ATOM 3086 CG2THRH 116 4.169-18.118 32.551 1.0025.98 ATOM 3087 C THR H 116 6.669-17.593 34.044 1.00 23.95 ATOM 3088 O THRH 116 7.081 -18.264 34.978 1.00 23.92 ATOM 3089 N THRH 117 6.245 -16.372 34.180 1.00 24.46 ATOM 3091 CA THR H 117 6.273 -15.699 35.474 1.00 22.17 ATOM 3092 CB THR H 117 7.625 -14.999 35.667 1.00 22.94 ATOM 3093 OGI THRH 117 8.689-15.967 35.507 1.00 19.91 ATOM 3095 CG2 THR H 117 7.726-14.360 37.046 1.00 25.03 ATOM 3096 C THRH 117 5.154-14.681 35.507 1.0022.41 ATOM 3097 O THRH 117 5.049-13.810 34.631 1.0022.33 ATOM 3098 N PRO H 118 4.248-14.801 36.473 1.00 21.47 ATOM 3099 CD PRO H 118 4.278 -15.766 37.615 1.00 24.37 ATOM 3100 CA PROH 118 3.142-13.877 36.594 1.00 19.44 ATOM 3101 CB PROH 118 2.234-14.580 37.605 1.0021.47 WO 99/10379 PCT/GB98/02542 -257 ATOM 3102 CG PRO H 118 3.232-15.199 38.533 1.00 23.59 ATOM 3103 C PROH 118 3.743-12.587 37.106 1.00 16.22 ATOM 3104 O PROH 118 4.806-12.611 37.749 1.0013.84 ATOM 3105 N PROH 119 3.163-11.443 36.804 1.00 14.35 ATOM 3106 CD PRO H 119 1.953-11.227 35.990 1.00 14.96 ATOM 3107 CA PROH 119 3.728-10.184 37.275 1.00 14.79 ATOM 3108 CB PROH 119 3.056 -9.164 36.380 1.00 13.18 ATOM 3109 CG PROH 119 1.696 -9.745 36.220 1.00 13.05 ATOM 3110 C PROH 119 3.377 -9.958 38.716 1.00 13.65 ATOM 3111 0 PROH 119 2.303-10.393 39.166 1.00 14.64 ATOM 3112 N THRH 120 4.256 -9.314 39.447 1.00 13.96 ATOM 3114 CA THRH 120 3.845 -8.837 40.761 1.00 12.82 ATOM 3115 CB THRH 120 4.977 -8.765 41.775 1.00 5.50 ATOM 3116 OGI THRH 120 5.844 -7.751 41.415 1.00 20.74 ATOM 3118 CG2 THR H 120 5.757 -10.030 41.829 1.00 8.80 ATOM 3119 C THRH 120 3.331 -7.469 40.486 1.00 8.85 ATOM 3120 O THRH 120 4.041 -6.675 39.868 1.00 10.44 ATOM 3121 N VALH 121 2.070 -7.221 40.800 1.00 11.59 ATOM 3123 CA VAL H 121 1.455 -5.913 40.491 1.00 8.52 ATOM 3124 CB VAL H 121 0.016 -6.087 40.012 1.00 6.26 ATOM 3125 CGI VAL H 121 -0.604 -4.736 39.688 1.00 3.84 ATOM 3126 CG2 VAL H 121 0.020 -6.995 38.800 1.00 9.50 ATOM 3127 C VAL H 121 1.505 -4.970 41.692 1.00 12.01 ATOM 3128 0 VALH 121 1.230 -5.376 42.828 1.00 10.41 ATOM 3129 N TYRH 122 1.888 -3.726 41.451 1.00 11.35 ATOM 3131 CA TYRH 122 2.097 -2.781 42.546 1.00 11.02 ATOM 3132 CB TYRH 122 3.596 -2.477 42.719 1.00 7.81 ATOM 3133 CG TYRH 122 4.435 -3.676 43.129 1.00 15.44 ATOM 3134 CDI TYRH 122 4.108 -4.421 44.284 1.00 16.70 ATOM 3135 CE1 TYRH 122 4.872 -5.516 44.695 1.00 12.55 ATOM 3136 CD2TYRH 122 5.555 -4.061 42.394 1.00 7.91 ATOM 3137 CE2TYRH 122 6.327 -5.142 42.788 1.00 8.28 ATOM 3138 CZ TYRH 122 5.989 -5.868 43.948 1.00 11.52 ATOM 3139 OH TYRH 122 6.829 -6.861 44.411 1.00 11.02 ATOM 3141 C TYRH 122 1.367 -1.517 42.256 1.00 12.61 ATOM 3142 O TYRH 122 1.477 -0.956 41.204 1.00 11.44 ATOM 3143 N PRO H 123 0.615 -1.027 43.196 1.00 18.80 ATOM 3144 CD PRO H 123 0.495 -1.532 44.586 1.00 19.13 ATOM 3145 CA PROH 123 -0.158 0.199 43.018 1.00 18.57 ATOM 3146 CB PRO H 123 -1.108 0.142 44.202 1.00 15.86 ATOM 3147 CG PRO H 123 -0.200 -0.377 45.251 1.00 19.34 ATOM 3148 C PROH 123 0.767 1.387 43.094 1.00 18.37 ATOM 3149 O PROH 123 1.745 1.372 43.851 1.0024.31 ATOM 3150 N LEU H 124 0.492 2.394 42.302 1.00 17.89 ATOM 3152 CA LEU H 124 1.279 3.607 42.355 1.00 18.57 ATOM 3153 CB LEU H 124 1.976 3.884 41.033 1.00 17.71 ATOM 3154 CG LEU H 124 2.958 2.812 40.543 1.00 20.67 ATOM 3155 CDI LEUH 124 3.674 3.321 39.317 1.00 18.20 ATOM 3156 CD2 LEU H 124 3.932 2.391 41.659 1.00 18.24 ATOM 3157 C LEU H 124 0.402 4.788 42.763 1.00 18.06 ATOM 3158 O LEUH 124 -0.459 5.263 41.988 1.00 14.26 ATOM 3159 N ALA H 125 0.575 5.193 44.024 1.00 18.65 ATOM 3161 CA ALA H 125 -0.181 6.299 44.575 1.00 16.82 ATOM 3162 CB ALA H 125 -0.606 6.005 46.015 1.00 13.74 ATOM 3163 C ALA H 125 0.678 7.528 44.508 1.00 15.68 ATOM 3164 O ALA H 125 1.893 7.435 44.519 1.00 16.41 WO 99/10379 PCT/GB98/02542 -258 ATOM 3165 N PRO H 126 0.066 8.687 44.406 1.00 16.40 ATOM 3166 CD PROH 126 -1.408 8.891 44.357 1.00 13.85 ATOM 3167 CA PRO H 126 0.790 9.954 44.329 1.00 16.02 ATOM 3168 CB PRO H 126 -0.346 10.988 44.293 1.00 15.53 ATOM 3169 CG PROH 126 -1.468 10.210 43.677 1.00 14.07 ATOM 3170 C PRO H 126 1.753 10.168 45.504 1.00 18.31 ATOM 3171 O PRO H 126 1.470 9.847 46.678 1.00 16.34 ATOM 3172 N GLY H 127 2.898 10.680 45.169 1.00 22.48 ATOM 3174 CA GLY H 127 3.870 10.970 46.171 1.00 30.63 ATOM 3175 C GLYH 127 3.658 12.353 46.704 1.0033.75 ATOM 3176 OTI GLY H 127 4.436 13.259 46.288 1.00 39.27 ATOM 3177 OT2 GLY H 127 2.699 12.543 47.515 1.00 35.28 ATOM 3178 CB ALA H 134 -7.913 19.970 39.281 1.00 21.74 ATOM 3179 C ALAH 134 -8.371 17.522 39.464 1.00 25.40 ATOM 3180 O ALAH 134 -9.444 16.941 39.284 1.0026.02 ATOM 3183 N ALAH 134 -7.293 18.763 41.334 1.0024.67 ATOM 3185 CA ALAH 134 -8.300 18.856 40.227 1.00 23.36 ATOM 3186 N METH 135 -7.220 17.078 38.992 1.0024.22 ATOM 3188 CA METH 135 -7.086 15.795 38.331 1.00 26.09 ATOM 3189 CB METH 135 -6.690 15.998 36.848 1.00 30.45 ATOM 3190 CG METH 135 -7.856 16.182 35.864 1.0034.99 ATOM 3191 SD METH 135 -8.959 14.726 35.832 1.0046.83 ATOM 3192 CE METH 135 -8.963 14.248 34.104 1.0042.78 ATOM 3193 C METH 135 -5.970 15.087 39.063 1.0025.74 ATOM 3194 O METH 135 -5.013 15.747 39.498 1.0025.90 ATOM 3195 N VAL H 136 -6.072 13.787 39.250 1.00 22.09 ATOM 3197 CA VALH 136 -5.000 13.075 39.925 1.00 18.97 ATOM 3198 CB VALH 136 -5.421 12.616 41.358 1.00 16.24 ATOM 3199 CGI VALH 136 -6.664 11.760 41.344 1.00 15.37 ATOM 3200 CG2VALH 136 -4.273 11.897 42.010 1.00 16.51 ATOM 3201 C VALH 136 -4.563 11.886 39.090 1.00 17.30 ATOM 3202 0 VALH 136 -5.405 11.217 38.482 1.00 17.97 ATOM 3203 N THRH 137 -3.256 11.641 39.022 1.00 17.82 ATOM 3205 CA THRH 137 -2.783 10.485 38.267 1.00 18.38 ATOM 3206 CB THRH 137 -1.716 10.872 37.253 1.00 15.72 ATOM 3207 OGI THRH 137 -2.296 11.858 36.377 1.00 16.58 ATOM 3209 CG2THRH 137 -1.310 9.661 36.419 1.00 13.21 ATOM 3210 C THRH 137 -2.294 9.340 39.158 1.00 16.41 ATOM 3211 O THRH 137 -1.419 9.516 40.024 1.00 14.38 ATOM 3212 N LEU H 138 -2.933 8.188 38.935 1.00 13.46 ATOM 3214 CA LEUH 138 -2.625 6.956 39.639 1.00 11.93 ATOM 3215 CB LEU H 138 -3.906 6.404 40.218 1.00 9.54 ATOM 3216 CG LEU H 138 -4.695 7.398 41.034 1.00 9.64 ATOM 3217 CDI LEU H 138 -5.924 6.726 41.571 1.00 11.85 ATOM 3218 CD2 LEU H 138 -3.824 7.938 42.158 1.00 6.56 ATOM 3219 C LEUH 138 -2.053 5.967 38.641 1.00 12.78 ATOM 3220 O LEUH 138 -2.303 6.091 37.448 1.00 10.57 ATOM 3221 N GLYH 139 -1.309 5.004 39.097 1.00 11.80 ATOM 3223 CA GLYH 139 -0.771 4.050 38.164 1.00 11.77 ATOM 3224 C GLY H 139 -0.576 2.690 38.756 1.00 14.58 ATOM 3225 O GLY H 139 -0.870 2.454 39.927 1.00 14.52 ATOM 3226 N CYS H 140 -0.069 1.797 37.952 1.00 13.05 ATOM 3228 CA CYS H 140 0.194 0.461 38.377 1.00 12.15 ATOM 3229 CB CYS H 140 -0.944 -0.465 37.972 1.00 15.82 ATOM 3230 SG CYS H 140 -1.988 -0.926 39.377 1.00 30.05 ATOM 3231 C CYS H 140 1.443 -0.023 37.760 1.00 9.66 WO 99/10379 PCT/GB98/02542 -259 ATOM 3232 O CYS H 140 1.589 0.118 36.543 1.00 8.35 ATOM 3233 N LEU H 141 2.338 -0.552 38.590 1.00 6.85 ATOM 3235 CA LEUH 141 3.558 -1.210 38.113 1.00 10.45 ATOM 3236 CB LEU H 141 4.732 -1.024 39.080 1.00 3.00 ATOM 3237 CG LEU H 141 6.079 -1.654 38.695 1.00 7.34 ATOM 3238 CD1 LEU H 141 6.582 -1.117 37.363 1.00 7.63 ATOM 3239 CD2 LEU H 141 7.118 -1.354 39.745 1.00 2.28 ATOM 3240 C LEU H 141 3.311 -2.709 37.952 1.00 9.22 ATOM 3241 O LEU H 141 2.869 -3.368 38.884 1.00 8.85 ATOM 3242 N VAL H 142 3.557 -3.220 36.756 1.00 10.01 ATOM 3244 CA VAL H 142 3.455 -4.640 36.485 1.00 7.47 ATOM 3245 CB VAL H 142 2.615 -4.880 35.208 1.00 10.12 ATOM 3246 CG1 VALH 142 2.384 -6.392 34.957 1.00 8.96 ATOM 3247 CG2 VAL H 142 1.282 -4.149 35.351 1.00 6.58 ATOM 3248 C VALH 142 4.883 -5.162 36.345 1.00 11.16 ATOM 3249 0 VAL H 142 5.512 -5.095 35.254 1.00 6.29 ATOM 3250 N LYS H 143 5.398 -5.687 37.452 1.00 9.75 ATOM 3252 CA LYS H 143 6.811 -6.007 37.531 1.00 12.16 ATOM 3253 CB LYS H 143 7.354 -5.430 38.840 1.00 9.61 ATOM 3254 CG LYS H 143 8.872 -5.352 38.953 1.00 9.64 ATOM 3255 CD LYS H 143 9.272 -4.908 40.356 1.00 11.17 ATOM 3256 CE LYS H 143 10.790 -4.927 40.518 1.00 15.36 ATOM 3257 NZ LYS H 143 11.194 -4.987 41.953 1.00 13.08 ATOM 3261 C LYS H 143 7.170 -7.505 37.404 1.00 14.70 ATOM 3262 O LYS H 143 6.468 -8.388 37.894 1.00 17.80 ATOM 3263 N GLY H 144 8.247 -7.741 36.666 1.00 16.56 ATOM 3265 CA GLYH 144 8.889 -9.060 36.589 1.00 18.62 ATOM 3266 C GLY H 144 8.106-10.220 36.012 1.00 16.58 ATOM 3267 O GLY H 144 8.220 -11.321 36.532 1.00 20.26 ATOM 3268 N TYRH 145 7.371-10.011 34.931 1.00 15.03 ATOM 3270 CA TYRH 145 6.630-11.111 34.294 1.00 12.99 ATOM 3271 CB TYRH 145 5.217-10.675 33.851 