CA2562756C - Methods for controlling angiogenesis and cell proliferation using a desulphatohirudin - Google Patents

Methods for controlling angiogenesis and cell proliferation using a desulphatohirudin Download PDF

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Publication number
CA2562756C
CA2562756C CA2562756A CA2562756A CA2562756C CA 2562756 C CA2562756 C CA 2562756C CA 2562756 A CA2562756 A CA 2562756A CA 2562756 A CA2562756 A CA 2562756A CA 2562756 C CA2562756 C CA 2562756C
Authority
CA
Canada
Prior art keywords
desulphatohirudin
administration
angiogenesis
glu
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2562756A
Other languages
English (en)
French (fr)
Other versions
CA2562756A1 (en
Inventor
Cheng-Der Tony Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CANYON PHARMACEUTICALS GROUP AG
Original Assignee
CANYON PHARMACEUTICALS GROUP AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by CANYON PHARMACEUTICALS GROUP AG filed Critical CANYON PHARMACEUTICALS GROUP AG
Publication of CA2562756A1 publication Critical patent/CA2562756A1/en
Application granted granted Critical
Publication of CA2562756C publication Critical patent/CA2562756C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2562756A 2004-04-12 2005-04-05 Methods for controlling angiogenesis and cell proliferation using a desulphatohirudin Expired - Lifetime CA2562756C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56174104P 2004-04-12 2004-04-12
US60/561,741 2004-04-12
PCT/US2005/011549 WO2005099749A2 (en) 2004-04-12 2005-04-05 Methods for controlling angiogenesis and cell proliferation

Publications (2)

Publication Number Publication Date
CA2562756A1 CA2562756A1 (en) 2005-10-27
CA2562756C true CA2562756C (en) 2011-08-23

Family

ID=35150501

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2562756A Expired - Lifetime CA2562756C (en) 2004-04-12 2005-04-05 Methods for controlling angiogenesis and cell proliferation using a desulphatohirudin

Country Status (13)

Country Link
US (3) US7795205B2 (cg-RX-API-DMAC7.html)
EP (1) EP1753291A4 (cg-RX-API-DMAC7.html)
JP (1) JP2007532646A (cg-RX-API-DMAC7.html)
AU (1) AU2005232625B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0509876A (cg-RX-API-DMAC7.html)
CA (1) CA2562756C (cg-RX-API-DMAC7.html)
IL (1) IL178578A (cg-RX-API-DMAC7.html)
MY (1) MY146091A (cg-RX-API-DMAC7.html)
NZ (1) NZ551146A (cg-RX-API-DMAC7.html)
SG (1) SG160323A1 (cg-RX-API-DMAC7.html)
TW (1) TWI362941B (cg-RX-API-DMAC7.html)
WO (1) WO2005099749A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200609219B (cg-RX-API-DMAC7.html)

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US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
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US20100239651A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Nitrilopropionamide delivery systems
US20100239627A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Quarternary ammonium salts delivery systems
US20100239626A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Propanediol delivery systems
US20100239630A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Phosphonium salts delivery systems
US20100239650A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Isothiazolin biodelivery systems
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
US20230159629A1 (en) * 2011-01-13 2023-05-25 Case Western Reserve University Compositions and method of modulating growth factor function
CN104906037A (zh) * 2015-06-23 2015-09-16 广西复鑫益生物科技有限公司平南分公司 一种重组水蛭素滴眼液及其制备方法
CN110404060A (zh) * 2018-04-28 2019-11-05 复旦大学 凝血酶抑制剂在制备抗肿瘤侵袭转移药物中的用途

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DE4041185A1 (de) * 1990-12-21 1992-06-25 Knoll Ag Verwendung von hirudin und dessen muteinen zur kombinationsbehandlung von tumoren
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CZ333492A3 (en) 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
AU663169B2 (en) 1992-03-04 1995-09-28 Gyogyszerkutato Intezet Kft New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
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Also Published As

Publication number Publication date
WO2005099749A2 (en) 2005-10-27
NZ551146A (en) 2009-04-30
ZA200609219B (en) 2012-02-29
IL178578A0 (en) 2007-02-11
JP2007532646A (ja) 2007-11-15
IL178578A (en) 2013-06-27
SG160323A1 (en) 2010-04-29
BRPI0509876A (pt) 2007-10-16
MY146091A (en) 2012-06-29
AU2005232625A1 (en) 2005-10-27
WO2005099749A3 (en) 2006-08-03
US20110224150A1 (en) 2011-09-15
TW200538466A (en) 2005-12-01
TWI362941B (en) 2012-05-01
US20090269422A1 (en) 2009-10-29
US20050233966A1 (en) 2005-10-20
US7795205B2 (en) 2010-09-14
CA2562756A1 (en) 2005-10-27
AU2005232625B2 (en) 2011-07-28
EP1753291A4 (en) 2009-08-12
EP1753291A2 (en) 2007-02-21

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