CA2566461C - Pyrrole compounds as inhibitors of erk protein kinase, synthesis thereof and intermediates thereto - Google Patents
Pyrrole compounds as inhibitors of erk protein kinase, synthesis thereof and intermediates thereto Download PDFInfo
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- CA2566461C CA2566461C CA2566461A CA2566461A CA2566461C CA 2566461 C CA2566461 C CA 2566461C CA 2566461 A CA2566461 A CA 2566461A CA 2566461 A CA2566461 A CA 2566461A CA 2566461 C CA2566461 C CA 2566461C
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- Prior art keywords
- compound
- pharmaceutically acceptable
- aliphatic
- acceptable salt
- optionally substituted
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Landscapes
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| LT3305776T (lt) * | 2004-05-14 | 2020-01-10 | Vertex Pharmaceuticals Incorporated | Pirolo junginiai kaip erk baltymo kinazės inhibitoriai, ir farmacinės kompozicijos su šiais junginiais |
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| CN102146074B (zh) * | 2011-01-26 | 2013-02-06 | 江苏先声药物研究有限公司 | 吡咯衍生物的制备方法及应用 |
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| EP3058371B1 (en) | 2013-10-14 | 2021-06-16 | Indiana University Research and Technology Corporation | Use of acamprosate to modulate erk 1-2 activation in animal models for fxs and asd and individuals diagnosed with fxs and asd |
| US20160264536A1 (en) | 2013-10-23 | 2016-09-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2015095835A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Methods of modulating radioiodine uptake for the treatment of radioiodine-refractory cancers |
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| WO2015095807A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of egfr and erk inhibitors |
| CA3240745A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatment using combinations of erk and raf inhibitors |
| JP6727127B2 (ja) * | 2013-12-20 | 2020-07-29 | バイオメッド バレー ディスカバリーズ，インコーポレイティド | Ｐｉ３ｋ／ａｋｔシグナル経路阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがん処置 |
| JP6678583B2 (ja) * | 2013-12-20 | 2020-04-22 | バイオメッド バレー ディスカバリーズ，インコーポレイティド | ２型ｍｅｋ阻害剤およびｅｒｋ阻害剤の組み合わせを用いるがん処置 |
| WO2015095833A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Treatment of hematologic cancers |
| WO2015095831A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of mtor and erk inhibitors |
| AU2014368927B2 (en) * | 2013-12-20 | 2018-10-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of CDK and ERK inhibitors |
| US20160310477A1 (en) * | 2013-12-20 | 2016-10-27 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of mek type 1 and erk inhibitors |
| JP7180977B2 (ja) * | 2015-01-30 | 2022-11-30 | バイオメッド バレー ディスカバリーズ，インコーポレイティド | 結晶性Ｃ２１Ｈ２２Ｃｌ２Ｎ４Ｏ２マロン酸塩 |
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| WO2016187028A1 (en) * | 2015-05-15 | 2016-11-24 | Celgene Avilomics Research, Inc. | Heteroaryl compounds, synthesis thereof, and intermediates thereto |
| CN107849046B (zh) * | 2015-06-03 | 2020-06-12 | 常州捷凯医药科技有限公司 | 作为erk抑制剂的杂环化合物 |
| WO2016192064A1 (en) | 2015-06-03 | 2016-12-08 | Js Innopharm (Shanghai) Ltd. | Heterocyclic compounds for treating psoriasis |
| EP3365334B1 (en) | 2015-10-21 | 2024-07-17 | Otsuka Pharmaceutical Co., Ltd. | Benzolactam compounds as protein kinase inhibitors |
| EP3170822A1 (en) | 2015-11-18 | 2017-05-24 | AGV Discovery | Azaindole derivatives and their use as erk kinase inhibitors |
| US10934304B2 (en) | 2016-10-05 | 2021-03-02 | Recurium Ip Holdings, Llc | Spirocyclic compounds |
| GB201706327D0 (en) | 2017-04-20 | 2017-06-07 | Otsuka Pharma Co Ltd | A pharmaceutical compound |
| JP7332589B2 (ja) * | 2017-10-12 | 2023-08-23 | ノバルティス アーゲー | 癌を治療するためのｍｄｍ２阻害剤とｅｒｋの阻害剤との組合せ |
| WO2019180141A1 (en) | 2018-03-23 | 2019-09-26 | Bayer Aktiengesellschaft | Combinations of rogaratinib |
| WO2020223177A1 (en) * | 2019-04-29 | 2020-11-05 | The Board Of Trustees Of The University Of Illinois | Mek inhibitors for corneal scarring and neovascularization |
| WO2021020841A1 (en) * | 2019-07-29 | 2021-02-04 | Standigm Inc. | Composition for preventing or treating metabolic liver disease |
| EP4212531A1 (en) | 2022-01-14 | 2023-07-19 | AGV Discovery | Azaindole derivatives and their use as erk kinase inhibitors |
| CN118765276A (zh) * | 2022-03-08 | 2024-10-11 | 甘李药业股份有限公司 | 氘代化合物，及其制备方法和应用 |
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| US5472966A (en) * | 1995-03-29 | 1995-12-05 | Bristol-Myers Squibb Company | Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| WO2000069847A1 (en) * | 1999-05-14 | 2000-11-23 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted 3-pyridyl-4-arylpyrroles, and related therapeutic and prophylactic methods |
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| AU2003237121A1 (en) * | 2002-04-26 | 2003-11-10 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
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| LT3305776T (lt) * | 2004-05-14 | 2020-01-10 | Vertex Pharmaceuticals Incorporated | Pirolo junginiai kaip erk baltymo kinazės inhibitoriai, ir farmacinės kompozicijos su šiais junginiais |
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2005
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- 2005-05-13 EP EP21190432.1A patent/EP3943489A1/en active Pending
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- 2005-05-13 WO PCT/US2005/016902 patent/WO2005113541A1/en not_active Ceased
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2006
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2013
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2016
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2019
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2020
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2023
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