1.00 10.99 ATOM 3272 CG TYRH 145 5.137 -9.598 32.797 1.00 13.14 ATOM 3273 CD1 TYRH 145 5.411 -8.278 33.126 1.00 15.73 ATOM 3274 CEI TYRH 145 5.280 -7.269 32.194 1.00 12.07 ATOM 3275 CD2TYRH 145 4.728 -9.867 31.485 1.00 15.71 ATOM 3276 CE2 TYR H 145 4.598 -8.843 30.532 1.00 9.54 ATOM 3277 CZ TYRH 145 4.879 -7.548 30.902 1.00 10.77 ATOM 3278 OH TYR H 145 4.820 -6.506 29.978 1.00 9.76 ATOM 3280 C TYRH 145 7.389-11.662 33.088 1.00 13.49 ATOM 3281 O TYR H 145 8.389 -11.098 32.669 1.00 12.72 ATOM 3282 N PHE H 146 6.931 -12.800 32.589 1.00 16.82 ATOM 3284 CA PHEH 146 7.455-13.385 31.361 1.00 18.55 ATOM 3285 CB PHEH 146 8.887-13.880 31.495 1.00 18.86 ATOM 3286 CG PHE H 146 9.385 -14.479 30.188 1.0023.23 ATOM 3287 CD1 PHE H 146 10.168 -13.728 29.327 1.00 25.00 ATOM 3288 CD2 PHE H 146 8.957 -15.751 29.761 1.00 24.90 ATOM 3289 CEI PHE H 146 10.506-14.210 28.054 1.00 26.32 ATOM 3290 CE2 PHE H 146 9.282 -16.240 28.506 1.00 26.32 ATOM 3291 CZ PHE H 146 10.054-15.469 27.644 1.00 25.16 ATOM 3292 C PHE H 146 6.642-14.565 31.019 1.00 19.54 ATOM 3293 O PHEH 146 6.360-15.333 31.930 1.00 18.10 ATOM 3294 N PROH 147 6.211 -14.757 29.720 1.0021.47 ATOM 3295 CD PRO H 147 4.961 -15.458 29.393 1.00 21.60 ATOM 3296 CA PRO H 147 6.430-13.882 28.555 1.00 21.86 ATOM 3297 CB PRO H 147 6.205 -14.891 27.401 1.0021.39 WO 99/10379 PCT/GB98/02542 -260 ATOM 3298 CG PRO H 147 5.272 -15.938 28.004 1.00 19.80 ATOM 3299 C PRO H 147 5.429 -12.706 28.486 1.00 18.87 ATOM 3300 O PRO H 147 4.621 -12.537 29.372 1.00 15.77 ATOM 3301 N GLU H 148 5.438 -11.977 27.346 1.00 19.05 ATOM 3303 CA GLU H 148 4.421 -10.976 27.061 1.00 19.21 ATOM 3304 CB GLU H 148 4.991 -9.896 26.155 1.00 17.80 ATOM 3305 CG GLU H 148 6.141 -9.138 26.738 1.00 15.35 ATOM 3306 CD GLU H 148 6.495 -7.945 25.897 1.00 19.90 ATOM 3307 OE GLU H 148 7.607 -7.934 25.314 1.00 23.72 ATOM 3308 OE2 GLU H 148 5.666 -7.006 25.812 1.00 17.13 ATOM 3309 C GLU H 148 3.306-11.661 26.286 1.00 19.80 ATOM 3310 O GLU H 148 3.507 -12.759 25.820 1.0021.47 ATOM 3311 N PROH 149 2.099-11.079 26.136 1.00 19.34 ATOM 3312 CD PRO H 149 0.864-11.830 25.967 1.00 15.47 ATOM 3313 CA PRO H 149 1.670 -9.808 26.680 1.00 18.47 ATOM 3314 CB PRO H 149 0.574 -9.440 25.693 1.00 18.21 ATOM 3315 CG PRO H 149 0.055 -10.797 25.219 1.00 17.16 ATOM 3316 C PROH 149 1.117 -9.890 28.128 1.00 18.85 ATOM 3317 O PRO H 149 1.138-10.912 28.825 1.00 16.35 ATOM 3318 N VAL H 150 0.431 -8.812 28.426 1.00 19.66 ATOM 3320 CA VAL H 150 -0.234 -8.562 29.666 1.00 16.78 ATOM 3321 CB VAL H 150 0.808 -7.952 30.654 1.00 16.55 ATOM 3322 CGI VALH 150 0.424 -6.574 31.111 1.00 17.59 ATOM 3323 CG2 VAL H 150 1.049 -8.879 31.803 1.00 13.17 ATOM 3324 C VAL H 150 -1.328 -7.578 29.276 1.00 16.49 ATOM 3325 0 VALH 150 -1.179 -6.844 28.299 1.00 18.33 ATOM 3326 N THRH 151 -2.454 -7.637 29.908 1.00 14.32 ATOM 3328 CA THRH 151 -3.518 -6.695 29.627 1.00 14.69 ATOM 3329 CB THRH 151 -4.767 -7.415 29.063 1.00 17.81 ATOM 3330 OGI THRH 151 -5.363 -8.243 30.083 1.00 22.14 ATOM 3332 CG2THRH 151 -4.366 -8.318 27.887 1.00 20.30 ATOM 3333 C THRH 151 -3.895 -5.975 30.913 1.00 13.72 ATOM 3334 O THRH 151 -4.185 -6.627 31.907 1.00 13.94 ATOM 3335 N VAL H 152 -3.914 -4.650 30.867 1.00 12.98 ATOM 3337 CA VAL H 152 -4.179 -3.838 32.043 1.00 12.73 ATOM 3338 CB VAL H 152 -2.978 -2.934 32.366 1.00 11.49 ATOM 3339 CG1 VALH 152 -3.293 -2.080 33.597 1.00 11.37 ATOM 3340 CG2 VAL H 152 -1.722 -3.768 32.599 1.00 9.03 ATOM 3341 C VALH 152 -5.406 -2.957 31.861 1.00 15.95 ATOM 3342 0 VAL H 152 -5.471 -2.150 30.915 1.00 19.74 ATOM 3343 N THR H 153 -6.392 -3.130 32.752 1.00 19.44 ATOM 3345 CA THRH 153 -7.597 -2.315 32.735 1.00 19.80 ATOM 3346 CB THRH 153 -8.853 -3.184 32.492 1.00 21.72 ATOM 3347 OG1 THR H 153 -8.787 -4.329 33.329 1.00 26.52 ATOM 3349 CG2THRH 153 -8.933 -3.640 31.043 1.00 21.56 ATOM 3350 C THRH 153 -7.761 -1.516 34.059 1.00 17.98 ATOM 3351 O THRH 153 -7.031 -1.728 35.029 1.00 17.86 ATOM 3352 N TRP H 154 -8.689 -0.566 34.061 1.00 18.02 ATOM 3354 CA TRPH 154 -8.952 0.230 35.234 1.00 16.37 ATOM 3355 CB TRPH 154 -8.433 1.618 35.037 1.00 15.29 ATOM 3356 CG TRPH 154 -6.952 1.646 34.971 1.00 14.01 ATOM 3357 CD2 TRP H 154 -6.067 1.823 36.081 1.00 14.22 ATOM 3358 CE2 TRP H 154 -4.758 1.896 35.568 1.00 12.55 ATOM 3359 CE3 TRP H 154 -6.266 1.949 37.475 1.00 13.71 ATOM 3360 CDI TRP H 154 -6.177 1.600 33.856 1.00 13.72 ATOM 3361 NE1 TRP H 154 -4.866 1.751 34.220 1.00 14.65 WO 99/10379 PCT/GB98/02542 -261 ATOM 3363 CZ2 TRP H 154 -3.652 2.096 36.372 1.00 11.60 ATOM 3364 CZ3 TRP H 154 -5.166 2.157 38.276 1.00 13.74 ATOM 3365 CH2 TRP H 154 -3.873 2.232 37.715 1.00 15.50 ATOM 3366 C TRPH 154 -10.420 0.226 35.491 1.00 16.57 ATOM 3367 O TRPH 154 -11.208 0.455 34.582 1.00 19.07 ATOM 3368 N ASN H 155 -10.778 -0.068 36.722 1.00 18.63 ATOM 3370 CA ASNH 155 -12.180 -0.281 37.110 1.00 19.34 ATOM 3371 CB ASN H 155 -12.891 1.048 37.320 1.00 19.07 ATOM 3372 CG ASN H 155 -12.490 1.668 38.645 1.00 19.37 ATOM 3373 ODI ASN H 155 -11.779 1.057 39.456 1.00 17.72 ATOM 3374 ND2 ASN H 155 -12.921 2.889 38.867 1.00 21.85 ATOM 3377 C ASNH 155 -12.904 -1.170 36.102 1.0020.59 ATOM 3378 O ASN H 155 -13.986 -0.848 35.618 1.00 19.83 ATOM 3379 N SERH 156 -12.241 -2.298 35.766 1.0022.94 ATOM 3381 CA SERH 156 -12.750 -3.259 34.796 1.00 23.80 ATOM 3382 CB SERH 156 -14.038 -3.890 35.323 1.0024.08 ATOM 3383 OG SERH 156 -13.792 -4.576 36.536 1.0023.19 ATOM 3385 C SERH 156 -12.976 -2.658 33.389 1.0026.88 ATOM 3386 O SERH 156 -13.725 -3.203 32.568 1.0029.20 ATOM 3387 N GLY H 157 -12.320 -1.557 33.089 1.00 26.24 ATOM 3389 CA GLYH 157 -12.519 -0.967 31.796 1.00 28.52 ATOM 3390 C GLYH 157 -13.571 0.138 31.791 1.0028.13 ATOM 3391 O GLYH 157 -13.806 0.760 30.749 1.0028.70 ATOM 3392 N SERH 158 -14.208 0.382 32.944 1.0027.82 ATOM 3394 CA SERH 158 -15.168 1.460 33.047 1.0027.17 ATOM 3395 CB SERH 158 -16.060 1.313 34.323 1.0028.51 ATOM 3396 OG SERH 158 -15.374 1.579 35.535 1.00 25.88 ATOM 3398 C SERH 158 -14.409 2.776 33.013 1.0027.55 ATOM 3399 O SERH 158 -14.917 3.781 32.545 1.0028.23 ATOM 3400 N LEUH 159 -13.174 2.756 33.524 1.0029.42 ATOM 3402 CA LEU H 159 -12.285 3.894 33.378 1.00 30.68 ATOM 3403 CB LEUH 159 -11.275 3.969 34.519 1.0031.18 ATOM 3404 CG LEU H 159 -11.742 4.647 35.816 1.00 29.87 ATOM 3405 CD1 LEU H 159 -10.617 4.653 36.846 1.00 34.45 ATOM 3406 CD2 LEU H 159 -12.180 6.062 35.529 1.0029.03 ATOM 3407 C LEUH 159 -11.562 3.691 32.072 1.0031.97 ATOM 3408 O LEUH 159 -10.552 3.001 32.022 1.0031.21 ATOM 3409 N ALAH 160 -12.155 4.217 31.009 1.0034.61 ATOM 3411 CA ALAH 160 -11.612 4.062 29.651 1.0035.80 ATOM 3412 CB ALA H 160 -12.774 3.835 28.686 1.0034.51 ATOM 3413 C ALA H 160 -10.777 5.293 29.237 1.0035.27 ATOM 3414 O ALA H 160 -9.618 5.185 28.786 1.00 34.38 ATOM 3415 N SERH 161 -11.364 6.459 29.407 1.00 33.77 ATOM 3417 CA SERH 161 -10.671 7.704 29.107 1.00 33.98 ATOM 3418 CB SERH 161 -11.692 8.842 29.075 1.0033.96 ATOM 3419 OG SERH 161 -12.991 8.335 28.755 1.00 38.30 ATOM 3421 C SERH 161 -9.605 7.996 30.175 1.00 30.88 ATOM 3422 O SERH 161 -9.745 7.604 31.345 1.00 32.73 ATOM 3423 N GLY H 162 -8.540 8.664 29.773 1.0028.58 ATOM 3425 CA GLY H 162 -7.509 9.053 30.740 1.00 23.36 ATOM 3426 C GLYH 162 -6.481 7.985 31.068 1.00 19.44 ATOM 3427 O GLYH 162 -5.660 8.182 31.988 1.00 17.19 ATOM 3428 N VAL H 163 -6.484 6.886 30.290 1.00 16.90 ATOM 3430 CA VAL H 163 -5.563 5.790 30.522 1.00 14.28 ATOM 3431 CB VALH 163 -6.248 4.447 30.286 1.00 11.19 ATOM 3432 CGI VALH 163 -5.249 3.311 30.466 1.00 9.55 WO 99/10379 PCT/GB98/02542 -262 ATOM 3433 CG2 VAL H 163 -7.394 4.309 31.280 1.00 8.14 ATOM 3434 C VAL H 163 -4.334 5.883 29.638 1.00 16.70 ATOM 3435 0 VAL H 163 -4.426 6.310 28.494 1.00 20.46 ATOM 3436 N HIS H 164 -3.208 5.502 30.172 1.00 12.44 ATOM 3438 CA HIS H 164 -1.976 5.465 29.432 1.00 12.24 ATOM 3439 CB HIS H 164 -1.063 6.591 29.851 1.00 12.04 ATOM 3440 CG HIS H 164 -1.358 7.848 29.188 1.00 17.45 ATOM 3441 CD2 HIS H 164 -1.800 9.033 29.657 1.00 16.45 ATOM 3442 NDI HIS H 164 -1.111 8.037 27.847 1.00 19.78 ATOM 3444 CEl HIS H 164 -1.352 9.251 27.488 1.00 18.88 ATOM 3445 NE2 HIS H 164 -1.763 9.876 28.571 1.00 19.92 ATOM 3447 C HIS H 164 -1.262 4.216 29.770 1.00 12.66 ATOM 3448 O HIS H 164 -0.943 4.023 30.924 1.00 12.50 ATOM 3449 N THRH 165 -1.030 3.348 28.825 1.00 12.38 ATOM 3451 CA THRH 165 -0.208 2.196 29.132 1.00 10.10 ATOM 3452 CB THRH 165 -0.949 0.879 28.952 1.00 9.55 ATOM 3453 OG1 THRH 165 -2.152 0.949 29.722 1.00 11.21 ATOM 3455 CG2 THRH 165 -0.115 -0.286 29.439 1.00 8.04 ATOM 3456 C THRH 165 1.042 2.239 28.295 1.00 11.67 ATOM 3457 O THRH 165 0.977 2.443 27.089 1.00 10.32 ATOM 3458 N PHEH 166 2.174 2.052 28.974 1.00 11.57 ATOM 3460 CA PHE H 166 3.499 2.190 28.390 1.00 12.01 ATOM 3461 CB PHE H 166 4.382 2.951 29.407 1.00 9.65 ATOM 3462 CG PHE H 166 3.765 4.283 29.822 1.00 8.07 ATOM 3463 CD1 PHE H 166 2.849 4.351 30.868 1.00 4.17 ATOM 3464 CD2 PHE H 166 4.004 5.456 29.073 1.00 10.68 ATOM 3465 CE1 PHEH 166 2.155 5.547 31.155 1.00 8.24 ATOM 3466 CE2PHEH 166 3.314 6.654 29.355 1.00 11.02 ATOM 3467 CZ PHEH 166 2.386 6.698 30.394 1.00 5.44 ATOM 3468 C PHEH 166 4.116 0.815 28.006 1.00 15.40 ATOM 3469 O PHE H 166 3.583 -0.249 28.404 1.00 16.48 ATOM 3470 N PRO H 167 5.210 0.826 27.164 1.0014.51 ATOM 3471 CD PRO H 167 5.803 2.030 26.521 1.00 14.57 ATOM 3472 CA PRO H 167 5.919 -0.378 26.684 1.00 13.56 ATOM 3473 CB PRO H 167 6.884 0.166 25.595 1.00 15.95 ATOM 3474 CG PRO H 167 6.303 1.479 25.213 1.00 15.19 ATOM 3475 C PRO H 167 6.720 -1.095 27.757 1.00 13.70 ATOM 3476 O PRO H 167 7.321 -0.457 28.630 1.00 8.91 ATOM 3477 N ALA H 168 6.767 -2.424 27.618 1.00 14.48 ATOM 3479 CA ALA H 168 7.506 -3.277 28.526 1.00 13.11 ATOM 3480 CB ALA H 168 7.212 -4.746 28.240 1.00 12.04 ATOM 3481 C ALA H 168 8.982 -3.020 28.403 1.00 15.12 ATOM 3482 O ALA H 168 9.496 -2.687 27.332 1.00 14.20 ATOM 3483 N VAL H 169 9.661 -3.093 29.519 1.00 14.23 ATOM 3485 CA VAL H 169 11.077 -2.965 29.524 1.00 11.53 ATOM 3486 CB VALH 169 11.614 -1.828 30.480 1.00 10.77 ATOM 3487 CGI VALH 169 11.381 -0.451 29.880 1.00 5.38 ATOM 3488 CG2 VAL H 169 10.921 -1.887 31.820 1.00 8.65 ATOM 3489 C VAL H 169 11.569 -4.309 29.970 1.00 14.43 ATOM 3490 0 VAL H 169 10.861 -4.991 30.697 1.00 13.16 ATOM 3491 N LEU H 170 12.714 -4.721 29.457 1.00 16.49 ATOM 3493 CA LEU H 170 13.336 -5.954 29.891 1.00 20.55 ATOM 3494 CB LEU H 170 13.963 -6.711 28.694 1.00 17.41 ATOM 3495 CG LEU H 170 14.387 -8.182 28.942 1.00 16.89 ATOM 3496 CDI LEUH 170 13.184 -9.004 29.309 1.00 11.20 ATOM 3497 CD2 LEU H 170 15.058 -8.781 27.707 1.00 13.43 WO 99/10379 PCT/GB98/02542 -263 ATOM 3498 C LEU H 170 14.400 -5.625 30.916 1.00 21.20 ATOM 3499 O LEU H 170 15.390 -4.963 30.619 1.0023.98 ATOM 3500 N GLNH 171 14.169 -6.028 32.146 1.0025.48 ATOM 3502 CA GLN H 171 15.157 -5.823 33.175 1.0027.97 ATOM 3503 CB GLNH 171 14.916 -4.492 33.962 1.0033.14 ATOM 3504 CG GLN H 171 13.467 -4.068 34.268 1.00 35.78 ATOM 3505 CD GLNH 171 13.319 -2.530 34.449 1.0041.72 ATOM 3506 OEl GLNH 171 14.162 -1.751 33.979 1.0043.19 ATOM 3507 NE2 GLN H 171 12.253 -2.078 35.114 1.00 39.50 ATOM 3510 C GLN H 171 15.230 -7.042 34.083 1.00 30.85 ATOM 3511 O GLN H 171 14.312 -7.308 34.873 1.0030.30 ATOM 3512 N ALA H 172 16.307 -7.817 33.893 1.0030.98 ATOM 3514 CA ALA H 172 16.568 -9.039 34.690 1.00 32.89 ATOM 3515 CB ALA H 172 16.053 -8.885 36.145 1.00 34.56 ATOM 3516 C ALA H 172 15.964 -10.291 34.039 1.0032.42 ATOM 3517 O ALAH 172 15.553-11.239 34.741 1.0033.51 ATOM 3518 N ALAH 173 15.982-10.303 32.683 1.0028.84 ATOM 3520 CA ALAH 173 15.370-11.366 31.889 1.0024.12 ATOM 3521 CB ALA H 173 15.884 -12.754 32.279 1.00 24.73 ATOM 3522 C ALA H 173 13.860 -11.329 32.002 1.0022.90 ATOM 3523 O ALAH 173 13.186 -12.169 31.437 1.0024.63 ATOM 3524 N LEU H 174 13.314-10.347 32.714 1.00 19.03 ATOM 3526 CA LEUH 174 11.868-10.284 32.897 1.00 16.09 ATOM 3527 CB LEU H 174 11.502-10.527 34.386 1.00 13.53 ATOM 3528 CG LEU H 174 11.823 -11.921 35.008 1.00 13.70 ATOM 3529 CD1 LEUH 174 11.399-11.927 36.487 1.00 13.19 ATOM 3530 CD2 LEU H 174 11.093 -13.033 34.243 1.00 7.07 ATOM 3531 C LEUH 174 11.366 -8.934 32.444 1.00 11.64 ATOM 3532 O LEU H 174 12.095 -7.980 32.520 1.00 13.03 ATOM 3533 N TYRH 175 10.153 -8.887 31.980 1.00 11.45 ATOM 3535 CA TYRH 175 9.546 -7.644 31.500 1.00 13.69 ATOM 3536 CB TYRH 175 8.505 -7.917 30.412 1.00 13.82 ATOM 3537 CG TYRH 175 9.047 -8.559 29.178 1.00 14.75 ATOM 3538 CD1 TYRH 175 9.965 -7.890 28.395 1.00 17.41 ATOM 3539 CE1 TYRH 175 10.503 -8.454 27.241 1.00 18.34 ATOM 3540 CD2 TYRH 175 8.651 -9.827 28.790 1.00 18.01 ATOM 3541 CE2 TYR H 175 9.174-10.408 27.633 1.00 20.37 ATOM 3542 CZ TYRH 175 10.106 -9.710 26.864 1.00 19.65 ATOM 3543 OH TYRH 175 10.628-10.265 25.726 1.00 21.14 ATOM 3545 C TYRH 175 8.813 -6.864 32.614 1.00 16.88 ATOM 3546 O TYR H 175 8.188 -7.448 33.534 1.00 15.69 ATOM 3547 N THRH 176 8.827 -5.545 32.462 1.00 14.27 ATOM 3549 CA THRH 176 8.125 -4.654 33.374 1.00 13.28 ATOM 3550 CB THRH 176 9.101 -3.932 34.349 1.00 11.07 ATOM 3551 OGI THRH 176 9.699 -4.857 35.280 1.00 9.99 ATOM 3553 CG2 THR H 176 8.353 -2.855 35.118 1.00 7.94 ATOM 3554 C THR H 176 7.416 -3.584 32.574 1.00 11.40 ATOM 3555 O THRH 176 8.015 -2.999 31.677 1.00 10.96 ATOM 3556 N LEU H 177 6.156 -3.347 32.837 1.00 9.44 ATOM 3558 CA LEUH 177 5.528 -2.190 32.216 1.00 11.96 ATOM 3559 CB LEU H 177 4.765 -2.521 30.918 1.00 12.44 ATOM 3560 CG LEUH 177 3.542 -3.432 30.927 1.00 13.51 ATOM 3561 CD1 LEU H 177 2.348 -2.762 31.611 1.00 16.92 ATOM 3562 CD2 LEU H 177 3.176 -3.748 29.478 1.00 19.97 ATOM 3563 C LEUH 177 4.689 -1.442 33.231 1.00 11.72 ATOM 3564 O LEU H 177 4.664 -1.831 34.398 1.00 12.02 WO 99/10379 PCT/GB98/02542 -264 ATOM 3565 N SERH 178 4.091 -0.356 32.826 1.00 9.83 ATOM 3567 CA SERH 178 3.261 0.429 33.720 1.00 12.66 ATOM 3568 CB SER H 178 3.993 1.665 34.273 1.00 16.23 ATOM 3569 OG SERH 178 5.061 1.325 35.106 1.0021.15 ATOM 3571 C SERH 178 2.068 0.941 32.983 1.0011.78 ATOM 3572 O SER H 178 2.047 0.979 31.760 1.00 12.05 ATOM 3573 N SERH 179 1.096 1.333 33.750 1.00 10.09 ATOM 3575 CA SERH 179 -0.086 1.954 33.244 1.00 9.78 ATOM 3576 CB SERH 179 -1.225 0.943 33.162 1.00 7.12 ATOM 3577 OG SERH 179 -2.371 1.448 32.486 1.00 13.99 ATOM 3579 C SERH 179 -0.437 3.044 34.227 1.00 11.73 ATOM 3580 O SERH 179 0.004 3.012 35.394 1.00 10.99 ATOM 3581 N SERH 180 -1.192 3.999 33.772 1.0012.62 ATOM 3583 CA SERH 180 -1.629 5.088 34.616 1.00 11.78 ATOM 3584 CB SERH 180 -0.622 6.247 34.486 1.00 15.26 ATOM 3585 OG SERH 180 -0.758 6.938 33.258 1.00 15.98 ATOM 3587 C SERH 180 -3.039 5.538 34.206 1.00 11.26 ATOM 3588 O SER H 180 -3.413 5.318 33.063 1.00 12.64 ATOM 3589 N VAL H 181 -3.841 6.068 35.170 1.00 12.70 ATOM 3591 CA VAL H 181 -5.143 6.697 34.893 1.00 12.65 ATOM 3592 CB VAL H 181 -6.394 6.148 35.602 1.00 14.52 ATOM 3593 CG1 VALH 181 -7.465 5.808 34.616 1.00 8.51 ATOM 3594 CG2 VAL H 181 -6.086 5.076 36.606 1.00 15.67 ATOM 3595 C VAL H 181 -5.126 8.065 35.510 1.00 13.40 ATOM 3596 0 VALH 181 -4.564 8.238 36.571 1.00 10.66 ATOM 3597 N THRH 182 -5.816 8.994 34.864 1.00 15.42 ATOM 3599 CA THRH 182 -6.029 10.300 35.418 1.00 12.05 ATOM 3600 CB THRH 182 -5.483 11.393 34.504 1.00 12.00 ATOM 3601 OGI THRH 182 -4.068 11.185 34.369 1.00 12.34 ATOM 3603 CG2THRH 182 -5.731 12.786 35.097 1.00 10.88 ATOM 3604 C THRH 182 -7.505 10.452 35.623 1.00 15.30 ATOM 3605 O THRH 182 -8.310 10.221 34.702 1.00 15.69 ATOM 3606 N VALH 183 -7.851 10.747 36.872 1.00 15.89 ATOM 3608 CA VAL H 183 -9.237 10.912 37.302 1.00 15.70 ATOM 3609 CB VALH 183 -9.692 9.772 38.276 1.00 13.11 ATOM 3610 CG1 VAL H 183 -9.861 8.472 37.519 1.00 16.73 ATOM 3611 CG2VALH 183 -8.678 9.585 39.374 1.00 7.49 ATOM 3612 C VAL H 183 -9.375 12.221 38.050 1.00 14.30 ATOM 3613 0 VALH 183 -8.395 12.760 38.516 1.00 15.26 ATOM 3614 N PROH 184 -10.592 12.768 38.177 1.00 15.74 ATOM 3615 CD PRO H 184 -11.860 12.255 37.668 1.00 15.39 ATOM 3616 CA PRO H 184 -10.784 14.007 38.906 1.00 16.30 ATOM 3617 CB PRO H 184 -12.282 14.289 38.757 1.00 15.06 ATOM 3618 CG PRO H 184 -12.662 13.516 37.544 1.00 15.56 ATOM 3619 C PRO H 184 -10.429 13.704 40.341 1.00 15.62 ATOM 3620 O PROH 184 -10.859 12.707 40.872 1.00 17.90 ATOM 3621 N SERH 185 -9.648 14.527 40.960 1.0021.17 ATOM 3623 CA SERH 185 -9.288 14.311 42.349 1.0023.69 ATOM 3624 CB SER H 185 -8.371 15.436 42.815 1.00 26.61 ATOM 3625 OG SERH 185 -8.807 16.685 42.271 1.0031.23 ATOM 3627 C SERH 185 -10.533 14.241 43.255 1.0026.32 ATOM 3628 O SERH 185 -10.466 13.737 44.376 1.0029.50 ATOM 3629 N SERH 186 -11.681 14.743 42.795 1.0025.25 ATOM 3631 CA SERH 186 -12.880 14.649 43.614 1.00 25.46 ATOM 3632 CB SERH 186 -14.011 15.504 43.021 1.00 26.27 ATOM 3633 OG SERH 186 -14.531 14.972 41.797 1.0029.82 WO 99/10379 PCT/GB98/02542 -265 ATOM 3635 C SERH 186 -13.358 13.185 43.753 1.0024.07 ATOM 3636 O SERH 186 -14.198 12.904 44.574 1.0024.17 ATOM 3637 N THRH 187 -12.808 12.260 42.950 1.0021.70 ATOM 3639 CA THRH 187 -13.302 10.870 42.943 1.0021.99 ATOM 3640 CB THRH 187 -13.701 10.448 41.520 1.0020.90 ATOM 3641 OGI THRH 187 -12.531 10.455 40.684 1.00 18.99 ATOM 3643 CG2THRH 187 -14.724 11.409 40.950 1.00 18.74 ATOM 3644 C THRH 187 -12.278 9.864 43.489 1.0023.01 ATOM 3645 O THRH 187 -12.507 8.646 43.487 1.0023.61 ATOM 3646 N TRP H 188 -11.142 10.380 43.909 1.0020.48 ATOM 3648 CA TRP H 188 -10.135 9.575 44.530 1.00 21.24 ATOM 3649 CB TRPH 188 -9.132 8.968 43.515 1.00 15.29 ATOM 3650 CG TRPH 188 -8.154 8.007 44.178 1.00 11.67 ATOM 3651 CD2 TRP H 188 -6.858 8.324 44.777 1.00 8.04 ATOM 3652 CE2 TRP H 188 -6.335 7.128 45.303 1.00 8.99 ATOM 3653 CE3 TRP H 188 -6.099 9.504 44.933 1.00 8.90 ATOM 3654 CD1 TRPH 188 -8.344 6.654 44.375 1.00 13.61 ATOM 3655 NEI TRPH 188 -7.254 6.147 45.044 1.00 14.95 ATOM 3657 CZ2 TRP H 188 -5.091 7.071 45.959 1.00 12.53 ATOM 3658 CZ3 TRP H 188 -4.876 9.447 45.589 1.00 10.52 ATOM 3659 CH2 TRP H 188 -4.377 8.233 46.092 1.00 12.29 ATOM 3660 C TRP H 188 -9.392 10.463 45.500 1.00 20.69 ATOM 3661 O TRPH 188 -8.931 11.541 45.126 1.0020.70 ATOM 3662 N PRO H 189 -9.147 9.971 46.705 1.0020.09 ATOM 3663 CD PRO H 189 -8.337 10.643 47.748 1.00 22.74 ATOM 3664 CA PRO H 189 -9.526 8.624 47.137 1.00 20.72 ATOM 3665 CB PRO H 189 -8.474 8.329 48.184 1.00 22.60 ATOM 3666 CG PRO H 189 -8.368 9.640 48.878 1.00 20.47 ATOM 3667 C PRO H 189 -10.918 8.383 47.687 1.0021.08 ATOM 3668 O PROH 189 -11.094 7.394 48.358 1.0022.85 ATOM 3669 N SERH 190 -11.905 9.217 47.423 1.0023.42 ATOM 3671 CA SERH 190 -13.246 8.941 47.944 1.0021.96 ATOM 3672 CB SERH 190 -14.182 10.102 47.648 1.0023.31 ATOM 3673 OG SERH 190 -14.424 10.227 46.247 1.0023.23 ATOM 3675 C SERH 190 -13.818 7.676 47.324 1.0024.54 ATOM 3676 O SERH 190 -14.576 6.938 48.002 1.00 25.15 ATOM 3677 N GLU H 191 -13.510 7.456 45.998 1.0025.58 ATOM 3679 CA GLU H 191 -13.957 6.241 45.283 1.00 23.69 ATOM 3680 CB GLU H 191 -14.744 6.550 43.995 1.0025.22 ATOM 3681 CG GLUH 191 -15.871 7.579 44.161 1.0028.53 ATOM 3682 CD GLU H 191 -16.929 7.228 45.217 1.0028.30 ATOM 3683 OEI GLU H 191 -16.805 6.175 45.880 1.00 31.06 ATOM 3684 OE2 GLU H 191 -17.893 8.014 45.380 1.00 26.40 ATOM 3685 C GLUH 191 -12.795 5.367 44.946 1.00 23.74 ATOM 3686 O GLUH 191 -11.649 5.817 44.905 1.0021.49 ATOM 3687 N THRH 192 -13.101 4.120 44.702 1.0020.79 ATOM 3689 CA THRH 192 -12.082 3.128 44.463 1.00 21.97 ATOM 3690 CB THRH 192 -12.627 1.714 44.722 1.00 23.80 ATOM 3691 OGI THRH 192 -13.073 1.631 46.085 1.00 29.80 ATOM 3693 CG2THRH 192 -11.541 0.666 44.485 1.00 27.22 ATOM 3694 C THRH 192 -11.552 3.164 43.062 1.00 18.87 ATOM 3695 O THRH 192 -12.316 3.259 42.102 1.00 15.94 ATOM 3696 N VALH 193 -10.243 3.098 42.963 1.00 16.81 ATOM 3698 CA VAL H 193 -9.596 2.918 41.685 1.00 16.97 ATOM 3699 CB VAL H 193 -8.801 4.205 41.206 1.00 16.54 ATOM 3700 CG1 VALH 193 -7.941 3.913 39.955 1.00 11.61 WO 99/10379 PCT/GB98/02542 -266 ATOM 3701 CG2 VAL H 193 -9.818 5.319 40.874 1.00 14.87 ATOM 3702 C VAL H 193 -8.720 1.648 41.779 1.00 16.78 ATOM 3703 0 VALH 193 -7.864 1.514 42.626 1.00 14.37 ATOM 3704 N THRH 194 -9.039 0.689 40.945 1.00 18.51 ATOM 3706 CA THRH 194 -8.348 -0.571 40.933 1.00 19.26 ATOM 3707 CB THRH 194 -9.335 -1.672 41.312 1.00 19.05 ATOM 3708 OGI THRH 194 -10.070 -1.255 42.476 1.00 22.10 ATOM 3710 CG2THRH 194 -8.625 -2.980 41.603 1.00 17.95 ATOM 3711 C THRH 194 -7.871 -0.842 39.523 1.0020.35 ATOM 3712 O THRH 194 -8.575 -0.528 38.560 1.00 18.99 ATOM 3713 N CYS H 195 -6.683 -1.388 39.389 1.0022.03 ATOM 3715 CA CYSH 195 -6.241 -1.842 38.090 1.00 21.55 ATOM 3716 CB CYS H 195 -4.838 -1.374 37.790 1.00 22.21 ATOM 3717 SG CYS H 195 -3.531 -2.325 38.567 1.0026.24 ATOM 3718 C CYS H 195 -6.320 -3.360 38.049 1.00 20.83 ATOM 3719 O CYSH 195 -6.051 -4.058 39.040 1.0021.96 ATOM 3720 N ASNH 196 -6.712 -3.850 36.908 1.00 19.29 ATOM 3722 CA ASN H 196 -6.924 -5.280 36.675 1.00 16.40 ATOM 3723 CB ASN H 196 -8.297 -5.433 36.030 1.00 16.17 ATOM 3724 CG ASN H 196 -9.253 -4.392 36.544 1.00 13.27 ATOM 3725 OD1 ASN H 196 -9.664 -3.475 35.837 1.00 20.19 ATOM 3726 ND2ASNH 196 -9.596 -4.510 37.798 1.00 11.17 ATOM 3729 C ASN H 196 -5.879 -5.762 35.690 1.00 16.19 ATOM 3730 O ASN H 196 -5.901 -5.343 34.545 1.00 13.42 ATOM 3731 N VAL H 197 -4.956 -6.602 36.133 1.00 15.57 ATOM 3733 CA VAL H 197 -3.897 -7.065 35.269 1.00 14.42 ATOM 3734 CB VALH 197 -2.521 -6.834 35.890 1.00 9.60 ATOM 3735 CG1 VALH 197 -1.458 -7.389 34.966 1.00 7.11 ATOM 3736 CG2 VAL H 197 -2.290 -5.354 36.125 1.00 12.01 ATOM 3737 C VAL H 197 -4.033 -8.547 34.954 1.00 16.35 ATOM 3738 0 VALH 197 -4.129 -9.376 35.874 1.00 14.56 ATOM 3739 N ALA H 198 -4.033 -8.874 33.646 1.00 17.13 ATOM 3741 CA ALAH 198 -4.135 -10.267 33.214 1.00 16.34 ATOM 3742 CB ALA H 198 -5.315 -10.444 32.302 1.00 17.48 ATOM 3743 C ALA H 198 -2.881 -10.680 32.503 1.00 18.98 ATOM 3744 O ALA H 198 -2.337 -9.926 31.692 1.00 18.73 ATOM 3745 N HISH 199 -2.372-11.845 32.860 1.00 18.76 ATOM 3747 CA HIS H 199 -1.205 -12.400 32.205 1.00 17.07 ATOM 3748 CB HIS H 199 -0.048 -12.500 33.166 1.00 8.69 ATOM 3749 CG HIS H 199 1.206 -12.959 32.494 1.00 13.16 ATOM 3750 CD2HISH 199 1.784-12.605 31.294 1.00 11.24 ATOM 3751 ND1 HIS H 199 2.076 -13.871 33.056 1.00 12.67 ATOM 3753 CEI HIS H 199 3.134 -14.074 32.278 1.00 15.05 ATOM 3754 NE2 HIS H 199 2.957-13.318 31.211 1.00 9.04 ATOM 3756 C HIS H 199 -1.582 -13.790 31.698 1.0020.77 ATOM 3757 O HIS H 199 -1.357 -14.809 32.404 1.00 22.61 ATOM 3758 N PRO H 200 -2.203 -13.855 30.485 1.00 23.38 ATOM 3759 CD PRO H 200 -2.513 -12.705 29.583 1.00 23.82 ATOM 3760 CA PRO H 200 -2.640-15.113 29.875 1.0022.74 ATOM 3761 CB PRO H 200 -2.769-14.750 28.407 1.00 23.09 ATOM 3762 CG PRO H 200 -3.303 -13.357 28.477 1.00 23.84 ATOM 3763 C PRO H 200 -1.671 -16.255 30.118 1.0022.03 ATOM 3764 O PRO H 200 -2.091 -17.283 30.570 1.00 25.71 ATOM 3765 N ALA H201 -0.382 -16.054 29.884 1.0021.74 ATOM 3767 CA ALA H201 0.601 -17.137 30.024 1.00 22.02 ATOM 3768 CB ALA H 201 1.987-16.614 29.751 1.0021.34 WO 99/10379 PCT/GB98/02542 -267 ATOM 3769 C ALA H 201 0.582 -17.840 31.399 1.0025.49 ATOM 3770 O ALA H 201 0.590 -19.087 31.481 1.0027.00 ATOM 3771 N SER H 202 0.588-17.055 32.476 1.0023.97 ATOM 3773 CA SER H 202 0.534 -17.616 33.826 1.0023.02 ATOM 3774 CB SER H 202 1.046-16.570 34.790 1.0020.89 ATOM 3775 OG SER H 202 0.321 -15.372 34.570 1.00 22.36 ATOM 3777 C SER H 202 -0.908 -17.948 34.194 1.0022.44 ATOM 3778 O SER H 202 -1.196 -18.417 35.282 1.00 24.26 ATOM 3779 N ALA H 203 -1.807 -17.686 33.281 1.0023.52 ATOM 3781 CA ALA H 203 -3.226-17.820 33.547 1.00 24.82 ATOM 3782 CB ALA H203 -3.599 -19.299 33.632 1.0025.98 ATOM 3783 C ALA H 203 -3.628 -17.046 34.835 1.0028.71 ATOM 3784 O ALA H 203 -4.398 -17.533 35.678 1.00 33.42 ATOM 3785 N THR H 204 -3.134-15.820 34.995 1.0027.17 ATOM 3787 CA THRH 204 -3.493 -15.056 36.184 1.00 27.24 ATOM 3788 CB THR H 204 -2.281 -14.722 37.006 1.00 26.73 ATOM 3789 OG1 THR H 204 -1.396-13.917 36.233 1.0029.32 ATOM 3791 CG2 THR H 204 -1.572 -15.997 37.415 1.00 30.85 ATOM 3792 C THR H 204 -4.211-13.756 35.845 1.0028.10 ATOM 3793 O THR H 204 -4.034 -13.185 34.756 1.0027.08 ATOM 3794 N LYS H 205 -5.018 -13.308 36.796 1.0029.70 ATOM 3796 CA LYS H 205 -5.805 -12.082 36.664 1.00 29.70 ATOM 3797 CB LYS H 205 -7.176 -12.423 36.058 1.00 26.59 ATOM 3798 CG LYS H 205 -8.106-11.253 35.801 1.0030.12 ATOM 3799 CD LYS H 205 -7.440-10.121 35.041 1.0032.29 ATOM 3800 CE LYS H 205 -8.413 -8.995 34.687 1.0028.46 ATOM 3801 NZ LYS H 205 -9.228 -9.292 33.456 1.00 32.30 ATOM 3805 C LYS H 205 -5.915 -11.443 38.056 1.00 29.50 ATOM 3806 O LYS H 205 -6.683 -11.903 38.906 1.00 29.82 ATOM 3807 N VAL H 206 -5.087-10.414 38.287 1.0027.91 ATOM 3809 CA VAL H 206 -5.029 -9.767 39.575 1.00 27.55 ATOM 3810 CB VAL H 206 -3.560 -9.755 40.139 1.0027.51 ATOM 3811 CG1 VAL H 206 -2.906 -11.112 39.930 1.00 29.90 ATOM 3812 CG2VAL H 206 -2.727 -8.654 39.511 1.0025.31 ATOM 3813 C VAL H206 -5.598 -8.334 39.578 1.0026.86 ATOM 3814 0 VAL H 206 -5.492 -7.595 38.607 1.00 25.39 ATOM 3815 N ASP H207 -6.229 -7.982 40.701 1.0027.63 ATOM 3817 CA ASP H 207 -6.728 -6.638 40.940 1.00 25.50 ATOM 3818 CB ASP H 207 -8.156 -6.677 41.442 1.0028.55 ATOM 3819 CG ASP H207 -9.132 -6.941 40.337 1.0029.54 ATOM 3820 ODI ASP H 207 -8.700 -6.972 39.168 1.00 36.07 ATOM 3821 OD2ASP H 207 -10.328 -7.118 40.628 1.0032.67 ATOM 3822 C ASP H 207 -5.903 -5.997 42.008 1.00 24.44 ATOM 3823 O ASP H 207 -5.547 -6.682 42.978 1.00 23.66 ATOM 3824 N ALA H 208 -5.581 -4.706 41.827 1.00 21.43 ATOM 3826 CA ALA H208 -4.881 -3.943 42.848 1.00 17.91 ATOM 3827 CB ALA H 208 -3.397 -3.781 42.534 1.0020.11 ATOM 3828 C ALA H 208 -5.530 -2.574 43.035 1.00 16.62 ATOM 3829 O ALA H208 -5.610 -1.753 42.086 1.00 10.62 ATOM 3830 N LYS H 209 -6.055 -2.358 44.261 1.00 16.90 ATOM 3832 CA LYS H 209 -6.683 -1.079 44.621 1.00 15.48 ATOM 3833 CB LYS H209 -7.654 -1.222 45.812 1.00 10.13 ATOM 3834 CG LYS H 209 -8.265 0.104 46.179 0.50 10.96 ATOM 3835 CD LYS H 209 -9.145 -0.022 47.396 0.50 14.26 ATOM 3836 CE LYS H 209 -9.497 1.346 47.938 0.50 12.83 ATOM 3837 NZ LYS H 209 -10.519 1.255 49.008 0.50 14.36 WO 99/10379 PCT/GB98/02542 -268 ATOM 3841 C LYS H 209 -5.627 -0.011 44.930 1.00 12.92 ATOM 3842 O LYS H 209 -4.648 -0.268 45.616 1.00 10.83 ATOM 3843 N ILEH210 -5.801 1.183 44.380 1.00 12.54 ATOM 3845 CA ILE H210 -4.850 2.250 44.663 1.00 14.57 ATOM 3846 CB ILE H210 -4.682 3.263 43.473 1.00 10.03 ATOM 3847 CG2ILE H 210 -3.430 4.074 43.671 1.00 9.58 ATOM 3848 CGI ILEH210 -4.643 2.540 42.097 1.00 11.38 ATOM 3849 CD ILEH210 -3.468 1.613 41.881 1.00 9.16 ATOM 3850 C ILEH210 -5.369 2.976 45.910 1.00 16.98 ATOM 3851 O ILEH210 -6.514 3.474 45.936 1.0018.38 ATOM 3852 N VAL H 211 -4.543 2.941 46.931 1.0019.13 ATOM 3854 CA VAL H 211 -4.831 3.528 48.240 1.0020.34 ATOM 3855 CB VAL H 211 -4.688 2.416 49.299 1.0021.28 ATOM 3856 CGI VAL H 211 -4.837 2.986 50.708 1.00 25.89 ATOM 3857 CG2VAL H 211 -5.705 1.316 49.035 1.00 18.88 ATOM 3858 C VAL H211 -3.802 4.633 48.528 1.00 19.87 ATOM 3859 O VAL H211 -2.617 4.473 48.212 1.0020.58 ATOM 3860 N PRO H212 -4.201 5.771 49.134 1.00 21.21 ATOM 3861 CD PRO H 212 -5.573 6.115 49.582 1.00 18.81 ATOM 3862 CA PRO H 212 -3.258 6.886 49.422 1.00 20.72 ATOM 3863 CB PRO H212 -4.145 7.920 50.099 1.00 18.51 ATOM 3864 CG PRO H 212 -5.488 7.615 49.546 1.00 18.18 ATOM 3865 C PRO H 212 -2.124 6.456 50.338 1.00 23.63 ATOM 3866 O PRO H212 -2.326 5.576 51.182 1.0027.07 ATOM 3867 N ARG H 213 -0.926 7.043 50.151 1.0024.57 ATOM 3869 CA ARG H 213 0.187 6.766 51.053 1.0026.72 ATOM 3870 CB ARG H 213 1.569 6.813 50.343 1.0027.15 ATOM 3871 CG ARG H 213 1.860 7.978 49.396 1.00 33.85 ATOM 3872 CD ARG H 213 3.273 7.862 48.791 1.00 33.12 ATOM 3873 NE ARG H 213 3.507 6.520 48.248 1.0040.88 ATOM 3875 CZ ARG H 213 4.615 5.771 48.499 1.0040.65 ATOM 3876 NH1 ARG H 213 4.693 4.535 48.001 1.00 39.58 ATOM 3879 NH2 ARG H 213 5.649 6.260 49.206 1.00 37.54 ATOM 3882 C ARG H213 0.158 7.706 52.255 1.00 27.92 ATOM 3883 OTI ARG H 213 0.614 7.283 53.341 1.00 31.74 ATOM 3884 OT2 ARG H 213 -0.357 8.840 52.109 1.00 29.09 ATOM 3885 CB ALA P 2 31.237 -7.993 -6.254 1.00 23.82 ATOM 3886 C ALA P 2 29.863 -5.868 -6.170 1.00 18.78 ATOM 3887 O ALA P 2 29.809 -5.461 -5.015 1.00 18.94 ATOM 3890 N ALAP 2 32.338 -5.778 -6.117 1.0024.56 ATOM 3892 CA ALAP 2 31.159 -6.526 -6.677 1.0020.94 ATOM 3893 N ALA P 3 28.844 -5.788 -7.037 1.00 15.73 ATOM 3895 CA ALA P 3 27.600 -5.082 -6.736 1.00 14.42 ATOM 3896 CB ALA P 3 27.064 -4.460 -8.021 1.00 13.90 ATOM 3897 C ALA P 3 26.498 -5.955 -6.132 1.00 14.34 ATOM 3898 O ALA P 3 26.523 -7.202 -6.212 1.00 12.83 ATOM 3899 N PROP 4 25.531 -5.280 -5.471 1.00 12.41 ATOM 3900 CD PROP 4 25.569 -3.841 -5.120 1.00 10.70 ATOM 3901 CA PROP 4 24.365 -5.915 -4.878 1.00 9.09 ATOM 3902 CB PRO P 4 23.912 -4.871 -3.871 1.00 10.23 ATOM 3903 CG PRO P 4 24.158 -3.624 -4.622 1.00 10.28 ATOM 3904 C PROP 4 23.350 -6.158 -5.998 1.00 8.50 ATOM 3905 O PROP 4 23.720 -6.084 -7.147 1.00 12.29 ATOM 3906 N ASPP 5 22.110 -6.436 -5.707 1.00 3.44 ATOM 3908 CA ASP P 5 21.187 -6.699 -6.748 1.00 6.24 ATOM 3909 CB ASP P 5 19.976 -7.498 -6.231 1.00 4.87 WO 99/10379 PCT/GB98/02542 -269 ATOM 3910 CG ASP P 5 18.947 -7.830 -7.322 1.00 8.73 ATOM 3911 ODI ASP P 5 19.286 -7.812 -8.552 1.00 5.17 ATOM 3912 OD2 ASP P 5 17.787 -8.099 -6.971 1.00 6.00 ATOM 3913 C ASP P 5 20.734 -5.385 -7.386 1.00 11.49 ATOM 3914 O ASP P 5 19.876 -4.707 -6.867 1.00 13.66 ATOM 3915 N THRP 6 21.310 -5.045 -8.542 1.00 13.74 ATOM 3917 CA THRP 6 20.984 -3.797 -9.202 1.00 13.90 ATOM 3918 CB THRP 6 22.263 -3.137 -9.774 1.00 13.32 ATOM 3919 OGITHRP 6 22.896 -4.001 -10.731 1.00 19.82 ATOM 3921 CG2THRP 6 23.263 -2.884 -8.651 1.00 17.80 ATOM 3922 C THRP 6 19.944 -3.952 -10.296 1.00 13.91 ATOM 3923 O THRP 6 19.789 -3.050-11.122 1.00 16.59 ATOM 3924 N ARG P 7 19.213 -5.065 -10.338 1.00 12.22 ATOM 3926 CA ARGP 7 18.204 -5.190-11.372 1.00 12.33 ATOM 3927 CB ARG P 7 17.679 -6.625 -11.529 1.00 11.79 ATOM 3928 CG ARG P 7 16.416 -6.694 -12.378 1.00 14.75 ATOM 3929 CD ARG P 7 15.741 -8.045 -12.383 1.00 18.52 ATOM 3930 NE ARG P 7 16.521 -8.985 -13.132 1.0027.19 ATOM 3932 CZ ARGP 7 16.062 -9.667-14.164 1.0026.31 ATOM 3933 NH1 ARG P 7 16.877 -10.489 -14.780 1.00 31.37 ATOM 3936 NH2 ARG P 7 14.807 -9.547 -14.576 1.00 25.93 ATOM 3939 C ARGP 7 17.054 -4.242-11.085 1.00 15.83 ATOM 3940 O ARGP 7 16.730 -3.991 -9.908 1.00 15.84 ATOM 3941 N PROP 8 16.445 -3.636-12.151 1.00 15.86 ATOM 3942 CD PROP 8 16.848 -3.723 -13.596 1.00 15.67 ATOM 3943 CA PRO P 8 15.332 -2.725 -11.993 1.00 11.60 ATOM 3944 CB PROP 8 15.082 -2.163-13.418 1.00 16.26 ATOM 3945 CG PROP 8 16.398 -2.372-14.113 1.00 12.50 ATOM 3946 C PROP 8 14.099 -3.443 -11.426 1.00 15.08 ATOM 3947 O PROP 8 13.731 -4.578-11.824 1.00 7.39 ATOM 3948 N ALA P 9 13.513 -2.754 -10.452 1.00 14.65 ATOM 3950 CA ALA P 9 12.318 -3.174 -9.766 1.00 16.28 ATOM 3951 CB ALAP 9 12.035 -2.141 -8.639 1.00 13.79 ATOM 3952 C ALAP 9 11.143 -3.185-10.727 1.00 17.17 ATOM 3953 O ALAP 9 11.197 -2.526-11.760 1.00 19.75 ATOM 3954 N PROP 10 10.136 -4.011-10.481 1.00 17.47 ATOM 3955 CD PRO P 10 10.149 -5.176 -9.580 1.00 17.04 ATOM 3956 CA PRO P 10 8.950 -3.999-11.292 1.0020.33 ATOM 3957 CB PROP 10 8.088 -5.104 -10.680 1.00 14.66 ATOM 3958 CG PRO P 10 8.708 -5.384 -9.367 1.00 18.16 ATOM 3959 C PRO P 10 8.280 -2.585-11.246 1.0023.98 ATOM 3960 OTI PRO P 10 8.663 -1.761 -10.374 1.00 29.12 ATOM 3961 OT2 PRO P 10 7.407 -2.300 -12.100 1.00 32.81 ATOM 3962 OH2 WAT W 1 6.469 14.788 -4.498 1.00 14.28 ATOM 3965 OH2 WAT W 2 17.598 -23.808 -4.151 1.00 21.81 ATOM 3968 OH2 WAT W 3 18.632 4.032 58.157 1.00 6.32 ATOM 3971 OH2 WAT W 4 25.496 3.194 -6.045 1.00 13.58 ATOM 3974 OH2WATW 5 16.953 -5.194 -7.526 1.00 13.00 ATOM 3977 OH2 WAT W 6 24.903 -22.960 6.237 1.00 30.37 ATOM 3980 OH2 WAT W 7 21.593 -21.679 -1.338 1.00 3.40 ATOM 3983 OH2 WAT W 8 -3.000 -3.337 28.274 1.00 30.92 ATOM 3986 OH2 WAT W 9 29.010-11.559 3.896 1.00 9.44 ATOM 3989 OH2 WAT W 10 -2.022 11.290 49.065 1.00 32.00 ATOM 3992 OH2WATW 11 8.407-21.513 8.625 1.00 13.78 ATOM 3995 OH2 WAT W 12 13.728 27.079 30.459 1.00 39.32 ATOM 3998 OH2 WATW 13 3.495 4.636 44.813 1.00 13.19 WO 99/10379 PCT/GB98/02542 -270 ATOM 4001 OH2 WAT W 14 1.218 15.946 14.314 1.0022.53 ATOM 4004 OH2 WATW 15 12.903 -17.138 34.597 1.00 19.15 ATOM 4007 OH2 WAT W 16 10.898 -8.237 -12.633 1.00 21.26 ATOM 4010 OH2 WAT W 17 8.064 -14.542 21.148 1.00 37.92 ATOM 4013 OH2 WAT W 18 21.359 7.434 14.511 1.00 18.86 ATOM 4016 OH2 WAT W 19 -1.648 1.908 47.014 1.00 15.06 ATOM 4019 OH2 WAT W 20 16.737 9.406 27.272 1.00 14.21 ATOM 4022 OH2 WATW 21 20.693 12.449 -7.122 1.00 16.36 ATOM 4025 OH2 WAT W 22 7.885 -12.508 25.316 1.00 10.64 ATOM 4028 OH2 WAT W 23 -3.655 16.264 24.900 1.00 33.41 ATOM 4031 OH2 WATW 24 33.177 3.183 45.356 1.00 8.24 ATOM 4034 OH2 WAT W 25 -11.952 -7.879 37.114 1.0026.57 ATOM 4037 OH2 WAT W 26 25.803 12.531 -5.964 1.0021.74 ATOM 4040 OH2 WAT W 27 -2.656 4.045 26.085 1.00 17.07 ATOM 4043 OH2 WAT W 28 7.532 17.937 41.724 1.00 22.01 ATOM 4046 OH2 WAT W 29 23.879 -14.777 24.976 1.00 8.54 ATOM 4049 OH2 WAT W 30 31.338 -2.334 -1.810 1.00 19.31 ATOM 4052 OH2 WATW 31 17.502 7.886 16.158 1.0028.03 ATOM 4055 OH2 WAT W 32 5.941 -12.525 39.932 1.0020.30 ATOM 4058 OH2 WAT W 33 5.404 -1.056 17.882 1.0034.15 ATOM 4061 OH2 WATW 34 11.009-16.411 36.548 1.00 16.42 ATOM 4064 OH2WATW 35 6.478-14.860 -8.201 1.00 16.12 ATOM 4067 OH2 WAT W 36 9.172 0.986 -2.279 1.00 22.74 ATOM 4070 OH2 WAT W 37 4.511 -4.656 10.403 1.00 20.60 ATOM 4073 OH2 WAT W 38 20.413 -25.507 7.708 1.00 26.25 ATOM 4076 OH2 WATW 39 7.710 -2.607 1.725 1.00 13.86 ATOM 4079 OH2 WAT W 40 21.067 -25.174 -8.378 1.00 17.33 ATOM 4082 OH2 WAT W 41 14.047 -12.643 28.831 1.00 15.39 ATOM 4085 OH2 WAT W 42 24.985 -8.571 16.098 1.00 16.92 ATOM 4088 OH2 WAT W 43 18.061 -3.176 49.972 1.00 25.44 ATOM 4091 OH2 WAT W 44 8.725 -22.350 12.897 1.00 22.95 ATOM 4094 OH2 WAT W 45 12.305 -7.538 37.860 1.00 26.88 ATOM 4097 OH2 WAT W 46 3.222 -16.789 -4.360 1.00 19.56 ATOM 4100 OH2 WAT W 47 0.557 0.177 50.267 1.00 30.33 ATOM 4103 OH2 WAT W 48 19.082 -24.999 2.779 1.00 5.88 ATOM 4106 OH2 WAT W 49 19.857 5.737 -10.591 1.00 15.25 ATOM 4109 OH2 WAT W 50 27.548 -18.756 1.690 1.00 12.48 ATOM 4112 OH2WATW 51 18.386 -0.621 -10.504 1.0026.95 ATOM 4115 OH2 WAT W 52 14.332-24.453 3.096 1.0021.65 ATOM 4118 OH2WATW 53 15.420-11.836 25.521 1.00 19.62 ATOM 4121 OH2 WATW 54 7.048 -3.604 7.452 1.00 10.22 ATOM 4124 OH2 WAT W 55 8.771 -20.550 29.022 1.0024.86 ATOM 4127 OH2 WAT W 56 7.223 14.260 47.625 1.00 38.64 ATOM 4130 OH2 WATW 57 28.000-19.890 -6.750 1.00 5.62 ATOM 4133 OH2 WAT W 58 25.854 -19.568 7.742 1.00 10.53 ATOM 4136 OH2 WAT W 59 21.053 -23.375 -10.438 1.00 13.82 ATOM 4139 OH2 WAT W 60 27.634 -1.672 12.546 1.00 16.07 ATOM 4142 OH2 WATW 61 4.320 -13.192 12.140 1.00 29.58 ATOM 4145 OH2 WAT W 62 10.805 -25.481 15.446 1.00 30.70 ATOM 4148 OH2 WAT W 63 16.133 5.455 14.708 1.00 33.54 ATOM 4151 OH2 WAT W 64 18.557 -2.351 28.596 1.0029.04 ATOM 4154 OH2WATW 65 11.919 1.172 24.227 1.0027.66 ATOM 4157 OH2 WATW 66 20.602 0.152 12.952 1.00 13.20 ATOM 4160 OH2 WAT W 67 2.523 2.197 48.994 1.00 25.99 ATOM 4163 OH2 WATW 68 18.370 -9.737 -9.821 1.00 8.99 ATOM 4166 OH2 WAT W 69 12.339 -2.363 38.736 1.00 18.95 WO 99/10379 PCT/GB98/02542 -271 ATOM 4169 OH2 WATW 70 28.531 -9.198 -6.241 1.00 15.87 ATOM 4172 OH2 WAT W 71 7.113 2.252 42.134 1.0024.77 ATOM 4175 OH2WATW 72 5.551 -6.218 1.097 1.0025.37 ATOM 4178 OH2WATW 73 27.031 -2.271 -10.652 1.00 35.24 ATOM 4181 OH2 WATW 74 23.700 -4.680 9.160 1.00 10.39 ATOM 4184 OH2 WAT W 75 21.927 -8.069 -10.281 1.00 19.23 ATOM 4187 OH2WATW 76 9.255 21.329 27.676 1.0022.97 ATOM 4190 OH2 WAT W 77 -1.050 9.080 47.795 1.00 17.17 ATOM 4193 OH2 WATW 78 23.569 -2.863 10.958 1.00 11.39 ATOM 4196 OH2 WAT W 79 14.936 -18.091 -13.265 1.00 38.75 ATOM 4199 OH2 WATW 80 18.885 -22.021 -1.608 1.00 16.43 ATOM 4202 OH2 WATW 81 6.214 9.528 3.424 1.00 10.35 ATOM 4205 OH2WATW 82 8.852 -8.980 40.128 1.00 19.41 ATOM 4208 OH2 WAT W 83 13.989 26.590 5.643 1.00 30.50 ATOM 4211 OH2WATW 84 14.832 15.962 -3.151 1.00 14.73 ATOM 4214 OH2 WAT W 85 22.345 -12.016 -10.082 1.00 12.02 ATOM 4217 OH2 WAT W 86 11.978 -24.989 2.736 1.00 17.04 ATOM 4220 OH2 WAT W 87 14.518 -25.660 19.374 1.00 12.97 ATOM 4223 OH2 WATW 88 26.181 0.882 12.155 1.00 14.84 ATOM 4226 OH2 WAT W 89 3.965 18.045 34.071 1.00 14.92 ATOM 4229 OH2WATW 90 2.944-12.722 -0.100 1.0030.35 ATOM 4232 OH2WATW 91 21.018 -0.090 -7.931 1.00 11.45 ATOM 4235 OH2 WAT W 92 17.704 4.172 55.338 1.00 23.03 ATOM 4238 OH2 WAT W 93 30.887-19.001 0.180 1.00 18.12 ATOM 4241 OH2WATW 94 8.090 0.598-12.040 1.0035.87 ATOM 4244 OH2 WAT W 95 -0.137 11.808 40.511 1.00 19.09 ATOM 4247 OH2 WAT W 96 25.436 11.667 49.096 1.00 39.93 ATOM 4250 OH2 WATW 97 13.418 9.927 61.190 1.00 17.48 ATOM 4253 OH2 WAT W 98 31.648 7.847 -5.602 1.00 19.58 ATOM 4256 OH2 WATW 99 15.243 0.341 35.899 1.00 11.83 ATOM 4259 OH2 WAT W 100 -5.216-15.339 38.926 1.00 16.58 ATOM 4262 OH2 WAT W 101 1.803 -1.527 48.192 1.00 29.29 ATOM 4265 OH2 WAT W 102 -9.962 4.701 47.615 1.00 27.17 ATOM 4268 OH2 WATW 103 6.926 1.104 30.511 1.0021.69 ATOM 4271 OH2 WAT W 104 20.040 0.675 43.899 1.00 28.97 ATOM 4274 OH2 WAT W 105 6.476 6.252 15.949 1.00 21.65 ATOM 4277 OH2 WAT W 106 13.134 23.738 -4.232 1.00 9.47 ATOM 4280 OH2 WAT W 107 -9.097 -5.473 44.708 1.00 32.78 ATOM 4283 OH2 WAT W 108 29.597 -16.402 0.794 1.00 23.02 ATOM 4286 OH2 WAT W 109 1.393 12.084 -0.555 1.00 27.33 ATOM 4289 OH2WATW 110 32.275 10.498 -1.711 1.0022.13 ATOM 4292 OH2 WAT W 111 28.840 -8.588 8.722 1.00 16.73 ATOM 4295 OH2 WATW 112 24.301 5.966-10.135 1.0017.97 ATOM 4298 OH2 WAT W 113 13.047 -12.047 26.295 1.00 17.02 ATOM 4301 OH2 WAT W 114 23.665 -12.540 16.941 1.00 18.85 ATOM 4304 OH2 WAT W 115 28.346 2.252 -10.297 1.00 57.76 ATOM 4307 OH2 WAT W 116 16.579 -26.334 6.701 1.00 14.43 ATOM 4310 OH2WATW 117 25.807 11.294 9.613 1.0020.54 ATOM 4313 OH2 WAT W 118 32.494 10.036 -4.577 1.0028.60 ATOM 4316 OH2 WATW 119 32.460 4.112 -6.893 1.0045.04 ATOM 4319 OH2WATW 120 -11.721 12.136 46.764 1.0024.53 ATOM 4322 OH2 WAT W 121 2.092 -13.612 -7.710 1.00 34.84 ATOM 4325 OH2 WAT W 122 5.719 -8.608 46.184 1.00 13.18 ATOM 4328 OH2WATW 123 15.576 -9.029 24.115 1.00 30.63 ATOM 4331 OH2WATW 124 27.668-17.190 14.414 1.00 14.55 ATOM 4334 OH2 WAT W 125 -17.404 6.631 48.404 1.00 17.20 WO 99/10379 PCT/GB98/02542 -272 ATOM 4337 OH2 WAT W 126 23.431 -13.579 22.761 1.00 26.67 ATOM 4340 OH2 WAT W 127 17.744 1.470 26.979 1.00 47.02 ATOM 4343 OH2 WAT W 128 14.051 5.680 21.680 1.0023.91 ATOM 4346 OH2 WAT W 129 -9.668 0.532 31.275 1.00 16.36 ATOM 4349 OH2WATW 130 5.213 -6.655 -15.383 1.0038.16 ATOM 4352 OH2WAT W 131 31.931 8.541 5.215 1.00 13.75 ATOM 4355 OH2 WAT W 132 14.297 -2.797 27.765 1.00 27.48 ATOM 4358 OH2 WAT W 133 34.060 -3.373 1.190 1.0028.35 ATOM 4361 OH2 WAT W 134 8.266 -8.418-11.712 1.00 16.01 ATOM 4364 OH2 WAT W 135 21.210 -24.747 25.495 1.00 21.80 ATOM 4367 OH2 WAT W 136 38.415 7.827 2.261 1.00 18.43 ATOM 4370 OH2 WATW 137 7.104 11.613 49.567 1.00 16.91 ATOM 4373 OH2 WAT W 138 22.354 8.172 -1.094 1.00 3.60 ATOM 4376 OH2 WAT W 139 -0.649 13.876 38.964 1.00 53.27 ATOM 4379 OH2 WAT W 140 3.532 20.509 33.354 1.00 25.23 ATOM 4382 OH2 WAT W 141 26.020 -21.708 3.681 1.00 8.89 ATOM 4385 OH2 WAT W 142 16.768 19.739 12.715 1.00 12.58 ATOM 4388 OH2 WAT W 143 22.933 1.122 -9.255 1.00 33.61 ATOM 4391 OH2 WAT W 144 13.952 -25.966 12.995 1.00 18.24 ATOM 4394 OH2WATW 145 -1.798-13.563 5.388 1.0022.46 ATOM 4397 OH2 WAT W 146 31.947 -3.239 6.296 1.0021.74 ATOM 4400 OH2 WAT W 147 -4.303 -0.614 28.886 1.00 26.69 ATOM 4403 OH2 WAT W 148 21.134-26.915 23.907 1.00 16.34 ATOM 4406 OH2 WAT W 149 21.965 7.892 -11.778 1.00 26.06 ATOM 4409 OH2 WAT W 150 10.626 -24.261 12.603 1.00 21.28 ATOM 4412 OH2 WAT W 151 4.596 13.855 -6.210 1.00 7.70 ATOM 4415 OH2 WAT W 152 30.277 6.152 11.049 1.00 16.94 ATOM 4418 OH2 WAT W 153 24.985 -7.067 9.817 1.00 17.58 ATOM 4421 OH2 WAT W 154 11.329 -3.862 36.792 1.00 23.50 ATOM 4424 OH2 WAT W 155 -15.325 3.494 41.706 1.00 35.32 ATOM 4427 OH2 WAT W 156 15.210-24.587 -4.662 1.00 18.53 ATOM 4430 OH2 WAT W 157 1.420 -5.547 7.576 1.00 23.51 ATOM 4433 OH2 WATW 158 -11.870 17.085 41.012 1.00 30.42 ATOM 4436 OH2 WAT W 159 6.864 -18.801 28.608 1.00 19.33 ATOM 4439 OH2 WAT W 160 12.992 -0.675 26.187 1.0021.36 ATOM 4442 OH2 WAT W 161 33.462 -5.652 6.209 1.00 23.60 ATOM 4445 OH2 WAT W 162 13.931 24.641 31.377 1.00 36.78 ATOM 4448 OH2 WAT W 163 1.149 -14.946 26.149 1.00 29.62 ATOM 4451 OH2 WAT W 164 24.449 -8.330 -9.652 1.00 15.70 ATOM 4454 OH2 WAT W 165 3.122 11.598 42.075 1.0020.46 ATOM 4457 OH2 WAT W 166 10.713 22.846 -4.457 1.00 13.45 ATOM 4460 OH2 WAT W 167 -6.701 -5.190 46.412 1.0031.64 ATOM 4463 OH2 WAT W 168 5.589 -4.185 17.993 1.00 32.66 ATOM 4466 OH2 WAT W 169 -20.269 5.845 45.392 1.00 11.80 ATOM 4469 OH2 WAT W 170 18.348 -6.708 -2.520 1.00 3.86 ATOM 4472 OH2 WAT W 171 29.246-15.130 3.788 1.00 14.16 ATOM 4475 OH2 WAT W 172 15.259 12.226 54.789 1.00 37.54 ATOM 4478 OH2 WAT W 173 17.143 -24.993 -9.493 1.00 35.04 ATOM 4481 OH2 WAT W 174 8.818 -1.363 19.163 1.0036.48 ATOM 4484 OH2 WAT W 175 32.233 -8.889 4.729 1.00 19.69 ATOM 4487 OH2 WATW 176 28.467-17.015 -2.185 1.00 5.68 ATOM 4490 OH2 WATW 177 6.024 25.034 11.136 1.0022.81 ATOM 4493 OH2 WAT W 178 20.243 3.145 40.487 1.0023.82 ATOM 4496 OH2 WAT W 179 -0.519 -13.612 40.661 1.00 30.50 ATOM 4499 OH2 WAT W 180 34.547 -2.642 5.862 1.0021.60 ATOM 4502 OH2 WAT W 181 7.161 4.607 25.463 1.00 15.09 WO 99/10379 PCT/GB98/02542 -273 ATOM 4505 OH2 WAT W 182 -4.704 11.611 31.080 1.0020.86 ATOM 4508 OH2 WATW 183 21.433 -23.454 9.547 1.00 31.82 ATOM 4511 OH2 WAT W 184 13.857 17.680 46.003 1.0021.96 ATOM 4514 OH2 WAT W 185 17.187 -16.883 -12.460 1.00 20.68 ATOM 4517 OH2 WAT W 186 19.746 -21.300 -14.638 1.00 27.48 ATOM 4520 OH2 WAT W 187 12.148 14.642 15.368 1.00 19.96 ATOM 4523 OH2 WAT W 188 5.387 -6.500 -12.696 1.00 35.66 ATOM 4526 OH2 WATW 189 4.586 13.697 39.870 1.00 20.33 ATOM 4529 OH2 WAT W 190 21.769 5.215 41.762 1.00 36.13 ATOM 4532 OH2WATW 191 29.219-21.787 7.401 1.0020.15 ATOM 4535 OH2 WAT W 192 17.974 -9.978 24.596 1.00 36.15 ATOM 4538 OH2 WAT W 193 12.473 -28.071 4.359 1.00 18.19 ATOM 4541 OH2WATW 194 13.012 10.112 21.862 1.0038.97 ATOM 4544 OH2 WAT W 195 25.597 8.673 49.783 1.00 27.52 ATOM 4547 OH2 WAT W 196 24.837 10.769 46.030 1.00 10.14 ATOM 4550 OH2 WAT W 197 27.972 -17.140 -7.933 1.00 47.72 ATOM 4553 OH2 WAT W 198 26.863 3.704 48.558 1.00 27.25 ATOM 4556 OH2 WATW 199 15.918 0.432 -1.511 1.00 13.61 ATOM 4559 OH2 WAT W 200 5.655 -3.768 25.280 1.00 30.04 ATOM 4562 OH2 WAT W 201 23.425 6.240 13.624 1.00 11.98 ATOM 4565 OH2 WAT W 202 4.290 5.208 17.451 1.0021.77 ATOM 4568 OH2 WAT W 203 0.290 -9.212 42.200 1.00 15.59 ATOM 4571 OH2 WAT W 204 25.007 2.912 -8.754 1.00 19.57 ATOM 4574 OH2 WAT W 205 20.205 1.110 -9.843 1.00 34.32 ATOM 4577 OH2 WAT W 206 -3.217 8.862 32.830 1.00 6.08 ATOM 4580 OH2 WAT W 207 16.144-17.034 -8.816 1.00 22.31 ATOM 4583 OH2 WAT W 208 19.175 8.807 -10.884 1.0042.96 ATOM 4586 OH2 WAT W 209 1.655 -6.944 45.357 1.0037.43 ATOM 4589 OH2WATW210 -8.549 4.472 49.787 1.0025.82 ATOM 4592 OH2WAT W 211 3.867 -7.430 27.878 1.0027.19 ATOM 4595 OH2 WAT W 212 23.654 -2.619 -13.589 1.00 28.44 ATOM 4598 OH2WAT W 213 29.110 12.286 -6.363 1.0038.04 ATOM 4601 OH2 WAT W 214 23.926-20.838 2.405 1.00 5.04 ATOM 4604 OH2WAT W 215 27.197 3.738 37.195 1.0024.05 ATOM 4607 OH2WAT W 216 5.195-12.115 14.877 1.00 13.79 ATOM 4610 OH2 WAT W 217 7.487 4.063 14.308 1.0026.14 ATOM 4613 OH2 WAT W 218 20.375 10.379 8.335 1.00 2.00 ATOM 4616 OH2WAT W 219 17.302 -1.823 -8.469 1.00 18.45 ATOM 4619 OH2 WAT W220 6.804 18.384 -1.961 1.00 18.17 ATOM 4622 OH2 WAT W 221 30.521 -17.401 -8.988 1.00 9.31 ATOM 4625 OH2WAT W 222 1.118-13.903 28.627 1.0022.20 ATOM 4628 OH2 WAT W 223 4.658 4.612 24.950 1.00 14.99 ATOM 4631 OH2 WAT W 224 0.009 17.440 18.293 1.0024.15 ATOM 4634 OH2 WAT W 225 9.924 -27.510 -4.500 1.00 24.23 ATOM 4637 OH2 WAT W 226 17.922 7.851 29.078 1.00 26.71 ATOM 4640 OH2WAT W 227 26.329 5.158 -2.190 1.00 7.58 ATOM 4643 OH2 WAT W 228 16.212 -0.659 25.988 1.00 51.29 ATOM 4646 OH2 WAT W 229 8.255 -11.625 39.145 1.00 24.13 ATOM 4649 OH2 WAT W 230 -0.739 11.893 32.356 1.00 14.96 ATOM 4652 OH2 WAT W 231 10.244 -6.616 43.601 1.0027.57 ATOM 4655 OH2 WAT W232 0.924 9.055 32.613 1.00 24.54 ATOM 4658 OH2 WAT W 233 2.598 11.742 32.894 1.00 21.65 ATOM 4661 OH2WAT W 234 6.719 -0.044 43.519 1.00 10.20 ATOM 4664 OH2 WAT W 235 18.217 -24.604 5.251 1.00 11.95 ATOM 4667 OH2 WAT W 236 8.252 6.201 12.463 1.0021.41 ATOM 4670 OH2 WAT W 237 23.441 13.635 49.710 1.00 30.08 WO 99/10379 PCT/GB98/02542 -274 ATOM 4673 OH2 WAT W 238 17.020 -7.750 -4.400 1.00 15.78 ATOM 4676 OH2 WAT W 239 30.779 -10.002 6.550 1.00 27.21 ATOM 4679 OH2 WAT W 240 -6.748 -6.499 32.312 1.0029.81 ATOM 4682 OH2 WAT W 241 16.503 -12.922 28.084 1.00 36.06 ATOM 4685 OH2 WAT W 242 12.122 -24.490 -7.899 1.00 19.39 ATOM 4688 OH2 WAT W 243 21.099 12.849 35.212 1.00 24.60 ATOM 4691 OH2 WAT W 244 18.243 -8.436 20.387 1.0023.62 ATOM 4694 OH2 WAT W 245 20.147 10.002 34.434 1.00 11.86 ATOM 4697 OH2 WAT W 246 29.723 9.471 -8.340 1.00 34.43 ATOM 4700 OH2 WAT W 247 13.252 2.121 14.964 1.0024.74 ATOM 4703 OH2 WAT W 248 23.464 -25.374 4.258 1.00 13.44 ATOM 4706 OH2 WAT W 249 14.000 -22.772 -6.620 1.00 17.30 ATOM 4709 OH2 WAT W 250 10.326 0.557 16.215 1.0041.70 ATOM 4712 OH2 WAT W 251 13.521 2.393 -9.514 1.0020.28 ATOM 4715 OH2WAT W 252 13.615 -26.397 -3.875 1.00 15.20 ATOM 4718 OH2 WAT W 253 24.833 10.111 -7.130 1.0029.35 ATOM 4721 OH2 WAT W 254 13.064 -15.952 -13.595 1.00 26.25 ATOM 4724 OH2 WAT W 255 -15.057 5.686 39.924 1.0039.38 ATOM 4727 OH2 WAT W 256 16.336 15.971 31.027 1.00 19.01 ATOM 4730 OH2 WAT W 257 12.624 -9.192 43.712 1.0020.05 ATOM 4733 OH2 WAT W 258 12.967 -8.262 23.940 1.00 41.00 ATOM 4736 OH2 WAT W 259 14.757 0.585 -10.768 1.00 28.58 ATOM 4739 OH2WAT W 260 19.819 -1.817-13.475 1.0035.11 ATOM 4742 OH2 WAT W 261 31.389-15.656 -0.825 1.0026.24 ATOM 4745 OH2 WAT W 262 14.395 -13.087 -16.099 1.00 16.37 ATOM 4748 OH2 WAT W 263 22.719 13.037 16.198 1.00 21.47 ATOM 4751 OH2WAT W 264 16.540 21.557 39.053 1.0026.03 ATOM 4754 OH2 WAT W 265 -6.562 -9.693 42.850 1.00 26.79 ATOM 4757 OH2 WAT W 266 32.765 6.771 -7.894 1.0026.76 ATOM 4760 OH2 WAT W 267 7.895 14.072 16.472 1.00 18.53 ATOM 4763 OH2WAT W 268 35.614 1.144 10.445 1.0031.99 ATOM 4766 OH2 WAT W 269 13.248 -7.824 41.224 1.0027.81 ATOM 4769 OH2 WAT W 270 26.612 -16.221 -10.354 1.00 24.35 ATOM 4772 OH2 WAT W 271 9.404 21.743 36.231 1.0026.21 ATOM 4775 OH2 WAT W 272 2.135 -1.886 26.621 1.00 19.18 ATOM 4778 OH2 WAT W 273 5.029 -16.489 24.250 1.00 21.38 ATOM 4781 OH2 WAT W 274 -3.689 11.484 26.196 1.00 32.16 ATOM 4784 OH2 WAT W 275 -0.444 20.210 19.609 1.00 28.61 ATOM 4787 OH2WAT W 276 20.202 13.824 -1.393 1.00 6.13 ATOM 4790 OH2WAT W 277 8.008 8.335 14.152 1.0026.36 ATOM 4793 OH2 WAT W 278 -0.089 -4.167 27.283 1.0022.58 ATOM 4796 OH2 WAT W 279 6.446 -12.379 22.877 1.00 39.32 ATOM 4799 OH2 WAT W 280 27.976 -9.405 11.870 1.0021.31 ATOM 4802 OH2WAT W 281 18.063 -5.600 47.215 1.0028.13 ATOM 4805 OH2 WAT W 282 27.726 -20.314 5.883 1.00 29.05 ATOM 4808 OH2WAT W 283 7.306 3.337 5.457 1.00 15.35 ATOM 4811 OH2WAT W 284 -1.946 14.609 1.577 1.0030.36 ATOM 4814 OH2WAT W 285 11.677 -3.115 17.818 1.00 19.72 ATOM 4817 OH2WAT W 286 21.862-21.678 1.194 1.0014.10 ATOM 4820 OH2 WAT W 287 21.062 -6.560 -2.887 1.00 10.76 ATOM 4823 OH2WAT W 288 15.270 0.156 17.566 1.0023.02 ATOM 4826 OH2WAT W 289 17.300 -6.730 54.194 1.0023.81 ATOM 4829 OH2WAT W 290 22.196-16.787 24.840 1.0026.10 ATOM 4832 OH2 WAT W 291 11.450 -1.461 -14.210 1.00 17.37 ATOM 4835 OH2WAT W 292 9.545 1.106 23.451 1.00 18.75 ATOM 4838 OH2 WAT W 293 13.359 17.520 21.914 1.00 32.59 WO 99/10379 PCT/GB98/02542 -275 ATOM 4841 OH2 WAT W 294 26.885 -7.151 7.996 1.00 19.34 ATOM 4844 OH2 WAT W 295 21.756 -13.103 -13.701 1.00 29.49 ATOM 4847 OH2WAT W 296 11.457 -7.218 35.141 1.0022.34 ATOM 4850 OH2 WAT W 297 18.708 0.544 -7.701 1.00 16.39 ATOM 4853 OH2 WAT W 298 -15.953 3.350 44.816 1.0037.24 ATOM 4856 OH2 WAT W 299 8.407 -8.314 42.681 1.0028.38 ATOM 4859 OH2 WAT W 300 2.540 -9.294 23.041 1.0035.16 ATOM 4862 OH2 WAT W 301 22.018 -7.958 -0.799 1.00 6.11 ATOM 4865 OH2 WAT W 302 21.966 -24.488 2.085 1.00 8.66 ATOM 4868 OH2 WAT W 303 20.076 -25.315 17.635 1.00 9.01 ATOM 4871 OH2 WAT W 304 17.006 -22.056 5.026 1.00 5.97 ATOM 4874 OH2 WAT W 305 6.060 -7.502 14.185 1.0041.33 ATOM 4877 OH2 WAT W 306 32.819 -13.271 -1.536 1.00 7.51 ATOM 4880 OH2 WAT W 307 -7.134 13.283 28.131 1.00 26.60 ATOM 4883 OH2 WAT W 308 6.093 -19.675 20.689 1.00 34.63 ATOM 4886 OH2 WAT W 309 5.245 8.997 12.387 1.00 19.78 ATOM 4889 OH2 WAT W 310 12.019 2.613 52.929 1.0021.69 ATOM 4892 OH2 WAT W 311 10.010 19.928 41.543 1.00 33.05 ATOM 4895 OH2 WAT W 312 13.142 -23.671 -10.200 1.00 36.76 ATOM 4898 OH2 WAT W 313 8.670 -24.177 7.948 1.0034.91 ATOM 4901 OH2WAT W 314 29.062 -9.848 -3.498 1.0029.41 ATOM 4904 OH2 WAT W 315 14.807 -9.227 46.355 1.00 40.86 ATOM 4907 OH2WAT W 316 7.251 26.098 3.963 1.0028.36 ATOM 4910 OH2WAT W 317 23.961 5.881 39.286 1.0021.45 ATOM 4913 OH2 WAT W 318 8.771 7.324 16.718 1.0036.71 ATOM 4916 OH2WAT W 319 -1.090 -7.807 23.575 1.0040.27 ATOM 4919 OH2WAT W 320 22.689 2.991 44.255 1.0031.90 ATOM 4922 OH2WAT W 321 11.210 -9.771 22.151 1.0038.45 ATOM 4925 OH2WAT W 322 22.311 0.357-12.113 1.0023.98 ATOM 4928 OH2 WAT W 323 6.735 14.216 -9.674 1.00 45.55 ATOM 4931 OH2 WAT W 324 -8.071 -4.209 27.927 1.0029.83 ATOM 4934 OH2WAT W 325 1.445 17.951 34.713 1.0030.61 ATOM 4937 OH2 WAT W 326 19.684 9.965 25.552 1.0033.30 ATOM 4940 OH2WAT W 327 2.120 14.444 12.302 1.0037.11 ATOM 4943 OH2WAT W 328 15.167 -4.201 25.183 1.0029.17 ATOM 4946 OH2 WAT W 329 12.976 28.071 24.361 1.00 30.90 ATOM 4949 OH2WAT W 330 1.965 -6.101 27.052 1.00 18.90 ATOM 4952 OH2WAT W 331 20.107 17.468 33.762 1.0041.90 ATOM 4955 CD HET I 1 -3.687 11.892 28.658 1.00 34.52 ATOM 4956 CD HET I 2 7.014 -2.547 18.557 1.0056.55 ATOM 4957 CD HETI 3 -18.910 6.317 46.958 1.0025.08 ATOM 4958 CD HETI 4 31.181 -13.966 -2.383 1.00 17.70 ATOM 4959 CD HET I 5 7.075 -7.626 -14.342 1.00 57.21 ATOM 4960 CD HET I 6 9.353 21.680 25.019 0.7548.85 ATOM 4961 CD HET I 7 22.069 5.816 -10.264 0.7526.79 ATOM 4962 CD HET I 8 17.818 -0.561 27.627 0.7556.40 ATOM 4963 CL CHL I 9 -19.039 3.937 48.052 1.0022.14 ATOM 4964CL CHLI 10 30.927-12.252 -4.117 1.0026.88 WO99/10379 PCT/GB98/02542 -276 Table 3 Data statistics of SM3 Fab fragment/MUC1 epitope crystal 5 D(A) No. of Completeness Multiplicity Average observed of data (%) I/a(I) reflections in shell 6.06 1125 96.2 3.5 15.7 4.33 1994 98.8 3.6 14.7 3.54 2428 96.1 3.4 13.1 3.07 2985 98.1 3.5 10.8 10 2.75 3374 98.0 3.5 10.9 2.51 3718 98.0 3.5 8.0 2.33 3965 96.3 3.4 7.0 2.18 4299 97.3 3.1 3.4 2.06 4528 96.4 3.3 3.6 15 1.95 4623 93.2 3.2 3.1 Total 33093 96.6 3.4 8.1 D is the resolution defined as the interplanar spacings d=lambda/2 sintheta corresponding to the maximum observed 20 2theta values where lambda=1.54 angstroms. 2theta refers to the angle of diffraction. Lower resolutions have. higher nos and higher resolutions have lower nos. .I=intensity and sig(i) gives the standard deviation of the intensity for each batch of reflections. This 25 indicates how well measured the data is. Higher values means stronger more intense data lower values mean the data is weakly measured. Note this value drops off as the resolution becomes higher, for example at 1.95 A the angle of diffraction is quite great.

WO 99/10379 PCT/GB98/02542 -277 Table 4 Summary of the refinement statistics for the SM3-EP1 structure. Statistics for Table 2a Resolution range 8.0 - 1.95 A No. of residues 434 Missing residues 16 No. of protein atoms 3193 No. of solvent atoms 335 No. of metal atoms 8 No. of reflections with I > 2.5 o(I) (all data) 32197 (27688) Space group P 2 1 Cell dimensions a=42.

2 ; b=83.7; c=6 7

.

2 A, f6= 93.30 R with I > 2.5 o(I) 20.7% R free with I > 2.5 o(I) 27.9 % Average B-factor (Fab, antigen, all atoms) 15.6 A 2, 15.4 A , 16.4 A 2 Rmsd on bond distances 0.017 A Rmsd on bond angles 1.6040 Rmsd on impropers 1.3570 Statistics for Table 2b Resolution range 8.0 - 1.95 A No. of residues 434 Missing residues 16 No. of protein atoms 3227 No. of solvent atoms 331 No. of metal atoms 8 No. of reflections with F > 4 s(F) (all data) 32197 (28735) Completness with F > 4 s(F) (all data) 85.6% (96.0%) Space group P 21 Cell dimensions a=42.2; b=83.7; c=67.2 A, 6= 93.30 R with F > 4s(F) (all data) 21.3 % (23.8%) R free with F > 4s(F) (all data) 28.3 % (30.1 %) Average B-factor (Fab, antigen, all atoms) 15.6 A 2, 15.4 A 2, 16.4 A 2 Rmsd on bond distances 0.017A Rmsd on bond angles 1.6040 Rmsd on impropers 1.3570 WO 99/10379 PCT/GB98/02542 -278 Table 5 Antigen - antibody contacts Residues involved in cis-peptide bond are underlined; SAS - solvent accessible surface of peptide residue; Residue no. 2 is Ser, but was modelled as Ala. Peptide residue % of SAS number Fab residues Location buried of contacts in structure AIa2P 31.6 6 Trp91L, Ser93L L3 (Ser) 7 waters AIa3P 52.0 8 Tyr32L, Trp91L, Trp33H L1, L3, H1 5 waters Pro4P 94.4 17 Tyr32L, Trp91L, Trp96L L1, L3 8 Trp33H, GIn97H H1, H3 2 waters 1 Thr6P antigen Asp5P 89.3 24 Tyr32H, Trp33H HI1 4 GIn97H H3 16 waters 1 Arg7P antigen Thr6P 23.6 1 Tyr32L L1 11 waters Arg7P 46.9 12 Asn31H, Tyr32H H1 11 waters Pro8P 7.9 5 Tyr32H H1 5 waters AIa9P 60.8 7 Pro56L, Tyr32H, Va195H L2, H1, H3 5 waters ProlOP 48.7 7 Pro56L, Phe27H, Tyr32H L2, HI 2 TyrI02H H3 5 waters WO 99/10379 PCT/GB98/02542 -279 Table 6. Nucleotide and amino acid sequences of the light and heavy variable chains of SM3. The numbering in this table is for convenience only and does not correspond to the conventional numbering of these sequences. Light Chain Variable Region GAT ATC GTT GTG ACT CAG GAA TCT GCA CTC ACC ACA TCA CCT GGT GAA 48 Asp Ile Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 1 5 10 15 ACA GTC ACA CTC ACT TGT CGC TCA AGT ACT GGG GCT GITT ACA ACT AGT 96 Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 20 25 30 AAC TAT GCC AAC TGG GTC CAA GAA AAA CCA GAT CAT TTA TTC ACT GGT 144 Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 35 40 45 CTA ATA GGT GGT ACC AAC AAC CGA GCA CCA GGT GITT CCT GCC AGA TTC 192 Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 50 55 60 TCA GGC TCC CTG ATT GGA GAC AAG GCT GCC CTC ACC ATC ACA GGG GCA 240 Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 65 70 75 80 CAG ACT GAG GAT GAG GCA ATA TAT TTIC TGT GCT CTA TGG TAC AGC AAC 288 Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 85 90 95 CAT TGG GTG TTC GGT GGA GGA ACC AAA CTG ACT GTC CTA GGA TCC GAG 336 His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Glu 100 105 110 Heavy Chain Variable Region CAA GTT CAG CTG CAG GAG TCT GGA GGA GGC TTG GTG CAA CCT GGA GGA 48 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 115 120 125 TCC ATG AAA CTC TCC TGT GITT GCC TCT GGA TTC ACT TTC AGT AAC TAC 96 Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 130 135 140 WO 99/10379 PCT/GB98/02542 -280 TGG ATG AAC TGG GTC CGC CAG TCT CCA GAG AAG GGG CTT GAG TGG GTT 144 Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 145 150 155 160 GCT GAA ATT AGA TTG AAA TCT AAT AAT TAT GCA ACA CAT TAT GCG GAG 192 Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 165 170 175 TCT GTG AAA GGG AGG TTC ACC ATC TCA AGA GAT GAT TCC AAA AGT AGT 240 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 180 185 190 GTC TAC CTG CAA ATG AAC AAC TTA AGA GCT GAA GAC ACT GGC ATT TAT 288 Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 195 200 205 TAC TGT ACG GGA GTG GGA CAG TTT GCT TAC TGG GGC CAA GGG ACC ACG 336 Tyr Cys Thr Gly Val Gly Gln Phe Ala Tyr Trp Gly Gln Gly Thr Thr 210 215 220 GTC ACC GTC TCC TC 350 Val Thr Val Ser 225 WO 99/10379 PCT/GB98/02542 -281 Table 7 Phi (4) and psi (y) dihedral angles for the bound MUC1 peptide antigen. Residue 4 (o) o (0) Ala 2P ---- 141 Ala 3P -92 160 Pro 4P -81 -165 Asp 5P -78 101 Thr 6P -97 16 Arg 7P -71 143 Pro 8P -65 135 Ala 9P -66 153 Pro 10P -59 ---- WO 99/10379 PCT/GB98/02542 -282 Table 8 SM3 - MUC1 van der Waals (vdW) contacts and hydrogen bonds (HB; direct and mediated through water). Residues involved in the cis -peptide bond are underlined. Ser2P was modelled as Ala. Distance cut-off used: 4.0A for vdW contacts, 4.OA for direct HBs (weak HB above 3.5A are marked with an asterisk) and 3.5A for water mediated HBs. MC and SC refer to the main chain and side chain atoms of the SM3 antibody, respectively. Peptide number of Fab residues CDR Hydrogen bond Distance (A) residue vdW contacts peptide - Fab MC SC Ser2P 1 4 W9L, S93L L3 O - N l (W91L) 2.63 (Ala) O - O (S 9 3 L) 3.46 Ala3P 5 y3 2 L L1 4 W1 L L3 1 W 33H HI

RS

2 H H2 O - water - Nil (RS 2 H) 2.90, 2.98 Pro4P 10 Y 3 M L1 6 W9IL, W96L L3 N - Nel (W9IL) 3.88" 6 w33H Hi 2 Q H3 Asp5P 3 19 Y 32 H, W33H H1 081 - Nel (W 3 3 H) 3.89" HI 082 - N (W 3 3 ) 3.18 HI 082 - water - O (W 3 ") 2.71, 2.78

N

3

"

H H1 081 - water- O (N 3 1 ") 2.48, 2.66 H1 082 - water - O (N 3m ) 3.35, 2.66 3 QH H3 O- Ne2(Q~) 3.01

V

9 H H3 082 - water - N (V 9 '") 2.71, 2.89 H3 082 - water - N (Q!2) 3.08, 2.73 WO 99/10379 PCT/GB98/02542 -283 H3 O - water - N (Q ) 2.96, 2.73 Thr6P Y32L LI

N

5 3 L L2 O - water - 081 (N 53 L) 2.94, 3.25 Arg7P 1 9 N31H y32H H I NE- O (N 3 1H) 3.51 NE2 - N82 (N 3 1 H) 3.34 N12 - 081 (N 3 1 H) 3.98'

G

96 H H3 O - water - N (G 96 H ) 2.70, 2.73 Pro8P 4 Y32H Hi O r O (y 3 MH) 2.43 Ala9P 2 ps6L L2 2 y32H HI N - O I

(Y

32 H) 3.91 2 V95H H3 ProlOP 2 pS6L L2 4 F27H,Y 32 H H1 N - Oni (Y 32 ") 3.36 2 yI02H H3 Total 5 88 LI, L2, L3, H1, H3 WO 99/10379 PCT/GB98/02542 -284 Table 9 MSA buried upon SM3 - MUC1 peptide antigen complex formation. MSA has been calculated for individual SM3 CDRs and the peptide antigen alone. Residues involved in non-Proline cis-peptide bond are underlined. Residues buried MSA 1 buried (A 2 ) % total buried MSA A. SM3 light chain Ll: Ser30L 2.3 0.4 Tyr32L 48.5 9.5 Li: 26-32 (10 residues) 50.8 9.9 L2: Asn53L 4.1 0.8 Ala55L 3.0 0.6 Pro56L 33.8 6.6 L2: 50-56 (7 residues) 40.9 8.0 L3: Trp91L 44.7 8.7 Ser93L 21.1 4.1 Trp96L 16.8 3.3 L3: 89-96 (7 residues) 82.6 16.1 Total light chain 174.3 34.0 B. SM3 Heavy chain Phe27H 20.7 4.0 Thr28H 3.9 0.8 Hi: Asn31H 34.4 6.7 Tyr32H 65.6 12.8 Trp33H 58.4 11.4 Asn35H 2.9 0.6 Hi: 31-35 (5 residues) 161.3 31.5 H2: Arg52H 9.6 1.9 Leu52aH 10.7 2.1 H2: 52-65 (17 residues) 20.3 4.0 H3: VaI95H 40.8 8.0 GIy96H 19.8 3.8 Gln97H 43.4 8.5 WO 99/10379 PCT/GB98/02542 -285 Ala1O1H 5.3 1.0 Tyrl02H 23.0 4.5 H3: 95-102 (6 rsidues) 132.3 25.8 Total heavy chain 338.5 66.0 Total SM3 Fab 512.8 C. MUC1 peptide Ala2P 38.0 8.8 Ala3P 32.2 7.4 Pro4P 69.7 16.1 Asp5P 82.5 19.0 Thr6P 23.5 5.4 Arg7P 65.2 15.1 Pro8P 20.7 4.8 AIa9P 36.7 8.5 Prol0P 64.7 14.9 Total MUC1 peptide 433.2 'MSA calculated according to MS program (Connolly, 1983) using a probe radius of 1.7 A.

WO 99/1 0379 PCT1GB98/02542 -286 m "D '0 c)0 '0) 'D 0 NC-4 co ~ 00 00 00 04 m' '0 C -C -qN'0 ' 04

.

4 O to0 N 4 a\ \D r-O NO m 0 C ) a m4 m0 m~1 \'C 0 CO - '0 w 4 . -4 '4 . 00 COz CO 1m m0 m0 m4 C O C a'"A C 1 00 .0~ 0 . C- 00 co , N G

~

0 4 CO CO C) 5. 0 4 CO N94 -~ 0 o( 0 M ) cN a' r-44 N m CO CO '0 CD 4 b to NV4 N coO D a\ \.o 4 . ~ E * co~- CO -4 04 r-4 CO CN r-4 Nl 0 o ~ ~ ~ C O 4~40 '1 'N N N - it "CV C4 aO m N \D m' 0 at U >O m ~ m cu ca 0 '0D \ 0 '0 N- O 0 N \-0 0 0o '0 ' 0 ' (0N '0 ' 0O - Cu 0~ 0 ( "' 0 -0 r-4C 9 C ( R- u'c U '-4 Q C4 u0-4. ____ _ _ _ _ _ _ _ _ _ _ _ _ Cu(

Claims (33)

1. Use of the structure factors obtainable by subjecting a crystal comprising at least an epitope 5 binding fragment of the SM3 antibody, bound to a peptide recognised by the epitope binding site of SM3 to X-ray diffraction measurements to identify, screen, characterise, design or modify a chemical entity.

2. Use of the structural coordinates obtainable 10 by subjecting a crystal comprising at least the epitope binding fragment of the SM3 antibody, bound to a peptide recognised by the epitope binding site of SM3 to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements, to 15 identify, screen, characterise, design or modify a chemical entity .

3. Use according to claim 1 or claim 2 in which the fragment of the SM3 antibody is the Fab fragment obtainable by digesting SM3 with papain. 20

4. Use according to claim 1 or claim 2 in which a moiety substantially similar to a fragment of the SM3 antibody is used instead of the fragment of the SM3 antibody.

5. Use according to any one of the preceding 25 claims in which the peptide comprises the sequence Pro Asp-Thr-Arg-Pro.

6. Use according to claim 5 in which the sequence is Thr-Ser-Ala-Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly Ser-Thr. 30

7. Use of the structure factors as shown in Table 1 to identify, screen, characterise, design or modify a chemical entity.

8. Use of the structural coordinates as shown in Table 2a or 2b to identify, screen, characterise, design 35 or modify a chemical entity. WO99/10379 PCT/GB98/02542 -288

9. Use according to any one of the preceding claims of the structure factors or structural coordinates to identify, screen, characterise or design a mimic of SM3. 5

10. Use according to claim 9 in which the mimic of SM3 has a desired association with aberrantly glycosylated MUC1.

11. Use according to claim 10 in which the desired association is binding affinity with aberrantly 10 glycosylated MUC1 which is higher than the binding affinity of SM3 for aberrantly glycosylated MUC1.

12. Use according to any one of claims 9 to 11 in which the mimic of SM3 is obtainable by modification of either whole SM3 or a fragment of SM3. 15

13. Use according to claim 12 in which the modification is the replacement of Proline 56 of SM3.

14. Use according to any one of the preceding claims of the structure factors or structural coordinates to identify, screen, characterise or design a mimic of 20 the peptide epitope of MUC1 recognised by SM3.

15. Use according to claim 14 in which the mimic of the peptide is used to produce a moiety which has a desired association with aberrantly glycosylated MUC1.

16. Use according to claim 15 in which the moiety 25 is an antibody.

17. Use according to claim 16 in which the antibody is produced in a method comprising vaccinating an animal or human with the mimic of the peptide.

18. Use according to claim 14 in which the mimic 30 of the peptide can prevent or decrease an immune response.

19. Use according to any one of claims 14 to 18 in which the mimic of the peptide is obtainable by a chemical modification of a peptide. 35

20. Use accordingly to any one of claims 14 to 19 WO99/10379 PCT/GB98/02542 -289 in which the mimic of the peptide is a glycosylated peptide.

21. A chemical entity which is a mimic of the peptide epitope of MUCI recognised by SM3 and not 5 described in any database at the date of filing of the application.

22. A mimic of SM3 not described in any database at the date of filing of the application.

23. An antibody having a conformation comprising 10 an engineered non-proline cis peptide bond.

24. A crystal comprising at least an epitope binding fragment of the SM3 antibody bound to a peptide recognised by the epitope binding site of SM3.

25. A method of producing a crystal of claim 24 15 which comprises contacting the fragment of SM3 or the peptide with cadmium.

26. A machine readable data storage medium comprising a data storage material encoded with machine readable data which when read by an appropriate machine 20 is capable of displaying a three dimensional representation of a crystal as defined in claim 24.

27. A chemical entity, a mimic of SM3, a mimic of the peptide epitope of MUCl recognised by SM3, a moiety having a desired association with aberrantly glycosylated 25 MUC1 or an engineered antibody as defined in any one of claims 7 to 23 for use in a method for treatment of the human or animal body by surgery or therapy or of diagnosis practised on the human or animal body.

28. Use of a chemical entity, a mimic of SM3, a 30 mimic of the peptide epitope of MUC1 recognised by SM3, a moiety having a desired association with aberrantly glycosylated MUC1 or an engineered antibody as defined in any one of claims 7 to 23 in the production of a medicament for use in a method for anti-cancer treatment 35 of the human or animal body by surgery or therapy or of WO99/10379 PCT/GB98/02542 -290 cancer diagnosis practised on the human or animal body.

29. A method of cancer diagnosis or anti-cancer therapy comprising administering to a human or non-human animal in need thereof an effective non-toxic amount of a 5 chemical entity, a mimic of SM3, a mimic of the peptide epitope of MUC1 recognised by SM3, a moiety having a desired association with aberrantly glycosylated MUC1 or an engineered antibody as defined in any one of claims 7 to 23. 10

30. A product comprising a mimic of SM3 or a specific binding agent and an anti-tumour agent as a combined preparation for simultaneous, separate or sequential use in anti-cancer therapy.

31. A mimic of the MUC1 epitope recognised by SM3 15 for use in a method of treating a disease caused by an immune response.

32. A method of therapy of a disease caused by an immune response comprising administering to a human or non-human animal in need thereof an effective non-toxic 20 amount of a mimic of the MUC1 epitope recognised by SM3.

33. Use of the structure factors and/or structural coordinates as defined in any one of claims 1 to 8 to solve the structural coordinates of a crystal.